ARHGAP28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular visceral epithelial cell development (GO:0072015)5.77863957
2glomerular basement membrane development (GO:0032836)5.65325159
3glomerular epithelial cell development (GO:0072310)5.02378285
4paraxial mesoderm development (GO:0048339)4.95597155
5behavioral response to nicotine (GO:0035095)4.26479290
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.22182842
7detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.93377727
8regulation of mesoderm development (GO:2000380)3.81321561
9hippo signaling (GO:0035329)3.80094107
10outer ear morphogenesis (GO:0042473)3.70779659
11tryptophan catabolic process (GO:0006569)3.68689170
12indole-containing compound catabolic process (GO:0042436)3.68689170
13indolalkylamine catabolic process (GO:0046218)3.68689170
14axon extension involved in axon guidance (GO:0048846)3.66556796
15neuron projection extension involved in neuron projection guidance (GO:1902284)3.66556796
16kynurenine metabolic process (GO:0070189)3.65762378
17metanephric mesenchyme development (GO:0072075)3.64059076
18regulation of gene silencing by RNA (GO:0060966)3.63513992
19regulation of posttranscriptional gene silencing (GO:0060147)3.63513992
20regulation of gene silencing by miRNA (GO:0060964)3.63513992
21kidney mesenchyme development (GO:0072074)3.60000500
22neural tube formation (GO:0001841)3.59836595
23indolalkylamine metabolic process (GO:0006586)3.59481367
24regulation of hippo signaling (GO:0035330)3.46240482
25glomerulus development (GO:0032835)3.43455785
26artery development (GO:0060840)3.39220335
27negative regulation of cytosolic calcium ion concentration (GO:0051481)3.38704365
28chondrocyte proliferation (GO:0035988)3.37133571
29negative regulation of DNA repair (GO:0045738)3.34422561
30polarized epithelial cell differentiation (GO:0030859)3.33914050
31kidney morphogenesis (GO:0060993)3.33805492
32regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.33336260
33fucose catabolic process (GO:0019317)3.30744138
34L-fucose metabolic process (GO:0042354)3.30744138
35L-fucose catabolic process (GO:0042355)3.30744138
36planar cell polarity pathway involved in neural tube closure (GO:0090179)3.29157726
37photoreceptor cell maintenance (GO:0045494)3.25800232
38head development (GO:0060322)3.25186745
39behavioral response to ethanol (GO:0048149)3.24118114
40cell proliferation involved in metanephros development (GO:0072203)3.17466974
41protein heterotrimerization (GO:0070208)3.16159212
42regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.15879462
43tryptophan metabolic process (GO:0006568)3.15470721
44regulation of heart morphogenesis (GO:2000826)3.14025251
45renal filtration (GO:0097205)3.13576033
46response to pheromone (GO:0019236)3.13537714
47vascular endothelial growth factor signaling pathway (GO:0038084)3.10046508
48notochord development (GO:0030903)3.06821842
49bone trabecula formation (GO:0060346)3.03403931
50mesenchyme development (GO:0060485)2.99093701
51positive regulation of epithelial to mesenchymal transition (GO:0010718)2.98711826
52reflex (GO:0060004)2.96353732
53regulation of transforming growth factor beta2 production (GO:0032909)2.96004466
54replication fork processing (GO:0031297)2.95875952
55somite rostral/caudal axis specification (GO:0032525)2.95569254
56positive regulation of cell size (GO:0045793)2.94718176
57endocardial cushion development (GO:0003197)2.94273210
58glomerular filtration (GO:0003094)2.94019488
59detection of light stimulus involved in visual perception (GO:0050908)2.93090971
60detection of light stimulus involved in sensory perception (GO:0050962)2.93090971
61negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.92932759
62negative regulation of translation, ncRNA-mediated (GO:0040033)2.92932759
63regulation of translation, ncRNA-mediated (GO:0045974)2.92932759
64collagen fibril organization (GO:0030199)2.91155456
65embryonic foregut morphogenesis (GO:0048617)2.89761155
66cell migration involved in heart development (GO:0060973)2.89535177
67protein K11-linked deubiquitination (GO:0035871)2.88426576
68glucocorticoid receptor signaling pathway (GO:0042921)2.86239777
69mesenchymal cell proliferation (GO:0010463)2.82280819
70nuclear pore complex assembly (GO:0051292)2.80814681
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.80789112
72cilium or flagellum-dependent cell motility (GO:0001539)2.80048581
73nuclear pore organization (GO:0006999)2.79965128
74nonmotile primary cilium assembly (GO:0035058)2.79596159
75inner ear receptor stereocilium organization (GO:0060122)2.78902266
76regulation of meiosis I (GO:0060631)2.78802717
77cilium morphogenesis (GO:0060271)2.78743306
78regulation of sarcomere organization (GO:0060297)2.78439607
79mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.77965820
80establishment of protein localization to Golgi (GO:0072600)2.77522062
81signal peptide processing (GO:0006465)2.76848176
82regulation of SMAD protein import into nucleus (GO:0060390)2.76636062
83regulation of sister chromatid cohesion (GO:0007063)2.76451064
84G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.76117136
85cellular ketone body metabolic process (GO:0046950)2.75314302
86piRNA metabolic process (GO:0034587)2.75170629
87pre-miRNA processing (GO:0031054)2.74993437
88mitotic chromosome condensation (GO:0007076)2.73736428
89regulation of mitotic spindle organization (GO:0060236)2.73643546
90mitotic metaphase plate congression (GO:0007080)2.72763909
91protein localization to kinetochore (GO:0034501)2.72414726
92epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72315501
93regulation of spindle organization (GO:0090224)2.72286710
94organ induction (GO:0001759)2.71792686
95detection of mechanical stimulus involved in sensory perception (GO:0050974)2.71342809
96sulfation (GO:0051923)2.70546201
97axoneme assembly (GO:0035082)2.70007749
98regulation of stem cell maintenance (GO:2000036)2.69900347
99regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.69547343
100protein polyglutamylation (GO:0018095)2.68888483
101embryonic cranial skeleton morphogenesis (GO:0048701)2.68600254
102embryonic forelimb morphogenesis (GO:0035115)2.68153179
103proximal/distal pattern formation (GO:0009954)2.66259191
104mesodermal cell differentiation (GO:0048333)2.66075347
105lymphangiogenesis (GO:0001946)2.64850227
106regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.63906927
107negative regulation of cell fate specification (GO:0009996)2.63410859
108midgut development (GO:0007494)2.63345772
109limb bud formation (GO:0060174)2.62521402
110endoderm formation (GO:0001706)2.62388100
111epithelial cilium movement (GO:0003351)2.61051963
112transmission of nerve impulse (GO:0019226)2.59983882
113negative regulation of axon guidance (GO:1902668)2.59710045
