ARHGAP30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.51439433
2antigen processing and presentation of endogenous antigen (GO:0019883)5.73599533
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.69973597
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.69973597
5negative regulation of cell killing (GO:0031342)5.12615796
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.12615796
7regulation of B cell receptor signaling pathway (GO:0050855)5.09667510
8regulation of gamma-delta T cell differentiation (GO:0045586)4.90598401
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.85822734
10detection of other organism (GO:0098543)4.76794992
11regulation of gamma-delta T cell activation (GO:0046643)4.68040286
12detection of bacterium (GO:0016045)4.63404578
13B cell receptor signaling pathway (GO:0050853)4.58034124
14positive thymic T cell selection (GO:0045059)4.55368745
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.51449210
16positive regulation of B cell differentiation (GO:0045579)4.48706366
17negative T cell selection (GO:0043383)4.47870655
18negative thymic T cell selection (GO:0045060)4.43726505
19regulation of B cell differentiation (GO:0045577)4.32642399
20negative regulation of lymphocyte mediated immunity (GO:0002707)4.17637497
21regulation of interferon-beta biosynthetic process (GO:0045357)4.00695703
22leukocyte aggregation (GO:0070486)3.98033219
23detection of external biotic stimulus (GO:0098581)3.94603418
24T cell migration (GO:0072678)3.93107474
25regulation of interleukin-12 biosynthetic process (GO:0045075)3.90199144
26negative regulation of T cell mediated immunity (GO:0002710)3.89653479
27response to interleukin-15 (GO:0070672)3.84097590
28positive T cell selection (GO:0043368)3.83708824
29positive regulation by symbiont of host defense response (GO:0052509)3.80455038
30modulation by symbiont of host defense response (GO:0052031)3.80455038
31modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.80455038
32modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.80455038
33positive regulation by organism of defense response of other organism involved in symbiotic interact3.80455038
34modulation by symbiont of host immune response (GO:0052553)3.80455038
35NIK/NF-kappaB signaling (GO:0038061)3.78955109
36interferon-gamma production (GO:0032609)3.77833031
37negative regulation of leukocyte mediated immunity (GO:0002704)3.76390704
38thymic T cell selection (GO:0045061)3.76286187
39T cell selection (GO:0045058)3.72159822
40positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.63487905
41response to host immune response (GO:0052572)3.59012550
42response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.59012550
43neutrophil activation involved in immune response (GO:0002283)3.58977839
44detection of molecule of bacterial origin (GO:0032490)3.56602485
45tolerance induction (GO:0002507)3.56409484
46immunoglobulin mediated immune response (GO:0016064)3.54099912
47regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.52263661
48negative regulation of erythrocyte differentiation (GO:0045647)3.52211713
49cellular response to interleukin-15 (GO:0071350)3.52014241
50positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.51670490
51detection of biotic stimulus (GO:0009595)3.47018603
52regulation of mast cell degranulation (GO:0043304)3.45241276
53microglial cell activation (GO:0001774)3.45195171
54positive regulation of interferon-alpha production (GO:0032727)3.42602893
55regulation of alpha-beta T cell proliferation (GO:0046640)3.38838156
56regulation of tolerance induction (GO:0002643)3.37159007
57regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.36643604
58antigen receptor-mediated signaling pathway (GO:0050851)3.35469250
59response to host (GO:0075136)3.32447825
60response to host defenses (GO:0052200)3.32447825
61response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.32447825
62neutrophil activation (GO:0042119)3.32025175
63positive regulation of antigen processing and presentation (GO:0002579)3.30996621
64positive regulation of mast cell activation (GO:0033005)3.30167647
65regulation of interferon-alpha production (GO:0032647)3.30048197
66mature B cell differentiation (GO:0002335)3.29094211
67respiratory burst (GO:0045730)3.24741905
68myeloid dendritic cell activation (GO:0001773)3.23975423
69regulation of T cell tolerance induction (GO:0002664)3.22742394
70negative regulation of phagocytosis (GO:0050765)3.21565391
71cellular extravasation (GO:0045123)3.21108947
72negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.20953706
73regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.19596601
74regulation of myeloid leukocyte mediated immunity (GO:0002886)3.18972698
75positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.17649749
76macrophage activation (GO:0042116)3.16853476
77regulation of mast cell activation involved in immune response (GO:0033006)3.15688540
78mast cell activation (GO:0045576)3.14279151
79Arp2/3 complex-mediated actin nucleation (GO:0034314)3.14072337
80interferon-gamma-mediated signaling pathway (GO:0060333)3.13464036
81leukocyte migration involved in inflammatory response (GO:0002523)3.13013474
82regulation of natural killer cell mediated immunity (GO:0002715)3.12798574
83regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.12798574
84B cell homeostasis (GO:0001782)3.12152118
85neutrophil mediated immunity (GO:0002446)3.11227535
86regulation of leukocyte degranulation (GO:0043300)3.11027127
87positive regulation of granulocyte differentiation (GO:0030854)3.09005119
88positive regulation of interleukin-2 production (GO:0032743)3.08697102
89granulocyte activation (GO:0036230)3.08505926
90T cell homeostasis (GO:0043029)3.08096501
91response to type I interferon (GO:0034340)3.06719338
92macrophage activation involved in immune response (GO:0002281)3.06403146
93regulation of T cell mediated cytotoxicity (GO:0001914)3.05470490
94lymphocyte homeostasis (GO:0002260)3.05367817
95regulation of mast cell activation (GO:0033003)3.05347306
96negative regulation of B cell proliferation (GO:0030889)3.04321641
97cellular response to zinc ion (GO:0071294)3.02850967
98negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.02715956
99T cell costimulation (GO:0031295)3.01769935
100defense response to protozoan (GO:0042832)3.01174910
101leukocyte degranulation (GO:0043299)3.00795922
102regulation of dendritic cell antigen processing and presentation (GO:0002604)3.00291888
103germinal center formation (GO:0002467)3.00253689
104negative regulation of innate immune response (GO:0045824)3.00022592
105cellular response to type I interferon (GO:0071357)2.99637744
106type I interferon signaling pathway (GO:0060337)2.99637744
107response to muramyl dipeptide (GO:0032495)2.99592831
108myeloid cell activation involved in immune response (GO:0002275)2.99484641
109regulation of T cell receptor signaling pathway (GO:0050856)2.99322820
110T cell receptor signaling pathway (GO:0050852)2.99088269
111negative regulation of interleukin-12 production (GO:0032695)2.98296725
112activated T cell proliferation (GO:0050798)2.97938165
113antigen processing and presentation via MHC class Ib (GO:0002475)2.96658010
114lymphocyte costimulation (GO:0031294)2.95524276
115leukocyte cell-cell adhesion (GO:0007159)2.95250931
116B cell proliferation (GO:0042100)2.94840985
117myeloid dendritic cell differentiation (GO:0043011)2.94717496
118JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.94093327
119production of molecular mediator involved in inflammatory response (GO:0002532)2.93884908
120response to protozoan (GO:0001562)2.91913932
121positive regulation of T cell mediated cytotoxicity (GO:0001916)2.90570550
122regulation of B cell proliferation (GO:0030888)2.88452510
123positive regulation of isotype switching (GO:0045830)2.87893682
124T cell proliferation (GO:0042098)2.87405140
125regulation of regulatory T cell differentiation (GO:0045589)2.85762869
126positive regulation of tolerance induction (GO:0002645)2.84992033
127regulation of interleukin-2 biosynthetic process (GO:0045076)2.84629080
128positive regulation of alpha-beta T cell proliferation (GO:0046641)2.83748719
129regulation of type I interferon-mediated signaling pathway (GO:0060338)2.82858979
130regulation of antigen processing and presentation (GO:0002577)2.82460491
131positive regulation of B cell activation (GO:0050871)2.81634371
132response to peptidoglycan (GO:0032494)2.80066518
133positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.78924728
134immune response-activating cell surface receptor signaling pathway (GO:0002429)2.78274373
135B cell mediated immunity (GO:0019724)2.77587394
136natural killer cell mediated immunity (GO:0002228)2.76487532
137natural killer cell mediated cytotoxicity (GO:0042267)2.76487532
138natural killer cell differentiation (GO:0001779)2.74012678
139regulation of response to interferon-gamma (GO:0060330)2.72957734

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.35055745
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.17290958
3E2F7_22180533_ChIP-Seq_HELA_Human4.58258711
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.29387710
