ARHGAP17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.97010033
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.79141728
3regulation of interferon-beta biosynthetic process (GO:0045357)4.77171591
4positive regulation by symbiont of host defense response (GO:0052509)4.62035155
5modulation by symbiont of host defense response (GO:0052031)4.62035155
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.62035155
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.62035155
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.62035155
9modulation by symbiont of host immune response (GO:0052553)4.62035155
10immunoglobulin mediated immune response (GO:0016064)4.50411834
11positive regulation of B cell differentiation (GO:0045579)4.32592189
12regulation of B cell receptor signaling pathway (GO:0050855)4.22313148
13neutrophil activation involved in immune response (GO:0002283)4.16045972
14B cell receptor signaling pathway (GO:0050853)4.07295240
15positive regulation of interferon-alpha production (GO:0032727)4.02485738
16macrophage activation involved in immune response (GO:0002281)3.83212172
17antigen processing and presentation of endogenous antigen (GO:0019883)3.82378925
18regulation of interferon-alpha production (GO:0032647)3.82282575
19regulation of B cell differentiation (GO:0045577)3.78633604
20CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.77871255
21cellular response to zinc ion (GO:0071294)3.61168753
22neutrophil activation (GO:0042119)3.54127333
23NIK/NF-kappaB signaling (GO:0038061)3.53136613
24response to muramyl dipeptide (GO:0032495)3.50410317
25regulation of interleukin-12 biosynthetic process (GO:0045075)3.50227449
26regulation of gamma-delta T cell activation (GO:0046643)3.49614400
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.49006343
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.49006343
29regulation of gamma-delta T cell differentiation (GO:0045586)3.42689176
30germinal center formation (GO:0002467)3.40742713
31B cell mediated immunity (GO:0019724)3.36610570
32response to peptidoglycan (GO:0032494)3.36152405
33granulocyte activation (GO:0036230)3.36076213
34negative regulation of granulocyte differentiation (GO:0030853)3.35119836
35detection of bacterium (GO:0016045)3.24943871
36negative thymic T cell selection (GO:0045060)3.22283716
37defense response to protozoan (GO:0042832)3.19019473
38thymic T cell selection (GO:0045061)3.17757891
39positive regulation of interferon-beta production (GO:0032728)3.14969449
40mature B cell differentiation (GO:0002335)3.14634859
41detection of other organism (GO:0098543)3.12134924
42response to type I interferon (GO:0034340)3.11948563
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.10931992
44cellular response to type I interferon (GO:0071357)3.07155323
45type I interferon signaling pathway (GO:0060337)3.07155323
46respiratory burst (GO:0045730)3.05127045
47interferon-gamma-mediated signaling pathway (GO:0060333)3.03242202
48positive regulation of antigen processing and presentation (GO:0002579)3.01764886
49negative T cell selection (GO:0043383)3.00853663
50negative regulation of B cell proliferation (GO:0030889)2.99583139
51positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.98262301
52negative regulation of phagocytosis (GO:0050765)2.97605346
53myeloid cell activation involved in immune response (GO:0002275)2.97300296
54positive thymic T cell selection (GO:0045059)2.97257069
55pinocytosis (GO:0006907)2.97151020
56response to host immune response (GO:0052572)2.95858951
57response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.95858951
58positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.93550621
59mannose metabolic process (GO:0006013)2.91940628
60B cell homeostasis (GO:0001782)2.91055644
61T cell lineage commitment (GO:0002360)2.90987434
62natural killer cell mediated immunity (GO:0002228)2.90790114
63natural killer cell mediated cytotoxicity (GO:0042267)2.90790114
64positive regulation of humoral immune response (GO:0002922)2.90150716
65I-kappaB phosphorylation (GO:0007252)2.89433011
66T cell selection (GO:0045058)2.86778119
67myeloid dendritic cell activation (GO:0001773)2.86492257
68response to protozoan (GO:0001562)2.84409681
69positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.84275741
70negative regulation of interleukin-12 production (GO:0032695)2.82993034
71regulation of type I interferon-mediated signaling pathway (GO:0060338)2.81723413
72negative regulation of erythrocyte differentiation (GO:0045647)2.80770627
73response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.80631563
74response to host (GO:0075136)2.80631563
