ARHGAP29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Rap1 is a small GTPase that, through effectors, regulates Rho GTPase signaling. These effectors- Rasip1, Radil, and the protein encoded by this gene- translocate to the cell membrane, where they form a multiprotein complex. This complex is necessary for Rap1-induced inhibition of Rho signaling. Defects in this gene may be a cause of nonsyndromic cleft lip with or without cleft palate. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)5.13121894
2hemidesmosome assembly (GO:0031581)4.94357778
3vascular endothelial growth factor signaling pathway (GO:0038084)4.62250964
4skin morphogenesis (GO:0043589)4.55721957
5retina vasculature morphogenesis in camera-type eye (GO:0061299)4.54544263
6desmosome organization (GO:0002934)3.98884446
7basement membrane organization (GO:0071711)3.95611787
8regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.88695321
9low-density lipoprotein particle clearance (GO:0034383)3.84380339
10endothelium development (GO:0003158)3.78253870
11substrate-dependent cell migration (GO:0006929)3.77545128
12regulation of transforming growth factor beta2 production (GO:0032909)3.76723647
13mesodermal cell differentiation (GO:0048333)3.74199238
14lymphangiogenesis (GO:0001946)3.70103488
15wound healing, spreading of epidermal cells (GO:0035313)3.66264810
16cell-substrate junction assembly (GO:0007044)3.59335307
17endothelial cell morphogenesis (GO:0001886)3.55548099
18negative regulation of chondrocyte differentiation (GO:0032331)3.53444161
19cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.49696423
20regulation of hippo signaling (GO:0035330)3.48791564
21fatty acid transmembrane transport (GO:1902001)3.48164553
22alpha-linolenic acid metabolic process (GO:0036109)3.47521544
23positive regulation of fatty acid beta-oxidation (GO:0032000)3.44509684
24ovulation from ovarian follicle (GO:0001542)3.43199150
25negative regulation of fibrinolysis (GO:0051918)3.41437111
26glomerular filtration (GO:0003094)3.40620916
27cell migration involved in sprouting angiogenesis (GO:0002042)3.36744855
28protein localization to endosome (GO:0036010)3.34473862
29plasma membrane repair (GO:0001778)3.30848499
30membrane raft organization (GO:0031579)3.30397332
31regulation of protein activation cascade (GO:2000257)3.29746956
32paraxial mesoderm development (GO:0048339)3.28303402
33bundle of His cell to Purkinje myocyte communication (GO:0086069)3.27351588
34complement activation, alternative pathway (GO:0006957)3.26066334
35renal filtration (GO:0097205)3.25884791
36regulation of complement activation (GO:0030449)3.25094105
37regulation of endothelial cell differentiation (GO:0045601)3.18429733
38Golgi transport vesicle coating (GO:0048200)3.17451787
39COPI coating of Golgi vesicle (GO:0048205)3.17451787
40SMAD protein complex assembly (GO:0007183)3.17036522
41hippo signaling (GO:0035329)3.14163789
42carnitine shuttle (GO:0006853)3.13515088
43negative regulation of keratinocyte proliferation (GO:0010839)3.12035536
44epoxygenase P450 pathway (GO:0019373)3.11915534
45chondrocyte proliferation (GO:0035988)3.10836194
46endodermal cell differentiation (GO:0035987)3.10603469
47notochord development (GO:0030903)3.10241350
48keratinocyte proliferation (GO:0043616)3.09319377
49substrate adhesion-dependent cell spreading (GO:0034446)3.08844644
50blood vessel endothelial cell migration (GO:0043534)3.08585979
51hypotonic response (GO:0006971)3.08015100
52positive regulation of fatty acid oxidation (GO:0046321)3.05458071
53dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.03999401
54peptidyl-glutamic acid carboxylation (GO:0017187)3.01494616
55protein carboxylation (GO:0018214)3.01494616
56regulation of sequestering of triglyceride (GO:0010889)3.01289427
57regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.00476544
58regulation of fibrinolysis (GO:0051917)2.99909345
59fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.99500085
60positive regulation of vasculogenesis (GO:2001214)2.99325409
61endocardial cushion development (GO:0003197)2.98856691
62negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.98701667
63midgut development (GO:0007494)2.98091646
64L-phenylalanine catabolic process (GO:0006559)2.96834936
65erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.96834936
66transcytosis (GO:0045056)2.94484855
67cytoskeletal anchoring at plasma membrane (GO:0007016)2.92917887
68blood vessel maturation (GO:0001955)2.92002976
69surfactant homeostasis (GO:0043129)2.91687729
70regulation of fatty acid beta-oxidation (GO:0031998)2.89277317
71wound healing, spreading of cells (GO:0044319)2.88588234
72glomerular visceral epithelial cell development (GO:0072015)2.86333940
73regulation of vasculogenesis (GO:2001212)2.85504579
74patterning of blood vessels (GO:0001569)2.84491351
75lysine metabolic process (GO:0006553)2.83322160
76lysine catabolic process (GO:0006554)2.83322160
77vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.81900184
78L-phenylalanine metabolic process (GO:0006558)2.81333358
79erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.81333358
80carnitine transmembrane transport (GO:1902603)2.79371164
81plasma lipoprotein particle clearance (GO:0034381)2.79367491
82fatty acid beta-oxidation (GO:0006635)2.78771696
83adherens junction assembly (GO:0034333)2.77749894
84triglyceride homeostasis (GO:0070328)2.77704543
85acylglycerol homeostasis (GO:0055090)2.77704543
86regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.76723146
87muscle cell migration (GO:0014812)2.75612979
