ARHGAP36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to ethanol (GO:0048149)8.07484285
2phenol-containing compound catabolic process (GO:0019336)7.55515465
3neurofilament cytoskeleton organization (GO:0060052)6.67142719
4enteric nervous system development (GO:0048484)5.76191375
5sympathetic nervous system development (GO:0048485)5.75580989
6cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.71337735
7skeletal muscle contraction (GO:0003009)5.69555498
8norepinephrine metabolic process (GO:0042415)5.66708509
9glucocorticoid biosynthetic process (GO:0006704)5.64054995
10cell migration in hindbrain (GO:0021535)5.50717207
11maternal behavior (GO:0042711)5.50280362
12catecholamine biosynthetic process (GO:0042423)5.50072682
13catechol-containing compound biosynthetic process (GO:0009713)5.50072682
14behavioral response to nicotine (GO:0035095)5.45398616
15actin-myosin filament sliding (GO:0033275)5.27580919
16muscle filament sliding (GO:0030049)5.27580919
17COPI coating of Golgi vesicle (GO:0048205)5.23823419
18Golgi transport vesicle coating (GO:0048200)5.23823419
19C21-steroid hormone biosynthetic process (GO:0006700)5.10125122
20cardiac ventricle formation (GO:0003211)5.05046620
21cartilage morphogenesis (GO:0060536)5.04695183
22parental behavior (GO:0060746)4.90925381
23synaptic transmission, cholinergic (GO:0007271)4.78160943
24cardiac chamber formation (GO:0003207)4.71034923
25response to inactivity (GO:0014854)4.70774261
26glucocorticoid metabolic process (GO:0008211)4.69530422
27response to pain (GO:0048265)4.68011714
28positive regulation of glomerulus development (GO:0090193)4.61418812
29protein maturation by protein folding (GO:0022417)4.55667370
30neuromuscular process controlling posture (GO:0050884)4.52578586
31response to insecticide (GO:0017085)4.52137797
32neurotransmitter secretion (GO:0007269)4.44692839
33sarcoplasmic reticulum calcium ion transport (GO:0070296)4.43878528
34response to follicle-stimulating hormone (GO:0032354)4.43620405
35cellular response to antibiotic (GO:0071236)4.33276324
36actin-mediated cell contraction (GO:0070252)4.29275824
37positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.26808181
38androgen biosynthetic process (GO:0006702)4.19144742
39respiratory system process (GO:0003016)4.15809324
40dopamine metabolic process (GO:0042417)4.12216259
41synaptic vesicle maturation (GO:0016188)4.12029192
42regulation of short-term neuronal synaptic plasticity (GO:0048172)4.10959917
43regulation of synaptic vesicle exocytosis (GO:2000300)4.10659606
44regulation of secondary heart field cardioblast proliferation (GO:0003266)4.08835194
45regulation of cardioblast proliferation (GO:0003264)4.08835194
46negative regulation of cytosolic calcium ion concentration (GO:0051481)4.07729732
47negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.07014961
48estrogen biosynthetic process (GO:0006703)4.02696387
49response to pheromone (GO:0019236)3.99739309
50coronary vasculature morphogenesis (GO:0060977)3.99637257
51negative regulation of potassium ion transmembrane transport (GO:1901380)3.98173540
52synaptic vesicle exocytosis (GO:0016079)3.91455845
53insulin secretion (GO:0030073)3.85641151
54positive regulation of hormone biosynthetic process (GO:0046886)3.81962530
55endocrine pancreas development (GO:0031018)3.81148477
56positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.81036343
57neuronal action potential propagation (GO:0019227)3.80569692
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.79269236
59activation of protein kinase A activity (GO:0034199)3.76704519
60parturition (GO:0007567)3.75570777
61regulation of skeletal muscle contraction (GO:0014819)3.66811130
62maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.65361781
63peripheral nervous system neuron development (GO:0048935)3.59936864
64progesterone metabolic process (GO:0042448)3.56934318
65regulation of type B pancreatic cell apoptotic process (GO:2000674)3.54026777
66ganglion development (GO:0061548)3.50662515
67neurotransmitter transport (GO:0006836)3.50486897
68pyrimidine nucleobase catabolic process (GO:0006208)3.50189597
69dopaminergic neuron differentiation (GO:0071542)3.50068955
70negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.48706719
71negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.45582829
72axonal fasciculation (GO:0007413)3.45026495
73axon cargo transport (GO:0008088)3.44963836
74regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.44508230
75energy coupled proton transport, down electrochemical gradient (GO:0015985)3.43559893
76ATP synthesis coupled proton transport (GO:0015986)3.43559893
77regulation of synaptic vesicle transport (GO:1902803)3.42487459
78fear response (GO:0042596)3.42462853
79exploration behavior (GO:0035640)3.42161704
80retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.41216101
81protein localization to synapse (GO:0035418)3.40877439
82regulation of vesicle fusion (GO:0031338)3.40630531
83cellular response to toxic substance (GO:0097237)3.38705015
84striated muscle contraction (GO:0006941)3.38369203
85regulation of insulin secretion (GO:0050796)3.36663600
86response to parathyroid hormone (GO:0071107)3.35845994
87cellular response to glucagon stimulus (GO:0071377)3.35657551
88neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.32994782
89mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.32377912
90positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.31950159
91catecholamine transport (GO:0051937)3.31471168
92peptide hormone processing (GO:0016486)3.30984828
93neuromuscular synaptic transmission (GO:0007274)3.30328222