75response to host defenses (GO:0052200)2.80631563
76T cell costimulation (GO:0031295)2.80391313
77regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78689930
78neutrophil mediated immunity (GO:0002446)2.78149862
79lymphocyte costimulation (GO:0031294)2.77802633
80leukocyte aggregation (GO:0070486)2.76228431
81detection of external biotic stimulus (GO:0098581)2.71829011
82B cell proliferation (GO:0042100)2.71432451
83regulation of mast cell degranulation (GO:0043304)2.71277308
84positive T cell selection (GO:0043368)2.71139732
85lipopolysaccharide-mediated signaling pathway (GO:0031663)2.68997699
86regulation of interferon-gamma biosynthetic process (GO:0045072)2.67820655
87negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.65821910
88negative regulation of cell killing (GO:0031342)2.65821910
89mature B cell differentiation involved in immune response (GO:0002313)2.65631133
90regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.65375718
91regulation of histone H3-K27 methylation (GO:0061085)2.63298511
92positive regulation of isotype switching (GO:0045830)2.62744445
93myeloid dendritic cell differentiation (GO:0043011)2.62249436
94regulation of antigen processing and presentation (GO:0002577)2.61117512
95regulation of B cell apoptotic process (GO:0002902)2.61024646
96histone H3-K36 demethylation (GO:0070544)2.60805942
97regulation of alpha-beta T cell proliferation (GO:0046640)2.58249648
98regulation of mast cell activation involved in immune response (GO:0033006)2.56158357
99regulation of B cell proliferation (GO:0030888)2.55997574
100positive regulation of B cell proliferation (GO:0030890)2.55242113
101T cell migration (GO:0072678)2.55042956
102tolerance induction (GO:0002507)2.54991418
103macrophage activation (GO:0042116)2.54972979
104positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.54196058
105cellular response to interferon-beta (GO:0035458)2.53275299
106positive regulation of B cell activation (GO:0050871)2.52853081
107regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.52697694
108regulation of interferon-beta production (GO:0032648)2.52433585
109regulation of mast cell activation (GO:0033003)2.51728897
110regulation of T-helper 1 cell differentiation (GO:0045625)2.51229543
111cellular extravasation (GO:0045123)2.50851737
112antigen receptor-mediated signaling pathway (GO:0050851)2.50600182
113lymphocyte homeostasis (GO:0002260)2.49798995
114cellular response to virus (GO:0098586)2.49180022
115leukocyte cell-cell adhesion (GO:0007159)2.48592371
116regulation of dendritic cell antigen processing and presentation (GO:0002604)2.48565784
117microglial cell activation (GO:0001774)2.48148589
118adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.46830322
119myeloid leukocyte activation (GO:0002274)2.46689213
120detection of molecule of bacterial origin (GO:0032490)2.46271979
121positive regulation of myotube differentiation (GO:0010831)2.45925391
122Arp2/3 complex-mediated actin nucleation (GO:0034314)2.42585643
123positive regulation of B cell mediated immunity (GO:0002714)2.42141942
124positive regulation of immunoglobulin mediated immune response (GO:0002891)2.42141942
125regulation of interleukin-12 production (GO:0032655)2.41814148
126positive regulation of interleukin-12 production (GO:0032735)2.40440278
127dendritic cell differentiation (GO:0097028)2.40130702
1283-UTR-mediated mRNA stabilization (GO:0070935)2.39496784
129regulation of integrin activation (GO:0033623)2.39149509
130response to interleukin-15 (GO:0070672)2.37620218
131T-helper 1 type immune response (GO:0042088)2.37202621
132positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.36981905
133positive regulation of type 2 immune response (GO:0002830)2.36551628
134cellular response to interferon-gamma (GO:0071346)2.35865673
135detection of biotic stimulus (GO:0009595)2.34529573
136regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.34303308
137activation of JUN kinase activity (GO:0007257)2.33327062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.57907359
2E2F7_22180533_ChIP-Seq_HELA_Human4.93612000
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.60420706
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.79483554
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.71254258
6* IRF8_27001747_Chip-Seq_BMDM_Mouse3.37311696
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.35856516
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.29345773
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.23692875
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.22507682
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.10186845
12MYC_22102868_ChIP-Seq_BL_Human2.90537966