88focal adhesion assembly (GO:0048041)2.75578752
89cell-substrate adherens junction assembly (GO:0007045)2.75578752
90triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.75285648
91amino-acid betaine transport (GO:0015838)2.75049442
92carnitine transport (GO:0015879)2.75049442
93regulation of transforming growth factor beta1 production (GO:0032908)2.73587489
94homocysteine metabolic process (GO:0050667)2.73189723
95negative regulation of anoikis (GO:2000811)2.71195323
96glyoxylate metabolic process (GO:0046487)2.70666539
97negative regulation of fatty acid transport (GO:2000192)2.69733962
98heart trabecula formation (GO:0060347)2.69153894
99regulation of glomerular filtration (GO:0003093)2.68080944
100triglyceride catabolic process (GO:0019433)2.67836299
101cell adhesion mediated by integrin (GO:0033627)2.67449837
102type B pancreatic cell proliferation (GO:0044342)2.67253870
103sulfur amino acid catabolic process (GO:0000098)2.67080803
104collagen fibril organization (GO:0030199)2.66650005
105gap junction assembly (GO:0016264)2.66608850
106mitotic cytokinesis (GO:0000281)2.63542104
107urea cycle (GO:0000050)2.63532648
108urea metabolic process (GO:0019627)2.63532648
109COPII vesicle coating (GO:0048208)2.63088647
110glomerular basement membrane development (GO:0032836)2.63027135
111negative regulation of cartilage development (GO:0061037)2.62958713
112protein heterotrimerization (GO:0070208)2.62705122
113fatty acid oxidation (GO:0019395)2.62646525
114embryonic heart tube development (GO:0035050)2.62628264
115kidney mesenchyme development (GO:0072074)2.62168281
116amino-acid betaine metabolic process (GO:0006577)2.59881630
117protein hydroxylation (GO:0018126)2.59559684
118artery development (GO:0060840)2.58907743
119insulin-like growth factor receptor signaling pathway (GO:0048009)2.58546047
120biotin metabolic process (GO:0006768)2.58214869
121regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.57463600
122positive regulation of endothelial cell migration (GO:0010595)2.56901785
123embryonic foregut morphogenesis (GO:0048617)2.55577034
124aromatic amino acid family catabolic process (GO:0009074)2.55243972
125nuclear pore complex assembly (GO:0051292)2.54758362
126lipid oxidation (GO:0034440)2.54689478
127valine metabolic process (GO:0006573)2.54022151
128positive regulation of osteoblast proliferation (GO:0033690)2.53994459
129regulation of triglyceride catabolic process (GO:0010896)2.53729489
130regulation of fatty acid oxidation (GO:0046320)2.53447582
131pericardium development (GO:0060039)2.51892412
132endothelial tube morphogenesis (GO:0061154)2.51595675
133morphogenesis of an endothelium (GO:0003159)2.51595675
134neutral lipid catabolic process (GO:0046461)2.51448937
135acylglycerol catabolic process (GO:0046464)2.51448937
136negative regulation of blood coagulation (GO:0030195)2.51049479
137negative regulation of hemostasis (GO:1900047)2.51049479
138epithelial cell-cell adhesion (GO:0090136)2.50982676
139fibrinolysis (GO:0042730)2.50956920
140sprouting angiogenesis (GO:0002040)2.50093029
141lung vasculature development (GO:0060426)2.50015504
142cytoskeleton-dependent cytokinesis (GO:0061640)2.49921611
143regulation of cardioblast differentiation (GO:0051890)2.49134215
144UDP-N-acetylglucosamine metabolic process (GO:0006047)2.48724015
145regulation of cholesterol storage (GO:0010885)2.48717914
146positive regulation of glycolytic process (GO:0045821)2.48633562
147cell junction assembly (GO:0034329)2.47895647
148axon extension involved in axon guidance (GO:0048846)2.47828720
149neuron projection extension involved in neuron projection guidance (GO:1902284)2.47828720
150bile acid biosynthetic process (GO:0006699)2.47553798
151cysteine metabolic process (GO:0006534)2.47420423
152positive regulation of endothelial cell apoptotic process (GO:2000353)2.46707060
153positive regulation of lipid catabolic process (GO:0050996)2.45610733
154positive regulation of focal adhesion assembly (GO:0051894)2.45470836
155positive regulation of cell junction assembly (GO:1901890)2.45470836
156positive regulation of epithelial cell migration (GO:0010634)2.44981093
157negative regulation of axon extension involved in axon guidance (GO:0048843)2.44677801
158protein localization to cell surface (GO:0034394)2.44248699
159ovulation (GO:0030728)2.42966660
160positive regulation of adherens junction organization (GO:1903393)2.42525466
161endothelial cell proliferation (GO:0001935)2.42474725
162maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.41994813
163quaternary ammonium group transport (GO:0015697)2.41988553
164cell-cell junction assembly (GO:0007043)2.41275140
165regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.40476984
166smooth muscle tissue development (GO:0048745)2.40178373
167fatty acid catabolic process (GO:0009062)2.38953685
168coronary vasculature morphogenesis (GO:0060977)2.38052261
169vasculogenesis (GO:0001570)2.37548562
170glomerular epithelial cell development (GO:0072310)2.36858575
171metanephric mesenchyme development (GO:0072075)2.35928003
172regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.35724123
173positive regulation of blood vessel endothelial cell migration (GO:0043536)2.35228498
174endothelial cell chemotaxis (GO:0035767)2.35048529
175positive regulation of actin filament depolymerization (GO:0030836)2.32457221
176mesenchymal-epithelial cell signaling (GO:0060638)2.31447880
177bone remodeling (GO:0046849)2.30742488
178morphogenesis of an epithelial sheet (GO:0002011)2.30201953
179activation of Rac GTPase activity (GO:0032863)2.29590612
