ARHGAP32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.04112024
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.89895899
3synaptic vesicle maturation (GO:0016188)5.79948441
4locomotory exploration behavior (GO:0035641)5.67588744
5vocalization behavior (GO:0071625)5.47483807
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.29817930
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.28754882
8synaptic vesicle exocytosis (GO:0016079)5.26557590
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.26493529
10glutamate secretion (GO:0014047)5.20923205
11regulation of glutamate receptor signaling pathway (GO:1900449)4.95030842
12regulation of synaptic vesicle exocytosis (GO:2000300)4.84956701
13protein localization to synapse (GO:0035418)4.66260270
14regulation of long-term neuronal synaptic plasticity (GO:0048169)4.50700290
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.46853573
16regulation of neuronal synaptic plasticity (GO:0048168)4.42089841
17dendritic spine morphogenesis (GO:0060997)4.41204728
18neuronal action potential propagation (GO:0019227)4.37606979
19neuron cell-cell adhesion (GO:0007158)4.29112925
20regulation of synaptic vesicle transport (GO:1902803)4.25460774
21regulation of synapse structural plasticity (GO:0051823)4.22572030
22exploration behavior (GO:0035640)4.22432486
23layer formation in cerebral cortex (GO:0021819)4.20816322
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.18998499
25neurotransmitter secretion (GO:0007269)4.16989020
26neurotransmitter-gated ion channel clustering (GO:0072578)4.14776896
27synaptic transmission, glutamatergic (GO:0035249)4.13256266
28glutamate receptor signaling pathway (GO:0007215)4.03703414
29neuron-neuron synaptic transmission (GO:0007270)3.98977030
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.96763291
31regulation of excitatory postsynaptic membrane potential (GO:0060079)3.91993718
32positive regulation of membrane potential (GO:0045838)3.89765055
33regulation of dendritic spine morphogenesis (GO:0061001)3.85190856
34long-term memory (GO:0007616)3.81782387
35regulation of postsynaptic membrane potential (GO:0060078)3.77898666
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.74873741
37cellular potassium ion homeostasis (GO:0030007)3.66990213
38regulation of synaptic plasticity (GO:0048167)3.65417644
39auditory behavior (GO:0031223)3.65190004
40cytoskeletal anchoring at plasma membrane (GO:0007016)3.60141799
41long-term synaptic potentiation (GO:0060291)3.54591677
42positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.54227372
43neuromuscular process controlling balance (GO:0050885)3.53269373
44gamma-aminobutyric acid transport (GO:0015812)3.51257810
45proline transport (GO:0015824)3.49838531
46positive regulation of neurotransmitter secretion (GO:0001956)3.47442436
47membrane hyperpolarization (GO:0060081)3.44475682
48regulation of synaptic transmission, glutamatergic (GO:0051966)3.43684798
49positive regulation of neurotransmitter transport (GO:0051590)3.42453580
50regulation of neurotransmitter secretion (GO:0046928)3.39403277
51neurotransmitter transport (GO:0006836)3.38879300
52prepulse inhibition (GO:0060134)3.37708719
53response to auditory stimulus (GO:0010996)3.36849074
54G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.36207218
55neuron recognition (GO:0008038)3.35380844
56transmission of nerve impulse (GO:0019226)3.35146482
57positive regulation of synapse maturation (GO:0090129)3.34749032
58response to histamine (GO:0034776)3.31912968
59activation of protein kinase A activity (GO:0034199)3.31637328
60cerebellar Purkinje cell differentiation (GO:0021702)3.29743700
61regulation of dendritic spine development (GO:0060998)3.28860126
62embryonic retina morphogenesis in camera-type eye (GO:0060059)3.26937692
63sodium ion export (GO:0071436)3.24475422
64amino acid import (GO:0043090)3.24314634
65dendritic spine organization (GO:0097061)3.23558389
66L-amino acid import (GO:0043092)3.23092033
67presynaptic membrane assembly (GO:0097105)3.22967448
68axonal fasciculation (GO:0007413)3.20112613
69apical protein localization (GO:0045176)3.19885615
70synaptic vesicle endocytosis (GO:0048488)3.17675881
71negative regulation of dendrite morphogenesis (GO:0050774)3.16884552
72regulation of neurotransmitter transport (GO:0051588)3.15824092
73positive regulation of synaptic transmission, GABAergic (GO:0032230)3.15391605
74desmosome organization (GO:0002934)3.15181940
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15078144
76behavioral response to cocaine (GO:0048148)3.14825371
77gamma-aminobutyric acid signaling pathway (GO:0007214)3.14702090
78postsynaptic membrane organization (GO:0001941)3.13529908
79membrane depolarization (GO:0051899)3.10418300
