ARHGAP22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)6.38273121
2modulation by symbiont of host immune response (GO:0052553)5.68040679
3positive regulation by symbiont of host defense response (GO:0052509)5.68040679
4modulation by symbiont of host defense response (GO:0052031)5.68040679
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.68040679
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.68040679
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.68040679
8natural killer cell mediated cytotoxicity (GO:0042267)5.32729248
9natural killer cell mediated immunity (GO:0002228)5.32729248
10response to muramyl dipeptide (GO:0032495)4.93249566
11tryptophan catabolic process (GO:0006569)4.91071918
12indole-containing compound catabolic process (GO:0042436)4.91071918
13indolalkylamine catabolic process (GO:0046218)4.91071918
14regulation of interferon-beta biosynthetic process (GO:0045357)4.83478495
15macrophage activation involved in immune response (GO:0002281)4.63171930
16negative regulation of mast cell activation (GO:0033004)4.60437317
17neutrophil activation involved in immune response (GO:0002283)4.55079301
18kynurenine metabolic process (GO:0070189)4.51194771
19cell adhesion mediated by integrin (GO:0033627)4.41510162
20positive regulation of interferon-alpha production (GO:0032727)4.22696939
21microglial cell activation (GO:0001774)4.22410143
22positive regulation of antigen processing and presentation (GO:0002579)4.19168484
23behavioral response to nicotine (GO:0035095)4.14097437
24regulation of dendritic cell antigen processing and presentation (GO:0002604)4.13409531
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.10545373
26indolalkylamine metabolic process (GO:0006586)4.09149750
27regulation of interferon-alpha production (GO:0032647)3.98539598
28tryptophan metabolic process (GO:0006568)3.93748741
29virion attachment to host cell (GO:0019062)3.91349255
30adhesion of symbiont to host cell (GO:0044650)3.91349255
31regulation of integrin activation (GO:0033623)3.82141849
32response to peptidoglycan (GO:0032494)3.70069238
33I-kappaB phosphorylation (GO:0007252)3.69567773
34negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.65543783
35negative regulation of cell killing (GO:0031342)3.65543783
36negative regulation of macrophage differentiation (GO:0045650)3.65269806
37amine catabolic process (GO:0009310)3.60404976
38cellular biogenic amine catabolic process (GO:0042402)3.60404976
39response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.57752356
40response to host immune response (GO:0052572)3.57752356
41negative regulation of nitric oxide biosynthetic process (GO:0045019)3.53150545
42regulation of antigen processing and presentation (GO:0002577)3.52564993
43regulation of interleukin-12 biosynthetic process (GO:0045075)3.47974365
44positive regulation of p38MAPK cascade (GO:1900745)3.45544777
45cellular response to exogenous dsRNA (GO:0071360)3.41058731
46positive regulation of gamma-delta T cell activation (GO:0046645)3.38961740
47cellular response to ATP (GO:0071318)3.37148454
48modulation by symbiont of host cellular process (GO:0044068)3.36718375
49negative regulation of granulocyte differentiation (GO:0030853)3.36193151
50endosome to melanosome transport (GO:0035646)3.32097910
51endosome to pigment granule transport (GO:0043485)3.32097910
52immunoglobulin mediated immune response (GO:0016064)3.31996259
53response to host defenses (GO:0052200)3.31375064
54response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.31375064
55response to host (GO:0075136)3.31375064
56NAD biosynthetic process (GO:0009435)3.29357379
57neutrophil activation (GO:0042119)3.26200892
58apoptotic cell clearance (GO:0043277)3.25107306
59negative regulation of leukocyte chemotaxis (GO:0002689)3.21482790
60granulocyte activation (GO:0036230)3.19397972
61detection of light stimulus involved in sensory perception (GO:0050962)3.15224567
62detection of light stimulus involved in visual perception (GO:0050908)3.15224567
63positive regulation of prostaglandin secretion (GO:0032308)3.12956615
64germinal center formation (GO:0002467)3.12356602
65positive regulation of mast cell degranulation (GO:0043306)3.11279360
66positive regulation of mast cell activation involved in immune response (GO:0033008)3.11279360
67positive regulation of interferon-beta production (GO:0032728)3.11132331
68leukocyte mediated cytotoxicity (GO:0001909)3.11116141
69ruffle organization (GO:0031529)3.07414780
70mature B cell differentiation (GO:0002335)3.06438175
71negative regulation of nitric-oxide synthase activity (GO:0051001)3.06041549
72macrophage activation (GO:0042116)3.04217521
73cortical actin cytoskeleton organization (GO:0030866)3.03470047
74wound healing, spreading of epidermal cells (GO:0035313)3.03153257
75positive regulation of protein oligomerization (GO:0032461)3.03059764
76positive regulation of cellular amide metabolic process (GO:0034250)3.00654543
77positive regulation of B cell differentiation (GO:0045579)2.98641072
78myeloid cell activation involved in immune response (GO:0002275)2.97987739
79lymphangiogenesis (GO:0001946)2.96333261
80substrate-dependent cell migration (GO:0006929)2.95719853
81adhesion of symbiont to host (GO:0044406)2.93477626
82positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.93412248
83fucose catabolic process (GO:0019317)2.91316507
84L-fucose metabolic process (GO:0042354)2.91316507
85L-fucose catabolic process (GO:0042355)2.91316507
86negative regulation of telomere maintenance (GO:0032205)2.87651709
87positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.87015595
88cytokine secretion (GO:0050663)2.86057608
89lymphocyte mediated immunity (GO:0002449)2.80904355
90pinocytosis (GO:0006907)2.80765302
91positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.80628204
92negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78680230
93neutrophil mediated immunity (GO:0002446)2.78328774
94glycerophospholipid catabolic process (GO:0046475)2.78115694
95indole-containing compound metabolic process (GO:0042430)2.77913237
96positive regulation of defense response to virus by host (GO:0002230)2.77627717
97dendritic cell differentiation (GO:0097028)2.75102274
98mature B cell differentiation involved in immune response (GO:0002313)2.72961389
99semaphorin-plexin signaling pathway (GO:0071526)2.72604193
100positive regulation of cell adhesion mediated by integrin (GO:0033630)2.71597306