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.27699783
6* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.82682335
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.55053810
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.40534847
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.25757589
10MYC_22102868_ChIP-Seq_BL_Human3.20847730
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.19016276
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.07412793
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.98587895
14* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.96773255
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.95528891
16VDR_21846776_ChIP-Seq_THP-1_Human2.82308964
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.79124006
18MYB_26560356_Chip-Seq_TH2_Human2.69103645
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.68829436
20RUNX_20019798_ChIP-Seq_JUKART_Human2.67584830
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.65664595
22* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.62910906
23* MAF_26560356_Chip-Seq_TH1_Human2.49169495
24SCL_19346495_ChIP-Seq_HPC-7_Human2.44792234
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42673309
26* MYB_26560356_Chip-Seq_TH1_Human2.38714361
27* SPI1_23547873_ChIP-Seq_NB4_Human2.35489162
28* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26553422
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.18344661
30VDR_24763502_ChIP-Seq_THP-1_Human2.16378422
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.14467642
32* UTX_26944678_Chip-Seq_JUKART_Human2.13558207
33* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08037833
34* RUNX1_22412390_ChIP-Seq_EML_Mouse2.03985161
35FOXM1_23109430_ChIP-Seq_U2OS_Human2.00491976
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.97254612
37* TCF7_22412390_ChIP-Seq_EML_Mouse1.95534834
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83758453
39SPI1_23127762_ChIP-Seq_K562_Human1.82072598
40* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68458603
41GATA3_27048872_Chip-Seq_THYMUS_Human1.66677734
42* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.63314039
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62528653
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62368850
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58830472
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.57232302
47* MAF_26560356_Chip-Seq_TH2_Human1.57103429
48* PU_27001747_Chip-Seq_BMDM_Mouse1.55516230
49* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50800280
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47115731
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46069583
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.44628656
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43732302
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42627302
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42556151
56* KDM2B_26808549_Chip-Seq_DND41_Human1.41408309
57CIITA_25753668_ChIP-Seq_RAJI_Human1.39954713
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39874123
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.35230832
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34624854
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28920972
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28846656
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27479551
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27082565
65GATA1_22025678_ChIP-Seq_K562_Human1.26711589
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25433692
67LXR_22292898_ChIP-Seq_THP-1_Human1.22738322
68GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22241383
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19124266
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18933499
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16651452
72GATA1_19941826_ChIP-Seq_K562_Human1.15929482
73* GATA3_26560356_Chip-Seq_TH2_Human1.15453211
74* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15292012
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.13919578
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13122118
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11116699
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08714709
79* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08049711
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04129535
81BCL6_27268052_Chip-Seq_Bcells_Human1.04045966
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02488572
83VDR_24787735_ChIP-Seq_THP-1_Human1.00384789