80regulation of neurotransmitter levels (GO:0001505)3.10012531
81dendrite morphogenesis (GO:0048813)3.10009538
82regulation of voltage-gated calcium channel activity (GO:1901385)3.09573583
83negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.09305405
84negative regulation of synaptic transmission, GABAergic (GO:0032229)3.08966648
85cell communication involved in cardiac conduction (GO:0086065)3.06960743
86neuronal ion channel clustering (GO:0045161)3.06918937
87regulation of vesicle fusion (GO:0031338)3.04770302
88chemosensory behavior (GO:0007635)3.04194316
89learning (GO:0007612)3.03681741
90cellular sodium ion homeostasis (GO:0006883)3.01209336
91behavioral defense response (GO:0002209)3.01206142
92behavioral fear response (GO:0001662)3.01206142
93regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.01105251
94positive regulation of synaptic transmission (GO:0050806)3.01093045
95regulation of ARF protein signal transduction (GO:0032012)2.99119696
96presynaptic membrane organization (GO:0097090)2.98435215
97innervation (GO:0060384)2.98414299
98mechanosensory behavior (GO:0007638)2.97222844
99glycine transport (GO:0015816)2.94974489
100positive regulation of dendritic spine development (GO:0060999)2.94755209
101neuromuscular process (GO:0050905)2.92970665
102long term synaptic depression (GO:0060292)2.91945740
103central nervous system myelination (GO:0022010)2.91609287
104axon ensheathment in central nervous system (GO:0032291)2.91609287
105synapse assembly (GO:0007416)2.91507799
106cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.91486466
107regulation of synaptic transmission (GO:0050804)2.89733413
108membrane depolarization during action potential (GO:0086010)2.88985652
109striatum development (GO:0021756)2.88870278
110cerebellar granule cell differentiation (GO:0021707)2.87610542
111potassium ion homeostasis (GO:0055075)2.87473769
112fear response (GO:0042596)2.85194068
113positive regulation of dendritic spine morphogenesis (GO:0061003)2.73702790
114negative regulation of dendrite development (GO:2000171)2.71538056
115asymmetric protein localization (GO:0008105)2.65791280
116cell communication by electrical coupling (GO:0010644)2.60157705
117potassium ion import (GO:0010107)2.57024055
118cardiac conduction (GO:0061337)2.55181249
119regulation of heart rate by cardiac conduction (GO:0086091)2.52358317
120myelin maintenance (GO:0043217)2.52320323
121regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.49024447
122long-chain fatty acid biosynthetic process (GO:0042759)2.48864682
123cochlea development (GO:0090102)2.45346189
124startle response (GO:0001964)2.40198573
125regulation of synapse maturation (GO:0090128)2.37137352
126multicellular organismal signaling (GO:0035637)2.35859395
127cell differentiation in hindbrain (GO:0021533)2.34523555
128sodium ion homeostasis (GO:0055078)2.34202045
129establishment of skin barrier (GO:0061436)2.34124493
130regulation of calcium ion-dependent exocytosis (GO:0017158)2.30990261
131regulation of dendrite morphogenesis (GO:0048814)2.30138066
132regulation of clathrin-mediated endocytosis (GO:2000369)2.30086717
133negative regulation of neurotransmitter secretion (GO:0046929)2.27812255
134central nervous system projection neuron axonogenesis (GO:0021952)2.27554813

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.60271863
2GBX2_23144817_ChIP-Seq_PC3_Human3.46397982
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02327602
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97448265
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94574007
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.70710506
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67251131
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67251131
9DROSHA_22980978_ChIP-Seq_HELA_Human2.64182592
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54971509
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49976399
12REST_21632747_ChIP-Seq_MESCs_Mouse2.49383665
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.43461161
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41592352
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38692174
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37547627
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36219201
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.19051779
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.17854596
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17212194
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16200430
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.12240700
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06543647
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01033224