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.89256728
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.87124604
15VDR_21846776_ChIP-Seq_THP-1_Human2.86757918
16SCL_19346495_ChIP-Seq_HPC-7_Human2.82319731
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.74865582
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.67390433
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.67293086
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.41000810
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.34181083
22SPI1_23547873_ChIP-Seq_NB4_Human2.28507415
23VDR_24763502_ChIP-Seq_THP-1_Human2.26339409
24* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.16113892
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.14860256
26MAF_26560356_Chip-Seq_TH1_Human2.13401815
27MYB_26560356_Chip-Seq_TH2_Human2.09767572
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.05238198
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.04011345
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02947671
31MYB_26560356_Chip-Seq_TH1_Human2.01251372
32* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.99603736
33* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.99442944
34SPI1_23127762_ChIP-Seq_K562_Human1.98506470
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.94204894
36TCF7_22412390_ChIP-Seq_EML_Mouse1.92469100
37RUNX_20019798_ChIP-Seq_JUKART_Human1.90769658
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88849607
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.87271683
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79425285
41UTX_26944678_Chip-Seq_JUKART_Human1.78753414
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54532352
43PU_27001747_Chip-Seq_BMDM_Mouse1.53622428
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.52575583
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52015567
46PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49722687
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45926371
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45184762
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44069517
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43751180
51GATA1_22025678_ChIP-Seq_K562_Human1.43517150
52* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41663687
53KDM2B_26808549_Chip-Seq_DND41_Human1.40524315
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39331658
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36540799
56* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34757948
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33794465
58MAF_26560356_Chip-Seq_TH2_Human1.30745147
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.30234889
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29922243
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27815560
62* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25963366
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22152010
64CIITA_25753668_ChIP-Seq_RAJI_Human1.21753859
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.20634299
66GATA3_27048872_Chip-Seq_THYMUS_Human1.19136814
67TFEB_21752829_ChIP-Seq_HELA_Human1.17522601
68RACK7_27058665_Chip-Seq_MCF-7_Human1.17380232
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17285365
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16492745
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14582013
72VDR_24787735_ChIP-Seq_THP-1_Human1.14441251
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14305428
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.09537908
75FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07795681
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07586536
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06271410
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.05591967
79* GATA1_19941827_ChIP-Seq_MEL_Mouse1.05146204
80TP53_22127205_ChIP-Seq_IMR90_Human1.04410156
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02697821
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00481007
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.00165154
84CLOCK_20551151_ChIP-Seq_293T_Human0.96648415
85KDM2B_26808549_Chip-Seq_K562_Human0.96387600
86STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95445382
87* BCOR_27268052_Chip-Seq_Bcells_Human0.95292108
88NCOR1_26117541_ChIP-Seq_K562_Human0.95259911
89BCL6_27268052_Chip-Seq_Bcells_Human0.93985577
90* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93663605
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92363997
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.91914115
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91751005
94* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91572279
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91130156
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90547472
97CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89638803
98E2F1_21310950_ChIP-Seq_MCF-7_Human0.87762688
99CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87507322
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87329665
101PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86867233
102CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86470335
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86294668
104TP63_17297297_ChIP-ChIP_HaCaT_Human0.86128731
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85644341
106SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85388518
107PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85056338
108LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84903520
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84082111
110PPARA_22158963_ChIP-Seq_LIVER_Mouse0.83831789
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83695149
112GATA3_26560356_Chip-Seq_TH2_Human0.83562788
113* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82673919
114PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79317632
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71377323
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70902409
117GATA2_19941826_ChIP-Seq_K562_Human0.70293826
118GATA1_19941826_ChIP-Seq_K562_Human0.69794172
119LXR_22292898_ChIP-Seq_THP-1_Human0.69081552
120RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.68550115
121RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.67637360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.27811458
2MP0000685_abnormal_immune_system3.08463530
3MP0001800_abnormal_humoral_immune2.99490239
4MP0003303_peritoneal_inflammation2.95503487
5MP0001790_abnormal_immune_system2.95309167
6MP0005387_immune_system_phenotype2.95309167
7MP0000569_abnormal_digit_pigmentation2.79971434
8MP0003436_decreased_susceptibility_to2.75665820
9MP0002452_abnormal_antigen_presenting2.73618582
10MP0005000_abnormal_immune_tolerance2.59808487
11MP0002396_abnormal_hematopoietic_system2.51755312
12MP0005671_abnormal_response_to2.50215321
13MP0002419_abnormal_innate_immunity2.46326373
14MP0002723_abnormal_immune_serum2.43917693
15MP0005025_abnormal_response_to2.35488416
16MP0002420_abnormal_adaptive_immunity2.33343726
17MP0001819_abnormal_immune_cell2.32965548
18MP0009278_abnormal_bone_marrow2.29787110
19MP0009785_altered_susceptibility_to2.23916179
20MP0002148_abnormal_hypersensitivity_rea2.18352748
21MP0002398_abnormal_bone_marrow2.12360190
22MP0003705_abnormal_hypodermis_morpholog2.09630937
23MP0008438_abnormal_cutaneous_collagen2.04156106
24MP0002166_altered_tumor_susceptibility2.03758771
25MP0005174_abnormal_tail_pigmentation2.01129600
26MP0005464_abnormal_platelet_physiology1.97820686
27MP0000716_abnormal_immune_system1.93956132
28MP0005058_abnormal_lysosome_morphology1.93780665
29MP0002405_respiratory_system_inflammati1.90148071
30MP0000689_abnormal_spleen_morphology1.87805378
31MP0008057_abnormal_DNA_replication1.87034677
32MP0006082_CNS_inflammation1.83568512
33MP0002138_abnormal_hepatobiliary_system1.82544029
34MP0003300_gastrointestinal_ulcer1.82067864
35MP0003172_abnormal_lysosome_physiology1.80607180
36MP0005397_hematopoietic_system_phenotyp1.79255219
37MP0001545_abnormal_hematopoietic_system1.79255219
38MP0001853_heart_inflammation1.76322413
39MP0004510_myositis1.75166588
40MP0003183_abnormal_peptide_metabolism1.74803137
41MP0004808_abnormal_hematopoietic_stem1.73177216
42MP0005451_abnormal_body_composition1.72154494
43MP0003279_aneurysm1.69127254
44MP0002722_abnormal_immune_system1.68123200
45MP0002429_abnormal_blood_cell1.66482011
46MP0010155_abnormal_intestine_physiology1.66027374
47MP0001873_stomach_inflammation1.64161756
48MP0002006_tumorigenesis1.62870714
49MP0003763_abnormal_thymus_physiology1.61394031
50MP0010352_gastrointestinal_tract_polyps1.61356137
51MP0004947_skin_inflammation1.59505745
52MP0000465_gastrointestinal_hemorrhage1.55467996
53MP0001845_abnormal_inflammatory_respons1.53472717
54MP0001348_abnormal_lacrimal_gland1.46111654
55MP0009333_abnormal_splenocyte_physiolog1.45358824
56MP0010307_abnormal_tumor_latency1.42356566
57MP0003724_increased_susceptibility_to1.42159332
58MP0003191_abnormal_cellular_cholesterol1.41691349
59MP0000490_abnormal_crypts_of1.39172932
60MP0003950_abnormal_plasma_membrane1.35507182
61MP0001533_abnormal_skeleton_physiology1.33914822
62MP0005076_abnormal_cell_differentiation1.33672821
63MP0000703_abnormal_thymus_morphology1.33577194