180negative regulation of stem cell proliferation (GO:2000647)2.29576508

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.06401605
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.93378403
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.89069967
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.77497215
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.62625324
6CLOCK_20551151_ChIP-Seq_293T_Human3.51024811
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.24903461
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.83507395
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.74033984
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.71923208
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.70839263
12EP300_21415370_ChIP-Seq_HL-1_Mouse2.48057514
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.37962381
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.37827754
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.15426755
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.12200357
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.07723276
18SALL4_18804426_ChIP-ChIP_XEN_Mouse1.99421098
19GATA2_21666600_ChIP-Seq_HMVEC_Human1.97645830
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95445307
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.92872559
22* CJUN_26792858_Chip-Seq_BT549_Human1.88745007
23CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.87965662
24CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.80647374
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80165986
26* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.78807285
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78426387
28CTNNB1_20460455_ChIP-Seq_HCT116_Human1.78189857
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.74365513
30WT1_19549856_ChIP-ChIP_CCG9911_Human1.74171390
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.72150320
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71473617
33TBX20_22080862_ChIP-Seq_HEART_Mouse1.65894244
34TBX20_22328084_ChIP-Seq_HEART_Mouse1.65894244
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63642089
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.63225033
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.54570790
38* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.51053747
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49989036
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.46954762
41EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.45493944
42* BRD4_25478319_ChIP-Seq_HGPS_Human1.42118585
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.40749381
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40084600
45EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.38377855
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36494021
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36494021
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.35361530
49ATF3_27146783_Chip-Seq_COLON_Human1.34769082
50TCF4_18268006_ChIP-ChIP_LS174T_Human1.33899825
51SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31360698
52KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31124308
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28294282
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26858252
55ZNF263_19887448_ChIP-Seq_K562_Human1.26717618
56BCAT_22108803_ChIP-Seq_LS180_Human1.26446289
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26401429
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24834188
59CDX2_20551321_ChIP-Seq_CACO-2_Human1.23558991
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22743605
61ISL1_27105846_Chip-Seq_CPCs_Mouse1.22382416
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21360379
63ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.20726192
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20354935
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19431737
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19431737
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19000810
68TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16813102
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16632363
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16469877
71* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.16395328
72AR_21909140_ChIP-Seq_LNCAP_Human1.15824994
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13899807
74SOX2_20726797_ChIP-Seq_SW620_Human1.13090964
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.12279334
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09451287
77AHR_22903824_ChIP-Seq_MCF-7_Human1.09109025
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08363499
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07077577
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06837536
81GATA4_25053715_ChIP-Seq_YYC3_Human1.06350139
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04910934
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03992512
84GATA1_22025678_ChIP-Seq_K562_Human1.01876111
85SOX17_20123909_ChIP-Seq_XEN_Mouse1.01284737
86JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00213671
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.99158420
88FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99111903
89TP63_23658742_ChIP-Seq_EP156T_Human0.98093103
90EGR1_19374776_ChIP-ChIP_THP-1_Human0.98020583
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96450642
92MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96434529
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.95595966