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.96630690
26AR_21572438_ChIP-Seq_LNCaP_Human1.91491118
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91415925
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.89274944
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80628824
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77531943
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.75178579
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70685653
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69609848
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.66588177
35SMAD4_21799915_ChIP-Seq_A2780_Human1.62037402
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.60399880
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59314407
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55279750
39TAF15_26573619_Chip-Seq_HEK293_Human1.55269526
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44570927
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.41895840
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38876555
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.37084024
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37081779
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35354638
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.33938931
47WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31161159
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.30658266
49P300_19829295_ChIP-Seq_ESCs_Human1.30322554
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29991212
51RING1B_27294783_Chip-Seq_ESCs_Mouse1.29880196
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.28900447
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28683209
54CDX2_20551321_ChIP-Seq_CACO-2_Human1.27964447
55STAT3_23295773_ChIP-Seq_U87_Human1.27569627
56AR_19668381_ChIP-Seq_PC3_Human1.25218504
57CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25019289
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24782931
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23792956
60TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22305988
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.20311602
62RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19939106
63P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19742970
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.19502954
65AHR_22903824_ChIP-Seq_MCF-7_Human1.19437303
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18170385
67TP53_16413492_ChIP-PET_HCT116_Human1.17891552
68* PIAS1_25552417_ChIP-Seq_VCAP_Human1.17746121
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.17735582
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17404099
71AR_25329375_ChIP-Seq_VCAP_Human1.17204022
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16181670
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16146248
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15264197
75ZNF274_21170338_ChIP-Seq_K562_Hela1.14019113
76* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13723132
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13430399
78YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13193081
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12539634
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12269215
81TCF4_23295773_ChIP-Seq_U87_Human1.11067160
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10942377
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10555605
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10082711
85* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09013436
86KDM2B_26808549_Chip-Seq_K562_Human1.08771661
87FOXA2_19822575_ChIP-Seq_HepG2_Human1.08250156
88* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07421977
89SMAD3_21741376_ChIP-Seq_HESCs_Human1.05791743
90SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05337759
91DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04556075
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03706343
93LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03586614
94EP300_21415370_ChIP-Seq_HL-1_Mouse1.03320731
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02712597
96NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01444845
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01431039
98RXR_22108803_ChIP-Seq_LS180_Human1.01269528
99RNF2_27304074_Chip-Seq_NSC_Mouse1.00450646
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00368731
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99893544
102* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99758488
103ISL1_27105846_Chip-Seq_CPCs_Mouse0.99488199
104SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99237009
105FUS_26573619_Chip-Seq_HEK293_Human0.99041017
106FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98752908
107ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98009173
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97309963
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97309963
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96617395
111RUNX2_22187159_ChIP-Seq_PCA_Human0.96599455
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.95994845
113EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95548753
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.95405719
115ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94903627
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94710664
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94349532
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94160327
119PRDM14_20953172_ChIP-Seq_ESCs_Human0.92507608
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90767302
121POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90321586
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89025278
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88663862

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.66120876
2MP0003880_abnormal_central_pattern4.64383731
3MP0003635_abnormal_synaptic_transmissio4.17592788
4MP0004270_analgesia3.96439902
5MP0002822_catalepsy3.65731303
6MP0009745_abnormal_behavioral_response3.42887525
7MP0002063_abnormal_learning/memory/cond3.39301212
8MP0002064_seizures3.13885625
9MP0009046_muscle_twitch3.08213449
10MP0000566_synostosis2.93387350
11MP0001486_abnormal_startle_reflex2.85302850
12MP0002572_abnormal_emotion/affect_behav2.82382165
13MP0001968_abnormal_touch/_nociception2.79792246
14MP0005423_abnormal_somatic_nervous2.71625998
15MP0002272_abnormal_nervous_system2.54628830
16MP0002734_abnormal_mechanical_nocicepti2.50569155
17MP0009780_abnormal_chondrocyte_physiolo2.22838718
18MP0001501_abnormal_sleep_pattern2.07056461
19MP0000579_abnormal_nail_morphology1.92952035
20MP0001440_abnormal_grooming_behavior1.92837780
21MP0008569_lethality_at_weaning1.84085917
22MP0002736_abnormal_nociception_after1.84080374
23MP0002067_abnormal_sensory_capabilities1.81284573
24MP0000778_abnormal_nervous_system1.80669289
25MP0010678_abnormal_skin_adnexa1.80039334
26MP0005646_abnormal_pituitary_gland1.77813729
27MP0002733_abnormal_thermal_nociception1.77792893
28MP0001970_abnormal_pain_threshold1.75959269
29MP0002557_abnormal_social/conspecific_i1.75182395
30MP0001346_abnormal_lacrimal_gland1.75147562
31MP0004924_abnormal_behavior1.74928604
32MP0005386_behavior/neurological_phenoty1.74928604
33MP0003879_abnormal_hair_cell1.72988090
34MP0004811_abnormal_neuron_physiology1.69501294
35MP0000383_abnormal_hair_follicle1.68865009
36MP0004885_abnormal_endolymph1.67392501
37MP0002909_abnormal_adrenal_gland1.64450041
38MP0004858_abnormal_nervous_system1.62386798
39MP0002796_impaired_skin_barrier1.62353157
40MP0002735_abnormal_chemical_nociception1.58775658
41MP0002184_abnormal_innervation1.58427716
42MP0001984_abnormal_olfaction1.55419546
43MP0003329_amyloid_beta_deposits1.54465677
44MP0000955_abnormal_spinal_cord1.43493211
45* MP0002882_abnormal_neuron_morphology1.40004303
46MP0004264_abnormal_extraembryonic_tissu1.38209474
47MP0003633_abnormal_nervous_system1.38160232
48MP0002066_abnormal_motor_capabilities/c1.35679423
49MP0000537_abnormal_urethra_morphology1.34964167
50MP0003787_abnormal_imprinting1.33629732
51MP0001529_abnormal_vocalization1.32505360
52MP0005248_abnormal_Harderian_gland1.30437890
53MP0005551_abnormal_eye_electrophysiolog1.24021779
54MP0001188_hyperpigmentation1.20821289
55MP0000569_abnormal_digit_pigmentation1.15926515
56MP0003631_nervous_system_phenotype1.15781773
57MP0002098_abnormal_vibrissa_morphology1.14943719
58MP0002152_abnormal_brain_morphology1.13761844
59MP0003283_abnormal_digestive_organ1.13664634
60MP0001502_abnormal_circadian_rhythm1.13055896
61MP0005409_darkened_coat_color1.12331314
62MP0001177_atelectasis1.08826293
63MP0008872_abnormal_physiological_respon1.07261467
64MP0001905_abnormal_dopamine_level1.00645150
65MP0005645_abnormal_hypothalamus_physiol0.99594384
66MP0003123_paternal_imprinting0.99485988
67MP0004742_abnormal_vestibular_system0.99056683
68MP0010234_abnormal_vibrissa_follicle0.98822150
69MP0002249_abnormal_larynx_morphology0.95843714
70MP0002229_neurodegeneration0.95254301
71MP0003690_abnormal_glial_cell0.94737790
72MP0001485_abnormal_pinna_reflex0.93616059
73MP0008874_decreased_physiological_sensi0.93268965
74MP0000751_myopathy0.92773834
75MP0008961_abnormal_basal_metabolism0.92708186
76MP0002069_abnormal_eating/drinking_beha0.92158187
77MP0000534_abnormal_ureter_morphology0.91496854
78MP0000427_abnormal_hair_cycle0.90640413
79MP0001765_abnormal_ion_homeostasis0.90593004
80MP0006276_abnormal_autonomic_nervous0.90251545