84GATA1_19941827_ChIP-Seq_MEL_Mouse0.98809686
85BCOR_27268052_Chip-Seq_Bcells_Human0.98423956
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97047089
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95091496
88SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95088111
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94594038
90PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93986731
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93020574
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92953572
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92014312
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91792252
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91741495
96TFEB_21752829_ChIP-Seq_HELA_Human0.91299070
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88858004
98GATA2_19941826_ChIP-Seq_K562_Human0.86801742
99NCOR1_26117541_ChIP-Seq_K562_Human0.86111412
100* IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85070498
101* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84995922
102VDR_23849224_ChIP-Seq_CD4+_Human0.84944103
103FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.83246393
104PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82464536
105ELF1_20517297_ChIP-Seq_JURKAT_Human0.82286361
106EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.80599165
107SPI1_20517297_ChIP-Seq_HL60_Human0.80383375
108E2F1_21310950_ChIP-Seq_MCF-7_Human0.80253134
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80242051
110GATA2_21666600_ChIP-Seq_HMVEC_Human0.80210046
111FOXP3_21729870_ChIP-Seq_TREG_Human0.79545260
112SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.79085173
113KDM2B_26808549_Chip-Seq_JURKAT_Human0.76087782
114ETS1_22383799_ChIP-Seq_G1ME_Mouse0.73234951
115* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71781534
116* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67578589
117GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67430363

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.50371530
2MP0001800_abnormal_humoral_immune3.42200903
3MP0000685_abnormal_immune_system3.35737637
4MP0001790_abnormal_immune_system3.34384583
5MP0005387_immune_system_phenotype3.34384583
6MP0005671_abnormal_response_to3.32149195
7MP0005000_abnormal_immune_tolerance2.98341694
8MP0002452_abnormal_antigen_presenting2.97340508
9MP0003303_peritoneal_inflammation2.89581435
10MP0003436_decreased_susceptibility_to2.87370535
11MP0003763_abnormal_thymus_physiology2.86876516
12MP0002723_abnormal_immune_serum2.78857941
13MP0002420_abnormal_adaptive_immunity2.73811084
14MP0001819_abnormal_immune_cell2.71336599
15MP0009785_altered_susceptibility_to2.62836373
16MP0005025_abnormal_response_to2.56328557
17MP0002166_altered_tumor_susceptibility2.54889870
18MP0002419_abnormal_innate_immunity2.54839685
19MP0002398_abnormal_bone_marrow2.52227263
20MP0002396_abnormal_hematopoietic_system2.50525273
21MP0002148_abnormal_hypersensitivity_rea2.33958025
22MP0000716_abnormal_immune_system2.30702748
23MP0002405_respiratory_system_inflammati2.17232179
24MP0000689_abnormal_spleen_morphology2.14887114
25MP0003300_gastrointestinal_ulcer2.12408843
26MP0001873_stomach_inflammation2.08822947
27MP0000569_abnormal_digit_pigmentation2.07948158
28MP0005464_abnormal_platelet_physiology2.06695610
29MP0002006_tumorigenesis2.03223185
30MP0006082_CNS_inflammation2.02943819
31MP0002722_abnormal_immune_system2.02937338
32MP0004510_myositis1.94523784
33MP0002429_abnormal_blood_cell1.91349484
34MP0009333_abnormal_splenocyte_physiolog1.90721740
35MP0004808_abnormal_hematopoietic_stem1.85938159
36MP0010155_abnormal_intestine_physiology1.85060489
37MP0000703_abnormal_thymus_morphology1.83436739
38MP0004947_skin_inflammation1.82647348
39MP0005174_abnormal_tail_pigmentation1.81888399
40MP0001853_heart_inflammation1.78039588
41MP0001845_abnormal_inflammatory_respons1.74566569
42MP0009278_abnormal_bone_marrow1.70555823
43MP0008260_abnormal_autophagy1.67698265
44MP0005058_abnormal_lysosome_morphology1.62344150
45MP0003172_abnormal_lysosome_physiology1.55299310
46MP0005397_hematopoietic_system_phenotyp1.51857240
47MP0001545_abnormal_hematopoietic_system1.51857240
48MP0000465_gastrointestinal_hemorrhage1.51402253
49MP0003724_increased_susceptibility_to1.49494427
50MP0005451_abnormal_body_composition1.48469967
51MP0005310_abnormal_salivary_gland1.45843950
52MP0003866_abnormal_defecation1.39299751
53MP0002933_joint_inflammation1.37781498
54MP0003183_abnormal_peptide_metabolism1.37389214
55MP0001533_abnormal_skeleton_physiology1.30213483
56MP0000015_abnormal_ear_pigmentation1.29549386
