ARHGAP18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al., 2009 [PubMed 19065146]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)5.26219321
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.14315413
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.77693936
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.77693936
5low-density lipoprotein particle remodeling (GO:0034374)4.60206393
6antigen processing and presentation of endogenous antigen (GO:0019883)4.59099619
7cilium or flagellum-dependent cell motility (GO:0001539)4.57367665
8regulation of metalloenzyme activity (GO:0048552)4.29645445
9regulation of integrin-mediated signaling pathway (GO:2001044)4.23110471
10hypotonic response (GO:0006971)4.10448240
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.91196993
12positive regulation of gamma-delta T cell activation (GO:0046645)3.80909221
13blood coagulation, intrinsic pathway (GO:0007597)3.71815961
14pinocytosis (GO:0006907)3.67639308
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.67069469
16positive regulation by organism of defense response of other organism involved in symbiotic interact3.67069469
17modulation by symbiont of host immune response (GO:0052553)3.67069469
18positive regulation by symbiont of host defense response (GO:0052509)3.67069469
19modulation by symbiont of host defense response (GO:0052031)3.67069469
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.67069469
21very-low-density lipoprotein particle assembly (GO:0034379)3.65816948
22positive regulation of blood coagulation (GO:0030194)3.53385919
23positive regulation of hemostasis (GO:1900048)3.53385919
24regulation of interferon-beta biosynthetic process (GO:0045357)3.53327168
25motile cilium assembly (GO:0044458)3.52662843
26regulation of macrophage chemotaxis (GO:0010758)3.52041333
27definitive hemopoiesis (GO:0060216)3.50609251
28regulation of platelet activation (GO:0010543)3.44301666
29negative regulation of platelet activation (GO:0010544)3.41266936
30platelet degranulation (GO:0002576)3.40039510
31cilium movement (GO:0003341)3.39301069
32angiogenesis involved in wound healing (GO:0060055)3.36297340
33regulation of apoptotic cell clearance (GO:2000425)3.35961547
34positive regulation of endothelial cell differentiation (GO:0045603)3.35407966
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.30936256
36cellular extravasation (GO:0045123)3.30630024
37positive regulation of coagulation (GO:0050820)3.28983772
38positive regulation of B cell differentiation (GO:0045579)3.25224360
39high-density lipoprotein particle remodeling (GO:0034375)3.24410147
40endothelium development (GO:0003158)3.23325698
41lipoxygenase pathway (GO:0019372)3.19890825
42negative regulation of granulocyte differentiation (GO:0030853)3.19037283
43regulation of cholesterol esterification (GO:0010872)3.18846564
44plasma lipoprotein particle assembly (GO:0034377)3.17679279
45fibrinolysis (GO:0042730)3.16899068
46antigen processing and presentation via MHC class Ib (GO:0002475)3.16358864
47glycosphingolipid catabolic process (GO:0046479)3.12460114
48negative regulation of protein localization to plasma membrane (GO:1903077)3.10918695
49regulation of gamma-delta T cell differentiation (GO:0045586)3.10165583
50oligosaccharide catabolic process (GO:0009313)3.10121451
51pyrimidine-containing compound transmembrane transport (GO:0072531)3.09686075
52negative regulation of protein localization to cell surface (GO:2000009)3.09569231
53positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.07549015
54negative regulation of humoral immune response (GO:0002921)3.06295982
55regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.05372145
56regulation of B cell receptor signaling pathway (GO:0050855)3.05358719
57negative regulation of norepinephrine secretion (GO:0010700)3.03910355
58barbed-end actin filament capping (GO:0051016)3.03697177
59reverse cholesterol transport (GO:0043691)3.03235520
60regulation of gamma-delta T cell activation (GO:0046643)3.01389568
61membrane raft organization (GO:0031579)2.99985120
62negative regulation of homotypic cell-cell adhesion (GO:0034111)2.99939821
63glycolipid catabolic process (GO:0019377)2.99491102
64platelet aggregation (GO:0070527)2.99033722
65protein-lipid complex assembly (GO:0065005)2.97986470
66negative regulation of blood coagulation (GO:0030195)2.97254809
67negative regulation of hemostasis (GO:1900047)2.97254809
68negative regulation of coagulation (GO:0050819)2.97197978
69regulation of cholesterol storage (GO:0010885)2.95384266
70plasma lipoprotein particle remodeling (GO:0034369)2.94571068
71protein-lipid complex remodeling (GO:0034368)2.94571068
72macromolecular complex remodeling (GO:0034367)2.94571068
73positive regulation of extracellular matrix organization (GO:1903055)2.92911834
74regulation of platelet aggregation (GO:0090330)2.92882364
75vascular endothelial growth factor signaling pathway (GO:0038084)2.92449894
76immunoglobulin mediated immune response (GO:0016064)2.91048846
77response to xenobiotic stimulus (GO:0009410)2.90751571
78positive regulation of interferon-alpha production (GO:0032727)2.90666299
79neutrophil activation involved in immune response (GO:0002283)2.87382704
80regulation of blood coagulation (GO:0030193)2.86760631
81regulation of hemostasis (GO:1900046)2.86760631
82Arp2/3 complex-mediated actin nucleation (GO:0034314)2.85105857
83phagocytosis, recognition (GO:0006910)2.85022734
84positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.84664543
85plasma lipoprotein particle organization (GO:0071827)2.84060614
