ARHGAP19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 17454002]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.49472002
2nuclear pore organization (GO:0006999)5.19464595
3nuclear pore complex assembly (GO:0051292)5.18927302
4mitotic sister chromatid segregation (GO:0000070)5.05116975
5protein localization to chromosome, centromeric region (GO:0071459)5.03983667
6sister chromatid segregation (GO:0000819)4.92559708
7DNA unwinding involved in DNA replication (GO:0006268)4.90265097
8mitotic chromosome condensation (GO:0007076)4.76646125
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.67586525
10mitotic sister chromatid cohesion (GO:0007064)4.48079604
11mitotic nuclear envelope disassembly (GO:0007077)4.42149953
12DNA replication-dependent nucleosome organization (GO:0034723)4.32709864
13DNA replication-dependent nucleosome assembly (GO:0006335)4.32709864
14pore complex assembly (GO:0046931)4.22717248
15kinetochore organization (GO:0051383)4.20330294
16positive regulation of chromosome segregation (GO:0051984)4.19819311
17DNA ligation (GO:0006266)4.18220364
18mitotic metaphase plate congression (GO:0007080)4.17572900
19establishment of integrated proviral latency (GO:0075713)4.14891292
20membrane disassembly (GO:0030397)4.13299805
21nuclear envelope disassembly (GO:0051081)4.13299805
22positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.11402096
23positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.11402096
24positive regulation of mitotic sister chromatid separation (GO:1901970)4.11402096
25attachment of spindle microtubules to kinetochore (GO:0008608)3.95863419
26regulation of histone H3-K9 methylation (GO:0051570)3.95504650
27DNA replication initiation (GO:0006270)3.93656984
28DNA strand elongation involved in DNA replication (GO:0006271)3.91835623
29regulation of spindle organization (GO:0090224)3.88053477
30DNA geometric change (GO:0032392)3.85276481
31DNA duplex unwinding (GO:0032508)3.83205165
32metaphase plate congression (GO:0051310)3.78616569
33meiotic chromosome segregation (GO:0045132)3.74687519
34regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.74188970
35DNA strand elongation (GO:0022616)3.72284101
36regulation of sister chromatid cohesion (GO:0007063)3.72076208
37regulation of chromosome segregation (GO:0051983)3.64595030
38protein localization to chromosome (GO:0034502)3.61524689
39establishment of chromosome localization (GO:0051303)3.58798092
40telomere maintenance via semi-conservative replication (GO:0032201)3.56782949
41chromosome condensation (GO:0030261)3.55500069
42mitotic recombination (GO:0006312)3.54186461
43heterochromatin organization (GO:0070828)3.53294465
44V(D)J recombination (GO:0033151)3.51484362
45chromatin remodeling at centromere (GO:0031055)3.51117581
46pre-miRNA processing (GO:0031054)3.49104863
47DNA replication checkpoint (GO:0000076)3.48775296
48DNA replication-independent nucleosome organization (GO:0034724)3.44770595
49DNA replication-independent nucleosome assembly (GO:0006336)3.44770595
50double-strand break repair via nonhomologous end joining (GO:0006303)3.44692900
51non-recombinational repair (GO:0000726)3.44692900
52telomere maintenance via recombination (GO:0000722)3.43244644
53mitotic G2/M transition checkpoint (GO:0044818)3.42811126
54CENP-A containing nucleosome assembly (GO:0034080)3.42494889
55chromosome segregation (GO:0007059)3.42371523
56negative regulation of histone methylation (GO:0031061)3.42279504
57kinetochore assembly (GO:0051382)3.42125402
58regulation of mitotic spindle organization (GO:0060236)3.41872343
59regulation of centrosome cycle (GO:0046605)3.41573009
60DNA conformation change (GO:0071103)3.39526890
61protein complex localization (GO:0031503)3.39038484
62translesion synthesis (GO:0019985)3.38647584
63chromatin assembly or disassembly (GO:0006333)3.36769979
64DNA synthesis involved in DNA repair (GO:0000731)3.35127592
65spindle checkpoint (GO:0031577)3.33784954
66chromatin assembly (GO:0031497)3.33568069
67regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.32124379
68regulation of mitotic metaphase/anaphase transition (GO:0030071)3.30903932
69folic acid-containing compound biosynthetic process (GO:0009396)3.28998374
70DNA topological change (GO:0006265)3.28325091
71histone exchange (GO:0043486)3.27139020
72negative regulation of chromosome segregation (GO:0051985)3.27019466
73regulation of centriole replication (GO:0046599)3.25388580
74nuclear envelope organization (GO:0006998)3.23831597
75microtubule depolymerization (GO:0007019)3.23586760
76regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.23060003