114embryonic pattern specification (GO:0009880)2.59627194
115dorsal/ventral axis specification (GO:0009950)2.59397493
116DNA double-strand break processing (GO:0000729)2.58946029
117negative regulation of chondrocyte differentiation (GO:0032331)2.58825132
118positive regulation of SMAD protein import into nucleus (GO:0060391)2.58814241
119mesenchymal-epithelial cell signaling (GO:0060638)2.58246919
120muscle cell fate commitment (GO:0042693)2.57897527
121branching involved in prostate gland morphogenesis (GO:0060442)2.57849226
122sequestering of extracellular ligand from receptor (GO:0035581)2.57432172
123reciprocal DNA recombination (GO:0035825)2.57375911
124reciprocal meiotic recombination (GO:0007131)2.57375911
125neuronal action potential (GO:0019228)2.57008101
126hindlimb morphogenesis (GO:0035137)2.56982051
127tachykinin receptor signaling pathway (GO:0007217)2.56801823
128craniofacial suture morphogenesis (GO:0097094)2.56172586
129body morphogenesis (GO:0010171)2.56163964
130gamma-aminobutyric acid transport (GO:0015812)2.55698028
131positive regulation of catenin import into nucleus (GO:0035413)2.54745877
132embryonic axis specification (GO:0000578)2.53760280
133metaphase plate congression (GO:0051310)2.53410327
134mitotic sister chromatid cohesion (GO:0007064)2.53100557
135cilium organization (GO:0044782)2.52450109
136embryonic camera-type eye development (GO:0031076)2.52244601
137neural crest cell development (GO:0014032)2.51857044
138negative regulation of systemic arterial blood pressure (GO:0003085)2.51474147
139establishment of apical/basal cell polarity (GO:0035089)2.51350506
140negative regulation of embryonic development (GO:0045992)2.51300682
141negative regulation of activin receptor signaling pathway (GO:0032926)2.50853486
142cellular response to sterol (GO:0036315)2.50664222
143embryonic hindlimb morphogenesis (GO:0035116)2.50383038
144embryonic skeletal joint morphogenesis (GO:0060272)2.49236671
145rRNA catabolic process (GO:0016075)2.48764710
146ketone body metabolic process (GO:1902224)2.48338725
147cilium assembly (GO:0042384)2.48326318
148indole-containing compound metabolic process (GO:0042430)2.47747789
149regulation of non-canonical Wnt signaling pathway (GO:2000050)2.46677393
150lymph vessel development (GO:0001945)2.45724949
151sperm motility (GO:0030317)2.45645151
152prenylation (GO:0097354)2.45184306
153protein prenylation (GO:0018342)2.45184306
154positive regulation of mesenchymal cell proliferation (GO:0002053)2.45079168
155auditory receptor cell stereocilium organization (GO:0060088)2.44571069
156negative regulation of axon extension involved in axon guidance (GO:0048843)2.44477202
157lung-associated mesenchyme development (GO:0060484)2.42962075
158insulin-like growth factor receptor signaling pathway (GO:0048009)2.42833157
159corticosteroid receptor signaling pathway (GO:0031958)2.42445895
160retinal cone cell development (GO:0046549)2.42076384
161embryonic epithelial tube formation (GO:0001838)2.41109119
162forelimb morphogenesis (GO:0035136)2.40819601
163regulation of action potential (GO:0098900)2.40592742
164DNA integration (GO:0015074)2.39832479
165cornea development in camera-type eye (GO:0061303)2.39736180
166regulation of organ formation (GO:0003156)2.39688467
167establishment of monopolar cell polarity (GO:0061162)2.39503313
168establishment or maintenance of monopolar cell polarity (GO:0061339)2.39503313
169cartilage morphogenesis (GO:0060536)2.39404157
170L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.39207804
171basement membrane organization (GO:0071711)2.37995463
172mitotic nuclear envelope disassembly (GO:0007077)2.37887867
173limb development (GO:0060173)2.37774798
174appendage development (GO:0048736)2.37774798
175organ formation (GO:0048645)2.37233154
176atrial cardiac muscle cell action potential (GO:0086014)2.36879768
177spinal cord motor neuron differentiation (GO:0021522)2.36651719
178positive regulation of gastrulation (GO:2000543)2.35999720
179myoblast migration (GO:0051451)2.35620678
180monoubiquitinated protein deubiquitination (GO:0035520)2.35266021
181amine catabolic process (GO:0009310)2.35141020
182cellular biogenic amine catabolic process (GO:0042402)2.35141020
183muscle cell migration (GO:0014812)2.35036057
184middle ear morphogenesis (GO:0042474)2.34895934
185centriole replication (GO:0007099)2.34305796
186protein K48-linked deubiquitination (GO:0071108)2.34136656
187cell proliferation involved in kidney development (GO:0072111)2.33987425
188epithelial tube formation (GO:0072175)2.33375481
189regulation of mesenchymal cell proliferation (GO:0010464)2.32488903
190cell migration involved in sprouting angiogenesis (GO:0002042)2.32065905
191recombinational repair (GO:0000725)2.32058157
192somite development (GO:0061053)2.31801936
193double-strand break repair via homologous recombination (GO:0000724)2.31648834
194protein localization to cilium (GO:0061512)2.31002392
195regulation of nuclear cell cycle DNA replication (GO:0033262)2.30283332
196cilium movement (GO:0003341)2.28810178

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.64418721
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.52855134
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.92015189
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.87643057
5GBX2_23144817_ChIP-Seq_PC3_Human3.34782403
6VDR_22108803_ChIP-Seq_LS180_Human3.25556662
7ZNF274_21170338_ChIP-Seq_K562_Hela3.15829710
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.06828215
9AR_21909140_ChIP-Seq_LNCAP_Human2.93617583
10EZH2_22144423_ChIP-Seq_EOC_Human2.91548209
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.82647962
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.82344553
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.81152624
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.79946242
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.78174261
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.72733969
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.66613594
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65775677
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60382067
20IGF1R_20145208_ChIP-Seq_DFB_Human2.54445278
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49885219
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46142222
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.36945540
24FUS_26573619_Chip-Seq_HEK293_Human2.36116688
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.31782525
26TP63_17297297_ChIP-ChIP_HaCaT_Human2.28684819
27* P300_19829295_ChIP-Seq_ESCs_Human2.28262331
28TAF15_26573619_Chip-Seq_HEK293_Human2.26270806
29FLI1_27457419_Chip-Seq_LIVER_Mouse2.21762163
30CLOCK_20551151_ChIP-Seq_293T_Human2.17195761