86positive regulation of mast cell activation (GO:0033005)2.83798702
87iron ion import (GO:0097286)2.82624567
88cholesterol efflux (GO:0033344)2.82482065
89negative regulation of phagocytosis (GO:0050765)2.81754309
90negative regulation of nitric oxide biosynthetic process (GO:0045019)2.81640827
91lymph vessel development (GO:0001945)2.81345447
92regulation of coagulation (GO:0050818)2.81261826
93positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.80861085
94valine metabolic process (GO:0006573)2.80527150
95regulation of interferon-alpha production (GO:0032647)2.80209731
96B cell mediated immunity (GO:0019724)2.77874272
97macrophage activation involved in immune response (GO:0002281)2.77336259
98regulation of mononuclear cell migration (GO:0071675)2.76209646
99regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.75388700
100protein-lipid complex subunit organization (GO:0071825)2.75356577
101positive regulation of antigen processing and presentation (GO:0002579)2.75289523
102cholesterol transport (GO:0030301)2.74998405
103sterol transport (GO:0015918)2.74998405
104positive regulation of leukocyte degranulation (GO:0043302)2.74310836
105plasma lipoprotein particle clearance (GO:0034381)2.72989579
106ribosomal small subunit assembly (GO:0000028)2.71771194
107peptidyl-glutamic acid carboxylation (GO:0017187)2.70265527
108protein carboxylation (GO:0018214)2.70265527
109positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.70014229
110hepatocyte apoptotic process (GO:0097284)2.69700110
111regulation of complement activation (GO:0030449)2.67693518
112negative regulation of lipid storage (GO:0010888)2.66859619
113positive regulation of wound healing (GO:0090303)2.65911730
114positive regulation of receptor recycling (GO:0001921)2.64619510
115low-density lipoprotein particle clearance (GO:0034383)2.64539834
116mesodermal cell differentiation (GO:0048333)2.63187180
117cyclooxygenase pathway (GO:0019371)2.61511073
118negative regulation of protein activation cascade (GO:2000258)2.60687134
119negative regulation of complement activation (GO:0045916)2.60341446
120surfactant homeostasis (GO:0043129)2.59716931
121phagocytosis, engulfment (GO:0006911)2.59579125
122positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.59171772
123epithelial cilium movement (GO:0003351)2.58994398
124extracellular fibril organization (GO:0043206)2.58785068
125response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.57710940
126response to host immune response (GO:0052572)2.57710940
127regulation of protein activation cascade (GO:2000257)2.55771666
128response to interferon-alpha (GO:0035455)2.54720209
129fusion of sperm to egg plasma membrane (GO:0007342)2.54534723
130leukocyte migration involved in inflammatory response (GO:0002523)2.53937290
131negative regulation of wound healing (GO:0061045)2.52788084
132toxin transport (GO:1901998)2.52575610
133ceramide catabolic process (GO:0046514)2.52060391
134membrane invagination (GO:0010324)2.51925870
135negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.51061603
136transcytosis (GO:0045056)2.49533488
137macrophage activation (GO:0042116)2.49073353
138positive regulation of cellular amide metabolic process (GO:0034250)2.48540312
139regulation of integrin activation (GO:0033623)2.47851230
140blood vessel maturation (GO:0001955)2.46813690
141positive regulation of interferon-beta production (GO:0032728)2.46011375
142endothelial tube morphogenesis (GO:0061154)2.45624916
143morphogenesis of an endothelium (GO:0003159)2.45624916
144response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.45340336
145response to host (GO:0075136)2.45340336
146response to host defenses (GO:0052200)2.45340336
147regulation of B cell differentiation (GO:0045577)2.45168031
148response to muramyl dipeptide (GO:0032495)2.43863268
149negative regulation of macrophage differentiation (GO:0045650)2.41851938
150negative regulation of erythrocyte differentiation (GO:0045647)2.40011826
151ovulation from ovarian follicle (GO:0001542)2.39841657
152response to interferon-beta (GO:0035456)2.39157242
153megakaryocyte development (GO:0035855)2.38969102
154regulation of macrophage differentiation (GO:0045649)2.37300767
155cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.37031796
156thrombin receptor signaling pathway (GO:0070493)2.35663761
157regulation of interleukin-12 biosynthetic process (GO:0045075)2.35328447
158positive regulation of vasculogenesis (GO:2001214)2.34215496
159positive regulation of macrophage differentiation (GO:0045651)2.33990824
160platelet dense granule organization (GO:0060155)2.33445043
161cellular response to thyroid hormone stimulus (GO:0097067)2.29255391
162production of molecular mediator involved in inflammatory response (GO:0002532)2.28213133
163mature B cell differentiation involved in immune response (GO:0002313)2.27825750
164execution phase of apoptosis (GO:0097194)2.27731612
165myeloid dendritic cell activation (GO:0001773)2.27488018
166positive regulation of lamellipodium assembly (GO:0010592)2.26542733
167growth hormone receptor signaling pathway (GO:0060396)2.23941362
168detection of molecule of bacterial origin (GO:0032490)2.23741673
169response to hydroperoxide (GO:0033194)2.23688564
170cell adhesion mediated by integrin (GO:0033627)2.22467785
171dendritic cell migration (GO:0036336)2.22200007
172negative regulation of stress fiber assembly (GO:0051497)2.20677559
173germ cell migration (GO:0008354)2.20323029
174microglial cell activation (GO:0001774)2.20067992