77spindle assembly checkpoint (GO:0071173)3.22614760
78regulation of DNA endoreduplication (GO:0032875)3.22343137
79DNA packaging (GO:0006323)3.20294658
80formation of translation preinitiation complex (GO:0001731)3.19263846
81IMP biosynthetic process (GO:0006188)3.17733305
82regulation of translational fidelity (GO:0006450)3.16056140
83regulation of sister chromatid segregation (GO:0033045)3.15633769
84regulation of mitotic sister chromatid separation (GO:0010965)3.15633769
85regulation of mitotic sister chromatid segregation (GO:0033047)3.15633769
86negative regulation of mitotic sister chromatid separation (GO:2000816)3.14753834
87negative regulation of mitotic sister chromatid segregation (GO:0033048)3.14753834
88negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.14753834
89negative regulation of sister chromatid segregation (GO:0033046)3.14753834
90purine nucleobase biosynthetic process (GO:0009113)3.12309113
91mitotic spindle assembly checkpoint (GO:0007094)3.09725833
92mitotic G2 DNA damage checkpoint (GO:0007095)3.09703284
93cellular protein complex localization (GO:0034629)3.09040024
94mitotic spindle checkpoint (GO:0071174)3.08493701
95negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.05077870
96protein K6-linked ubiquitination (GO:0085020)3.04317521
97postreplication repair (GO:0006301)3.00617669
98negative regulation of mRNA metabolic process (GO:1903312)2.99811174
99dosage compensation (GO:0007549)2.99702323
100establishment of viral latency (GO:0019043)2.98148725
101spindle assembly (GO:0051225)2.96084415
102regulation of RNA export from nucleus (GO:0046831)2.95670924
103ATP-dependent chromatin remodeling (GO:0043044)2.95184253
104nucleotide-excision repair, DNA gap filling (GO:0006297)2.94755942
105somatic diversification of immune receptors via somatic mutation (GO:0002566)2.93947308
106somatic hypermutation of immunoglobulin genes (GO:0016446)2.93947308
107regulation of telomere maintenance via telomerase (GO:0032210)2.93078925
108negative regulation of mitosis (GO:0045839)2.92264314
109negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.90085129
110protein-DNA complex disassembly (GO:0032986)2.89786440
111regulation of centrosome duplication (GO:0010824)2.86988852
112telomere maintenance via telomere lengthening (GO:0010833)2.86664575
113mRNA stabilization (GO:0048255)2.86138526
114RNA stabilization (GO:0043489)2.86138526
115spindle assembly involved in mitosis (GO:0090307)2.85689074
116regulation of gene silencing by miRNA (GO:0060964)2.85601513

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.86917553
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.44128727
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.77623438
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.11351396
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.99537577
6* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.90553706
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81059106
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.41724361
9AR_21909140_ChIP-Seq_LNCAP_Human2.41589616
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.29052629
11* E2F1_21310950_ChIP-Seq_MCF-7_Human2.21582432
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20769648
13MYC_22102868_ChIP-Seq_BL_Human2.01608033
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01361970
15E2F7_22180533_ChIP-Seq_HELA_Human10.4023588
16* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98467411
17MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92410432
18MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76818212
19XRN2_22483619_ChIP-Seq_HELA_Human1.75408245
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.68688986
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.64184588
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60702189
23CIITA_25753668_ChIP-Seq_RAJI_Human1.59014582
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57895112
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57510931
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57105579
27VDR_21846776_ChIP-Seq_THP-1_Human1.57076030
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55310618
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.50077299
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.50029305
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48391869
32VDR_23849224_ChIP-Seq_CD4+_Human1.48336331
33FOXP3_21729870_ChIP-Seq_TREG_Human1.47344717
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45280533
35KDM5A_27292631_Chip-Seq_BREAST_Human1.42296295
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39419404