94TP53_22127205_ChIP-Seq_IMR90_Human0.95550182
95MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94631140
96CDX2_22108803_ChIP-Seq_LS180_Human0.93122204
97JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92262658
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91355167
99* UBF1/2_26484160_Chip-Seq_HMECs_Human0.91227828
100DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90809892
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90688533
102ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90626807
103ARNT_22903824_ChIP-Seq_MCF-7_Human0.89202864
104TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.88744990
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87955331
106PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.87699253
107ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87362519
108YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87217443
109FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.87043633
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86970328
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86057762
112TP53_16413492_ChIP-PET_HCT116_Human0.84943147
113ELK3_25401928_ChIP-Seq_HUVEC_Human0.84776624
114* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84601349
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.81431959
116NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.81376946
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80843957
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80004332
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.79634823
120* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78438641
121* HNF4A_19822575_ChIP-Seq_HepG2_Human0.78095454
122WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78057910
123TP53_18474530_ChIP-ChIP_U2OS_Human0.76438590
124GATA3_24758297_ChIP-Seq_MCF-7_Human0.74915927

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system4.05524654
2MP0008438_abnormal_cutaneous_collagen3.95131634
3MP0004272_abnormal_basement_membrane3.89395578
4MP0003705_abnormal_hypodermis_morpholog3.17186512
5MP0001879_abnormal_lymphatic_vessel3.05349157
6MP0002139_abnormal_hepatobiliary_system3.00754060
7MP0005360_urolithiasis2.81818561
8MP0005275_abnormal_skin_tensile2.75089727
9MP0002877_abnormal_melanocyte_morpholog2.70452907
10MP0009780_abnormal_chondrocyte_physiolo2.45389957
11MP0005365_abnormal_bile_salt2.41143755
12MP0005670_abnormal_white_adipose2.29170035
13MP0005085_abnormal_gallbladder_physiolo2.26497133
14MP0005167_abnormal_blood-brain_barrier2.26068552
15MP0005623_abnormal_meninges_morphology2.14116538
16MP0003279_aneurysm2.13095107
17MP0005257_abnormal_intraocular_pressure2.10974574
18MP0004084_abnormal_cardiac_muscle1.98110792
19MP0003252_abnormal_bile_duct1.96413852
20MP0009384_cardiac_valve_regurgitation1.94727787
21MP0006054_spinal_hemorrhage1.88646763
22MP0005503_abnormal_tendon_morphology1.87417445
23MP0006138_congestive_heart_failure1.81185786
24MP0001958_emphysema1.62282045
25MP0010329_abnormal_lipoprotein_level1.61892074
26MP0000767_abnormal_smooth_muscle1.60186784
27MP0000762_abnormal_tongue_morphology1.58267603
28MP0005666_abnormal_adipose_tissue1.56741735
29MP0004130_abnormal_muscle_cell1.50246527
30MP0003828_pulmonary_edema1.49590384
31MP0008875_abnormal_xenobiotic_pharmacok1.48813691
32MP0004233_abnormal_muscle_weight1.42387696
33MP0002295_abnormal_pulmonary_circulatio1.38652859
34MP0000013_abnormal_adipose_tissue1.36878556
35MP0005410_abnormal_fertilization1.36122280
36MP0010030_abnormal_orbit_morphology1.35904315
37MP0003566_abnormal_cell_adhesion1.33596727
38MP0001348_abnormal_lacrimal_gland1.33008505
39MP0001661_extended_life_span1.29161871
40MP0010234_abnormal_vibrissa_follicle1.27866305
41MP0009053_abnormal_anal_canal1.27472852
42MP0005409_darkened_coat_color1.26644858
43MP0004185_abnormal_adipocyte_glucose1.26490004
44MP0010630_abnormal_cardiac_muscle1.23306852
45MP0001299_abnormal_eye_distance/1.23028393
46MP0000749_muscle_degeneration1.21740678
47MP0000534_abnormal_ureter_morphology1.20338400
48MP0005375_adipose_tissue_phenotype1.18845822
49MP0002128_abnormal_blood_circulation1.18694448
50MP0004036_abnormal_muscle_relaxation1.18001421
51MP0010678_abnormal_skin_adnexa1.17200624
52MP0004215_abnormal_myocardial_fiber1.15409951
53MP0008775_abnormal_heart_ventricle1.14341702
54MP0002138_abnormal_hepatobiliary_system1.11871880
55MP0009697_abnormal_copulation1.11866492
56MP0002108_abnormal_muscle_morphology1.10905165
57MP0005385_cardiovascular_system_phenoty1.10304309
58MP0001544_abnormal_cardiovascular_syste1.10304309
59MP0002060_abnormal_skin_morphology1.10215793
60MP0005076_abnormal_cell_differentiation1.09731115
61MP0005330_cardiomyopathy1.09271659
62MP0005084_abnormal_gallbladder_morpholo1.08817722
63MP0002332_abnormal_exercise_endurance1.06878074
64MP0003091_abnormal_cell_migration1.06044303
65MP0000537_abnormal_urethra_morphology1.05901509
66MP0000003_abnormal_adipose_tissue1.04711212
67MP0002234_abnormal_pharynx_morphology1.03775641
68MP0003950_abnormal_plasma_membrane1.03650692
69MP0005197_abnormal_uvea_morphology1.02255909
70MP0002837_dystrophic_cardiac_calcinosis1.01237624
71MP0000467_abnormal_esophagus_morphology0.99249102
72MP0002282_abnormal_trachea_morphology0.99040413
73MP0005647_abnormal_sex_gland0.99030917
74MP0005501_abnormal_skin_physiology0.98978943
75MP0001915_intracranial_hemorrhage0.98910163
76MP0005332_abnormal_amino_acid0.98795743
77MP0000733_abnormal_muscle_development0.98534147
78MP0001614_abnormal_blood_vessel0.97888426
79MP0002925_abnormal_cardiovascular_devel0.97034316
80MP0003385_abnormal_body_wall0.96512570