64MP0002877_abnormal_melanocyte_morpholog1.31460188
65MP0003448_altered_tumor_morphology1.28235291
66MP0003828_pulmonary_edema1.28108659
67MP0003566_abnormal_cell_adhesion1.26489519
68MP0000858_altered_metastatic_potential1.25425908
69MP0005623_abnormal_meninges_morphology1.22855868
70MP0000015_abnormal_ear_pigmentation1.21748589
71MP0005310_abnormal_salivary_gland1.17383058
72MP0008469_abnormal_protein_level1.15402982
73MP0002933_joint_inflammation1.10513341
74MP0003866_abnormal_defecation1.06592470
75MP0003077_abnormal_cell_cycle1.04648017
76MP0010368_abnormal_lymphatic_system1.03727426
77MP0000343_altered_response_to1.03208152
78MP0008260_abnormal_autophagy1.00061827
79MP0005075_abnormal_melanosome_morpholog0.99691322
80MP0005257_abnormal_intraocular_pressure0.99532774
81MP0002998_abnormal_bone_remodeling0.99199181
82MP0000003_abnormal_adipose_tissue0.98974358
83MP0005360_urolithiasis0.96904911
84MP0002019_abnormal_tumor_incidence0.96402185
85MP0003111_abnormal_nucleus_morphology0.95635872
86MP0003091_abnormal_cell_migration0.93725164
87MP0000371_diluted_coat_color0.92808951
88MP0010094_abnormal_chromosome_stability0.92571580
89MP0009115_abnormal_fat_cell0.91327673
90MP0003693_abnormal_embryo_hatching0.90834513
91MP0004185_abnormal_adipocyte_glucose0.87148050
92MP0000767_abnormal_smooth_muscle0.86934480
93MP0009384_cardiac_valve_regurgitation0.85638288
94MP0008058_abnormal_DNA_repair0.84782886
95MP0005023_abnormal_wound_healing0.84754193
96MP0001663_abnormal_digestive_system0.83911322
97MP0003045_fibrosis0.81419041
98MP0001915_intracranial_hemorrhage0.80814804
99MP0005375_adipose_tissue_phenotype0.79752901
100MP0009764_decreased_sensitivity_to0.79642536
101MP0003453_abnormal_keratinocyte_physiol0.79351278
102MP0000249_abnormal_blood_vessel0.78963709
103MP0002254_reproductive_system_inflammat0.78824275
104MP0004858_abnormal_nervous_system0.77433640
105MP0008007_abnormal_cellular_replicative0.77323814
106MP0002009_preneoplasia0.76940526
107MP0005670_abnormal_white_adipose0.76800823
108MP0001851_eye_inflammation0.76461031
109MP0002928_abnormal_bile_duct0.73988143
110MP0006054_spinal_hemorrhage0.73227222
111MP0005390_skeleton_phenotype0.73164663
112MP0005164_abnormal_response_to0.71468049
113MP0009840_abnormal_foam_cell0.70973155
114MP0000313_abnormal_cell_death0.70120923
115MP0005621_abnormal_cell_physiology0.69843145
116MP0002095_abnormal_skin_pigmentation0.69750426
117MP0001879_abnormal_lymphatic_vessel0.65171109
118MP0005666_abnormal_adipose_tissue0.64069826
119MP0009763_increased_sensitivity_to0.63661236
120MP0004883_abnormal_blood_vessel0.63407159
121MP0005166_decreased_susceptibility_to0.62481397
122MP0005503_abnormal_tendon_morphology0.62365557
123MP0000350_abnormal_cell_proliferation0.61981600
124MP0004272_abnormal_basement_membrane0.60859257
125MP0002136_abnormal_kidney_physiology0.60302822
126MP0003795_abnormal_bone_structure0.56102018
127MP0004264_abnormal_extraembryonic_tissu0.55529113
128MP0001958_emphysema0.54536358

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.35888115
2Recurrent bacterial skin infections (HP:0005406)4.88738449
3Eczematoid dermatitis (HP:0000976)4.30751713
4Recurrent viral infections (HP:0004429)4.10608640
5Cellulitis (HP:0100658)3.84114882
6Recurrent fungal infections (HP:0002841)3.82217032
7Agammaglobulinemia (HP:0004432)3.68818400
8Elevated erythrocyte sedimentation rate (HP:0003565)3.63539868
9Mediastinal lymphadenopathy (HP:0100721)3.58836527
10Colitis (HP:0002583)3.55684646
11Autoimmune thrombocytopenia (HP:0001973)3.46346685
12Abnormality of the fingertips (HP:0001211)3.40887907
13IgM deficiency (HP:0002850)3.39493269
14Myositis (HP:0100614)3.32113782
15Protrusio acetabuli (HP:0003179)3.28347915
16Meningitis (HP:0001287)3.25340686
17Recurrent skin infections (HP:0001581)3.25320038
18Inflammation of the large intestine (HP:0002037)3.22307206
19Vasculitis (HP:0002633)3.16381076
20Gastrointestinal inflammation (HP:0004386)3.11020667
21Abnormality of macrophages (HP:0004311)3.03339581
22Gastrointestinal stroma tumor (HP:0100723)2.99375612
23Recurrent cutaneous fungal infections (HP:0011370)2.96132306
24Chronic mucocutaneous candidiasis (HP:0002728)2.96132306
25Osteomyelitis (HP:0002754)2.88733367
26Periodontitis (HP:0000704)2.84024229
27Recurrent gram-negative bacterial infections (HP:0005420)2.83912237
28Gingivitis (HP:0000230)2.80537570
29Recurrent bronchitis (HP:0002837)2.80136761
30Recurrent pneumonia (HP:0006532)2.70760600
31Obstructive lung disease (HP:0006536)2.70656533
32Chronic obstructive pulmonary disease (HP:0006510)2.70656533
33Orchitis (HP:0100796)2.70224494
34Panhypogammaglobulinemia (HP:0003139)2.70084788