31RARG_19884340_ChIP-ChIP_MEFs_Mouse2.16116240
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.15450268
33EWS_26573619_Chip-Seq_HEK293_Human2.14146738
34MYC_18555785_ChIP-Seq_MESCs_Mouse2.08970368
35* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.04898332
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.02947564
37TRIM28_21343339_ChIP-Seq_HEK293_Human2.01887988
38CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01034769
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.98494335
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.90916002
41BRD4_25478319_ChIP-Seq_HGPS_Human1.89403385
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.88187064
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87669018
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.86468212
45* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85371316
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.82553153
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81801870
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77628215
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77306796
50SMAD4_21799915_ChIP-Seq_A2780_Human1.76130331
51* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.74580223
52ER_23166858_ChIP-Seq_MCF-7_Human1.73884945
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.73497946
54KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71516112
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71516112
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71516112
57STAT3_23295773_ChIP-Seq_U87_Human1.71429095
58TCF3_18692474_ChIP-Seq_MEFs_Mouse1.71222551
59SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.70650702
60* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.70098204
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69620719
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69140420
63* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.67573415
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66486087
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.66486087
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65749357
67BCAT_22108803_ChIP-Seq_LS180_Human1.63864237
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.63850467
69* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61221672
70* CBP_20019798_ChIP-Seq_JUKART_Human1.61221672
71CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.61141489
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.59694269
73FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.59605465
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.58786425
75* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.56252105
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55981595
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55594523
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53900295
79* TCF4_23295773_ChIP-Seq_U87_Human1.53645243
80ESR1_21235772_ChIP-Seq_MCF-7_Human1.53594270
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53438989
82* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51718616
83AR_25329375_ChIP-Seq_VCAP_Human1.50896103
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.49799748
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48889399
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.47998853
87AR_21572438_ChIP-Seq_LNCaP_Human1.47853847
88ELK3_25401928_ChIP-Seq_HUVEC_Human1.46419620
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44676713
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.44385841
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.43248141
92* NANOG_21062744_ChIP-ChIP_HESCs_Human1.43006125
93ISL1_27105846_Chip-Seq_CPCs_Mouse1.42697016
94TCF4_22108803_ChIP-Seq_LS180_Human1.40978044
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39408516
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39172181
97RUNX2_22187159_ChIP-Seq_PCA_Human1.37498750
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37437569
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.37158030
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.36563449
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36133346
102BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35391681
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34929223
104* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33836621
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32869350
106* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32091397
107TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31961276
108ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31939035
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31843307
110MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.31601362
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31299976
112RNF2_27304074_Chip-Seq_NSC_Mouse1.30236171
113* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29506560
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29450015
115SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29450015
116* SOX2_19829295_ChIP-Seq_ESCs_Human1.27477957
117* NANOG_19829295_ChIP-Seq_ESCs_Human1.27477957
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.26590091
119* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26306182
120NFE2_27457419_Chip-Seq_LIVER_Mouse1.25907815
121PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24686822
122CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24584997
123IRF1_19129219_ChIP-ChIP_H3396_Human1.24028418
124NANOG_18555785_Chip-Seq_ESCs_Mouse1.22034665
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20840223
126TCF3_18692474_ChIP-Seq_MESCs_Mouse1.19825742
127NANOG_16153702_ChIP-ChIP_HESCs_Human1.19705873
128SMAD3_21741376_ChIP-Seq_HESCs_Human1.19345822
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.18756420
130TP53_22573176_ChIP-Seq_HFKS_Human1.17851972
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17790147
132MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17562287
133ESR1_20079471_ChIP-ChIP_T-47D_Human1.17555819
134SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17409661
135XRN2_22483619_ChIP-Seq_HELA_Human1.16288458
136CJUN_26792858_Chip-Seq_BT549_Human1.15872117
137POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15656116
138PRDM14_20953172_ChIP-Seq_ESCs_Human1.14770295
139UBF1/2_26484160_Chip-Seq_HMECs_Human1.14322313
140SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13295995
141* SMAD4_21741376_ChIP-Seq_HESCs_Human1.13088854
142* TP53_20018659_ChIP-ChIP_R1E_Mouse1.13000984
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12872099
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12362510
145* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12030355
146EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11678773
147KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11626523
148DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10841775
149CHD1_26751641_Chip-Seq_LNCaP_Human1.10323587
150MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09911667
151P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09824920
152* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09599619
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09273111
154CDX2_22108803_ChIP-Seq_LS180_Human1.08866734
155CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08661550
156* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08590334
157EZH2_27304074_Chip-Seq_ESCs_Mouse1.07936344
158GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07639674
159TCF4_18268006_ChIP-ChIP_LS174T_Human1.07496849
160CRX_20693478_ChIP-Seq_RETINA_Mouse1.07216721
161EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06472553
162ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05951802
163KDM2B_26808549_Chip-Seq_REH_Human1.05686869
164NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05123094
165* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05037072
166EED_16625203_ChIP-ChIP_MESCs_Mouse1.04692348
167SOX2_21211035_ChIP-Seq_LN229_Gbm1.04632849
168P53_22387025_ChIP-Seq_ESCs_Mouse1.04402658
169HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04148910
170PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03823919
171* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03372988
172TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03135856
173* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03053183
174PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02740982
175CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02593077
176GATA4_21415370_ChIP-Seq_HL-1_Mouse1.01728664
177E2F1_18555785_Chip-Seq_ESCs_Mouse1.01407913
178TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01038940
179* SMAD3_21741376_ChIP-Seq_ESCs_Human1.01025307
180ATF3_27146783_Chip-Seq_COLON_Human1.00983344
181* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.00214241
182SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99649704
183CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99535876
184FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98935757
185FOXA1_25329375_ChIP-Seq_VCAP_Human0.98935757
186TP53_16413492_ChIP-PET_HCT116_Human0.97869547
187REST_21632747_ChIP-Seq_MESCs_Mouse0.97394168
188SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96901466
189ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96722540
190ARNT_22903824_ChIP-Seq_MCF-7_Human0.96527205
191SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96190739
192* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95981469
193ESR2_21235772_ChIP-Seq_MCF-7_Human0.94288949
194MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93815852
195PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93148008

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.46841263
2MP0008438_abnormal_cutaneous_collagen3.11818720
3MP0003123_paternal_imprinting2.99863611
4MP0003890_abnormal_embryonic-extraembry2.92786048
5MP0005503_abnormal_tendon_morphology2.87000550
6MP0003122_maternal_imprinting2.82848363
7MP0003705_abnormal_hypodermis_morpholog2.77152455
8MP0004272_abnormal_basement_membrane2.73540464
9MP0000537_abnormal_urethra_morphology2.71537685
10MP0002102_abnormal_ear_morphology2.65651039
11MP0005623_abnormal_meninges_morphology2.65581603
12MP0010368_abnormal_lymphatic_system2.58761212
13MP0003385_abnormal_body_wall2.47991351
14MP0003195_calcinosis2.47274353
15MP0009053_abnormal_anal_canal2.46654651
16MP0000569_abnormal_digit_pigmentation2.30558423
17MP0003942_abnormal_urinary_system2.28674226
18MP0003121_genomic_imprinting2.27654652
19MP0003646_muscle_fatigue2.23604063
20MP0008877_abnormal_DNA_methylation2.15882780
21MP0003136_yellow_coat_color2.11782836
22MP0003937_abnormal_limbs/digits/tail_de2.08751315
23MP0005551_abnormal_eye_electrophysiolog2.08217409
24MP0001968_abnormal_touch/_nociception2.06141395
25MP0001879_abnormal_lymphatic_vessel2.04322157
26MP0009250_abnormal_appendicular_skeleto2.01373305
27MP0000534_abnormal_ureter_morphology1.96977650
28MP0004133_heterotaxia1.91760456
29MP0002736_abnormal_nociception_after1.85516565
30MP0006054_spinal_hemorrhage1.81773126
31MP0002249_abnormal_larynx_morphology1.80151271
32MP0006276_abnormal_autonomic_nervous1.79570975
33MP0002932_abnormal_joint_morphology1.77690932
34MP0006292_abnormal_olfactory_placode1.74950856
35MP0003941_abnormal_skin_development1.73536098
36MP0002282_abnormal_trachea_morphology1.72843587
37MP0005275_abnormal_skin_tensile1.71739225
38MP0004145_abnormal_muscle_electrophysio1.71717072
39MP0000733_abnormal_muscle_development1.68502271
40MP0004147_increased_porphyrin_level1.65823368
41MP0003567_abnormal_fetal_cardiomyocyte1.65666364
42MP0002837_dystrophic_cardiac_calcinosis1.64042137
43MP0003279_aneurysm1.60952990
44MP0009046_muscle_twitch1.60925608
45MP0005508_abnormal_skeleton_morphology1.55150380
46MP0000767_abnormal_smooth_muscle1.53478925
47MP0006072_abnormal_retinal_apoptosis1.52277307
48MP0005253_abnormal_eye_physiology1.51524644
49MP0010352_gastrointestinal_tract_polyps1.51233161
50MP0000049_abnormal_middle_ear1.49878986
51MP0001485_abnormal_pinna_reflex1.49582232
52MP0000372_irregular_coat_pigmentation1.47910240
53MP0003935_abnormal_craniofacial_develop1.47372252
54MP0003115_abnormal_respiratory_system1.46957718
55MP0008057_abnormal_DNA_replication1.44670679
56MP0002735_abnormal_chemical_nociception1.39171829
57MP0003755_abnormal_palate_morphology1.38547710
58MP0003787_abnormal_imprinting1.37744775
59MP0009384_cardiac_valve_regurgitation1.37469964
60MP0000427_abnormal_hair_cycle1.36992659
61MP0000428_abnormal_craniofacial_morphol1.36084803
62MP0000516_abnormal_urinary_system1.35998417
63MP0005367_renal/urinary_system_phenotyp1.35998417
64MP0002938_white_spotting1.35749909
65MP0003077_abnormal_cell_cycle1.35526200
66MP0001486_abnormal_startle_reflex1.33732504
67MP0003878_abnormal_ear_physiology1.33348061
68MP0005377_hearing/vestibular/ear_phenot1.33348061
69MP0000631_abnormal_neuroendocrine_gland1.32428271
70MP0008932_abnormal_embryonic_tissue1.31593996
71MP0002085_abnormal_embryonic_tissue1.30993527
72MP0002084_abnormal_developmental_patter1.30364101
73MP0005187_abnormal_penis_morphology1.30328080
74MP0001984_abnormal_olfaction1.30146334
75MP0004197_abnormal_fetal_growth/weight/1.29713311
76MP0003693_abnormal_embryo_hatching1.27869329
77MP0001501_abnormal_sleep_pattern1.27708836
78MP0004957_abnormal_blastocyst_morpholog1.27441909
79MP0005646_abnormal_pituitary_gland1.27276898
80MP0005410_abnormal_fertilization1.25597407
81MP0003315_abnormal_perineum_morphology1.25541711
82MP0001915_intracranial_hemorrhage1.25122206