81MP0005595_abnormal_vascular_smooth0.96329987
82MP0000750_abnormal_muscle_regeneration0.96018756
83MP0004087_abnormal_muscle_fiber0.95375474
84MP0000428_abnormal_craniofacial_morphol0.94093210
85MP0002697_abnormal_eye_size0.93717237
86MP0003724_increased_susceptibility_to0.93694591
87MP0005164_abnormal_response_to0.93330592
88MP0003115_abnormal_respiratory_system0.92950749
89MP0002972_abnormal_cardiac_muscle0.92828692
90MP0002896_abnormal_bone_mineralization0.92684045
91MP0005620_abnormal_muscle_contractility0.91992379
92MP0002118_abnormal_lipid_homeostasis0.90576185
93MP0003937_abnormal_limbs/digits/tail_de0.89994561
94MP0002127_abnormal_cardiovascular_syste0.89824710
95MP0000609_abnormal_liver_physiology0.89052569
96MP0004782_abnormal_surfactant_physiolog0.88582091
97MP0005023_abnormal_wound_healing0.88273865
98MP0002971_abnormal_brown_adipose0.87094341
99MP0003755_abnormal_palate_morphology0.86882382
100MP0003941_abnormal_skin_development0.86786788
101MP0004484_altered_response_of0.85363746
102MP0003191_abnormal_cellular_cholesterol0.85089475
103MP0003567_abnormal_fetal_cardiomyocyte0.84467216
104MP0000249_abnormal_blood_vessel0.83413998
105MP0005508_abnormal_skeleton_morphology0.83358747
106MP0002168_other_aberrant_phenotype0.82137280
107MP0000751_myopathy0.81907526
108MP0000266_abnormal_heart_morphology0.81619892
109MP0001243_abnormal_dermal_layer0.81591518
110MP0003868_abnormal_feces_composition0.81386907
111MP0001216_abnormal_epidermal_layer0.81370758
112MP0002092_abnormal_eye_morphology0.80494054
113MP0002084_abnormal_developmental_patter0.79579620
114MP0000759_abnormal_skeletal_muscle0.79305275
115MP0010352_gastrointestinal_tract_polyps0.78584909
116MP0003453_abnormal_keratinocyte_physiol0.77706205
117MP0009250_abnormal_appendicular_skeleto0.77137296
118MP0000432_abnormal_head_morphology0.76874163
119MP0000383_abnormal_hair_follicle0.76336947
120MP0001849_ear_inflammation0.76266384
121MP0005187_abnormal_penis_morphology0.75602325
122MP0002796_impaired_skin_barrier0.75311226
123MP0010771_integument_phenotype0.75213242
124MP0003942_abnormal_urinary_system0.74499042
125MP0001542_abnormal_bone_strength0.73916143
126MP0003984_embryonic_growth_retardation0.73727770
127MP0003943_abnormal_hepatobiliary_system0.73694692
128MP0001672_abnormal_embryogenesis/_devel0.73256037
129MP0005380_embryogenesis_phenotype0.73256037
130MP0002088_abnormal_embryonic_growth/wei0.73164073
131MP0003045_fibrosis0.72763753
132MP0003300_gastrointestinal_ulcer0.72591490
133MP0009115_abnormal_fat_cell0.72153633
134MP0003935_abnormal_craniofacial_develop0.71983841
135MP0003806_abnormal_nucleotide_metabolis0.70739864
136MP0005408_hypopigmentation0.69605778
137MP0002086_abnormal_extraembryonic_tissu0.69278379
138MP0005193_abnormal_anterior_eye0.68838994
139MP0005319_abnormal_enzyme/_coenzyme0.68436352
140MP0004883_abnormal_blood_vessel0.68087910
141MP0002269_muscular_atrophy0.67583852
142MP0005248_abnormal_Harderian_gland0.67197444
143MP0005165_increased_susceptibility_to0.66666057
144MP0000516_abnormal_urinary_system0.66597798

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.65945106
2Arterial tortuosity (HP:0005116)4.46578289
3Deep venous thrombosis (HP:0002625)4.31456498
4Premature rupture of membranes (HP:0001788)4.26245805
5Broad metatarsal (HP:0001783)3.63459689
6Cerebral aneurysm (HP:0004944)3.36263567
7Aortic aneurysm (HP:0004942)3.25340997
8Aortic dissection (HP:0002647)3.24544480
9Increased connective tissue (HP:0009025)3.21596914
10Short nail (HP:0001799)3.20278167
11Lymphangioma (HP:0100764)3.17766991
12Hypoglycemic coma (HP:0001325)3.16913335
13Esophageal varix (HP:0002040)3.16264070
14Hypoalphalipoproteinemia (HP:0003233)3.06805829
15Reduced subcutaneous adipose tissue (HP:0003758)2.99362673
16Xanthomatosis (HP:0000991)2.98233473
17Osteolytic defects of the phalanges of the hand (HP:0009771)2.98217990
18Complement deficiency (HP:0004431)2.93263869
19Ankle contracture (HP:0006466)2.93085899
20Polycythemia (HP:0001901)2.90850077
21Intrahepatic cholestasis (HP:0001406)2.89990677
22Hematochezia (HP:0002573)2.84700055
23Shallow orbits (HP:0000586)2.82878279
24Cervical subluxation (HP:0003308)2.71364592
25Right ventricular cardiomyopathy (HP:0011663)2.69551657
26Spinal rigidity (HP:0003306)2.68104753
27Wormian bones (HP:0002645)2.67516716
28Acanthosis nigricans (HP:0000956)2.64546122
29Muscle fiber splitting (HP:0003555)2.63193945
30Mitral valve prolapse (HP:0001634)2.60966498
31Hyporeflexia of lower limbs (HP:0002600)2.58944255
32Hemorrhage of the eye (HP:0011885)2.58324883
33Aneurysm (HP:0002617)2.51262374
34Hyperlipoproteinemia (HP:0010980)2.49674284
35Mitral stenosis (HP:0001718)2.47458427
36Hypolipoproteinemia (HP:0010981)2.45079052
37Myocardial infarction (HP:0001658)2.40835001
38Hyperglycinuria (HP:0003108)2.39991329
39Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.37990218
40Neonatal short-limb short stature (HP:0008921)2.36621951
41Abnormality of monocarboxylic acid metabolism (HP:0010996)2.30615416
42Atrophic scars (HP:0001075)2.26652362
43Soft skin (HP:0000977)2.25664266
44Peritonitis (HP:0002586)2.24641507
45Type 1 muscle fiber predominance (HP:0003803)2.23488544
46Follicular hyperkeratosis (HP:0007502)2.18874320
47Broad face (HP:0000283)2.18862959
48Abnormality of serine family amino acid metabolism (HP:0010894)2.17977407
49Abnormality of glycine metabolism (HP:0010895)2.17977407
50Nonimmune hydrops fetalis (HP:0001790)2.17418927
51Hyperammonemia (HP:0001987)2.17323235
52Cardiovascular calcification (HP:0011915)2.16460848
53Epidermoid cyst (HP:0200040)2.15063964