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39007966
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38930893
39PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38002788
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33973232
41TFEB_21752829_ChIP-Seq_HELA_Human1.30778115
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30307524
43TTF2_22483619_ChIP-Seq_HELA_Human1.30032722
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28686583
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28152999
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.27453191
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.24841386
48KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24220629
49GABP_19822575_ChIP-Seq_HepG2_Human1.22965982
50GATA1_22025678_ChIP-Seq_K562_Human1.22687899
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21834658
52DCP1A_22483619_ChIP-Seq_HELA_Human1.21784631
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21166982
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20773085
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19844550
56ELK1_19687146_ChIP-ChIP_HELA_Human1.19733053
57SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.17417242
58* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17398371
59GABP_17652178_ChIP-ChIP_JURKAT_Human1.16971791
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15743753
61* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15680311
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15529172
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12433800
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11394228
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11225876
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11219496
67* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10843015
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08851576
69* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07824758
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07232386
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06624993
72KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06114937
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06114937
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06114937
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06105739
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05685713
77CHD1_26751641_Chip-Seq_LNCaP_Human1.04660521
78* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04072847
79SPI1_23547873_ChIP-Seq_NB4_Human1.03280724
80NANOG_21062744_ChIP-ChIP_HESCs_Human1.01962113
81PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98976569
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97047720
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96684243
84SOX2_16153702_ChIP-ChIP_HESCs_Human0.96195027
85* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96169497
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95459208
87WT1_19549856_ChIP-ChIP_CCG9911_Human0.94372469
88TCF7_22412390_ChIP-Seq_EML_Mouse0.93879898
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93696741
90ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91954315
91NCOR1_26117541_ChIP-Seq_K562_Human0.91136627
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91062749
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90569084
94UTX_26944678_Chip-Seq_JUKART_Human0.89539524
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88066804
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87871104
97MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87298888
98CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84415669
99MYB_26560356_Chip-Seq_TH1_Human0.84355130
100ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84030763
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83553273
102SCL_19346495_ChIP-Seq_HPC-7_Human0.83264286
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82979820
104* NANOG_16153702_ChIP-ChIP_HESCs_Human0.81589503
105MAF_26560356_Chip-Seq_TH1_Human0.81302400
106RUNX1_22412390_ChIP-Seq_EML_Mouse0.81211080
107YY1_21170310_ChIP-Seq_MESCs_Mouse0.81050119
108SOX17_20123909_ChIP-Seq_XEN_Mouse0.79833931
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79397391
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79240268
111MYB_26560356_Chip-Seq_TH2_Human0.79068531
112NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.79009681
113TCF3_18692474_ChIP-Seq_MEFs_Mouse0.78172736
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.77978735
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.77213591