83MP0008872_abnormal_physiological_respon1.24073662
84MP0002138_abnormal_hepatobiliary_system1.23427795
85MP0002109_abnormal_limb_morphology1.22937941
86MP0002638_abnormal_pupillary_reflex1.22457029
87MP0009745_abnormal_behavioral_response1.22354152
88MP0003718_maternal_effect1.21335133
89MP0001697_abnormal_embryo_size1.20896391
90MP0003566_abnormal_cell_adhesion1.20313351
91MP0003880_abnormal_central_pattern1.17878262
92MP0004142_abnormal_muscle_tone1.17765600
93MP0004084_abnormal_cardiac_muscle1.17599388
94MP0003119_abnormal_digestive_system1.17589935
95MP0005380_embryogenesis_phenotype1.17294205
96MP0001672_abnormal_embryogenesis/_devel1.17294205
97MP0001986_abnormal_taste_sensitivity1.16497541
98MP0002272_abnormal_nervous_system1.15938582
99MP0002234_abnormal_pharynx_morphology1.15782743
100MP0000350_abnormal_cell_proliferation1.15200730
101MP0002925_abnormal_cardiovascular_devel1.15090743
102MP0002088_abnormal_embryonic_growth/wei1.14229361
103MP0003984_embryonic_growth_retardation1.13367520
104MP0005645_abnormal_hypothalamus_physiol1.12785177
105MP0002116_abnormal_craniofacial_bone1.11909109
106MP0002233_abnormal_nose_morphology1.11675907
107MP0004043_abnormal_pH_regulation1.11641527
108MP0001293_anophthalmia1.11580134
109MP0002557_abnormal_social/conspecific_i1.11386520
110MP0002086_abnormal_extraembryonic_tissu1.10938347
111MP0005076_abnormal_cell_differentiation1.10897818
112MP0000383_abnormal_hair_follicle1.10305180
113MP0001299_abnormal_eye_distance/1.09765340
114MP0004233_abnormal_muscle_weight1.09640225
115MP0004215_abnormal_myocardial_fiber1.09453943
116MP0004885_abnormal_endolymph1.09095832
117MP0002114_abnormal_axial_skeleton1.07465782
118MP0003091_abnormal_cell_migration1.07176140
119MP0008007_abnormal_cellular_replicative1.07168820
120MP0001270_distended_abdomen1.07142473
121MP0005023_abnormal_wound_healing1.07141422
122MP0010094_abnormal_chromosome_stability1.06895240
123MP0000432_abnormal_head_morphology1.06692820
124MP0003950_abnormal_plasma_membrane1.06191717
125MP0003137_abnormal_impulse_conducting1.05986940
126MP0000163_abnormal_cartilage_morphology1.04858417
127MP0001730_embryonic_growth_arrest1.04172864
128MP0003111_abnormal_nucleus_morphology1.03374590
129MP0002115_abnormal_skeleton_extremities1.01237655
130MP0003698_abnormal_male_reproductive1.01213947
131MP0004085_abnormal_heartbeat1.01091871
132MP0002113_abnormal_skeleton_development1.00326290
133MP0000778_abnormal_nervous_system0.99048490
134MP0002160_abnormal_reproductive_system0.98414936
135MP0002752_abnormal_somatic_nervous0.97411635
136MP0002111_abnormal_tail_morphology0.97280248
137MP0002163_abnormal_gland_morphology0.97025506
138MP0002572_abnormal_emotion/affect_behav0.96826858
139MP0001849_ear_inflammation0.96679173
140MP0001614_abnormal_blood_vessel0.96548883
141MP0002928_abnormal_bile_duct0.94257473
142MP0005174_abnormal_tail_pigmentation0.94211946
143MP0002733_abnormal_thermal_nociception0.93186862
144MP0005195_abnormal_posterior_eye0.92560398
145MP0010386_abnormal_urinary_bladder0.91779438
146MP0002184_abnormal_innervation0.91730947
147MP0006138_congestive_heart_failure0.91036047
148MP0000566_synostosis0.91011708
149MP0002067_abnormal_sensory_capabilities0.90863461
150MP0001286_abnormal_eye_development0.90745838
151MP0005248_abnormal_Harderian_gland0.90725720
152MP0003283_abnormal_digestive_organ0.90676461
153MP0001970_abnormal_pain_threshold0.89821296
154MP0002128_abnormal_blood_circulation0.89109570
155MP0000762_abnormal_tongue_morphology0.88649051
156MP0001529_abnormal_vocalization0.88462931
157MP0005391_vision/eye_phenotype0.88068981
158MP0002177_abnormal_outer_ear0.87714020
159MP0005084_abnormal_gallbladder_morpholo0.87674800
160MP0001346_abnormal_lacrimal_gland0.87622047
161MP0002751_abnormal_autonomic_nervous0.87514694
162MP0000026_abnormal_inner_ear0.87123412
163MP0004924_abnormal_behavior0.86775413
164MP0005386_behavior/neurological_phenoty0.86775413
165MP0002108_abnormal_muscle_morphology0.86340232
166MP0000230_abnormal_systemic_arterial0.84475716
167MP0001929_abnormal_gametogenesis0.84280593
168MP0005167_abnormal_blood-brain_barrier0.83688142
169MP0005389_reproductive_system_phenotype0.82041188
170MP0001175_abnormal_lung_morphology0.81877121
171MP0000266_abnormal_heart_morphology0.81873735
172MP0005171_absent_coat_pigmentation0.81521475
173MP0002080_prenatal_lethality0.80984597
174MP0005197_abnormal_uvea_morphology0.80560540
175MP0010630_abnormal_cardiac_muscle0.79209319
176MP0002009_preneoplasia0.77703481
177MP0002653_abnormal_ependyma_morphology0.77512818

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.36211555
2Protrusio acetabuli (HP:0003179)4.25460124
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.21129334
4Short 4th metacarpal (HP:0010044)4.21129334
5Pancreatic fibrosis (HP:0100732)3.92295052
6True hermaphroditism (HP:0010459)3.67836630
7Shallow orbits (HP:0000586)3.60763694
8Molar tooth sign on MRI (HP:0002419)3.44166811
9Abnormality of midbrain morphology (HP:0002418)3.44166811
10Ankle contracture (HP:0006466)3.41138116
11Abnormality of the 4th metacarpal (HP:0010012)3.35843220
12Nephronophthisis (HP:0000090)3.32634156
13Chronic hepatic failure (HP:0100626)3.28637210
14Renal duplication (HP:0000075)3.14138115
15Attenuation of retinal blood vessels (HP:0007843)3.08943485
16Hyperventilation (HP:0002883)3.07033395
17Abnormality of the renal cortex (HP:0011035)3.02246174
18Abnormality of the renal medulla (HP:0100957)3.02071766
19Congenital stationary night blindness (HP:0007642)3.00766313
20Genetic anticipation (HP:0003743)2.98976674
21Aplasia/Hypoplasia of the tibia (HP:0005772)2.92116800
22Premature rupture of membranes (HP:0001788)2.88757483
23Mesangial abnormality (HP:0001966)2.88179159
24Keratoconus (HP:0000563)2.80554734
25Increased corneal curvature (HP:0100692)2.80554734
26Cystic liver disease (HP:0006706)2.76977600
27Medial flaring of the eyebrow (HP:0010747)2.73970409
28Aortic aneurysm (HP:0004942)2.73753420
29Asymmetry of the thorax (HP:0001555)2.72097733
30Tubular atrophy (HP:0000092)2.71278197
31Gaze-evoked nystagmus (HP:0000640)2.64423998
32Diastasis recti (HP:0001540)2.61520205
33Genital tract atresia (HP:0001827)2.58806726
34Aortic dissection (HP:0002647)2.55852653
35Abnormality of alanine metabolism (HP:0010916)2.54237737
36Hyperalaninemia (HP:0003348)2.54237737
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54237737
38Vaginal atresia (HP:0000148)2.52058356
39Progressive inability to walk (HP:0002505)2.48684997
40Broad metatarsal (HP:0001783)2.48064420
41Wrist flexion contracture (HP:0001239)2.45760442
42Abolished electroretinogram (ERG) (HP:0000550)2.45279709
43Camptodactyly of toe (HP:0001836)2.42511878
44Midline defect of the nose (HP:0004122)2.42011703
45Inability to walk (HP:0002540)2.39769274