175positive regulation of natural killer cell differentiation (GO:0032825)2.19935537
176leukocyte tethering or rolling (GO:0050901)2.19540676
177regulation of macrophage derived foam cell differentiation (GO:0010743)2.16405785
178positive regulation of lamellipodium organization (GO:1902745)2.15618905
179actin nucleation (GO:0045010)2.13616166
180dendritic cell chemotaxis (GO:0002407)2.13353448
181response to type I interferon (GO:0034340)2.13144719
182response to thyroid hormone (GO:0097066)2.13052438
183response to peptidoglycan (GO:0032494)2.12149829
184peptide catabolic process (GO:0043171)2.11618697
185regulation of antigen processing and presentation (GO:0002577)2.10804524
186apoptotic cell clearance (GO:0043277)2.10390449

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.02183310
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.80980201
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.12017790
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.10777524
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.04760784
6GATA1_22025678_ChIP-Seq_K562_Human3.01776182
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.01316143
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.97265141
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93348551
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.85649234
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.85637091
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.70615678
13SCL_19346495_ChIP-Seq_HPC-7_Human2.70600412
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.65945351
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53452257
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.40676175
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.19137896
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.18266537
19GATA2_21666600_ChIP-Seq_HMVEC_Human2.15903735
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.13022851
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12816859
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.09301559
23CLOCK_20551151_ChIP-Seq_293T_Human2.06512287
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.06293925
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.06221257
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.02217130
27E2F7_22180533_ChIP-Seq_HELA_Human2.01683905
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.97876304
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.97819677
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.96236870
31* SPI1_23547873_ChIP-Seq_NB4_Human1.95984613
32SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.95741517
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.95172922
34* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93054469
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.89729719
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88651740
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.76764651
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76208818
39RUNX_20019798_ChIP-Seq_JUKART_Human1.74017067
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73012999
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71822823
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71484584
43MYB_26560356_Chip-Seq_TH2_Human1.70735230
44* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.69696599
45* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.69696599
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69148319
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67931471
48MAF_26560356_Chip-Seq_TH1_Human1.67824064
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.67232766
50TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66604075
51* FOXA2_19822575_ChIP-Seq_HepG2_Human1.66301476
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.61001759
53VDR_21846776_ChIP-Seq_THP-1_Human1.59774369
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.59428936
55* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.57028377
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55448137
57VDR_24763502_ChIP-Seq_THP-1_Human1.54933614
58MYB_26560356_Chip-Seq_TH1_Human1.53642369
59SPI1_23127762_ChIP-Seq_K562_Human1.53405037
60* CJUN_26792858_Chip-Seq_BT549_Human1.51368675
61TP53_16413492_ChIP-PET_HCT116_Human1.50664578
62PPARA_22158963_ChIP-Seq_LIVER_Mouse1.49760453
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48293939
64* PU_27001747_Chip-Seq_BMDM_Mouse1.47730427
65RXR_22158963_ChIP-Seq_LIVER_Mouse1.45820565
66* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.43399096
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43083470
68TCF7_22412390_ChIP-Seq_EML_Mouse1.43068628
69MYC_22102868_ChIP-Seq_BL_Human1.41683113
70* BRD4_25478319_ChIP-Seq_HGPS_Human1.41254324
71FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40923483
72* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40611842
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.38926410
74* TP63_23658742_ChIP-Seq_EP156T_Human1.38698350
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37012755
76JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32971301
77* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32779139
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31830334
79* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30877687
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30646842
81* LXR_22158963_ChIP-Seq_LIVER_Mouse1.30355529
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29988905
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27962700
84* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27388467
85TCF4_18268006_ChIP-ChIP_LS174T_Human1.25483479
86* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22685339
87JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21917741
88* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21818907
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20816705
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20305124
91TRIM28_21343339_ChIP-Seq_HEK293_Human1.19908952
92UTX_26944678_Chip-Seq_JUKART_Human1.19560405
93* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19189004
94CDX2_22108803_ChIP-Seq_LS180_Human1.18793701
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18750338
96* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18143150
97GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17509320
98CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17500393
99EP300_21415370_ChIP-Seq_HL-1_Mouse1.17133238
100AR_21909140_ChIP-Seq_LNCAP_Human1.16093432
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15726108
102* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14618252
103PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13456112
104* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13364692
105ESR1_20079471_ChIP-ChIP_T-47D_Human1.12642644
106FOXO3_23340844_ChIP-Seq_DLD1_Human1.12330991
107PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.11820852
108* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11310044
109SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11247115
110SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11247115
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11030927
112* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10562184
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08529987
114CDX2_20551321_ChIP-Seq_CACO-2_Human1.07366230
115SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06751832
116TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05366223
117GATA4_25053715_ChIP-Seq_YYC3_Human1.05163386
118* HNF4A_19822575_ChIP-Seq_HepG2_Human1.04633067
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04477367
120FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03722990
121* SOX2_20726797_ChIP-Seq_SW620_Human1.03475971
122AHR_22903824_ChIP-Seq_MCF-7_Human1.02940141
123FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02900707
124CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01166689
125* VDR_24787735_ChIP-Seq_THP-1_Human1.00587713
126GATA2_19941826_ChIP-Seq_K562_Human0.99984815
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99858329
128ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98356648
129GATA3_27048872_Chip-Seq_THYMUS_Human0.97696727
130GATA6_25053715_ChIP-Seq_YYC3_Human0.97384327
131* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97352671
132CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96198502
133FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95752912
134* NCOR1_26117541_ChIP-Seq_K562_Human0.94792284
135GATA1_19941827_ChIP-Seq_MEL_Mouse0.93384390
136GATA1_19941826_ChIP-Seq_K562_Human0.93158148

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane3.37435189
2MP0001835_abnormal_antigen_presentation2.89769458
3MP0010368_abnormal_lymphatic_system2.54684857
4MP0002396_abnormal_hematopoietic_system2.38349116
5MP0008875_abnormal_xenobiotic_pharmacok2.37717044
6MP0005365_abnormal_bile_salt2.35381393
7MP0003300_gastrointestinal_ulcer2.23678689
8MP0003724_increased_susceptibility_to2.21035546
9MP0002139_abnormal_hepatobiliary_system2.19265353
10MP0003191_abnormal_cellular_cholesterol2.13283560
11MP0002132_abnormal_respiratory_system2.08846189
12MP0009780_abnormal_chondrocyte_physiolo2.07557432
13MP0001879_abnormal_lymphatic_vessel2.07532989
14MP0003828_pulmonary_edema1.99912544
15MP0003436_decreased_susceptibility_to1.97927361
16MP0009278_abnormal_bone_marrow1.94629844
17MP0005360_urolithiasis1.88727068
18MP0006054_spinal_hemorrhage1.88039502
19MP0009785_altered_susceptibility_to1.87765287
20MP0002419_abnormal_innate_immunity1.86583222
21MP0003656_abnormal_erythrocyte_physiolo1.86272308
22MP0001853_heart_inflammation1.85110524
23MP0004808_abnormal_hematopoietic_stem1.82875420
24MP0005671_abnormal_response_to1.78282076
25MP0005058_abnormal_lysosome_morphology1.76654950
26MP0005397_hematopoietic_system_phenotyp1.74159654
27MP0001545_abnormal_hematopoietic_system1.74159654
28MP0005167_abnormal_blood-brain_barrier1.72532838
29MP0002877_abnormal_melanocyte_morpholog1.71868377
30MP0002166_altered_tumor_susceptibility1.70926697
31MP0009840_abnormal_foam_cell1.70608683
32MP0002452_abnormal_antigen_presenting1.68458822
33MP0000343_altered_response_to1.67668664
34MP0001873_stomach_inflammation1.67538114
35MP0005464_abnormal_platelet_physiology1.65916310
36MP0005085_abnormal_gallbladder_physiolo1.65618694
37MP0000685_abnormal_immune_system1.64946992
38MP0005025_abnormal_response_to1.64680508
39MP0001800_abnormal_humoral_immune1.61748787
40MP0003705_abnormal_hypodermis_morpholog1.61259155
41MP0002148_abnormal_hypersensitivity_rea1.59625059
42MP0003718_maternal_effect1.56607359
43MP0003303_peritoneal_inflammation1.56270902
44MP0010155_abnormal_intestine_physiology1.53924332
45MP0005000_abnormal_immune_tolerance1.52566411
46MP0001819_abnormal_immune_cell1.48264326
47MP0005165_increased_susceptibility_to1.48037446
48MP0002420_abnormal_adaptive_immunity1.47949802
49MP0002723_abnormal_immune_serum1.40819479
50MP0002405_respiratory_system_inflammati1.40658734
51MP0000465_gastrointestinal_hemorrhage1.40640309
