ARHGAP33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants encoding different isoforms have been identified in this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.78492277
2synaptic vesicle maturation (GO:0016188)5.75992888
3locomotory exploration behavior (GO:0035641)5.67554750
4vocalization behavior (GO:0071625)5.55282831
5layer formation in cerebral cortex (GO:0021819)5.49538454
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.45834376
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.38051115
8dendritic spine morphogenesis (GO:0060997)5.33743066
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.29451868
10pyrimidine nucleobase catabolic process (GO:0006208)5.25570284
11regulation of synapse structural plasticity (GO:0051823)5.24418145
12regulation of glutamate receptor signaling pathway (GO:1900449)4.86451745
13protein localization to synapse (GO:0035418)4.81189876
14synaptic vesicle exocytosis (GO:0016079)4.73590802
15cerebellar granule cell differentiation (GO:0021707)4.64643968
16neuron cell-cell adhesion (GO:0007158)4.63324548
17auditory behavior (GO:0031223)4.56365376
18exploration behavior (GO:0035640)4.54878389
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.54854664
20regulation of neuronal synaptic plasticity (GO:0048168)4.48867311
21establishment of mitochondrion localization (GO:0051654)4.48022566
22neuron recognition (GO:0008038)4.47283359
23synaptic vesicle docking involved in exocytosis (GO:0016081)4.45976186
24glutamate secretion (GO:0014047)4.43887279
25regulation of synaptic vesicle exocytosis (GO:2000300)4.43876119
26nucleobase catabolic process (GO:0046113)4.26498740
27ionotropic glutamate receptor signaling pathway (GO:0035235)4.21705915
28cell migration in hindbrain (GO:0021535)4.19431433
29axonal fasciculation (GO:0007413)4.14279259
30neurotransmitter-gated ion channel clustering (GO:0072578)4.08377185
31central nervous system projection neuron axonogenesis (GO:0021952)4.06032222
32mitochondrion transport along microtubule (GO:0047497)4.00402749
33establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.00402749
34dendrite morphogenesis (GO:0048813)3.97018811
35regulation of synapse maturation (GO:0090128)3.94037970
36neurotransmitter secretion (GO:0007269)3.92740641
37regulation of synaptic vesicle transport (GO:1902803)3.87178687
38response to auditory stimulus (GO:0010996)3.85791296
39regulation of dendritic spine morphogenesis (GO:0061001)3.84819619
40synaptic transmission, glutamatergic (GO:0035249)3.76832000
41positive regulation of synapse maturation (GO:0090129)3.74036754
42prepulse inhibition (GO:0060134)3.70544813
43presynaptic membrane assembly (GO:0097105)3.67696014
44neuromuscular process controlling balance (GO:0050885)3.64970520
45positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.62503705
46positive regulation of synaptic transmission, GABAergic (GO:0032230)3.61106713
47transmission of nerve impulse (GO:0019226)3.60846387
48regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.60167963
49positive regulation of membrane potential (GO:0045838)3.58929400
50presynaptic membrane organization (GO:0097090)3.57984797
51response to pheromone (GO:0019236)3.57036389
52neuronal ion channel clustering (GO:0045161)3.56494112
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.56344554
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.53026997
55positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.52339301
56positive regulation of dendritic spine development (GO:0060999)3.52318608
57glutamate receptor signaling pathway (GO:0007215)3.51317824
58gamma-aminobutyric acid transport (GO:0015812)3.50719608
59neuron-neuron synaptic transmission (GO:0007270)3.48667705
60regulation of excitatory postsynaptic membrane potential (GO:0060079)3.48253138
61cellular potassium ion homeostasis (GO:0030007)3.47186110
62dendritic spine organization (GO:0097061)3.43819904
63postsynaptic membrane organization (GO:0001941)3.41957786
64activation of protein kinase A activity (GO:0034199)3.41315465
65long-term memory (GO:0007616)3.40866598
66positive regulation of synapse assembly (GO:0051965)3.40323381
67dopamine receptor signaling pathway (GO:0007212)3.39296924
68mechanosensory behavior (GO:0007638)3.37798665
69G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.37116511
70cerebellar Purkinje cell layer development (GO:0021680)3.36146104
71adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.34345605
72cell-cell junction maintenance (GO:0045217)3.31735187
