ARHGAP21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.19282568
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.10136514
3synaptic vesicle maturation (GO:0016188)4.74053743
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.63682828
5vocalization behavior (GO:0071625)4.58968459
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.48971805
7presynaptic membrane assembly (GO:0097105)4.47595384
8axon ensheathment in central nervous system (GO:0032291)4.36477943
9central nervous system myelination (GO:0022010)4.36477943
10presynaptic membrane organization (GO:0097090)4.33192250
11postsynaptic membrane organization (GO:0001941)4.29741916
12layer formation in cerebral cortex (GO:0021819)4.27656147
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.23236167
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.20939869
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.14858627
16cerebellar Purkinje cell differentiation (GO:0021702)4.11547431
17glutamate secretion (GO:0014047)4.03820371
18cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.98801925
19sodium ion export (GO:0071436)3.92822696
20regulation of glutamate receptor signaling pathway (GO:1900449)3.90810755
21cerebellar granule cell differentiation (GO:0021707)3.90705044
22glutamate receptor signaling pathway (GO:0007215)3.80638193
23cellular potassium ion homeostasis (GO:0030007)3.80020090
24cell communication by electrical coupling (GO:0010644)3.79572296
25positive regulation of synapse maturation (GO:0090129)3.72453170
26synaptic vesicle exocytosis (GO:0016079)3.71750163
27synaptic transmission, glutamatergic (GO:0035249)3.70886969
28exploration behavior (GO:0035640)3.68844727
29L-amino acid import (GO:0043092)3.66125564
30neuronal action potential propagation (GO:0019227)3.63903540
31establishment of nucleus localization (GO:0040023)3.63846331
32regulation of synaptic vesicle exocytosis (GO:2000300)3.63808726
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.58526262
34regulation of neuronal synaptic plasticity (GO:0048168)3.57324275
35dendritic spine morphogenesis (GO:0060997)3.55728907
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.52596007
37gamma-aminobutyric acid transport (GO:0015812)3.52235094
38regulation of synapse structural plasticity (GO:0051823)3.51493140
39amino acid import (GO:0043090)3.51391672
40neurotransmitter secretion (GO:0007269)3.50921412
41dendrite morphogenesis (GO:0048813)3.42683309
42protein localization to synapse (GO:0035418)3.41351470
43long-term memory (GO:0007616)3.38613540
44positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.34548868
45proline transport (GO:0015824)3.33050325
46neuron cell-cell adhesion (GO:0007158)3.28867393
47membrane assembly (GO:0071709)3.28537730
48neuromuscular process controlling balance (GO:0050885)3.27034241
49regulation of synaptic vesicle transport (GO:1902803)3.24271539
50neuron-neuron synaptic transmission (GO:0007270)3.22726398
51axonal fasciculation (GO:0007413)3.22239937
52cytoskeletal anchoring at plasma membrane (GO:0007016)3.21873041
53cell differentiation in hindbrain (GO:0021533)3.19959640
54cell migration in hindbrain (GO:0021535)3.13237695
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.12591834
56regulation of excitatory postsynaptic membrane potential (GO:0060079)3.12070836
57cerebral cortex radially oriented cell migration (GO:0021799)3.10801887
58cell communication involved in cardiac conduction (GO:0086065)3.10314341
59neuron recognition (GO:0008038)3.09657486
60neurotransmitter-gated ion channel clustering (GO:0072578)3.09349577
61regulation of dendritic spine morphogenesis (GO:0061001)3.08743710
62pyrimidine nucleobase catabolic process (GO:0006208)3.08300202
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.07100843
64activation of protein kinase A activity (GO:0034199)3.04473070
65synaptic vesicle endocytosis (GO:0048488)3.02035684
66regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.99905390
67establishment of mitochondrion localization (GO:0051654)2.99711342
68regulation of postsynaptic membrane potential (GO:0060078)2.98520820
69membrane depolarization during action potential (GO:0086010)2.95733442
70innervation (GO:0060384)2.95663438
71astrocyte development (GO:0014002)2.92436405
72long-chain fatty acid biosynthetic process (GO:0042759)2.91756633
73regulation of clathrin-mediated endocytosis (GO:2000369)2.89849456
74auditory behavior (GO:0031223)2.84183271
75cellular sodium ion homeostasis (GO:0006883)2.83690499
76regulation of ARF protein signal transduction (GO:0032012)2.83191689
