ARHGAP24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular epithelial cell development (GO:0072310)9.01252404
2glomerular basement membrane development (GO:0032836)8.51915792
3glomerulus development (GO:0032835)5.04783490
4aminoglycoside antibiotic metabolic process (GO:0030647)5.02661435
5drug transmembrane transport (GO:0006855)4.32898089
6excretion (GO:0007588)4.07700991
7positive regulation of fibroblast migration (GO:0010763)4.05631089
8lysine catabolic process (GO:0006554)4.00541045
9lysine metabolic process (GO:0006553)4.00541045
10blood vessel maturation (GO:0001955)4.00229027
11urate metabolic process (GO:0046415)3.93949608
12kidney mesenchyme development (GO:0072074)3.72454140
13positive regulation of p38MAPK cascade (GO:1900745)3.70501458
14epithelial cell differentiation involved in kidney development (GO:0035850)3.65519897
15surfactant homeostasis (GO:0043129)3.53758846
16metanephric mesenchyme development (GO:0072075)3.49029574
17vascular endothelial growth factor signaling pathway (GO:0038084)3.44203815
18metanephric epithelium development (GO:0072207)3.43574107
19drug transport (GO:0015893)3.39854395
20organic cation transport (GO:0015695)3.26997983
21negative regulation of nitric-oxide synthase activity (GO:0051001)3.24313544
22keratan sulfate catabolic process (GO:0042340)3.22033364
23phosphate ion transport (GO:0006817)3.19552617
24cellular response to vitamin D (GO:0071305)3.17636219
25metanephric nephron tubule development (GO:0072234)3.16220701
26metanephric tubule development (GO:0072170)3.16220701
27renal absorption (GO:0070293)3.13976698
28peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.12247256
29tricarboxylic acid metabolic process (GO:0072350)3.12194881
30valine metabolic process (GO:0006573)3.03437231
31quaternary ammonium group transport (GO:0015697)3.02862564
32cell adhesion mediated by integrin (GO:0033627)3.02838689
33cellular response to vitamin (GO:0071295)2.99658685
34lung vasculature development (GO:0060426)2.99472562
35metanephric nephron epithelium development (GO:0072243)2.97244183
36extracellular fibril organization (GO:0043206)2.95447315
37positive regulation of muscle hypertrophy (GO:0014742)2.88497082
38positive regulation of cardiac muscle hypertrophy (GO:0010613)2.88497082
39response to mercury ion (GO:0046689)2.85467960
40branched-chain amino acid metabolic process (GO:0009081)2.82217929
41toxin transport (GO:1901998)2.81458157
42substrate-dependent cell migration (GO:0006929)2.80623372
43cell migration involved in heart development (GO:0060973)2.77777958
44regulation of cardiac muscle hypertrophy (GO:0010611)2.75888658
45regulation of p38MAPK cascade (GO:1900744)2.75480573
46retina vasculature morphogenesis in camera-type eye (GO:0061299)2.74427803
47regulation of apoptotic process involved in morphogenesis (GO:1902337)2.74320693
48pathway-restricted SMAD protein phosphorylation (GO:0060389)2.74166146
49pyrimidine ribonucleoside catabolic process (GO:0046133)2.74112271
50regulation of muscle hypertrophy (GO:0014743)2.73444296
51regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.73400721
52venous blood vessel morphogenesis (GO:0048845)2.72425502
53chemical homeostasis within a tissue (GO:0048875)2.72381462
54platelet-derived growth factor receptor signaling pathway (GO:0048008)2.68646797
55Golgi transport vesicle coating (GO:0048200)2.68005225
56COPI coating of Golgi vesicle (GO:0048205)2.68005225
57homocysteine metabolic process (GO:0050667)2.67772456
58apoptotic cell clearance (GO:0043277)2.67484595
59renal filtration (GO:0097205)2.65694641
60fibril organization (GO:0097435)2.64587539
61cellular response to ethanol (GO:0071361)2.63583542
62macroautophagy (GO:0016236)2.62395495
63B cell receptor signaling pathway (GO:0050853)2.61772003
64fatty acid beta-oxidation (GO:0006635)2.61476364
65nephron epithelium morphogenesis (GO:0072088)2.59904279
66nephron tubule morphogenesis (GO:0072078)2.59904279
67renal tubule morphogenesis (GO:0061333)2.59794803
68sequestering of extracellular ligand from receptor (GO:0035581)2.58054004
69nephron tubule development (GO:0072080)2.57485071
70carnitine transport (GO:0015879)2.56720020
71amino-acid betaine transport (GO:0015838)2.56720020
72* wound healing, spreading of epidermal cells (GO:0035313)2.56680262
73membrane raft organization (GO:0031579)2.55987972
74production of molecular mediator involved in inflammatory response (GO:0002532)2.55182924
75positive regulation of receptor recycling (GO:0001921)2.54048214
76coronary vasculature morphogenesis (GO:0060977)2.53990538
77smooth muscle tissue development (GO:0048745)2.53100932
78regulation of chemokine-mediated signaling pathway (GO:0070099)2.53022347
79short-chain fatty acid metabolic process (GO:0046459)2.52010658
80regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.51587087
81positive regulation of cell adhesion mediated by integrin (GO:0033630)2.51228677
82chondrocyte proliferation (GO:0035988)2.49961377
83regulation of interferon-beta biosynthetic process (GO:0045357)2.49581471
84glycoside metabolic process (GO:0016137)2.49521843
85regulation of axon guidance (GO:1902667)2.48411465
86actin filament depolymerization (GO:0030042)2.48062723
87macrophage activation involved in immune response (GO:0002281)2.48033590
88drug catabolic process (GO:0042737)2.47022097
89negative regulation of synaptic transmission, GABAergic (GO:0032229)2.46753440
90negative regulation of fatty acid transport (GO:2000192)2.45968185
91renal tubule development (GO:0061326)2.43789856
92peptide catabolic process (GO:0043171)2.42443116
93regulation of fibroblast migration (GO:0010762)2.41799089
94nephron epithelium development (GO:0072009)2.41404260
95regulation of integrin-mediated signaling pathway (GO:2001044)2.39794242
96regulation of dendritic cell antigen processing and presentation (GO:0002604)2.38886258
97endodermal cell differentiation (GO:0035987)2.38404971
98glyoxylate metabolic process (GO:0046487)2.38185404