101negative regulation of smooth muscle cell migration (GO:0014912)2.71050650
102negative regulation of interleukin-1 beta production (GO:0032691)2.71046914
103regulation of T-helper 1 cell differentiation (GO:0045625)2.70335544
104positive regulation of interleukin-12 production (GO:0032735)2.70196301
105regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.67382640
106positive regulation of T cell apoptotic process (GO:0070234)2.64879456
107positive regulation of mast cell activation (GO:0033005)2.64440530
108lytic vacuole organization (GO:0080171)2.64008911
109lysosome organization (GO:0007040)2.64008911
110membrane raft organization (GO:0031579)2.63916279
111cortical cytoskeleton organization (GO:0030865)2.63680304
112myeloid dendritic cell differentiation (GO:0043011)2.62729732
113regulation of early endosome to late endosome transport (GO:2000641)2.61884380
114positive regulation of leukocyte apoptotic process (GO:2000108)2.61297420
115positive regulation of heat generation (GO:0031652)2.60706039
116phosphatidylglycerol biosynthetic process (GO:0006655)2.60565704
117regulation of prostaglandin secretion (GO:0032306)2.59684032
118heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.58567076
119negative regulation of interleukin-6 production (GO:0032715)2.58122097
120positive regulation of smooth muscle cell migration (GO:0014911)2.57802629
121positive regulation of lymphocyte apoptotic process (GO:0070230)2.57774240
122B cell homeostasis (GO:0001782)2.57389125
123T cell mediated immunity (GO:0002456)2.56985719
124protein polyglutamylation (GO:0018095)2.56808164
125interferon-gamma-mediated signaling pathway (GO:0060333)2.56636697
126antigen processing and presentation of endogenous antigen (GO:0019883)2.56348592
127growth hormone receptor signaling pathway (GO:0060396)2.54662239
128positive regulation of fatty acid transport (GO:2000193)2.54321244
129NLS-bearing protein import into nucleus (GO:0006607)2.53316167
130platelet dense granule organization (GO:0060155)2.53055608
131low-density lipoprotein particle clearance (GO:0034383)2.51836554
132negative regulation of interleukin-12 production (GO:0032695)2.51189520
133protein localization to endosome (GO:0036010)2.51130503
134response to ATP (GO:0033198)2.50820346
135interferon-gamma secretion (GO:0072643)2.50716318
136regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.50691764
137regulation of interleukin-12 production (GO:0032655)2.50315573
138regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.50055233
139monocyte chemotaxis (GO:0002548)2.50040910
140adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.49598355
141regulation of necroptotic process (GO:0060544)2.49197493
142opioid receptor signaling pathway (GO:0038003)2.48768173
143regulation of mast cell activation (GO:0033003)2.48041837
144B cell mediated immunity (GO:0019724)2.46628212
145macroautophagy (GO:0016236)2.46493243
146negative regulation of lipid storage (GO:0010888)2.46438818
147myeloid cell homeostasis (GO:0002262)2.45624890
148aromatic amino acid family catabolic process (GO:0009074)2.45281734
149positive regulation of monocyte chemotaxis (GO:0090026)2.45086610
150regulation of cholesterol storage (GO:0010885)2.44736221
151respiratory burst (GO:0045730)2.43972047
152regulation of membrane protein ectodomain proteolysis (GO:0051043)2.43750916
153regulation of monocyte chemotaxis (GO:0090025)2.43559987
154regulation of B cell receptor signaling pathway (GO:0050855)2.43557810
155positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.42764562
156proteoglycan biosynthetic process (GO:0030166)2.42519807
157regulation of mononuclear cell migration (GO:0071675)2.41570660
158positive regulation of icosanoid secretion (GO:0032305)2.40924620
159G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.40051522
160purine deoxyribonucleotide catabolic process (GO:0009155)2.38318230
161positive regulation of natural killer cell differentiation (GO:0032825)2.38111033
162lipopolysaccharide biosynthetic process (GO:0009103)2.37690562
163neuronal action potential (GO:0019228)2.34151226
164cellular ketone body metabolic process (GO:0046950)2.33993135
165lipopolysaccharide metabolic process (GO:0008653)2.33428163
166negative regulation of systemic arterial blood pressure (GO:0003085)2.33240528
167DNA deamination (GO:0045006)2.33238478
168negative regulation of interleukin-1 production (GO:0032692)2.32691762
169sulfation (GO:0051923)2.32568709
170detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.31931940
171adenosine receptor signaling pathway (GO:0001973)2.31340678
172positive regulation of calcium-mediated signaling (GO:0050850)2.30477389
173ganglioside metabolic process (GO:0001573)2.29817019
174dermatan sulfate biosynthetic process (GO:0030208)2.29711254
175purinergic receptor signaling pathway (GO:0035587)2.29458322
176intracellular pH reduction (GO:0051452)2.29402630
177purinergic nucleotide receptor signaling pathway (GO:0035590)2.28912150
178blood vessel maturation (GO:0001955)2.28615272
179regulation of interleukin-8 secretion (GO:2000482)2.27499645
180fucose metabolic process (GO:0006004)2.27006348
181response to pheromone (GO:0019236)2.25726036
182sphingoid metabolic process (GO:0046519)2.25600182
183ubiquinone biosynthetic process (GO:0006744)2.25427060
184preassembly of GPI anchor in ER membrane (GO:0016254)2.25345249
185tooth mineralization (GO:0034505)2.24850531
186positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.24844964
187synaptic transmission, cholinergic (GO:0007271)2.24356645
188regulation of mast cell activation involved in immune response (GO:0033006)2.23930251
189negative regulation of reactive oxygen species metabolic process (GO:2000378)2.23239120
190dermatan sulfate metabolic process (GO:0030205)2.22813774
191nicotinamide nucleotide biosynthetic process (GO:0019359)2.22798937
192pyridine nucleotide biosynthetic process (GO:0019363)2.22798937
193positive regulation of natural killer cell activation (GO:0032816)2.22574100
194negative regulation of monooxygenase activity (GO:0032769)2.22221997
195endoderm formation (GO:0001706)2.22139927
196regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.20675970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.49329717
2* IRF8_21731497_ChIP-ChIP_J774_Mouse4.46460109
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.30317170
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.14538654
5ZNF274_21170338_ChIP-Seq_K562_Hela3.59307408
6* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.42900534
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.41754173
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.27330100
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.26321370
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.16435895
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.94233814
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.68554334
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.64013046
14EZH2_22144423_ChIP-Seq_EOC_Human2.58623461
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.55943416
16GBX2_23144817_ChIP-Seq_PC3_Human2.45568977
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.37001695
18VDR_21846776_ChIP-Seq_THP-1_Human2.35472322
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.32458189
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21647385
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20575415
22* ELK3_25401928_ChIP-Seq_HUVEC_Human2.15826133
23* SPI1_23127762_ChIP-Seq_K562_Human2.14895234
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12228958
25VDR_22108803_ChIP-Seq_LS180_Human2.07605510
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06844299
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.04472342
28PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.94648182
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.93411662
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91284078
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91087852
32VDR_24763502_ChIP-Seq_THP-1_Human1.90304321
33* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.87443213
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.86332836
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.86178454
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81269629
37* TCF7_22412390_ChIP-Seq_EML_Mouse1.76970845
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76098113
39MAF_26560356_Chip-Seq_TH1_Human1.75227110
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74844705
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.72473064
42NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.70791045
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69989431
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.69758114
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68555481
46KDM2B_26808549_Chip-Seq_DND41_Human1.68298525
47TFEB_21752829_ChIP-Seq_HELA_Human1.67588138
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65949627
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.64814250
50* SPI1_23547873_ChIP-Seq_NB4_Human1.64781134
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63845070
52VDR_24787735_ChIP-Seq_THP-1_Human1.62546219
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59715969
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58787857
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58438583
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57986873
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57279468
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56379330
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.54179457
60ESR1_21235772_ChIP-Seq_MCF-7_Human1.50889431
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.46526428
62STAT1_20625510_ChIP-Seq_HELA_Human1.46452477
63* PU_27001747_Chip-Seq_BMDM_Mouse1.45853249
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.44296743
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43632859
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.42001638
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41624446
68MYC_22102868_ChIP-Seq_BL_Human1.41083724
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.40600987
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39417441
71* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.38469509
72* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.38469509
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38298546
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37697197
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36804095
76EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.36523994
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35945739
78* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35262861
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35152219
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33962929
81IGF1R_20145208_ChIP-Seq_DFB_Human1.33677806
82JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32257893
83* DROSHA_22980978_ChIP-Seq_HELA_Human1.32056498
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31602879
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31544356
86TAF2_19829295_ChIP-Seq_ESCs_Human1.31424598
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.31170377
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30238619
89SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28037796
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26661504
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26479363
92SCL_19346495_ChIP-Seq_HPC-7_Human1.26347645
93MYB_26560356_Chip-Seq_TH1_Human1.25196908
94SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24836562
95STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24156231
96* GATA2_21666600_ChIP-Seq_HMVEC_Human1.23881437
97* RACK7_27058665_Chip-Seq_MCF-7_Human1.23633492
98P300_19829295_ChIP-Seq_ESCs_Human1.23200655
99ATF3_27146783_Chip-Seq_COLON_Human1.22850809
100TP53_16413492_ChIP-PET_HCT116_Human1.22790949
101GATA3_21878914_ChIP-Seq_MCF-7_Human1.21985339
102STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21802757
103SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20959737
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20529417
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20311614
106FOXO3_23340844_ChIP-Seq_DLD1_Human1.19487567
107CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18917650
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18798927
109SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18715485
110STAT3_23295773_ChIP-Seq_U87_Human1.17942745
111* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17327030
112UTX_26944678_Chip-Seq_JUKART_Human1.16140362
113EZH2_27294783_Chip-Seq_ESCs_Mouse1.15872199
114RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.15817127
115MYB_26560356_Chip-Seq_TH2_Human1.14949420
116ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14927133