57MP0003448_altered_tumor_morphology1.27364207
58MP0008469_abnormal_protein_level1.25036357
59MP0010307_abnormal_tumor_latency1.24103626
60MP0000858_altered_metastatic_potential1.21909211
61MP0004883_abnormal_blood_vessel1.20636212
62MP0000490_abnormal_crypts_of1.18244577
63MP0008057_abnormal_DNA_replication1.10895345
64MP0003690_abnormal_glial_cell1.07502862
65MP0003191_abnormal_cellular_cholesterol1.06929404
66MP0010352_gastrointestinal_tract_polyps1.05532164
67MP0005076_abnormal_cell_differentiation1.04801305
68MP0005075_abnormal_melanosome_morpholog1.01069374
69MP0002019_abnormal_tumor_incidence0.96905197
70MP0000371_diluted_coat_color0.92625559
71MP0002138_abnormal_hepatobiliary_system0.91483397
72MP0001851_eye_inflammation0.91125922
73MP0002998_abnormal_bone_remodeling0.90951486
74MP0002095_abnormal_skin_pigmentation0.87554250
75MP0005164_abnormal_response_to0.84733376
76MP0010094_abnormal_chromosome_stability0.82549098
77MP0009764_decreased_sensitivity_to0.82297256
78MP0003077_abnormal_cell_cycle0.81592721
79MP0002009_preneoplasia0.80461349
80MP0001986_abnormal_taste_sensitivity0.75438351
81MP0005390_skeleton_phenotype0.73653339
82MP0003656_abnormal_erythrocyte_physiolo0.72010217
83MP0003566_abnormal_cell_adhesion0.71869591
84MP0003693_abnormal_embryo_hatching0.70485408
85MP0009840_abnormal_foam_cell0.69525426
86MP0003828_pulmonary_edema0.69522095
87MP0009763_increased_sensitivity_to0.67503335
88MP0002277_abnormal_respiratory_mucosa0.67492748
89MP0000343_altered_response_to0.65872848
90MP0003091_abnormal_cell_migration0.63672989
91MP0002132_abnormal_respiratory_system0.63669028
92MP0003045_fibrosis0.62665499
93MP0004381_abnormal_hair_follicle0.61275463
94MP0009765_abnormal_xenobiotic_induced0.61129240
95MP0005166_decreased_susceptibility_to0.60892735
96MP0001663_abnormal_digestive_system0.60252866
97MP0003111_abnormal_nucleus_morphology0.59876787
98MP0008004_abnormal_stomach_pH0.59080617
99MP0000604_amyloidosis0.58915958
100MP0002136_abnormal_kidney_physiology0.58527830
101MP0003453_abnormal_keratinocyte_physiol0.58380071
102MP0000313_abnormal_cell_death0.57808503
103MP0008874_decreased_physiological_sensi0.57150329
104MP0000249_abnormal_blood_vessel0.56736240
105MP0003221_abnormal_cardiomyocyte_apopto0.56249764
106MP0005023_abnormal_wound_healing0.56195983
107MP0008007_abnormal_cellular_replicative0.53355789
108MP0008961_abnormal_basal_metabolism0.51992016
109MP0003795_abnormal_bone_structure0.51685654
110MP0004130_abnormal_muscle_cell0.50754529
111MP0002928_abnormal_bile_duct0.50353689
112MP0002693_abnormal_pancreas_physiology0.50208310
113MP0003806_abnormal_nucleotide_metabolis0.48840609
114MP0005621_abnormal_cell_physiology0.48375417
115MP0003075_altered_response_to0.47858518
116MP0000609_abnormal_liver_physiology0.45094661
117MP0005381_digestive/alimentary_phenotyp0.44871231
118MP0009115_abnormal_fat_cell0.43814015
119MP0005388_respiratory_system_phenotype0.42137038
120MP0002133_abnormal_respiratory_system0.42137038

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.33069610
2Eczematoid dermatitis (HP:0000976)4.92553071
3Recurrent bacterial skin infections (HP:0005406)4.89376708
4Recurrent viral infections (HP:0004429)4.85942994
5Recurrent fungal infections (HP:0002841)4.65732150
6Agammaglobulinemia (HP:0004432)4.16336825
7Myositis (HP:0100614)4.09275418
8Panhypogammaglobulinemia (HP:0003139)4.08240853
9Chronic otitis media (HP:0000389)4.07073886
10IgM deficiency (HP:0002850)4.06519906
11Recurrent bronchitis (HP:0002837)4.05006259
12T lymphocytopenia (HP:0005403)4.03514551
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.94481131
14Elevated erythrocyte sedimentation rate (HP:0003565)3.90722340
15Abnormality of T cell number (HP:0011839)3.90514379
16Meningitis (HP:0001287)3.83279669
17Cellulitis (HP:0100658)3.80457547
18Chronic mucocutaneous candidiasis (HP:0002728)3.77022510
19Recurrent cutaneous fungal infections (HP:0011370)3.77022510
20Inflammation of the large intestine (HP:0002037)3.76058484
21Colitis (HP:0002583)3.68274707
22Recurrent skin infections (HP:0001581)3.66220500
23Mediastinal lymphadenopathy (HP:0100721)3.61996345
24Gastrointestinal inflammation (HP:0004386)3.61996039
25Vasculitis (HP:0002633)3.42865199
26Abnormality of T cells (HP:0002843)3.42791928
27Abnormality of the fingertips (HP:0001211)3.32097177
28Thyroiditis (HP:0100646)3.30873704
29Recurrent gram-negative bacterial infections (HP:0005420)3.30275881
30Retrobulbar optic neuritis (HP:0100654)3.28717692
31Optic neuritis (HP:0100653)3.28717692
32Urticaria (HP:0001025)3.25848726