46Abnormality of the ischium (HP:0003174)2.39421894
47Intestinal atresia (HP:0011100)2.38430511
48Progressive cerebellar ataxia (HP:0002073)2.37789555
49Shawl scrotum (HP:0000049)2.36809188
50Syringomyelia (HP:0003396)2.36329863
51Spinal cord lesions (HP:0100561)2.36329863
52Broad toe (HP:0001837)2.36311994
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.35564707
54Focal segmental glomerulosclerosis (HP:0000097)2.32384820
55Abnormal pancreas size (HP:0012094)2.31615692
56Anencephaly (HP:0002323)2.30491556
57Abnormality of the labia minora (HP:0012880)2.29920152
58Abnormality of the phalanges of the hallux (HP:0010057)2.29515791
59Sclerocornea (HP:0000647)2.29368958
60Lymphangioma (HP:0100764)2.29084553
61Type II lissencephaly (HP:0007260)2.28542529
62Gait imbalance (HP:0002141)2.28328564
63Bony spicule pigmentary retinopathy (HP:0007737)2.26584107
64Congenital hepatic fibrosis (HP:0002612)2.24182119
65Bladder diverticulum (HP:0000015)2.22092317
66Congenital primary aphakia (HP:0007707)2.21629341
67Abnormality of dentin (HP:0010299)2.21055831
68Protruding tongue (HP:0010808)2.20651005
69Bile duct proliferation (HP:0001408)2.20127730
70Abnormal biliary tract physiology (HP:0012439)2.20127730
71Polydipsia (HP:0001959)2.20114939
72Abnormal drinking behavior (HP:0030082)2.20114939
73Mesomelia (HP:0003027)2.19507424
74Chin dimple (HP:0010751)2.19172474
75Pendular nystagmus (HP:0012043)2.18641553
76Knee flexion contracture (HP:0006380)2.17702582
77Hepatoblastoma (HP:0002884)2.17450978
78Metaphyseal dysplasia (HP:0100255)2.15066145
79Broad thumb (HP:0011304)2.14518354
80Deviation of the hallux (HP:0010051)2.14043615
81Cerebellar dysplasia (HP:0007033)2.13812975
82Microglossia (HP:0000171)2.12391128
83Absent phalangeal crease (HP:0006109)2.10797324
84Hip contracture (HP:0003273)2.10768647
85Soft skin (HP:0000977)2.10214553
86Hypoplastic ischia (HP:0003175)2.10182010
87Cervical subluxation (HP:0003308)2.05867984
88Short middle phalanx of the 5th finger (HP:0004220)2.05039095
89Colon cancer (HP:0003003)2.04689111
90Cerebral aneurysm (HP:0004944)2.04564610
91Selective tooth agenesis (HP:0001592)2.03930300
92Nephrogenic diabetes insipidus (HP:0009806)2.03662224
93Small hand (HP:0200055)2.03488437
94Postaxial foot polydactyly (HP:0001830)2.03371876
95Coronal craniosynostosis (HP:0004440)2.01979378
96Hypoalbuminemia (HP:0003073)2.00495197
97Abnormal albumin level (HP:0012116)2.00495197
98Chorioretinal atrophy (HP:0000533)2.00097914
99Abnormality of the distal phalanx of the thumb (HP:0009617)1.99543715
100Optic nerve hypoplasia (HP:0000609)1.99513682
101Short 5th finger (HP:0009237)1.98792974
102Bilateral microphthalmos (HP:0007633)1.98407127
103Mitral valve prolapse (HP:0001634)1.98192408
104Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97844221
105Flexion contracture of toe (HP:0005830)1.97618606
106Joint contractures involving the joints of the feet (HP:0100492)1.97618606
107Broad long bones (HP:0005622)1.97526760
108Calcaneovalgus deformity (HP:0001848)1.96297417
109Renal cortical cysts (HP:0000803)1.95038300
110Type 1 muscle fiber predominance (HP:0003803)1.94915878
111Enlarged penis (HP:0000040)1.92642386
112Male pseudohermaphroditism (HP:0000037)1.92612478
113Hallux valgus (HP:0001822)1.92353634
114Thyroid-stimulating hormone excess (HP:0002925)1.91893453
115Broad phalanges of the hand (HP:0009768)1.91670426
116Embryonal renal neoplasm (HP:0011794)1.91583122
117Occipital encephalocele (HP:0002085)1.90875290
118Abnormality of the 2nd finger (HP:0004100)1.90711999
119Broad phalanx (HP:0006009)1.90115082
120Short tibia (HP:0005736)1.90054949
121Anophthalmia (HP:0000528)1.90036311
122Cutaneous finger syndactyly (HP:0010554)1.88737343
123Buphthalmos (HP:0000557)1.88686114
124Abnormal rod and cone electroretinograms (HP:0008323)1.88527390
125Broad finger (HP:0001500)1.88041184
126Lissencephaly (HP:0001339)1.87851000
127Deformed tarsal bones (HP:0008119)1.87843900
128Rectal prolapse (HP:0002035)1.87094682
129Polyuria (HP:0000103)1.86957346
130Nephroblastoma (Wilms tumor) (HP:0002667)1.86632052
131Abnormality of the pubic bones (HP:0003172)1.86576758
132Trigonocephaly (HP:0000243)1.86049829
133Aplasia/Hypoplasia of the uvula (HP:0010293)1.85921604
134Broad hallux (HP:0010055)1.85549890
135Dandy-Walker malformation (HP:0001305)1.84289915
136Furrowed tongue (HP:0000221)1.84177367
137Broad-based gait (HP:0002136)1.83659323
138Bulbous nose (HP:0000414)1.82899385
139Broad palm (HP:0001169)1.82875694
140Abnormality of the parietal bone (HP:0002696)1.82549610
141Limited hip movement (HP:0008800)1.82540487
142Decreased central vision (HP:0007663)1.82325369
143Bifid tongue (HP:0010297)1.82232565
144Supernumerary spleens (HP:0009799)1.82175554
145Bowel diverticulosis (HP:0005222)1.82064139
146Congenital sensorineural hearing impairment (HP:0008527)1.81664497
147Exostoses (HP:0100777)1.81622438
148Abnormality of the calcaneus (HP:0008364)1.81276612
149Wormian bones (HP:0002645)1.80656155
150Atresia of the external auditory canal (HP:0000413)1.80468112
151Preaxial hand polydactyly (HP:0001177)1.79087540
152Decreased circulating renin level (HP:0003351)1.78734910
153Poor coordination (HP:0002370)1.77455504
154Febrile seizures (HP:0002373)1.77068017
155Short foot (HP:0001773)1.76920407
156Large for gestational age (HP:0001520)1.76072467
157Abnormality of macular pigmentation (HP:0008002)1.75459738
158Pterygium (HP:0001059)1.74682969
159Postaxial hand polydactyly (HP:0001162)1.74403836
160Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.74301707
161Dilatation of the ascending aorta (HP:0005111)1.74093883
162Wide anterior fontanel (HP:0000260)1.72674068
163Astigmatism (HP:0000483)1.72632008
164Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.72402294
165Spinal rigidity (HP:0003306)1.72131023
166Renal hypoplasia (HP:0000089)1.71076873
167Narrow forehead (HP:0000341)1.71041317
168Glomerulosclerosis (HP:0000096)1.70911952
169Subacute progressive viral hepatitis (HP:0006572)1.70837047
170Preaxial foot polydactyly (HP:0001841)1.70435403
171Absent speech (HP:0001344)1.69661715
172Aplasia of the musculature (HP:0100854)1.69569927
173Fair hair (HP:0002286)1.69187220
174Dynein arm defect of respiratory motile cilia (HP:0012255)1.68846531
175Absent/shortened dynein arms (HP:0200106)1.68846531
176Hypoplasia of the pons (HP:0012110)1.68629995
177Scotoma (HP:0000575)1.68629162
178Cutaneous syndactyly (HP:0012725)1.68185957
179Hematochezia (HP:0002573)1.67821188
180Aplasia/Hypoplasia of the patella (HP:0006498)1.67722773
181Down-sloping shoulders (HP:0200021)1.67624054
182Deviation of the thumb (HP:0009603)1.67192299
183Distal arthrogryposis (HP:0005684)1.67119939
184Patellar aplasia (HP:0006443)1.66727734
185Abnormal finger flexion creases (HP:0006143)1.66558848