77positive regulation of dendritic spine development (GO:0060999)2.82858401
78regulation of synaptic plasticity (GO:0048167)2.81269456
79regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.79641483
80potassium ion import (GO:0010107)2.79584146
81central nervous system projection neuron axonogenesis (GO:0021952)2.79255393
82axon extension (GO:0048675)2.78189329
83regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.78017800
84regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.76941325
85positive regulation of potassium ion transmembrane transport (GO:1901381)2.76638656
86positive regulation of membrane potential (GO:0045838)2.75313912
87myelination (GO:0042552)2.74829737
88neurotransmitter transport (GO:0006836)2.74572936
89regulation of synapse maturation (GO:0090128)2.73677542
90chemosensory behavior (GO:0007635)2.73371704
91negative regulation of hormone biosynthetic process (GO:0032353)2.72645466
92negative regulation of hormone metabolic process (GO:0032351)2.72645466
93response to pheromone (GO:0019236)2.71378903
94myelination in peripheral nervous system (GO:0022011)2.69830237
95peripheral nervous system axon ensheathment (GO:0032292)2.69830237
96negative regulation of synaptic transmission, GABAergic (GO:0032229)2.68615277
97gamma-aminobutyric acid signaling pathway (GO:0007214)2.68592539
98dendritic spine organization (GO:0097061)2.68436892
99glycine transport (GO:0015816)2.67557312
100membrane depolarization (GO:0051899)2.67466159
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.67227239
102axon ensheathment (GO:0008366)2.67117161
103ensheathment of neurons (GO:0007272)2.67117161
104embryonic retina morphogenesis in camera-type eye (GO:0060059)2.66597385
105negative regulation of dendrite morphogenesis (GO:0050774)2.65905716
106negative regulation of neurotransmitter secretion (GO:0046929)2.64300797
107regulation of axon extension involved in axon guidance (GO:0048841)2.63900548
108neuromuscular process (GO:0050905)2.62893036
109nerve growth factor signaling pathway (GO:0038180)2.62701294
110positive regulation of dendritic spine morphogenesis (GO:0061003)2.62608597
111regulation of neurotransmitter secretion (GO:0046928)2.61872362
112positive regulation of synapse assembly (GO:0051965)2.61420613
113membrane repolarization (GO:0086009)2.61368994
114regulation of synaptic transmission, glutamatergic (GO:0051966)2.60954362
115transmission of nerve impulse (GO:0019226)2.60894191
116membrane hyperpolarization (GO:0060081)2.60567317
117plasma membrane repair (GO:0001778)2.60555195
118response to auditory stimulus (GO:0010996)2.60149722
119startle response (GO:0001964)2.59245269
120neuromuscular process controlling posture (GO:0050884)2.57518356
121neuronal ion channel clustering (GO:0045161)2.57407438
122regulation of neurotransmitter levels (GO:0001505)2.55987449
123positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.55728779
124suckling behavior (GO:0001967)2.55692432
125nucleobase catabolic process (GO:0046113)2.55530022
126potassium ion homeostasis (GO:0055075)2.54975323
127prepulse inhibition (GO:0060134)2.54721118
128long-term synaptic potentiation (GO:0060291)2.54697431
129vesicle transport along microtubule (GO:0047496)2.53101474
130acidic amino acid transport (GO:0015800)2.52943035
131neuron projection extension (GO:1990138)2.52833463
132central nervous system neuron axonogenesis (GO:0021955)2.51568222
133regulation of dendritic spine development (GO:0060998)2.49773464
134apical protein localization (GO:0045176)2.49302583
135positive regulation of dendrite development (GO:1900006)2.48540066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.06664041
2GBX2_23144817_ChIP-Seq_PC3_Human2.65664251
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.60563874
4DROSHA_22980978_ChIP-Seq_HELA_Human2.53088576
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.50822769
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.44652138
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41781576
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41781576
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.35909332
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.21315464
11* RARB_27405468_Chip-Seq_BRAIN_Mouse2.18797559
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18565911
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.13375155
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10516481
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05401753
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03762541