94cellular response to gonadotropin stimulus (GO:0071371)3.29990728
95nitric oxide mediated signal transduction (GO:0007263)3.29630292
96ATP hydrolysis coupled proton transport (GO:0015991)3.28674181
97energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.28674181
98regulation of cardiac muscle cell apoptotic process (GO:0010665)3.27841735
99sarcomere organization (GO:0045214)3.27080062
100regulation of neurotransmitter levels (GO:0001505)3.25489139
101mating behavior (GO:0007617)3.25130340
102regulation of synapse structural plasticity (GO:0051823)3.24060223
103signal release (GO:0023061)3.22926304
104cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.21207258
105regulation of respiratory gaseous exchange (GO:0043576)3.20633441
106dopamine biosynthetic process (GO:0042416)3.20467734
107cellular response to epinephrine stimulus (GO:0071872)3.19724971
108calcium-mediated signaling using intracellular calcium source (GO:0035584)3.19118518
109actin filament-based movement (GO:0030048)3.18387404
110positive regulation of insulin secretion (GO:0032024)3.17250104
111negative regulation of heart rate (GO:0010459)3.17142959
112glutamate secretion (GO:0014047)3.16673704
113response to amphetamine (GO:0001975)3.14766626
114protein retention in ER lumen (GO:0006621)3.12363964
115negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.11138111
116suckling behavior (GO:0001967)3.08255933
117melanosome transport (GO:0032402)3.08138729
118regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.07968010
119regulation of peptide hormone secretion (GO:0090276)3.06534192
120C21-steroid hormone metabolic process (GO:0008207)3.05974171
121phenol-containing compound biosynthetic process (GO:0046189)3.05442025
122regulation of amyloid precursor protein catabolic process (GO:1902991)3.05073585
123cell communication by electrical coupling (GO:0010644)3.04214868
124negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.04042872
125detection of calcium ion (GO:0005513)3.04005447
126multi-organism reproductive behavior (GO:0044705)3.03969200
127regulation of peptide secretion (GO:0002791)3.03451050
128regulation of microtubule-based movement (GO:0060632)3.01931488
129establishment of melanosome localization (GO:0032401)3.01711432
130positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01341343
131glandular epithelial cell differentiation (GO:0002067)3.01334911
132positive regulation of myotube differentiation (GO:0010831)2.98615100
133cell migration involved in heart development (GO:0060973)2.98429451
134regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.96777855
135cellular sodium ion homeostasis (GO:0006883)2.95915800
136regulation of oxidative phosphorylation (GO:0002082)2.94876826
137ER overload response (GO:0006983)2.94664360
138cellular response to catecholamine stimulus (GO:0071870)2.94411609
139cellular response to monoamine stimulus (GO:0071868)2.94411609
140vesicle transport along microtubule (GO:0047496)2.92401295
141pigment granule transport (GO:0051904)2.91839439
142innervation (GO:0060384)2.91311036
143respiratory electron transport chain (GO:0022904)2.90941133
144positive regulation of hormone metabolic process (GO:0032352)2.89696327
145negative regulation of catecholamine secretion (GO:0033604)2.89470659
146synaptic vesicle docking involved in exocytosis (GO:0016081)2.88389093
147positive regulation of vesicle fusion (GO:0031340)2.87758540
148electron transport chain (GO:0022900)2.87692582
149organelle transport along microtubule (GO:0072384)2.87452751
150Leydig cell differentiation (GO:0033327)2.87378014
151positive regulation of potassium ion transport (GO:0043268)2.86485269
152establishment of pigment granule localization (GO:0051905)2.86445169
153positive regulation of exocytosis (GO:0045921)2.85990138
154response to corticosterone (GO:0051412)2.85735663
155positive regulation of potassium ion transmembrane transport (GO:1901381)2.85393255
156visual learning (GO:0008542)2.85390181
157regulation of calcium ion-dependent exocytosis (GO:0017158)2.85299048
158peptide hormone secretion (GO:0030072)2.85296927
159regulation of membrane repolarization (GO:0060306)2.84157439
160multicellular organismal reproductive behavior (GO:0033057)2.82863139
161negative regulation of microtubule polymerization (GO:0031115)2.82632755
162skeletal muscle organ development (GO:0060538)2.81662006
163positive regulation of renal sodium excretion (GO:0035815)2.81061284
164positive regulation of synaptic transmission, GABAergic (GO:0032230)2.80990759
165neuron cell-cell adhesion (GO:0007158)2.79817378
166presynaptic membrane assembly (GO:0097105)2.79481648
167reproductive behavior (GO:0019098)2.79074172
168regulation of glomerulus development (GO:0090192)2.77636929
169adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.77416962
170vesicle coating (GO:0006901)2.76326289
171cerebellar Purkinje cell differentiation (GO:0021702)2.73962303
172cerebellar Purkinje cell layer development (GO:0021680)2.73434324
173peptide secretion (GO:0002790)2.73137946
174negative regulation of insulin secretion (GO:0046676)2.72377869
175microtubule-based transport (GO:0010970)2.71132903
176negative regulation of calcium ion transport into cytosol (GO:0010523)2.71007561
177proline transport (GO:0015824)2.69988836
178intermediate filament organization (GO:0045109)2.69449058
179eating behavior (GO:0042755)2.68791468
180locomotory exploration behavior (GO:0035641)2.66591410
181regulation of hormone secretion (GO:0046883)2.66084350
182positive regulation of peptide hormone secretion (GO:0090277)2.64204489