186Tarsal synostosis (HP:0008368)1.66148379
187Abnormality of the radial head (HP:0003995)1.64370066
188Vascular tortuosity (HP:0004948)1.62400846
189Blue sclerae (HP:0000592)1.60616001
190Aneurysm (HP:0002617)1.60048216
191Abnormality of the peritoneum (HP:0002585)1.59468462
192Abnormal lung lobation (HP:0002101)1.58322273

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.31907106
2LATS14.16964141
3LATS23.96699126
4BMPR1B3.56911446
5ADRBK22.73143612
6EPHB22.68021131
7TGFBR12.59448486
8CDC72.53489048
9TNIK2.52616474
10PDGFRA2.51564151
11WNK32.48289734
12DDR22.42419056
13TRIB32.26004877
14STK38L2.25589743
15TIE12.22958088
16INSRR2.15308424
17CASK2.15251885
18NUAK12.12480711
19MAP4K22.08193640
20PKN22.02086923
21PAK41.98004424
22GRK11.97155133
23STK31.97068199
24ZAK1.96299685
25EPHA31.78754667
26MOS1.74849830
27CDK121.66813573
28TTN1.64281988
29MAP3K41.62651731
30PINK11.60101998
31RIPK11.57298001
32MKNK11.55386305
33KDR1.52203158
34TRIM281.50163580
35PLK41.48298989
36NEK91.48280944
37MAPK131.48030011
38TTK1.47412413
39OXSR11.46301122
40AKT31.44905097
41PTK61.43103421
42NEK21.40400567
43WNK41.33720478
44FER1.33007715
45STK391.30842113
46PAK21.29516779
47EEF2K1.28073721
48CDK81.27265533
49MAP3K101.25427974
50LRRK21.22933988
51ADRBK11.19008387
52MAP3K81.16068447
53NEK11.15374621
54MTOR1.14557805
55OBSCN1.14443994
56MARK11.14399403
57LIMK11.14125523
58TGFBR21.13613335
59FGFR11.11888249
60PTK21.11434247
61RPS6KB21.09998769
62DAPK21.09673046
63NLK1.04881469
64PNCK1.03039311
65PLK31.01979709
66CDK71.01803172
67PRKCE0.99820176
68PLK10.99810720
69TAOK30.98910521
70KSR20.96342685
71CHEK20.95658471
72STK100.93897003
73PLK20.93828610
74BUB10.93402427
75PDGFRB0.92643728
76BCR0.91272014
77MAP2K70.90897034
78RET0.90794512
79PIK3CG0.90739532
80PRKCG0.90083455
81RPS6KA40.88393521
82TSSK60.88352052
83CDK60.83053465
84WEE10.80749773
85PAK30.80748478
86SCYL20.80215148
87AURKB0.79710717
88PRKD30.79084034
89NTRK10.79063874
90NTRK30.77820689
91ERBB40.75379672
92MYLK0.75019658
93FLT30.74254459
94ILK0.71957199
95EPHA40.71529623
96BRSK20.71415608
97ERBB30.70584948
98ROCK10.70035202
99MELK0.68820740
100TLK10.68646674
101SIK10.67523069
102CAMK1G0.66970807
103JAK30.65460479
104PAK10.65369947
105MAP2K10.65137735
106EIF2AK30.65125456
107PASK0.64242551
108CSNK1G20.62589889
109FGFR20.60809043
110ERBB20.60422758
111VRK10.60229996
112ATR0.59842136
113TESK10.59839432
114MKNK20.59633576
115ACVR1B0.59104835
116CHEK10.58687292
117SRPK10.58600192
118DMPK0.58372344
119MUSK0.57941315
120CDK40.57006577
121MET0.56435389
122CHUK0.55770345
123NTRK20.54999418
124MATK0.54521223
125PIK3CA0.54022093
126FGFR30.48785227
127SGK20.48000094
128TAF10.47926876
129ATM0.47902680
130CAMK2A0.47646997
131PTK2B0.47021243
132TEC0.46031248
133MAPKAPK30.45829378
134PRKAA20.45661406
135TXK0.44217224
136CSNK1A1L0.44045488
137CSNK1G30.44032998
138AKT10.41015459
139BRD40.40642292
140CDK90.40494744
141CDK20.40452734
142CSNK1G10.39755567
143STK380.38787671
144CAMK1D0.38591342
145AURKA0.38570516
146PDK20.38342067
147CDK190.37622116
148BRAF0.36945576
149DYRK20.36705623
150CDK10.36395676
151ROCK20.36303503
152MAPK10.36074312
153AKT20.35682088
154PHKG20.35498190
155PHKG10.35498190
156CSNK1D0.35432256
157PRKG10.33934713
158MAP3K70.33019424
159DYRK30.32551693
160NME10.32327552
161PRKACA0.32050907
162PRKACB0.30832912
163STK110.30689071
164CSNK1A10.30321784
165CAMK10.29087829
166STK160.29027500
167KIT0.28746806
168SGK4940.28664467
169SGK2230.28664467

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.74720643
2Cell cycle_Homo sapiens_hsa041102.71435800
3Butanoate metabolism_Homo sapiens_hsa006502.61991791
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.55663691
5Basal cell carcinoma_Homo sapiens_hsa052172.49753288
6ECM-receptor interaction_Homo sapiens_hsa045122.41002886
7Hippo signaling pathway_Homo sapiens_hsa043902.37170961
8Hedgehog signaling pathway_Homo sapiens_hsa043402.26657794
9Nicotine addiction_Homo sapiens_hsa050332.24139059
10TGF-beta signaling pathway_Homo sapiens_hsa043502.20807950
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.20627169
12Nitrogen metabolism_Homo sapiens_hsa009102.19868749
13Adherens junction_Homo sapiens_hsa045202.17516507
14Linoleic acid metabolism_Homo sapiens_hsa005912.16161112
15Propanoate metabolism_Homo sapiens_hsa006402.15315591
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.09855561
17Small cell lung cancer_Homo sapiens_hsa052222.09576354
18Tryptophan metabolism_Homo sapiens_hsa003802.05798972
19Selenocompound metabolism_Homo sapiens_hsa004502.01025808
20Focal adhesion_Homo sapiens_hsa045101.97396643
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.95825473
22RNA transport_Homo sapiens_hsa030131.91753809
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.88567850
24Proteoglycans in cancer_Homo sapiens_hsa052051.87045210
25MicroRNAs in cancer_Homo sapiens_hsa052061.85225620
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79739992
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.79737303
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.79044146
29Thyroid cancer_Homo sapiens_hsa052161.76205057
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73173942
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68572739
32ABC transporters_Homo sapiens_hsa020101.64732550
33DNA replication_Homo sapiens_hsa030301.61848539
34Taste transduction_Homo sapiens_hsa047421.61254243
35Olfactory transduction_Homo sapiens_hsa047401.59999733
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.57047517
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.54559328
38Ether lipid metabolism_Homo sapiens_hsa005651.54541437
39Chronic myeloid leukemia_Homo sapiens_hsa052201.52885120
40p53 signaling pathway_Homo sapiens_hsa041151.52339669
41Protein digestion and absorption_Homo sapiens_hsa049741.52301432
42Spliceosome_Homo sapiens_hsa030401.51897209
43Viral myocarditis_Homo sapiens_hsa054161.50750667
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49113427
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.47061057
46Pathways in cancer_Homo sapiens_hsa052001.45333950
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.45304665
48Morphine addiction_Homo sapiens_hsa050321.44079644
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.42215976
50Bladder cancer_Homo sapiens_hsa052191.40701252
51Mismatch repair_Homo sapiens_hsa034301.40574647
52Oocyte meiosis_Homo sapiens_hsa041141.38026058
53Caffeine metabolism_Homo sapiens_hsa002321.37458703
54Renin-angiotensin system_Homo sapiens_hsa046141.37189948
55Steroid hormone biosynthesis_Homo sapiens_hsa001401.34838092
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34136307
57Prostate cancer_Homo sapiens_hsa052151.33431852
58Wnt signaling pathway_Homo sapiens_hsa043101.32337558
59Tight junction_Homo sapiens_hsa045301.32073784