73regulation of dendritic spine development (GO:0060998)3.30764677
74regulation of synaptic plasticity (GO:0048167)3.30447877
75regulation of postsynaptic membrane potential (GO:0060078)3.30223914
76regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.29713869
77negative regulation of microtubule polymerization (GO:0031115)3.29162352
78proline transport (GO:0015824)3.24997452
79regulation of respiratory gaseous exchange (GO:0043576)3.22702394
80negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.22651887
81neuronal action potential propagation (GO:0019227)3.18298088
82cell differentiation in hindbrain (GO:0021533)3.16108301
83sodium ion export (GO:0071436)3.14929808
84regulation of ARF protein signal transduction (GO:0032012)3.14467952
85regulation of NFAT protein import into nucleus (GO:0051532)3.14338893
86regulation of synaptic transmission, glutamatergic (GO:0051966)3.14307700
87membrane hyperpolarization (GO:0060081)3.12443238
88positive regulation of neurotransmitter secretion (GO:0001956)3.11709387
89positive regulation of neurotransmitter transport (GO:0051590)3.06917821
90synaptic vesicle endocytosis (GO:0048488)3.06781740
91L-amino acid import (GO:0043092)3.06668503
92synapse assembly (GO:0007416)3.06205889
93cerebellar Purkinje cell differentiation (GO:0021702)3.06147764
94positive regulation of dendritic spine morphogenesis (GO:0061003)3.05900003
95central nervous system neuron axonogenesis (GO:0021955)3.04570524
96behavioral defense response (GO:0002209)3.02929348
97behavioral fear response (GO:0001662)3.02929348
98learning (GO:0007612)3.02030298
99establishment of nucleus localization (GO:0040023)3.01728689
100central nervous system myelination (GO:0022010)3.01525429
101axon ensheathment in central nervous system (GO:0032291)3.01525429
102regulation of female receptivity (GO:0045924)3.00571125
103regulation of neurotransmitter secretion (GO:0046928)2.99717701
104cerebellum development (GO:0021549)2.99463484
105neurotransmitter transport (GO:0006836)2.99399534
106clathrin coat assembly (GO:0048268)2.97693002
107intraspecies interaction between organisms (GO:0051703)2.97000255
108social behavior (GO:0035176)2.97000255
109cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.96368458
110regulation of respiratory system process (GO:0044065)2.96228592
111regulation of dendrite morphogenesis (GO:0048814)2.93906163
112cerebral cortex neuron differentiation (GO:0021895)2.92712670
113synapse organization (GO:0050808)2.90786658
114regulation of vesicle fusion (GO:0031338)2.90325917
115amino acid import (GO:0043090)2.89662944
116phosphorelay signal transduction system (GO:0000160)2.89166073
117neuromuscular synaptic transmission (GO:0007274)2.88700777
118cell communication by electrical coupling (GO:0010644)2.87860661
119negative regulation of oligodendrocyte differentiation (GO:0048715)2.86418624
120membrane depolarization (GO:0051899)2.85813398
121regulation of neurotransmitter levels (GO:0001505)2.85109322
122membrane depolarization during action potential (GO:0086010)2.84406573
123negative regulation of axonogenesis (GO:0050771)2.84010588
124positive regulation of dendrite development (GO:1900006)2.83223131
125neuromuscular process (GO:0050905)2.79685798
126axon extension (GO:0048675)2.79137093
127spinal cord development (GO:0021510)2.78344858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.62599496
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09022360
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07992770
4* RARB_27405468_Chip-Seq_BRAIN_Mouse2.98551277
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90404934
6GBX2_23144817_ChIP-Seq_PC3_Human2.89110439
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.85196928
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.84069675
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.84069675
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.81513990
11REST_21632747_ChIP-Seq_MESCs_Mouse2.81006608
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.75822210
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.75477698
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74753931
15DROSHA_22980978_ChIP-Seq_HELA_Human2.68913752
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.65049842
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.61813404
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.58965170
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58689682
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51316118
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51046539