33B lymphocytopenia (HP:0010976)3.24362458
34Abnormality of B cell number (HP:0010975)3.24362458
35Nasal polyposis (HP:0100582)3.23877352
36Chronic obstructive pulmonary disease (HP:0006510)3.21904962
37Obstructive lung disease (HP:0006536)3.21904962
38Spontaneous hematomas (HP:0007420)3.16036866
39Orchitis (HP:0100796)3.15994664
40Pustule (HP:0200039)3.14957297
41Abnormality of macrophages (HP:0004311)3.12543024
42Gastrointestinal stroma tumor (HP:0100723)3.10793061
43Autoimmune thrombocytopenia (HP:0001973)3.07156112
44Lymphopenia (HP:0001888)3.04489867
45Eosinophilia (HP:0001880)3.00066334
46Abnormality of cells of the lymphoid lineage (HP:0012140)2.94732535
47Thrombocytosis (HP:0001894)2.94236263
48Verrucae (HP:0200043)2.89934717
49Papilloma (HP:0012740)2.89934717
50Abnormality of T cell physiology (HP:0011840)2.86146933
51Hypochromic anemia (HP:0001931)2.83885011
52Recurrent sinusitis (HP:0011108)2.83294432
53Severe combined immunodeficiency (HP:0004430)2.78183511
54Stomatitis (HP:0010280)2.77406551
55Abnormality of the nasal mucosa (HP:0000433)2.76946191
56Leukocytosis (HP:0001974)2.75820286
57Osteomyelitis (HP:0002754)2.75047316
58Periodontitis (HP:0000704)2.72879715
59Hypochromic microcytic anemia (HP:0004840)2.71780106
60Increased IgM level (HP:0003496)2.71539771
61Pulmonary infiltrates (HP:0002113)2.70211418
62IgG deficiency (HP:0004315)2.69147011
63Gingivitis (HP:0000230)2.68950274
64Granulocytopenia (HP:0001913)2.68726005
65Chronic diarrhea (HP:0002028)2.68013375
66Encephalitis (HP:0002383)2.67014861
67Increased IgE level (HP:0003212)2.66090277
68Combined immunodeficiency (HP:0005387)2.66027585
69Arterial thrombosis (HP:0004420)2.64413753
70IgA deficiency (HP:0002720)2.58683337
71Abnormality of eosinophils (HP:0001879)2.57780800
72Pulmonary embolism (HP:0002204)2.53274414
73Chronic sinusitis (HP:0011109)2.51327868
74Recurrent pneumonia (HP:0006532)2.48836491
75Emphysema (HP:0002097)2.47005403
76Prolonged bleeding time (HP:0003010)2.42989466
77Hematochezia (HP:0002573)2.42464359
78Episodic fever (HP:0001954)2.41981882
79Autoimmune hemolytic anemia (HP:0001890)2.38940827
80Anorexia (HP:0002039)2.38609307
81Hemoptysis (HP:0002105)2.36441891
82Recurrent lower respiratory tract infections (HP:0002783)2.32042333
83Vacuolated lymphocytes (HP:0001922)2.31676452
84Chest pain (HP:0100749)2.31109049
85Lymphoma (HP:0002665)2.30516504
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.30453912
87Petechiae (HP:0000967)2.29534033
88Gingival bleeding (HP:0000225)2.29501394
89Interstitial pulmonary disease (HP:0006530)2.26693407
90Keratoconjunctivitis sicca (HP:0001097)2.26321410
91Viral hepatitis (HP:0006562)2.25675777
92Abnormality of the pleura (HP:0002103)2.22558219
93Sepsis (HP:0100806)2.19499985
94Bronchitis (HP:0012387)2.17869701
95Epistaxis (HP:0000421)2.17400135
96Microcytic anemia (HP:0001935)2.15470349
97Gangrene (HP:0100758)2.13949577
98Restrictive lung disease (HP:0002091)2.13685852
99Skin ulcer (HP:0200042)2.12094949
100Slow saccadic eye movements (HP:0000514)2.12049839
101Amyloidosis (HP:0011034)2.10485656
102Abnormality of glycolipid metabolism (HP:0010969)2.09668551
103Abnormality of liposaccharide metabolism (HP:0010968)2.09668551
104Abnormality of glycosphingolipid metabolism (HP:0004343)2.09668551
105Keratoconjunctivitis (HP:0001096)2.06001370
106Purpura (HP:0000979)2.05747244
107Leukopenia (HP:0001882)2.04961364
108Papilledema (HP:0001085)2.02390371
109Glomerulopathy (HP:0100820)2.01771051
110Loss of speech (HP:0002371)2.00128621
111Abnormality of the peritoneum (HP:0002585)2.00048696
112Systemic lupus erythematosus (HP:0002725)1.98778019
113Increased cerebral lipofuscin (HP:0011813)1.98543785
114Abnormality of the prostate (HP:0008775)1.98169194
115Premature loss of primary teeth (HP:0006323)1.98047082
116Gastrointestinal infarctions (HP:0005244)1.97263646
117Hypergammaglobulinemia (HP:0010702)1.96212204
118Abnormal platelet function (HP:0011869)1.95660454
119Impaired platelet aggregation (HP:0003540)1.95660454
120Peritonitis (HP:0002586)1.94652476
121Skin rash (HP:0000988)1.92438951
122Hypoplasia of the thymus (HP:0000778)1.91428484
123Myocardial infarction (HP:0001658)1.91114390
124Abnormality of the endocardium (HP:0004306)1.90896823
125Increased serum ferritin (HP:0003281)1.90778397
126Abnormal platelet volume (HP:0011876)1.90165667
127Fatigue (HP:0012378)1.89072094
128Cheilitis (HP:0100825)1.86586475

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.27946149
2PRPF4B3.03144616
3TYK22.97433071
4TXK2.95775329
5MAP3K142.73663629
6JAK32.58149939
7BLK2.47663227
8IRAK42.46784952
9STK102.32628295