117* BRD4_25478319_ChIP-Seq_HGPS_Human1.14246784
118MYC_19829295_ChIP-Seq_ESCs_Human1.14227723
119IRF1_19129219_ChIP-ChIP_H3396_Human1.13315779
120BCL6_27268052_Chip-Seq_Bcells_Human1.13303446
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13009009
122CLOCK_20551151_ChIP-Seq_293T_Human1.12033949
123JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11772926
124PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11667105
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11305911
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.10939728
127PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10868064
128MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10805847
129LXR_22292898_ChIP-Seq_THP-1_Human1.10658735
130ERA_21632823_ChIP-Seq_H3396_Human1.10485292
131BCAT_22108803_ChIP-Seq_LS180_Human1.10110360
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09830143
133RUNX_20019798_ChIP-Seq_JUKART_Human1.09393985
134NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09376740
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09358535
136CBP_20019798_ChIP-Seq_JUKART_Human1.09358535
137TP53_22573176_ChIP-Seq_HFKS_Human1.08507188
138* REST_21632747_ChIP-Seq_MESCs_Mouse1.08120034
139* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07495334
140NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06980964
141NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06980964
142SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06629010
143JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06421195
144ER_23166858_ChIP-Seq_MCF-7_Human1.06126549
145FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05769856
146SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05556877
147NANOG_19829295_ChIP-Seq_ESCs_Human1.05431812
148SOX2_19829295_ChIP-Seq_ESCs_Human1.05431812
149FOXH1_21741376_ChIP-Seq_ESCs_Human1.05340478
150SMAD4_21741376_ChIP-Seq_EPCs_Human1.04871464
151RAC3_21632823_ChIP-Seq_H3396_Human1.04141165
152* UBF1/2_26484160_Chip-Seq_HMECs_Human1.03917672
153CTCF_20526341_ChIP-Seq_ESCs_Human1.03056900
154* KDM2B_26808549_Chip-Seq_K562_Human1.02603725
155* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02411802
156HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02017245
157PRDM14_20953172_ChIP-Seq_ESCs_Human1.01200486
158NANOG_20526341_ChIP-Seq_ESCs_Human1.00774775
159MAF_26560356_Chip-Seq_TH2_Human1.00157652
160AR_25329375_ChIP-Seq_VCAP_Human0.99571663
161* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99297087
162SMAD_19615063_ChIP-ChIP_OVARY_Human0.98873347
163* TCF4_23295773_ChIP-Seq_U87_Human0.97925616
164TRIM28_21343339_ChIP-Seq_HEK293_Human0.97249713
165SMAD4_21799915_ChIP-Seq_A2780_Human0.97179035
166* FLI1_21867929_ChIP-Seq_TH2_Mouse0.97078589
167EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96008986
168KDM2B_26808549_Chip-Seq_JURKAT_Human0.95713822
169CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95252234
170ELF1_20517297_ChIP-Seq_JURKAT_Human0.94348749
171FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94043338
172FOXA1_25329375_ChIP-Seq_VCAP_Human0.94043338
173FOXH1_21741376_ChIP-Seq_EPCs_Human0.94028165
174MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.93492743
175AR_20517297_ChIP-Seq_VCAP_Human0.93198466
176* TP53_22127205_ChIP-Seq_IMR90_Human0.91073512
177CJUN_26792858_Chip-Seq_BT549_Human0.89943729
178NCOR1_26117541_ChIP-Seq_K562_Human0.88352750
179GATA3_27048872_Chip-Seq_THYMUS_Human0.87476688
180GATA6_25053715_ChIP-Seq_YYC3_Human0.87318658
181TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86502901
182SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86255818

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.63137156
2MP0005058_abnormal_lysosome_morphology3.69329866
3MP0004510_myositis3.34051909
4MP0003172_abnormal_lysosome_physiology3.31327829
5MP0001835_abnormal_antigen_presentation2.85134170
6MP0003195_calcinosis2.84146816
7MP0003950_abnormal_plasma_membrane2.72115976
8MP0003705_abnormal_hypodermis_morpholog2.70281559
9MP0002254_reproductive_system_inflammat2.68474415
10MP0010386_abnormal_urinary_bladder2.66423541
11MP0003303_peritoneal_inflammation2.65739571
12MP0009840_abnormal_foam_cell2.50677454
13MP0003436_decreased_susceptibility_to2.45170146
14MP0003566_abnormal_cell_adhesion2.42147177
15MP0009278_abnormal_bone_marrow2.36059372
16MP0003091_abnormal_cell_migration2.32448504
17MP0001542_abnormal_bone_strength2.29841485
18MP0002138_abnormal_hepatobiliary_system2.23142247
19MP0006054_spinal_hemorrhage2.21171791
20MP0003646_muscle_fatigue2.17051603
21MP0005076_abnormal_cell_differentiation2.16992304
22MP0000685_abnormal_immune_system2.13009259
23MP0002419_abnormal_innate_immunity2.11852382
24MP0009764_decreased_sensitivity_to2.09180106
25MP0001968_abnormal_touch/_nociception2.03456119
26MP0010352_gastrointestinal_tract_polyps2.03411757
27MP0003806_abnormal_nucleotide_metabolis2.01349984
28MP0005595_abnormal_vascular_smooth1.96429067
29MP0002166_altered_tumor_susceptibility1.93993806
30MP0005257_abnormal_intraocular_pressure1.92679626
31MP0003300_gastrointestinal_ulcer1.91958257
32MP0008438_abnormal_cutaneous_collagen1.90265392
33MP0006082_CNS_inflammation1.89228908
34MP0002452_abnormal_antigen_presenting1.87313500
35MP0004947_skin_inflammation1.84719059
36MP0010307_abnormal_tumor_latency1.83300412
37MP0001790_abnormal_immune_system1.81424272
38MP0005387_immune_system_phenotype1.81424272
39MP0005167_abnormal_blood-brain_barrier1.78852205
40MP0005000_abnormal_immune_tolerance1.77160201
41MP0009384_cardiac_valve_regurgitation1.72670832
42MP0001800_abnormal_humoral_immune1.71753820
43MP0005464_abnormal_platelet_physiology1.70625707
44MP0004858_abnormal_nervous_system1.68222295
45MP0001501_abnormal_sleep_pattern1.66601768
46MP0002837_dystrophic_cardiac_calcinosis1.65857684
47MP0009046_muscle_twitch1.64349130
48MP0002736_abnormal_nociception_after1.64225587
49MP0000733_abnormal_muscle_development1.62505366
50MP0002723_abnormal_immune_serum1.62209265
51MP0002877_abnormal_melanocyte_morpholog1.61942070
52MP0002733_abnormal_thermal_nociception1.60155293
53MP0002735_abnormal_chemical_nociception1.60112952
54MP0001958_emphysema1.59712441
55MP0001348_abnormal_lacrimal_gland1.59194359
56MP0005410_abnormal_fertilization1.53154862
57MP0004043_abnormal_pH_regulation1.52898278
58MP0005551_abnormal_eye_electrophysiolog1.52501589
59MP0003448_altered_tumor_morphology1.51975492
60MP0000230_abnormal_systemic_arterial1.48813252