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.50150510
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48725609
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.46935986
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46900439
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.35324370
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.33285639
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.24311014
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.22702013
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99128331
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87501044
32AR_21572438_ChIP-Seq_LNCaP_Human1.79969687
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.76505012
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.75125223
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63173633
36* RING1B_27294783_Chip-Seq_ESCs_Mouse1.61926733
37KDM2B_26808549_Chip-Seq_K562_Human1.59542898
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53341482
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52826259
40RING1B_27294783_Chip-Seq_NPCs_Mouse1.50933854
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50118092
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46053548
43RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.45436660
44P68_20966046_ChIP-Seq_HELA_Human1.42671368
45SMC4_20622854_ChIP-Seq_HELA_Human1.40809722
46EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37326030
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.36398145
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35194127
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33138340
50ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33129515
51CREB1_26743006_Chip-Seq_LNCaP_Human1.32829557
52ZNF274_21170338_ChIP-Seq_K562_Hela1.32436663
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32280052
54TCF7_22412390_ChIP-Seq_EML_Mouse1.29681363
55OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.29546699
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28730822
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27564650
58VDR_21846776_ChIP-Seq_THP-1_Human1.26872953
59TAF15_26573619_Chip-Seq_HEK293_Human1.23743940
60RNF2_27304074_Chip-Seq_NSC_Mouse1.22914000
61P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20873239
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19320809
63MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.18327997
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17045518
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.17004033
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16217233
67RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15473351
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15235875
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.14935325
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.14230582
71AR_19668381_ChIP-Seq_PC3_Human1.14081003
72MYC_22102868_ChIP-Seq_BL_Human1.13481679
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11994599
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11096537
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09765979
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08652773
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07936650
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07150573
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06934783
80SMAD4_21799915_ChIP-Seq_A2780_Human1.06333618
81CTCF_27219007_Chip-Seq_Bcells_Human1.06110243
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05034720
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04970528
84IGF1R_20145208_ChIP-Seq_DFB_Human1.04030515
85TET1_21490601_ChIP-Seq_MESCs_Mouse1.03960897
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02977377
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02945142
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02338303
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.02312255
90SOX3_22085726_ChIP-Seq_NPCs_Mouse1.00337159
91SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99292506
92CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98028868
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96529920
94NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96106429
95GATA1_26923725_Chip-Seq_HPCs_Mouse0.95909657
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95851461
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95599910
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95244737
99BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94286835
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92780354
101AR_25329375_ChIP-Seq_VCAP_Human0.92693953
102SMAD4_21741376_ChIP-Seq_HESCs_Human0.92466261
103SMAD3_21741376_ChIP-Seq_ESCs_Human0.92327905
104RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92162204
105TP53_20018659_ChIP-ChIP_R1E_Mouse0.91969560
106ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91854271
107KDM2B_26808549_Chip-Seq_JURKAT_Human0.91465095
108SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.90905277
109ARNT_22903824_ChIP-Seq_MCF-7_Human0.90580481
110STAT3_23295773_ChIP-Seq_U87_Human0.88893694
111RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88630650
112RACK7_27058665_Chip-Seq_MCF-7_Human0.88128712
113ELF1_20517297_ChIP-Seq_JURKAT_Human0.86611147
114AHR_22903824_ChIP-Seq_MCF-7_Human0.86364000
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86215206
116KLF4_19829295_ChIP-Seq_ESCs_Human0.86137336
117KDM2B_26808549_Chip-Seq_DND41_Human0.84590384
118MYC_27129775_Chip-Seq_CORNEA_Mouse0.84149085
119LXR_22292898_ChIP-Seq_THP-1_Human0.84134008
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84084022
121TP53_23651856_ChIP-Seq_MEFs_Mouse0.83233177
122P300_19829295_ChIP-Seq_ESCs_Human0.83166388
123SA1_27219007_Chip-Seq_Bcells_Human0.83026242
124ELK3_25401928_ChIP-Seq_HUVEC_Human0.82916530
125ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82455385
126TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82002980
127PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81822996
128CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81739217
129OCT4_19829295_ChIP-Seq_ESCs_Human0.81558650
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81470010
131STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80110333
132TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.76182332
133TCF4_23295773_ChIP-Seq_U87_Human0.76147523
134RUNX2_22187159_ChIP-Seq_PCA_Human0.75454692

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.52555032
2MP0003880_abnormal_central_pattern4.25563499
3MP0003635_abnormal_synaptic_transmissio3.95748715
4MP0004270_analgesia3.82178757
5MP0002822_catalepsy3.52385707
6MP0002063_abnormal_learning/memory/cond3.38404183
7MP0005423_abnormal_somatic_nervous3.13138640
8MP0009745_abnormal_behavioral_response3.10225408
9MP0000778_abnormal_nervous_system2.99335459
10MP0002064_seizures2.75751928
11MP0002572_abnormal_emotion/affect_behav2.62197008
12MP0001486_abnormal_startle_reflex2.54978275
13MP0001529_abnormal_vocalization2.50778542
14MP0002734_abnormal_mechanical_nocicepti2.43485427
15MP0001968_abnormal_touch/_nociception2.35052207
16MP0009046_muscle_twitch2.26360907
17MP0004811_abnormal_neuron_physiology2.12970632
18MP0002653_abnormal_ependyma_morphology2.08556182
19MP0002272_abnormal_nervous_system2.03122462
20MP0001440_abnormal_grooming_behavior1.99230705
21MP0009780_abnormal_chondrocyte_physiolo1.98777143
22MP0002557_abnormal_social/conspecific_i1.98513741
23MP0002184_abnormal_innervation1.98098795
24MP0002733_abnormal_thermal_nociception1.96326092
25MP0000955_abnormal_spinal_cord1.89359422
26MP0003329_amyloid_beta_deposits1.87643191
27MP0002249_abnormal_larynx_morphology1.86392356
28MP0004924_abnormal_behavior1.78510113
29MP0005386_behavior/neurological_phenoty1.78510113
30MP0001970_abnormal_pain_threshold1.77936783
31MP0008961_abnormal_basal_metabolism1.74751507
32MP0001984_abnormal_olfaction1.74042395
33MP0000569_abnormal_digit_pigmentation1.69083502
34MP0006276_abnormal_autonomic_nervous1.68220985
35MP0005646_abnormal_pituitary_gland1.67714087
36MP0002735_abnormal_chemical_nociception1.67292456
37MP0008569_lethality_at_weaning1.65281527
38MP0004858_abnormal_nervous_system1.63155058
39MP0004885_abnormal_endolymph1.62371563
40MP0002909_abnormal_adrenal_gland1.60254818
41MP0001501_abnormal_sleep_pattern1.58288130
42MP0002882_abnormal_neuron_morphology1.57933911
43MP0003122_maternal_imprinting1.57213797
44MP0002736_abnormal_nociception_after1.55831529
45MP0002067_abnormal_sensory_capabilities1.55240914
46MP0003123_paternal_imprinting1.54243917
47MP0005499_abnormal_olfactory_system1.52770141
48MP0005394_taste/olfaction_phenotype1.52770141
49MP0005645_abnormal_hypothalamus_physiol1.49771340
50MP0001348_abnormal_lacrimal_gland1.47399740
51MP0002152_abnormal_brain_morphology1.43316062
52MP0002066_abnormal_motor_capabilities/c1.38311305
53MP0000566_synostosis1.34597383
54MP0003879_abnormal_hair_cell1.33155152
55MP0003861_abnormal_nervous_system1.15718780