17REST_21632747_ChIP-Seq_MESCs_Mouse2.03114689
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02966562
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.96176929
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.96017935
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95524897
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95122218
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.86668915
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.84355838
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72792035
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72232036
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69070867
28AR_21572438_ChIP-Seq_LNCaP_Human1.60615758
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58146249
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.57278715
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54778681
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.53419534
33* KDM2B_26808549_Chip-Seq_K562_Human1.52694692
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.51011451
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50697965
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50505149
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49240678
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.48923177
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.48146716
40TAF15_26573619_Chip-Seq_HEK293_Human1.46535229
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.44942726
42WT1_25993318_ChIP-Seq_PODOCYTE_Human1.43994099
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.42689054
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41970517
45* AR_19668381_ChIP-Seq_PC3_Human1.37337027
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.35482567
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35331589
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34313256
49* TP53_16413492_ChIP-PET_HCT116_Human1.34012699
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34008508
51TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33319961
52* AHR_22903824_ChIP-Seq_MCF-7_Human1.32625114
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.32594796
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30084766
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30050385
56* ARNT_22903824_ChIP-Seq_MCF-7_Human1.28875806
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27675184
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26731800
59ZNF274_21170338_ChIP-Seq_K562_Hela1.26540111
60STAT3_23295773_ChIP-Seq_U87_Human1.25740640
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25587698
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25322813
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.22993531
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22747643
65* EP300_21415370_ChIP-Seq_HL-1_Mouse1.22742967
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21753015
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21753015
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21306020
69RNF2_27304074_Chip-Seq_NSC_Mouse1.21131062
70RING1B_27294783_Chip-Seq_NPCs_Mouse1.21090029
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20677315
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20588072
73TP53_18474530_ChIP-ChIP_U2OS_Human1.19600415
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.18794748
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.18448224
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18085743
77* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17713017
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17318473
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14744467
80LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13844185
81* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13565844
82CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13497693
83* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12149921
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.12065307
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09974852
86* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09594154
87OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08611248
88AR_25329375_ChIP-Seq_VCAP_Human1.07371550
89* TCF4_23295773_ChIP-Seq_U87_Human1.06469342
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06450041
91* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06439025
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.06233695
93SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06148430
