ARHGAP31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a GTPase-activating protein (GAP). A variety of cellular processes are regulated by Rho GTPases which cycle between an inactive form bound to GDP and an active form bound to GTP. This cycling between inactive and active forms is regulated by guanine nucleotide exchange factors and GAPs. The encoded protein is a GAP shown to regulate two GTPases involved in protein trafficking and cell growth. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vascular endothelial growth factor signaling pathway (GO:0038084)4.28461940
2positive regulation by symbiont of host defense response (GO:0052509)3.77319055
3modulation by symbiont of host defense response (GO:0052031)3.77319055
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.77319055
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.77319055
6positive regulation by organism of defense response of other organism involved in symbiotic interact3.77319055
7modulation by symbiont of host immune response (GO:0052553)3.77319055
8negative regulation of interleukin-12 production (GO:0032695)3.68283741
9regulation of vitamin D biosynthetic process (GO:0060556)3.51516438
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.50550671
11surfactant homeostasis (GO:0043129)3.43022899
12regulation of mononuclear cell migration (GO:0071675)3.42942112
13positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.33723560
14lymph vessel development (GO:0001945)3.29790470
15protein localization to endosome (GO:0036010)3.25795385
16cellular response to thyroid hormone stimulus (GO:0097067)3.25702895
17fibroblast migration (GO:0010761)3.23607501
18cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.23119085
19retina vasculature morphogenesis in camera-type eye (GO:0061299)3.19911749
20virion attachment to host cell (GO:0019062)3.16386508
21adhesion of symbiont to host cell (GO:0044650)3.16386508
22response to muramyl dipeptide (GO:0032495)3.12896753
23barbed-end actin filament capping (GO:0051016)3.06700353
24regulation of dendritic cell antigen processing and presentation (GO:0002604)3.04012017
25germinal center formation (GO:0002467)2.98735393
26glycosphingolipid catabolic process (GO:0046479)2.98322272
27positive regulation of natural killer cell differentiation (GO:0032825)2.94744515
28substrate-dependent cell migration (GO:0006929)2.94106790
29regulation of membrane protein ectodomain proteolysis (GO:0051043)2.93296658
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.92470193
31positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.86985732
32cell adhesion mediated by integrin (GO:0033627)2.86681632
33lymphangiogenesis (GO:0001946)2.85432882
34regulation of endothelial cell differentiation (GO:0045601)2.83952036
35negative regulation of nitric oxide biosynthetic process (GO:0045019)2.83379961
36macrophage activation involved in immune response (GO:0002281)2.82104484
37NIK/NF-kappaB signaling (GO:0038061)2.81315542
38adhesion of symbiont to host (GO:0044406)2.79641646
39response to host immune response (GO:0052572)2.79506716
40response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.79506716
41cardiac myofibril assembly (GO:0055003)2.79202981
42regulation of interleukin-12 biosynthetic process (GO:0045075)2.78467713
43blood vessel maturation (GO:0001955)2.77512108
44growth hormone receptor signaling pathway (GO:0060396)2.76653497
45regulation of cholesterol storage (GO:0010885)2.74511178
46axon extension involved in axon guidance (GO:0048846)2.74228365
47neuron projection extension involved in neuron projection guidance (GO:1902284)2.74228365
48positive regulation of chemokine biosynthetic process (GO:0045080)2.74007818
49regulation of fever generation (GO:0031620)2.73571560
50myofibril assembly (GO:0030239)2.70737147
51regulation of interferon-beta biosynthetic process (GO:0045357)2.69186174
52positive regulation of heat generation (GO:0031652)2.67444691
53stress fiber assembly (GO:0043149)2.67250085
54regulation of macrophage chemotaxis (GO:0010758)2.67179042
55oligosaccharide catabolic process (GO:0009313)2.65649368
56regulation of podosome assembly (GO:0071801)2.64563148
57regulation of vitamin metabolic process (GO:0030656)2.64107601
58chemical homeostasis within a tissue (GO:0048875)2.63604608
59regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.63568231
60glycolipid catabolic process (GO:0019377)2.62423089
61regulation of T-helper 1 cell differentiation (GO:0045625)2.60975119
62neutrophil activation involved in immune response (GO:0002283)2.60730607
63basement membrane organization (GO:0071711)2.60330295
64positive regulation of macrophage cytokine production (GO:0060907)2.58430481
65positive regulation of interferon-alpha production (GO:0032727)2.58343264
66interferon-gamma-mediated signaling pathway (GO:0060333)2.58326449
67response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.56975834
68response to host (GO:0075136)2.56975834
69response to host defenses (GO:0052200)2.56975834
70neutrophil activation (GO:0042119)2.54551554