61MP0001970_abnormal_pain_threshold1.48676668
62MP0005174_abnormal_tail_pigmentation1.48491335
63MP0001819_abnormal_immune_cell1.47939704
64MP0003183_abnormal_peptide_metabolism1.47020563
65MP0005397_hematopoietic_system_phenotyp1.46661756
66MP0001545_abnormal_hematopoietic_system1.46661756
67MP0001986_abnormal_taste_sensitivity1.43857455
68MP0002420_abnormal_adaptive_immunity1.43545507
69MP0002148_abnormal_hypersensitivity_rea1.41488660
70MP0005025_abnormal_response_to1.41453517
71MP0005023_abnormal_wound_healing1.41410021
72MP0001533_abnormal_skeleton_physiology1.39511477
73MP0000858_altered_metastatic_potential1.36820056
74MP0000604_amyloidosis1.36181413
75MP0002006_tumorigenesis1.33155540
76MP0003191_abnormal_cellular_cholesterol1.31832486
77MP0005623_abnormal_meninges_morphology1.27083067
78MP0003453_abnormal_keratinocyte_physiol1.26204894
79MP0000767_abnormal_smooth_muscle1.25430873
80MP0002405_respiratory_system_inflammati1.24983685
81MP0002998_abnormal_bone_remodeling1.22216725
82MP0003279_aneurysm1.21944158
83MP0000015_abnormal_ear_pigmentation1.21044504
84MP0000750_abnormal_muscle_regeneration1.20737305
85MP0000371_diluted_coat_color1.20481142
86MP0000538_abnormal_urinary_bladder1.20243868
87MP0009785_altered_susceptibility_to1.19736117
88MP0006276_abnormal_autonomic_nervous1.17792867
89MP0010368_abnormal_lymphatic_system1.17102769
90MP0002653_abnormal_ependyma_morphology1.16863659
91MP0004147_increased_porphyrin_level1.14950781
92MP0005671_abnormal_response_to1.14950437
93MP0000427_abnormal_hair_cycle1.13114029
94MP0003879_abnormal_hair_cell1.12021725
95MP0002102_abnormal_ear_morphology1.11765749
96MP0003633_abnormal_nervous_system1.11174398
97MP0004142_abnormal_muscle_tone1.10211901
98MP0002396_abnormal_hematopoietic_system1.07464723
99MP0003283_abnormal_digestive_organ1.07135849
100MP0005197_abnormal_uvea_morphology1.07078564
101MP0003045_fibrosis1.07029276
102MP0009745_abnormal_behavioral_response1.06377739
103MP0001873_stomach_inflammation1.06056494
104MP0001915_intracranial_hemorrhage1.05094777
105MP0005310_abnormal_salivary_gland1.03999871
106MP0004742_abnormal_vestibular_system1.03747272
107MP0000716_abnormal_immune_system1.03642187
108MP0002398_abnormal_bone_marrow1.00375594
109MP0005621_abnormal_cell_physiology0.99505382
110MP0004808_abnormal_hematopoietic_stem0.98575567
111MP0001845_abnormal_inflammatory_respons0.98198508
112MP0000689_abnormal_spleen_morphology0.98095567
113MP0002234_abnormal_pharynx_morphology0.95936612
114MP0001663_abnormal_digestive_system0.94390469
115MP0005083_abnormal_biliary_tract0.92286597
116MP0002572_abnormal_emotion/affect_behav0.91123105
117MP0001905_abnormal_dopamine_level0.89510967
118MP0004133_heterotaxia0.89244417
119MP0001243_abnormal_dermal_layer0.89227275
120MP0005503_abnormal_tendon_morphology0.89035941
121MP0002722_abnormal_immune_system0.89020170
122MP0002272_abnormal_nervous_system0.87476187
123MP0008469_abnormal_protein_level0.86759219
124MP0001853_heart_inflammation0.86120458
125MP0006072_abnormal_retinal_apoptosis0.84566874
126MP0003075_altered_response_to0.84490042
127MP0002064_seizures0.84344201
128MP0002429_abnormal_blood_cell0.84077033
129MP0002332_abnormal_exercise_endurance0.83689702
130MP0002229_neurodegeneration0.83415291
131MP0002933_joint_inflammation0.82830828
132MP0005165_increased_susceptibility_to0.79112581
133MP0000249_abnormal_blood_vessel0.78099111
134MP0008260_abnormal_autophagy0.78074126
135MP0003137_abnormal_impulse_conducting0.76312199
136MP0002067_abnormal_sensory_capabilities0.75937751
137MP0000343_altered_response_to0.75445725
138MP0000920_abnormal_myelination0.74430365
139MP0005390_skeleton_phenotype0.74356800
140MP0003631_nervous_system_phenotype0.73888711
141MP0005084_abnormal_gallbladder_morpholo0.73067224
142MP0005508_abnormal_skeleton_morphology0.72933166
143MP0005195_abnormal_posterior_eye0.72777537
144MP0002277_abnormal_respiratory_mucosa0.72299937
145MP0002168_other_aberrant_phenotype0.71074015
146MP0002928_abnormal_bile_duct0.70225381
147MP0009333_abnormal_splenocyte_physiolog0.69639268
148MP0010155_abnormal_intestine_physiology0.69148900
149MP0005253_abnormal_eye_physiology0.68838421
150MP0005384_cellular_phenotype0.68406947
151MP0008007_abnormal_cellular_replicative0.68227286
152MP0000627_abnormal_mammary_gland0.67544811
153MP0001963_abnormal_hearing_physiology0.67089532
154MP0005670_abnormal_white_adipose0.66508829
155MP0008875_abnormal_xenobiotic_pharmacok0.65672255
156MP0009250_abnormal_appendicular_skeleto0.64781682
157MP0004185_abnormal_adipocyte_glucose0.64254442
158MP0003828_pulmonary_edema0.62890919
159MP0000703_abnormal_thymus_morphology0.61483978
160MP0002060_abnormal_skin_morphology0.60616021
161MP0001851_eye_inflammation0.58534683

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.46966521
2Increased cerebral lipofuscin (HP:0011813)4.41170004
3Recurrent bacterial skin infections (HP:0005406)4.25842948
4Mesangial abnormality (HP:0001966)4.01395841
5Abnormality of liposaccharide metabolism (HP:0010968)3.90510907
6Abnormality of glycosphingolipid metabolism (HP:0004343)3.90510907
7Abnormality of glycolipid metabolism (HP:0010969)3.90510907
8Increased neuronal autofluorescent lipopigment (HP:0002074)3.61434482
9Cerebral aneurysm (HP:0004944)3.55179094
10Follicular hyperkeratosis (HP:0007502)3.45117736
11Distal lower limb amyotrophy (HP:0008944)3.44426151
12Osteolytic defects of the hand bones (HP:0009699)3.44322406
13Osteolytic defects of the phalanges of the hand (HP:0009771)3.44322406
14Hematochezia (HP:0002573)3.41929434
15Axonal loss (HP:0003447)3.38476819
16Type II lissencephaly (HP:0007260)3.32994729
17Systemic lupus erythematosus (HP:0002725)3.31924339
18Abnormality of midbrain morphology (HP:0002418)3.31346112
19Molar tooth sign on MRI (HP:0002419)3.31346112
20Vertebral compression fractures (HP:0002953)3.25792710
21Myocardial infarction (HP:0001658)3.21412073
22Eczematoid dermatitis (HP:0000976)3.17974420
23Upper limb amyotrophy (HP:0009129)3.10496811
24Distal upper limb amyotrophy (HP:0007149)3.10496811
25Abnormality of macrophages (HP:0004311)3.07874721
26Attenuation of retinal blood vessels (HP:0007843)3.06245889
27Pancreatic fibrosis (HP:0100732)3.05328375
28Genetic anticipation (HP:0003743)3.01647046
29Abolished electroretinogram (ERG) (HP:0000550)2.98183149
30Keratoconus (HP:0000563)2.97475295
31Increased corneal curvature (HP:0100692)2.97475295
32Elevated erythrocyte sedimentation rate (HP:0003565)2.96710091