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.66971635
36Aortic aneurysm (HP:0004942)2.66369779
37Hematochezia (HP:0002573)2.65631412
38Chronic otitis media (HP:0000389)2.65492634
39Abnormality of the peritoneum (HP:0002585)2.62876534
40Recurrent lower respiratory tract infections (HP:0002783)2.54590552
41Optic neuritis (HP:0100653)2.53462858
42Retrobulbar optic neuritis (HP:0100654)2.53462858
43Lymphopenia (HP:0001888)2.51767740
44Thyroiditis (HP:0100646)2.51356315
45Spontaneous hematomas (HP:0007420)2.51150951
46Pustule (HP:0200039)2.51056440
47Abnormality of cells of the lymphoid lineage (HP:0012140)2.42206347
48Peritonitis (HP:0002586)2.40455559
49Emphysema (HP:0002097)2.40405323
50Vacuolated lymphocytes (HP:0001922)2.38212445
51Fatigue (HP:0012378)2.37314974
52Interstitial pulmonary disease (HP:0006530)2.36754347
53Prolonged bleeding time (HP:0003010)2.36390367
54Abnormality of liposaccharide metabolism (HP:0010968)2.35111172
55Abnormality of glycosphingolipid metabolism (HP:0004343)2.35111172
56Abnormality of glycolipid metabolism (HP:0010969)2.35111172
57Gastrointestinal infarctions (HP:0005244)2.33056565
58B lymphocytopenia (HP:0010976)2.28788419
59Abnormality of B cell number (HP:0010975)2.28788419
60Eosinophilia (HP:0001880)2.27157460
61Leukocytosis (HP:0001974)2.27069233
62Increased IgE level (HP:0003212)2.26978531
63Increased cerebral lipofuscin (HP:0011813)2.24665757
64Premature rupture of membranes (HP:0001788)2.23695679
65IgA deficiency (HP:0002720)2.23364965
66Leukopenia (HP:0001882)2.21706017
67Systemic lupus erythematosus (HP:0002725)2.21290355
68Pulmonary infiltrates (HP:0002113)2.21029143
69Restrictive lung disease (HP:0002091)2.20915143
70Thrombocytosis (HP:0001894)2.19223813
71Spinal cord lesions (HP:0100561)2.19191809
72Syringomyelia (HP:0003396)2.19191809
73Stomatitis (HP:0010280)2.18857194
74Petechiae (HP:0000967)2.18159440
75Abnormality of T cell physiology (HP:0011840)2.16527127
76Verrucae (HP:0200043)2.14446375
77Papilloma (HP:0012740)2.14446375
78Agnosia (HP:0010524)2.11347580
79Granulocytopenia (HP:0001913)2.09474763
80Sepsis (HP:0100806)2.09106364
81Recurrent sinusitis (HP:0011108)2.07460944
82Basal ganglia calcification (HP:0002135)2.07000581
83Aortic dissection (HP:0002647)2.06134579
84Absent frontal sinuses (HP:0002688)2.05796512
85Viral hepatitis (HP:0006562)2.04492794
86Chest pain (HP:0100749)2.04439022
87Abnormality of T cells (HP:0002843)2.02811835
88Increased neuronal autofluorescent lipopigment (HP:0002074)2.02458797
89Lymphoma (HP:0002665)2.00998638
90Cheilitis (HP:0100825)1.99324610
91Disproportionate tall stature (HP:0001519)1.98588830
92Thoracic kyphosis (HP:0002942)1.97937018
93Dilatation of the ascending aorta (HP:0005111)1.97170759
94Arterial thrombosis (HP:0004420)1.96572255
95Skin ulcer (HP:0200042)1.96526560
96Dysostosis multiplex (HP:0000943)1.94543387
97Gingival bleeding (HP:0000225)1.94489204
98Cerebral aneurysm (HP:0004944)1.93474408
99Urticaria (HP:0001025)1.92742624
100Hypertensive crisis (HP:0100735)1.92387037
101Hemoptysis (HP:0002105)1.92248579
102Hypoplasia of the thymus (HP:0000778)1.90032028
103Spondylolisthesis (HP:0003302)1.89288767
104Chromsome breakage (HP:0040012)1.89096652
105Myocardial infarction (HP:0001658)1.88314831
106Aneurysm (HP:0002617)1.88122383
107Abnormality of the thoracic spine (HP:0100711)1.87824149
108Persistence of primary teeth (HP:0006335)1.87630785
109Encephalitis (HP:0002383)1.87489268
110Urethral obstruction (HP:0000796)1.86759663
111Acrocyanosis (HP:0001063)1.86415190
112Flat acetabular roof (HP:0003180)1.86032590
113Thoracolumbar scoliosis (HP:0002944)1.86020399
114Abnormality of T cell number (HP:0011839)1.85857158
115Abnormality of eosinophils (HP:0001879)1.85136491
116Long eyelashes (HP:0000527)1.84867496
117Disinhibition (HP:0000734)1.84705867
118Chronic diarrhea (HP:0002028)1.84207608
119Axonal loss (HP:0003447)1.82868978
120Prostate neoplasm (HP:0100787)1.82113553
121Epistaxis (HP:0000421)1.81765335
122Hemorrhage of the eye (HP:0011885)1.81215189
123T lymphocytopenia (HP:0005403)1.81206175
124Mitral valve prolapse (HP:0001634)1.80064717
125Premature loss of primary teeth (HP:0006323)1.79410659
126Nonimmune hydrops fetalis (HP:0001790)1.79260643
127Flexion contracture of toe (HP:0005830)1.78892508
128Joint contractures involving the joints of the feet (HP:0100492)1.78892508
129Long palpebral fissure (HP:0000637)1.78590149
130Vertebral compression fractures (HP:0002953)1.78282818
131IgG deficiency (HP:0004315)1.78017179
132Conjunctival telangiectasia (HP:0000524)1.77531630
133Asymmetric septal hypertrophy (HP:0001670)1.76020024
134Abnormality of the pleura (HP:0002103)1.74832217