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.77196189

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.43977229
2MP0003111_abnormal_nucleus_morphology4.40528790
3MP0003693_abnormal_embryo_hatching4.34639002
4MP0008057_abnormal_DNA_replication3.88936811
5MP0003077_abnormal_cell_cycle3.68020382
6MP0004957_abnormal_blastocyst_morpholog3.45173322
7MP0002009_preneoplasia3.01223385
8MP0010307_abnormal_tumor_latency2.91690702
9MP0000569_abnormal_digit_pigmentation2.59568326
10MP0008058_abnormal_DNA_repair2.49299089
11MP0008007_abnormal_cellular_replicative2.30549126
12MP0008877_abnormal_DNA_methylation2.29854073
13MP0010352_gastrointestinal_tract_polyps2.25658890
14MP0001730_embryonic_growth_arrest2.25286196
15MP0005076_abnormal_cell_differentiation2.20832015
16MP0008932_abnormal_embryonic_tissue2.20266614
17MP0002396_abnormal_hematopoietic_system2.15431908
18MP0000350_abnormal_cell_proliferation2.15034200
19MP0003123_paternal_imprinting2.03748543
20MP0006292_abnormal_olfactory_placode1.82830693
21MP0005380_embryogenesis_phenotype1.79005976
22MP0001672_abnormal_embryogenesis/_devel1.79005976
23MP0009278_abnormal_bone_marrow1.71929058
24MP0001697_abnormal_embryo_size1.71271924
25MP0004197_abnormal_fetal_growth/weight/1.63214785
26MP0004808_abnormal_hematopoietic_stem1.62525319
27MP0003984_embryonic_growth_retardation1.60264507
28MP0002084_abnormal_developmental_patter1.59019484
29MP0003718_maternal_effect1.58461695
30MP0002085_abnormal_embryonic_tissue1.57810531
31MP0002088_abnormal_embryonic_growth/wei1.57482608
32MP0002877_abnormal_melanocyte_morpholog1.55877627
33MP0002086_abnormal_extraembryonic_tissu1.55824658
34MP0009697_abnormal_copulation1.55440322
35MP0000490_abnormal_crypts_of1.52723085
36MP0002080_prenatal_lethality1.52641153
37MP0003221_abnormal_cardiomyocyte_apopto1.50422013
38MP0003121_genomic_imprinting1.48899585
39MP0003705_abnormal_hypodermis_morpholog1.41570359
40MP0003315_abnormal_perineum_morphology1.41160829
41MP0003567_abnormal_fetal_cardiomyocyte1.40080767
42MP0000313_abnormal_cell_death1.37150845
43MP0003786_premature_aging1.35817046
44MP0004185_abnormal_adipocyte_glucose1.34994520
45MP0005397_hematopoietic_system_phenotyp1.32249069
46MP0001545_abnormal_hematopoietic_system1.32249069
47MP0003890_abnormal_embryonic-extraembry1.31520127
48MP0002210_abnormal_sex_determination1.30765007
49MP0002019_abnormal_tumor_incidence1.27085739
50MP0005174_abnormal_tail_pigmentation1.26756758
51MP0001929_abnormal_gametogenesis1.24448083
52MP0003566_abnormal_cell_adhesion1.20064444
53MP0001145_abnormal_male_reproductive1.17335362
54MP0000703_abnormal_thymus_morphology1.12972290
55MP0001915_intracranial_hemorrhage1.11410938
56MP0001293_anophthalmia1.09792703
57MP0002398_abnormal_bone_marrow1.08717959
58MP0004147_increased_porphyrin_level1.05495041
59MP0004233_abnormal_muscle_weight1.03784490
60MP0001286_abnormal_eye_development1.03502877
61MP0002722_abnormal_immune_system1.01631675
62MP0002166_altered_tumor_susceptibility1.01612218
63MP0000689_abnormal_spleen_morphology0.99779866
64MP0001849_ear_inflammation0.95781560
65MP0003303_peritoneal_inflammation0.94123795
66MP0009703_decreased_birth_body0.93439578
67MP0000733_abnormal_muscle_development0.91949039
68MP0002006_tumorigenesis0.91612423
69MP0009053_abnormal_anal_canal0.91586672
70MP0006035_abnormal_mitochondrial_morpho0.91364180
71MP0008260_abnormal_autophagy0.91241142
72MP0009672_abnormal_birth_weight0.90731521
73MP0000653_abnormal_sex_gland0.90108248
74MP0000537_abnormal_urethra_morphology0.89683752
75MP0010030_abnormal_orbit_morphology0.89322066
76MP0005621_abnormal_cell_physiology0.89042771
77MP0003136_yellow_coat_color0.88878622
78MP0003448_altered_tumor_morphology0.88170048
79MP0003941_abnormal_skin_development0.87977281
80MP0003698_abnormal_male_reproductive0.86879112
81MP0005384_cellular_phenotype0.86357815
82MP0008995_early_reproductive_senescence0.86000677
83MP0000858_altered_metastatic_potential0.85388130
84MP0000566_synostosis0.84884412
85MP0002429_abnormal_blood_cell0.82162828
86MP0003172_abnormal_lysosome_physiology0.82122698
87MP0004272_abnormal_basement_membrane0.81964055
88MP0002653_abnormal_ependyma_morphology0.81392891
89MP0003656_abnormal_erythrocyte_physiolo0.80803076
90MP0002075_abnormal_coat/hair_pigmentati0.79496532
91MP0000371_diluted_coat_color0.79203488
92MP0009333_abnormal_splenocyte_physiolog0.76473134
93MP0002095_abnormal_skin_pigmentation0.76407297
94MP0000015_abnormal_ear_pigmentation0.75363697
95MP0005023_abnormal_wound_healing0.75161664
96MP0002697_abnormal_eye_size0.74700240
97MP0003861_abnormal_nervous_system0.74688265