33Pancreatic cysts (HP:0001737)2.93477401
34Congenital stationary night blindness (HP:0007642)2.92537724
35Vacuolated lymphocytes (HP:0001922)2.89130037
36Cerebellar dysplasia (HP:0007033)2.88585819
37Joint stiffness (HP:0001387)2.83136851
38Urethral obstruction (HP:0000796)2.78610575
39True hermaphroditism (HP:0010459)2.74282110
40Nephronophthisis (HP:0000090)2.72127052
41Thick nail (HP:0001805)2.68840663
42Pathologic fracture (HP:0002756)2.66131660
43Dysostosis multiplex (HP:0000943)2.65694919
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.65326606
45Lower limb amyotrophy (HP:0007210)2.64858744
46Premature rupture of membranes (HP:0001788)2.64836437
47Protruding tongue (HP:0010808)2.60304555
48Abnormal rod and cone electroretinograms (HP:0008323)2.60149965
49Hand muscle atrophy (HP:0009130)2.58816360
50Clumsiness (HP:0002312)2.56939069
51Frequent falls (HP:0002359)2.53542943
52Tetraparesis (HP:0002273)2.52665593
53Disinhibition (HP:0000734)2.50726190
54Mutism (HP:0002300)2.47881875
55Retinal atrophy (HP:0001105)2.43021563
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.40233428
57Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.39687095
58Difficulty climbing stairs (HP:0003551)2.39635420
59Gingivitis (HP:0000230)2.39533437
60Inability to walk (HP:0002540)2.39515990
61Glomerulonephritis (HP:0000099)2.38172632
62Recurrent fungal infections (HP:0002841)2.36306667
63Decreased central vision (HP:0007663)2.36224298
64Flat capital femoral epiphysis (HP:0003370)2.35094592
65Autoimmune thrombocytopenia (HP:0001973)2.34576160
66Absent frontal sinuses (HP:0002688)2.33970498
67Increased connective tissue (HP:0009025)2.30941758
68Myositis (HP:0100614)2.30408941
69Tubular atrophy (HP:0000092)2.30026717
70Increased density of long bones (HP:0006392)2.29758262
71Recurrent skin infections (HP:0001581)2.29026599
72Bone pain (HP:0002653)2.28648590
73Mediastinal lymphadenopathy (HP:0100721)2.28438157
74Short nail (HP:0001799)2.28335102
75Periodontitis (HP:0000704)2.27985738
76Global brain atrophy (HP:0002283)2.27289054
77Submucous cleft hard palate (HP:0000176)2.26829453
78Prostate neoplasm (HP:0100787)2.25848052
79Abnormality of polysaccharide metabolism (HP:0011012)2.24170902
80Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24170902
81Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24170902
82Loss of speech (HP:0002371)2.22256047
83Premature loss of primary teeth (HP:0006323)2.22073173
84Orchitis (HP:0100796)2.21727369
85Bulbous nose (HP:0000414)2.20956246
86Peritonitis (HP:0002586)2.17753827
87Urinary glycosaminoglycan excretion (HP:0003541)2.17071144
88Mucopolysacchariduria (HP:0008155)2.17071144
89Retinal dysplasia (HP:0007973)2.15303716
90Congenital hepatic fibrosis (HP:0002612)2.14889830
91Distal lower limb muscle weakness (HP:0009053)2.13641399
92Abnormality of the renal medulla (HP:0100957)2.12593228
93Polydipsia (HP:0001959)2.12054485
94Abnormal drinking behavior (HP:0030082)2.12054485
95Congenital sensorineural hearing impairment (HP:0008527)2.08592945
96Recurrent viral infections (HP:0004429)2.07817045
97Long toe (HP:0010511)2.07377463
98Basal ganglia calcification (HP:0002135)2.01552976
99Ovoid vertebral bodies (HP:0003300)2.01351084
100Nephritis (HP:0000123)2.00864458
101Leukocytosis (HP:0001974)1.98889414
102Aplasia/Hypoplasia of the tibia (HP:0005772)1.98787221
103Osteomyelitis (HP:0002754)1.98554901
104Mitral valve prolapse (HP:0001634)1.98538820
105Colitis (HP:0002583)1.97149233
106Macroglossia (HP:0000158)1.96765786
107Optic neuritis (HP:0100653)1.95081730
108Retrobulbar optic neuritis (HP:0100654)1.95081730
109Hyperventilation (HP:0002883)1.94420974
110Bony spicule pigmentary retinopathy (HP:0007737)1.93896642
111Recurrent gram-negative bacterial infections (HP:0005420)1.93298701
112Aortic valve stenosis (HP:0001650)1.92718256
113Achilles tendon contracture (HP:0001771)1.91957283
114Syringomyelia (HP:0003396)1.91890799
115Spinal cord lesions (HP:0100561)1.91890799
116Broad metatarsal (HP:0001783)1.91721065
117Spinal muscular atrophy (HP:0007269)1.91536439
118Arterial thrombosis (HP:0004420)1.90907450
119Progressive visual loss (HP:0000529)1.90669109
120Absent/shortened dynein arms (HP:0200106)1.90534838
121Dynein arm defect of respiratory motile cilia (HP:0012255)1.90534838
122Persistence of primary teeth (HP:0006335)1.89972768
123Aortic aneurysm (HP:0004942)1.89718891
124Cystic liver disease (HP:0006706)1.89011998
125Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.88629476
126Dilatation of the ascending aorta (HP:0005111)1.88507505
127Severe muscular hypotonia (HP:0006829)1.88397929
128Fatigue (HP:0012378)1.87425426
129Poor head control (HP:0002421)1.86721075
130Chronic hepatic failure (HP:0100626)1.85988667
131Upper motor neuron abnormality (HP:0002127)1.85700777
132Scapular winging (HP:0003691)1.85057598
133Opisthotonus (HP:0002179)1.85045892
134Concave nail (HP:0001598)1.84554810
135Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84254952
136Abnormality of alanine metabolism (HP:0010916)1.84254952
137Hyperalaninemia (HP:0003348)1.84254952
138Progressive cerebellar ataxia (HP:0002073)1.83773630
139Abnormality of the vertebral endplates (HP:0005106)1.83716392
140Amyloidosis (HP:0011034)1.83473923
141Progressive inability to walk (HP:0002505)1.83116379
142Spondylolisthesis (HP:0003302)1.81853123
143Congenital, generalized hypertrichosis (HP:0004540)1.81111975
144Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.80852103
145Bradycardia (HP:0001662)1.77513229
146Adactyly (HP:0009776)1.77456567
147Abnormality of the renal cortex (HP:0011035)1.76994291
148Cervical subluxation (HP:0003308)1.76895786
149Striae distensae (HP:0001065)1.76842017
150Disproportionate short-trunk short stature (HP:0003521)1.76422947
151Severe visual impairment (HP:0001141)1.75707401
152Abnormality of proline metabolism (HP:0010907)1.75581959
153Hydroxyprolinuria (HP:0003080)1.75581959
154Ulnar bowing (HP:0003031)1.75206169
155Tubulointerstitial fibrosis (HP:0005576)1.73767231
156Agnosia (HP:0010524)1.73708097
157Abnormality of transition element cation homeostasis (HP:0011030)1.71478967
158Vasculitis (HP:0002633)1.70489439
159Neuronal loss in central nervous system (HP:0002529)1.70386056
160Sclerocornea (HP:0000647)1.70331520
161Interstitial pulmonary disease (HP:0006530)1.70104900
162Ankle contracture (HP:0006466)1.67114295
163Protrusio acetabuli (HP:0003179)1.65436508
164Medial flaring of the eyebrow (HP:0010747)1.64686884