183positive regulation of peptide secretion (GO:0002793)2.63514495
184positive regulation of amino acid transport (GO:0051957)2.62941547
185regulation of exocytosis (GO:0017157)2.62674146
186calcium ion-dependent exocytosis (GO:0017156)2.62318247
187melanosome localization (GO:0032400)2.61520408
188negative regulation of norepinephrine secretion (GO:0010700)2.60792680
189opioid receptor signaling pathway (GO:0038003)2.60656180
190transferrin transport (GO:0033572)2.59999745
191regulation of Golgi to plasma membrane protein transport (GO:0042996)2.59505402

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.92433603
2CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.34511525
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.31535622
4REST_21632747_ChIP-Seq_MESCs_Mouse3.07802404
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83940171
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.77465677
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71535607
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.68927224
9GBX2_23144817_ChIP-Seq_PC3_Human2.68877030
10REST_18959480_ChIP-ChIP_MESCs_Mouse2.64344547
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58418004
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.48535907
13ZNF274_21170338_ChIP-Seq_K562_Hela2.47325646
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40660335
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.39579968
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38313606
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36117134
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.28656643
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.26726271
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22938638
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17742673
22NR3C1_23031785_ChIP-Seq_PC12_Mouse2.14989873
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.14231925
24RNF2_18974828_ChIP-Seq_MESCs_Mouse2.14231925
25TAF15_26573619_Chip-Seq_HEK293_Human2.05083390
26ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.02938168
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02838115
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93367180
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.92893701
30ZNF263_19887448_ChIP-Seq_K562_Human1.85175662
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84571758
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.84089498
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.81726537
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.78714156
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.77387863
36IGF1R_20145208_ChIP-Seq_DFB_Human1.76614559
37* RNF2_27304074_Chip-Seq_ESCs_Mouse1.72143978
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.71977661
39GATA1_26923725_Chip-Seq_HPCs_Mouse1.60438492
40CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.60245351
41OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.59998624
42DROSHA_22980978_ChIP-Seq_HELA_Human1.58855419
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54167032
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50604619
45SMAD4_21799915_ChIP-Seq_A2780_Human1.48532676
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40876892
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.39070772
48REST_19997604_ChIP-ChIP_NEURONS_Mouse1.38967972
49RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38733124
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32364736
51DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28004109
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27816141
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.27235881
54FUS_26573619_Chip-Seq_HEK293_Human1.27041849
55ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25241494
56SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25135778
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.24745084
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21467938
59CTCF_27219007_Chip-Seq_Bcells_Human1.20996199
60SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15763289
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15145666
62AR_25329375_ChIP-Seq_VCAP_Human1.13612701
63VDR_22108803_ChIP-Seq_LS180_Human1.12504146
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12399115
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.12301558
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10262217
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.09868326
68TET1_21490601_ChIP-Seq_MESCs_Mouse1.09832419
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09090019
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08774877
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.07590785
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07578726
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06459369
74P300_19829295_ChIP-Seq_ESCs_Human1.06324812
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05888401
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05223728
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04003841
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03337142
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02876543
80* RNF2_27304074_Chip-Seq_NSC_Mouse1.02331608
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01618838
82SMAD3_21741376_ChIP-Seq_ESCs_Human1.00957102
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.00874086
84BCAT_22108803_ChIP-Seq_LS180_Human1.00313382
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99779320
86STAT3_23295773_ChIP-Seq_U87_Human0.99453602
87CBX2_27304074_Chip-Seq_ESCs_Mouse0.98614115