52MP0003566_abnormal_cell_adhesion1.40336027
53MP0004272_abnormal_basement_membrane1.38714457
54MP0005387_immune_system_phenotype1.36654484
55MP0001790_abnormal_immune_system1.36654484
56MP0004147_increased_porphyrin_level1.35289332
57MP0010352_gastrointestinal_tract_polyps1.34334435
58MP0003091_abnormal_cell_migration1.30186995
59MP0001845_abnormal_inflammatory_respons1.28892148
60MP0003075_altered_response_to1.28442371
61MP0001533_abnormal_skeleton_physiology1.27892830
62MP0002006_tumorigenesis1.24716104
63MP0004947_skin_inflammation1.24248720
64MP0002138_abnormal_hepatobiliary_system1.20275434
65MP0002398_abnormal_bone_marrow1.20119479
66MP0003448_altered_tumor_morphology1.19560730
67MP0003279_aneurysm1.19490297
68MP0002254_reproductive_system_inflammat1.19367239
69MP0009333_abnormal_splenocyte_physiolog1.19115980
70MP0010307_abnormal_tumor_latency1.16304681
71MP0008469_abnormal_protein_level1.15934025
72MP0000689_abnormal_spleen_morphology1.14157290
73MP0005395_other_phenotype1.12995526
74MP0003806_abnormal_nucleotide_metabolis1.12485546
75MP0000716_abnormal_immune_system1.11016076
76MP0002722_abnormal_immune_system1.08968006
77MP0005408_hypopigmentation1.08497391
78MP0003943_abnormal_hepatobiliary_system1.07775209
79MP0000249_abnormal_blood_vessel1.06895314
80MP0009764_decreased_sensitivity_to1.05955969
81MP0000490_abnormal_crypts_of1.05045298
82MP0003453_abnormal_keratinocyte_physiol1.04559630
83MP0002136_abnormal_kidney_physiology1.04249519
84MP0003172_abnormal_lysosome_physiology1.04068139
85MP0002429_abnormal_blood_cell1.03233108
86MP0006082_CNS_inflammation1.01733519
87MP0001958_emphysema1.00077470
88MP0003195_calcinosis0.98625483
89MP0010329_abnormal_lipoprotein_level0.97456175
90MP0003868_abnormal_feces_composition0.96990956
91MP0008438_abnormal_cutaneous_collagen0.95540116
92MP0000767_abnormal_smooth_muscle0.95534745
93MP0005670_abnormal_white_adipose0.95292332
94MP0000858_altered_metastatic_potential0.94468152
95MP0009643_abnormal_urine_homeostasis0.93954998
96MP0002896_abnormal_bone_mineralization0.93396255
97MP0010678_abnormal_skin_adnexa0.93246971
98MP0004084_abnormal_cardiac_muscle0.91890761
99MP0003866_abnormal_defecation0.90637317
100MP0004782_abnormal_surfactant_physiolog0.90479895
101MP0003763_abnormal_thymus_physiology0.88971213
102MP0001915_intracranial_hemorrhage0.88922123
103MP0005410_abnormal_fertilization0.88806996
104MP0005083_abnormal_biliary_tract0.88760957
105MP0005409_darkened_coat_color0.87654115
106MP0000604_amyloidosis0.87186510
107MP0002998_abnormal_bone_remodeling0.84029059
108MP0009763_increased_sensitivity_to0.83925502
109MP0005451_abnormal_body_composition0.83071209
110MP0000609_abnormal_liver_physiology0.82685936
111MP0001756_abnormal_urination0.81766654
112MP0000569_abnormal_digit_pigmentation0.81356036
113MP0002168_other_aberrant_phenotype0.80748106
114MP0001666_abnormal_nutrient_absorption0.80639548
115MP0008007_abnormal_cellular_replicative0.80460205
116MP0010234_abnormal_vibrissa_follicle0.79834766
117MP0005257_abnormal_intraocular_pressure0.79666593
118MP0001542_abnormal_bone_strength0.78823835
119MP0004883_abnormal_blood_vessel0.77971349
120MP0009697_abnormal_copulation0.77512734
121MP0001663_abnormal_digestive_system0.77361066
122MP0003183_abnormal_peptide_metabolism0.76169361
123MP0005164_abnormal_response_to0.75847696
124MP0004019_abnormal_vitamin_homeostasis0.75735205
125MP0008004_abnormal_stomach_pH0.75605061
126MP0005166_decreased_susceptibility_to0.75165914
127MP0005023_abnormal_wound_healing0.73716015
128MP0002009_preneoplasia0.73126114
129MP0003252_abnormal_bile_duct0.73102447
130MP0004130_abnormal_muscle_cell0.72984012
131MP0004510_myositis0.72895083
132MP0000598_abnormal_liver_morphology0.72694311
133MP0009115_abnormal_fat_cell0.72426765

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.04967578
2Abnormal ciliary motility (HP:0012262)4.99047649
3Absent/shortened dynein arms (HP:0200106)4.93594509
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.93594509
5Abnormal respiratory motile cilium morphology (HP:0005938)4.85855132
6Abnormal respiratory epithelium morphology (HP:0012253)4.85855132
7Abnormal respiratory motile cilium physiology (HP:0012261)4.81854198
8Rhinitis (HP:0012384)4.61141325
9Recurrent abscess formation (HP:0002722)3.72405438
10Vacuolated lymphocytes (HP:0001922)3.69247961
11Systemic lupus erythematosus (HP:0002725)3.61098470
12Spontaneous hematomas (HP:0007420)3.47808946
13Myositis (HP:0100614)3.46210217
14Hematochezia (HP:0002573)3.44968955
15Abnormality of the common coagulation pathway (HP:0010990)3.43450978
16Recurrent bacterial skin infections (HP:0005406)3.35632740
17Male infertility (HP:0003251)3.32124357
18Bronchiectasis (HP:0002110)3.19745619
19Glomerulonephritis (HP:0000099)3.14077728
20Eczematoid dermatitis (HP:0000976)3.09862611
21Acanthocytosis (HP:0001927)3.06346431
22Chronic bronchitis (HP:0004469)2.98734261
23Xanthomatosis (HP:0000991)2.97893990
24Increased cerebral lipofuscin (HP:0011813)2.93259082
25Orchitis (HP:0100796)2.91216193
26Prolonged bleeding time (HP:0003010)2.87879304
27Syringomyelia (HP:0003396)2.86392199
28Spinal cord lesions (HP:0100561)2.86392199
29Thrombocytosis (HP:0001894)2.86074825
30Deep venous thrombosis (HP:0002625)2.79409665
31Hyperlipoproteinemia (HP:0010980)2.79133224
32Conjunctival telangiectasia (HP:0000524)2.78815308
33Abnormality of glycolipid metabolism (HP:0010969)2.78010771
34Abnormality of liposaccharide metabolism (HP:0010968)2.78010771
35Abnormality of glycosphingolipid metabolism (HP:0004343)2.78010771