71positive regulation of cellular amide metabolic process (GO:0034250)2.54225011
72positive regulation of type 2 immune response (GO:0002830)2.53643027
73positive regulation of antigen processing and presentation (GO:0002579)2.51099302
74wound healing, spreading of epidermal cells (GO:0035313)2.50537346
75regulation of T-helper 2 cell differentiation (GO:0045628)2.50483725
76positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.49842067
77I-kappaB phosphorylation (GO:0007252)2.48954304
78regulation of interferon-alpha production (GO:0032647)2.48223933
79positive regulation of vasculogenesis (GO:2001214)2.47997382
80response to peptidoglycan (GO:0032494)2.47824171
81negative regulation of lipid storage (GO:0010888)2.46204037
82endothelium development (GO:0003158)2.45914296
83glomerular filtration (GO:0003094)2.44605342
84regulation of macrophage cytokine production (GO:0010935)2.44497678
85positive regulation of gamma-delta T cell activation (GO:0046645)2.43630318
86regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.42234737
87keratan sulfate catabolic process (GO:0042340)2.41229212
88response to laminar fluid shear stress (GO:0034616)2.40763695
89granulocyte activation (GO:0036230)2.40312804
90immunoglobulin mediated immune response (GO:0016064)2.39689642
91regulation of vasculogenesis (GO:2001212)2.39303678
92ganglion development (GO:0061548)2.38635802
93myeloid dendritic cell differentiation (GO:0043011)2.38085112
94negative regulation of erythrocyte differentiation (GO:0045647)2.36855368
95cellular response to growth hormone stimulus (GO:0071378)2.36637933
96microglial cell activation (GO:0001774)2.35505642
97venous blood vessel morphogenesis (GO:0048845)2.34543249
98positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.34321782
99positive regulation of receptor recycling (GO:0001921)2.34152564
100regulation of integrin activation (GO:0033623)2.33894029
101regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.32463630
102regulation of chemokine biosynthetic process (GO:0045073)2.32356637
103negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.30736128
104positive regulation of p38MAPK cascade (GO:1900745)2.30658814
105response to thyroid hormone (GO:0097066)2.30164993
106low-density lipoprotein particle clearance (GO:0034383)2.29883187
107type I interferon signaling pathway (GO:0060337)2.29877154
108cellular response to type I interferon (GO:0071357)2.29877154
109patterning of blood vessels (GO:0001569)2.29472494
110apoptotic cell clearance (GO:0043277)2.28467330
111negative regulation of cytokine production involved in immune response (GO:0002719)2.28070886
112cellular response to lipopolysaccharide (GO:0071222)2.27854228
113response to type I interferon (GO:0034340)2.27586448
114negative regulation of cell killing (GO:0031342)2.26409320
115negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.26409320
116lipopolysaccharide-mediated signaling pathway (GO:0031663)2.25636756
117vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.25493817
118cellular extravasation (GO:0045123)2.25176532
119detection of other organism (GO:0098543)2.24353586
120amino sugar catabolic process (GO:0046348)2.23215409
121regulation of cellular extravasation (GO:0002691)2.22921915
122ceramide catabolic process (GO:0046514)2.22777310
123establishment of endothelial barrier (GO:0061028)2.22198297
124detection of external biotic stimulus (GO:0098581)2.21792693
125detection of molecule of bacterial origin (GO:0032490)2.21495008
126cellular response to molecule of bacterial origin (GO:0071219)2.21490446
127positive regulation of cholesterol efflux (GO:0010875)2.21339662
128endothelial cell morphogenesis (GO:0001886)2.21047052
129morphogenesis of an endothelium (GO:0003159)2.20468942
130endothelial tube morphogenesis (GO:0061154)2.20468942
131regulation of T cell tolerance induction (GO:0002664)2.20043083
132macrophage activation (GO:0042116)2.19888448
133myeloid dendritic cell activation (GO:0001773)2.19865890
134renal filtration (GO:0097205)2.19270564
135coronary vasculature morphogenesis (GO:0060977)2.19203290
136peptide catabolic process (GO:0043171)2.19187039
137adenosine receptor signaling pathway (GO:0001973)2.19089913
138mannose metabolic process (GO:0006013)2.18966483
139regulation of type 2 immune response (GO:0002828)2.18807096
140regulation of antigen processing and presentation (GO:0002577)2.18327332
141regulation of cardioblast differentiation (GO:0051890)2.17356073
142Notch signaling involved in heart development (GO:0061314)2.17111142
143regulation of nitric oxide biosynthetic process (GO:0045428)2.16571034
144positive regulation of endothelial cell differentiation (GO:0045603)2.16305194
145angiogenesis involved in wound healing (GO:0060055)2.15586108
146pinocytosis (GO:0006907)2.14848760
147monocyte chemotaxis (GO:0002548)2.14214843
148sarcomere organization (GO:0045214)2.14171238
149atrial septum morphogenesis (GO:0060413)2.14038741
150positive regulation of interleukin-12 production (GO:0032735)2.13561145
151T-helper 1 type immune response (GO:0042088)2.13167835
152positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.12447515
153superoxide anion generation (GO:0042554)2.12309548
154negative regulation of granulocyte differentiation (GO:0030853)2.11804614
155dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.11642809
156platelet-derived growth factor receptor signaling pathway (GO:0048008)2.10478968
157response to fluid shear stress (GO:0034405)2.10073671
158atrioventricular valve morphogenesis (GO:0003181)2.10046643
159regulation of relaxation of muscle (GO:1901077)2.09978342

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.25259835
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.97525219
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.36464833
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.13179804
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.94347220
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.73050827
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.54718706
8GATA2_21666600_ChIP-Seq_HMVEC_Human2.43411019
9* IRF8_27001747_Chip-Seq_BMDM_Mouse2.29616152
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28906907
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.26164049
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23803734
13* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.23366350
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.12720631
15EP300_21415370_ChIP-Seq_HL-1_Mouse1.98262359
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.98149119
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.94836755
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.94821794
19VDR_24787735_ChIP-Seq_THP-1_Human1.86876486
20RUNX_20019798_ChIP-Seq_JUKART_Human1.84281159
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83988931
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.79957288
23* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76105240
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.73633584
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.68876311
26CJUN_26792858_Chip-Seq_BT549_Human1.56097532
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55672135
28CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.52070278
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49212178
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47664100
31PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46140191
32* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44489998
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42167769
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40836160
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40434039
36* TBX20_22080862_ChIP-Seq_HEART_Mouse1.39824578
37* TBX20_22328084_ChIP-Seq_HEART_Mouse1.39824578
38* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38349305
39SPI1_23127762_ChIP-Seq_K562_Human1.37258719
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36343564
41* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27685102
42NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27171607
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26966734
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.25961875
45AHR_22903824_ChIP-Seq_MCF-7_Human1.25260790
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24344065
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22444112
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21882525
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20414347
50NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20414347
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.19284607
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.18152001
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18126723
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17999620
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.17586740
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16597261
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.16326881
58GATA1_22025678_ChIP-Seq_K562_Human1.15237508
59ESR1_20079471_ChIP-ChIP_T-47D_Human1.14446444
60TCF7_22412390_ChIP-Seq_EML_Mouse1.13614528
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12619049
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12122337
63SCL_19346495_ChIP-Seq_HPC-7_Human1.12119258
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11366330
65TP53_16413492_ChIP-PET_HCT116_Human1.11321326
66KDM2B_26808549_Chip-Seq_K562_Human1.10780320
67CLOCK_20551151_ChIP-Seq_293T_Human1.10414210
68LXR_22292898_ChIP-Seq_THP-1_Human1.10017774
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08355956
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08317942
71VDR_21846776_ChIP-Seq_THP-1_Human1.07166282
72KDM2B_26808549_Chip-Seq_DND41_Human1.07032622
73SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06551430
74SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06551430
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06313246
76BRD4_25478319_ChIP-Seq_HGPS_Human1.05568096
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05282752
78SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04458599
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02150877
80TP53_18474530_ChIP-ChIP_U2OS_Human1.01434943
81JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00589532
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00553839
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99756617
84ARNT_22903824_ChIP-Seq_MCF-7_Human0.99407875
85FOXO3_23340844_ChIP-Seq_DLD1_Human0.99378876
86FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99333607
87SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98935345
88ELK3_25401928_ChIP-Seq_HUVEC_Human0.98776601
89JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98627213
90SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98528372
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97107781
92STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96870592
93* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96690562
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95639153
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95587259
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95337189
97SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95201697
98SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94270945
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.94242775
100SOX2_20726797_ChIP-Seq_SW620_Human0.93950804
101RUNX1_22412390_ChIP-Seq_EML_Mouse0.91874216
102FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91738220
103SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91598987
104E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91514613
105PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91378519
106RXR_22108803_ChIP-Seq_LS180_Human0.90165507
107GATA1_19941826_ChIP-Seq_K562_Human0.89967221
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89966521
109* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89890423
110* PU_27001747_Chip-Seq_BMDM_Mouse0.89557471
111NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89033907
112LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88660747
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88588681
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88352263
115UBF1/2_26484160_Chip-Seq_HMECs_Human0.88114925
116LXR_22158963_ChIP-Seq_LIVER_Mouse0.87143204
117DROSHA_22980978_ChIP-Seq_HELA_Human0.86990317
118EZH2_18974828_ChIP-Seq_MESCs_Mouse0.86831787
119RNF2_18974828_ChIP-Seq_MESCs_Mouse0.86831787
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86540839
121WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86496193
122HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86391852
123EED_16625203_ChIP-ChIP_MESCs_Mouse0.86078965
124TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85737883
125VDR_24763502_ChIP-Seq_THP-1_Human0.85155681
126TCF4_18268006_ChIP-ChIP_LS174T_Human0.85049527
127P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84378638
128PIAS1_25552417_ChIP-Seq_VCAP_Human0.84018370
129MTF2_20144788_ChIP-Seq_MESCs_Mouse0.83750018
130MAF_26560356_Chip-Seq_TH1_Human0.82199897

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004510_myositis3.48762995
2MP0001879_abnormal_lymphatic_vessel3.41775556
3MP0010368_abnormal_lymphatic_system3.39840855
4MP0004084_abnormal_cardiac_muscle2.72994611
5MP0003828_pulmonary_edema2.66101825
6MP0003724_increased_susceptibility_to2.64371863
7MP0004272_abnormal_basement_membrane2.54929299
8MP0008438_abnormal_cutaneous_collagen2.46509408
9MP0009840_abnormal_foam_cell2.36576836
10MP0005167_abnormal_blood-brain_barrier2.29930896
11MP0001958_emphysema2.28105383
12MP0001835_abnormal_antigen_presentation2.23448177
13MP0000767_abnormal_smooth_muscle2.17207544
14MP0003279_aneurysm2.15797224
15MP0009278_abnormal_bone_marrow2.10871139
16MP0003303_peritoneal_inflammation2.05894387
17MP0003091_abnormal_cell_migration1.95662431
18MP0003075_altered_response_to1.91068733
19MP0000569_abnormal_digit_pigmentation1.87119796
20MP0002148_abnormal_hypersensitivity_rea1.86242152
21MP0008775_abnormal_heart_ventricle1.85494516
22MP0003172_abnormal_lysosome_physiology1.84832350
23MP0002138_abnormal_hepatobiliary_system1.81491558
24MP0003566_abnormal_cell_adhesion1.81092866
25MP0003436_decreased_susceptibility_to1.79447776
26MP0000343_altered_response_to1.77004639
27MP0002419_abnormal_innate_immunity1.75850223
28MP0003300_gastrointestinal_ulcer1.74052008
29MP0008004_abnormal_stomach_pH1.71649529
30MP0005623_abnormal_meninges_morphology1.68933567
31MP0002166_altered_tumor_susceptibility1.67758634
32MP0005387_immune_system_phenotype1.67648337
33MP0001790_abnormal_immune_system1.67648337
34MP0005503_abnormal_tendon_morphology1.66199635
35MP0000604_amyloidosis1.63833171
36MP0003690_abnormal_glial_cell1.62479744
37MP0009785_altered_susceptibility_to1.59840467
38MP0004036_abnormal_muscle_relaxation1.56635093
39MP0005451_abnormal_body_composition1.54929226
40MP0003705_abnormal_hypodermis_morpholog1.52488352
41MP0004782_abnormal_surfactant_physiolog1.50802528
42MP0000685_abnormal_immune_system1.48128630
43MP0002972_abnormal_cardiac_muscle1.45781150