99regulation of endothelial cell chemotaxis (GO:2001026)2.38175225
100positive regulation of blood vessel endothelial cell migration (GO:0043536)2.37863802
101pericardium development (GO:0060039)2.37128343
102branched-chain amino acid catabolic process (GO:0009083)2.37011689
103sprouting angiogenesis (GO:0002040)2.36617802
104positive regulation of macrophage cytokine production (GO:0060907)2.36300917
105exogenous drug catabolic process (GO:0042738)2.34730473
106protein localization to endosome (GO:0036010)2.34500021
107aspartate family amino acid catabolic process (GO:0009068)2.33520204
108exocrine pancreas development (GO:0031017)2.33295416
109lymphangiogenesis (GO:0001946)2.33198440
110fatty acid oxidation (GO:0019395)2.33114362
111regulation of macrophage cytokine production (GO:0010935)2.31301467
112protein heterotrimerization (GO:0070208)2.30534479
113lipid oxidation (GO:0034440)2.30478129
114endothelium development (GO:0003158)2.29927266
115fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.29435168
116cellular response to epinephrine stimulus (GO:0071872)2.29026248
117negative regulation of axon guidance (GO:1902668)2.28835174
118endothelial cell chemotaxis (GO:0035767)2.28791212
119regulation of type B pancreatic cell apoptotic process (GO:2000674)2.28191069
120phosphate ion transmembrane transport (GO:0035435)2.28050401
121positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.27929982
122axon extension involved in axon guidance (GO:0048846)2.27657860
123neuron projection extension involved in neuron projection guidance (GO:1902284)2.27657860
124cell differentiation involved in kidney development (GO:0061005)2.27407115
125negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.27284517
126regulation of T-helper 2 cell differentiation (GO:0045628)2.26818510
127regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.26447959
128insulin-like growth factor receptor signaling pathway (GO:0048009)2.25477029
129detection of molecule of bacterial origin (GO:0032490)2.25135025
1302-oxoglutarate metabolic process (GO:0006103)2.25074182
131negative regulation of protein autophosphorylation (GO:0031953)2.24127127
132negative regulation of monooxygenase activity (GO:0032769)2.23594024
133negative regulation of anoikis (GO:2000811)2.21910550
134peptide hormone processing (GO:0016486)2.21814415
135negative regulation of metanephros development (GO:0072217)2.21638705
136trivalent inorganic anion homeostasis (GO:0072506)2.21496670
137phosphate ion homeostasis (GO:0055062)2.21496670
138positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.21342379
139collagen fibril organization (GO:0030199)2.21250118
140diaphragm development (GO:0060539)2.21049905
141regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.19949226
142negative regulation of endothelial cell proliferation (GO:0001937)2.19740703
143positive regulation of glycolytic process (GO:0045821)2.18333426
144vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.18255112
145polyol transport (GO:0015791)2.17228679
146histamine secretion (GO:0001821)2.17048878
147artery development (GO:0060840)2.16716506
148regulation of alkaline phosphatase activity (GO:0010692)2.16027284
149energy homeostasis (GO:0097009)2.15455509
150nonribosomal peptide biosynthetic process (GO:0019184)2.14842919
151regulation of muscle adaptation (GO:0043502)2.14502788
152type B pancreatic cell proliferation (GO:0044342)2.13274296
153glomerular filtration (GO:0003094)2.13249377
154cell migration involved in sprouting angiogenesis (GO:0002042)2.12944687
155skin morphogenesis (GO:0043589)2.12656646
156regulation of extracellular matrix disassembly (GO:0010715)2.11521947
157regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.11364288
158collagen metabolic process (GO:0032963)2.10737667
159angiotensin maturation (GO:0002003)2.10482133
160cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.10004802
161endocrine hormone secretion (GO:0060986)2.09081257
162positive regulation of catenin import into nucleus (GO:0035413)2.08982445
163extracellular matrix assembly (GO:0085029)2.07761074
164inositol phosphate-mediated signaling (GO:0048016)2.05082445
165collagen catabolic process (GO:0030574)2.04302709
166chondrocyte development (GO:0002063)2.03812672
167regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.03664021
168regulation of sarcomere organization (GO:0060297)2.02443916
169positive regulation of smooth muscle cell migration (GO:0014911)2.02393653
170response to epinephrine (GO:0071871)2.02103258
171gland morphogenesis (GO:0022612)2.01963967
172negative regulation of adherens junction organization (GO:1903392)2.01040516
173negative regulation of focal adhesion assembly (GO:0051895)2.01040516
174negative regulation of cell junction assembly (GO:1901889)2.01040516
175positive regulation of actin filament depolymerization (GO:0030836)2.01001173
176glomerular visceral epithelial cell development (GO:0072015)10.1593453
177positive regulation of endothelial cell migration (GO:0010595)1.98885283
178barbed-end actin filament capping (GO:0051016)1.98386472
179positive regulation of cellular amide metabolic process (GO:0034250)1.97555947
180regulation of cardiac muscle cell differentiation (GO:2000725)1.95555520
181negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)1.94334883
182negative regulation of T-helper cell differentiation (GO:0045623)1.94334883
183macrophage activation (GO:0042116)1.94282444
184dermatan sulfate biosynthetic process (GO:0030208)1.93844664
185response to magnesium ion (GO:0032026)1.93641802
186regulation of B cell receptor signaling pathway (GO:0050855)1.93565055
187regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)1.93230720
188response to gravity (GO:0009629)1.93006783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.31876887
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.02335454
3ESR1_21235772_ChIP-Seq_MCF-7_Human2.49355105
4ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.19412519
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.16168951
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.13722939
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10936314
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.04410792
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04165675
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01663165
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95830108
12CLOCK_20551151_ChIP-Seq_293T_Human1.88540115
13EP300_21415370_ChIP-Seq_HL-1_Mouse1.82722687
14GBX2_23144817_ChIP-Seq_PC3_Human1.79334651
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.74799107
16ESR2_21235772_ChIP-Seq_MCF-7_Human1.73099851
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.69591058
18RXR_22158963_ChIP-Seq_LIVER_Mouse1.67618232
19* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67541131
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64648278
21TP53_16413492_ChIP-PET_HCT116_Human1.64215943
22* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.59156321
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55647813
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55382787
25* LXR_22158963_ChIP-Seq_LIVER_Mouse1.54662854
26GATA2_21666600_ChIP-Seq_HMVEC_Human1.52067866
27WT1_19549856_ChIP-ChIP_CCG9911_Human1.51962051
28CJUN_26792858_Chip-Seq_BT549_Human1.48960410
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46625146
30WT1_25993318_ChIP-Seq_PODOCYTE_Human1.44095807
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40583159
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38543823
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38319047
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.37729534
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37546707
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37485605
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36359211
38NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36359211
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.35989073
40* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34780237
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34777625
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32979141
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32979141
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31651614
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29981359
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29027117
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28593540
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27273611
49* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.27049987
50FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27006029
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26420140
52* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26286298
53* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25461017
54FOXA2_19822575_ChIP-Seq_HepG2_Human1.23993039
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23190508
56RXR_22108803_ChIP-Seq_LS180_Human1.22525167
57* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21191639
58* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21186699
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20600301
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18963254
61* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18159018
62RUNX_20019798_ChIP-Seq_JUKART_Human1.17167465
63* AHR_22903824_ChIP-Seq_MCF-7_Human1.17024358
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16705945
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16258699
66TBX20_22328084_ChIP-Seq_HEART_Mouse1.15668928
67TBX20_22080862_ChIP-Seq_HEART_Mouse1.15668928
68* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15144943
69* ARNT_22903824_ChIP-Seq_MCF-7_Human1.14743966
70* SMAD3_21741376_ChIP-Seq_HESCs_Human1.14078692
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.14000820
72SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13091281
73SOX2_20726797_ChIP-Seq_SW620_Human1.12221152
74PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12171201
75* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11514025
76SMAD4_21799915_ChIP-Seq_A2780_Human1.10233554
77JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08324726
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07276722
79BCAT_22108803_ChIP-Seq_LS180_Human1.06952922
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.05950140
81* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05728760
82* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05620511
83TP53_18474530_ChIP-ChIP_U2OS_Human1.03594286
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03215607
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.03083196
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02863431
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02636273
88VDR_24787735_ChIP-Seq_THP-1_Human1.01328515
89* P300_19829295_ChIP-Seq_ESCs_Human1.01131091
90NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99613742
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99513199
92DROSHA_22980978_ChIP-Seq_HELA_Human0.99214150
93SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98875060
94* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98831098
95* STAT3_23295773_ChIP-Seq_U87_Human0.98492586
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.97899389
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97765931
98* EZH2_27294783_Chip-Seq_ESCs_Mouse0.96774314
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96611581
100NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96009822
101* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95329499
102KDM2B_26808549_Chip-Seq_REH_Human0.95047458
103* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94884458
104TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94863139
105FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94763267