36IgM deficiency (HP:0002850)2.75692246
37Nephritis (HP:0000123)2.73944875
38Abnormality of macrophages (HP:0004311)2.71720253
39Increased neuronal autofluorescent lipopigment (HP:0002074)2.71345977
40Petechiae (HP:0000967)2.69613741
41Osteolytic defects of the hand bones (HP:0009699)2.67747066
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.67747066
43Mitral stenosis (HP:0001718)2.65511200
44Pustule (HP:0200039)2.61041637
45Abnormality of complement system (HP:0005339)2.60395607
46Abnormal platelet function (HP:0011869)2.60312616
47Impaired platelet aggregation (HP:0003540)2.60312616
48Interstitial pulmonary disease (HP:0006530)2.58987887
49Autoimmune thrombocytopenia (HP:0001973)2.58005601
50Abnormal platelet volume (HP:0011876)2.57974871
51Papillary thyroid carcinoma (HP:0002895)2.56802302
52Chronic otitis media (HP:0000389)2.53842146
53Recurrent viral infections (HP:0004429)2.52237392
54Complement deficiency (HP:0004431)2.50669298
55Vascular calcification (HP:0004934)2.49265836
56Colitis (HP:0002583)2.49140419
57Abnormality of the nasal mucosa (HP:0000433)2.48466690
58Cerebral aneurysm (HP:0004944)2.48265157
59Metaphyseal irregularity (HP:0003025)2.47403059
60Cardiovascular calcification (HP:0011915)2.45716199
61Prostate neoplasm (HP:0100787)2.45449224
62Elevated erythrocyte sedimentation rate (HP:0003565)2.44691187
63Recurrent fungal infections (HP:0002841)2.44584585
64Infertility (HP:0000789)2.44528572
65Increased mean platelet volume (HP:0011877)2.43771731
66Reduced subcutaneous adipose tissue (HP:0003758)2.42436612
67Recurrent sinusitis (HP:0011108)2.37394897
68Arterial thrombosis (HP:0004420)2.34699381
69Cellulitis (HP:0100658)2.33182634
70Optic neuritis (HP:0100653)2.31051840
71Retrobulbar optic neuritis (HP:0100654)2.31051840
72Disinhibition (HP:0000734)2.28158856
73Nausea (HP:0002018)2.27630948
74Myocardial infarction (HP:0001658)2.27392361
75Aortic aneurysm (HP:0004942)2.26557435
76Congenital, generalized hypertrichosis (HP:0004540)2.23155269
77Flat acetabular roof (HP:0003180)2.21400315
78Mesangial abnormality (HP:0001966)2.21250154
79Dysostosis multiplex (HP:0000943)2.20319540
80Recurrent gram-negative bacterial infections (HP:0005420)2.19832213
81Inflammation of the large intestine (HP:0002037)2.17883288
82Fat malabsorption (HP:0002630)2.16192995
83Mediastinal lymphadenopathy (HP:0100721)2.16059299
84Arterial tortuosity (HP:0005116)2.15528716
85Facial diplegia (HP:0001349)2.13679957
86Esophageal varix (HP:0002040)2.12415046
87Gastrointestinal inflammation (HP:0004386)2.11669134
88Subacute progressive viral hepatitis (HP:0006572)2.10304701
89Hemorrhage of the eye (HP:0011885)2.08655075
90Vascular tortuosity (HP:0004948)2.07708101
91Hepatosplenomegaly (HP:0001433)2.07523542
92Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.07379249
93Joint hemorrhage (HP:0005261)2.05832509
94Polycythemia (HP:0001901)2.05296291
95Acute myeloid leukemia (HP:0004808)2.05158534
96Abnormality of the prostate (HP:0008775)2.05046126
97Bruising susceptibility (HP:0000978)2.03906506
98Hypophosphatemic rickets (HP:0004912)2.01039274
99Poikilocytosis (HP:0004447)1.99786478
100Abnormality of carpal bone ossification (HP:0006257)1.99233905
101Periodontitis (HP:0000704)1.99171778
102Mucosal telangiectasiae (HP:0100579)1.98106332
103Epistaxis (HP:0000421)1.96475298
104Recurrent skin infections (HP:0001581)1.94681965
105Abnormality of the vasculature of the conjunctiva (HP:0008054)1.90214643
106Keratoconjunctivitis sicca (HP:0001097)1.89859435
107Hypoproteinemia (HP:0003075)1.89588677
108Thyroiditis (HP:0100646)1.88887825
109Hypercholesterolemia (HP:0003124)1.88639637
110Steatorrhea (HP:0002570)1.88050063
111Conjugated hyperbilirubinemia (HP:0002908)1.87963091
112Abnormality of the acetabulum (HP:0003170)1.87569688
113Mucopolysacchariduria (HP:0008155)1.85954273
114Urinary glycosaminoglycan excretion (HP:0003541)1.85954273
115Viral hepatitis (HP:0006562)1.85257830
116Tetraparesis (HP:0002273)1.84940160
117Nasal polyposis (HP:0100582)1.84014736
118Chronic sinusitis (HP:0011109)1.82957825
119Gingivitis (HP:0000230)1.81518603
120Keratoconjunctivitis (HP:0001096)1.81475203
121Thick nail (HP:0001805)1.81053787
122Purpura (HP:0000979)1.80683180
123Menorrhagia (HP:0000132)1.79698459
124Abnormality of proline metabolism (HP:0010907)1.79575263
125Hydroxyprolinuria (HP:0003080)1.79575263
126Encephalitis (HP:0002383)1.79368210
127Skin nodule (HP:0200036)1.77631595
128Panhypogammaglobulinemia (HP:0003139)1.77264206
129Hypertriglyceridemia (HP:0002155)1.76098988
130Gingival bleeding (HP:0000225)1.75895992
131Recurrent otitis media (HP:0000403)1.73794514
132Bronchitis (HP:0012387)1.73564092
133Osteomyelitis (HP:0002754)1.73016343
134Chronic obstructive pulmonary disease (HP:0006510)1.72922245
135Obstructive lung disease (HP:0006536)1.72922245
136Aortic dissection (HP:0002647)1.72724442
137Hyperglycinuria (HP:0003108)1.72692290
138Increased IgE level (HP:0003212)1.71045298
139Increased serum ferritin (HP:0003281)1.70637823
140Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70566077
141Meningitis (HP:0001287)1.70461822
142Axonal loss (HP:0003447)1.70369876
143Abnormality of glutamine family amino acid metabolism (HP:0010902)1.69575753
144Distal lower limb muscle weakness (HP:0009053)1.69360513
145Glucose intolerance (HP:0000833)1.69316228
146Abnormality of monocarboxylic acid metabolism (HP:0010996)1.69268902
147Abnormality of iron homeostasis (HP:0011031)1.69146008
148Protrusio acetabuli (HP:0003179)1.68876447
149Abnormality of polysaccharide metabolism (HP:0011012)1.68743634