88TAL1_26923725_Chip-Seq_HPCs_Mouse0.98229513
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98151781
90SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.98115919
91TP53_20018659_ChIP-ChIP_R1E_Mouse0.96602841
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95180964
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94601162
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93921075
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93915987
96EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92887570
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92775983
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.92544871
99RUNX2_22187159_ChIP-Seq_PCA_Human0.92455463
100AR_19668381_ChIP-Seq_PC3_Human0.92289122
101YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91864228
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91492630
103KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91480398
104NANOG_18555785_Chip-Seq_ESCs_Mouse0.90686161
105CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88179131
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87545598
107FLI1_21867929_ChIP-Seq_TH2_Mouse0.87476718
108* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86699945
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86163977
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85689863
111ISL1_27105846_Chip-Seq_CPCs_Mouse0.85638046
112PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84415284
113WT1_19549856_ChIP-ChIP_CCG9911_Human0.84120579
114MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.83534460
115* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81617165
116* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80233920
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79483521
118E2F1_17053090_ChIP-ChIP_MCF-7_Human0.79432665
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79276391
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.78794662
121POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78710118
122TCF4_23295773_ChIP-Seq_U87_Human0.76535886
123ELK4_26923725_Chip-Seq_MESODERM_Mouse0.76455052
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76283546
125WT1_25993318_ChIP-Seq_PODOCYTE_Human0.75565370
126RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.75072011
127TP53_22573176_ChIP-Seq_HFKS_Human0.74451930
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.74262395
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.74026026
130JUN_21703547_ChIP-Seq_K562_Human0.73856661

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting5.05452716
2MP0006276_abnormal_autonomic_nervous3.43996857
3MP0003283_abnormal_digestive_organ3.09594529
4MP0004270_analgesia3.05918862
5MP0005645_abnormal_hypothalamus_physiol2.77430746
6MP0004859_abnormal_synaptic_plasticity2.74866518
7MP0002909_abnormal_adrenal_gland2.62406433
8MP0004142_abnormal_muscle_tone2.61958894
9MP0003635_abnormal_synaptic_transmissio2.53284940
10MP0002734_abnormal_mechanical_nocicepti2.52060230
11MP0008438_abnormal_cutaneous_collagen2.50683245
12MP0003880_abnormal_central_pattern2.50183303
13MP0003123_paternal_imprinting2.43128935
14MP0002733_abnormal_thermal_nociception2.35637996
15MP0002735_abnormal_chemical_nociception2.31421616
16MP0004043_abnormal_pH_regulation2.25848644
17MP0009780_abnormal_chondrocyte_physiolo2.25836355
18MP0001968_abnormal_touch/_nociception2.25354017
19MP0003787_abnormal_imprinting2.21022106
20MP0002184_abnormal_innervation2.20479195
21MP0002693_abnormal_pancreas_physiology2.19290007
22MP0002837_dystrophic_cardiac_calcinosis2.17252346
23MP0002272_abnormal_nervous_system2.13138016
24MP0010386_abnormal_urinary_bladder2.07779218
25MP0001970_abnormal_pain_threshold2.07733717
26MP0000013_abnormal_adipose_tissue2.06047947
27MP0000955_abnormal_spinal_cord2.05799379
28MP0002638_abnormal_pupillary_reflex2.04721705
29MP0001944_abnormal_pancreas_morphology2.00815712
30MP0005646_abnormal_pituitary_gland1.98674242
31MP0003121_genomic_imprinting1.96391970
32MP0002064_seizures1.93199250
33MP0009745_abnormal_behavioral_response1.91567449
34MP0006072_abnormal_retinal_apoptosis1.87739526
35MP0009046_muscle_twitch1.87349480
36MP0005423_abnormal_somatic_nervous1.84755443
37MP0000749_muscle_degeneration1.81725374
38MP0002736_abnormal_nociception_after1.79214497
39MP0002063_abnormal_learning/memory/cond1.77068627
40MP0001986_abnormal_taste_sensitivity1.76219593
41MP0002877_abnormal_melanocyte_morpholog1.69618360
42MP0002572_abnormal_emotion/affect_behav1.69054545
43MP0005379_endocrine/exocrine_gland_phen1.61737040
44MP0005187_abnormal_penis_morphology1.61467782
45MP0001501_abnormal_sleep_pattern1.53832979
46MP0010368_abnormal_lymphatic_system1.50664997
47MP0001529_abnormal_vocalization1.46906854
48MP0003329_amyloid_beta_deposits1.45897289
49MP0002067_abnormal_sensory_capabilities1.44641604
50MP0003195_calcinosis1.44378660
51MP0003567_abnormal_fetal_cardiomyocyte1.41573493
52MP0000750_abnormal_muscle_regeneration1.40817778
53MP0000751_myopathy1.40446656
54MP0004858_abnormal_nervous_system1.40355702
55MP0002106_abnormal_muscle_physiology1.38018553
56MP0002078_abnormal_glucose_homeostasis1.37527464
57MP0001440_abnormal_grooming_behavior1.36097348
58MP0004264_abnormal_extraembryonic_tissu1.35475119
59MP0001502_abnormal_circadian_rhythm1.34647219
60MP0000678_abnormal_parathyroid_gland1.34443664
61MP0000759_abnormal_skeletal_muscle1.34155869
62MP0002557_abnormal_social/conspecific_i1.31943894
63MP0004811_abnormal_neuron_physiology1.30766894
64MP0000462_abnormal_digestive_system1.23836197
65MP0002882_abnormal_neuron_morphology1.22025833