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94584448
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93969795
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93671917
109TP63_23658742_ChIP-Seq_EP156T_Human0.93466359
110FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92182170
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92080525
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91637459
113JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91550933
114FLI1_27457419_Chip-Seq_LIVER_Mouse0.91435387
115CDX2_20551321_ChIP-Seq_CACO-2_Human0.90936486
116NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90917364
117IRF8_22096565_ChIP-ChIP_GC-B_Human0.88727879
118CDX2_22108803_ChIP-Seq_LS180_Human0.88694029
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88004411
120* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87982743
121* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87058755
122GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86760745
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86685883
124SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86674698
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86438094
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85787790
127* TCF4_22108803_ChIP-Seq_LS180_Human0.85741075
128SMAD_19615063_ChIP-ChIP_OVARY_Human0.84921998
129E2F1_18555785_Chip-Seq_ESCs_Mouse0.84912875
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84822280
131SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83726909
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.83602924
133BRD4_25478319_ChIP-Seq_HGPS_Human0.83536226
134IGF1R_20145208_ChIP-Seq_DFB_Human0.83294710
135YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83174400
136* SOX2_21211035_ChIP-Seq_LN229_Gbm0.83110421
137* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83062678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation4.21536492
2MP0003195_calcinosis3.39620849
3MP0003950_abnormal_plasma_membrane2.83843949
4MP0005360_urolithiasis2.82186857
5MP0005332_abnormal_amino_acid2.79537607
6MP0009643_abnormal_urine_homeostasis2.77273123
7MP0004272_abnormal_basement_membrane2.66316863
8MP0001756_abnormal_urination2.64877306
9MP0005503_abnormal_tendon_morphology2.60513264
10MP0008438_abnormal_cutaneous_collagen2.60238769
11MP0006054_spinal_hemorrhage2.47235793
12MP0001958_emphysema2.42844796
13MP0002138_abnormal_hepatobiliary_system2.37999014
14MP0010386_abnormal_urinary_bladder2.31554560
15MP0003283_abnormal_digestive_organ2.31045349
16MP0002136_abnormal_kidney_physiology2.26231369
17MP0004019_abnormal_vitamin_homeostasis2.23936268
18MP0001765_abnormal_ion_homeostasis2.19704566
19MP0003252_abnormal_bile_duct2.14769575
20MP0000767_abnormal_smooth_muscle2.13452851
21MP0000013_abnormal_adipose_tissue2.13408553
22MP0008961_abnormal_basal_metabolism2.12018055
23MP0005058_abnormal_lysosome_morphology2.05078026
24MP0002139_abnormal_hepatobiliary_system2.03148851
25MP0001879_abnormal_lymphatic_vessel2.03133125
26MP0003828_pulmonary_edema1.95956724
27MP0003303_peritoneal_inflammation1.95265016
28MP0005623_abnormal_meninges_morphology1.93815809
29MP0008004_abnormal_stomach_pH1.90279444
30MP0005670_abnormal_white_adipose1.89918418
31MP0000569_abnormal_digit_pigmentation1.85657647
32MP0000230_abnormal_systemic_arterial1.84689364
33MP0001661_extended_life_span1.83995606
34MP0004084_abnormal_cardiac_muscle1.78113427
35MP0003191_abnormal_cellular_cholesterol1.78095823
36MP0001542_abnormal_bone_strength1.77010643
37MP0010368_abnormal_lymphatic_system1.76897438
38MP0005275_abnormal_skin_tensile1.75010080
39MP0004233_abnormal_muscle_weight1.71972993
40MP0002928_abnormal_bile_duct1.64924126
41MP0003724_increased_susceptibility_to1.63197663
42MP0003300_gastrointestinal_ulcer1.58060060
43MP0009780_abnormal_chondrocyte_physiolo1.55553557
44MP0002837_dystrophic_cardiac_calcinosis1.55369726
45MP0002168_other_aberrant_phenotype1.55194912
46MP0002896_abnormal_bone_mineralization1.54945174
47MP0004883_abnormal_blood_vessel1.51545540
48MP0002135_abnormal_kidney_morphology1.47135068
49MP0002332_abnormal_exercise_endurance1.41007510
50MP0004036_abnormal_muscle_relaxation1.40889537
51MP0004510_myositis1.39016298
52MP0005220_abnormal_exocrine_pancreas1.38759075
53MP0000534_abnormal_ureter_morphology1.38382025
54MP0004484_altered_response_of1.36963819
55MP0003172_abnormal_lysosome_physiology1.36334056
56MP0000003_abnormal_adipose_tissue1.34220174
57MP0002108_abnormal_muscle_morphology1.33715002
58MP0003705_abnormal_hypodermis_morpholog1.33690363
59MP0005636_abnormal_mineral_homeostasis1.32700189
60MP0005365_abnormal_bile_salt1.32314800
61MP0005164_abnormal_response_to1.31024235
62MP0002090_abnormal_vision1.30308218
63MP0000678_abnormal_parathyroid_gland1.29581547
64MP0003941_abnormal_skin_development1.28887991
65MP0009384_cardiac_valve_regurgitation1.28541010
66MP0001270_distended_abdomen1.26064189
67MP0005023_abnormal_wound_healing1.22888754
68MP0003183_abnormal_peptide_metabolism1.22504811
69MP0003045_fibrosis1.21664830
70MP0006072_abnormal_retinal_apoptosis1.19055935
71MP0003942_abnormal_urinary_system1.15807030
72MP0008775_abnormal_heart_ventricle1.14794093
73MP0003279_aneurysm1.14333128
74MP0005375_adipose_tissue_phenotype1.13545827
75MP0005257_abnormal_intraocular_pressure1.12751664
76MP0005551_abnormal_eye_electrophysiolog1.11164395
77MP0005666_abnormal_adipose_tissue1.10447614
78MP0001944_abnormal_pancreas_morphology1.10261847
79MP0002933_joint_inflammation1.09851454
80MP0002998_abnormal_bone_remodeling1.09790458
81MP0001299_abnormal_eye_distance/1.09522864
82MP0000538_abnormal_urinary_bladder1.06228194
83MP0003959_abnormal_lean_body1.05109196
84MP0002295_abnormal_pulmonary_circulatio1.02197516
85MP0001835_abnormal_antigen_presentation1.02102318
86MP0003566_abnormal_cell_adhesion1.00619788
87MP0001790_abnormal_immune_system0.96958058
88MP0005387_immune_system_phenotype0.96958058