44MP0005000_abnormal_immune_tolerance1.45347673
45MP0002006_tumorigenesis1.42822468
46MP0010630_abnormal_cardiac_muscle1.42678335
47MP0002998_abnormal_bone_remodeling1.42340668
48MP0004215_abnormal_myocardial_fiber1.41633007
49MP0003448_altered_tumor_morphology1.40879287
50MP0001533_abnormal_skeleton_physiology1.39991367
51MP0002452_abnormal_antigen_presenting1.39024761
52MP0006138_congestive_heart_failure1.36713092
53MP0001544_abnormal_cardiovascular_syste1.35061474
54MP0005385_cardiovascular_system_phenoty1.35061474
55MP0003045_fibrosis1.33364481
56MP0005166_decreased_susceptibility_to1.31716812
57MP0005171_absent_coat_pigmentation1.31257524
58MP0005025_abnormal_response_to1.30824445
59MP0003950_abnormal_plasma_membrane1.30285178
60MP0003453_abnormal_keratinocyte_physiol1.29695439
61MP0000249_abnormal_blood_vessel1.26713640
62MP0005023_abnormal_wound_healing1.24988949
63MP0000751_myopathy1.20284106
64MP0002254_reproductive_system_inflammat1.19781020
65MP0004484_altered_response_of1.18930208
66MP0005330_cardiomyopathy1.18391937
67MP0002723_abnormal_immune_serum1.18277134
68MP0005671_abnormal_response_to1.17413662
69MP0005058_abnormal_lysosome_morphology1.17184350
70MP0000733_abnormal_muscle_development1.17041409
71MP0000465_gastrointestinal_hemorrhage1.16908087
72MP0000920_abnormal_myelination1.16853565
73MP0001800_abnormal_humoral_immune1.14357600
74MP0002933_joint_inflammation1.13652378
75MP0004130_abnormal_muscle_cell1.13451182
76MP0004087_abnormal_muscle_fiber1.13074228
77MP0009764_decreased_sensitivity_to1.12611478
78MP0001845_abnormal_inflammatory_respons1.12034208
79MP0001819_abnormal_immune_cell1.11262223
80MP0002295_abnormal_pulmonary_circulatio1.10500034
81MP0001542_abnormal_bone_strength1.10315700
82MP0002128_abnormal_blood_circulation1.09927331
83MP0005595_abnormal_vascular_smooth1.09420664
84MP0002420_abnormal_adaptive_immunity1.08558914
85MP0000858_altered_metastatic_potential1.05262712
86MP0002405_respiratory_system_inflammati1.05106861
87MP0001853_heart_inflammation1.04291815
88MP0006082_CNS_inflammation1.02523950
89MP0005397_hematopoietic_system_phenotyp1.02286111
90MP0001545_abnormal_hematopoietic_system1.02286111
91MP0001614_abnormal_blood_vessel1.01331413
92MP0002925_abnormal_cardiovascular_devel1.00598686
93MP0005164_abnormal_response_to0.99411050
94MP0000749_muscle_degeneration0.99326594
95MP0005165_increased_susceptibility_to0.98941830
96MP0005275_abnormal_skin_tensile0.97710662
97MP0005390_skeleton_phenotype0.97189346
98MP0004808_abnormal_hematopoietic_stem0.96799230
99MP0005620_abnormal_muscle_contractility0.96650779
100MP0002133_abnormal_respiratory_system0.96156016
101MP0005388_respiratory_system_phenotype0.96156016
102MP0001851_eye_inflammation0.95650647
103MP0003329_amyloid_beta_deposits0.95622117
104MP0008469_abnormal_protein_level0.95121740
105MP0005464_abnormal_platelet_physiology0.95083583
106MP0000750_abnormal_muscle_regeneration0.92312940
107MP0002009_preneoplasia0.89605285
108MP0002877_abnormal_melanocyte_morpholog0.89223455
109MP0010352_gastrointestinal_tract_polyps0.88638501
110MP0005076_abnormal_cell_differentiation0.87873959
111MP0003191_abnormal_cellular_cholesterol0.87753449
112MP0006054_spinal_hemorrhage0.86817003
113MP0002896_abnormal_bone_mineralization0.86630167
114MP0004947_skin_inflammation0.86312505
115MP0002332_abnormal_exercise_endurance0.86028403
116MP0005257_abnormal_intraocular_pressure0.85396509
117MP0004883_abnormal_blood_vessel0.84989361
118MP0010155_abnormal_intestine_physiology0.83721616
119MP0003941_abnormal_skin_development0.83570836
120MP0000371_diluted_coat_color0.83532878
121MP0005409_darkened_coat_color0.83118619
122MP0005670_abnormal_white_adipose0.82848890
123MP0003795_abnormal_bone_structure0.81573330
124MP0003634_abnormal_glial_cell0.79934468
125MP0001849_ear_inflammation0.77334746
126MP0001915_intracranial_hemorrhage0.75040294
127MP0005310_abnormal_salivary_gland0.74328616

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.46870989
2Abnormality of liposaccharide metabolism (HP:0010968)5.46870989
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.46870989
4Hematochezia (HP:0002573)4.29384658
5Eczematoid dermatitis (HP:0000976)3.85930413
6Vacuolated lymphocytes (HP:0001922)3.72283387
7Recurrent abscess formation (HP:0002722)3.67644996
8Dysostosis multiplex (HP:0000943)3.63295907
9Broad metatarsal (HP:0001783)3.41855140
10Spontaneous hematomas (HP:0007420)3.39581049
11Cerebral aneurysm (HP:0004944)3.29366572
12Orchitis (HP:0100796)3.21633071
13Polycythemia (HP:0001901)3.07096576
14Loss of speech (HP:0002371)3.06839102
15Recurrent bacterial skin infections (HP:0005406)3.04931112
16Retrobulbar optic neuritis (HP:0100654)3.02187453
17Optic neuritis (HP:0100653)3.02187453
18Sudden death (HP:0001699)2.99235979
19Neurofibrillary tangles (HP:0002185)2.95705803
20Interstitial pulmonary disease (HP:0006530)2.93096839
21Atrial fibrillation (HP:0005110)2.91212265
22Myositis (HP:0100614)2.90674856
23Ventricular tachycardia (HP:0004756)2.89670617
24Abnormality of polysaccharide metabolism (HP:0011012)2.89193515