66MP0008877_abnormal_DNA_methylation1.21115940
67MP0002332_abnormal_exercise_endurance1.20571173
68MP0005275_abnormal_skin_tensile1.19786695
69MP0004145_abnormal_muscle_electrophysio1.19612258
70MP0004924_abnormal_behavior1.18542778
71MP0005386_behavior/neurological_phenoty1.18542778
72MP0001984_abnormal_olfaction1.18493320
73MP0005369_muscle_phenotype1.18397729
74MP0000631_abnormal_neuroendocrine_gland1.15685261
75MP0002751_abnormal_autonomic_nervous1.15342103
76MP0004087_abnormal_muscle_fiber1.13726334
77MP0005535_abnormal_body_temperature1.12817158
78MP0002269_muscular_atrophy1.12495190
79MP0005220_abnormal_exocrine_pancreas1.11681475
80MP0002009_preneoplasia1.09759423
81MP0002229_neurodegeneration1.07274854
82MP0001486_abnormal_startle_reflex1.07139889
83MP0002066_abnormal_motor_capabilities/c1.04303667
84MP0003183_abnormal_peptide_metabolism1.03481604
85MP0003959_abnormal_lean_body0.99631497
86MP0003953_abnormal_hormone_level0.95944141
87MP0008995_early_reproductive_senescence0.95803891
88MP0000747_muscle_weakness0.95639002
89MP0005409_darkened_coat_color0.93485322
90MP0008569_lethality_at_weaning0.93427963
91MP0000538_abnormal_urinary_bladder0.92337940
92MP0002822_catalepsy0.92306937
93MP0001348_abnormal_lacrimal_gland0.91704397
94MP0005620_abnormal_muscle_contractility0.91038689
95MP0002127_abnormal_cardiovascular_syste0.90528330
96MP0002163_abnormal_gland_morphology0.90224918
97MP0002876_abnormal_thyroid_physiology0.89809626
98MP0001299_abnormal_eye_distance/0.88049049
99MP0000778_abnormal_nervous_system0.87862875
100MP0000003_abnormal_adipose_tissue0.83218433
101MP0008961_abnormal_basal_metabolism0.82473630
102MP0003942_abnormal_urinary_system0.82457774
103MP0001188_hyperpigmentation0.82138074
104MP0002108_abnormal_muscle_morphology0.81557493
105MP0002069_abnormal_eating/drinking_beha0.81275108
106MP0001270_distended_abdomen0.80622074
107MP0004134_abnormal_chest_morphology0.80569386
108MP0002752_abnormal_somatic_nervous0.79973344
109MP0003633_abnormal_nervous_system0.79781637
110MP0005253_abnormal_eye_physiology0.78735051
111MP0005448_abnormal_energy_balance0.78235003
112MP0002249_abnormal_larynx_morphology0.77615187
113MP0000639_abnormal_adrenal_gland0.72682861
114MP0001765_abnormal_ion_homeostasis0.72362225
115MP0004085_abnormal_heartbeat0.69799647
116MP0004484_altered_response_of0.69506968
117MP0004036_abnormal_muscle_relaxation0.69379162
118MP0001340_abnormal_eyelid_morphology0.69131502
119MP0000733_abnormal_muscle_development0.69129540
120MP0003634_abnormal_glial_cell0.68769055
121MP0005503_abnormal_tendon_morphology0.68708746
122MP0004233_abnormal_muscle_weight0.68411117
123MP0003879_abnormal_hair_cell0.67725661
124MP0000230_abnormal_systemic_arterial0.65787672
125MP0001905_abnormal_dopamine_level0.64254683
126MP0000534_abnormal_ureter_morphology0.63933758
127MP0003631_nervous_system_phenotype0.63402567
128MP0003937_abnormal_limbs/digits/tail_de0.59551278
129MP0002152_abnormal_brain_morphology0.59344345
130MP0001664_abnormal_digestion0.58081612
131MP0004215_abnormal_myocardial_fiber0.56169649
132MP0003948_abnormal_gas_homeostasis0.53391861
133MP0001943_abnormal_respiration0.53078615
134MP0008872_abnormal_physiological_respon0.53076714
135MP0003941_abnormal_skin_development0.52556892
136MP0002081_perinatal_lethality0.52483165

Predicted human phenotypes

RankGene SetZ-score
1Neonatal hypoglycemia (HP:0001998)7.40033075
2Round ear (HP:0100830)7.35554681
3Ulnar deviation of the wrist (HP:0003049)6.62584509
4Calcaneovalgus deformity (HP:0001848)6.36207694
5Fetal akinesia sequence (HP:0001989)5.62746417
6Deformed tarsal bones (HP:0008119)5.59732333
7Hyperinsulinemic hypoglycemia (HP:0000825)5.36671718
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.36218714
9Absent phalangeal crease (HP:0006109)5.04484325
10Pendular nystagmus (HP:0012043)4.81070980
11Breech presentation (HP:0001623)4.66052547
12Pheochromocytoma (HP:0002666)4.56063962
13Orthostatic hypotension (HP:0001278)4.51438236
14Hypoglycemic seizures (HP:0002173)4.40513374
15Trismus (HP:0000211)4.36950521
16Abnormal finger flexion creases (HP:0006143)4.36621530
17Malignant hyperthermia (HP:0002047)4.13229456
18Myokymia (HP:0002411)4.11080013
19Agitation (HP:0000713)4.02499501
20Abnormality of the calcaneus (HP:0008364)4.02048131
21Neuroendocrine neoplasm (HP:0100634)4.00518940
22Nemaline bodies (HP:0003798)3.94732633
23Hypercortisolism (HP:0001578)3.86131476
24Menstrual irregularities (HP:0000858)3.84350733
25Abnormality of calcium-phosphate metabolism (HP:0100530)3.80783034
26Popliteal pterygium (HP:0009756)3.69540869
27Hypoglycemic coma (HP:0001325)3.66681828
28Symptomatic seizures (HP:0011145)3.66335271
29Failure to thrive in infancy (HP:0001531)3.65955690
30Ketoacidosis (HP:0001993)3.65069563
31Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.61622079
32Visual hallucinations (HP:0002367)3.61602718
33Aplasia of the musculature (HP:0100854)3.57747774
34Poor suck (HP:0002033)3.55310234
35Metatarsus adductus (HP:0001840)3.52580255
36Abnormal autonomic nervous system physiology (HP:0012332)3.49281095
37Unilateral renal agenesis (HP:0000122)3.47415752
38Hypothermia (HP:0002045)3.46407789
39Akinesia (HP:0002304)3.32897942
40Supranuclear gaze palsy (HP:0000605)3.32369074
41Muscle fiber inclusion bodies (HP:0100299)3.28106798
42Hyperparathyroidism (HP:0000843)3.22570870
43Symphalangism affecting the phalanges of the hand (HP:0009773)3.11342707
44Chin dimple (HP:0010751)3.11065210
45Hip contracture (HP:0003273)3.09873670
46Atonic seizures (HP:0010819)3.06981682
47Impaired vibration sensation in the lower limbs (HP:0002166)3.06826621