81MP0005499_abnormal_olfactory_system0.88467053
82MP0005394_taste/olfaction_phenotype0.88467053
83MP0004085_abnormal_heartbeat0.87815228
84MP0000631_abnormal_neuroendocrine_gland0.87774779
85MP0010352_gastrointestinal_tract_polyps0.86693313
86MP0004142_abnormal_muscle_tone0.85879988
87MP0002234_abnormal_pharynx_morphology0.85369807
88MP0001666_abnormal_nutrient_absorption0.85352610
89MP0002090_abnormal_vision0.84702581
90MP0001963_abnormal_hearing_physiology0.84563617
91MP0004145_abnormal_muscle_electrophysio0.83593735
92MP0010386_abnormal_urinary_bladder0.83260813
93MP0000462_abnormal_digestive_system0.82496156
94MP0003075_altered_response_to0.82132104
95MP0003705_abnormal_hypodermis_morpholog0.82123894
96MP0000920_abnormal_myelination0.82103123
97MP0003632_abnormal_nervous_system0.81416564
98MP0003122_maternal_imprinting0.80236238
99MP0008875_abnormal_xenobiotic_pharmacok0.80214737
100MP0003634_abnormal_glial_cell0.77840711
101MP0002752_abnormal_somatic_nervous0.75590588
102MP0003890_abnormal_embryonic-extraembry0.75109625
103MP0005623_abnormal_meninges_morphology0.72741753
104MP0003183_abnormal_peptide_metabolism0.72504355
105MP0004043_abnormal_pH_regulation0.70754339
106MP0005167_abnormal_blood-brain_barrier0.70619287
107MP0000377_abnormal_hair_follicle0.70501852
108MP0001664_abnormal_digestion0.69753513
109MP0005076_abnormal_cell_differentiation0.69250942
110MP0005535_abnormal_body_temperature0.68834972
111MP0000013_abnormal_adipose_tissue0.68421469
112MP0002653_abnormal_ependyma_morphology0.68272803
113MP0000026_abnormal_inner_ear0.66066189
114MP0005187_abnormal_penis_morphology0.65954398
115MP0004215_abnormal_myocardial_fiber0.65688494
116MP0000647_abnormal_sebaceous_gland0.65638786
117MP0003868_abnormal_feces_composition0.65344661
118MP0004233_abnormal_muscle_weight0.64897687
119* MP0003861_abnormal_nervous_system0.64444397
120MP0003137_abnormal_impulse_conducting0.62518882
121MP0004484_altered_response_of0.62124393
122MP0001943_abnormal_respiration0.61784421
123MP0001299_abnormal_eye_distance/0.55668796
124MP0010769_abnormal_survival0.54137960
125MP0002082_postnatal_lethality0.52634264
126MP0010770_preweaning_lethality0.52634264
127MP0006072_abnormal_retinal_apoptosis0.51397315
128MP0010768_mortality/aging0.50730625
129MP0005253_abnormal_eye_physiology0.50516075

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.65476300
2Myokymia (HP:0002411)6.81876558
3Focal seizures (HP:0007359)5.80868624
4Epileptic encephalopathy (HP:0200134)5.04674903
5Visual hallucinations (HP:0002367)4.42518598
6Febrile seizures (HP:0002373)4.07272023
7Progressive cerebellar ataxia (HP:0002073)4.01229252
8Atonic seizures (HP:0010819)3.98414713
9Broad-based gait (HP:0002136)3.86867425
10Action tremor (HP:0002345)3.86334339
11Absence seizures (HP:0002121)3.80487967
12Poor eye contact (HP:0000817)3.67436112
13Generalized tonic-clonic seizures (HP:0002069)3.66935943
14Gaze-evoked nystagmus (HP:0000640)3.66128824
15Dialeptic seizures (HP:0011146)3.50749916
16Hyperventilation (HP:0002883)3.42173080
17Impaired vibration sensation in the lower limbs (HP:0002166)3.37738291
18Dysdiadochokinesis (HP:0002075)3.34070820
19Ankle clonus (HP:0011448)3.33710672
20Urinary bladder sphincter dysfunction (HP:0002839)3.31629709
21Impaired social interactions (HP:0000735)3.30734349
22Abnormal social behavior (HP:0012433)3.30734349
23Dysmetria (HP:0001310)3.05537094
24Depression (HP:0000716)3.00489680
25Amblyopia (HP:0000646)2.93471925
26Genetic anticipation (HP:0003743)2.92006675
27Postural instability (HP:0002172)2.88505032
28Truncal ataxia (HP:0002078)2.88217253
29Scanning speech (HP:0002168)2.85643204
30Stereotypic behavior (HP:0000733)2.84022305
31Anxiety (HP:0000739)2.80122304
32Supranuclear gaze palsy (HP:0000605)2.79765885
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.78610683
34Impaired smooth pursuit (HP:0007772)2.74254370
35Papilledema (HP:0001085)2.73722724
36Dysmetric saccades (HP:0000641)2.72263551
37Torticollis (HP:0000473)2.70972537
38Excessive salivation (HP:0003781)2.69911953
39Drooling (HP:0002307)2.69911953
40Urinary urgency (HP:0000012)2.65909494
41Intention tremor (HP:0002080)2.62433385
42Abnormal eating behavior (HP:0100738)2.56133305
43Spastic gait (HP:0002064)2.52429917
44Insidious onset (HP:0003587)2.49115740
45Termporal pattern (HP:0011008)2.49115740
46Bronchomalacia (HP:0002780)2.48961430
47Annular pancreas (HP:0001734)2.46835255
48Megalencephaly (HP:0001355)2.44799549
49Focal dystonia (HP:0004373)2.44693605
50Epileptiform EEG discharges (HP:0011182)2.44133285
51Abnormality of the lower motor neuron (HP:0002366)2.44128062
52Hemiparesis (HP:0001269)2.43928667
53Ankyloglossia (HP:0010296)2.43361639
54Impaired vibratory sensation (HP:0002495)2.41245398