60Colorectal cancer_Homo sapiens_hsa052101.29782511
61mRNA surveillance pathway_Homo sapiens_hsa030151.28939059
62Pancreatic cancer_Homo sapiens_hsa052121.28660018
63HTLV-I infection_Homo sapiens_hsa051661.26045306
64Base excision repair_Homo sapiens_hsa034101.25213086
65Melanoma_Homo sapiens_hsa052181.24418545
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.24340725
67PI3K-Akt signaling pathway_Homo sapiens_hsa041511.24109630
68Endometrial cancer_Homo sapiens_hsa052131.21565862
69Amoebiasis_Homo sapiens_hsa051461.20648968
70RNA degradation_Homo sapiens_hsa030181.17249575
71Circadian entrainment_Homo sapiens_hsa047131.15791480
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15096456
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15030102
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14819115
75Serotonergic synapse_Homo sapiens_hsa047261.13696020
76mTOR signaling pathway_Homo sapiens_hsa041501.12127640
77Dilated cardiomyopathy_Homo sapiens_hsa054141.11976185
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11897780
79Nucleotide excision repair_Homo sapiens_hsa034201.10218484
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08149291
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07577798
82beta-Alanine metabolism_Homo sapiens_hsa004101.07428494
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07087612
84Calcium signaling pathway_Homo sapiens_hsa040201.06515284
85Retinol metabolism_Homo sapiens_hsa008301.06269261
86Glutamatergic synapse_Homo sapiens_hsa047241.06139416
87Viral carcinogenesis_Homo sapiens_hsa052031.04855276
88GABAergic synapse_Homo sapiens_hsa047271.03796664
89Axon guidance_Homo sapiens_hsa043601.02952599
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.99858833
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99207231
92Chemical carcinogenesis_Homo sapiens_hsa052040.98971672
93Homologous recombination_Homo sapiens_hsa034400.98284479
94Notch signaling pathway_Homo sapiens_hsa043300.97069081
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95941219
96Glycerolipid metabolism_Homo sapiens_hsa005610.94312699
97Epstein-Barr virus infection_Homo sapiens_hsa051690.93155034
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92810599
99Rap1 signaling pathway_Homo sapiens_hsa040150.92741814
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92653221
101Protein export_Homo sapiens_hsa030600.92528909
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92153602
103Shigellosis_Homo sapiens_hsa051310.91845868
104Peroxisome_Homo sapiens_hsa041460.90216556
105Melanogenesis_Homo sapiens_hsa049160.89680625
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88446936
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.87898259
108Glioma_Homo sapiens_hsa052140.87135961
109Basal transcription factors_Homo sapiens_hsa030220.86163648
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85414967
111Salivary secretion_Homo sapiens_hsa049700.84516460
112Insulin secretion_Homo sapiens_hsa049110.84241803
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84174266
114Fatty acid degradation_Homo sapiens_hsa000710.83955589
115Histidine metabolism_Homo sapiens_hsa003400.79684346
116Steroid biosynthesis_Homo sapiens_hsa001000.79289675
117Renal cell carcinoma_Homo sapiens_hsa052110.78541703
118Toxoplasmosis_Homo sapiens_hsa051450.78248271
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.77989623
120Non-small cell lung cancer_Homo sapiens_hsa052230.77682539
121HIF-1 signaling pathway_Homo sapiens_hsa040660.76571555
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.75837917
123N-Glycan biosynthesis_Homo sapiens_hsa005100.73161946
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72888525
125Arachidonic acid metabolism_Homo sapiens_hsa005900.72779425
126Long-term depression_Homo sapiens_hsa047300.72477458
127Ovarian steroidogenesis_Homo sapiens_hsa049130.72265601
128Fat digestion and absorption_Homo sapiens_hsa049750.71867305
129Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71303850
130Fatty acid biosynthesis_Homo sapiens_hsa000610.71061642
131FoxO signaling pathway_Homo sapiens_hsa040680.71037026
132Hepatitis B_Homo sapiens_hsa051610.68126182
133RNA polymerase_Homo sapiens_hsa030200.67582342
134VEGF signaling pathway_Homo sapiens_hsa043700.67523983
135Ribosome_Homo sapiens_hsa030100.66835732
136Prolactin signaling pathway_Homo sapiens_hsa049170.66381586
137TNF signaling pathway_Homo sapiens_hsa046680.65792971
138Platelet activation_Homo sapiens_hsa046110.65546530
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64853250
140Apoptosis_Homo sapiens_hsa042100.64258396
141Fatty acid metabolism_Homo sapiens_hsa012120.64088092
142Cardiac muscle contraction_Homo sapiens_hsa042600.63589824
143Herpes simplex infection_Homo sapiens_hsa051680.63145750
144One carbon pool by folate_Homo sapiens_hsa006700.62693680
145Fanconi anemia pathway_Homo sapiens_hsa034600.62607739
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62461042
147Oxidative phosphorylation_Homo sapiens_hsa001900.62129913
148Purine metabolism_Homo sapiens_hsa002300.62055605
149Dorso-ventral axis formation_Homo sapiens_hsa043200.61594955
150Cysteine and methionine metabolism_Homo sapiens_hsa002700.59586604
151Huntingtons disease_Homo sapiens_hsa050160.58642941
152cAMP signaling pathway_Homo sapiens_hsa040240.57574810
153Regulation of autophagy_Homo sapiens_hsa041400.56995694
154Circadian rhythm_Homo sapiens_hsa047100.56745047
155Gap junction_Homo sapiens_hsa045400.53841962
156Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52244202
157Estrogen signaling pathway_Homo sapiens_hsa049150.52181466
158Non-homologous end-joining_Homo sapiens_hsa034500.50136612
159Metabolic pathways_Homo sapiens_hsa011000.49057902
160Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49007166
161Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48768913
162Dopaminergic synapse_Homo sapiens_hsa047280.48679167
163Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48036223
164Parkinsons disease_Homo sapiens_hsa050120.47586680
165Acute myeloid leukemia_Homo sapiens_hsa052210.47200876
166Lysine degradation_Homo sapiens_hsa003100.47198189
167Cholinergic synapse_Homo sapiens_hsa047250.47151547
168Vitamin digestion and absorption_Homo sapiens_hsa049770.45900121
169Oxytocin signaling pathway_Homo sapiens_hsa049210.45385576
170Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44515933
171Ras signaling pathway_Homo sapiens_hsa040140.44215784
172Sphingolipid metabolism_Homo sapiens_hsa006000.42880286
173Renin secretion_Homo sapiens_hsa049240.42117223
174Systemic lupus erythematosus_Homo sapiens_hsa053220.41157388
175cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40905679

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