54Abnormality of the intrinsic pathway (HP:0010989)2.14357402
55Ketosis (HP:0001946)2.14024677
56Venous insufficiency (HP:0005293)2.13379135
57Visceral angiomatosis (HP:0100761)2.10582200
58Abnormality of the common coagulation pathway (HP:0010990)2.10087107
59Vascular calcification (HP:0004934)2.09763082
60Venous abnormality (HP:0002624)2.08729722
61Glucose intolerance (HP:0000833)2.07956879
62Hyperglycinemia (HP:0002154)2.07329655
63Short hallux (HP:0010109)2.06678138
64Difficulty running (HP:0009046)2.05949465
65Prolonged partial thromboplastin time (HP:0003645)2.04480627
66Abnormality of complement system (HP:0005339)2.03121429
67Bladder diverticulum (HP:0000015)2.02662207
68Increased variability in muscle fiber diameter (HP:0003557)2.02000134
69Vertebral arch anomaly (HP:0008438)2.01538971
70Ulnar bowing (HP:0003031)2.01463769
71Abnormality of the acetabulum (HP:0003170)2.00656788
72Mildly elevated creatine phosphokinase (HP:0008180)2.00403863
73Natal tooth (HP:0000695)2.00091943
74Spondylolisthesis (HP:0003302)1.99174670
75Onycholysis (HP:0001806)1.99018883
76Hemangiomatosis (HP:0007461)1.98606555
77Aortic valve stenosis (HP:0001650)1.98465044
78Abnormality of the distal phalanges of the toes (HP:0010182)1.98413047
79Hepatocellular carcinoma (HP:0001402)1.97441343
80Abnormality of glutamine family amino acid metabolism (HP:0010902)1.95132173
81Striae distensae (HP:0001065)1.94279098
82Hyperglycemia (HP:0003074)1.93650112
83Wide anterior fontanel (HP:0000260)1.93598622
84Enlarged penis (HP:0000040)1.92909152
85Lipoatrophy (HP:0100578)1.92586947
86Hypobetalipoproteinemia (HP:0003563)1.92476523
87Asymmetry of the thorax (HP:0001555)1.91623480
88Dilatation of the ascending aorta (HP:0005111)1.91398289
89Blue sclerae (HP:0000592)1.91110570
90Ventricular tachycardia (HP:0004756)1.91068225
91Entropion (HP:0000621)1.90673009
92Elbow flexion contracture (HP:0002987)1.89698256
93Knee flexion contracture (HP:0006380)1.89233130
94Wrist flexion contracture (HP:0001239)1.89193555
95Hypercholesterolemia (HP:0003124)1.89106111
96Abnormal delivery (HP:0001787)1.88713845
97Vertebral compression fractures (HP:0002953)1.88500188
98Ankyloglossia (HP:0010296)1.88170226
99Overgrowth (HP:0001548)1.88025289
100Conjunctival telangiectasia (HP:0000524)1.87529974
101Portal hypertension (HP:0001409)1.87510401
102Ectopia lentis (HP:0001083)1.86887818
103Abnormal cartilage morphology (HP:0002763)1.86570501
104Abnormality of aromatic amino acid family metabolism (HP:0004338)1.85925972
105Alopecia of scalp (HP:0002293)1.85741814
106Aplasia/Hypoplasia of the hallux (HP:0008362)1.85547080
107Abnormality of the 4th metacarpal (HP:0010012)1.84965013
108Trismus (HP:0000211)1.83406390
109Skin nodule (HP:0200036)1.82904095
110Abnormality of dentin (HP:0010299)1.82618168
111Aortic regurgitation (HP:0001659)1.82603567
112Abnormality of oral frenula (HP:0000190)1.82559842
113Hypoplastic ischia (HP:0003175)1.82541615
114Hypertriglyceridemia (HP:0002155)1.82140826
115Fragile skin (HP:0001030)1.81850350
116Coronal craniosynostosis (HP:0004440)1.80814262
117Mitral regurgitation (HP:0001653)1.80582691
118Microglossia (HP:0000171)1.80046841
119Vascular tortuosity (HP:0004948)1.79560974
120Difficulty climbing stairs (HP:0003551)1.79521161
121Abnormality of fatty-acid metabolism (HP:0004359)1.78375883
122Hypoplasia of the iris (HP:0007676)1.77750475
123Abnormality of the anterior chamber (HP:0000593)1.77742487
124Joint laxity (HP:0001388)1.77520339
125Abnormality of the ischium (HP:0003174)1.77074466
126Exercise-induced muscle cramps (HP:0003710)1.76845919
127Hyperinsulinemic hypoglycemia (HP:0000825)1.76842691
128Skull defect (HP:0001362)1.76685901
129Hypoglycemic seizures (HP:0002173)1.76667844
130Fibular aplasia (HP:0002990)1.76251445
131Subacute progressive viral hepatitis (HP:0006572)1.76072088
132Rectal prolapse (HP:0002035)1.75659545
133Spinal cord lesions (HP:0100561)1.75342946
134Syringomyelia (HP:0003396)1.75342946
135Abnormality of skeletal muscle fiber size (HP:0012084)1.74237714
136Buphthalmos (HP:0000557)1.74016789
137Advanced eruption of teeth (HP:0006288)1.73878659
138Abnormal auditory evoked potentials (HP:0006958)1.73866553
139Abnormality of carpal bone ossification (HP:0006257)1.73842746
140Osteolytic defects of the hand bones (HP:0009699)1.73790019
141Pterygium (HP:0001059)1.71949319
142Focal segmental glomerulosclerosis (HP:0000097)1.71909811
143Conjugated hyperbilirubinemia (HP:0002908)1.71414005
144Protruding ear (HP:0000411)1.70394773
145Neonatal death (HP:0003811)1.69792692
146Abnormal ossification of hand bones (HP:0005921)1.69636201
147Flat acetabular roof (HP:0003180)1.68864391
148Milia (HP:0001056)1.67970521
149Hyperextensible skin (HP:0000974)1.67317677
150Limited hip movement (HP:0008800)1.66595110
151Tetraparesis (HP:0002273)1.65998226
152Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.64228541
153Spinal cord compression (HP:0002176)1.63742231
154Missing ribs (HP:0000921)1.63379502
155Selective tooth agenesis (HP:0001592)1.62684783
156Distal lower limb amyotrophy (HP:0008944)1.62146875
157Thin skin (HP:0000963)1.61765691
158Deviation of the thumb (HP:0009603)1.57514590
159Tibial bowing (HP:0002982)1.57419773
160Short chin (HP:0000331)1.56976415
161Abnormality of the distal phalanx of the thumb (HP:0009617)1.56782109
162Bradycardia (HP:0001662)1.56707804
163Distal lower limb muscle weakness (HP:0009053)1.56491984
164Vertebral clefting (HP:0008428)1.53468663
165Pulmonic stenosis (HP:0001642)1.52607592

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.19232880