98MP0002092_abnormal_eye_morphology0.74488508
99MP0005394_taste/olfaction_phenotype0.73840053
100MP0005499_abnormal_olfactory_system0.73840053
101MP0005410_abnormal_fertilization0.72082381
102MP0002111_abnormal_tail_morphology0.71813736
103MP0000428_abnormal_craniofacial_morphol0.71112504
104MP0001346_abnormal_lacrimal_gland0.71068591
105MP0000716_abnormal_immune_system0.71053516
106MP0004264_abnormal_extraembryonic_tissu0.70242059
107MP0008789_abnormal_olfactory_epithelium0.70027118
108MP0003943_abnormal_hepatobiliary_system0.69664648
109MP0002925_abnormal_cardiovascular_devel0.69289747
110MP0005058_abnormal_lysosome_morphology0.69245606
111MP0003937_abnormal_limbs/digits/tail_de0.68404550
112MP0005075_abnormal_melanosome_morpholog0.67645551
113MP0000432_abnormal_head_morphology0.67581476
114MP0002405_respiratory_system_inflammati0.65834422
115MP0004381_abnormal_hair_follicle0.64945272
116MP0001727_abnormal_embryo_implantation0.64693241
117MP0001119_abnormal_female_reproductive0.64654160
118MP0003119_abnormal_digestive_system0.64114149
119MP0001800_abnormal_humoral_immune0.63889548
120MP0002233_abnormal_nose_morphology0.63539279
121MP0003699_abnormal_female_reproductive0.63295125
122MP0002161_abnormal_fertility/fecundity0.63138868
123MP0002452_abnormal_antigen_presenting0.62477042
124MP0000358_abnormal_cell_content/0.62251130
125MP0008770_decreased_survivor_rate0.62063519
126MP0003935_abnormal_craniofacial_develop0.61757996
127MP0005464_abnormal_platelet_physiology0.61273320
128MP0003763_abnormal_thymus_physiology0.61024955
129MP0005623_abnormal_meninges_morphology0.60344697
130MP0002938_white_spotting0.57810484
131MP0010630_abnormal_cardiac_muscle0.57688678
132MP0003115_abnormal_respiratory_system0.52822394

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)5.62235345
2Segmental peripheral demyelination/remyelination (HP:0003481)4.87604598
3Impaired proprioception (HP:0010831)4.70166461
4Insidious onset (HP:0003587)4.26227334
5Termporal pattern (HP:0011008)4.26227334
6Chromsome breakage (HP:0040012)4.08863826
7Cortical dysplasia (HP:0002539)4.01313080
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.96672788
9Increased CSF protein (HP:0002922)3.41949845
10Ependymoma (HP:0002888)3.39624436
11Upper limb muscle weakness (HP:0003484)3.28891753
12Agnosia (HP:0010524)3.17475985
13Volvulus (HP:0002580)3.11396483
14Abnormality of chromosome stability (HP:0003220)3.03790475
15Impulsivity (HP:0100710)2.92592996
16Increased nuchal translucency (HP:0010880)2.92078890
17Selective tooth agenesis (HP:0001592)2.89990282
18Ectopic kidney (HP:0000086)2.85057172
19High anterior hairline (HP:0009890)2.83410633
20Meckel diverticulum (HP:0002245)2.72412565
21Medulloblastoma (HP:0002885)2.68886200
22Small intestinal stenosis (HP:0012848)2.68293206
23Duodenal stenosis (HP:0100867)2.68293206
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.67899209
25Abnormality of the ileum (HP:0001549)2.65761106
26Reticulocytopenia (HP:0001896)2.64308557
27Astrocytoma (HP:0009592)2.56760800
28Abnormality of the astrocytes (HP:0100707)2.56760800
29Deep philtrum (HP:0002002)2.55922805
30Prominent nose (HP:0000448)2.49150648
31Acute myeloid leukemia (HP:0004808)2.47791657
32Myelodysplasia (HP:0002863)2.47778284
33Birth length less than 3rd percentile (HP:0003561)2.45254853
34High pitched voice (HP:0001620)2.44308783
35Leiomyosarcoma (HP:0100243)2.43532805
36Uterine leiomyosarcoma (HP:0002891)2.43532805
37Abnormality of the preputium (HP:0100587)2.42032814
38Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.41364236
39Short 4th metacarpal (HP:0010044)2.41364236
40Embryonal neoplasm (HP:0002898)2.40227703
41Proximal placement of thumb (HP:0009623)2.38220471
42Neoplasm of the oral cavity (HP:0100649)2.35845718
43Progressive external ophthalmoplegia (HP:0000590)2.35679487
44Abnormality of cochlea (HP:0000375)2.33764187
45Combined immunodeficiency (HP:0005387)2.33210997
46Degeneration of anterior horn cells (HP:0002398)2.30408230
47Abnormality of the anterior horn cell (HP:0006802)2.30408230
48Deviation of the thumb (HP:0009603)2.29116433
49Peripheral demyelination (HP:0011096)2.27620660
50Patellar aplasia (HP:0006443)2.25538847
51Basal cell carcinoma (HP:0002671)2.25477324
52Multiple enchondromatosis (HP:0005701)2.22774292
53Transitional cell carcinoma of the bladder (HP:0006740)2.22740461
54Abnormality of the carotid arteries (HP:0005344)2.22434125
55Rhabdomyosarcoma (HP:0002859)2.19495086
56Cafe-au-lait spot (HP:0000957)2.19349332
57Ankyloglossia (HP:0010296)2.18828486
58IgM deficiency (HP:0002850)2.15533423
59Abnormality of the duodenum (HP:0002246)2.15050356