89MP0004145_abnormal_muscle_electrophysio0.96807660
90MP0000249_abnormal_blood_vessel0.95990219
91MP0001533_abnormal_skeleton_physiology0.94231228
92MP0002078_abnormal_glucose_homeostasis0.91879079
93MP0002877_abnormal_melanocyte_morpholog0.91766149
94MP0005165_increased_susceptibility_to0.90345358
95MP0000163_abnormal_cartilage_morphology0.89879228
96MP0001324_abnormal_eye_pigmentation0.88344818
97MP0005390_skeleton_phenotype0.87411299
98MP0002972_abnormal_cardiac_muscle0.86947785
99MP0005167_abnormal_blood-brain_barrier0.86340693
100MP0002115_abnormal_skeleton_extremities0.85719915
101MP0000747_muscle_weakness0.85591282
102MP0005388_respiratory_system_phenotype0.85350435
103MP0002133_abnormal_respiratory_system0.85350435
104MP0000343_altered_response_to0.85147637
105MP0005620_abnormal_muscle_contractility0.84438897
106MP0010030_abnormal_orbit_morphology0.83249393
107MP0005535_abnormal_body_temperature0.82970661
108MP0002909_abnormal_adrenal_gland0.82748586
109MP0003868_abnormal_feces_composition0.82263097
110MP0005197_abnormal_uvea_morphology0.82182921
111MP0000759_abnormal_skeletal_muscle0.81965684
112MP0002693_abnormal_pancreas_physiology0.81374300
113MP0002128_abnormal_blood_circulation0.80756929
114MP0005595_abnormal_vascular_smooth0.80749687
115MP0004215_abnormal_myocardial_fiber0.79701220
116MP0000749_muscle_degeneration0.79679698
117MP0002127_abnormal_cardiovascular_syste0.79635191
118MP0010352_gastrointestinal_tract_polyps0.78850041
119MP0000465_gastrointestinal_hemorrhage0.77405796
120MP0005508_abnormal_skeleton_morphology0.77021258
121MP0003795_abnormal_bone_structure0.76709091
122MP0004130_abnormal_muscle_cell0.76558002
123MP0004087_abnormal_muscle_fiber0.76496348
124MP0003075_altered_response_to0.75074460
125MP0000733_abnormal_muscle_development0.74128009
126MP0005369_muscle_phenotype0.73640389
127MP0004185_abnormal_adipocyte_glucose0.71440492
128MP0005000_abnormal_immune_tolerance0.70145777
129MP0001614_abnormal_blood_vessel0.69290789
130MP0005084_abnormal_gallbladder_morpholo0.67314517
131MP0003690_abnormal_glial_cell0.67232722
132MP0000751_myopathy0.67148461
133MP0003011_delayed_dark_adaptation0.66840323
134MP0005319_abnormal_enzyme/_coenzyme0.65762033
135MP0002971_abnormal_brown_adipose0.65742116
136MP0005166_decreased_susceptibility_to0.65587426
137MP0002060_abnormal_skin_morphology0.65112480
138MP0005253_abnormal_eye_physiology0.64968061
139MP0002118_abnormal_lipid_homeostasis0.63803944
140MP0001243_abnormal_dermal_layer0.63536604
141MP0000685_abnormal_immune_system0.63345870
142MP0001800_abnormal_humoral_immune0.63258068
143MP0005330_cardiomyopathy0.63193467
144MP0006082_CNS_inflammation0.62751110
145MP0006138_congestive_heart_failure0.62382165
146MP0002697_abnormal_eye_size0.59838504
147MP0003091_abnormal_cell_migration0.59625221
148MP0002269_muscular_atrophy0.58837010
149MP0000750_abnormal_muscle_regeneration0.57045491

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)6.29779786
2Hypokalemic alkalosis (HP:0001949)6.02416462
3Metabolic alkalosis (HP:0200114)5.58391696
4Hypomagnesemia (HP:0002917)5.35035673
5Hyperactive renin-angiotensin system (HP:0000841)5.33908264
6Protrusio acetabuli (HP:0003179)5.27953159
7Aortic dissection (HP:0002647)5.24539159
8Abnormality of chloride homeostasis (HP:0011422)5.10306208
9Polyuria (HP:0000103)4.90991677
10Vascular tortuosity (HP:0004948)4.84674669
11Focal segmental glomerulosclerosis (HP:0000097)4.68188240
12Arterial tortuosity (HP:0005116)4.65561269
13Tetany (HP:0001281)4.58197683
14Abnormal urine output (HP:0012590)4.55546653
15Abnormality of magnesium homeostasis (HP:0004921)4.36281412
16Gout (HP:0001997)4.30890074
17Polydipsia (HP:0001959)4.26520447
18Abnormal drinking behavior (HP:0030082)4.26520447
19Abnormality of renal excretion (HP:0011036)4.20556309
20Abnormality of renin-angiotensin system (HP:0000847)4.11479560
21Glomerulosclerosis (HP:0000096)3.99719152
22Hypokalemia (HP:0002900)3.90035041
23Hyperaldosteronism (HP:0000859)3.74701211
24Mesangial abnormality (HP:0001966)3.63053875
25Alkalosis (HP:0001948)3.53216093
26Type 1 muscle fiber predominance (HP:0003803)3.52714910
27Hematochezia (HP:0002573)3.49477182
28Spondylolisthesis (HP:0003302)3.44370116
29Ketoacidosis (HP:0001993)3.35385061
30Tubular atrophy (HP:0000092)3.33583279
31Soft skin (HP:0000977)3.30523367
32Abnormality of potassium homeostasis (HP:0011042)3.24354319
33Overgrowth (HP:0001548)3.13602494
34Proximal tubulopathy (HP:0000114)3.10678238
35Renal salt wasting (HP:0000127)3.08746084
36Round ear (HP:0100830)3.06826618
37Abnormality of proline metabolism (HP:0010907)2.99200978
38Hydroxyprolinuria (HP:0003080)2.99200978
39Wrist flexion contracture (HP:0001239)2.98067076
40Increased purine levels (HP:0004368)2.97971130
41Hyperuricemia (HP:0002149)2.97971130
42Mitral valve prolapse (HP:0001634)2.97535535
43Abnormality of glutamine family amino acid metabolism (HP:0010902)2.96427455
44Peritonitis (HP:0002586)2.96190736
45Dilatation of the ascending aorta (HP:0005111)2.95735917
46Abnormality of purine metabolism (HP:0004352)2.95705256
47Hypophosphatemia (HP:0002148)2.91652379
48Hypercalciuria (HP:0002150)2.91538511
49Cervical subluxation (HP:0003308)2.87252477
50Stage 5 chronic kidney disease (HP:0003774)2.85599011
51Follicular hyperkeratosis (HP:0007502)2.85372167
52Generalized aminoaciduria (HP:0002909)2.83087287
53Striae distensae (HP:0001065)2.82683371
54Tubulointerstitial fibrosis (HP:0005576)2.82551101
55Nephritis (HP:0000123)2.79487662
56Hypoalbuminemia (HP:0003073)2.78171703
57Abnormal albumin level (HP:0012116)2.78171703
58Lymphangioma (HP:0100764)2.77259745
59Abnormality of calcium-phosphate metabolism (HP:0100530)2.76087975
60Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.68108273
61Congenital stationary night blindness (HP:0007642)2.66762753
62Nemaline bodies (HP:0003798)2.63162389
63Spontaneous hematomas (HP:0007420)2.55401445
64Hyporeflexia of lower limbs (HP:0002600)2.55387010