48Neoplasm of the heart (HP:0100544)3.06601321
49Ulnar claw (HP:0001178)3.06555221
50Hyperglycemia (HP:0003074)3.04920169
51Septo-optic dysplasia (HP:0100842)2.98112903
52Oligomenorrhea (HP:0000876)2.93576824
53Growth hormone excess (HP:0000845)2.86017640
54Anxiety (HP:0000739)2.78984817
55Focal seizures (HP:0007359)2.74095877
56Distal arthrogryposis (HP:0005684)2.68525552
57Abnormal pancreas size (HP:0012094)2.65712464
58Type 1 muscle fiber predominance (HP:0003803)2.65646270
59Depression (HP:0000716)2.64542834
60Focal motor seizures (HP:0011153)2.60419923
61Acute necrotizing encephalopathy (HP:0006965)2.58837117
62Abnormality of placental membranes (HP:0011409)2.58077244
63Amniotic constriction ring (HP:0009775)2.58077244
64Abnormal hair whorl (HP:0010721)2.57230302
65Abnormal auditory evoked potentials (HP:0006958)2.53284730
66Insulin-resistant diabetes mellitus (HP:0000831)2.53175207
67Renal salt wasting (HP:0000127)2.52509176
68Absence seizures (HP:0002121)2.52414578
69Abnormal mitochondria in muscle tissue (HP:0008316)2.49325577
70Exercise-induced myalgia (HP:0003738)2.45831479
71Bicornuate uterus (HP:0000813)2.44415685
72Adrenal overactivity (HP:0002717)2.42880784
73EEG with generalized epileptiform discharges (HP:0011198)2.41233938
74Restlessness (HP:0000711)2.41211960
75Cutaneous syndactyly (HP:0012725)2.39560967
76Hypsarrhythmia (HP:0002521)2.39264512
77Septate vagina (HP:0001153)2.38873587
78Polyphagia (HP:0002591)2.38357557
79Progressive cerebellar ataxia (HP:0002073)2.38041795
80Ankle clonus (HP:0011448)2.36181296
81Asymmetry of the thorax (HP:0001555)2.34878282
82Rocker bottom foot (HP:0001838)2.33990726
83Late onset (HP:0003584)2.33356733
84Osteomalacia (HP:0002749)2.32173458
85Epileptiform EEG discharges (HP:0011182)2.31857576
86Ulnar deviation of finger (HP:0009465)2.31293668
87Abnormality of endocrine pancreas physiology (HP:0012093)2.30187497
88Abnormality of the pancreatic islet cells (HP:0006476)2.30187497
89Generalized tonic-clonic seizures (HP:0002069)2.28966796
90Hammertoe (HP:0001765)2.25164143
91Dialeptic seizures (HP:0011146)2.23225261
92Muscle fiber splitting (HP:0003555)2.22622081
93Long clavicles (HP:0000890)2.21796591
94Psychosis (HP:0000709)2.21664875
95Mitochondrial inheritance (HP:0001427)2.21295890
96Limited hip movement (HP:0008800)2.19681451
97Abnormality of pain sensation (HP:0010832)2.17951126
98Impaired pain sensation (HP:0007328)2.17951126
99Sensorimotor neuropathy (HP:0007141)2.17847582
100Hypoventilation (HP:0002791)2.17771056
101Testicular neoplasm (HP:0010788)2.17769402
102Horizontal nystagmus (HP:0000666)2.17730886
103Progressive macrocephaly (HP:0004481)2.15514695
104Abnormal eating behavior (HP:0100738)2.13894079
105Neoplasm of the peripheral nervous system (HP:0100007)2.13739372
106Delayed gross motor development (HP:0002194)2.10500790
107Ketosis (HP:0001946)2.08106045
108Abnormality of the vocal cords (HP:0008777)2.07587367
109Calf muscle hypertrophy (HP:0008981)2.07422108
110Abnormal sex determination (HP:0012244)2.04486169
111Sex reversal (HP:0012245)2.04486169
112Hepatic necrosis (HP:0002605)2.03565818
113Acute encephalopathy (HP:0006846)1.97909377
114Sudden death (HP:0001699)1.92398322
115Limb dystonia (HP:0002451)1.90588910
116Febrile seizures (HP:0002373)1.89969282
117Absent septum pellucidum (HP:0001331)1.89717971
118Aplasia/Hypoplasia of the brainstem (HP:0007362)1.89539449
119Hypoplasia of the brainstem (HP:0002365)1.89539449
120Neoplasm of the adrenal gland (HP:0100631)1.89335091
121Hyporeflexia of lower limbs (HP:0002600)1.87985178
122Emotional lability (HP:0000712)1.87850510
123Truncal ataxia (HP:0002078)1.86340336
124Ventricular fibrillation (HP:0001663)1.85768239
125Amblyopia (HP:0000646)1.84363583
126Hyperthyroidism (HP:0000836)1.84036256
127Exercise-induced muscle cramps (HP:0003710)1.83700726
128Hepatocellular necrosis (HP:0001404)1.82770621
129Abnormality of the calf musculature (HP:0001430)1.82754317
130Aplasia/Hypoplasia involving the musculature (HP:0001460)1.81744047
131Mask-like facies (HP:0000298)1.81360825
132Hypokalemia (HP:0002900)1.80877580
133Action tremor (HP:0002345)1.80658627
134Hyperphosphaturia (HP:0003109)1.80234278
135Nasal speech (HP:0001611)1.79886437
136Generalized hypotonia (HP:0001290)1.79790582
137Muscle hypertrophy of the lower extremities (HP:0008968)1.79747591
138Hypogonadotrophic hypogonadism (HP:0000044)1.78547642
139Epileptic encephalopathy (HP:0200134)1.77988720
140Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.77554982
141Webbed neck (HP:0000465)1.76922938
142Cortical visual impairment (HP:0100704)1.76490006
143Anteriorly placed anus (HP:0001545)1.75883305
144Myotonia (HP:0002486)1.75382261
145Pancreatic islet-cell hyperplasia (HP:0004510)1.74798539
146Dysautonomia (HP:0002459)1.74378032
147Abnormality of the septum pellucidum (HP:0007375)1.74220479
148Adducted thumb (HP:0001181)1.74167887
149Myopathic facies (HP:0002058)1.74166054
150Myelomeningocele (HP:0002475)1.73552914
151Hypotension (HP:0002615)1.73384640
152Exocrine pancreatic insufficiency (HP:0001738)1.73194253
153Gowers sign (HP:0003391)1.73127979
154Hyperphosphatemia (HP:0002905)1.72965745
155Tarsal synostosis (HP:0008368)1.71950313
156Abnormal pupillary function (HP:0007686)1.71247295
157Urinary urgency (HP:0000012)1.70976378
158Increased CSF lactate (HP:0002490)1.70689006
159Macroorchidism (HP:0000053)1.69540439
160Congenital glaucoma (HP:0001087)1.68631341
161Abnormal delivery (HP:0001787)1.68396085
162Decreased circulating renin level (HP:0003351)1.67911381
163Large for gestational age (HP:0001520)1.67786625
164Generalized hyperpigmentation (HP:0007440)1.66955728