165Eosinophilia (HP:0001880)1.64112299
166Arterial tortuosity (HP:0005116)1.63846084
167Stomatitis (HP:0010280)1.63596956
168Aortic regurgitation (HP:0001659)1.63327022
169Redundant skin (HP:0001582)1.62903291
170Abnormality of the distal phalanges of the toes (HP:0010182)1.62694581
171Dysautonomia (HP:0002459)1.61672653
172Retinitis pigmentosa (HP:0000510)1.61487891
173Abnormality of dental color (HP:0011073)1.61161160
174Albinism (HP:0001022)1.60992727
175Prolonged neonatal jaundice (HP:0006579)1.60773161
176Irregular vertebral endplates (HP:0003301)1.59674141
177Abnormality of binocular vision (HP:0011514)1.59385560
178Diplopia (HP:0000651)1.59385560

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.51069062
2ADRBK23.99510238
3MAP3K143.97023761
4TYK23.26241388
5TTN3.21209533
6TBK13.15607858
7MAP3K132.74653884
8ACVR1B2.62858867
9GRK72.43705224
10CAMK1D2.42669599
11BMPR1B2.37676052
12IKBKB2.34129324
13RIPK42.33843889
14TRIB32.24830653
15KIT2.17630998
16TGFBR21.95071812
17MOS1.94391663
18JAK11.91481302
19PTK61.91295782
20LIMK11.90706367
21CHUK1.89783332
22CSF1R1.87729975
23TGFBR11.85277625
24WNK41.83794568
25BCKDK1.83440978
26ABL21.81439132
27PAK41.81394503
28IRAK31.81316107
29GRK11.79284307
30ADRBK11.78628251
31JAK31.76536766
32IKBKE1.74026179
33CAMK1G1.70953588
34INSRR1.58113660
35CAMKK21.55663243
36PKN21.52603525
37EPHB11.52201262
38MAP4K21.49957007
39RPS6KA41.49153069
40SIK21.48758272
41NUAK11.47831618
42CDK121.45835861
43SCYL21.45689872
44IRAK41.43441275
45EPHA21.42918907
46NEK91.32206768
47FGR1.28560095
48PTK21.26548604
49PINK11.23146963
50MAP2K31.20634791
51RIPK11.18842996
52LRRK21.16850010
53BMX1.16702118
54PRKD21.15159746
55TIE11.14667189
56MAP3K101.12673539
57TXK1.08650696
58STK101.05180594
59MATK1.04878698
60HCK1.03668892
61MAP3K30.99298448
62MUSK0.99003026
63CDK60.97727671
64MYLK0.96153343
65TRPM70.94645945
66WNK30.92925164
67ERN10.90760354
68ZAK0.90399194
69PIM20.88870767
70MTOR0.86947449
71KDR0.86711226
72ZAP700.86008437
73ICK0.85251594
74PAK20.84509726
75MAPKAPK50.84255581
76CAMKK10.82873805
77MAPK130.82537013
78FLT30.80093935
79DDR20.79406750
80TEC0.79055922
81NME20.79047335
82AKT30.78169224
83RET0.77023975
84MAP3K90.76351388
85PDGFRA0.74140555
86STK380.73749316
87NEK20.73406594
88MAP2K60.72421833
89PIK3CG0.71820809
90TLK10.71030746
91MAPKAPK20.70485222
92MAP3K80.70414558
93LCK0.69877481
94BLK0.69292406
95PRKCG0.69250848
96STK30.68694344
97EGFR0.68061055
98MAP3K110.67454572
99TAOK30.66862094
100CSK0.65678285
101JAK20.65371012
102FGFR40.64751800
103MAP4K10.64001339
104MARK30.63373274
105FES0.62755794
106MAP2K70.60955077
107PDGFRB0.59841577
108PTK2B0.59740229
109EPHB20.59596082
110EEF2K0.56652355
111PIM10.56433172
112CDC42BPA0.55676313
113TAOK20.55088069
114ALK0.54355031
115RPS6KA20.53662366
116PAK10.53425342
117CAMK10.53285361
118MAPKAPK30.53138093
119PRKAA20.52324985
120NTRK10.51573062
121PRKCE0.50606970
122CAMK2A0.50275600
123PRKG20.50252404
124PKN10.49766244
125CAMK2D0.48856941
126KSR20.47209920
127MELK0.46253430
128DAPK30.45690120
129ABL10.45278436
130SYK0.45190460
131MAP2K10.43973877
132PNCK0.43045658
133GRK50.42623976
134RPS6KC10.42124446
135RPS6KL10.42124446
136CAMK2G0.41634051
137PRKCA0.41229025
138DAPK20.41173829
139PAK60.39671813
140INSR0.38446716
141CSNK1G30.37270675
142PRKCH0.37158588
143RPS6KA60.36209177
144CAMK2B0.35581650
145STK40.35385803
146MAP2K20.35050757
147ROCK10.34475438
148GSK3A0.33996253
149WNK10.33895008
150MAPK40.33831563
151TSSK60.33271111
152TESK20.32766295
153PRKCQ0.32208740
154TESK10.31725590
155PDPK10.30954431
156SRC0.30925732
157ERBB40.30046470
158MAPK150.30036671
159OXSR10.30017041

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.43628999
2Leishmaniasis_Homo sapiens_hsa051402.27953555
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.18255089
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.11131546
5Lysosome_Homo sapiens_hsa041422.07100054
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.01687321
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.99638866
8Apoptosis_Homo sapiens_hsa042101.98780022
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96990541
10B cell receptor signaling pathway_Homo sapiens_hsa046621.92337118
11NOD-like receptor signaling pathway_Homo sapiens_hsa046211.91606858
12Asthma_Homo sapiens_hsa053101.89332080
13Phototransduction_Homo sapiens_hsa047441.88713119
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.85325793
15Toxoplasmosis_Homo sapiens_hsa051451.84156567
16TNF signaling pathway_Homo sapiens_hsa046681.80833682
17Shigellosis_Homo sapiens_hsa051311.76033716
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.74484560
19Chronic myeloid leukemia_Homo sapiens_hsa052201.73586612
20Tuberculosis_Homo sapiens_hsa051521.68654281
21Sulfur relay system_Homo sapiens_hsa041221.65523808
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.62810691
23Tryptophan metabolism_Homo sapiens_hsa003801.61977769
24Pertussis_Homo sapiens_hsa051331.61676210
25Measles_Homo sapiens_hsa051621.61451420
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58682065
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54339049
28Ether lipid metabolism_Homo sapiens_hsa005651.50584323
29Staphylococcus aureus infection_Homo sapiens_hsa051501.48307141
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47578604
31Antigen processing and presentation_Homo sapiens_hsa046121.47386206
32Influenza A_Homo sapiens_hsa051641.47220079
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.46713190
34Small cell lung cancer_Homo sapiens_hsa052221.45967964
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45101588
36Phagosome_Homo sapiens_hsa041451.42506608
37Other glycan degradation_Homo sapiens_hsa005111.41950785
38Legionellosis_Homo sapiens_hsa051341.40819885
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38513482
40Linoleic acid metabolism_Homo sapiens_hsa005911.38268554
41Malaria_Homo sapiens_hsa051441.35215397
42Arachidonic acid metabolism_Homo sapiens_hsa005901.35075667
43Salmonella infection_Homo sapiens_hsa051321.34961419
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33456498
45Acute myeloid leukemia_Homo sapiens_hsa052211.29928420
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29161605
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.26589360
48Pancreatic cancer_Homo sapiens_hsa052121.26343041
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26117658
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25611293
51Taste transduction_Homo sapiens_hsa047421.25057396