25Abnormality of glycosaminoglycan metabolism (HP:0004371)2.89193515
26Abnormality of mucopolysaccharide metabolism (HP:0011020)2.89193515
27Urinary glycosaminoglycan excretion (HP:0003541)2.85408110
28Mucopolysacchariduria (HP:0008155)2.85408110
29Aortic aneurysm (HP:0004942)2.83475242
30Nuclear cataract (HP:0100018)2.70151917
31Aortic dissection (HP:0002647)2.66577410
32Primary atrial arrhythmia (HP:0001692)2.66189988
33Abnormality of the vasculature of the conjunctiva (HP:0008054)2.60734471
34Arterial thrombosis (HP:0004420)2.57712155
35Lipoatrophy (HP:0100578)2.56639702
36Disinhibition (HP:0000734)2.56384902
37Supraventricular arrhythmia (HP:0005115)2.51601758
38Muscle fiber splitting (HP:0003555)2.50957247
39Abnormality of macrophages (HP:0004311)2.50086103
40Autoimmune thrombocytopenia (HP:0001973)2.48376661
41Premature rupture of membranes (HP:0001788)2.47338890
42Recurrent gram-negative bacterial infections (HP:0005420)2.46952703
43Pulmonary infiltrates (HP:0002113)2.46525661
44Supraventricular tachycardia (HP:0004755)2.42249960
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.41983984
46Osteolytic defects of the hand bones (HP:0009699)2.41983984
47Hyporeflexia of lower limbs (HP:0002600)2.41188181
48Subaortic stenosis (HP:0001682)2.40071588
49Abnormality of the left ventricular outflow tract (HP:0011103)2.40071588
50Recurrent fungal infections (HP:0002841)2.40048223
51Mediastinal lymphadenopathy (HP:0100721)2.39737412
52Increased cerebral lipofuscin (HP:0011813)2.38332686
53Peritonitis (HP:0002586)2.36299806
54Gingivitis (HP:0000230)2.30741736
55Hypoplasia of the iris (HP:0007676)2.29824403
56Cerebral inclusion bodies (HP:0100314)2.28625841
57Hypoplastic ischia (HP:0003175)2.27920198
58* Pulmonary artery stenosis (HP:0004415)2.27770998
59Myocardial infarction (HP:0001658)2.27401172
60Glomerulonephritis (HP:0000099)2.26955314
61Vertebral compression fractures (HP:0002953)2.26798614
62Elevated erythrocyte sedimentation rate (HP:0003565)2.26357801
63Conjunctival telangiectasia (HP:0000524)2.26251071
64Increased connective tissue (HP:0009025)2.25221867
65Thick nail (HP:0001805)2.23788021
66Arterial tortuosity (HP:0005116)2.23283554
67Mutism (HP:0002300)2.23268115
68Vascular tortuosity (HP:0004948)2.20582013
69Protrusio acetabuli (HP:0003179)2.20063758
70Amyloidosis (HP:0011034)2.16525312
71Shallow orbits (HP:0000586)2.16149127
72Aneurysm (HP:0002617)2.15654230
73Right ventricular cardiomyopathy (HP:0011663)2.14768098
74Hemoptysis (HP:0002105)2.12043991
75Asymmetry of the thorax (HP:0001555)2.11924882
76Asymmetric septal hypertrophy (HP:0001670)2.09677767
77Apathy (HP:0000741)2.09019011
78* Esophageal varix (HP:0002040)2.08203431
79Distal lower limb muscle weakness (HP:0009053)2.07805534
80Prolonged QT interval (HP:0001657)2.06897971
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.03507618
82Tetraparesis (HP:0002273)2.02875307
83Diminished motivation (HP:0000745)1.98157026
84Abnormality of the endocardium (HP:0004306)1.97213648
85Upper motor neuron abnormality (HP:0002127)1.95604624
86Eosinophilia (HP:0001880)1.95566753
87Abnormality of the ischium (HP:0003174)1.95029988
88Complement deficiency (HP:0004431)1.93903192
89Thin bony cortex (HP:0002753)1.93640224
90Recurrent skin infections (HP:0001581)1.90893231
91Absent frontal sinuses (HP:0002688)1.89963196
92* Pulmonary hypertension (HP:0002092)1.89930600
93Leukocytosis (HP:0001974)1.89333265
94Pigmentary retinal degeneration (HP:0001146)1.89157651
95Increased variability in muscle fiber diameter (HP:0003557)1.89046162
96Persistence of primary teeth (HP:0006335)1.88749113
97Subacute progressive viral hepatitis (HP:0006572)1.88272361
98Emphysema (HP:0002097)1.87760388
99Abnormality of the calf musculature (HP:0001430)1.87568610
100Abnormality of the nasal mucosa (HP:0000433)1.87471965
101Recurrent viral infections (HP:0004429)1.85772728
102Mitral valve prolapse (HP:0001634)1.85006348
103Axonal loss (HP:0003447)1.84940059
104Vasculitis (HP:0002633)1.84905096
105Restrictive lung disease (HP:0002091)1.84143419
106Abnormality of the pericardium (HP:0001697)1.83868517
107Increased CSF protein (HP:0002922)1.83231718
108Dilatation of the ascending aorta (HP:0005111)1.82664529
109Cervical subluxation (HP:0003308)1.82604222
110Prostate neoplasm (HP:0100787)1.82061890
111Joint stiffness (HP:0001387)1.81606679
112Ovoid vertebral bodies (HP:0003300)1.81508204
113Syncope (HP:0001279)1.80596580
114Segmental peripheral demyelination/remyelination (HP:0003481)1.79093345
115Fatigue (HP:0012378)1.79073972
116Syringomyelia (HP:0003396)1.78980256
117Spinal cord lesions (HP:0100561)1.78980256
118Hemangiomatosis (HP:0007461)1.77082131
119Visceral angiomatosis (HP:0100761)1.76868967
120Bicuspid aortic valve (HP:0001647)1.76247359
121Abnormality of complement system (HP:0005339)1.75275607
122Atrophic scars (HP:0001075)1.74994860
123Spinal rigidity (HP:0003306)1.74226148
124Periodontitis (HP:0000704)1.73780039
125Keratoconjunctivitis sicca (HP:0001097)1.73500744
126Cellulitis (HP:0100658)1.73188112
127Gastrointestinal stroma tumor (HP:0100723)1.72905826