150Abnormality of glycosaminoglycan metabolism (HP:0004371)1.68743634
151Abnormality of mucopolysaccharide metabolism (HP:0011020)1.68743634
152Bilateral sensorineural hearing impairment (HP:0008619)1.67924907
153Abnormality of transition element cation homeostasis (HP:0011030)1.64261395
154Premature rupture of membranes (HP:0001788)1.63243292
155Upper limb muscle weakness (HP:0003484)1.63242530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE13.43555089
2TGFBR23.40888903
3KDR3.04688046
4EIF2AK12.64070816
5TYK22.53059232
6RIPK42.35597594
7BMPR22.32492023
8MAP4K12.28619865
9MAP3K142.24983224
10KIT2.17949790
11TGFBR12.08454746
12MAP3K122.08071903
13IRAK32.07400872
14IRAK41.85043847
15EPHA21.83644893
16STK101.82226017
17TBK11.80720133
18ACVR1B1.75246912
19TEC1.70202087
20NME21.68296787
21LRRK21.67330914
22STK391.67030868
23PKN21.60676566
24MET1.59499258
25NEK91.59172958
26BTK1.57674746
27BMX1.55919261
28JAK31.54192298
29TRIB31.51972476
30PIM21.50930036
31ERN11.50491532
32EEF2K1.49835626
33JAK11.45531354
34PDK21.44330922
35MAP2K31.43043968
36MAP3K131.39367087
37FRK1.38353057
38PTK2B1.37844531
39RIPK11.37427971
40ZAP701.37202671
41PTK61.34232416
42ERBB41.34125585
43NUAK11.33806203
44TXK1.33753602
45EPHB11.29651933
46MAPK151.29126675
47IKBKE1.28605406
48BLK1.27867334
49CSF1R1.25336985
50FER1.23886364
51FLT31.23390340
52FGFR31.22635106
53TRPM71.21683793
54CHUK1.20890429
55FGFR41.20354963
56ARAF1.19592396
57MST41.17534853
58TAOK31.17030046
59SCYL21.15542875
60CDK61.15004141
61AKT31.12984326
62PIM11.11047006
63FGR1.09361551
64PBK1.07978766
65MAPKAPK31.07562187
66IKBKB1.06918922
67ITK1.06796370
68MAP3K21.06118539
69CAMKK21.05339802
70EIF2AK31.05291045
71MAP3K101.02859731
72TTN1.02808390
73MST1R1.02206260
74PAK40.98459393
75DDR20.96411928
76MYLK0.96221572
77MOS0.93210381
78RPS6KA40.89456172
79PDPK10.88340848
80MAP3K30.86885164
81STK30.86100727
82CSK0.85516106
83BRSK20.83431732
84JAK20.83077639
85PRKG20.82596421
86WNK40.79584484
87MATK0.78782590
88DYRK1B0.78062021
89PIK3CG0.77135519
90CAMK1D0.76613852
91MELK0.76401120
92EIF2AK20.75299451
93NEK20.74086710
94CDK80.74032372
95STK240.73526924
96MARK30.72263006
97NEK60.72162505
98LCK0.72074888
99SYK0.69307379
100LYN0.68679672
101PTK20.68043458
102SIK10.65072093
103PDK10.64275592
104HCK0.64248363
105CDK90.62188451
106BCR0.60277868
107PAK10.59949281
108PDGFRA0.57996717
109MAP3K50.57940714
110PRKAA20.57239657
111ABL20.56644278
112ERBB30.55531621
113INSRR0.55418513
114GRK10.55025927
115CCNB10.52942137
116MAP3K80.52897953
117MAPK110.51671358
118GRK70.51105780
119LIMK10.50980620
120ABL10.50266768
121WEE10.49891218
122IGF1R0.49604035
123TSSK60.49420093
124CDK40.49322939
125RET0.49058178
126RAF10.49002797
127STK40.48013035
128EPHB20.47386668
129PAK20.46582801
130NLK0.45555523
131FGFR10.45505313
132ROCK10.44007209
133YES10.43844495
134LMTK20.43672546
135MAPKAPK20.43025804
136EPHA30.42170227
137TTK0.42138557
138EGFR0.40429630
139LATS10.40062991
140PDGFRB0.39893162
141MAPK40.39604171
142ICK0.39391552
143ZAK0.39059454
144ILK0.39046638
145AURKB0.38354088
146DMPK0.38309800
147CDC42BPA0.37352199
148TNIK0.36567447
149ERBB20.35344794

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.70323862
2Leishmaniasis_Homo sapiens_hsa051402.18634561
3Osteoclast differentiation_Homo sapiens_hsa043801.87371303
4Glutathione metabolism_Homo sapiens_hsa004801.85058318
5Renin-angiotensin system_Homo sapiens_hsa046141.84126689
6Vitamin digestion and absorption_Homo sapiens_hsa049771.81098664
7Hematopoietic cell lineage_Homo sapiens_hsa046401.77709150
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.77585876
9Toxoplasmosis_Homo sapiens_hsa051451.75861624
10Pertussis_Homo sapiens_hsa051331.72310668
11Other glycan degradation_Homo sapiens_hsa005111.70464311
12Caffeine metabolism_Homo sapiens_hsa002321.66300456
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66291433
14Antigen processing and presentation_Homo sapiens_hsa046121.64542126
15Measles_Homo sapiens_hsa051621.61290224
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61047335
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.59376448
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.59150844
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.57996802
20Legionellosis_Homo sapiens_hsa051341.57015480
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.56792891
22Lysosome_Homo sapiens_hsa041421.54876359
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54345411
24Complement and coagulation cascades_Homo sapiens_hsa046101.48767223
25Steroid biosynthesis_Homo sapiens_hsa001001.48706501
26Small cell lung cancer_Homo sapiens_hsa052221.47598623
27Fatty acid degradation_Homo sapiens_hsa000711.44460693
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.43401199
29B cell receptor signaling pathway_Homo sapiens_hsa046621.43258821
30Sphingolipid metabolism_Homo sapiens_hsa006001.42881523
31Viral myocarditis_Homo sapiens_hsa054161.41862506
32Chemical carcinogenesis_Homo sapiens_hsa052041.41533790
33Sulfur metabolism_Homo sapiens_hsa009201.41205613
34Rheumatoid arthritis_Homo sapiens_hsa053231.40434583
35PPAR signaling pathway_Homo sapiens_hsa033201.37803950
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.37485331
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.31889880
38Primary immunodeficiency_Homo sapiens_hsa053401.31613409
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28194938
40Malaria_Homo sapiens_hsa051441.26974516
41Herpes simplex infection_Homo sapiens_hsa051681.24255733
42Apoptosis_Homo sapiens_hsa042101.19263164
43ECM-receptor interaction_Homo sapiens_hsa045121.18379224
44Fatty acid biosynthesis_Homo sapiens_hsa000611.18005030
45Platelet activation_Homo sapiens_hsa046111.14516551
46Influenza A_Homo sapiens_hsa051641.14244304
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13127265
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12334447
49Tuberculosis_Homo sapiens_hsa051521.11379233
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10311546
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09732235
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09197240
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06163961
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05680397
55Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03570611
56Shigellosis_Homo sapiens_hsa051311.03243829
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02502373
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01356180
59Ribosome_Homo sapiens_hsa030100.99888645
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98893398
61Focal adhesion_Homo sapiens_hsa045100.98387486
62Arachidonic acid metabolism_Homo sapiens_hsa005900.96807079
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96748053
64Hepatitis B_Homo sapiens_hsa051610.95126112
65Chronic myeloid leukemia_Homo sapiens_hsa052200.94638916
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94597948
67Folate biosynthesis_Homo sapiens_hsa007900.93800168
68Salmonella infection_Homo sapiens_hsa051320.93503091
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93142032
70Hepatitis C_Homo sapiens_hsa051600.91711196
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91564340
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91401910
73Endocytosis_Homo sapiens_hsa041440.88649531
74ABC transporters_Homo sapiens_hsa020100.87967805
75TNF signaling pathway_Homo sapiens_hsa046680.87528783
76Protein digestion and absorption_Homo sapiens_hsa049740.87200303
77Fatty acid metabolism_Homo sapiens_hsa012120.86948448
78Fat digestion and absorption_Homo sapiens_hsa049750.85803138
79beta-Alanine metabolism_Homo sapiens_hsa004100.85656555
80Propanoate metabolism_Homo sapiens_hsa006400.85252106
81Collecting duct acid secretion_Homo sapiens_hsa049660.84203133
82p53 signaling pathway_Homo sapiens_hsa041150.81800369
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.79407179
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79248502
85Graft-versus-host disease_Homo sapiens_hsa053320.78441960
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.78195343
87Insulin resistance_Homo sapiens_hsa049310.77554189
88Adherens junction_Homo sapiens_hsa045200.77499726
89Amoebiasis_Homo sapiens_hsa051460.75699548
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.75425972
91Autoimmune thyroid disease_Homo sapiens_hsa053200.74975591
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74670421
93Tryptophan metabolism_Homo sapiens_hsa003800.72347462
94Acute myeloid leukemia_Homo sapiens_hsa052210.71888909
95Starch and sucrose metabolism_Homo sapiens_hsa005000.71182927
96Tyrosine metabolism_Homo sapiens_hsa003500.70882377
97Pancreatic cancer_Homo sapiens_hsa052120.70024572
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69932002
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68453771
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68032232
101Allograft rejection_Homo sapiens_hsa053300.67709130
102Proteoglycans in cancer_Homo sapiens_hsa052050.66291431
103Pentose phosphate pathway_Homo sapiens_hsa000300.64925977
104Asthma_Homo sapiens_hsa053100.64543417
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64167900
106Vibrio cholerae infection_Homo sapiens_hsa051100.63258616
107HTLV-I infection_Homo sapiens_hsa051660.62495863
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61954639
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57402711
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56341829
111HIF-1 signaling pathway_Homo sapiens_hsa040660.55823383
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55405312
113Lysine degradation_Homo sapiens_hsa003100.55399957
114Pancreatic secretion_Homo sapiens_hsa049720.53689091
115Chemokine signaling pathway_Homo sapiens_hsa040620.53669053
116Histidine metabolism_Homo sapiens_hsa003400.53438825
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53262231
118Glycerolipid metabolism_Homo sapiens_hsa005610.52869939
119Phenylalanine metabolism_Homo sapiens_hsa003600.52468332
120Systemic lupus erythematosus_Homo sapiens_hsa053220.50845555
121Galactose metabolism_Homo sapiens_hsa000520.50745639
122Non-homologous end-joining_Homo sapiens_hsa034500.49212693
123Viral carcinogenesis_Homo sapiens_hsa052030.48410531
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.48403970
125Nitrogen metabolism_Homo sapiens_hsa009100.47810711
126Epstein-Barr virus infection_Homo sapiens_hsa051690.46875178
127MicroRNAs in cancer_Homo sapiens_hsa052060.46465178
128Phagosome_Homo sapiens_hsa041450.46149528
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45763474
130Cell cycle_Homo sapiens_hsa041100.45553982
131Notch signaling pathway_Homo sapiens_hsa043300.44036327
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43669278
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43454733
134Mineral absorption_Homo sapiens_hsa049780.42639993
135Retinol metabolism_Homo sapiens_hsa008300.39939604
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38793144
137Fatty acid elongation_Homo sapiens_hsa000620.38600774

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