60Sloping forehead (HP:0000340)2.14566771
61Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.14427341
62Colon cancer (HP:0003003)2.13731243
63Heterotopia (HP:0002282)2.12531614
64Duplicated collecting system (HP:0000081)2.12470254
65Neoplasm of the colon (HP:0100273)2.11896325
66Glioma (HP:0009733)2.10637074
67Aplasia/Hypoplasia of the sternum (HP:0006714)2.10050817
68Bladder neoplasm (HP:0009725)2.09513832
69Bladder carcinoma (HP:0002862)2.09513832
70Aplasia/Hypoplasia of the patella (HP:0006498)2.05157593
71Absent thumb (HP:0009777)2.04463258
72Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.01718881
73Abnormal gallbladder physiology (HP:0012438)2.00056313
74Cholecystitis (HP:0001082)2.00056313
75Cutaneous melanoma (HP:0012056)1.98778874
76Horseshoe kidney (HP:0000085)1.97569226
77Arteriovenous malformation (HP:0100026)1.94133815
78Choanal atresia (HP:0000453)1.93907745
79Nephroblastoma (Wilms tumor) (HP:0002667)1.93884352
80Pallor (HP:0000980)1.93060172
81Abnormal number of incisors (HP:0011064)1.92049759
82Bone marrow hypocellularity (HP:0005528)1.91914684
83Carpal bone hypoplasia (HP:0001498)1.91761174
84Abnormality of the labia minora (HP:0012880)1.91312160
85Missing ribs (HP:0000921)1.91273024
86Breast hypoplasia (HP:0003187)1.89703553
87Decreased motor nerve conduction velocity (HP:0003431)1.88610418
88Tracheoesophageal fistula (HP:0002575)1.87874538
89Anal stenosis (HP:0002025)1.87741846
90Neoplasm of striated muscle (HP:0009728)1.87201627
91Renovascular hypertension (HP:0100817)1.86982386
92Uterine neoplasm (HP:0010784)1.86727126
93Long eyelashes (HP:0000527)1.86644017
94Duplication of thumb phalanx (HP:0009942)1.86607717
95Abnormality of the renal collecting system (HP:0004742)1.84617207
96Triphalangeal thumb (HP:0001199)1.83836911
97Skull defect (HP:0001362)1.83380978
98Absent radius (HP:0003974)1.83245969
99Abnormality of the fingertips (HP:0001211)1.81609974
100Abnormal lung lobation (HP:0002101)1.81576334
101Neoplasm of the pancreas (HP:0002894)1.80253572
102Spinal muscular atrophy (HP:0007269)1.79576386
103Acute lymphatic leukemia (HP:0006721)1.79336167
104Squamous cell carcinoma (HP:0002860)1.78895373
105Overlapping toe (HP:0001845)1.78833401
106Obsessive-compulsive behavior (HP:0000722)1.78461587
107Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77392693
108Abnormality of oral frenula (HP:0000190)1.76799454
109Progressive sensorineural hearing impairment (HP:0000408)1.76383117
110Facial hemangioma (HP:0000329)1.76026356
111Embryonal renal neoplasm (HP:0011794)1.75661504
112Intestinal fistula (HP:0100819)1.75604824
11311 pairs of ribs (HP:0000878)1.75185285
114Hyperacusis (HP:0010780)1.75060635
115Malignant gastrointestinal tract tumors (HP:0006749)1.74986397
116Gastrointestinal carcinoma (HP:0002672)1.74986397
117Recurrent abscess formation (HP:0002722)1.74984438
118Renal duplication (HP:0000075)1.74650875
119Supernumerary spleens (HP:0009799)1.74181708
120Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73538191
121Abnormality of reticulocytes (HP:0004312)1.73512189
122Action tremor (HP:0002345)1.73353057
123Abnormality of homocysteine metabolism (HP:0010919)1.73280785
124Homocystinuria (HP:0002156)1.73280785
125Clubbing of toes (HP:0100760)1.71883328
126Aplasia/hypoplasia of the humerus (HP:0006507)1.71505900
127Capillary hemangiomas (HP:0005306)1.70487596
128Papillary thyroid carcinoma (HP:0002895)1.70098905
129Abnormality of DNA repair (HP:0003254)1.69839889
130Peripheral hypomyelination (HP:0007182)1.68603835
131Abnormality of chromosome segregation (HP:0002916)1.68454311
132Lymphoma (HP:0002665)1.68272466
133Sandal gap (HP:0001852)1.68122216
134Biliary tract neoplasm (HP:0100574)1.67832423
135Foot dorsiflexor weakness (HP:0009027)1.67358566
136Aplasia/Hypoplasia of the thymus (HP:0010515)1.67085431
137Aplasia involving forearm bones (HP:0009822)1.66385835
138Absent forearm bone (HP:0003953)1.66385835
139Spastic diplegia (HP:0001264)1.66138243
140Progressive hearing impairment (HP:0001730)1.65662534
141Atresia of the external auditory canal (HP:0000413)1.65513487
142Abnormality of the heme biosynthetic pathway (HP:0010472)1.65072297
143Neoplasm of the small intestine (HP:0100833)1.64660154
144Short middle phalanx of the 5th finger (HP:0004220)1.64443168
145Ovarian neoplasm (HP:0100615)1.63239130
146Neoplasm of the adrenal cortex (HP:0100641)1.62130441
147Cutis marmorata (HP:0000965)1.59741379

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.55399875
2NEK23.85614841
3CDK123.82092673
4BUB13.28045143
5WEE13.17620868
6TTK2.78132882
7EEF2K2.51380965
8STK102.17315293