56MP0006292_abnormal_olfactory_placode1.15453925
57MP0003633_abnormal_nervous_system1.12888178
58MP0000631_abnormal_neuroendocrine_gland1.12073542
59MP0008789_abnormal_olfactory_epithelium1.07715782
60MP0001502_abnormal_circadian_rhythm1.07540715
61MP0005187_abnormal_penis_morphology1.07024527
62MP0002069_abnormal_eating/drinking_beha1.06490683
63MP0000026_abnormal_inner_ear1.01431271
64MP0001905_abnormal_dopamine_level1.00948843
65MP0001177_atelectasis0.99920041
66MP0003631_nervous_system_phenotype0.98782742
67MP0005409_darkened_coat_color0.98014770
68MP0009278_abnormal_bone_marrow0.96045834
69MP0002089_abnormal_postnatal_growth/wei0.95212232
70MP0003787_abnormal_imprinting0.93936518
71MP0003283_abnormal_digestive_organ0.91884203
72MP0001188_hyperpigmentation0.89346716
73MP0004742_abnormal_vestibular_system0.89302441
74MP0003634_abnormal_glial_cell0.86526860
75MP0010030_abnormal_orbit_morphology0.86093988
76MP0002752_abnormal_somatic_nervous0.84217109
77MP0004142_abnormal_muscle_tone0.83968933
78MP0003137_abnormal_impulse_conducting0.79038051
79MP0000049_abnormal_middle_ear0.77970995
80MP0004133_heterotaxia0.76683227
81MP0001346_abnormal_lacrimal_gland0.74689726
82MP0004085_abnormal_heartbeat0.74496196
83MP0000751_myopathy0.74323584
84MP0002638_abnormal_pupillary_reflex0.73786842
85MP0004233_abnormal_muscle_weight0.73064201
86MP0000534_abnormal_ureter_morphology0.72819553
87MP0000604_amyloidosis0.71953641
88MP0005377_hearing/vestibular/ear_phenot0.71934231
89MP0003878_abnormal_ear_physiology0.71934231
90MP0003942_abnormal_urinary_system0.71485685
91MP0003632_abnormal_nervous_system0.71279940
92MP0001943_abnormal_respiration0.70660470
93MP0000920_abnormal_myelination0.70437639
94MP0002116_abnormal_craniofacial_bone0.68055163
95MP0003121_genomic_imprinting0.67280011
96MP0002229_neurodegeneration0.67062929
97MP0008872_abnormal_physiological_respon0.66276389
98MP0003119_abnormal_digestive_system0.66018212
99MP0004130_abnormal_muscle_cell0.65605044
100MP0003385_abnormal_body_wall0.65568403
101MP0003948_abnormal_gas_homeostasis0.64852811
102MP0008874_decreased_physiological_sensi0.64617064
103MP0000537_abnormal_urethra_morphology0.64290376
104MP0010769_abnormal_survival0.64118779
105MP0003172_abnormal_lysosome_physiology0.63963204
106MP0002081_perinatal_lethality0.63902200
107MP0002082_postnatal_lethality0.63676227
108MP0010770_preweaning_lethality0.63676227
109MP0001299_abnormal_eye_distance/0.61508169
110MP0005248_abnormal_Harderian_gland0.61423833
111MP0001664_abnormal_digestion0.61420080
112MP0003075_altered_response_to0.60942013
113MP0002090_abnormal_vision0.60850648
114MP0001963_abnormal_hearing_physiology0.60616780
115MP0010768_mortality/aging0.60163800
116MP0002102_abnormal_ear_morphology0.56131665
117MP0003690_abnormal_glial_cell0.55183107
118MP0002234_abnormal_pharynx_morphology0.54631062
119MP0003938_abnormal_ear_development0.54313144

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.80557739
2Focal motor seizures (HP:0011153)5.52588087
3Focal seizures (HP:0007359)4.93903193
4Visual hallucinations (HP:0002367)4.02010173
5Ankle clonus (HP:0011448)3.94457121
6Epileptic encephalopathy (HP:0200134)3.79794143
7Supranuclear gaze palsy (HP:0000605)3.74778988
8Poor eye contact (HP:0000817)3.46136139
9Broad-based gait (HP:0002136)3.39798426
10Mutism (HP:0002300)3.35598194
11Papilledema (HP:0001085)3.32167273
12Limb dystonia (HP:0002451)3.26746802
13Amyotrophic lateral sclerosis (HP:0007354)3.19273634
14Torticollis (HP:0000473)3.18088745
15Impaired social interactions (HP:0000735)3.11336611
16Abnormal social behavior (HP:0012433)3.11336611
17Impaired vibration sensation in the lower limbs (HP:0002166)3.10844627
18Insomnia (HP:0100785)3.05829490
19Polyphagia (HP:0002591)3.02382591
20Abnormal eating behavior (HP:0100738)2.96195684
21Urinary bladder sphincter dysfunction (HP:0002839)2.95553840
22Urinary urgency (HP:0000012)2.94277565
23Abnormality of the corticospinal tract (HP:0002492)2.84792279
24Progressive cerebellar ataxia (HP:0002073)2.84142256
25Absence seizures (HP:0002121)2.83102346
26Depression (HP:0000716)2.80413930
27Focal dystonia (HP:0004373)2.80386910
28Megalencephaly (HP:0001355)2.78880999
29Spastic gait (HP:0002064)2.78800894
30Termporal pattern (HP:0011008)2.76839861
31Insidious onset (HP:0003587)2.76839861
32Drooling (HP:0002307)2.76162710
33Excessive salivation (HP:0003781)2.76162710
34Action tremor (HP:0002345)2.75519014
35Generalized tonic-clonic seizures (HP:0002069)2.75119429
36Neurofibrillary tangles (HP:0002185)2.71208652
37Turricephaly (HP:0000262)2.65049484
38Febrile seizures (HP:0002373)2.64380790
39Hyperacusis (HP:0010780)2.63894292
40Pointed chin (HP:0000307)2.63638234
41Craniofacial dystonia (HP:0012179)2.59010390
42Hemiparesis (HP:0001269)2.58650914
43Peripheral hypomyelination (HP:0007182)2.58014371
44Dialeptic seizures (HP:0011146)2.57932024
45Amblyopia (HP:0000646)2.56918675
46Abnormality of the aortic arch (HP:0012303)2.53678496
47Cerebral inclusion bodies (HP:0100314)2.50183841
48Abnormality of the lower motor neuron (HP:0002366)2.46024322
49Stereotypic behavior (HP:0000733)2.45855185
50Anxiety (HP:0000739)2.43712915
51Lower limb muscle weakness (HP:0007340)2.43657828
52Truncal ataxia (HP:0002078)2.38768763
53Elfin facies (HP:0004428)2.36297743
54Genetic anticipation (HP:0003743)2.33123446
55Atonic seizures (HP:0010819)2.32312187
56Overriding aorta (HP:0002623)2.28223605
57Retinal dysplasia (HP:0007973)2.27265085
58Dysmetria (HP:0001310)2.24387484
59Lissencephaly (HP:0001339)2.22766737
60Fetal akinesia sequence (HP:0001989)2.22286819
61Sleep apnea (HP:0010535)2.21069230
62Neoplasm of the heart (HP:0100544)2.19993178
63Obstructive sleep apnea (HP:0002870)2.19894536
64Dysdiadochokinesis (HP:0002075)2.18651469
65EEG with generalized epileptiform discharges (HP:0011198)2.17985187
66Aplasia/Hypoplasia of the brainstem (HP:0007362)2.17426508
67Hypoplasia of the brainstem (HP:0002365)2.17426508
68Bronchomalacia (HP:0002780)2.17260644
69Hypsarrhythmia (HP:0002521)2.17117273
70Epileptiform EEG discharges (HP:0011182)2.15267574
71Apathy (HP:0000741)2.15241873
72Postural instability (HP:0002172)2.14757752
73Neuronal loss in central nervous system (HP:0002529)2.12480658
74Hyperventilation (HP:0002883)2.12330434
75Failure to thrive in infancy (HP:0001531)2.09502683
76Akinesia (HP:0002304)2.07788310
77Inappropriate behavior (HP:0000719)2.06957193
78Gaze-evoked nystagmus (HP:0000640)2.06431017
79Ankyloglossia (HP:0010296)2.06014873
80Shallow orbits (HP:0000586)2.04159586
81Clonus (HP:0002169)2.03898601
82Progressive inability to walk (HP:0002505)2.03670354
83Pachygyria (HP:0001302)2.02807635
84Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.02315287
85Lower limb amyotrophy (HP:0007210)2.00773884
86Absent speech (HP:0001344)1.95816045
87Hemiplegia (HP:0002301)1.94657754
88Precocious puberty (HP:0000826)1.93458670
89Morphological abnormality of the inner ear (HP:0011390)1.92408961
90Hypoplasia of the corpus callosum (HP:0002079)1.92213278
91Renovascular hypertension (HP:0100817)1.90046351
92Intention tremor (HP:0002080)1.87588663
93Diminished motivation (HP:0000745)1.87563560
94Annular pancreas (HP:0001734)1.87442341
95Diplopia (HP:0000651)1.87026652
96Abnormality of binocular vision (HP:0011514)1.87026652
97Obsessive-compulsive behavior (HP:0000722)1.86921242
98Broad face (HP:0000283)1.85605323
99High anterior hairline (HP:0009890)1.85220852
100Specific learning disability (HP:0001328)1.84624924
101Hypoventilation (HP:0002791)1.84189602
102Aplasia involving bones of the extremities (HP:0009825)1.83841375
103Aplasia involving bones of the upper limbs (HP:0009823)1.83841375
104Aplasia of the phalanges of the hand (HP:0009802)1.83841375
105Sacral dimple (HP:0000960)1.83047609
106Abnormality of salivation (HP:0100755)1.82559227
107Impaired smooth pursuit (HP:0007772)1.82411031
108Renal duplication (HP:0000075)1.81578173
109Bradykinesia (HP:0002067)1.81276515
110Morphological abnormality of the pyramidal tract (HP:0002062)1.80224624
111Trigonocephaly (HP:0000243)1.79036256
112Neoplasm of the adrenal cortex (HP:0100641)1.78827707
113Abnormality of the diencephalon (HP:0010662)1.78373868
114Sporadic (HP:0003745)1.78334250
115Spinal canal stenosis (HP:0003416)1.78212517
116Degeneration of the lateral corticospinal tracts (HP:0002314)1.77689573
117Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.77689573
118Hepatoblastoma (HP:0002884)1.77389163
119Heterotopia (HP:0002282)1.76162863
120Deep palmar crease (HP:0006191)1.76001185
121Generalized hypotonia (HP:0001290)1.75889337
122Tracheomalacia (HP:0002779)1.74137067
123Megalocornea (HP:0000485)1.73717181
124Abnormality of the astrocytes (HP:0100707)1.73579331
125Shawl scrotum (HP:0000049)1.73292917
126Truncus arteriosus (HP:0001660)1.72262853
127Autism (HP:0000717)1.70100832
128Hyperthyroidism (HP:0000836)1.70074129
129Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.69325135
130Short 4th metacarpal (HP:0010044)1.69325135
131Bowel incontinence (HP:0002607)1.68112818
132Long palpebral fissure (HP:0000637)1.68104804
133Agitation (HP:0000713)1.66850718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.25652336
2EPHA44.02980364
3MAP3K93.89982923
4CAMKK13.08796597
5NTRK32.88476311
6MINK12.79457822
7PASK2.71800979
8KSR12.59996270
9NTRK22.44016569
10MAP3K42.41793277
11DAPK22.39774362
12PAK62.36485173
13SIK32.16082875
14SIK22.09466442
15UHMK12.01628534
16PRKD31.88958801
17MAPK131.85561392
18KSR21.76410919
19TYRO31.62454811
20MAP2K71.58226008
21CDK51.56279625
22NTRK11.38292331
23MAPK151.38152530
24CDK121.36436882
25ICK1.35127176
26DYRK21.30984986
27TNIK1.29261304
28PHKG11.26837236
29PHKG21.26837236
30TAOK11.25334323
31SIK11.25187381
32ERBB31.22184200
33PRPF4B1.20310477
34DAPK11.17750275
35EEF2K1.14575951
36BCR1.14545716
37MARK21.11145131
38CDK181.11063382
39EPHB21.09816059
40MAP2K41.07307184
41TNK21.04878419
42CDK191.02644617
43LATS21.02128420
44CDK141.01055787
45CDK151.00990820
46BRSK10.95384406
47CAMK1D0.92584174
48FES0.90388175
49CSNK1G20.88874649
50STK110.88626288
51CDK11A0.88321133
52PRKCG0.84367576
53PRKCZ0.83424825
54PNCK0.81962465
55FGFR20.80649346
56INSRR0.79607950
57PAK30.78296304
58DYRK1A0.75415949
59CASK0.75265108
60CAMK40.74669453
61MAP3K120.73428153
62PKN20.72957869
63ERBB20.72216311
64PLK20.71540180
65WNK30.71471590
66DYRK1B0.70634504
67RET0.69795566
68SGK4940.69776159
69SGK2230.69776159
70RIPK40.68326691
71MAP3K20.68323420
72SGK20.68293786
73DDR20.64100932
74MTOR0.63988917
75LIMK10.62084885
76ALK0.61552403
77RPS6KA20.57789274
78SCYL20.57573120
79CCNB10.55178580
80STK380.55145242
81MAP3K70.54745259
82MAPK80.54641941
83CAMK10.54600955
84GRK50.54538003
85TRIB30.53388965
86CAMK2A0.53057225
87SMG10.52805667
88NEK60.52657866
89CAMK1G0.52097292
90BRD40.51035529
91PRKCH0.50605844
92MAP3K110.50275448
93SGK10.49972522
94GSK3B0.49103676
95WNK10.47997807
96CSNK1G30.47830433
97PKN10.47699073
98RAF10.46962029
99* FYN0.45847313
100MAP3K60.45536937
101CDC42BPA0.44841860
102HIPK20.44335157
103CAMK2B0.43003914
104IRAK20.42964080
105CSNK1A1L0.42786784
106PRKD20.42376117
107RPS6KA30.42076542
108RPS6KC10.41434113
109RPS6KL10.41434113
110PRKAA10.41262136
111FGFR40.40143207
112OXSR10.40038645
113MAPK100.40033813
114PDGFRA0.39217339
115BRAF0.39077979
116ROCK20.38827502
117MAPK90.38232445
118TESK10.37488240
119LMTK20.37469015
120TESK20.37399481
121ARAF0.37232225
122CDK20.37047259
123MAPK40.36259390
124MAP3K100.33821713
125MAP2K10.33429167
126CAMKK20.33106145
127ROCK10.32692111
128MAPK120.32334861
129SGK30.31125097
130RIPK10.30898774
131PDK10.30411071

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.01328812
2Olfactory transduction_Homo sapiens_hsa047402.97434927
3Synaptic vesicle cycle_Homo sapiens_hsa047212.85945663
4Circadian entrainment_Homo sapiens_hsa047132.59317829
5GABAergic synapse_Homo sapiens_hsa047272.52294446
6Glutamatergic synapse_Homo sapiens_hsa047242.46524314
7Morphine addiction_Homo sapiens_hsa050322.42951347
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.29946266
9Dopaminergic synapse_Homo sapiens_hsa047282.26123696
10Long-term potentiation_Homo sapiens_hsa047202.24209694
11Amphetamine addiction_Homo sapiens_hsa050312.19904052
12Cholinergic synapse_Homo sapiens_hsa047252.07368422
13Axon guidance_Homo sapiens_hsa043602.05419639
14Cocaine addiction_Homo sapiens_hsa050302.02804830
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93304879
16Salivary secretion_Homo sapiens_hsa049701.85543177
17Gap junction_Homo sapiens_hsa045401.75504352
18Insulin secretion_Homo sapiens_hsa049111.74024857
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73457648
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72314021
21Gastric acid secretion_Homo sapiens_hsa049711.71936059
22Oxytocin signaling pathway_Homo sapiens_hsa049211.69158319
23Renin secretion_Homo sapiens_hsa049241.55222026
24Serotonergic synapse_Homo sapiens_hsa047261.50526066
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49073525
26GnRH signaling pathway_Homo sapiens_hsa049121.47046234
27Long-term depression_Homo sapiens_hsa047301.42814376
28Glioma_Homo sapiens_hsa052141.32147128
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31381799
30ErbB signaling pathway_Homo sapiens_hsa040121.29301907
31Taste transduction_Homo sapiens_hsa047421.28567111
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28194672
33Calcium signaling pathway_Homo sapiens_hsa040201.28045660
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.24955330
35Type II diabetes mellitus_Homo sapiens_hsa049301.24372140
36cAMP signaling pathway_Homo sapiens_hsa040241.21121885
37Estrogen signaling pathway_Homo sapiens_hsa049151.19796579
38Melanogenesis_Homo sapiens_hsa049161.19087594
39Dorso-ventral axis formation_Homo sapiens_hsa043201.18564705
40Oocyte meiosis_Homo sapiens_hsa041141.07445128
41Endometrial cancer_Homo sapiens_hsa052131.04290371
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01641800
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97251526
44Neurotrophin signaling pathway_Homo sapiens_hsa047220.96384124
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.95140824
46VEGF signaling pathway_Homo sapiens_hsa043700.94721023
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90031298
48Colorectal cancer_Homo sapiens_hsa052100.89721271
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89698012
50Renal cell carcinoma_Homo sapiens_hsa052110.89055497
51Alcoholism_Homo sapiens_hsa050340.87909111
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86772572
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82970079
54Non-small cell lung cancer_Homo sapiens_hsa052230.82452383
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79475703
56Choline metabolism in cancer_Homo sapiens_hsa052310.79301931
57MAPK signaling pathway_Homo sapiens_hsa040100.78313525
58Lysine degradation_Homo sapiens_hsa003100.77788487
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75373938
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.75157390
61Collecting duct acid secretion_Homo sapiens_hsa049660.74181367
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73685638
63mTOR signaling pathway_Homo sapiens_hsa041500.73596969
64Wnt signaling pathway_Homo sapiens_hsa043100.71475104
65Inositol phosphate metabolism_Homo sapiens_hsa005620.70771449
66Phototransduction_Homo sapiens_hsa047440.68897908
67Dilated cardiomyopathy_Homo sapiens_hsa054140.67873387
68Endocytosis_Homo sapiens_hsa041440.67682512
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.67251620
70Ras signaling pathway_Homo sapiens_hsa040140.66510713
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65696035
72Cardiac muscle contraction_Homo sapiens_hsa042600.65326286
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64986266
74Rap1 signaling pathway_Homo sapiens_hsa040150.64713217
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64304499
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62765521
77Nitrogen metabolism_Homo sapiens_hsa009100.61843493
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60183974
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59336416
80Basal cell carcinoma_Homo sapiens_hsa052170.59283752
81Thyroid hormone synthesis_Homo sapiens_hsa049180.58771799
82Pancreatic secretion_Homo sapiens_hsa049720.58356395
83Prolactin signaling pathway_Homo sapiens_hsa049170.57951880
84Vibrio cholerae infection_Homo sapiens_hsa051100.57092765
85Hedgehog signaling pathway_Homo sapiens_hsa043400.56609626
86Hippo signaling pathway_Homo sapiens_hsa043900.56248601
87Prion diseases_Homo sapiens_hsa050200.55076690
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52068637
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51830300
90Insulin signaling pathway_Homo sapiens_hsa049100.51320553
91Vitamin B6 metabolism_Homo sapiens_hsa007500.50579607
92mRNA surveillance pathway_Homo sapiens_hsa030150.49951524
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48765056
94Chemokine signaling pathway_Homo sapiens_hsa040620.48633397
95Glucagon signaling pathway_Homo sapiens_hsa049220.45879392
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44336219
97Notch signaling pathway_Homo sapiens_hsa043300.43746821
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.43071006
99Acute myeloid leukemia_Homo sapiens_hsa052210.42682956
100B cell receptor signaling pathway_Homo sapiens_hsa046620.42604211
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40351500
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39592005
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.38610399
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38510515
105Bile secretion_Homo sapiens_hsa049760.38152675
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36079313
107Type I diabetes mellitus_Homo sapiens_hsa049400.33605328
108AMPK signaling pathway_Homo sapiens_hsa041520.33195247
109Chronic myeloid leukemia_Homo sapiens_hsa052200.32787298
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32586831
111Tight junction_Homo sapiens_hsa045300.32556827

Most similar genes based on co-expression Upload to Enrichr

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