135Malnutrition (HP:0004395)1.73391768
136Blue sclerae (HP:0000592)1.73130784
137Skin rash (HP:0000988)1.73045508

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.26728250
2CDK122.88808774
3PRPF4B2.77169282
4TYK22.70036269
5ERN12.61861732
6BLK2.59542322
7RIPK42.57675565
8MAP3K142.54598791
9KIT2.53664021
10IRAK42.49784380
11MAP3K102.42098077
12SMG12.37996933
13CSF1R2.37251396
14TRIB32.28898303
15IRAK32.25916244
16TBK12.21556858
17TGFBR22.08174839
18JAK32.00729955
19IKBKE1.97900418
20IKBKB1.93470736
21TAOK31.83957923
22STK101.83423363
23BTK1.74999713
24CDC42BPA1.60951872
25JAK11.55802966
26SYK1.51851401
27ZAP701.51127061
28EEF2K1.51004516
29MAP3K131.49473441
30GRK61.48346451
31TEC1.41309082
32RPS6KA41.40157950
33CSK1.37377949
34HCK1.36584782
35TXK1.34573689
36CHUK1.33494349
37PIM11.33076336
38MATK1.31501423
39MAP2K31.29348382
40BRD41.28245932
41SIK11.27628721
42CAMK1D1.20160934
43SIK21.17793281
44LYN1.14861226
45PIM21.10923944
46CLK11.10187586
47LCK1.09696327
48TAOK21.08274877
49MAP3K71.04785001
50MARK31.04679921
51TRPM71.02344986
52CDK40.99953928
53PDGFRA0.96832661
54CAMK1G0.96554329
55CDK60.90833786
56FGFR30.90811831
57EPHB10.88030970
58FLT30.87533468
59STK40.87305212
60NEK20.87216290
61DDR20.86578198
62SIK30.84918872
63LRRK20.84255069
64ITK0.84068255
65FES0.80177062
66TESK20.78853696
67PDK10.78453213
68MAP3K110.76868806
69PTK60.75625173
70PDPK10.74898921
71MAP2K20.70254135
72MARK20.70209201
73KSR20.69479312
74ATR0.67525890
75YES10.67355431
76PIK3CG0.63813879
77CDK70.63053822
78TNK20.60682532
79MAP3K10.60590072
80MAP3K80.59160389
81CDK90.57885433
82JAK20.57787264
83NEK90.57696484
84ABL10.56697711
85MAPK120.55769881
86FGFR40.54851717
87MAPKAPK20.54231243
88STK30.52388335
89HIPK20.51925891
90MAPK70.51652722
91MAPKAPK30.51380105
92KDR0.48478874
93BMX0.48036266
94MAP3K30.48011183
95RPS6KA20.47568106
96PAK40.47351670
97ICK0.47213796
98MST40.47122909
99RPS6KA60.46592772
100RIPK10.46573077
101MOS0.46114344
102EGFR0.45137268
103FGR0.44861570
104TTN0.44096377
105PAK20.43960772
106MAP3K50.41442252
107PRKCQ0.41127084
108MTOR0.40513187
109BMPR20.39097984
110NLK0.38921280
111RPS6KL10.38112872
112RPS6KC10.38112872
113DYRK1B0.37592738
114MAPK110.37589842
115RPS6KB20.36689403
116PRKD20.34586387
117DYRK30.34259347
118TGFBR10.34236899
119NUAK10.33854795
120PKN20.33264892
121MAPK150.31640433
122PRKCD0.29411894
123GRK10.28528856
124SCYL20.27881020
125MAPK30.27859358
126MELK0.25228043

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.92018925
2Autoimmune thyroid disease_Homo sapiens_hsa053202.89376302
3Leishmaniasis_Homo sapiens_hsa051402.57594476
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.55896171
5Primary immunodeficiency_Homo sapiens_hsa053402.48862947
6Osteoclast differentiation_Homo sapiens_hsa043802.29432075
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.08289717
8Type I diabetes mellitus_Homo sapiens_hsa049401.99756180
9Measles_Homo sapiens_hsa051621.97452147
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.93470638
11Hematopoietic cell lineage_Homo sapiens_hsa046401.87733211
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.84995877
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.79466714
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76945219
15Herpes simplex infection_Homo sapiens_hsa051681.75975602
16Influenza A_Homo sapiens_hsa051641.70206551
17Antigen processing and presentation_Homo sapiens_hsa046121.67445423
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.67182261
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66362807
20Tuberculosis_Homo sapiens_hsa051521.62269616
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.60721307
22Pertussis_Homo sapiens_hsa051331.57256135
23Toxoplasmosis_Homo sapiens_hsa051451.57064379
24Other glycan degradation_Homo sapiens_hsa005111.52752562
25Malaria_Homo sapiens_hsa051441.49164650
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48875160
27Apoptosis_Homo sapiens_hsa042101.45718430
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45176342
29Legionellosis_Homo sapiens_hsa051341.45135247
30Staphylococcus aureus infection_Homo sapiens_hsa051501.43954684
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.37143605
32TNF signaling pathway_Homo sapiens_hsa046681.37058912
33Base excision repair_Homo sapiens_hsa034101.35906874
34Hepatitis B_Homo sapiens_hsa051611.34438345
35DNA replication_Homo sapiens_hsa030301.33211256
36Chronic myeloid leukemia_Homo sapiens_hsa052201.31786610
37Acute myeloid leukemia_Homo sapiens_hsa052211.31160816
38Shigellosis_Homo sapiens_hsa051311.29305209
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25007231
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23099954