128EMG: myopathic abnormalities (HP:0003458)1.72593137
129Neuronal loss in central nervous system (HP:0002529)1.72536061
130Wormian bones (HP:0002645)1.72437485
131Spondylolisthesis (HP:0003302)1.72176065
132Abnormality of skeletal muscle fiber size (HP:0012084)1.71960821
133Cerebral hemorrhage (HP:0001342)1.71702691
134Dilated cardiomyopathy (HP:0001644)1.71625459
135Stomach cancer (HP:0012126)1.70528911
136Purpura (HP:0000979)1.69921649
137Basal ganglia calcification (HP:0002135)1.69785220
138Chronic mucocutaneous candidiasis (HP:0002728)1.69309392
139Recurrent cutaneous fungal infections (HP:0011370)1.69309392
140Lymphangioma (HP:0100764)1.69064927
141Hypoplastic left heart (HP:0004383)1.68941081
142Systemic lupus erythematosus (HP:0002725)1.67764369
143Mucosal telangiectasiae (HP:0100579)1.67097849
144Bone pain (HP:0002653)1.67065490
145Chest pain (HP:0100749)1.65699821
146Protuberant abdomen (HP:0001538)1.61463157
147Overgrowth (HP:0001548)1.60858993
148Distal lower limb amyotrophy (HP:0008944)1.60265315

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.42180892
2MAP3K143.24422110
3KDR3.10686719
4TGFBR23.08927000
5PRPF4B2.54156139
6RIPK12.45937556
7TTN2.39923684
8TYK22.16799719
9JAK12.11194317
10TBK12.05541542
11JAK31.95455203
12DMPK1.91698977
13IKBKB1.80123974
14EPHB11.72868222
15TRIB31.65841460
16MOS1.63599272
17IRAK41.63192349
18CHUK1.62640045
19IRAK31.59953424
20IKBKE1.58658732
21STK241.58015005
22MAP3K131.52026120
23CAMK1D1.45940095
24PTK61.43648054
25FGFR31.43567372
26TAOK21.43007607
27FGR1.40856103
28MYLK1.36139436
29PDGFRA1.35366743
30KIT1.34095850
31EPHA31.32692667
32MATK1.32526343
33PKN21.26675886
34BLK1.26134877
35NEK91.22791576
36TRPM71.22788732
37INSRR1.22550839
38RIPK41.22500789
39TXK1.21818602
40CAMK1G1.19261964
41MAP4K11.17339315
42CSK1.09554136
43PDGFRB1.07311921
44OBSCN1.06752988
45PTK2B1.05767492
46PIK3CA1.05310726
47PRKAA21.04558664
48ZAK1.04449682
49NME21.02008499
50BMX0.98781600
51NUAK10.98479827
52PKN10.96820356
53SIK10.96374924
54MAP2K30.96354974
55FGFR40.95205048
56LATS20.94225511
57TGFBR10.92486964
58MAP3K10.88053792
59TYRO30.88052929
60PIM20.86871703
61TEC0.86836772
62MARK30.86031801
63MAP3K110.85965769
64STK30.85797419
65RPS6KA20.82756053
66EPHB20.81291927
67HCK0.79913835
68ZAP700.79675460
69LATS10.78757603
70JAK20.77547549
71ABL20.76579673
72IRAK10.74851676
73PRKD10.74754090
74ICK0.74378421
75LMTK20.73700650
76TAOK10.73560975
77GRK10.73511207
78STK100.71366462
79CSF1R0.70682232
80NLK0.69666334
81BMPR20.68837010
82SYK0.66347420
83MAPK40.66140860
84MARK20.65589428
85ERN10.65423539
86FES0.64119303
87EIF2AK20.63348444
88MAPK120.62847566
89CDK60.60606879
90LYN0.60272355
91KSR20.60012345
92PDPK10.59670040
93LCK0.59622440
94EGFR0.58906125
95WNK10.58366292
96PAK40.58336654
97IRAK20.58222753
98PTK20.57638828
99MAP3K50.55228322
100PIK3CG0.55121285
101MAP3K30.54605673
102RPS6KC10.54411675
103RPS6KL10.54411675
104ROCK20.53962012
105LRRK20.53676744
106MAP3K70.53616882
107ROCK10.52896864
108IGF1R0.52343409
109PRKCH0.52218393
110CLK10.51614174
111PDK20.51252909
112MAPK70.50947938
113ABL10.50155187
114MAP3K60.49935011
115SGK30.49660220
116SGK20.48921831
117PRKCQ0.48904992
118PRKD20.48734468
119RET0.48501057
120PAK20.48445172
121RPS6KA40.48411858
122CAMK40.48290021
123ITK0.47656840
124STK40.47476771
125FER0.47390362
126DDR20.46110295
127GRK70.46022819
128PRKG20.45738300
129PRKCE0.45194079
130PDK10.44978384
131PIM10.43985522
132CAMKK20.42891997
133NTRK10.42760671
134LIMK10.42421688
135TAOK30.41945144
136EEF2K0.41741246
137CDC42BPA0.41430266
138FLT30.41237795
139BTK0.40795724
140INSR0.40641678

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.27266089
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.01014601
3Osteoclast differentiation_Homo sapiens_hsa043801.99589419
4Dilated cardiomyopathy_Homo sapiens_hsa054141.91198061
5Toll-like receptor signaling pathway_Homo sapiens_hsa046201.90579626
6Malaria_Homo sapiens_hsa051441.89278907
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.86963718
8TNF signaling pathway_Homo sapiens_hsa046681.79735425
9Toxoplasmosis_Homo sapiens_hsa051451.79698931
10Viral myocarditis_Homo sapiens_hsa054161.78641827
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.69849034
12ECM-receptor interaction_Homo sapiens_hsa045121.68904928
13Measles_Homo sapiens_hsa051621.58827908
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.56392650
15Focal adhesion_Homo sapiens_hsa045101.55957638
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.50606587
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49322946
18Allograft rejection_Homo sapiens_hsa053301.43948758
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.43499738
20Small cell lung cancer_Homo sapiens_hsa052221.41038912
21Pertussis_Homo sapiens_hsa051331.39331205
22Adherens junction_Homo sapiens_hsa045201.38983998
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35759904
24Graft-versus-host disease_Homo sapiens_hsa053321.33330654
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.32762388
26Staphylococcus aureus infection_Homo sapiens_hsa051501.32569967
27Amoebiasis_Homo sapiens_hsa051461.31951317
28Chemokine signaling pathway_Homo sapiens_hsa040621.27244115
29Tuberculosis_Homo sapiens_hsa051521.27058032
30Prion diseases_Homo sapiens_hsa050201.24996193
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22014645
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20468281
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.20378417
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20171380
35Influenza A_Homo sapiens_hsa051641.19411632
36Platelet activation_Homo sapiens_hsa046111.18793174
37Salmonella infection_Homo sapiens_hsa051321.18711790
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17585881
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17163081
40Rheumatoid arthritis_Homo sapiens_hsa053231.15896434
41B cell receptor signaling pathway_Homo sapiens_hsa046621.15764964
42Apoptosis_Homo sapiens_hsa042101.13216918
43Legionellosis_Homo sapiens_hsa051341.13153599
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13095498
45Chronic myeloid leukemia_Homo sapiens_hsa052201.12274676
46Type I diabetes mellitus_Homo sapiens_hsa049401.12128859
47Hematopoietic cell lineage_Homo sapiens_hsa046401.09346063
48Proteoglycans in cancer_Homo sapiens_hsa052051.06985564
49Lysosome_Homo sapiens_hsa041421.03552676
50African trypanosomiasis_Homo sapiens_hsa051431.03159105
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96722872
52Bladder cancer_Homo sapiens_hsa052190.96109308
53Antigen processing and presentation_Homo sapiens_hsa046120.96001752
54Shigellosis_Homo sapiens_hsa051310.95582736
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93170726
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91799600
57Dorso-ventral axis formation_Homo sapiens_hsa043200.91568293
58HIF-1 signaling pathway_Homo sapiens_hsa040660.91371302
59Autoimmune thyroid disease_Homo sapiens_hsa053200.91055608
60Pancreatic cancer_Homo sapiens_hsa052120.91038041
61Hepatitis B_Homo sapiens_hsa051610.88749520
62Insulin resistance_Homo sapiens_hsa049310.88705752
63Acute myeloid leukemia_Homo sapiens_hsa052210.87710549
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.87161914
65Herpes simplex infection_Homo sapiens_hsa051680.87003252
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.86267191
67Notch signaling pathway_Homo sapiens_hsa043300.86008842
68MicroRNAs in cancer_Homo sapiens_hsa052060.85358116
69Asthma_Homo sapiens_hsa053100.84897542
70Phagosome_Homo sapiens_hsa041450.83727657
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82395193
72Hepatitis C_Homo sapiens_hsa051600.82291365
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80378873
74Prolactin signaling pathway_Homo sapiens_hsa049170.80286541
75Rap1 signaling pathway_Homo sapiens_hsa040150.79464993
76Complement and coagulation cascades_Homo sapiens_hsa046100.77470148
77Other glycan degradation_Homo sapiens_hsa005110.77154427
78T cell receptor signaling pathway_Homo sapiens_hsa046600.76413278
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75636890
80PPAR signaling pathway_Homo sapiens_hsa033200.74469838
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.70233738
82GnRH signaling pathway_Homo sapiens_hsa049120.69226019
83Pathways in cancer_Homo sapiens_hsa052000.69188323
84Renal cell carcinoma_Homo sapiens_hsa052110.69174244
85Type II diabetes mellitus_Homo sapiens_hsa049300.68979468
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68918000
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68873816
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68741653
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68493596
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.66823478
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64808821
92Prostate cancer_Homo sapiens_hsa052150.63098024
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.62806178
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62123063
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61991467
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.61932024
97MAPK signaling pathway_Homo sapiens_hsa040100.60280618
98HTLV-I infection_Homo sapiens_hsa051660.58722138
99FoxO signaling pathway_Homo sapiens_hsa040680.58666256
100Renin secretion_Homo sapiens_hsa049240.58095531
101Ovarian steroidogenesis_Homo sapiens_hsa049130.57945126
102VEGF signaling pathway_Homo sapiens_hsa043700.57562592
103Sphingolipid metabolism_Homo sapiens_hsa006000.56549889
104Estrogen signaling pathway_Homo sapiens_hsa049150.55150304
105Melanoma_Homo sapiens_hsa052180.52791633
106Ras signaling pathway_Homo sapiens_hsa040140.52522083
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52257083
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51972865
109Endocytosis_Homo sapiens_hsa041440.51675795
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49594063
111Vibrio cholerae infection_Homo sapiens_hsa051100.46796279
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45871897
113Glioma_Homo sapiens_hsa052140.40823775

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