65Increased variability in muscle fiber diameter (HP:0003557)2.54673503
66Genu recurvatum (HP:0002816)2.54124035
67Facial shape deformation (HP:0011334)2.50655705
68Potter facies (HP:0002009)2.50655705
69Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.43990014
70Metaphyseal cupping (HP:0003021)2.41959004
71Glomerulonephritis (HP:0000099)2.41949580
72Gastrointestinal stroma tumor (HP:0100723)2.41823076
73Ketosis (HP:0001946)2.41597647
74Nephrocalcinosis (HP:0000121)2.40883217
75Emphysema (HP:0002097)2.39856214
76Atrophic scars (HP:0001075)2.39060614
77Hyperglycinuria (HP:0003108)2.35789457
78Blue sclerae (HP:0000592)2.33716321
79Spinal rigidity (HP:0003306)2.33298202
80Wormian bones (HP:0002645)2.28498642
81Hypoglycemic coma (HP:0001325)2.27501314
82Distal arthrogryposis (HP:0005684)2.26491425
83Aneurysm (HP:0002617)2.26181736
84Muscle fiber inclusion bodies (HP:0100299)2.24374252
85Ankle contracture (HP:0006466)2.24031033
86Renal tubular acidosis (HP:0001947)2.22950678
87Aortic valve stenosis (HP:0001650)2.21518432
88Abnormality of skeletal muscle fiber size (HP:0012084)2.20906789
89Mucopolysacchariduria (HP:0008155)2.20799231
90Urinary glycosaminoglycan excretion (HP:0003541)2.20799231
91Asymmetric septal hypertrophy (HP:0001670)2.20036669
92Agammaglobulinemia (HP:0004432)2.19988457
93Vacuolated lymphocytes (HP:0001922)2.19076027
94Dysostosis multiplex (HP:0000943)2.18117676
95Abnormality of polysaccharide metabolism (HP:0011012)2.17812432
96Abnormality of glycosaminoglycan metabolism (HP:0004371)2.17812432
97Abnormality of mucopolysaccharide metabolism (HP:0011020)2.17812432
98Adrenal overactivity (HP:0002717)2.17688749
99Bladder diverticulum (HP:0000015)2.16217639
100Abnormality of fatty-acid metabolism (HP:0004359)2.10311213
101Broad metatarsal (HP:0001783)2.09372960
102Decreased circulating renin level (HP:0003351)2.09281114
103Chondrocalcinosis (HP:0000934)2.08651451
104Fragile skin (HP:0001030)2.06482752
105Slender build (HP:0001533)2.06402391
106Aortic aneurysm (HP:0004942)2.05668315
107Enlarged kidneys (HP:0000105)2.05106551
108Hypoplasia of the iris (HP:0007676)2.04807164
109Flexion contracture of toe (HP:0005830)2.04474237
110Joint contractures involving the joints of the feet (HP:0100492)2.04474237
111Central scotoma (HP:0000603)2.03603041
112Retinal atrophy (HP:0001105)2.03468173
113Camptodactyly of toe (HP:0001836)2.03232957
114Abnormality of Sharpey fibers (HP:0100685)2.01981383
115Ovoid vertebral bodies (HP:0003300)2.01092520
116Limited hip movement (HP:0008800)2.00522146
117Joint laxity (HP:0001388)2.00065516
118Abnormality of dentin (HP:0010299)1.98505189
119Hyperextensible skin (HP:0000974)1.97506671
120Mesomelia (HP:0003027)1.97254751
121Neonatal short-limb short stature (HP:0008921)1.96419285
122Generalized muscle weakness (HP:0003324)1.95995217
123Thin bony cortex (HP:0002753)1.95504751
124Abnormality of urine glucose concentration (HP:0011016)1.94494645
125Glycosuria (HP:0003076)1.94494645
126Cardiovascular calcification (HP:0011915)1.94335351
127Ulnar deviation of the wrist (HP:0003049)1.92948493
128Hypoplastic ischia (HP:0003175)1.92481919
129Delayed epiphyseal ossification (HP:0002663)1.91858477
130Bundle branch block (HP:0011710)1.90463314
131Premature rupture of membranes (HP:0001788)1.88917841
132Tubulointerstitial abnormality (HP:0001969)1.87640494
133Hypoglycemic seizures (HP:0002173)1.87254219
134Osteolytic defects of the hand bones (HP:0009699)1.87157381
135Osteolytic defects of the phalanges of the hand (HP:0009771)1.87157381
136Aortic regurgitation (HP:0001659)1.87028722
137Cerebral aneurysm (HP:0004944)1.86652126
138Symptomatic seizures (HP:0011145)1.85670595
139Polycythemia (HP:0001901)1.85605665
140Bradycardia (HP:0001662)1.84913065
141Abnormal urine phosphate concentration (HP:0012599)1.84631169
142Metaphyseal dysplasia (HP:0100255)1.83564163
143Glucose intolerance (HP:0000833)1.83526382
144Abnormality of the ischium (HP:0003174)1.83281239
145Vascular calcification (HP:0004934)1.82052751
146Progressive visual loss (HP:0000529)1.81824490
147Abnormal tarsal ossification (HP:0008369)1.81166397
148Cellulitis (HP:0100658)1.81081104
149Nephrotic syndrome (HP:0000100)1.80929461
150Mild short stature (HP:0003502)1.79925437
151Joint stiffness (HP:0001387)1.77805246
152Difficulty running (HP:0009046)1.76852568
153Hyperphosphaturia (HP:0003109)1.76749652
154Muscle fiber splitting (HP:0003555)1.76436228
155Thoracolumbar scoliosis (HP:0002944)1.74955858
156Abnormality of the calf musculature (HP:0001430)1.74558052
157Hip contracture (HP:0003273)1.74350294
158Hypoplasia of the odontoid process (HP:0003311)1.74040744
159Nephrolithiasis (HP:0000787)1.74030580
160Mitral stenosis (HP:0001718)1.73869260
161Abnormality of nucleobase metabolism (HP:0010932)1.72917336
162Hyperkalemia (HP:0002153)1.72331452
163Absent frontal sinuses (HP:0002688)1.70510432
164Long toe (HP:0010511)1.69770874
165Papilledema (HP:0001085)1.69345747
166Abnormality of macular pigmentation (HP:0008002)1.69210859
167Recurrent bronchitis (HP:0002837)1.69059102
168Ectopia lentis (HP:0001083)1.68608937
169Conjunctival telangiectasia (HP:0000524)1.68238442
170Proteinuria (HP:0000093)1.68189957
171Abnormal pancreas size (HP:0012094)1.67676309
172Abnormal enzyme/coenzyme activity (HP:0012379)1.67615652
173Popliteal pterygium (HP:0009756)1.67548426
174Abnormality of serine family amino acid metabolism (HP:0010894)1.66790160
175Abnormality of glycine metabolism (HP:0010895)1.66790160
176Pigmentary retinal degeneration (HP:0001146)1.66757459
177Increased connective tissue (HP:0009025)1.66628714
178Mucosal telangiectasiae (HP:0100579)1.64775858
179Bell-shaped thorax (HP:0001591)1.64653731
180Mildly elevated creatine phosphokinase (HP:0008180)1.60759583
181Knee flexion contracture (HP:0006380)1.59332764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK46.71292418
2WNK35.21641604
3OXSR14.46897826
4STK392.90656824
5INSRR2.89543398
6MAP3K122.89332633
7BLK2.15802721
8RIPK42.11950624
9TGFBR22.09725519
10BMPR22.07015502
11EPHB21.88819617
12FRK1.88467429
13SIK11.80966584
14STK38L1.72627829
15EPHA31.69401059
16WNK11.69357304
17MUSK1.62970046
18ERN11.59567327
19LIMK11.56608725
20PDGFRA1.54147531
21BCKDK1.50413804
22PTK2B1.47226332
23LATS11.47005189
24MYLK1.45759296
25MOS1.42877799
26TRIB31.36485091
27CAMK1D1.33796714
28SGK2231.29991097
29SGK4941.29991097
30FGFR41.24080665
31SGK21.23882254
32FER1.20599380
33GRK71.18307151
34CAMK1G1.17272087
35TIE11.16943621
36PTK61.14782805
37SGK31.13817800
38MAP3K31.10817476
39RIPK11.06099410
40NTRK31.06052864
41MAP2K31.05526734
42TTN1.03833640
43IRAK31.03745997
44PRKD31.03570307
45JAK11.03061136
46NTRK11.02703316
47TEC0.99961981
48IRAK20.99911867
49PRKCH0.95519915
50PAK30.95460710
51GRK10.94478077
52PIK3CG0.93988127
53CSK0.93744832
54PAK60.93607342
55MAP3K20.89494857
56PLK20.87727003
57IRAK10.87234645
58ROCK20.86677857
59PTK20.86571884
60TAOK30.86462754
61SIK30.85005919
62MAPK70.84265093
63PAK40.84052652
64PRKAA10.82322189
65FES0.82215357
66MAP3K140.81076020
67PDK20.80817730
68NEK90.80199161
69JAK30.79948924
70* ROCK10.79481947
71MARK20.79187683
72MAP3K70.77326425
73IRAK40.76874034
74DYRK1B0.76205101
75PRKD20.74554545
76SYK0.73930261
77EPHB10.72740877
78MAPK150.72202363
79HCK0.72190998
80STK380.67776639
81CSF1R0.67540904
82PRKAA20.67256047
83GSK3A0.66136702
84PDK10.65711472
85HIPK20.65048080
86TESK10.64925680
87NLK0.64484171
88PDK40.63351620
89PDK30.63351620
90MAP3K130.61646365
91TYK20.60909254
92ZAP700.60743341
93BTK0.59907298
94PRKCE0.59718487
95SGK10.58999975
96OBSCN0.56786317
97PDGFRB0.56205817
98MAP3K60.54004630
99ABL10.52318559
100ERBB30.52244481
101IKBKE0.52126179
102DDR20.51952275
103GRK50.50681884
104MST1R0.50263966
105FGFR30.50152598
106PINK10.49539147
107CDC42BPA0.49140493
108AKT30.47942440
109PHKG10.47581183
110PHKG20.47581183
111DMPK0.46799063
112MAP4K10.46574901
113TBK10.46440180
114FGFR20.44164542
115MAP2K10.43921967
116MAP3K50.43561778
117SIK20.43092529
118CHUK0.41811431
119ADRBK10.40998803
120KIT0.39974330
121IGF1R0.39118529
122MTOR0.38766468
123STK100.38078435
124JAK20.37692261
125PRKG20.35660882
126DAPK20.35432937
127PRKD10.33573958
128MET0.32885311
129TRPM70.31896713
130PRKACG0.31832066
131CAMKK20.31756250
132SRC0.28239365
133INSR0.27662862
134MAPK120.26425883
135MAP3K10.26144577
136RPS6KA20.25652251
137MARK30.24738007
138STK30.23895572
139PAK20.23427985
140PDPK10.23412860
141PIK3CA0.23110495

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.44304835
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37945125
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.33412210
4Protein digestion and absorption_Homo sapiens_hsa049742.29000127
5Propanoate metabolism_Homo sapiens_hsa006402.15156229
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.11811015
7Butanoate metabolism_Homo sapiens_hsa006502.09241088
8Collecting duct acid secretion_Homo sapiens_hsa049662.04112564
9Fatty acid degradation_Homo sapiens_hsa000711.85673228
10ECM-receptor interaction_Homo sapiens_hsa045121.84832790
11B cell receptor signaling pathway_Homo sapiens_hsa046621.68731131
12Staphylococcus aureus infection_Homo sapiens_hsa051501.67279498
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.63517560
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.62481544
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.61245264
16Leishmaniasis_Homo sapiens_hsa051401.59761335
17Sulfur metabolism_Homo sapiens_hsa009201.58888842
18Tryptophan metabolism_Homo sapiens_hsa003801.57531885
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56424743
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56189429
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54524733
22Asthma_Homo sapiens_hsa053101.52163850
23Lysosome_Homo sapiens_hsa041421.45737565
24Lysine degradation_Homo sapiens_hsa003101.42812792
25Peroxisome_Homo sapiens_hsa041461.41042668
26Fatty acid metabolism_Homo sapiens_hsa012121.40745681
27Renin-angiotensin system_Homo sapiens_hsa046141.40569806
28Osteoclast differentiation_Homo sapiens_hsa043801.40048251
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39303924
30Toxoplasmosis_Homo sapiens_hsa051451.38114981
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.37849579
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.35480280
33Other glycan degradation_Homo sapiens_hsa005111.33638759
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24354763
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24297467
36Tuberculosis_Homo sapiens_hsa051521.23909819
37Viral myocarditis_Homo sapiens_hsa054161.23696265
38Malaria_Homo sapiens_hsa051441.20660698
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20529170
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20460476
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19383018
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.18583600
43Autoimmune thyroid disease_Homo sapiens_hsa053201.18296734
44Platelet activation_Homo sapiens_hsa046111.16077865
45Focal adhesion_Homo sapiens_hsa045101.15623714
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.12214096
47Phototransduction_Homo sapiens_hsa047441.12190785
48Dorso-ventral axis formation_Homo sapiens_hsa043201.11963913
49Graft-versus-host disease_Homo sapiens_hsa053321.11239653
50Starch and sucrose metabolism_Homo sapiens_hsa005001.09898464
51Allograft rejection_Homo sapiens_hsa053301.09390122
52Dilated cardiomyopathy_Homo sapiens_hsa054141.09323644
53PPAR signaling pathway_Homo sapiens_hsa033201.07002443
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05615445
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05491136
56Pertussis_Homo sapiens_hsa051331.04576625
57Mineral absorption_Homo sapiens_hsa049781.04025905
58Pyruvate metabolism_Homo sapiens_hsa006201.03182114
59Insulin secretion_Homo sapiens_hsa049111.02943091
60Bile secretion_Homo sapiens_hsa049761.02550494
61Vitamin digestion and absorption_Homo sapiens_hsa049770.99453763
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99116630
63Hematopoietic cell lineage_Homo sapiens_hsa046400.97883349
64Amoebiasis_Homo sapiens_hsa051460.95673744
65Type I diabetes mellitus_Homo sapiens_hsa049400.94247003
66beta-Alanine metabolism_Homo sapiens_hsa004100.94022997
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.93052175
68Vibrio cholerae infection_Homo sapiens_hsa051100.92304430
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89947721
70Type II diabetes mellitus_Homo sapiens_hsa049300.89615050
71Insulin resistance_Homo sapiens_hsa049310.88880375
72GnRH signaling pathway_Homo sapiens_hsa049120.88740747
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88035686
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87459452
75Rap1 signaling pathway_Homo sapiens_hsa040150.84700081
76Thyroid hormone synthesis_Homo sapiens_hsa049180.81375640
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80735311
78Complement and coagulation cascades_Homo sapiens_hsa046100.80683879
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.80021167
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78404053
81Oxytocin signaling pathway_Homo sapiens_hsa049210.78205378
82TGF-beta signaling pathway_Homo sapiens_hsa043500.77942619
83Synaptic vesicle cycle_Homo sapiens_hsa047210.76777547
84Long-term potentiation_Homo sapiens_hsa047200.76400619
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76172912
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75770580
87Phenylalanine metabolism_Homo sapiens_hsa003600.75132797
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73405873
89Ras signaling pathway_Homo sapiens_hsa040140.72982757
90Rheumatoid arthritis_Homo sapiens_hsa053230.72763505
91cAMP signaling pathway_Homo sapiens_hsa040240.72124826
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71806730
93Endocytosis_Homo sapiens_hsa041440.70858885
94TNF signaling pathway_Homo sapiens_hsa046680.70259490
95Phagosome_Homo sapiens_hsa041450.70059424
96FoxO signaling pathway_Homo sapiens_hsa040680.70043394
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69842376
98Salivary secretion_Homo sapiens_hsa049700.69430182
99Glioma_Homo sapiens_hsa052140.69397049
100ABC transporters_Homo sapiens_hsa020100.68844456
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.68593595
102Calcium signaling pathway_Homo sapiens_hsa040200.67164915
103Pancreatic secretion_Homo sapiens_hsa049720.66530407
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.65977913
105Small cell lung cancer_Homo sapiens_hsa052220.65522030
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.65463475
107African trypanosomiasis_Homo sapiens_hsa051430.65411238
108Carbon metabolism_Homo sapiens_hsa012000.65068441
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64867583
110Glycerolipid metabolism_Homo sapiens_hsa005610.63621111
111Influenza A_Homo sapiens_hsa051640.63594127
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61842535
113Sphingolipid metabolism_Homo sapiens_hsa006000.61210816
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60733099
115Gastric acid secretion_Homo sapiens_hsa049710.60250330
116HIF-1 signaling pathway_Homo sapiens_hsa040660.59742029
117MAPK signaling pathway_Homo sapiens_hsa040100.59295103
118Circadian rhythm_Homo sapiens_hsa047100.59210440
119Renin secretion_Homo sapiens_hsa049240.58790035
120Gap junction_Homo sapiens_hsa045400.58329858
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57253604
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57102195
123Serotonergic synapse_Homo sapiens_hsa047260.53835862
124Proteoglycans in cancer_Homo sapiens_hsa052050.53609045
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.53553852
126Cocaine addiction_Homo sapiens_hsa050300.53324839
127Tight junction_Homo sapiens_hsa045300.53311671
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53064541
129Melanogenesis_Homo sapiens_hsa049160.52737498
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52482932
131Estrogen signaling pathway_Homo sapiens_hsa049150.52458212
132Long-term depression_Homo sapiens_hsa047300.51939235
133Hepatitis B_Homo sapiens_hsa051610.51871220
134Circadian entrainment_Homo sapiens_hsa047130.51868902
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51839073
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48212380
137Glucagon signaling pathway_Homo sapiens_hsa049220.45236136
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43920261
139Bladder cancer_Homo sapiens_hsa052190.43688914
140cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43498094
141mTOR signaling pathway_Homo sapiens_hsa041500.40586915
142AMPK signaling pathway_Homo sapiens_hsa041520.39212879
143Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38898162
144Inositol phosphate metabolism_Homo sapiens_hsa005620.38607858
145Melanoma_Homo sapiens_hsa052180.38538986
146Selenocompound metabolism_Homo sapiens_hsa004500.38161033
147Insulin signaling pathway_Homo sapiens_hsa049100.37796533
148Histidine metabolism_Homo sapiens_hsa003400.35935491
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35351487
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.32776369
151Primary bile acid biosynthesis_Homo sapiens_hsa001200.32108165
152Pancreatic cancer_Homo sapiens_hsa052120.31461518
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31351949
154Fructose and mannose metabolism_Homo sapiens_hsa000510.30831481
155Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30474134
156N-Glycan biosynthesis_Homo sapiens_hsa005100.28365470
157Fatty acid elongation_Homo sapiens_hsa000620.27605724
158Arginine and proline metabolism_Homo sapiens_hsa003300.27320390
159Folate biosynthesis_Homo sapiens_hsa007900.27149250
160Adherens junction_Homo sapiens_hsa045200.27119070
161Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25937716
162Prostate cancer_Homo sapiens_hsa052150.25197779

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