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06138580
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05960012
96* SOX9_26525672_Chip-Seq_HEART_Mouse1.05407127
97SMAD4_21741376_ChIP-Seq_HESCs_Human1.05035031
98RXR_22108803_ChIP-Seq_LS180_Human1.04849346
99ISL1_27105846_Chip-Seq_CPCs_Mouse1.04532165
100RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04434606
101KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03849075
102SMAD3_21741376_ChIP-Seq_HESCs_Human1.02178835
103ESR1_20079471_ChIP-ChIP_T-47D_Human1.01366370
104* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00334262
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00049530
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98615249
107DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97535158
108* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96409138
109SMAD3_21741376_ChIP-Seq_ESCs_Human0.96052999
110P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95804531
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94250866
112ESR2_21235772_ChIP-Seq_MCF-7_Human0.92760197
113* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92506137
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92085995
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92085995
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91226456
117TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90869954
118* P300_19829295_ChIP-Seq_ESCs_Human0.89541818
119* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89477307
120* KDM2B_26808549_Chip-Seq_JURKAT_Human0.88304881
121TET1_21490601_ChIP-Seq_MESCs_Mouse0.87915567
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87770577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.37187842
2MP0003635_abnormal_synaptic_transmissio3.66898971
3MP0004270_analgesia3.42353590
4MP0009046_muscle_twitch2.97094014
5MP0003880_abnormal_central_pattern2.90604769
6MP0002063_abnormal_learning/memory/cond2.83841383
7MP0009745_abnormal_behavioral_response2.64840802
8MP0002064_seizures2.49362645
9MP0009780_abnormal_chondrocyte_physiolo2.41328357
10MP0000569_abnormal_digit_pigmentation2.35742214
11MP0002572_abnormal_emotion/affect_behav2.30142932
12MP0002734_abnormal_mechanical_nocicepti2.28879637
13MP0004858_abnormal_nervous_system2.22036782
14MP0001486_abnormal_startle_reflex2.15760731
15MP0005423_abnormal_somatic_nervous2.14763177
16MP0002272_abnormal_nervous_system2.12586944
17MP0008569_lethality_at_weaning2.04290734
18MP0000778_abnormal_nervous_system2.03485248
19MP0001968_abnormal_touch/_nociception2.02233189
20MP0004885_abnormal_endolymph1.92984256
21MP0000751_myopathy1.78000173
22MP0002184_abnormal_innervation1.77436284
23MP0002067_abnormal_sensory_capabilities1.76731682
24MP0001440_abnormal_grooming_behavior1.76259237
25MP0001501_abnormal_sleep_pattern1.70797896
26MP0000920_abnormal_myelination1.64137745
27MP0004811_abnormal_neuron_physiology1.62036155
28MP0002735_abnormal_chemical_nociception1.61978828
29MP0002909_abnormal_adrenal_gland1.58300825
30MP0004145_abnormal_muscle_electrophysio1.52451910
31MP0002557_abnormal_social/conspecific_i1.52058948
32MP0000955_abnormal_spinal_cord1.51145200
33MP0003787_abnormal_imprinting1.51042269
34MP0002736_abnormal_nociception_after1.48374553
35MP0002733_abnormal_thermal_nociception1.48028507
36MP0005623_abnormal_meninges_morphology1.45130001
37MP0004215_abnormal_myocardial_fiber1.43196312
38MP0001970_abnormal_pain_threshold1.42172547
39MP0000579_abnormal_nail_morphology1.40997940
40MP0003329_amyloid_beta_deposits1.39839074
41MP0005386_behavior/neurological_phenoty1.39797571
42MP0004924_abnormal_behavior1.39797571
43MP0005409_darkened_coat_color1.38890840
44MP0002822_catalepsy1.37455870
45MP0002882_abnormal_neuron_morphology1.31648612
46MP0001299_abnormal_eye_distance/1.30045179
47MP0005187_abnormal_penis_morphology1.26303981
48MP0002152_abnormal_brain_morphology1.25031285
49MP0002066_abnormal_motor_capabilities/c1.24630250
50MP0010234_abnormal_vibrissa_follicle1.22343494
51MP0003283_abnormal_digestive_organ1.21750593
52MP0000566_synostosis1.20956685
53MP0003137_abnormal_impulse_conducting1.20509765
54MP0008438_abnormal_cutaneous_collagen1.19508081
55MP0001958_emphysema1.18841829
56MP0008961_abnormal_basal_metabolism1.18254207
57MP0004233_abnormal_muscle_weight1.17506872
58MP0004085_abnormal_heartbeat1.13937953
59MP0003633_abnormal_nervous_system1.13875945
60MP0003879_abnormal_hair_cell1.10885939
61MP0003632_abnormal_nervous_system1.10823935
62MP0003045_fibrosis1.07717534
63MP0003631_nervous_system_phenotype1.07111305
64MP0004484_altered_response_of1.06471165
65MP0002837_dystrophic_cardiac_calcinosis1.05035576
66MP0001177_atelectasis1.04795090
67MP0000534_abnormal_ureter_morphology1.02610872
68MP0003705_abnormal_hypodermis_morpholog1.02412532
69MP0005646_abnormal_pituitary_gland1.02025009
70MP0005248_abnormal_Harderian_gland1.01809166
71MP0010368_abnormal_lymphatic_system0.99278924
72MP0005503_abnormal_tendon_morphology0.97912145
73MP0003861_abnormal_nervous_system0.95674979
74MP0001984_abnormal_olfaction0.95384852
75MP0003385_abnormal_body_wall0.94382148
76MP0004272_abnormal_basement_membrane0.92717757
77MP0000428_abnormal_craniofacial_morphol0.91734928
78MP0001502_abnormal_circadian_rhythm0.89811397
79MP0002234_abnormal_pharynx_morphology0.88742347
80MP0003122_maternal_imprinting0.88246085
81MP0001879_abnormal_lymphatic_vessel0.88168660
82MP0002089_abnormal_postnatal_growth/wei0.83730706
83MP0003690_abnormal_glial_cell0.82785006
84MP0005645_abnormal_hypothalamus_physiol0.81391310
85MP0003634_abnormal_glial_cell0.81346682
86MP0005257_abnormal_intraocular_pressure0.80669004
87MP0004084_abnormal_cardiac_muscle0.79933827
88MP0001529_abnormal_vocalization0.79666108
89MP0005275_abnormal_skin_tensile0.78924216
90MP0003091_abnormal_cell_migration0.78342986
91MP0001963_abnormal_hearing_physiology0.77870016
92MP0005171_absent_coat_pigmentation0.77134396
93MP0006276_abnormal_autonomic_nervous0.76049384
94MP0004087_abnormal_muscle_fiber0.75945991
95MP0002069_abnormal_eating/drinking_beha0.75166828
96MP0004130_abnormal_muscle_cell0.74165334
97MP0005167_abnormal_blood-brain_barrier0.74005580
98MP0002081_perinatal_lethality0.73527649
99MP0001485_abnormal_pinna_reflex0.72138024
100MP0000537_abnormal_urethra_morphology0.72120175
101MP0002896_abnormal_bone_mineralization0.71017204
102MP0000747_muscle_weakness0.69006132
103MP0001943_abnormal_respiration0.68316870
104MP0005620_abnormal_muscle_contractility0.68294998
105MP0005394_taste/olfaction_phenotype0.68081302
106MP0005499_abnormal_olfactory_system0.68081302
107MP0004742_abnormal_vestibular_system0.67911306
108MP0000762_abnormal_tongue_morphology0.67905369
109MP0002229_neurodegeneration0.67479223
110MP0006138_congestive_heart_failure0.67017386
111MP0010769_abnormal_survival0.66920191
112MP0000026_abnormal_inner_ear0.66865382
113MP0003121_genomic_imprinting0.66790913
114MP0003935_abnormal_craniofacial_develop0.66231207
115MP0000631_abnormal_neuroendocrine_gland0.66099463
116MP0004510_myositis0.65148039
117MP0004142_abnormal_muscle_tone0.64846519
118MP0002082_postnatal_lethality0.64213841
119MP0010770_preweaning_lethality0.64213841
120MP0000003_abnormal_adipose_tissue0.63280992
121MP0010768_mortality/aging0.62068856
122MP0002653_abnormal_ependyma_morphology0.61679312
123MP0003123_paternal_imprinting0.60077467
124MP0010386_abnormal_urinary_bladder0.59772080
125MP0008874_decreased_physiological_sensi0.58629446
126MP0000013_abnormal_adipose_tissue0.58616864
127MP0002752_abnormal_somatic_nervous0.58609572
128MP0002972_abnormal_cardiac_muscle0.58423416

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.95168614
2Action tremor (HP:0002345)4.42156360
3Focal seizures (HP:0007359)4.38142923
4Myokymia (HP:0002411)4.30220735
5Progressive cerebellar ataxia (HP:0002073)4.10338955
6Genetic anticipation (HP:0003743)3.68006260
7Visual hallucinations (HP:0002367)3.56944338
8Neurofibrillary tangles (HP:0002185)3.43482374
9Gaze-evoked nystagmus (HP:0000640)3.22281250
10Dysmetric saccades (HP:0000641)3.19106092
11Epileptic encephalopathy (HP:0200134)3.08490587
12Abnormality of the lower motor neuron (HP:0002366)3.07012854
13Dysdiadochokinesis (HP:0002075)3.03629799
14Febrile seizures (HP:0002373)2.97826259
15Atonic seizures (HP:0010819)2.91079540
16Broad-based gait (HP:0002136)2.85339978
17Poor eye contact (HP:0000817)2.78482776
18Hemiplegia (HP:0002301)2.75571873
19Impaired social interactions (HP:0000735)2.72040991
20Abnormal social behavior (HP:0012433)2.72040991
21Urinary bladder sphincter dysfunction (HP:0002839)2.71197568
22Absence seizures (HP:0002121)2.66460991
23Impaired vibration sensation in the lower limbs (HP:0002166)2.60444989
24Generalized tonic-clonic seizures (HP:0002069)2.57613830
25Impaired smooth pursuit (HP:0007772)2.56156097
26Termporal pattern (HP:0011008)2.56080217
27Insidious onset (HP:0003587)2.56080217
28Supranuclear gaze palsy (HP:0000605)2.55482956
29Shallow orbits (HP:0000586)2.53573070
30Dysmetria (HP:0001310)2.50042844
31Scanning speech (HP:0002168)2.48464959
32Hemiparesis (HP:0001269)2.42218550
33Abnormality of ocular smooth pursuit (HP:0000617)2.39552275
34Drooling (HP:0002307)2.38568785
35Excessive salivation (HP:0003781)2.38568785
36Bundle branch block (HP:0011710)2.38380969
37Dialeptic seizures (HP:0011146)2.37343494
38Atrophic scars (HP:0001075)2.36772860
39Neonatal short-limb short stature (HP:0008921)2.36582615
40Depression (HP:0000716)2.36087766
41Ankle clonus (HP:0011448)2.35739362
42Insomnia (HP:0100785)2.35322910
43Ventricular fibrillation (HP:0001663)2.34006983
44Postural instability (HP:0002172)2.31799603
45Intention tremor (HP:0002080)2.31600523
46Degeneration of the lateral corticospinal tracts (HP:0002314)2.31443364
47Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.31443364
48Pointed chin (HP:0000307)2.30430608
49Vascular tortuosity (HP:0004948)2.29685553
50Arterial tortuosity (HP:0005116)2.29529369
51Hammertoe (HP:0001765)2.28600232
52Truncal ataxia (HP:0002078)2.27964125
53Aplasia involving bones of the extremities (HP:0009825)2.26041266
54Aplasia involving bones of the upper limbs (HP:0009823)2.26041266
55Aplasia of the phalanges of the hand (HP:0009802)2.26041266
56Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.25735949
57Urinary urgency (HP:0000012)2.25387068
58Mutism (HP:0002300)2.21387576
59Macroorchidism (HP:0000053)2.17496483
60Abnormality of the corticospinal tract (HP:0002492)2.16863965
61Mild short stature (HP:0003502)2.16171393
62Overgrowth (HP:0001548)2.14942708
63Megalencephaly (HP:0001355)2.13842861
64Vertebral arch anomaly (HP:0008438)2.11539074
65Papillary thyroid carcinoma (HP:0002895)2.10736813
66Hyperacusis (HP:0010780)2.06784554
67Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.06526734
68Cutaneous finger syndactyly (HP:0010554)2.05738760
69Obstructive sleep apnea (HP:0002870)2.05296848
70Elfin facies (HP:0004428)2.04532677
71Broad metatarsal (HP:0001783)2.04416702
72Aqueductal stenosis (HP:0002410)2.03404711
73Turricephaly (HP:0000262)2.03324849
74Protrusio acetabuli (HP:0003179)2.00895813
75Abnormality of binocular vision (HP:0011514)1.99905128
76Diplopia (HP:0000651)1.99905128
77Sudden death (HP:0001699)1.98263701
78Coronal craniosynostosis (HP:0004440)1.92185602
79Alacrima (HP:0000522)1.89340881
80Syncope (HP:0001279)1.89017875
81Stereotypic behavior (HP:0000733)1.88823694
82Lower limb amyotrophy (HP:0007210)1.88402412
83Decreased motor nerve conduction velocity (HP:0003431)1.87940216
84Hyperventilation (HP:0002883)1.86589100
85Spastic gait (HP:0002064)1.84858709
86Lower limb asymmetry (HP:0100559)1.82967864
87Prolonged QT interval (HP:0001657)1.82925350
88Anxiety (HP:0000739)1.82735653
89Abnormality of the ischium (HP:0003174)1.82708813
90Amblyopia (HP:0000646)1.82661471
91Annular pancreas (HP:0001734)1.81812754
92Enlarged penis (HP:0000040)1.81595856
93Epileptiform EEG discharges (HP:0011182)1.79799718
94Wide anterior fontanel (HP:0000260)1.79157226
95Lower limb muscle weakness (HP:0007340)1.78114927
96Atrial fibrillation (HP:0005110)1.77203614
97Heterotopia (HP:0002282)1.76873409
98Amyotrophic lateral sclerosis (HP:0007354)1.76836867
99Absent speech (HP:0001344)1.76284808
100EEG with generalized epileptiform discharges (HP:0011198)1.76269533
101Primary atrial arrhythmia (HP:0001692)1.76099649
102Split foot (HP:0001839)1.76080772
103Thickened helices (HP:0000391)1.75577484
104Obsessive-compulsive behavior (HP:0000722)1.75348742
105Cutaneous syndactyly (HP:0012725)1.75107240
106Cerebral inclusion bodies (HP:0100314)1.75069071
107Status epilepticus (HP:0002133)1.74302903
108Impaired vibratory sensation (HP:0002495)1.74081982
109Bowel diverticulosis (HP:0005222)1.73626040
110Bronchomalacia (HP:0002780)1.73265923
111Upper limb amyotrophy (HP:0009129)1.72251823
112Distal upper limb amyotrophy (HP:0007149)1.72251823
113Bladder diverticulum (HP:0000015)1.72234254
114Abnormal eating behavior (HP:0100738)1.71926015
115Hypsarrhythmia (HP:0002521)1.71916712
116Renovascular hypertension (HP:0100817)1.71578863
117Hypoplasia of the iris (HP:0007676)1.71180823
118Postural tremor (HP:0002174)1.70487613
119Agitation (HP:0000713)1.70117954
120Peripheral hypomyelination (HP:0007182)1.69888994
121Decreased lacrimation (HP:0000633)1.68646060
122Torticollis (HP:0000473)1.67825731
123Pheochromocytoma (HP:0002666)1.66676522
124Gait ataxia (HP:0002066)1.66233424
125Overriding aorta (HP:0002623)1.64896232
126Papilledema (HP:0001085)1.64298033
127Abnormal EKG (HP:0003115)1.63705803
128Difficulty running (HP:0009046)1.63522959
129Neoplasm of the heart (HP:0100544)1.63228427
130Bradycardia (HP:0001662)1.62914735
131Tetraplegia (HP:0002445)1.62597330