9PLK11.94326232
10NEK11.93499313
11ATR1.91056987
12MAP3K101.83673541
13SMG11.74457847
14PBK1.73234430
15AURKB1.70460088
16CDK71.65695732
17CDK41.65617413
18SRPK11.64845927
19CDK61.63512247
20EIF2AK11.62524792
21BRD41.62520339
22STK41.60599885
23CHEK21.60310706
24TAF11.59909529
25PASK1.59571197
26TESK21.57552067
27PKN21.54988628
28PRPF4B1.52811273
29MAP3K81.52777516
30RPS6KB21.49315731
31BRSK21.49313221
32CHEK11.49027995
33ICK1.44122617
34PAK41.42116779
35PLK41.40538503
36TSSK61.34258386
37PLK31.33978712
38SCYL21.32616716
39TLK11.27125236
40STK31.25618792
41VRK21.25317608
42ACVR1B1.21293790
43ATM1.16371473
44MKNK11.16008906
45STK241.14707663
46KSR21.09649677
47PIM11.09230633
48AURKA1.05043306
49TESK11.01587709
50BRSK11.01529495
51DYRK31.01522410
52RIPK40.98583887
53CLK10.96867330
54* CDK20.96427518
55MTOR0.96364300
56PDK40.93201217
57PDK30.93201217
58RPS6KA40.91186988
59TTN0.90943936
60CDK190.90579900
61MAP4K10.90505070
62EIF2AK20.90186005
63ALK0.89705588
64CAMK1D0.89425572
65TRIB30.88290559
66MELK0.84798773
67VRK10.83709163
68BRAF0.83444875
69KSR10.82298965
70MKNK20.81692619
71CDK10.79031073
72LRRK20.73191224
73PNCK0.71341218
74ZAK0.70780528
75GRK60.70554370
76PTK60.69856525
77TNIK0.69842785
78MAP3K140.68979778
79IRAK40.67963262
80FLT30.67780208
81EPHA20.64868583
82TGFBR10.63553538
83WNK10.63322097
84CSF1R0.60469820
85RAF10.59652439
86YES10.58587737
87MARK30.58331410
88PAK10.55483500
89NUAK10.54020579
90LATS10.53806105
91FGFR10.52475962
92MAP2K30.52130266
93CAMK1G0.52015584
94BTK0.51624099
95FGR0.51006221
96CDK90.47937327
97CSNK2A20.47295584
98PRKDC0.46210892
99AKT20.45993621
100NLK0.45395861
101CCNB10.44500898
102CSNK1D0.43351007
103MAPK140.42658476
104PAK20.42222826
105NEK90.39236375
106SIK20.38845778
107CSNK2A10.37813564
108TEC0.36652567
109BMX0.36468194
110MAP3K20.35587305
111TRPM70.35553309
112AKT10.35204562
113RPS6KL10.34260491
114RPS6KC10.34260491
115EIF2AK30.33889101
116MST40.33112060
117DYRK1B0.32529136
118CSK0.32504247
119ZAP700.31658453
120MAPK10.31275306
121LATS20.30850368
122MAPK110.29863552
123BLK0.29794113
124CDK30.29383191
125PDK20.27990587
126TRIM280.27790765
127IRAK20.26840327
128JAK30.26445773
129KIT0.26212593
130JAK20.25854323
131GSK3B0.25325462
132CDK11A0.24706929
133CDK80.23502838
134CDK150.22296464

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.47727463
2Mismatch repair_Homo sapiens_hsa034303.87567674
3Cell cycle_Homo sapiens_hsa041103.15703509
4RNA transport_Homo sapiens_hsa030132.99314556
5Spliceosome_Homo sapiens_hsa030402.86308831
6Base excision repair_Homo sapiens_hsa034102.83561864
7Homologous recombination_Homo sapiens_hsa034402.81534280
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73010854
9One carbon pool by folate_Homo sapiens_hsa006702.69144553
10Fanconi anemia pathway_Homo sapiens_hsa034602.63681063
11Nucleotide excision repair_Homo sapiens_hsa034202.40902551
12Non-homologous end-joining_Homo sapiens_hsa034502.22088167
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.17610640
14mRNA surveillance pathway_Homo sapiens_hsa030152.07677566
15Systemic lupus erythematosus_Homo sapiens_hsa053221.87314246
16p53 signaling pathway_Homo sapiens_hsa041151.72166516
17RNA degradation_Homo sapiens_hsa030181.55556218
18Viral carcinogenesis_Homo sapiens_hsa052031.46280658
19Basal transcription factors_Homo sapiens_hsa030221.44308720
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.40134446
21Ribosome_Homo sapiens_hsa030101.32373064
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31898149
23Pyrimidine metabolism_Homo sapiens_hsa002401.30980423
24Oocyte meiosis_Homo sapiens_hsa041141.30410407
25RNA polymerase_Homo sapiens_hsa030201.30161789
26Small cell lung cancer_Homo sapiens_hsa052221.28844257
27MicroRNAs in cancer_Homo sapiens_hsa052061.24965328
28Antigen processing and presentation_Homo sapiens_hsa046121.20991879
29Epstein-Barr virus infection_Homo sapiens_hsa051691.12144496
30Chronic myeloid leukemia_Homo sapiens_hsa052201.09754034
31Herpes simplex infection_Homo sapiens_hsa051681.09061472
32HTLV-I infection_Homo sapiens_hsa051661.04439098
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97519608
34Proteasome_Homo sapiens_hsa030500.96778288
35Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96362872
36Viral myocarditis_Homo sapiens_hsa054160.92869001
37Selenocompound metabolism_Homo sapiens_hsa004500.88430414
38Lysine degradation_Homo sapiens_hsa003100.87524987
39Apoptosis_Homo sapiens_hsa042100.84269723
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83197883
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83073654
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82233770
43Pentose phosphate pathway_Homo sapiens_hsa000300.80135946
44mTOR signaling pathway_Homo sapiens_hsa041500.79798604
45Renal cell carcinoma_Homo sapiens_hsa052110.79066275
46Legionellosis_Homo sapiens_hsa051340.78842977
47Colorectal cancer_Homo sapiens_hsa052100.77907270
48Notch signaling pathway_Homo sapiens_hsa043300.77904457
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76541034
50B cell receptor signaling pathway_Homo sapiens_hsa046620.75302405
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.74524477
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72510292
53Hepatitis B_Homo sapiens_hsa051610.72005455
54Vitamin B6 metabolism_Homo sapiens_hsa007500.71527307
55Steroid biosynthesis_Homo sapiens_hsa001000.71223197
56Thyroid cancer_Homo sapiens_hsa052160.70457989
57Carbon metabolism_Homo sapiens_hsa012000.69785550
58Alcoholism_Homo sapiens_hsa050340.69476355
59Non-small cell lung cancer_Homo sapiens_hsa052230.69137920
60Adherens junction_Homo sapiens_hsa045200.68485705
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67717260
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.65041301
63Measles_Homo sapiens_hsa051620.63911614
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63129779
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62397315
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.62330458
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.61641039
68Leishmaniasis_Homo sapiens_hsa051400.61025691
69Pancreatic cancer_Homo sapiens_hsa052120.60091719
70Basal cell carcinoma_Homo sapiens_hsa052170.58060433
71Toxoplasmosis_Homo sapiens_hsa051450.57690378
72Glioma_Homo sapiens_hsa052140.57329253
73Biosynthesis of amino acids_Homo sapiens_hsa012300.57118519
74Purine metabolism_Homo sapiens_hsa002300.55035980
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.54415736
76Wnt signaling pathway_Homo sapiens_hsa043100.53824143
77Hippo signaling pathway_Homo sapiens_hsa043900.53495985
78Shigellosis_Homo sapiens_hsa051310.53400436
79Pyruvate metabolism_Homo sapiens_hsa006200.52887022
80Influenza A_Homo sapiens_hsa051640.52700422
81Acute myeloid leukemia_Homo sapiens_hsa052210.52482275
82TGF-beta signaling pathway_Homo sapiens_hsa043500.52040166
83Primary immunodeficiency_Homo sapiens_hsa053400.50715246
84HIF-1 signaling pathway_Homo sapiens_hsa040660.50587036
85Prostate cancer_Homo sapiens_hsa052150.50542196
86Proteoglycans in cancer_Homo sapiens_hsa052050.50383365
87ErbB signaling pathway_Homo sapiens_hsa040120.50100784
88Pathways in cancer_Homo sapiens_hsa052000.49872571
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49674193
90Bladder cancer_Homo sapiens_hsa052190.49523510
91Dorso-ventral axis formation_Homo sapiens_hsa043200.47583651
92Hematopoietic cell lineage_Homo sapiens_hsa046400.47477560
93Hedgehog signaling pathway_Homo sapiens_hsa043400.47085708
94Endometrial cancer_Homo sapiens_hsa052130.46277802
95Osteoclast differentiation_Homo sapiens_hsa043800.46233508
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44244936
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43830162
98Prolactin signaling pathway_Homo sapiens_hsa049170.43060087
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41705059
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.40996929
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40931117
102Inositol phosphate metabolism_Homo sapiens_hsa005620.40816020
103Insulin signaling pathway_Homo sapiens_hsa049100.38626867
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37778520
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36376304
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36213655
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35539587
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35233824
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35174560
110Renin-angiotensin system_Homo sapiens_hsa046140.34761504
111VEGF signaling pathway_Homo sapiens_hsa043700.32931844
112FoxO signaling pathway_Homo sapiens_hsa040680.32700317
113Focal adhesion_Homo sapiens_hsa045100.32351981
114Melanoma_Homo sapiens_hsa052180.31562197
115ECM-receptor interaction_Homo sapiens_hsa045120.31074205
116N-Glycan biosynthesis_Homo sapiens_hsa005100.30609038
117T cell receptor signaling pathway_Homo sapiens_hsa046600.30350254
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29856627
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28011916
120AMPK signaling pathway_Homo sapiens_hsa041520.27517916

Most similar genes based on co-expression Upload to Enrichr

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