10KIT2.22687062
11ZAP702.20674466
12BTK2.12249190
13JAK12.09214346
14GRK62.08298270
15CSF1R2.05726704
16MAP3K102.02902955
17ITK2.01236739
18IKBKE2.00718106
19TBK12.00369834
20SYK1.99927442
21RIPK41.92074096
22MAP3K131.91189974
23SIK21.83592778
24EEF2K1.76129472
25TEC1.69292081
26IKBKB1.66628723
27HCK1.65214812
28CSK1.60194628
29LCK1.56696987
30CDK121.51146300
31FGFR31.48584522
32FGFR41.46220391
33TGFBR21.45549600
34IRAK31.44341040
35ERN11.41858462
36FES1.41611656
37TAOK11.35851948
38MAP3K31.32447346
39LRRK21.29721693
40MARK31.28065804
41TAOK31.27146013
42PIM11.26046679
43CLK11.25811320
44EPHB11.22003382
45LYN1.20827625
46MAP3K111.20104113
47CHUK1.08435625
48MAP3K11.07052231
49PKN21.00382685
50KSR20.96730670
51STK40.96556798
52RPS6KA40.96035409
53MARK20.95965504
54SMG10.93399640
55NLK0.91833229
56JAK20.90091953
57NEK20.89448042
58MAP2K30.89098737
59BMPR20.88560958
60PRKCQ0.82883716
61CDK40.82288610
62FLT30.80477784
63SIK30.78799143
64PRKD20.76850873
65CAMK1D0.76706944
66TRIB30.73051737
67CDK60.72775799
68TTN0.70407947
69CDC42BPA0.69933566
70TNK20.69507917
71TAOK20.68837924
72PDPK10.68296489
73CAMKK10.67373247
74NEK90.65442503
75MST40.64771717
76CAMK1G0.63897865
77BRD40.61468367
78IRAK20.59922766
79PTK60.59351588
80CAMKK20.58651823
81HIPK20.58439459
82PASK0.57750594
83TRPM70.57472404
84PIK3CG0.55623809
85ALK0.52527096
86CDK90.52395589
87EPHA30.50401636
88PRKCH0.49150044
89MAP3K60.49079247
90FGR0.48872424
91CDK190.47080578
92NME20.46298964
93PDK10.45439075
94ABL10.44463836
95MAP3K80.43843023
96EGFR0.43626731
97YES10.41983367
98DYRK1B0.41831367
99MAP3K70.41798928
100MAPKAPK20.41632640
101STK110.40935391
102SIK10.40897094
103ATR0.40854003
104RPS6KA60.38616128
105GRK70.38306166
106MATK0.37521473
107RET0.37225726
108MELK0.37176694
109TESK20.37074183
110MAPK40.36479571
111MAP3K50.36275609
112MAP2K20.35343157
113MAPK110.35036867
114RAF10.33247704
115PIM20.32851734
116FYN0.32287640
117PDGFRB0.31961222
118MAP3K20.31365713
119SCYL20.30365800
120PTK2B0.29890300
121MAPK70.29770800
122CDC70.29604785
123SGK30.29589426
124RPS6KA50.29020326
125RPS6KC10.28941857
126RPS6KL10.28941857
127STK380.28710980
128PRKCD0.27927214
129IRAK10.27517988
130MAPK120.25122229
131STK240.24739768

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.00966619
2B cell receptor signaling pathway_Homo sapiens_hsa046623.06798760
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.78965773
4Leishmaniasis_Homo sapiens_hsa051402.69088086
5Osteoclast differentiation_Homo sapiens_hsa043802.49709286
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.46552010
7Measles_Homo sapiens_hsa051622.39531502
8Antigen processing and presentation_Homo sapiens_hsa046122.38384874
9T cell receptor signaling pathway_Homo sapiens_hsa046602.22517510
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.21920876
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.19463542
12Hematopoietic cell lineage_Homo sapiens_hsa046402.08330504
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.90887133
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.88186337
15Allograft rejection_Homo sapiens_hsa053301.79854951
16Graft-versus-host disease_Homo sapiens_hsa053321.77346811
17Staphylococcus aureus infection_Homo sapiens_hsa051501.72423089
18Herpes simplex infection_Homo sapiens_hsa051681.71325968
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.70468481
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69712935
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.61207503
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.60376177
23Toxoplasmosis_Homo sapiens_hsa051451.56254830
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56192277
25Tuberculosis_Homo sapiens_hsa051521.55766681
26Chemokine signaling pathway_Homo sapiens_hsa040621.52063529
27Influenza A_Homo sapiens_hsa051641.51471624
28Hepatitis B_Homo sapiens_hsa051611.40347473
29Apoptosis_Homo sapiens_hsa042101.39780213
30Acute myeloid leukemia_Homo sapiens_hsa052211.37008555
31Pertussis_Homo sapiens_hsa051331.35788053
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.31205594
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31104374
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30908575
35Legionellosis_Homo sapiens_hsa051341.29361504
36Viral myocarditis_Homo sapiens_hsa054161.28021888
37Chronic myeloid leukemia_Homo sapiens_hsa052201.27704265
38TNF signaling pathway_Homo sapiens_hsa046681.25946514
39Shigellosis_Homo sapiens_hsa051311.25615855
40Malaria_Homo sapiens_hsa051441.23376623
41Other glycan degradation_Homo sapiens_hsa005111.23206573
42Epstein-Barr virus infection_Homo sapiens_hsa051691.09378420
43Pancreatic cancer_Homo sapiens_hsa052121.08677018
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.07115789
45Non-homologous end-joining_Homo sapiens_hsa034501.06323394
46Autoimmune thyroid disease_Homo sapiens_hsa053201.04595163
47Asthma_Homo sapiens_hsa053101.03614975
48Platelet activation_Homo sapiens_hsa046111.03441675
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01126925
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00456051
51Viral carcinogenesis_Homo sapiens_hsa052030.96806545
52Hepatitis C_Homo sapiens_hsa051600.92802297
53Salmonella infection_Homo sapiens_hsa051320.91343421
54DNA replication_Homo sapiens_hsa030300.91149388
55Lysosome_Homo sapiens_hsa041420.89095033
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87815008
57HTLV-I infection_Homo sapiens_hsa051660.87438788
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87092084
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85753623
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.85127593
61Base excision repair_Homo sapiens_hsa034100.83142348
62Non-small cell lung cancer_Homo sapiens_hsa052230.83043423
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82084381
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80842855
65Small cell lung cancer_Homo sapiens_hsa052220.76386946
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72401253
67Prolactin signaling pathway_Homo sapiens_hsa049170.70267020
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68536032
69Type I diabetes mellitus_Homo sapiens_hsa049400.64839629
70Rheumatoid arthritis_Homo sapiens_hsa053230.64623504
71Mismatch repair_Homo sapiens_hsa034300.64615628
72Endometrial cancer_Homo sapiens_hsa052130.62804058
73African trypanosomiasis_Homo sapiens_hsa051430.62269757
74Colorectal cancer_Homo sapiens_hsa052100.62156326
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.61367804
76Notch signaling pathway_Homo sapiens_hsa043300.60970728
77p53 signaling pathway_Homo sapiens_hsa041150.60146958
78VEGF signaling pathway_Homo sapiens_hsa043700.58434281
79Dorso-ventral axis formation_Homo sapiens_hsa043200.58352515
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56379914
81Choline metabolism in cancer_Homo sapiens_hsa052310.55868270
82GnRH signaling pathway_Homo sapiens_hsa049120.53809025
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51942040
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.51830039
85Phagosome_Homo sapiens_hsa041450.50700844
86MicroRNAs in cancer_Homo sapiens_hsa052060.48795058
87Endocytosis_Homo sapiens_hsa041440.48261997
88Systemic lupus erythematosus_Homo sapiens_hsa053220.47773114
89FoxO signaling pathway_Homo sapiens_hsa040680.47590569
90Inositol phosphate metabolism_Homo sapiens_hsa005620.47288292
91Homologous recombination_Homo sapiens_hsa034400.46108407
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46093221
93Caffeine metabolism_Homo sapiens_hsa002320.45544188
94Spliceosome_Homo sapiens_hsa030400.44750807
95HIF-1 signaling pathway_Homo sapiens_hsa040660.44589397
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44152222
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43797745
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42554415
99mTOR signaling pathway_Homo sapiens_hsa041500.40967177
100Insulin resistance_Homo sapiens_hsa049310.40581866
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.40253956
102Prostate cancer_Homo sapiens_hsa052150.39240332
103Amoebiasis_Homo sapiens_hsa051460.39018634
104Type II diabetes mellitus_Homo sapiens_hsa049300.36496195
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35369347
106Ribosome_Homo sapiens_hsa030100.34844889
107ErbB signaling pathway_Homo sapiens_hsa040120.34752438
108MAPK signaling pathway_Homo sapiens_hsa040100.34706131
109Fanconi anemia pathway_Homo sapiens_hsa034600.34636169
110Lysine degradation_Homo sapiens_hsa003100.34562481
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.32015270
112Cell cycle_Homo sapiens_hsa041100.31307327
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31059541
114Glioma_Homo sapiens_hsa052140.30743747
115Rap1 signaling pathway_Homo sapiens_hsa040150.30407724
116Renal cell carcinoma_Homo sapiens_hsa052110.29034965
117Estrogen signaling pathway_Homo sapiens_hsa049150.28504431
118Regulation of autophagy_Homo sapiens_hsa041400.27540887
119Proteoglycans in cancer_Homo sapiens_hsa052050.27364411
120Pathways in cancer_Homo sapiens_hsa052000.26594752
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26372697

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