132Limited hip movement (HP:0008800)1.61426815
133Inappropriate behavior (HP:0000719)1.59310997
134Astrocytoma (HP:0009592)1.59192554
135Abnormality of the astrocytes (HP:0100707)1.59192554
136Hypoplasia of the corpus callosum (HP:0002079)1.59144553
137Onion bulb formation (HP:0003383)1.58919702
138Bradykinesia (HP:0002067)1.58709995
139Mitral regurgitation (HP:0001653)1.57593020
140Cerebral aneurysm (HP:0004944)1.56411855
141Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.56147486
142Short 4th metacarpal (HP:0010044)1.56147486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.91563410
2NTRK33.84898464
3MAP3K93.09265953
4EPHA42.95145998
5MARK12.79338004
6MAP3K42.72611652
7PAK62.30485988
8PRKD32.17172906
9NTRK22.12347595
10DAPK22.05979156
11CAMKK12.02211307
12MINK12.01623881
13RIPK11.85571692
14EPHB21.84821778
15MAP2K41.76728211
16STK381.74031399
17MAP2K71.65838665
18KSR21.62162651
19LATS21.61956405
20CAMK1G1.61698146
21SIK21.61489854
22NTRK11.49193625
23TYRO31.46037471
24KSR11.40098000
25DMPK1.34410409
26LATS11.31581866
27LMTK21.31418432
28MAPK131.28655747
29PHKG21.28252800
30PHKG11.28252800
31CDK51.27158913
32PDGFRA1.25638821
33PNCK1.21045331
34CAMKK21.19769632
35TAOK11.15718919
36WNK11.15158451
37SGK31.14821014
38ALK1.12902798
39MET1.12202975
40DDR21.11173004
41RET1.10732059
42TRIB31.10406916
43CAMK1D1.08863182
44CDK121.06251566
45CDC42BPA1.05357022
46SGK21.05305386
47PAK31.04873705
48SGK4941.02156718
49SGK2231.02156718
50STK110.95817259
51PKN10.95487312
52PRKCH0.94013294
53MARK20.93431190
54TNIK0.89184231
55MAP3K60.88791306
56SIK10.88643830
57PLK20.88326791
58CAMK10.86011963
59BCR0.85591481
60PRKCG0.83122562
61NEK10.82921718
62UHMK10.82390432
63MOS0.81666312
64SGK10.80907503
65PRPF4B0.80528823
66DAPK10.79762860
67MAP3K20.79217149
68STK390.75579556
69AKT30.75461805
70CAMK2G0.75324355
71CAMK40.74353640
72INSRR0.74181424
73MAP3K70.72821926
74CAMK2A0.72184137
75CDK150.70608653
76NEK60.68797919
77PTK2B0.68157606
78FER0.68147929
79CDK180.67993342
80PTK20.67574246
81PAK20.66302056
82RPS6KA30.65263564
83GRK50.65140280
84BMX0.64285098
85DYRK1A0.63424670
86CDK140.63154654
87ICK0.60995370
88FGFR20.60107385
89CDK11A0.58174107
90MAPK100.57964343
91PRKAA10.56396565
92CSNK1G20.54235141
93CAMK2B0.53950392
94PDPK10.52820181
95PINK10.52816032
96MTOR0.52252595
97ERBB20.51679880
98RIPK40.51676072
99CAMK2D0.51129798
100PDGFRB0.49355237
101PTK60.49124889
102ERBB30.48968667
103BRD40.48469394
104EPHA30.48217211
105PRKCZ0.48046984
106ROCK10.46934115
107PDK10.46852010
108CSNK1E0.45312163
109PKN20.45062588
110ROCK20.43938861
111PRKCE0.43127555
112MAPK80.42765829
113EEF2K0.42027587
114GSK3B0.41996783
115PRKD10.41796613
116YES10.41289393
117PRKG10.38918246
118DYRK20.37633449
119CSNK1D0.35419422
120CCNB10.35082667
121RAF10.33762454

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.98936397
2Long-term potentiation_Homo sapiens_hsa047202.40075568
3Circadian entrainment_Homo sapiens_hsa047132.36434004
4Glutamatergic synapse_Homo sapiens_hsa047242.34641179
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15482254
6GABAergic synapse_Homo sapiens_hsa047272.13764368
7Synaptic vesicle cycle_Homo sapiens_hsa047212.10242851
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00133105
9Amphetamine addiction_Homo sapiens_hsa050311.94945311
10Salivary secretion_Homo sapiens_hsa049701.93326931
11Olfactory transduction_Homo sapiens_hsa047401.93120245
12Morphine addiction_Homo sapiens_hsa050321.88925702
13Insulin secretion_Homo sapiens_hsa049111.82101940
14Dopaminergic synapse_Homo sapiens_hsa047281.77102260
15Nitrogen metabolism_Homo sapiens_hsa009101.76808298
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76218516
17Gastric acid secretion_Homo sapiens_hsa049711.73758092
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70181811
19Long-term depression_Homo sapiens_hsa047301.65627518
20Cholinergic synapse_Homo sapiens_hsa047251.61957280
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.57025643
22Taste transduction_Homo sapiens_hsa047421.55427952
23Type II diabetes mellitus_Homo sapiens_hsa049301.54996238
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53014216
25Oxytocin signaling pathway_Homo sapiens_hsa049211.50218454
26GnRH signaling pathway_Homo sapiens_hsa049121.49186319
27Renin secretion_Homo sapiens_hsa049241.37475578
28Gap junction_Homo sapiens_hsa045401.32560080
29Calcium signaling pathway_Homo sapiens_hsa040201.32514242
30Dilated cardiomyopathy_Homo sapiens_hsa054141.30265714
31cAMP signaling pathway_Homo sapiens_hsa040241.30220207
32Estrogen signaling pathway_Homo sapiens_hsa049151.28638402