55Abnormality of ocular smooth pursuit (HP:0000617)2.40131932
56Absent speech (HP:0001344)2.37164114
57EEG with generalized epileptiform discharges (HP:0011198)2.33583143
58Mutism (HP:0002300)2.30180683
59Right ventricular cardiomyopathy (HP:0011663)2.28641625
60Hypoplastic labia majora (HP:0000059)2.27359287
61Bradykinesia (HP:0002067)2.25133424
62Hemiplegia (HP:0002301)2.20953380
63Abnormality of the corticospinal tract (HP:0002492)2.20947995
64Hypsarrhythmia (HP:0002521)2.19162978
65Abnormal ciliary motility (HP:0012262)2.18658002
66Alacrima (HP:0000522)2.18321181
67Craniofacial dystonia (HP:0012179)2.17353643
68Ventricular fibrillation (HP:0001663)2.13954506
69Status epilepticus (HP:0002133)2.13088459
70Rhinitis (HP:0012384)2.12110240
71Sleep apnea (HP:0010535)2.11973298
72Papillary thyroid carcinoma (HP:0002895)2.11830987
73Pointed chin (HP:0000307)2.11785908
74Resting tremor (HP:0002322)2.10067084
75Lower limb muscle weakness (HP:0007340)2.09728149
76Abnormal respiratory motile cilium physiology (HP:0012261)2.07878706
77Cerebral inclusion bodies (HP:0100314)2.07135155
78Neurofibrillary tangles (HP:0002185)2.05925551
79Absent/shortened dynein arms (HP:0200106)2.02840025
80Dynein arm defect of respiratory motile cilia (HP:0012255)2.02840025
81Hepatoblastoma (HP:0002884)2.01951963
82Obstructive sleep apnea (HP:0002870)2.01696673
83Abnormality of the labia majora (HP:0012881)2.01379320
84Aplasia involving bones of the upper limbs (HP:0009823)1.98761599
85Aplasia of the phalanges of the hand (HP:0009802)1.98761599
86Aplasia involving bones of the extremities (HP:0009825)1.98761599
87Fetal akinesia sequence (HP:0001989)1.97757708
88Inability to walk (HP:0002540)1.97172908
89Generalized myoclonic seizures (HP:0002123)1.97093069
90Lower limb amyotrophy (HP:0007210)1.96879063
91Incomplete penetrance (HP:0003829)1.96838191
92Lip pit (HP:0100267)1.96765415
93Blue irides (HP:0000635)1.94032127
94Prolonged QT interval (HP:0001657)1.91868721
95Abnormality of nail color (HP:0100643)1.90252557
96Abnormality of binocular vision (HP:0011514)1.89971890
97Diplopia (HP:0000651)1.89971890
98Hyperkalemia (HP:0002153)1.89934796
99Hyperactive renin-angiotensin system (HP:0000841)1.89777466
100Germ cell neoplasia (HP:0100728)1.89584366
101Abnormal respiratory motile cilium morphology (HP:0005938)1.85725424
102Abnormal respiratory epithelium morphology (HP:0012253)1.85725424
103Tracheomalacia (HP:0002779)1.84869916
104Progressive inability to walk (HP:0002505)1.84737068
105Gait ataxia (HP:0002066)1.84007844
106Laryngomalacia (HP:0001601)1.83756810
107Decreased lacrimation (HP:0000633)1.83584604
108Clonus (HP:0002169)1.82986072
109Shallow orbits (HP:0000586)1.81940846
110Akinesia (HP:0002304)1.80937773
111Abnormal EKG (HP:0003115)1.80895208
112Chronic bronchitis (HP:0004469)1.80704459
113Protruding tongue (HP:0010808)1.78609814
114Abnormality of salivation (HP:0100755)1.76735452
115Abnormality of the proximal phalanges of the hand (HP:0009834)1.75890962
116Insomnia (HP:0100785)1.74679858
117Abnormality of the periventricular white matter (HP:0002518)1.72478724
118Inappropriate behavior (HP:0000719)1.71844041
119Bundle branch block (HP:0011710)1.71605492
120Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.71517851
121Degeneration of the lateral corticospinal tracts (HP:0002314)1.71517851
122Abnormality of saccadic eye movements (HP:0000570)1.71210709
123Intellectual disability, profound (HP:0002187)1.70153538
124Macroorchidism (HP:0000053)1.70121889
125Vertebral arch anomaly (HP:0008438)1.69716067
126Abnormality of permanent molar morphology (HP:0011071)1.69531283
127Abnormality of the dental root (HP:0006486)1.69531283
128Taurodontia (HP:0000679)1.69531283
129Autism (HP:0000717)1.69251225
130Lower limb asymmetry (HP:0100559)1.67332716
131Abnormality of oral frenula (HP:0000190)1.66757127
132Deeply set eye (HP:0000490)1.65959743
133Syncope (HP:0001279)1.65531033
134Cutaneous finger syndactyly (HP:0010554)1.63358879
135Thickened helices (HP:0000391)1.60804406
136Curly hair (HP:0002212)1.56837859
137Labial hypoplasia (HP:0000066)1.54590131
138Bell-shaped thorax (HP:0001591)1.52793985
139Tubulointerstitial nephritis (HP:0001970)1.51802909
140Abnormality of molar (HP:0011077)1.50670969
141Abnormality of molar morphology (HP:0011070)1.50670969
142Bifid scrotum (HP:0000048)1.49518592
143Hyperaldosteronism (HP:0000859)1.48374809
144Morphological abnormality of the pyramidal tract (HP:0002062)1.48191358
145Abnormality of the dental pulp (HP:0006479)1.47622414
146Tented upper lip vermilion (HP:0010804)1.47360847

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.20224433
2NTRK34.14538312
3MAP3K93.57672223
4DAPK23.08040377
5MAP3K42.97556881
6MARK12.54013692
7EPHA22.34042525