2KDR3.62881325
3LATS13.60636343
4PDK43.12104387
5PDK33.12104387
6PDK23.01032127
7TRIB32.42759061
8TGFBR22.27709593
9EPHB22.16847945
10PTK2B2.16149404
11FRK2.08026309
12PDGFRA2.06134000
13FGFR21.95729459
14MST41.94132755
15RIPK11.93217112
16SIK11.84189012
17TTN1.82297995
18CAMK1D1.82089785
19STK31.81762864
20BCKDK1.78205018
21PKN21.71061866
22INSRR1.66651790
23LATS21.62828980
24SCYL21.60697035
25NTRK11.56748522
26FER1.53674890
27PTK61.53406984
28STK38L1.51241558
29PRKD31.49270513
30MYLK1.45332093
31DMPK1.43517402
32CAMK1G1.43243314
33PBK1.42505091
34MAP3K121.40443546
35DDR21.40246167
36TGFBR11.37563236
37FGFR41.35160361
38CDK81.32588761
39LIMK11.32039041
40NUAK11.28555664
41ERN11.26373006
42NEK91.23894434
43MET1.15620440
44MOS1.10363333
45PAK21.09846951
46PTK21.09410889
47EIF2AK11.07768450
48PRKAA21.03698272
49FGFR31.01507882
50OBSCN0.99480975
51IRAK30.95143770
52ERBB30.94767197
53WNK40.94606946
54CDK60.94017806
55PDGFRB0.92838912
56MELK0.92630537
57MAP3K30.91059015
58NEK10.87722292
59EIF2AK30.87675694
60PIK3CA0.87194953
61TSSK60.85782613
62BUB10.83227790
63ERBB40.83125274
64FGFR10.82738149
65PAK40.82042749
66* MTOR0.77945540
67AKT30.77586418
68ICK0.76393669
69PNCK0.75769228
70TESK10.72887978
71MAP3K20.71865865
72WEE10.71160930
73MAP2K30.70555152
74BMPR1B0.68822890
75LRRK20.67722551
76PRKG20.66672686
77ROCK20.66615196
78STK390.65822756
79PRKD10.65471156
80MST1R0.64471688
81PAK30.64260595
82LMTK20.64155457
83ROCK10.63936904
84MAP3K90.63442684
85STK100.59321964
86CDK90.58963034
87PRKAA10.58936378
88GRK10.55117197
89GSK3A0.52568182
90MAPK70.51021920
91MAPK120.50259166
92IGF1R0.48827791
93KSR10.48110845
94MAP3K60.48100865
95MAP2K10.47965364
96PRKCE0.47647512
97EIF2AK20.46668461
98CDK120.46573773
99NEK20.43785981
100TYRO30.43309070
101RET0.43090587
102EPHA30.41037953
103NLK0.40896668
104FLT30.40891310
105INSR0.40604756
106BRSK10.40551137
107WNK10.40412542
108EPHB10.38502341
109BRD40.38389546
110AKT20.38349830
111TRPM70.37539751
112EPHA20.37341789
113ZAK0.37036858
114DYRK1B0.36096883
115AURKB0.36084009
116MAP3K80.35950395
117PAK60.35199222
118ABL20.34441827
119BMX0.34300713
120BRSK20.34040544
121CAMK2D0.33614822
122MAP3K100.33403609
123ADRBK10.31282250
124BCR0.30835335
125PIK3CG0.30483600
126PDPK10.30447446
127STK380.29289740
128SGK30.28608333
129TTK0.28124909
130ILK0.27847674
131MAPK110.27724763
132ARAF0.26603007
133CAMK2B0.25658405
134EGFR0.25657963
135CAMK2G0.25013801
136ERBB20.23599960
137SRC0.23312816
138TRIM280.23148515
139ABL10.22940269
140TAF10.21941766
141PRKCI0.21506204
142STK240.19165287

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.37733590
2Propanoate metabolism_Homo sapiens_hsa006402.88697099
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.82593856
4Fatty acid degradation_Homo sapiens_hsa000712.78374719
5PPAR signaling pathway_Homo sapiens_hsa033202.59175207
6Arginine biosynthesis_Homo sapiens_hsa002202.45798851
7Complement and coagulation cascades_Homo sapiens_hsa046102.41708409
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33086779
9Fatty acid metabolism_Homo sapiens_hsa012122.28469737
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.18876625
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.08821203
12ECM-receptor interaction_Homo sapiens_hsa045122.05970410
13Tryptophan metabolism_Homo sapiens_hsa003802.03847249
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.73987076
15Pyruvate metabolism_Homo sapiens_hsa006201.65926080
16Adherens junction_Homo sapiens_hsa045201.65231861
17Fatty acid biosynthesis_Homo sapiens_hsa000611.62157021
18Regulation of actin cytoskeleton_Homo sapiens_hsa048101.60424106
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59399354
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56024946
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54573333
22Focal adhesion_Homo sapiens_hsa045101.53155632
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50336189
24Thyroid cancer_Homo sapiens_hsa052161.49413969
25Bile secretion_Homo sapiens_hsa049761.44348878
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.38890625
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37597549
28Butanoate metabolism_Homo sapiens_hsa006501.36721661
29Caffeine metabolism_Homo sapiens_hsa002321.36486513
30Peroxisome_Homo sapiens_hsa041461.35688738
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.34558231
32Selenocompound metabolism_Homo sapiens_hsa004501.30486142
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28007986
34beta-Alanine metabolism_Homo sapiens_hsa004101.27356339
35Fat digestion and absorption_Homo sapiens_hsa049751.27338251
36Pancreatic cancer_Homo sapiens_hsa052121.27137451
37Lysine degradation_Homo sapiens_hsa003101.24394041
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.23257632
39Axon guidance_Homo sapiens_hsa043601.21802435
40Carbon metabolism_Homo sapiens_hsa012001.20028320
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19829721
42Chronic myeloid leukemia_Homo sapiens_hsa052201.19573909
43Vitamin B6 metabolism_Homo sapiens_hsa007501.17446541
44Chemical carcinogenesis_Homo sapiens_hsa052041.16724815
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16699227
46Protein digestion and absorption_Homo sapiens_hsa049741.13473670
47Glycerolipid metabolism_Homo sapiens_hsa005611.13199377
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10610908
49Vitamin digestion and absorption_Homo sapiens_hsa049771.06273171
50TGF-beta signaling pathway_Homo sapiens_hsa043501.05894820
51p53 signaling pathway_Homo sapiens_hsa041151.05163195
52Retinol metabolism_Homo sapiens_hsa008301.04818748