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24057351
53Olfactory transduction_Homo sapiens_hsa047401.22692008
54ABC transporters_Homo sapiens_hsa020101.22579215
55Selenocompound metabolism_Homo sapiens_hsa004501.22012027
56Butanoate metabolism_Homo sapiens_hsa006501.21051963
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20461066
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.19299620
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18618196
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18474957
61Chemokine signaling pathway_Homo sapiens_hsa040621.18427951
62Morphine addiction_Homo sapiens_hsa050321.17268315
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16397144
64Hepatitis B_Homo sapiens_hsa051611.14739213
65Viral myocarditis_Homo sapiens_hsa054161.14706116
66Epstein-Barr virus infection_Homo sapiens_hsa051691.12634460
67Proteoglycans in cancer_Homo sapiens_hsa052051.11947425
68MicroRNAs in cancer_Homo sapiens_hsa052061.11077965
69Rheumatoid arthritis_Homo sapiens_hsa053231.09731940
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09692748
71Leukocyte transendothelial migration_Homo sapiens_hsa046701.05741532
72Nicotine addiction_Homo sapiens_hsa050331.05556404
73Homologous recombination_Homo sapiens_hsa034401.05300811
74Sphingolipid metabolism_Homo sapiens_hsa006001.05126206
75Hepatitis C_Homo sapiens_hsa051601.03939142
76Calcium signaling pathway_Homo sapiens_hsa040201.03346954
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01459434
78Amoebiasis_Homo sapiens_hsa051461.00508397
79mTOR signaling pathway_Homo sapiens_hsa041500.99052850
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97410700
81Prolactin signaling pathway_Homo sapiens_hsa049170.97254143
82Focal adhesion_Homo sapiens_hsa045100.97187943
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95679890
84Endocytosis_Homo sapiens_hsa041440.94943423
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94737163
86Allograft rejection_Homo sapiens_hsa053300.93553454
87Viral carcinogenesis_Homo sapiens_hsa052030.91746883
88Herpes simplex infection_Homo sapiens_hsa051680.91606713
89Nitrogen metabolism_Homo sapiens_hsa009100.91007027
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.89138363
91Glioma_Homo sapiens_hsa052140.88119025
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.86200400
93Salivary secretion_Homo sapiens_hsa049700.85083958
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84993862
95Platelet activation_Homo sapiens_hsa046110.84153278
96VEGF signaling pathway_Homo sapiens_hsa043700.83964469
97Serotonergic synapse_Homo sapiens_hsa047260.83455115
98Type II diabetes mellitus_Homo sapiens_hsa049300.82992748
99HIF-1 signaling pathway_Homo sapiens_hsa040660.81746736
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78298221
101p53 signaling pathway_Homo sapiens_hsa041150.77286324
102T cell receptor signaling pathway_Homo sapiens_hsa046600.75570450
103HTLV-I infection_Homo sapiens_hsa051660.72975150
104Renal cell carcinoma_Homo sapiens_hsa052110.72916361
105Glutamatergic synapse_Homo sapiens_hsa047240.72137488
106Graft-versus-host disease_Homo sapiens_hsa053320.72006194
107Circadian entrainment_Homo sapiens_hsa047130.71993651
108Adherens junction_Homo sapiens_hsa045200.71802593
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.70190238
110GABAergic synapse_Homo sapiens_hsa047270.68843138
111Dorso-ventral axis formation_Homo sapiens_hsa043200.68179633
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.67435323
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.67419173
114Non-small cell lung cancer_Homo sapiens_hsa052230.67361536
115Prostate cancer_Homo sapiens_hsa052150.66728694
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.66727219
117Insulin secretion_Homo sapiens_hsa049110.65646229
118Colorectal cancer_Homo sapiens_hsa052100.64411624
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.63643627
120Notch signaling pathway_Homo sapiens_hsa043300.63531013
121MAPK signaling pathway_Homo sapiens_hsa040100.63520558
122Autoimmune thyroid disease_Homo sapiens_hsa053200.63222415
123Ovarian steroidogenesis_Homo sapiens_hsa049130.62357476
124Mineral absorption_Homo sapiens_hsa049780.61851245
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61810279
126Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61638866
127Peroxisome_Homo sapiens_hsa041460.61096689
128Hematopoietic cell lineage_Homo sapiens_hsa046400.60291954
129Dilated cardiomyopathy_Homo sapiens_hsa054140.60056321
130African trypanosomiasis_Homo sapiens_hsa051430.59419221
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59082796
132ECM-receptor interaction_Homo sapiens_hsa045120.59021793
133Sulfur metabolism_Homo sapiens_hsa009200.58324533
134Synaptic vesicle cycle_Homo sapiens_hsa047210.58241386
135Glycerolipid metabolism_Homo sapiens_hsa005610.57145436
136Insulin resistance_Homo sapiens_hsa049310.56872409
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55958518
138Inositol phosphate metabolism_Homo sapiens_hsa005620.55728702
139Collecting duct acid secretion_Homo sapiens_hsa049660.55574947
140FoxO signaling pathway_Homo sapiens_hsa040680.55454000
141Bladder cancer_Homo sapiens_hsa052190.55285613
142Melanoma_Homo sapiens_hsa052180.54015225
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53928728
144Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53668067
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53603809
146Prion diseases_Homo sapiens_hsa050200.53288480
147Steroid hormone biosynthesis_Homo sapiens_hsa001400.53131676
148Oxytocin signaling pathway_Homo sapiens_hsa049210.52773231
149Long-term depression_Homo sapiens_hsa047300.52726551
150Estrogen signaling pathway_Homo sapiens_hsa049150.51908611
151Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47863206
152Cholinergic synapse_Homo sapiens_hsa047250.46339031
153Renin secretion_Homo sapiens_hsa049240.45499600
154Type I diabetes mellitus_Homo sapiens_hsa049400.44676381
155Pyrimidine metabolism_Homo sapiens_hsa002400.42622715
156Fanconi anemia pathway_Homo sapiens_hsa034600.41360699
157Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39853016
158Oxidative phosphorylation_Homo sapiens_hsa001900.39601086
159Glutathione metabolism_Homo sapiens_hsa004800.39086830
160Cyanoamino acid metabolism_Homo sapiens_hsa004600.37573159
161Ras signaling pathway_Homo sapiens_hsa040140.37136572

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