8PAK62.29736698
9MINK12.25090763
10MAP2K72.24370300
11PRKD32.24227268
12KSR22.04756708
13NTRK22.02190168
14RIPK41.99520778
15CAMKK11.88485654
16DAPK11.83109171
17NTRK11.79567587
18MAP2K41.78125044
19CASK1.74395198
20MST1R1.71744708
21LATS11.70726374
22KSR11.69951188
23MET1.68333663
24TNIK1.65539380
25CDK51.56002239
26CDK191.55753880
27TYRO31.54574832
28CAMK1D1.54060366
29SIK21.47231967
30TRIB31.46643262
31MAP3K121.41036963
32MAP3K21.40289102
33TAOK11.28505420
34STK381.25227776
35CDK121.25092307
36PNCK1.23129006
37PLK21.22239202
38OXSR11.22106159
39PRPF4B1.19237262
40MAPK131.15378496
41UHMK11.11872143
42SGK2231.06682880
43SGK4941.06682880
44PRKCG1.02953682
45CCNB10.99919566
46CAMKK20.97516348
47FES0.97109007
48GRK50.96802423
49STK110.94573119
50CAMK10.94430157
51ERBB20.93913910
52SGK20.93653526
53PTK20.92790028
54EEF2K0.90639988
55FRK0.88002753
56CAMK2A0.87942114
57SGK30.85969571
58CDK180.83483570
59RET0.81609868
60CDK150.81360469
61SGK10.80838293
62MAP3K130.80651697
63MARK20.78931104
64NEK10.78733188
65CAMK1G0.78178199
66ARAF0.77458629
67RAF10.76368681
68PAK30.76207543
69AKT30.76137317
70PRKCH0.75315656
71CDK140.74946112
72MAP4K20.74300431
73PKN20.73691645
74CDK11A0.69867675
75LMTK20.68786505
76MAPK150.68235328
77PDPK10.67802889
78STK38L0.67603979
79BMPR20.67522859
80CAMK2B0.67176164
81PDGFRB0.66589077
82PDK10.66367538
83EPHB20.66346644
84PTK2B0.66228666
85WNK30.66184294
86LATS20.66069230
87WNK40.64407278
88PIK3CA0.64160585
89RIPK10.63974762
90PHKG10.62388614
91PHKG20.62388614
92PDGFRA0.62085443
93NEK60.60329121
94MTOR0.60048564
95PINK10.59562884
96ALK0.58204431
97FGFR20.57149522
98DYRK1A0.56708900
99STK30.56214946
100SIK10.55574739
101STK390.55280961
102CAMK40.54594226
103CSNK1G20.53812510
104RPS6KA30.53794164
105DMPK0.52904067
106WNK10.50335929
107BRSK10.50242869
108MAP3K70.50197749
109MAP3K10.50050672
110CAMK2G0.49160148
111ACVR1B0.49060497
112STK240.49019828
113BRD40.48915423
114CDC42BPA0.48710649
115PRKCZ0.46482620
116SIK30.44999089
117GSK3B0.44698716
118FGFR10.44690665
119MAPK100.44222558
120PRKCE0.44064009
121CSNK1E0.43986902
122MAPK80.43145506
123ICK0.42636265
124FYN0.42329522
125DAPK30.42223260
126ROCK10.41946012
127TNK20.41604704
128PRKAA10.41401427
129MAP2K10.40249225
130MAP3K60.40091294
131BCR0.39583525
132FER0.37710039
133FGR0.35024523
134CAMK2D0.34004214

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.34938101
2Synaptic vesicle cycle_Homo sapiens_hsa047212.95691051
3Olfactory transduction_Homo sapiens_hsa047402.83760879
4Circadian entrainment_Homo sapiens_hsa047132.70955755
5Long-term potentiation_Homo sapiens_hsa047202.63909620
6Glutamatergic synapse_Homo sapiens_hsa047242.60493463
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56779668
8GABAergic synapse_Homo sapiens_hsa047272.56349480
9Morphine addiction_Homo sapiens_hsa050322.48591267
10Amphetamine addiction_Homo sapiens_hsa050312.46986225
11Salivary secretion_Homo sapiens_hsa049702.29271939
12Dopaminergic synapse_Homo sapiens_hsa047282.15497600
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.05968093
14Insulin secretion_Homo sapiens_hsa049112.03588244
15Gastric acid secretion_Homo sapiens_hsa049712.01696859
16Cholinergic synapse_Homo sapiens_hsa047251.94859779
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88415224
18Renin secretion_Homo sapiens_hsa049241.86662012
19Oxytocin signaling pathway_Homo sapiens_hsa049211.72450299
20Cocaine addiction_Homo sapiens_hsa050301.69102166
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68491329
22Long-term depression_Homo sapiens_hsa047301.66655734
23Taste transduction_Homo sapiens_hsa047421.59676469
24Serotonergic synapse_Homo sapiens_hsa047261.58951293
25Calcium signaling pathway_Homo sapiens_hsa040201.57722419
26Nitrogen metabolism_Homo sapiens_hsa009101.51360291
27GnRH signaling pathway_Homo sapiens_hsa049121.50551280
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44548725
29Gap junction_Homo sapiens_hsa045401.41720532
30Phototransduction_Homo sapiens_hsa047441.38146362
31Histidine metabolism_Homo sapiens_hsa003401.36693076
32cAMP signaling pathway_Homo sapiens_hsa040241.32659894
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29473788
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23673630
35Type II diabetes mellitus_Homo sapiens_hsa049301.20316529
36Glioma_Homo sapiens_hsa052141.19237645
37Axon guidance_Homo sapiens_hsa043601.17654155
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17130680
39Estrogen signaling pathway_Homo sapiens_hsa049151.15080678
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14195119
41Melanogenesis_Homo sapiens_hsa049161.13451003
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12411487
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11775223
44ErbB signaling pathway_Homo sapiens_hsa040121.11047302
45Collecting duct acid secretion_Homo sapiens_hsa049661.06734563
46Vitamin B6 metabolism_Homo sapiens_hsa007501.05991920
47Dorso-ventral axis formation_Homo sapiens_hsa043201.03822010
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.01015202
49Pancreatic secretion_Homo sapiens_hsa049720.94693547
50Adherens junction_Homo sapiens_hsa045200.92817225
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92735832
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90257370
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.87008518
54Oocyte meiosis_Homo sapiens_hsa041140.86833451
55Thyroid hormone synthesis_Homo sapiens_hsa049180.82639501
56ABC transporters_Homo sapiens_hsa020100.81902363
57Cardiac muscle contraction_Homo sapiens_hsa042600.80691703
58Dilated cardiomyopathy_Homo sapiens_hsa054140.79470292
59Choline metabolism in cancer_Homo sapiens_hsa052310.78874108
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78351643
61Lysine degradation_Homo sapiens_hsa003100.74663156
62MAPK signaling pathway_Homo sapiens_hsa040100.71921416
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70784348
64Protein digestion and absorption_Homo sapiens_hsa049740.70083441
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69742578
66Vibrio cholerae infection_Homo sapiens_hsa051100.68318394
67Arginine biosynthesis_Homo sapiens_hsa002200.68190830
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67638117
69VEGF signaling pathway_Homo sapiens_hsa043700.65664285
70Rap1 signaling pathway_Homo sapiens_hsa040150.64228721
71mTOR signaling pathway_Homo sapiens_hsa041500.61663497
72Ras signaling pathway_Homo sapiens_hsa040140.61603171
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60433035
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60218244
75AMPK signaling pathway_Homo sapiens_hsa041520.60214605
76Phenylalanine metabolism_Homo sapiens_hsa003600.58894487
77Wnt signaling pathway_Homo sapiens_hsa043100.58841453
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.58729076
79Circadian rhythm_Homo sapiens_hsa047100.58457600
80Glucagon signaling pathway_Homo sapiens_hsa049220.58236456
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56601974
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.56478083
83Bile secretion_Homo sapiens_hsa049760.55751316
84beta-Alanine metabolism_Homo sapiens_hsa004100.55356529
85Inositol phosphate metabolism_Homo sapiens_hsa005620.53131780
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52563119
87Alcoholism_Homo sapiens_hsa050340.51910355
88Non-small cell lung cancer_Homo sapiens_hsa052230.51801303
89Endometrial cancer_Homo sapiens_hsa052130.51783077
90Sphingolipid metabolism_Homo sapiens_hsa006000.50843937
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50674912
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49553756
93Arginine and proline metabolism_Homo sapiens_hsa003300.49442063
94Linoleic acid metabolism_Homo sapiens_hsa005910.49335769
95Basal cell carcinoma_Homo sapiens_hsa052170.49126725
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.48166015
97Renal cell carcinoma_Homo sapiens_hsa052110.47981917
98Notch signaling pathway_Homo sapiens_hsa043300.47549584
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47431361
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46327171
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45505573
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45410887
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44837371
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44833834
105Endocytosis_Homo sapiens_hsa041440.43902477
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43200969
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.42378421
108Ovarian steroidogenesis_Homo sapiens_hsa049130.41873788
109Tight junction_Homo sapiens_hsa045300.41822632
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41691687
111African trypanosomiasis_Homo sapiens_hsa051430.41392785
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39289819
113Insulin signaling pathway_Homo sapiens_hsa049100.37875502
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37862689
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36814079
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36127544
117Fatty acid biosynthesis_Homo sapiens_hsa000610.34488834
118Mineral absorption_Homo sapiens_hsa049780.31964138
119Hedgehog signaling pathway_Homo sapiens_hsa043400.31363349
120Prion diseases_Homo sapiens_hsa050200.29858783
121Chemokine signaling pathway_Homo sapiens_hsa040620.28096962
122Hippo signaling pathway_Homo sapiens_hsa043900.26222648
123Type I diabetes mellitus_Homo sapiens_hsa049400.25879176

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