165Segmental peripheral demyelination/remyelination (HP:0003481)1.66066740
166Gout (HP:0001997)1.65916274
167Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65313518
168Enlarged penis (HP:0000040)1.64970441
169Postural tremor (HP:0002174)1.64560875
170Slow saccadic eye movements (HP:0000514)1.64312433
171Type 2 muscle fiber atrophy (HP:0003554)1.63448093
172Gait imbalance (HP:0002141)1.63435796
173Morphological abnormality of the middle ear (HP:0008609)1.63181701
174Bilateral microphthalmos (HP:0007633)1.61534611
175Fatigable weakness (HP:0003473)1.60471781
176Abnormality of the neuromuscular junction (HP:0003398)1.60471781
177Synostosis involving bones of the lower limbs (HP:0009138)1.60211759
178Synostosis involving bones of the feet (HP:0009140)1.60211759
179Potter facies (HP:0002009)1.60060723
180Facial shape deformation (HP:0011334)1.60060723
181Vaginal atresia (HP:0000148)1.58854592
182Thin ribs (HP:0000883)1.58838600
183Spastic gait (HP:0002064)1.58306656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.66836494
2PLK44.23509459
3MINK13.66459037
4MAP3K123.58431703
5INSRR3.55514343
6MAPK153.38686975
7MARK13.36886682
8PASK3.16272853
9CASK3.09131246
10ERBB32.51599844
11DDR22.47805316
12MAP3K92.46046995
13LIMK12.34559520
14NTRK12.32970612
15MAP3K42.30877882
16PAK32.05979976
17WNK41.97542347
18MAP2K41.88331193
19CSNK1A1L1.86030333
20SCYL21.83957095
21EPHA41.83931746
22HIPK21.81597961
23PKN21.74396104
24EEF2K1.73365161
25GRK71.62972664
26IRAK21.56751750
27MAP3K21.56403792
28MAP2K71.55159157
29CSNK1G11.54174409
30ICK1.53928071
31PRKD31.53041095
32PIK3CG1.53007994
33UHMK11.51326515
34KSR21.45813598
35LMTK21.40250232
36PAK61.33537085
37MAP3K101.26405354
38EPHA31.21503528
39PHKG21.19540627
40PHKG11.19540627
41LATS21.18823371
42PRKCG1.18274388
43GRK51.15622531
44MAP3K11.15622166
45NTRK21.15430558
46TRIB31.11576160
47IRAK11.11418355
48MAPK131.11001024
49MUSK1.10672246
50MAP3K111.10421410
51CDK51.09809009
52TESK11.08589723
53LATS11.07823570
54MAPK121.06200936
55RET1.04408619
56NME11.03776970
57CAMK2G1.01280019
58PNCK1.00415418
59PIK3CA0.98846212
60CCNB10.98420468
61BCR0.96786774
62DYRK1A0.93421207
63PRKCE0.92983283
64OBSCN0.92585761
65WNK10.92152324
66ARAF0.89653629
67ADRBK10.89310653
68CDC42BPA0.88262848
69FER0.88197394
70CAMK2A0.87899485
71PTK20.83506715
72PDGFRA0.80781196
73MAPKAPK30.76755932
74IRAK30.76725835
75FGFR40.76318607
76CDK140.75561682
77MAP2K10.75083321
78NEK10.74955753
79BRAF0.74351780
80SGK2230.73848377
81SGK4940.73848377
82CAMK2D0.73769538
83SIK20.73205930
84ADRBK20.69957071
85PRKCH0.69137646
86STK38L0.68508532
87CAMKK20.67868394
88CDK190.67808738
89KSR10.67805944
90RIPK10.67615754
91TYRO30.67588713
92RPS6KA20.67031096
93AKT30.66082564
94MARK20.65478983
95CLK10.64909909
96FGR0.63163998
97BMPR1B0.62007789
98CAMKK10.61966002
99MAP3K60.61410938
100CDK180.61281355
101MOS0.61121789
102PRKG10.60867315
103STK160.60640817
104CDK150.57188740
105MAP2K20.55121036
106CSNK1D0.55049254
107TNIK0.51834795
108PRKCZ0.50557460
109RPS6KA30.50336512
110CAMK1G0.50127456
111MKNK20.50112157
112WNK30.49616662
113CAMK2B0.49369219
114CSNK1G20.48985349
115FGFR20.48618246
116CDK11A0.48463429
117PRKACB0.47027788
118DYRK20.45948910
119ERN10.45583324
120PRKACA0.45446496
121STK380.44764101
122CSNK1G30.44745156
123CSNK1A10.41331171
124TSSK60.40321546
125TESK20.40124815
126AKT20.37659726
127MAPK90.37538976
128TRPM70.37508366
129PRKCI0.36686424
130SIK30.36098330
131CSNK1E0.35187606
132SGK20.35137079
133STK390.34658153
134BRD40.34181689
135AURKA0.34100985
136PRKCB0.32703448
137EPHB10.32582380
138CAMK1D0.32292973
139PRKACG0.32182316
140MAPK40.31830481
141MAPK100.30485200
142PLK20.30335934
143DAPK20.29271366

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.06583741
2Synaptic vesicle cycle_Homo sapiens_hsa047213.42638556
3Protein export_Homo sapiens_hsa030602.99217654
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.91892513
5Vibrio cholerae infection_Homo sapiens_hsa051102.84127747
6Oxidative phosphorylation_Homo sapiens_hsa001902.81297558
7Insulin secretion_Homo sapiens_hsa049112.80101135
8Parkinsons disease_Homo sapiens_hsa050122.43959284
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.36194664
10Sulfur metabolism_Homo sapiens_hsa009202.13234525
11Collecting duct acid secretion_Homo sapiens_hsa049662.09356020
12Cocaine addiction_Homo sapiens_hsa050302.03256266
13GABAergic synapse_Homo sapiens_hsa047271.93299186
14Nicotine addiction_Homo sapiens_hsa050331.92092538
15Alzheimers disease_Homo sapiens_hsa050101.84398393
16Amphetamine addiction_Homo sapiens_hsa050311.84383146
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.81741150
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78452673
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.77383739
20Circadian entrainment_Homo sapiens_hsa047131.68278379
21Taste transduction_Homo sapiens_hsa047421.68258466
22Dopaminergic synapse_Homo sapiens_hsa047281.67262668
23Cardiac muscle contraction_Homo sapiens_hsa042601.66617605
24Cholinergic synapse_Homo sapiens_hsa047251.65077864
25Steroid biosynthesis_Homo sapiens_hsa001001.63436044
26Serotonergic synapse_Homo sapiens_hsa047261.58890429
27Huntingtons disease_Homo sapiens_hsa050161.58282128
28Type II diabetes mellitus_Homo sapiens_hsa049301.50190928
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.48235695
30Long-term potentiation_Homo sapiens_hsa047201.47314277
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44196495
32Morphine addiction_Homo sapiens_hsa050321.38667586
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30410019
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28000842