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21655542
42T cell receptor signaling pathway_Homo sapiens_hsa046601.20722260
43Chemokine signaling pathway_Homo sapiens_hsa040621.19971757
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.16108570
45Allograft rejection_Homo sapiens_hsa053301.15420940
46Non-homologous end-joining_Homo sapiens_hsa034501.14865858
47Lysosome_Homo sapiens_hsa041421.14146550
48Small cell lung cancer_Homo sapiens_hsa052221.06610990
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06314825
50Pancreatic cancer_Homo sapiens_hsa052121.05386613
51Hepatitis C_Homo sapiens_hsa051601.02608875
52Salmonella infection_Homo sapiens_hsa051321.02573618
53Graft-versus-host disease_Homo sapiens_hsa053321.02381237
54Epstein-Barr virus infection_Homo sapiens_hsa051690.99602921
55Viral myocarditis_Homo sapiens_hsa054160.98547026
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97194478
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97025969
58Platelet activation_Homo sapiens_hsa046110.92331843
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89475114
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.89425482
61Asthma_Homo sapiens_hsa053100.89115470
62Notch signaling pathway_Homo sapiens_hsa043300.88420377
63Mismatch repair_Homo sapiens_hsa034300.86897747
64Bladder cancer_Homo sapiens_hsa052190.86624192
65Viral carcinogenesis_Homo sapiens_hsa052030.84215708
66Homologous recombination_Homo sapiens_hsa034400.83627738
67HTLV-I infection_Homo sapiens_hsa051660.83101888
68MicroRNAs in cancer_Homo sapiens_hsa052060.82364659
69p53 signaling pathway_Homo sapiens_hsa041150.78446781
70African trypanosomiasis_Homo sapiens_hsa051430.78359691
71Fanconi anemia pathway_Homo sapiens_hsa034600.72857470
72Renal cell carcinoma_Homo sapiens_hsa052110.69650473
73Rheumatoid arthritis_Homo sapiens_hsa053230.67548567
74Prolactin signaling pathway_Homo sapiens_hsa049170.66590565
75Non-small cell lung cancer_Homo sapiens_hsa052230.63073828
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61503261
77Lysine degradation_Homo sapiens_hsa003100.60791646
78Phagosome_Homo sapiens_hsa041450.60029793
79Cell cycle_Homo sapiens_hsa041100.59666953
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59578133
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59250014
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.58765623
83Colorectal cancer_Homo sapiens_hsa052100.58612874
84Endometrial cancer_Homo sapiens_hsa052130.58017660
85Proteoglycans in cancer_Homo sapiens_hsa052050.54982426
86FoxO signaling pathway_Homo sapiens_hsa040680.54236505
87Thyroid cancer_Homo sapiens_hsa052160.53581007
88Choline metabolism in cancer_Homo sapiens_hsa052310.51740433
89Adherens junction_Homo sapiens_hsa045200.51656745
90Renin-angiotensin system_Homo sapiens_hsa046140.51423793
91Prostate cancer_Homo sapiens_hsa052150.51387924
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50556797
93HIF-1 signaling pathway_Homo sapiens_hsa040660.49926782
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49583553
95Spliceosome_Homo sapiens_hsa030400.49278780
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49190598
97Caffeine metabolism_Homo sapiens_hsa002320.48951974
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.48594212
99VEGF signaling pathway_Homo sapiens_hsa043700.47970781
100GnRH signaling pathway_Homo sapiens_hsa049120.47768384
101Insulin resistance_Homo sapiens_hsa049310.47753276
102mTOR signaling pathway_Homo sapiens_hsa041500.46330734
103Amoebiasis_Homo sapiens_hsa051460.46181374
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44505592
105Pathways in cancer_Homo sapiens_hsa052000.44155310
106Systemic lupus erythematosus_Homo sapiens_hsa053220.42799458
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39570604
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38356667
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38281644
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.38208376
111Vitamin digestion and absorption_Homo sapiens_hsa049770.38149398
112Endocytosis_Homo sapiens_hsa041440.38123365
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.37836719
114Nucleotide excision repair_Homo sapiens_hsa034200.37717517
115MAPK signaling pathway_Homo sapiens_hsa040100.37401014
116Focal adhesion_Homo sapiens_hsa045100.36892166
117Inositol phosphate metabolism_Homo sapiens_hsa005620.36781850
118Dorso-ventral axis formation_Homo sapiens_hsa043200.35516947
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35160238

Most similar genes based on co-expression Upload to Enrichr

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