33Glioma_Homo sapiens_hsa052141.28459162
34Cocaine addiction_Homo sapiens_hsa050301.28176028
35ECM-receptor interaction_Homo sapiens_hsa045121.27705191
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26526719
37Dorso-ventral axis formation_Homo sapiens_hsa043201.22827507
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21760386
39Axon guidance_Homo sapiens_hsa043601.19073402
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18405820
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15397146
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13799977
43Serotonergic synapse_Homo sapiens_hsa047261.12423829
44ErbB signaling pathway_Homo sapiens_hsa040121.11731302
45Melanogenesis_Homo sapiens_hsa049161.11509942
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08089847
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02283540
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00932927
49Pancreatic secretion_Homo sapiens_hsa049720.96041993
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.95228500
51mTOR signaling pathway_Homo sapiens_hsa041500.93449912
52Prion diseases_Homo sapiens_hsa050200.92917545
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91183659
54Thyroid hormone synthesis_Homo sapiens_hsa049180.90002104
55Bile secretion_Homo sapiens_hsa049760.89600638
56Endometrial cancer_Homo sapiens_hsa052130.89576870
57Oocyte meiosis_Homo sapiens_hsa041140.86041781
58Choline metabolism in cancer_Homo sapiens_hsa052310.86024878
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.85374910
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81635728
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81318266
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.78886312
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74987762
64MAPK signaling pathway_Homo sapiens_hsa040100.74504620
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73194863
66Rap1 signaling pathway_Homo sapiens_hsa040150.72789625
67Glucagon signaling pathway_Homo sapiens_hsa049220.72279748
68Inositol phosphate metabolism_Homo sapiens_hsa005620.72262197
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72098978
70Wnt signaling pathway_Homo sapiens_hsa043100.71283373
71VEGF signaling pathway_Homo sapiens_hsa043700.70522362
72Protein digestion and absorption_Homo sapiens_hsa049740.68577666
73MicroRNAs in cancer_Homo sapiens_hsa052060.68261177
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67555063
75Tight junction_Homo sapiens_hsa045300.66171336
76Non-small cell lung cancer_Homo sapiens_hsa052230.65955290
77Insulin signaling pathway_Homo sapiens_hsa049100.63028249
78Renal cell carcinoma_Homo sapiens_hsa052110.62392248
79Hippo signaling pathway_Homo sapiens_hsa043900.62377702
80Ovarian steroidogenesis_Homo sapiens_hsa049130.62305740
81Proteoglycans in cancer_Homo sapiens_hsa052050.62119412
82Circadian rhythm_Homo sapiens_hsa047100.59785492
83Adherens junction_Homo sapiens_hsa045200.59611128
84Fatty acid biosynthesis_Homo sapiens_hsa000610.59365035
85Cardiac muscle contraction_Homo sapiens_hsa042600.59259862
86Focal adhesion_Homo sapiens_hsa045100.59027252
87Chronic myeloid leukemia_Homo sapiens_hsa052200.55912851
88Melanoma_Homo sapiens_hsa052180.55841342
89Ras signaling pathway_Homo sapiens_hsa040140.55242697
90Hedgehog signaling pathway_Homo sapiens_hsa043400.54630500
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53364659
92Prolactin signaling pathway_Homo sapiens_hsa049170.52990955
93Colorectal cancer_Homo sapiens_hsa052100.52556287
94AMPK signaling pathway_Homo sapiens_hsa041520.52125599
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51892692
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.50622880
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49261406
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49201387
99Notch signaling pathway_Homo sapiens_hsa043300.48551094
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48457414
101Lysine degradation_Homo sapiens_hsa003100.47650672
102Insulin resistance_Homo sapiens_hsa049310.46929409
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.46915221
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45968263
105Arginine biosynthesis_Homo sapiens_hsa002200.45877913
106Basal cell carcinoma_Homo sapiens_hsa052170.44306960
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44117622
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43353372
109Endocytosis_Homo sapiens_hsa041440.41144559
110Amoebiasis_Homo sapiens_hsa051460.41092768

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