35Tight junction_Homo sapiens_hsa045301.20248938
36Olfactory transduction_Homo sapiens_hsa047401.19535548
37Butanoate metabolism_Homo sapiens_hsa006501.19140895
38Phototransduction_Homo sapiens_hsa047441.19085447
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16317658
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.16086067
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13160052
42Prion diseases_Homo sapiens_hsa050201.06272995
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05930633
44Pancreatic secretion_Homo sapiens_hsa049721.05013507
45Type I diabetes mellitus_Homo sapiens_hsa049401.03370275
46Gastric acid secretion_Homo sapiens_hsa049711.03325942
47Glutamatergic synapse_Homo sapiens_hsa047241.00228667
48Renin secretion_Homo sapiens_hsa049241.00126930
49Protein digestion and absorption_Homo sapiens_hsa049741.00071590
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99766655
51Gap junction_Homo sapiens_hsa045400.96658923
52Long-term depression_Homo sapiens_hsa047300.94250779
53Estrogen signaling pathway_Homo sapiens_hsa049150.93160076
54Thyroid hormone synthesis_Homo sapiens_hsa049180.92126734
55Salivary secretion_Homo sapiens_hsa049700.90567583
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89902571
57Thyroid cancer_Homo sapiens_hsa052160.85509033
58ECM-receptor interaction_Homo sapiens_hsa045120.84499392
59GnRH signaling pathway_Homo sapiens_hsa049120.83035765
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79911736
61Renin-angiotensin system_Homo sapiens_hsa046140.79818596
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77055983
63Focal adhesion_Homo sapiens_hsa045100.74303698
64Glucagon signaling pathway_Homo sapiens_hsa049220.74097648
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71422824
66Phenylalanine metabolism_Homo sapiens_hsa003600.70840489
67Oxytocin signaling pathway_Homo sapiens_hsa049210.69327011
68Alcoholism_Homo sapiens_hsa050340.67469955
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.67123734
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66987096
71N-Glycan biosynthesis_Homo sapiens_hsa005100.66309745
72Insulin signaling pathway_Homo sapiens_hsa049100.65385752
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65305416
74Fatty acid elongation_Homo sapiens_hsa000620.64437165
75Hedgehog signaling pathway_Homo sapiens_hsa043400.62719315
76Fatty acid biosynthesis_Homo sapiens_hsa000610.61594421
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60650352
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60447697
79Lysosome_Homo sapiens_hsa041420.60131952
80Phagosome_Homo sapiens_hsa041450.59967542
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59811277
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.57862419
83Regulation of autophagy_Homo sapiens_hsa041400.57360966
84cAMP signaling pathway_Homo sapiens_hsa040240.55784937
85Calcium signaling pathway_Homo sapiens_hsa040200.55396270
86Sulfur relay system_Homo sapiens_hsa041220.54629385
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53842312
88Oocyte meiosis_Homo sapiens_hsa041140.51569269
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.50943770
90Ras signaling pathway_Homo sapiens_hsa040140.49653337
91Rap1 signaling pathway_Homo sapiens_hsa040150.49196867
92Tryptophan metabolism_Homo sapiens_hsa003800.48858567
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48712076
94Bile secretion_Homo sapiens_hsa049760.48576423
95Melanogenesis_Homo sapiens_hsa049160.44846927
96Dilated cardiomyopathy_Homo sapiens_hsa054140.44279467
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43574925
98Wnt signaling pathway_Homo sapiens_hsa043100.42433959
99Prolactin signaling pathway_Homo sapiens_hsa049170.42297861
100Endometrial cancer_Homo sapiens_hsa052130.42211402
101Dorso-ventral axis formation_Homo sapiens_hsa043200.40499280
102ErbB signaling pathway_Homo sapiens_hsa040120.39567057
103Pyruvate metabolism_Homo sapiens_hsa006200.39049355
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38511354
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.38030206
106Tyrosine metabolism_Homo sapiens_hsa003500.37823925
107Galactose metabolism_Homo sapiens_hsa000520.36605202
108Circadian rhythm_Homo sapiens_hsa047100.36554462
109AMPK signaling pathway_Homo sapiens_hsa041520.36374492
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36113108
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36022994
112Axon guidance_Homo sapiens_hsa043600.34099091
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32425132
114Vitamin B6 metabolism_Homo sapiens_hsa007500.32251957
115Glioma_Homo sapiens_hsa052140.30556587
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30467467
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.30284722
118Choline metabolism in cancer_Homo sapiens_hsa052310.29029800
119Amoebiasis_Homo sapiens_hsa051460.27937016
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27768008
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27577883
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27317886
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26994460
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26865514
125Rheumatoid arthritis_Homo sapiens_hsa053230.26461718
126Ovarian steroidogenesis_Homo sapiens_hsa049130.25683782
127Insulin resistance_Homo sapiens_hsa049310.24225964
128MAPK signaling pathway_Homo sapiens_hsa040100.22599421
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22201776
130Starch and sucrose metabolism_Homo sapiens_hsa005000.21840639

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