53Melanoma_Homo sapiens_hsa052181.03360011
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03060168
55Circadian rhythm_Homo sapiens_hsa047101.02798212
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01734603
57Small cell lung cancer_Homo sapiens_hsa052221.01617829
58Insulin resistance_Homo sapiens_hsa049310.99621478
59Staphylococcus aureus infection_Homo sapiens_hsa051500.97306875
60Phenylalanine metabolism_Homo sapiens_hsa003600.96056242
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.96044379
62Tyrosine metabolism_Homo sapiens_hsa003500.95724875
63Melanogenesis_Homo sapiens_hsa049160.95070819
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93099785
65Prion diseases_Homo sapiens_hsa050200.92996440
66Wnt signaling pathway_Homo sapiens_hsa043100.92606184
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.91274463
68Proteoglycans in cancer_Homo sapiens_hsa052050.89996526
69Dilated cardiomyopathy_Homo sapiens_hsa054140.89862243
70Starch and sucrose metabolism_Homo sapiens_hsa005000.89115851
71Glioma_Homo sapiens_hsa052140.87363843
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87268692
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86423507
74Amoebiasis_Homo sapiens_hsa051460.86394594
75Glucagon signaling pathway_Homo sapiens_hsa049220.85862303
76Dorso-ventral axis formation_Homo sapiens_hsa043200.85496832
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83619483
78ErbB signaling pathway_Homo sapiens_hsa040120.83199719
79Histidine metabolism_Homo sapiens_hsa003400.81965207
80Tight junction_Homo sapiens_hsa045300.81783387
81AMPK signaling pathway_Homo sapiens_hsa041520.81766663
82Gap junction_Homo sapiens_hsa045400.80669039
83Fatty acid elongation_Homo sapiens_hsa000620.80380245
84Ovarian steroidogenesis_Homo sapiens_hsa049130.79813257
85Hippo signaling pathway_Homo sapiens_hsa043900.79394921
86Biosynthesis of amino acids_Homo sapiens_hsa012300.78703363
87Endocytosis_Homo sapiens_hsa041440.78071369
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78064540
89ABC transporters_Homo sapiens_hsa020100.77680537
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70222613
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69145037
92Arginine and proline metabolism_Homo sapiens_hsa003300.69040987
93Sphingolipid metabolism_Homo sapiens_hsa006000.68834227
94Cell cycle_Homo sapiens_hsa041100.68823598
95N-Glycan biosynthesis_Homo sapiens_hsa005100.68757117
96Ras signaling pathway_Homo sapiens_hsa040140.67823126
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67057199
98Shigellosis_Homo sapiens_hsa051310.66092552
99Basal cell carcinoma_Homo sapiens_hsa052170.65540061
100Sulfur metabolism_Homo sapiens_hsa009200.63621133
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62769039
102Thyroid hormone synthesis_Homo sapiens_hsa049180.62361232
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61534144
104Endometrial cancer_Homo sapiens_hsa052130.60112257
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.59472559
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59387025
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.58406306
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58373304
109Estrogen signaling pathway_Homo sapiens_hsa049150.56074878
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.54189873
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.54085099
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51734681
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51204746
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.49867212
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49731373
116Colorectal cancer_Homo sapiens_hsa052100.48583282
117Prostate cancer_Homo sapiens_hsa052150.48571589
118MicroRNAs in cancer_Homo sapiens_hsa052060.47763433
119Salmonella infection_Homo sapiens_hsa051320.46964311
120FoxO signaling pathway_Homo sapiens_hsa040680.46048699
121Nucleotide excision repair_Homo sapiens_hsa034200.45619534
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45341834
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.45110956
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44499366
125Rap1 signaling pathway_Homo sapiens_hsa040150.43804305
126Inositol phosphate metabolism_Homo sapiens_hsa005620.43660172
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42818254
128HIF-1 signaling pathway_Homo sapiens_hsa040660.41969132
129Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41781696
130VEGF signaling pathway_Homo sapiens_hsa043700.40617402
131Oocyte meiosis_Homo sapiens_hsa041140.39737133
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38992130
133Vibrio cholerae infection_Homo sapiens_hsa051100.37995605
134Folate biosynthesis_Homo sapiens_hsa007900.37865790
135Choline metabolism in cancer_Homo sapiens_hsa052310.35630371
136Pathways in cancer_Homo sapiens_hsa052000.35605300
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35100404
138Viral myocarditis_Homo sapiens_hsa054160.34827693
139Pentose phosphate pathway_Homo sapiens_hsa000300.34651633
140Bladder cancer_Homo sapiens_hsa052190.34503177
141Insulin signaling pathway_Homo sapiens_hsa049100.34396375
142GnRH signaling pathway_Homo sapiens_hsa049120.33105935
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.32653394
144Renal cell carcinoma_Homo sapiens_hsa052110.31344241
145Hedgehog signaling pathway_Homo sapiens_hsa043400.28918900
146Platelet activation_Homo sapiens_hsa046110.28689457
147cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28661268

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »