ARHGAP35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)4.66409034
2layer formation in cerebral cortex (GO:0021819)4.37509210
3synaptic vesicle maturation (GO:0016188)4.34198180
4regulation of short-term neuronal synaptic plasticity (GO:0048172)3.97723712
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.85177359
6dendritic spine morphogenesis (GO:0060997)3.72110128
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.72041562
8dendrite morphogenesis (GO:0048813)3.67494243
9vocalization behavior (GO:0071625)3.59396390
10pyrimidine nucleobase catabolic process (GO:0006208)3.57815386
11neuron cell-cell adhesion (GO:0007158)3.56206775
12cell migration in hindbrain (GO:0021535)3.55462235
13exploration behavior (GO:0035640)3.51995952
14glutamate secretion (GO:0014047)3.51416414
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.43093067
16planar cell polarity pathway involved in neural tube closure (GO:0090179)3.34748267
17axonal fasciculation (GO:0007413)3.32626401
18regulation of synaptic vesicle exocytosis (GO:2000300)3.28220802
19synaptic vesicle docking involved in exocytosis (GO:0016081)3.24626283
20protein localization to synapse (GO:0035418)3.21649462
21neuron recognition (GO:0008038)3.20923050
22regulation of glutamate receptor signaling pathway (GO:1900449)3.19000891
23regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.15512465
24adherens junction assembly (GO:0034333)3.14983316
25embryonic retina morphogenesis in camera-type eye (GO:0060059)3.12064099
26establishment of nucleus localization (GO:0040023)3.11922971
27cell communication by electrical coupling (GO:0010644)3.08303476
28cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.07153387
29cell-substrate adherens junction assembly (GO:0007045)3.00924690
30focal adhesion assembly (GO:0048041)3.00924690
31synaptic vesicle exocytosis (GO:0016079)2.99945614
32regulation of synapse structural plasticity (GO:0051823)2.99939496
33gamma-aminobutyric acid transport (GO:0015812)2.97426524
34neurotransmitter-gated ion channel clustering (GO:0072578)2.94722718
35central nervous system projection neuron axonogenesis (GO:0021952)2.94392822
36neurotransmitter secretion (GO:0007269)2.94313948
37desmosome organization (GO:0002934)2.93388637
38semaphorin-plexin signaling pathway (GO:0071526)2.89530149
39nucleobase catabolic process (GO:0046113)2.87640505
40neuromuscular process controlling balance (GO:0050885)2.85591412
41proline transport (GO:0015824)2.81555269
42activation of protein kinase A activity (GO:0034199)2.80669737
43postsynaptic membrane organization (GO:0001941)2.79950807
44cell-substrate junction assembly (GO:0007044)2.79526863
45regulation of neuronal synaptic plasticity (GO:0048168)2.76181180
46innervation (GO:0060384)2.76142723
47cytoskeletal anchoring at plasma membrane (GO:0007016)2.75844031
48cerebellar Purkinje cell layer development (GO:0021680)2.75514603
49regulation of synaptic vesicle transport (GO:1902803)2.74181412
50regulation of long-term neuronal synaptic plasticity (GO:0048169)2.71415183
51cerebellar Purkinje cell differentiation (GO:0021702)2.70528272
52axon extension (GO:0048675)2.70410131
53embryonic camera-type eye morphogenesis (GO:0048596)2.70273820
54protein retention in ER lumen (GO:0006621)2.68242402
55apical protein localization (GO:0045176)2.66933048
56sodium ion export (GO:0071436)2.66360187
57negative regulation of fatty acid transport (GO:2000192)2.64458854
58epithelial cell-cell adhesion (GO:0090136)2.64272693
59cell communication involved in cardiac conduction (GO:0086065)2.63889384
60positive regulation of synapse maturation (GO:0090129)2.63315255
61paraxial mesoderm development (GO:0048339)2.61453142
62regulation of axon extension involved in axon guidance (GO:0048841)2.60170766
63myelination in peripheral nervous system (GO:0022011)2.59755583
64peripheral nervous system axon ensheathment (GO:0032292)2.59755583
65maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.59721491
66negative regulation of catenin import into nucleus (GO:0035414)2.59561868
67regulation of glucose import in response to insulin stimulus (GO:2001273)2.58674801
68COPI coating of Golgi vesicle (GO:0048205)2.58576514
69Golgi transport vesicle coating (GO:0048200)2.58576514
70negative regulation of sodium ion transport (GO:0010766)2.55024485
71retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.53404185
72vesicle transport along microtubule (GO:0047496)2.52455427
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.51998442
74ionotropic glutamate receptor signaling pathway (GO:0035235)2.50879631
75skin morphogenesis (GO:0043589)2.50042638
76regulation of dendritic spine morphogenesis (GO:0061001)2.49875227
77positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.49271265
78organelle transport along microtubule (GO:0072384)2.48480338
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.47446010
80embryonic eye morphogenesis (GO:0048048)2.46282337
81regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.45647493
82hemidesmosome assembly (GO:0031581)2.45396219
83eye morphogenesis (GO:0048592)2.43237618
84auditory behavior (GO:0031223)2.42137395
85dendritic spine organization (GO:0097061)2.42000495
86insulin-like growth factor receptor signaling pathway (GO:0048009)2.41923607
87regulation of axon guidance (GO:1902667)2.41271556
88alanine transport (GO:0032328)2.40954340
89plasma membrane repair (GO:0001778)2.40889096
90regulation of clathrin-mediated endocytosis (GO:2000369)2.40624115
91positive regulation of axon extension (GO:0045773)2.39898908
92protein targeting to plasma membrane (GO:0072661)2.39455530
93Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.38962198
94protein localization to endosome (GO:0036010)2.38554291
95synapse organization (GO:0050808)2.38520192
96cell-cell junction maintenance (GO:0045217)2.38074245
97central nervous system neuron axonogenesis (GO:0021955)2.36620189
98camera-type eye morphogenesis (GO:0048593)2.35659537
99presynaptic membrane assembly (GO:0097105)2.33883673
100mitochondrion transport along microtubule (GO:0047497)2.33110622
101establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.33110622
102cellular potassium ion homeostasis (GO:0030007)2.33057150
103neuron projection extension (GO:1990138)2.31631946
104regulation of establishment of planar polarity (GO:0090175)2.31418061
105membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.30062884
106cerebellar granule cell differentiation (GO:0021707)2.29053072
107neuron projection morphogenesis (GO:0048812)2.29023926
108asymmetric protein localization (GO:0008105)2.28769453
109myoblast fusion (GO:0007520)2.28455978
110synapse assembly (GO:0007416)2.28399470
111regulation of NFAT protein import into nucleus (GO:0051532)2.27949607
112receptor recycling (GO:0001881)2.27652960
113regulation of ARF protein signal transduction (GO:0032012)2.27200817
114dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.27183255
115glucocorticoid receptor signaling pathway (GO:0042921)2.26941637
116basement membrane organization (GO:0071711)2.26450384
117endothelial cell chemotaxis (GO:0035767)2.24771528
118regulation of early endosome to late endosome transport (GO:2000641)2.24652605
119amino acid import (GO:0043090)2.23869954
120mating behavior (GO:0007617)2.22768501
121neuromuscular process (GO:0050905)2.22546135
122G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.22034609
123NLS-bearing protein import into nucleus (GO:0006607)2.22027603
124dicarboxylic acid biosynthetic process (GO:0043650)2.20645735
125anterior/posterior axis specification, embryo (GO:0008595)2.19835298
126activation of Rac GTPase activity (GO:0032863)2.19240519
127positive regulation of dendritic spine development (GO:0060999)2.18225085
128synaptic transmission, glutamatergic (GO:0035249)2.18036949
129cochlea morphogenesis (GO:0090103)2.17911130
130glutamate receptor signaling pathway (GO:0007215)2.17802677
131negative regulation of dendrite morphogenesis (GO:0050774)2.17453604
132neurotransmitter transport (GO:0006836)2.16944440
133convergent extension (GO:0060026)2.16698463
134regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.16620431
135negative regulation of cell size (GO:0045792)2.16618232
136developmental cell growth (GO:0048588)2.16181962
137neuronal ion channel clustering (GO:0045161)2.15236432
138glial cell proliferation (GO:0014009)2.14570510
139positive regulation of membrane potential (GO:0045838)2.14096993
140regulation of excitatory postsynaptic membrane potential (GO:0060079)2.13940659
141regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.13262952
142regulation of nucleobase-containing compound transport (GO:0032239)2.13123664
143hippo signaling (GO:0035329)2.13098209
144nucleus localization (GO:0051647)2.13009773
145cellular sodium ion homeostasis (GO:0006883)2.12998088
146neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.12723431
147notochord development (GO:0030903)2.12456838
148adherens junction organization (GO:0034332)2.12313629
149establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.11896250
150prepulse inhibition (GO:0060134)2.11768686
151regulation of neuron migration (GO:2001222)2.11703812
152regulation of dendritic spine development (GO:0060998)2.11641922
153positive regulation of fatty acid beta-oxidation (GO:0032000)2.11601837
154homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.11520863
155regulation of fatty acid beta-oxidation (GO:0031998)2.10621495
156peptidyl-lysine dimethylation (GO:0018027)2.09248634
157positive regulation of glucose import (GO:0046326)2.07418249
158neural tube development (GO:0021915)2.07337977
159syncytium formation by plasma membrane fusion (GO:0000768)2.06411059
160cellular response to prostaglandin stimulus (GO:0071379)2.03566868
161nuclear pore complex assembly (GO:0051292)2.02869662
162positive regulation of glucose transport (GO:0010828)2.02831009
163cell adhesion mediated by integrin (GO:0033627)2.02409742
164morphogenesis of an epithelial sheet (GO:0002011)2.01347689
165cell migration involved in sprouting angiogenesis (GO:0002042)2.01344589
166establishment or maintenance of bipolar cell polarity (GO:0061245)2.00326191
167establishment or maintenance of apical/basal cell polarity (GO:0035088)2.00326191
168dopamine receptor signaling pathway (GO:0007212)2.00016327

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.42702657
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.93785908
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.48197698
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.46887110
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.35182023
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29393504
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29393504
8GBX2_23144817_ChIP-Seq_PC3_Human2.27615338
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26115183
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.24438461
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18737533
12DROSHA_22980978_ChIP-Seq_HELA_Human2.09880529
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06591150
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05609786
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.05126790
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05002094
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04500916
18MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94601115
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93678593
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87421166
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.87324540
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87118152
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87012830
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86594952
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.85809685
26RARB_27405468_Chip-Seq_BRAIN_Mouse1.83343000
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.78223259
28CLOCK_20551151_ChIP-Seq_293T_Human1.74041122
29REST_21632747_ChIP-Seq_MESCs_Mouse1.73357642
30AR_21572438_ChIP-Seq_LNCaP_Human1.71245093
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.68422687
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67079811
33RACK7_27058665_Chip-Seq_MCF-7_Human1.66859261
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63656115
35LXR_22292898_ChIP-Seq_THP-1_Human1.61940967
36P300_27058665_Chip-Seq_ZR-75-30cells_Human1.58132409
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.57510819
38SOX9_24532713_ChIP-Seq_HFSC_Mouse1.56878666
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56328144
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55884185
41RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.53507267
42ZNF263_19887448_ChIP-Seq_K562_Human1.49801880
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.47756611
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45741420
45ZNF274_21170338_ChIP-Seq_K562_Hela1.45069910
46KDM2B_26808549_Chip-Seq_K562_Human1.44636529
47NFIB_24661679_ChIP-Seq_LUNG_Mouse1.42886531
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.42243327
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.42013770
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.40341980
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40118099
52EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39952176
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39464504
54TCF7_22412390_ChIP-Seq_EML_Mouse1.38631810
55ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38076936
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38072702
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37390260
58DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35633118
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.35329840
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34807109
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34685715
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34512809
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33326289
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.33192973
65KDM2B_26808549_Chip-Seq_DND41_Human1.32847547
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.32316400
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.30604858
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30123520
69AHR_22903824_ChIP-Seq_MCF-7_Human1.29213246
70AR_19668381_ChIP-Seq_PC3_Human1.27793596
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27783844
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.26822287
73SMAD4_21799915_ChIP-Seq_A2780_Human1.26569536
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25818616
75ISL1_27105846_Chip-Seq_CPCs_Mouse1.24457194
76EP300_21415370_ChIP-Seq_HL-1_Mouse1.24365151
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23183958
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22513730
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22077983
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21697963
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.21319895
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19947551
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18689764
84TBX20_22080862_ChIP-Seq_HEART_Mouse1.18639213
85TBX20_22328084_ChIP-Seq_HEART_Mouse1.18639213
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18314120
87TET1_21490601_ChIP-Seq_MESCs_Mouse1.16826334
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15946066
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14985946
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14900168
91CREB1_26743006_Chip-Seq_LNCaP_Human1.14842490
92SMAD4_21741376_ChIP-Seq_HESCs_Human1.14286511
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.13814756
94TP53_23651856_ChIP-Seq_MEFs_Mouse1.13704385
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13612440
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13202897
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13166118
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12549741
99EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11488371
100YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10722688
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10462879
102SMC4_20622854_ChIP-Seq_HELA_Human1.09238428
103TP53_16413492_ChIP-PET_HCT116_Human1.08961374
104HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08847965
105ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07478147
106STAT3_23295773_ChIP-Seq_U87_Human1.07437461
107CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07428222
108SMAD3_21741376_ChIP-Seq_EPCs_Human1.06629491
109DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05131074
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.04675372
111RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02494918
112HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02233360
113RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01926807
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01298130
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01177050
116TP53_22127205_ChIP-Seq_IMR90_Human1.01111988
117ESR1_20079471_ChIP-ChIP_T-47D_Human1.01057028
118FOXA2_19822575_ChIP-Seq_HepG2_Human1.00807532
119TP53_20018659_ChIP-ChIP_R1E_Mouse1.00016548
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99727499
121SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99723860
122CTCF_27219007_Chip-Seq_Bcells_Human0.99350399
123RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98683084
124UBF1/2_26484160_Chip-Seq_HMECs_Human0.98538489
125SMAD3_21741376_ChIP-Seq_HESCs_Human0.97777373
126KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96505065
127OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96240441
128TCF4_18268006_ChIP-ChIP_LS174T_Human0.95692932
129SALL1_21062744_ChIP-ChIP_HESCs_Human0.95609438
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94271944
131BCAT_22108803_ChIP-Seq_LS180_Human0.93848712
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93128606
133TRIM28_21343339_ChIP-Seq_HEK293_Human0.92506286
134OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92377361
135CBX2_27304074_Chip-Seq_ESCs_Mouse0.92260724
136FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91964296
137KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91886611
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90988190
139SMAD3_21741376_ChIP-Seq_ESCs_Human0.90212584
140KDM2B_26808549_Chip-Seq_JURKAT_Human0.89740029
141TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88598573
142MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88594481

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.40319951
2MP0008438_abnormal_cutaneous_collagen2.94496827
3MP0004270_analgesia2.82705583
4MP0005409_darkened_coat_color2.71049500
5MP0003635_abnormal_synaptic_transmissio2.65578069
6MP0009780_abnormal_chondrocyte_physiolo2.50372159
7MP0003880_abnormal_central_pattern2.46745358
8MP0000778_abnormal_nervous_system2.31075693
9MP0004858_abnormal_nervous_system2.21461884
10MP0003566_abnormal_cell_adhesion2.14626823
11MP0002063_abnormal_learning/memory/cond2.08941209
12MP0005257_abnormal_intraocular_pressure2.03457114
13MP0005623_abnormal_meninges_morphology1.95710683
14MP0003705_abnormal_hypodermis_morpholog1.91246786
15MP0000566_synostosis1.84708605
16MP0005275_abnormal_skin_tensile1.74873107
17MP0009745_abnormal_behavioral_response1.73233162
18MP0005423_abnormal_somatic_nervous1.72299275
19MP0002064_seizures1.68457103
20MP0003091_abnormal_cell_migration1.67045007
21MP0000569_abnormal_digit_pigmentation1.64850744
22MP0009046_muscle_twitch1.64606671
23MP0003122_maternal_imprinting1.63921685
24MP0003283_abnormal_digestive_organ1.63589791
25MP0010352_gastrointestinal_tract_polyps1.63179961
26MP0000537_abnormal_urethra_morphology1.63167080
27MP0002734_abnormal_mechanical_nocicepti1.61157155
28MP0002184_abnormal_innervation1.59354998
29MP0005248_abnormal_Harderian_gland1.58524371
30MP0005187_abnormal_penis_morphology1.58490941
31MP0002877_abnormal_melanocyte_morpholog1.58347715
32MP0001958_emphysema1.56745757
33MP0004885_abnormal_endolymph1.55461280
34MP0000955_abnormal_spinal_cord1.53492037
35MP0000579_abnormal_nail_morphology1.52388496
36MP0001299_abnormal_eye_distance/1.51863696
37MP0002572_abnormal_emotion/affect_behav1.51686223
38MP0001849_ear_inflammation1.49805146
39MP0001486_abnormal_startle_reflex1.49625576
40MP0009053_abnormal_anal_canal1.49366750
41MP0004811_abnormal_neuron_physiology1.48327809
42MP0001348_abnormal_lacrimal_gland1.45642799
43MP0000733_abnormal_muscle_development1.45079775
44MP0001968_abnormal_touch/_nociception1.43562896
45MP0002909_abnormal_adrenal_gland1.42297533
46MP0000534_abnormal_ureter_morphology1.36864505
47MP0000751_myopathy1.36337083
48MP0009384_cardiac_valve_regurgitation1.32552128
49MP0004233_abnormal_muscle_weight1.31629518
50MP0004185_abnormal_adipocyte_glucose1.30986747
51MP0002557_abnormal_social/conspecific_i1.30938766
52MP0003329_amyloid_beta_deposits1.30797033
53MP0003385_abnormal_body_wall1.29162332
54MP0002139_abnormal_hepatobiliary_system1.25283312
55MP0003119_abnormal_digestive_system1.25254124
56MP0000462_abnormal_digestive_system1.24828765
57MP0010368_abnormal_lymphatic_system1.23927038
58MP0002882_abnormal_neuron_morphology1.23255028
59MP0002272_abnormal_nervous_system1.23112751
60MP0002733_abnormal_thermal_nociception1.22783641
61MP0002152_abnormal_brain_morphology1.21720200
62MP0000762_abnormal_tongue_morphology1.21587535
63MP0004264_abnormal_extraembryonic_tissu1.19938349
64MP0002653_abnormal_ependyma_morphology1.19832497
65MP0006276_abnormal_autonomic_nervous1.16270106
66MP0003861_abnormal_nervous_system1.15709068
67MP0003115_abnormal_respiratory_system1.15537384
68MP0003941_abnormal_skin_development1.13893187
69MP0002067_abnormal_sensory_capabilities1.13707074
70MP0005394_taste/olfaction_phenotype1.13358320
71MP0005499_abnormal_olfactory_system1.13358320
72MP0001440_abnormal_grooming_behavior1.11950042
73MP0005670_abnormal_white_adipose1.11287947
74MP0003942_abnormal_urinary_system1.10259349
75MP0002060_abnormal_skin_morphology1.10164493
76MP0005666_abnormal_adipose_tissue1.09567933
77MP0000003_abnormal_adipose_tissue1.08539865
78MP0008569_lethality_at_weaning1.06615731
79MP0008961_abnormal_basal_metabolism1.06613129
80MP0003279_aneurysm1.06080867
81MP0010234_abnormal_vibrissa_follicle1.05895326
82MP0004130_abnormal_muscle_cell1.05437783
83MP0004087_abnormal_muscle_fiber1.05065071
84MP0003123_paternal_imprinting1.03751537
85MP0001177_atelectasis1.03711772
86MP0003890_abnormal_embryonic-extraembry1.02565906
87MP0004924_abnormal_behavior1.02304314
88MP0005386_behavior/neurological_phenoty1.02304314
89MP0003879_abnormal_hair_cell1.00827295
90MP0005360_urolithiasis1.00611027
91MP0000747_muscle_weakness1.00578881
92MP0002796_impaired_skin_barrier0.99622113
93MP0002009_preneoplasia0.99390202
94MP0010630_abnormal_cardiac_muscle0.98307272
95MP0002066_abnormal_motor_capabilities/c0.97415102
96MP0006138_congestive_heart_failure0.97117490
97MP0005375_adipose_tissue_phenotype0.96547384
98MP0002234_abnormal_pharynx_morphology0.95717552
99MP0003137_abnormal_impulse_conducting0.95166526
100MP0003252_abnormal_bile_duct0.94833638
101MP0002837_dystrophic_cardiac_calcinosis0.93414079
102MP0000759_abnormal_skeletal_muscle0.92999246
103MP0010030_abnormal_orbit_morphology0.91751705
104MP0003935_abnormal_craniofacial_develop0.91071906
105MP0004145_abnormal_muscle_electrophysio0.90990831
106MP0002249_abnormal_larynx_morphology0.90156994
107MP0000428_abnormal_craniofacial_morphol0.88821314
108MP0004272_abnormal_basement_membrane0.88798165
109MP0001970_abnormal_pain_threshold0.88597744
110MP0005451_abnormal_body_composition0.88038278
111MP0005076_abnormal_cell_differentiation0.87495793
112MP0005085_abnormal_gallbladder_physiolo0.87049016
113MP0002697_abnormal_eye_size0.86988679
114MP0002233_abnormal_nose_morphology0.86639503
115MP0002735_abnormal_chemical_nociception0.86543983
116MP0000767_abnormal_smooth_muscle0.86510547
117MP0000432_abnormal_head_morphology0.85816086
118MP0001984_abnormal_olfaction0.84683828
119MP0000631_abnormal_neuroendocrine_gland0.84199184
120MP0003755_abnormal_palate_morphology0.84193047
121MP0000467_abnormal_esophagus_morphology0.83743977
122MP0002896_abnormal_bone_mineralization0.83550433
123MP0004085_abnormal_heartbeat0.82650541
124MP0003937_abnormal_limbs/digits/tail_de0.82248624
125MP0002089_abnormal_postnatal_growth/wei0.81468391
126MP0003634_abnormal_glial_cell0.81291728
127MP0003632_abnormal_nervous_system0.80993377
128MP0003453_abnormal_keratinocyte_physiol0.80503401
129MP0005508_abnormal_skeleton_morphology0.79935809
130MP0008789_abnormal_olfactory_epithelium0.78793332
131MP0002098_abnormal_vibrissa_morphology0.78517609
132MP0002108_abnormal_muscle_morphology0.78505083
133MP0005023_abnormal_wound_healing0.77402958
134MP0000678_abnormal_parathyroid_gland0.76840917
135MP0009250_abnormal_appendicular_skeleto0.75629664
136MP0002081_perinatal_lethality0.75559710
137MP0005365_abnormal_bile_salt0.75267417
138MP0005503_abnormal_tendon_morphology0.74488254
139MP0003868_abnormal_feces_composition0.74308176
140MP0001915_intracranial_hemorrhage0.73765325
141MP0002114_abnormal_axial_skeleton0.72648513
142MP0002116_abnormal_craniofacial_bone0.72283336
143MP0004215_abnormal_myocardial_fiber0.71791310
144MP0009672_abnormal_birth_weight0.71764747
145MP0002752_abnormal_somatic_nervous0.71460477
146MP0002069_abnormal_eating/drinking_beha0.70719675
147MP0005646_abnormal_pituitary_gland0.70600164
148MP0004036_abnormal_muscle_relaxation0.70107192
149MP0001346_abnormal_lacrimal_gland0.69303925
150MP0003938_abnormal_ear_development0.69118378
151MP0001879_abnormal_lymphatic_vessel0.67681532

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.51732479
2Myokymia (HP:0002411)3.16320275
3Action tremor (HP:0002345)3.09587717
4Premature rupture of membranes (HP:0001788)3.08000837
5Focal seizures (HP:0007359)2.92949537
6Abnormality of the lower motor neuron (HP:0002366)2.79851780
7Focal motor seizures (HP:0011153)2.62792552
8Insidious onset (HP:0003587)2.60672502
9Termporal pattern (HP:0011008)2.60672502
10Shallow orbits (HP:0000586)2.60403241
11Broad face (HP:0000283)2.58977235
12Arterial tortuosity (HP:0005116)2.58937811
13Macroorchidism (HP:0000053)2.56630508
14Vascular tortuosity (HP:0004948)2.52417524
15Genetic anticipation (HP:0003743)2.48609032
16Drooling (HP:0002307)2.48507467
17Excessive salivation (HP:0003781)2.48507467
18Ulnar bowing (HP:0003031)2.48274652
19Cerebral aneurysm (HP:0004944)2.47287272
20Progressive cerebellar ataxia (HP:0002073)2.37512181
21Visual hallucinations (HP:0002367)2.35421599
22Hepatoblastoma (HP:0002884)2.34583032
23Atrophic scars (HP:0001075)2.33311738
24Neonatal short-limb short stature (HP:0008921)2.32365665
25Short 4th metacarpal (HP:0010044)2.31374230
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.31374230
27Turricephaly (HP:0000262)2.27809786
28Vertebral arch anomaly (HP:0008438)2.24875224
29Urinary bladder sphincter dysfunction (HP:0002839)2.23103434
30Pseudobulbar signs (HP:0002200)2.22799210
31Megalencephaly (HP:0001355)2.19821866
32Asymmetry of the thorax (HP:0001555)2.19622182
33Lymphangioma (HP:0100764)2.19267265
34Abnormality of the 4th metacarpal (HP:0010012)2.19081684
35Abnormality of the distal phalanx of the thumb (HP:0009617)2.18868662
36Elfin facies (HP:0004428)2.15604831
37Aplasia involving bones of the extremities (HP:0009825)2.14792411
38Aplasia involving bones of the upper limbs (HP:0009823)2.14792411
39Aplasia of the phalanges of the hand (HP:0009802)2.14792411
40Renovascular hypertension (HP:0100817)2.14704962
41Ankle clonus (HP:0011448)2.12014540
42Flat acetabular roof (HP:0003180)2.11560911
43Impaired vibration sensation in the lower limbs (HP:0002166)2.11348008
44Aqueductal stenosis (HP:0002410)2.10601942
45Abnormality of the corticospinal tract (HP:0002492)2.09057321
46Hyperacusis (HP:0010780)2.07525426
47Dysdiadochokinesis (HP:0002075)2.07131249
48Insomnia (HP:0100785)2.06854505
49Renal duplication (HP:0000075)2.05653474
50Dysmetric saccades (HP:0000641)2.05319150
51Supranuclear gaze palsy (HP:0000605)2.04609210
52Wormian bones (HP:0002645)2.04504113
53Lower limb amyotrophy (HP:0007210)2.03627329
54Advanced eruption of teeth (HP:0006288)2.02954594
55Bronchomalacia (HP:0002780)2.01159028
56Fragile skin (HP:0001030)2.00390143
57Distal lower limb amyotrophy (HP:0008944)1.97952587
58Abnormality of the astrocytes (HP:0100707)1.97893199
59Astrocytoma (HP:0009592)1.97893199
60Mitral valve prolapse (HP:0001634)1.97527378
61Impaired social interactions (HP:0000735)1.96912659
62Abnormal social behavior (HP:0012433)1.96912659
63Right ventricular cardiomyopathy (HP:0011663)1.94128948
64Arnold-Chiari malformation (HP:0002308)1.94012385
65Mitral regurgitation (HP:0001653)1.93982907
66Spinal rigidity (HP:0003306)1.93977187
67Cerebral inclusion bodies (HP:0100314)1.93931365
68Urinary urgency (HP:0000012)1.93319421
69Epileptic encephalopathy (HP:0200134)1.92874158
70Aortic dissection (HP:0002647)1.92794155
71Mildly elevated creatine phosphokinase (HP:0008180)1.91036395
72Ankle contracture (HP:0006466)1.90756270
73Aortic aneurysm (HP:0004942)1.90560754
74Pointed chin (HP:0000307)1.90553229
75Depression (HP:0000716)1.90380058
76Buphthalmos (HP:0000557)1.90351192
77Overgrowth (HP:0001548)1.90173257
78Short nail (HP:0001799)1.88322649
79Upper limb amyotrophy (HP:0009129)1.88170774
80Distal upper limb amyotrophy (HP:0007149)1.88170774
81Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.88162412
82Deep venous thrombosis (HP:0002625)1.87976596
83Coronal craniosynostosis (HP:0004440)1.86495070
84Ankyloglossia (HP:0010296)1.86057935
85Cervical subluxation (HP:0003308)1.85616786
86Precocious puberty (HP:0000826)1.85040524
87Neoplasm of the heart (HP:0100544)1.84934388
88Neurofibrillary tangles (HP:0002185)1.84406161
89Postural instability (HP:0002172)1.83447818
90Increased connective tissue (HP:0009025)1.80785036
91Poor eye contact (HP:0000817)1.80643489
92Hyperextensible skin (HP:0000974)1.80432529
93Patellar dislocation (HP:0002999)1.79796764
94Atonic seizures (HP:0010819)1.79788132
95Torticollis (HP:0000473)1.79657769
96Agitation (HP:0000713)1.77820289
97Overriding aorta (HP:0002623)1.77558389
98Abnormality of the diencephalon (HP:0010662)1.73746397
99Amyotrophic lateral sclerosis (HP:0007354)1.73411218
100Aneurysm (HP:0002617)1.73030641
101Absence seizures (HP:0002121)1.71906053
102Sacral dimple (HP:0000960)1.71243387
103Genu recurvatum (HP:0002816)1.70844002
104Hypsarrhythmia (HP:0002521)1.70563409
105Osteolytic defects of the phalanges of the hand (HP:0009771)1.70463095
106Osteolytic defects of the hand bones (HP:0009699)1.70463095
107Obstructive sleep apnea (HP:0002870)1.70415402
108Intention tremor (HP:0002080)1.70363634
109Type 1 muscle fiber predominance (HP:0003803)1.70132407
110Thin bony cortex (HP:0002753)1.69123647
111Disproportionate tall stature (HP:0001519)1.68475368
112Sparse lateral eyebrow (HP:0005338)1.68357431
113Germ cell neoplasia (HP:0100728)1.68265524
114Papilledema (HP:0001085)1.68168981
115Broad metatarsal (HP:0001783)1.68121134
116Broad-based gait (HP:0002136)1.68021013
117EEG with generalized epileptiform discharges (HP:0011198)1.67641671
118Narrow palate (HP:0000189)1.67093770
119Bowel diverticulosis (HP:0005222)1.66789252
120Enlarged penis (HP:0000040)1.65964512
121Increased variability in muscle fiber diameter (HP:0003557)1.65917027
122Amblyopia (HP:0000646)1.65875890
123Spastic gait (HP:0002064)1.65527098
124Flat cornea (HP:0007720)1.64823039
125Generalized tonic-clonic seizures (HP:0002069)1.64767630
126Cutaneous finger syndactyly (HP:0010554)1.64763804
127Lower limb muscle weakness (HP:0007340)1.64754736
128Joint laxity (HP:0001388)1.64616651
129Abnormality of the phalanges of the hallux (HP:0010057)1.64209831
130Mitral stenosis (HP:0001718)1.64148347
131Dysmetria (HP:0001310)1.63786825
132Epileptiform EEG discharges (HP:0011182)1.62261887
133Wide anterior fontanel (HP:0000260)1.62202583
134Hammertoe (HP:0001765)1.61819344
135Natal tooth (HP:0000695)1.61449084
136Ventricular fibrillation (HP:0001663)1.60858805
137Abnormality of dentin (HP:0010299)1.60270922
138Hyporeflexia of lower limbs (HP:0002600)1.59772072
139Distal lower limb muscle weakness (HP:0009053)1.59546952
140Microglossia (HP:0000171)1.59094224
141Abnormal ossification of hand bones (HP:0005921)1.59084994
142Obsessive-compulsive behavior (HP:0000722)1.58850946
143Morphological abnormality of the pyramidal tract (HP:0002062)1.58722656
144Subacute progressive viral hepatitis (HP:0006572)1.58557536
145Hyperthyroidism (HP:0000836)1.57339713
146Truncal ataxia (HP:0002078)1.56583998
147Difficulty running (HP:0009046)1.55576323
148Fibroma (HP:0010614)1.55537403
149Relative macrocephaly (HP:0004482)1.55377934
150Spinal cord compression (HP:0002176)1.55236399
151Absent speech (HP:0001344)1.55035899
152Heterotopia (HP:0002282)1.55010604
153Hemiplegia (HP:0002301)1.54692245
154Bladder diverticulum (HP:0000015)1.54395653
155Abnormality of the Achilles tendon (HP:0005109)1.54040451
156Intellectual disability, profound (HP:0002187)1.53943859
157Bundle branch block (HP:0011710)1.53800714
158Back pain (HP:0003418)1.53545438
159Gaze-evoked nystagmus (HP:0000640)1.53522148
160Febrile seizures (HP:0002373)1.53420542
161Blue sclerae (HP:0000592)1.53385375
162Long eyelashes (HP:0000527)1.52266008
163Sudden death (HP:0001699)1.52112211
164Postural tremor (HP:0002174)1.52034754
165Impaired vibratory sensation (HP:0002495)1.51968240
166Hand muscle atrophy (HP:0009130)1.50740854
167Exostoses (HP:0100777)1.50603676
168Tracheomalacia (HP:0002779)1.50382911
169Tibial bowing (HP:0002982)1.49793114
170Bell-shaped thorax (HP:0001591)1.49417595
171Absent frontal sinuses (HP:0002688)1.49374514
172Achilles tendon contracture (HP:0001771)1.49104701
173Biconcave vertebral bodies (HP:0004586)1.48891232
174Long palpebral fissure (HP:0000637)1.48179416

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.90394298
2MAP3K92.87884633
3NTRK32.64810106
4EEF2K2.62142333
5LATS22.43532940
6MAP3K42.39203937
7MINK12.14448990
8PAK62.13297201
9TYRO32.03596483
10STK382.01455667
11PRKD31.93001802
12EPHA41.90335617
13NTRK11.87748011
14ICK1.79521100
15DAPK21.79179701
16NTRK21.78766262
17EPHA21.75504905
18PDGFRA1.73556227
19LATS11.70658057
20KSR11.70238422
21SMG11.69216189
22TRIB31.64850837
23MST1R1.64313941
24PHKG21.59217253
25PHKG11.59217253
26RIPK11.58707444
27FGFR41.56742018
28KSR21.51616954
29MAP2K41.51032473
30CAMK1G1.49217367
31MET1.46499965
32FGFR21.44708562
33EPHB21.42966053
34LMTK21.39786283
35TESK11.37269277
36SIK11.35702012
37CAMKK11.33680528
38DDR21.33415644
39PAK31.28939796
40PKN21.27260598
41RET1.25746970
42MAP3K21.22529347
43UHMK11.16540911
44AKT31.13948238
45STK111.09461283
46CDK51.04063644
47MAP2K71.03301951
48PNCK1.02545213
49BRD41.01252420
50FER1.00439019
51MAPK131.00142450
52CAMK1D0.99880733
53CASK0.97850852
54CDK120.94210403
55ALK0.93434924
56SGK4940.85919866
57SGK2230.85919866
58DMPK0.85464779
59NEK10.85154246
60SGK30.84666744
61ERBB20.83992492
62PTK20.83929615
63CSNK1G20.83344526
64TAOK10.81102906
65SCYL20.80918632
66NEK60.79608968
67PDGFRB0.79500022
68SIK20.78931010
69ERN10.78895232
70MTOR0.76320523
71PRKCG0.76141632
72MARK20.75444068
73FGFR10.74516400
74SGK20.73957924
75PRKCH0.73597810
76BMX0.71730220
77CDK140.70594761
78PDPK10.70225536
79WNK10.69497304
80PRKD20.69056318
81WNK30.67018863
82CDK150.65712743
83CDC42BPA0.65413818
84PRKCZ0.64730626
85CDK180.64364017
86PLK20.61974676
87ERBB30.61197479
88NEK90.60502816
89MAP3K70.60388498
90CAMK2B0.59668335
91CSNK1A1L0.58568583
92PAK40.57261916
93SGK10.55842003
94PTK60.55597326
95TTN0.55177378
96ROCK20.54747143
97PRKAA10.54133142
98CAMK2A0.53752003
99CDK11A0.52980186
100DYRK20.52823635
101RPS6KA30.52294779
102ARAF0.52071318
103MAPK100.50145634
104* ROCK10.49924448
105ERBB40.49506015
106PAK20.49106744
107PRKD10.48101414
108MAP3K100.48083743
109DYRK1A0.46048761
110PIK3CA0.45847184
111CDK70.45549827
112MAP3K60.45204292
113CSNK1E0.45185567
114IRAK30.45067742
115RPS6KA20.44264049
116DYRK1B0.44252892
117CSNK1D0.44188362
118CAMK2G0.42979572
119RPS6KL10.42723011
120RPS6KC10.42723011
121CSNK1G10.42592429
122EPHB10.42335256
123CAMK10.41223782
124FGFR30.40843605
125PRPF4B0.40672170
126CAMK40.40581294
127RPS6KB10.39357365
128MAP2K10.39262093
129GSK3B0.39077739
130MAPK80.38562701
131RPS6KB20.38527411
132MOS0.38143703
133BRAF0.37440460

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.25274935
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79533901
3Nicotine addiction_Homo sapiens_hsa050331.75400334
4Synaptic vesicle cycle_Homo sapiens_hsa047211.70718856
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64258971
6GABAergic synapse_Homo sapiens_hsa047271.63183011
7Axon guidance_Homo sapiens_hsa043601.60014989
8ECM-receptor interaction_Homo sapiens_hsa045121.58385280
9Circadian entrainment_Homo sapiens_hsa047131.56634506
10Long-term potentiation_Homo sapiens_hsa047201.55889711
11Glutamatergic synapse_Homo sapiens_hsa047241.54670609
12Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.46102135
13Olfactory transduction_Homo sapiens_hsa047401.44320321
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44050973
15Dopaminergic synapse_Homo sapiens_hsa047281.43342136
16Arginine biosynthesis_Homo sapiens_hsa002201.42419143
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42361497
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41742745
19Insulin secretion_Homo sapiens_hsa049111.40205284
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39004545
21Type II diabetes mellitus_Homo sapiens_hsa049301.38521148
22Chronic myeloid leukemia_Homo sapiens_hsa052201.37337788
23Thyroid cancer_Homo sapiens_hsa052161.35514270
24Cholinergic synapse_Homo sapiens_hsa047251.35097997
25Amphetamine addiction_Homo sapiens_hsa050311.32844538
26Glioma_Homo sapiens_hsa052141.32005370
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30545934
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29624391
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25367967
30Endometrial cancer_Homo sapiens_hsa052131.24162385
31Butanoate metabolism_Homo sapiens_hsa006501.23421488
32Salivary secretion_Homo sapiens_hsa049701.23247088
33Bile secretion_Homo sapiens_hsa049761.22565392
34Morphine addiction_Homo sapiens_hsa050321.21776782
35Notch signaling pathway_Homo sapiens_hsa043301.21337086
36Gastric acid secretion_Homo sapiens_hsa049711.20113437
37Gap junction_Homo sapiens_hsa045401.19766210
38Melanogenesis_Homo sapiens_hsa049161.18907395
39Basal cell carcinoma_Homo sapiens_hsa052171.15356690
40Estrogen signaling pathway_Homo sapiens_hsa049151.15123673
41Dorso-ventral axis formation_Homo sapiens_hsa043201.13529223
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09843703
43Renin secretion_Homo sapiens_hsa049241.08651675
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.08012229
45Oxytocin signaling pathway_Homo sapiens_hsa049211.07947485
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06407540
47GnRH signaling pathway_Homo sapiens_hsa049121.05319930
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05000937
49ErbB signaling pathway_Homo sapiens_hsa040121.04353329
50Cocaine addiction_Homo sapiens_hsa050301.03969257
51mTOR signaling pathway_Homo sapiens_hsa041501.03680318
52Long-term depression_Homo sapiens_hsa047301.01917431
53Hippo signaling pathway_Homo sapiens_hsa043901.01625822
54Inositol phosphate metabolism_Homo sapiens_hsa005621.00702369
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00203156
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99935178
57Hedgehog signaling pathway_Homo sapiens_hsa043400.98655516
58Prostate cancer_Homo sapiens_hsa052150.97880656
59Dilated cardiomyopathy_Homo sapiens_hsa054140.96047120
60Bladder cancer_Homo sapiens_hsa052190.93939074
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93786668
62Pancreatic cancer_Homo sapiens_hsa052120.93774041
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92522406
64Vitamin B6 metabolism_Homo sapiens_hsa007500.89693999
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88442086
66cAMP signaling pathway_Homo sapiens_hsa040240.88123441
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87895223
68Amoebiasis_Homo sapiens_hsa051460.86475641
69Wnt signaling pathway_Homo sapiens_hsa043100.86403155
70Fatty acid biosynthesis_Homo sapiens_hsa000610.85807338
71Adherens junction_Homo sapiens_hsa045200.84963359
72Glucagon signaling pathway_Homo sapiens_hsa049220.84607608
73Taste transduction_Homo sapiens_hsa047420.84511961
74Insulin signaling pathway_Homo sapiens_hsa049100.83944236
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82953133
76Lysine degradation_Homo sapiens_hsa003100.82751297
77Protein digestion and absorption_Homo sapiens_hsa049740.82673342
78Fatty acid metabolism_Homo sapiens_hsa012120.80140125
79Renal cell carcinoma_Homo sapiens_hsa052110.80140092
80Colorectal cancer_Homo sapiens_hsa052100.79996538
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.79526974
82Small cell lung cancer_Homo sapiens_hsa052220.79298401
83Tight junction_Homo sapiens_hsa045300.78307323
84Prolactin signaling pathway_Homo sapiens_hsa049170.77977149
85* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76990592
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.76935798
87AMPK signaling pathway_Homo sapiens_hsa041520.76768145
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76428737
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76325996
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75773920
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74532790
92Prion diseases_Homo sapiens_hsa050200.73744705
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73705722
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73185891
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72400312
96Acute myeloid leukemia_Homo sapiens_hsa052210.71143345
97Thyroid hormone synthesis_Homo sapiens_hsa049180.70119747
98Choline metabolism in cancer_Homo sapiens_hsa052310.69114350
99Proteoglycans in cancer_Homo sapiens_hsa052050.68902771
100Calcium signaling pathway_Homo sapiens_hsa040200.68717471
101Serotonergic synapse_Homo sapiens_hsa047260.67182831
102Insulin resistance_Homo sapiens_hsa049310.66704967
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.66384648
104Oocyte meiosis_Homo sapiens_hsa041140.66362221
105* Focal adhesion_Homo sapiens_hsa045100.66345144
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63148455
107PPAR signaling pathway_Homo sapiens_hsa033200.62267374
108Endocytosis_Homo sapiens_hsa041440.61568417
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61177914
110Fatty acid degradation_Homo sapiens_hsa000710.60558714
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.60498264
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59678378
113Rap1 signaling pathway_Homo sapiens_hsa040150.57389922
114Non-small cell lung cancer_Homo sapiens_hsa052230.57210114
115Tryptophan metabolism_Homo sapiens_hsa003800.57120307
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.55880953
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53648354
118VEGF signaling pathway_Homo sapiens_hsa043700.50570979
119Melanoma_Homo sapiens_hsa052180.48940567
120MAPK signaling pathway_Homo sapiens_hsa040100.48646564
121MicroRNAs in cancer_Homo sapiens_hsa052060.47201884
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46522541

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »