ARHGAP39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.04467627
2cilium or flagellum-dependent cell motility (GO:0001539)6.75155792
3motile cilium assembly (GO:0044458)6.30260134
4cilium movement (GO:0003341)5.57767192
5positive regulation of dendritic spine morphogenesis (GO:0061003)4.68513874
6synaptic vesicle endocytosis (GO:0048488)4.63779796
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.41601325
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.39536962
9epithelial cilium movement (GO:0003351)4.35658037
10semaphorin-plexin signaling pathway (GO:0071526)4.28157642
11lung epithelium development (GO:0060428)4.23751565
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.22162640
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.21431002
14left/right pattern formation (GO:0060972)4.18054944
15locomotory exploration behavior (GO:0035641)4.16229926
16planar cell polarity pathway involved in neural tube closure (GO:0090179)4.15655005
17synaptic vesicle maturation (GO:0016188)3.99019305
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.95221288
19regulation of glutamate receptor signaling pathway (GO:1900449)3.90970587
20positive regulation of protein homooligomerization (GO:0032464)3.88749661
21synaptic vesicle exocytosis (GO:0016079)3.86980958
22protein localization to synapse (GO:0035418)3.86183903
23cell migration in hindbrain (GO:0021535)3.83036065
24regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.80139330
25synaptic transmission, glutamatergic (GO:0035249)3.79193989
26regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.73192190
27regulation of neuronal synaptic plasticity (GO:0048168)3.70668814
28vocalization behavior (GO:0071625)3.65658341
29glutamate receptor signaling pathway (GO:0007215)3.59927056
30poly(A)+ mRNA export from nucleus (GO:0016973)3.57753507
31cytoskeletal anchoring at plasma membrane (GO:0007016)3.55878341
32cell-cell junction maintenance (GO:0045217)3.51078981
33apical protein localization (GO:0045176)3.51067876
34central nervous system projection neuron axonogenesis (GO:0021952)3.49737538
35neuromuscular process controlling balance (GO:0050885)3.40756721
36axoneme assembly (GO:0035082)3.38997870
37regulation of respiratory system process (GO:0044065)3.37211779
38positive regulation of dendritic spine development (GO:0060999)3.36125407
39replication fork processing (GO:0031297)3.35315276
40regulation of long-term neuronal synaptic plasticity (GO:0048169)3.34426311
41cerebellar granule cell differentiation (GO:0021707)3.29355873
42regulation of dendritic spine morphogenesis (GO:0061001)3.29170628
43asymmetric protein localization (GO:0008105)3.27666190
44synaptic vesicle docking involved in exocytosis (GO:0016081)3.25718990
45dendritic spine morphogenesis (GO:0060997)3.25177607
46neuron cell-cell adhesion (GO:0007158)3.23659496
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.23103467
48exploration behavior (GO:0035640)3.20230812
49transcription from mitochondrial promoter (GO:0006390)3.18915774
50microtubule bundle formation (GO:0001578)3.18896115
51ventricular system development (GO:0021591)3.16898983
52proline biosynthetic process (GO:0006561)3.15415246
53signal complex assembly (GO:0007172)3.14643790
54glutamate secretion (GO:0014047)3.14186918
55histone H4-K12 acetylation (GO:0043983)3.12544753
56regulation of cAMP-dependent protein kinase activity (GO:2000479)3.10862104
57neuromuscular process controlling posture (GO:0050884)3.10337200
58establishment of planar polarity (GO:0001736)3.09308307
59establishment of tissue polarity (GO:0007164)3.09308307
60establishment or maintenance of apical/basal cell polarity (GO:0035088)3.05741608
61establishment or maintenance of bipolar cell polarity (GO:0061245)3.05741608
62regulation of postsynaptic membrane potential (GO:0060078)3.04585371
63regulation of integrin activation (GO:0033623)3.01479151
64neuronal action potential propagation (GO:0019227)3.01286086
65regulation of respiratory gaseous exchange (GO:0043576)3.00833655
66neuron-neuron synaptic transmission (GO:0007270)3.00824477
67long-term memory (GO:0007616)3.00337878
68dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.99848938
69regulation of protein homooligomerization (GO:0032462)2.99811479
70establishment of apical/basal cell polarity (GO:0035089)2.99530164
71neuromuscular process (GO:0050905)2.99439702
72regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.99016025
73DNA strand renaturation (GO:0000733)2.97389799
74establishment or maintenance of monopolar cell polarity (GO:0061339)2.96020339
75establishment of monopolar cell polarity (GO:0061162)2.96020339
76Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.94694730
77glial cell migration (GO:0008347)2.91975791
78cellular response to ATP (GO:0071318)2.90182546
79regulation of synaptic plasticity (GO:0048167)2.88668360
80embryonic process involved in female pregnancy (GO:0060136)2.87425144
81nerve growth factor signaling pathway (GO:0038180)2.84934923
82regulation of synaptic vesicle exocytosis (GO:2000300)2.83924739
83transmission of nerve impulse (GO:0019226)2.83025420
84gamma-aminobutyric acid transport (GO:0015812)2.81294875
85positive regulation of synapse maturation (GO:0090129)2.81108626
86membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.79613161
87axonal fasciculation (GO:0007413)2.78424808
88neuron recognition (GO:0008038)2.77068072
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.76767209
90vitamin transmembrane transport (GO:0035461)2.76249098
91cell junction maintenance (GO:0034331)2.74429412
92protein retention in ER lumen (GO:0006621)2.74351539
93regulation of establishment of planar polarity (GO:0090175)2.74106942
94dendrite morphogenesis (GO:0048813)2.73272381
95membrane depolarization during action potential (GO:0086010)2.72604612
96membrane depolarization (GO:0051899)2.70242917
97sodium ion export (GO:0071436)2.70037879
98central nervous system neuron axonogenesis (GO:0021955)2.69825365
99cerebellar Purkinje cell differentiation (GO:0021702)2.69656529
100positive regulation of developmental pigmentation (GO:0048087)2.69350470
101peptidyl-tyrosine autophosphorylation (GO:0038083)2.68753386
102maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.68264744
103regulation of synaptic vesicle transport (GO:1902803)2.68261013
104regulation of synapse maturation (GO:0090128)2.68022542
105G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.66630381
106regulation of dendritic spine development (GO:0060998)2.65792955
107positive regulation of receptor recycling (GO:0001921)2.65671903
108regulation of ARF GTPase activity (GO:0032312)2.65422149
109dendritic spine organization (GO:0097061)2.64848454
110positive regulation of smoothened signaling pathway (GO:0045880)2.63378017
111L-amino acid import (GO:0043092)2.63166124
112layer formation in cerebral cortex (GO:0021819)2.62575579
113adult walking behavior (GO:0007628)2.62092506
114neuronal ion channel clustering (GO:0045161)2.60928520
115ear development (GO:0043583)2.60074132
116auditory receptor cell stereocilium organization (GO:0060088)2.59486891
117dopamine receptor signaling pathway (GO:0007212)2.59028772
118innervation (GO:0060384)2.58208415
119oxidative demethylation (GO:0070989)2.57957001
120learning (GO:0007612)2.56680663
121postsynaptic membrane organization (GO:0001941)2.56314519
122regulation of synapse structural plasticity (GO:0051823)2.55514800
123positive regulation of membrane potential (GO:0045838)2.54985212
124glycine transport (GO:0015816)2.54764840
125desmosome organization (GO:0002934)2.52932891
126camera-type eye morphogenesis (GO:0048593)2.52496374
127activation of Rac GTPase activity (GO:0032863)2.51918176
128positive regulation of synaptic transmission, GABAergic (GO:0032230)2.50288327
129mating behavior (GO:0007617)2.49103961
130positive regulation of dendrite morphogenesis (GO:0050775)2.48902867
131chemosensory behavior (GO:0007635)2.48611412
132regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.47983819
133negative regulation of Ras GTPase activity (GO:0034261)2.47804523
134maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.47705163
135primary alcohol catabolic process (GO:0034310)2.47079618
136startle response (GO:0001964)2.45798326
137cellular potassium ion homeostasis (GO:0030007)2.45774107
138convergent extension (GO:0060026)2.44904719
139epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.44661691
140microtubule-based movement (GO:0007018)2.43959152
141labyrinthine layer development (GO:0060711)2.43771511
142negative regulation of JAK-STAT cascade (GO:0046426)2.43768616
143regulation of vesicle fusion (GO:0031338)2.43450733
144phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.41664829
145sperm capacitation (GO:0048240)2.40285861
146epithelial cell-cell adhesion (GO:0090136)2.37883819
147negative regulation of catenin import into nucleus (GO:0035414)2.36142788
148lateral sprouting from an epithelium (GO:0060601)2.35023043
149glomerular epithelial cell development (GO:0072310)2.33588187
150adherens junction assembly (GO:0034333)2.32134190
151endothelial cell chemotaxis (GO:0035767)2.31154883
152regulation of microtubule depolymerization (GO:0031114)2.29637336
153neurotransmitter secretion (GO:0007269)2.27805103
154non-canonical Wnt signaling pathway (GO:0035567)2.24412635
155regulation of chromatin binding (GO:0035561)2.24377239
156renal system development (GO:0072001)2.24242408
157cochlea morphogenesis (GO:0090103)2.24134589
158negative regulation of cell size (GO:0045792)2.23672704
159regulation of mammary gland epithelial cell proliferation (GO:0033599)2.23504068
160regulation of ARF protein signal transduction (GO:0032012)2.22566193
161embryonic camera-type eye development (GO:0031076)2.21480932
162cellular component maintenance (GO:0043954)2.21233533
163neuroblast proliferation (GO:0007405)2.20607399
164left/right axis specification (GO:0070986)2.19527104
165notochord development (GO:0030903)2.18771664
166regulation of NFAT protein import into nucleus (GO:0051532)2.17961555
167negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.13722082
168amino acid import (GO:0043090)2.12974533
169auditory behavior (GO:0031223)2.12692701
170negative regulation of T cell differentiation in thymus (GO:0033085)2.11969174
171adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.11630727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.66792231
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.79829421
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.93686247
4GBX2_23144817_ChIP-Seq_PC3_Human2.71610519
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.60575165
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.60168629
7REST_21632747_ChIP-Seq_MESCs_Mouse2.59436512
8DROSHA_22980978_ChIP-Seq_HELA_Human2.52005489
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.50705327
10RACK7_27058665_Chip-Seq_MCF-7_Human2.37230794
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.36161170
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.30068367
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.23389579
14CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.21161700
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15132650
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08577811
17P68_20966046_ChIP-Seq_HELA_Human2.08006360
18RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.07938876
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.04438439
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.00601938
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00172762
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97592861
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.96558290
24* SMC4_20622854_ChIP-Seq_HELA_Human1.93959529
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.93814555
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90852439
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.85946019
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85623754
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85623754
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85024626
31ZNF263_19887448_ChIP-Seq_K562_Human1.82457121
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80537633
33CREB1_26743006_Chip-Seq_LNCaP_Human1.79791478
34RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.77778192
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77084019
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77039461
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.76346905
38RUNX1_27514584_Chip-Seq_MCF-7_Human1.73906638
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.70535081
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.70370671
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.70370671
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.70370671
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70355390
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.69209207
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.68532823
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68180049
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67314988
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.66931114
49CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.65005651
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.64125918
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.63843172
52ZFP281_27345836_Chip-Seq_ESCs_Mouse1.61105049
53UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.59236328
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58531932
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.56315105
56SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55703859
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55318467
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54662667
59KDM2B_26808549_Chip-Seq_K562_Human1.52918458
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.51941637
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50906972
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48549946
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.45291905
64AR_21572438_ChIP-Seq_LNCaP_Human1.44449825
65VDR_21846776_ChIP-Seq_THP-1_Human1.44351643
66SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40446206
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40185388
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38663643
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37750238
70TP53_22127205_ChIP-Seq_IMR90_Human1.37579733
71MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.35069832
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34392079
73EED_16625203_ChIP-ChIP_MESCs_Mouse1.33813932
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31569961
75POU5F1_16518401_ChIP-PET_MESCs_Mouse1.28423076
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.28136411
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.26934594
78TP63_22573176_ChIP-Seq_HFKS_Human1.25911843
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.25385605
80TCF7_22412390_ChIP-Seq_EML_Mouse1.25087009
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25055727
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23949637
83ESR1_20079471_ChIP-ChIP_T-47D_Human1.22755879
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21563954
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21541741
86RNF2_27304074_Chip-Seq_NSC_Mouse1.20909142
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18425123
88TET1_21490601_ChIP-Seq_MESCs_Mouse1.17055295
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15176433
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15176433
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15156255
92PHF8_20622854_ChIP-Seq_HELA_Human1.14764423
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13499812
94CTCF_27219007_Chip-Seq_Bcells_Human1.13499048
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13137999
96SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.12368640
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11751304
98P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10994333
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10910199
100EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10858203
101BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10512911
102LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09228364
103RARA_24833708_ChIP-Seq_LIVER_Mouse1.08749166
104SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.08261381
105RARB_24833708_ChIP-Seq_LIVER_Mouse1.08241052
106ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07927052
107AR_19668381_ChIP-Seq_PC3_Human1.07371256
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06628775
109KLF5_25053715_ChIP-Seq_YYC3_Human1.06292092
110CTCF_20526341_ChIP-Seq_ESCs_Human1.06246881
111EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05961341
112ELF1_20517297_ChIP-Seq_JURKAT_Human1.04590183
113BCOR_27268052_Chip-Seq_Bcells_Human1.03737721
114E2F1_20622854_ChIP-Seq_HELA_Human1.02742478
115* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02188488
116* LXR_22292898_ChIP-Seq_THP-1_Human1.02029741
117SMAD4_21799915_ChIP-Seq_A2780_Human1.00778056
118ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00609309
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99786084
120STAT3_23295773_ChIP-Seq_U87_Human0.99776502
121TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99212157
122NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99078071
123CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98745013
124PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98732185
125OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98049507
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97576445
127SMAD3_21741376_ChIP-Seq_HESCs_Human0.97541516
128PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.96969035
129YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95240954
130TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95189685
131TCF4_23295773_ChIP-Seq_U87_Human0.94959178
132THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94312108
133STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94221088
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94120693
135KDM2B_26808549_Chip-Seq_DND41_Human0.93895645
136AHR_22903824_ChIP-Seq_MCF-7_Human0.93246436
137CBX2_27304074_Chip-Seq_ESCs_Mouse0.92835407
138NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92614641
139OCT4_19829295_ChIP-Seq_ESCs_Human0.92597679
140TP53_20018659_ChIP-ChIP_R1E_Mouse0.92121379
141NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.90803562
142DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90501067
143PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89291767
144PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89227400
145TP53_23651856_ChIP-Seq_MEFs_Mouse0.88515695
146DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87019517
147GATA1_26923725_Chip-Seq_HPCs_Mouse0.84853257
148SOX2_21211035_ChIP-Seq_LN229_Gbm0.83696888
149STAT3_18555785_ChIP-Seq_MESCs_Mouse0.83349960
150KDM2B_26808549_Chip-Seq_JURKAT_Human0.82803261
151TBL1_22424771_ChIP-Seq_293T_Human0.82498174
152TBX3_20139965_ChIP-Seq_ESCs_Mouse0.82362036
153TBX3_20139965_ChIP-Seq_MESCs_Mouse0.82061109
154SMAD3_21741376_ChIP-Seq_ESCs_Human0.80304676

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.19302751
2MP0003880_abnormal_central_pattern3.35328376
3MP0005171_absent_coat_pigmentation3.25311750
4MP0003635_abnormal_synaptic_transmissio3.18102572
5MP0000566_synostosis3.13821359
6MP0002063_abnormal_learning/memory/cond2.79582879
7MP0001968_abnormal_touch/_nociception2.56318029
8MP0004270_analgesia2.52474387
9MP0003705_abnormal_hypodermis_morpholog2.47892225
10MP0009046_muscle_twitch2.46840087
11MP0009745_abnormal_behavioral_response2.44092902
12MP0002064_seizures2.44068128
13MP0002735_abnormal_chemical_nociception2.40212716
14MP0002572_abnormal_emotion/affect_behav2.40054783
15MP0009780_abnormal_chondrocyte_physiolo2.22754392
16MP0005623_abnormal_meninges_morphology2.21796902
17MP0008057_abnormal_DNA_replication2.08146414
18MP0008877_abnormal_DNA_methylation2.07727864
19MP0005423_abnormal_somatic_nervous2.01240210
20MP0000778_abnormal_nervous_system2.00078287
21MP0002272_abnormal_nervous_system1.97624798
22MP0002736_abnormal_nociception_after1.95069797
23MP0003787_abnormal_imprinting1.93062619
24MP0001970_abnormal_pain_threshold1.92913857
25MP0001486_abnormal_startle_reflex1.90114126
26MP0001346_abnormal_lacrimal_gland1.89449364
27MP0008995_early_reproductive_senescence1.89381862
28MP0002733_abnormal_thermal_nociception1.87886709
29MP0010234_abnormal_vibrissa_follicle1.86861542
30MP0005076_abnormal_cell_differentiation1.81990388
31MP0000015_abnormal_ear_pigmentation1.78981522
32MP0001849_ear_inflammation1.76025504
33MP0002734_abnormal_mechanical_nocicepti1.74786349
34MP0000678_abnormal_parathyroid_gland1.74743966
35MP0000955_abnormal_spinal_cord1.73883668
36MP0005174_abnormal_tail_pigmentation1.72310305
37MP0002653_abnormal_ependyma_morphology1.67312302
38MP0006292_abnormal_olfactory_placode1.66116204
39MP0004811_abnormal_neuron_physiology1.64050217
40MP0005645_abnormal_hypothalamus_physiol1.62122105
41MP0003172_abnormal_lysosome_physiology1.62015896
42MP0002184_abnormal_innervation1.61971976
43MP0002067_abnormal_sensory_capabilities1.59080032
44MP0008875_abnormal_xenobiotic_pharmacok1.55485319
45MP0000537_abnormal_urethra_morphology1.55391734
46MP0009278_abnormal_bone_marrow1.49232482
47MP0002882_abnormal_neuron_morphology1.42697602
48MP0002089_abnormal_postnatal_growth/wei1.42535810
49MP0001440_abnormal_grooming_behavior1.42386159
50MP0001348_abnormal_lacrimal_gland1.41776023
51MP0004233_abnormal_muscle_weight1.41609615
52MP0003283_abnormal_digestive_organ1.41576806
53MP0000569_abnormal_digit_pigmentation1.37567569
54MP0008569_lethality_at_weaning1.36239860
55MP0002557_abnormal_social/conspecific_i1.34931051
56MP0004885_abnormal_endolymph1.34697158
57MP0003942_abnormal_urinary_system1.32699487
58MP0000751_myopathy1.32187320
59MP0003123_paternal_imprinting1.28959049
60MP0004142_abnormal_muscle_tone1.27979165
61MP0001502_abnormal_circadian_rhythm1.26911937
62MP0001188_hyperpigmentation1.26405692
63MP0003453_abnormal_keratinocyte_physiol1.26388962
64MP0000383_abnormal_hair_follicle1.23915106
65MP0005377_hearing/vestibular/ear_phenot1.23585925
66MP0003878_abnormal_ear_physiology1.23585925
67MP0001501_abnormal_sleep_pattern1.22312768
68MP0003633_abnormal_nervous_system1.20758594
69MP0001299_abnormal_eye_distance/1.20482942
70MP0003329_amyloid_beta_deposits1.18832866
71MP0002066_abnormal_motor_capabilities/c1.18713653
72MP0002009_preneoplasia1.16088294
73MP0004133_heterotaxia1.15460774
74MP0002152_abnormal_brain_morphology1.15088385
75MP0002098_abnormal_vibrissa_morphology1.12484062
76MP0005257_abnormal_intraocular_pressure1.11970122
77MP0000467_abnormal_esophagus_morphology1.11249556
78MP0006072_abnormal_retinal_apoptosis1.09648932
79MP0004858_abnormal_nervous_system1.08422377
80MP0000534_abnormal_ureter_morphology1.08248611
81MP0010678_abnormal_skin_adnexa1.07763034
82MP0005646_abnormal_pituitary_gland1.04991192
83MP0000762_abnormal_tongue_morphology1.04985199
84MP0002909_abnormal_adrenal_gland1.04674166
85MP0000462_abnormal_digestive_system1.04610125
86MP0005386_behavior/neurological_phenoty1.04501725
87MP0004924_abnormal_behavior1.04501725
88MP0003045_fibrosis1.04261304
89MP0000049_abnormal_middle_ear1.04220071
90MP0003631_nervous_system_phenotype1.02652155
91MP0003634_abnormal_glial_cell1.01866995
92MP0005394_taste/olfaction_phenotype1.00950532
93MP0005499_abnormal_olfactory_system1.00950532
94MP0002160_abnormal_reproductive_system0.99252601
95MP0009384_cardiac_valve_regurgitation0.97880268
96MP0002796_impaired_skin_barrier0.97323418
97MP0002932_abnormal_joint_morphology0.95929316
98MP0005501_abnormal_skin_physiology0.95555718
99MP0002752_abnormal_somatic_nervous0.94423736
100MP0000003_abnormal_adipose_tissue0.94306563
101MP0003861_abnormal_nervous_system0.93802279
102MP0002282_abnormal_trachea_morphology0.93748986
103MP0003890_abnormal_embryonic-extraembry0.90932271
104MP0008789_abnormal_olfactory_epithelium0.90820669
105MP0003937_abnormal_limbs/digits/tail_de0.90401787
106MP0001963_abnormal_hearing_physiology0.90222319
107MP0001984_abnormal_olfaction0.89944131
108MP0000013_abnormal_adipose_tissue0.89435714
109MP0003119_abnormal_digestive_system0.88493566
110MP0001485_abnormal_pinna_reflex0.87527715
111MP0003879_abnormal_hair_cell0.87389867
112MP0002229_neurodegeneration0.86645914
113MP0002249_abnormal_larynx_morphology0.86591160
114MP0003075_altered_response_to0.85478468
115MP0003115_abnormal_respiratory_system0.84900765
116MP0005551_abnormal_eye_electrophysiolog0.82080739
117MP0002751_abnormal_autonomic_nervous0.81683714
118MP0005248_abnormal_Harderian_gland0.81470417
119MP0004043_abnormal_pH_regulation0.81149210
120MP0003938_abnormal_ear_development0.80948476
121MP0003698_abnormal_male_reproductive0.80601694
122MP0002697_abnormal_eye_size0.79446570
123MP0004510_myositis0.77698426
124MP0001340_abnormal_eyelid_morphology0.77637398
125MP0005075_abnormal_melanosome_morpholog0.76804035
126MP0002233_abnormal_nose_morphology0.76686378
127MP0004145_abnormal_muscle_electrophysio0.75902092
128MP0002822_catalepsy0.75695110
129MP0009379_abnormal_foot_pigmentation0.75558368
130MP0003632_abnormal_nervous_system0.75024576
131MP0002111_abnormal_tail_morphology0.74998564
132MP0000733_abnormal_muscle_development0.74475028
133MP0005253_abnormal_eye_physiology0.73532004
134MP0003935_abnormal_craniofacial_develop0.73356057
135MP0009053_abnormal_anal_canal0.73218843
136MP0003137_abnormal_impulse_conducting0.73158355
137MP0004742_abnormal_vestibular_system0.72750499
138MP0001664_abnormal_digestion0.72489717
139MP0005410_abnormal_fertilization0.72278178
140MP0000371_diluted_coat_color0.71268291
141MP0005409_darkened_coat_color0.70992745
142MP0010030_abnormal_orbit_morphology0.69171499
143MP0002075_abnormal_coat/hair_pigmentati0.66830264
144MP0000026_abnormal_inner_ear0.65889377
145MP0001324_abnormal_eye_pigmentation0.65761709
146MP0000920_abnormal_myelination0.63674961
147MP0000631_abnormal_neuroendocrine_gland0.63401036
148MP0010768_mortality/aging0.63398224
149MP0003136_yellow_coat_color0.62884862
150MP0010769_abnormal_survival0.61657210
151MP0000579_abnormal_nail_morphology0.59260977
152MP0010770_preweaning_lethality0.58121950
153MP0002082_postnatal_lethality0.58121950
154MP0003690_abnormal_glial_cell0.57665918
155MP0002116_abnormal_craniofacial_bone0.57655394
156MP0008874_decreased_physiological_sensi0.56446527

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.21196675
2Abnormal respiratory motile cilium physiology (HP:0012261)6.11644398
3Absent/shortened dynein arms (HP:0200106)5.98057220
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.98057220
5Abnormal ciliary motility (HP:0012262)5.92194650
6Rhinitis (HP:0012384)5.47955823
7Myokymia (HP:0002411)5.38765636
8Focal motor seizures (HP:0011153)4.82492849
9Febrile seizures (HP:0002373)4.51403189
10Chronic bronchitis (HP:0004469)4.43166474
11Annular pancreas (HP:0001734)4.12268468
12Nasal polyposis (HP:0100582)3.90652813
13Bronchiectasis (HP:0002110)3.48305547
14Epileptic encephalopathy (HP:0200134)3.47504803
15Focal seizures (HP:0007359)3.35488387
16Intestinal atresia (HP:0011100)3.20978873
17Atelectasis (HP:0100750)3.15736625
18Progressive cerebellar ataxia (HP:0002073)3.13864080
19Abnormality of the nasal mucosa (HP:0000433)3.13408798
20Intestinal fistula (HP:0100819)3.10916955
21Ulnar bowing (HP:0003031)3.08144396
22Obstructive sleep apnea (HP:0002870)3.03201989
23Atonic seizures (HP:0010819)2.96829658
24Visual hallucinations (HP:0002367)2.94262140
25Rectovaginal fistula (HP:0000143)2.88319576
26Rectal fistula (HP:0100590)2.88319576
27Bell-shaped thorax (HP:0001591)2.87204165
28Rib fusion (HP:0000902)2.86475057
29Infertility (HP:0000789)2.77938014
30Occipital encephalocele (HP:0002085)2.71453706
31Hyperacusis (HP:0010780)2.69771136
32Facial hemangioma (HP:0000329)2.66510172
33Distal upper limb amyotrophy (HP:0007149)2.58469269
34Upper limb amyotrophy (HP:0009129)2.58469269
35Action tremor (HP:0002345)2.56265174
36Abnormality of the lower motor neuron (HP:0002366)2.49401907
37Clumsiness (HP:0002312)2.42812918
38Hand muscle atrophy (HP:0009130)2.42105843
39Absence seizures (HP:0002121)2.31400413
40Gaze-evoked nystagmus (HP:0000640)2.29502278
41Broad-based gait (HP:0002136)2.29175554
42Abnormal respiratory epithelium morphology (HP:0012253)2.26763244
43Abnormal respiratory motile cilium morphology (HP:0005938)2.26763244
44Vaginal fistula (HP:0004320)2.24167446
45Concave nail (HP:0001598)2.22878228
46Stridor (HP:0010307)2.22551608
47Genetic anticipation (HP:0003743)2.21533084
48Abnormality of the aortic arch (HP:0012303)2.21520658
49Urethral obstruction (HP:0000796)2.21462419
50Bronchomalacia (HP:0002780)2.21295068
51Dialeptic seizures (HP:0011146)2.19934404
52Fetal akinesia sequence (HP:0001989)2.19074344
53Turricephaly (HP:0000262)2.18266145
54Aqueductal stenosis (HP:0002410)2.17189580
55Dysdiadochokinesis (HP:0002075)2.13069752
56Increased IgM level (HP:0003496)2.10521256
57Dysmetria (HP:0001310)2.10416195
58Recurrent otitis media (HP:0000403)2.09787725
59Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.09485430
60Absent epiphyses (HP:0010577)2.09485430
61Flat acetabular roof (HP:0003180)2.09275478
62Mutism (HP:0002300)2.08027192
63Ocular albinism (HP:0001107)2.07934230
64Shallow orbits (HP:0000586)2.06517228
65Testicular atrophy (HP:0000029)2.05922004
66Ulnar claw (HP:0001178)2.04708122
67Spinal cord compression (HP:0002176)2.04478433
68Acute lymphatic leukemia (HP:0006721)2.04431371
69Alacrima (HP:0000522)2.03949803
70Postural instability (HP:0002172)2.02570120
71Supranuclear gaze palsy (HP:0000605)2.01038267
72Bowed forearm bones (HP:0003956)2.00058189
73Bowing of the arm (HP:0006488)2.00058189
74Urinary bladder sphincter dysfunction (HP:0002839)1.99240685
75Progressive sensorineural hearing impairment (HP:0000408)1.97996999
76Hypotelorism (HP:0000601)1.95720494
77Cervical subluxation (HP:0003308)1.95625754
78Iris hypopigmentation (HP:0007730)1.94691547
79Anteriorly placed anus (HP:0001545)1.94606065
80Broad face (HP:0000283)1.94490619
81Narrow nasal bridge (HP:0000446)1.93100362
82Aplasia of the musculature (HP:0100854)1.92905716
83Generalized tonic-clonic seizures (HP:0002069)1.91943464
84Aplasia involving bones of the upper limbs (HP:0009823)1.91162135
85Aplasia of the phalanges of the hand (HP:0009802)1.91162135
86Aplasia involving bones of the extremities (HP:0009825)1.91162135
87Ankle clonus (HP:0011448)1.91046602
88Gastrointestinal atresia (HP:0002589)1.89531043
89Short nail (HP:0001799)1.87048575
90Thin bony cortex (HP:0002753)1.86894333
91Choroideremia (HP:0001139)1.86509109
92Median cleft lip (HP:0000161)1.86294427
93Tented upper lip vermilion (HP:0010804)1.84823530
94Abnormality of the distal phalanges of the toes (HP:0010182)1.83704546
95Orthostatic hypotension (HP:0001278)1.80609277
96Absent speech (HP:0001344)1.80409892
97Congenital hip dislocation (HP:0001374)1.79977789
98Male infertility (HP:0003251)1.79789353
99Coronal craniosynostosis (HP:0004440)1.78394698
100Hemiparesis (HP:0001269)1.78378576
101Sleep apnea (HP:0010535)1.77635133
102Impaired smooth pursuit (HP:0007772)1.75904615
103Insomnia (HP:0100785)1.75229384
104Spinal muscular atrophy (HP:0007269)1.73473462
105Broad distal phalanx of finger (HP:0009836)1.72809123
106Short chin (HP:0000331)1.71437480
107Vertebral arch anomaly (HP:0008438)1.70473914
108Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.70299383
109Cystic liver disease (HP:0006706)1.69986938
110Decreased lacrimation (HP:0000633)1.69932095
111Abnormality of the labia minora (HP:0012880)1.69541589
112Volvulus (HP:0002580)1.69303078
113Abnormality of mucopolysaccharide metabolism (HP:0011020)1.67977673
114Abnormality of polysaccharide metabolism (HP:0011012)1.67977673
115Abnormality of glycosaminoglycan metabolism (HP:0004371)1.67977673
116Supernumerary ribs (HP:0005815)1.67906760
117Down-sloping shoulders (HP:0200021)1.67436297
118Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.66421930
119Vertebral clefting (HP:0008428)1.66071785
120Pustule (HP:0200039)1.64393565
121Alopecia of scalp (HP:0002293)1.64349039
122Pointed chin (HP:0000307)1.63333940
123Short femoral neck (HP:0100864)1.63281845
124Abnormality of the periventricular white matter (HP:0002518)1.63255327
125Akinesia (HP:0002304)1.62676120
126Abnormality of the nasal septum (HP:0000419)1.62215811
127Impaired vibration sensation in the lower limbs (HP:0002166)1.61630014
128Thin ribs (HP:0000883)1.61385244
129Abnormality of male internal genitalia (HP:0000022)1.61360636
130Progressive hearing impairment (HP:0001730)1.59703272
131Gastroesophageal reflux (HP:0002020)1.59122738
132Glioma (HP:0009733)1.58767928
133Gait imbalance (HP:0002141)1.58278890
134Astrocytoma (HP:0009592)1.57961698
135Abnormality of the astrocytes (HP:0100707)1.57961698
136Increased number of teeth (HP:0011069)1.57187519
137Bronchitis (HP:0012387)1.56975080
138Small hand (HP:0200055)1.55476755
139Urinary glycosaminoglycan excretion (HP:0003541)1.55411304
140Mucopolysacchariduria (HP:0008155)1.55411304
141Pterygium (HP:0001059)1.55001918
142Absent radius (HP:0003974)1.54725335
143Specific learning disability (HP:0001328)1.54714096
144Hypoplasia of the capital femoral epiphysis (HP:0003090)1.53847963
145Thickened helices (HP:0000391)1.53816865
146Truncal ataxia (HP:0002078)1.53747548
147Neurofibrillary tangles (HP:0002185)1.53703737
148Intention tremor (HP:0002080)1.53518968
149Hamartoma (HP:0010566)1.52882836
150Albinism (HP:0001022)1.52551333
151Exotropia (HP:0000577)1.52534667
152Inappropriate behavior (HP:0000719)1.52531603
153Distal lower limb muscle weakness (HP:0009053)1.50752088
154Abnormality of dentin (HP:0010299)1.49932459
155Abnormal vertebral ossification (HP:0100569)1.48916162
156Flattened epiphyses (HP:0003071)1.48880740
157Chronic hepatic failure (HP:0100626)1.48127416
158Renal dysplasia (HP:0000110)1.47094944
159Cerebral aneurysm (HP:0004944)1.47053699
160Bifid scrotum (HP:0000048)1.46258776
161Hyperactive renin-angiotensin system (HP:0000841)1.46225072
162Self-mutilation (HP:0000742)1.46104837
163Diaphragmatic weakness (HP:0009113)1.43012030
164Choanal stenosis (HP:0000452)1.42825558
165Abnormality of permanent molar morphology (HP:0011071)1.41750133
166Abnormality of the dental root (HP:0006486)1.41750133
167Taurodontia (HP:0000679)1.41750133
168Aplasia/hypoplasia of the femur (HP:0005613)1.41033984
169Popliteal pterygium (HP:0009756)1.38764764
170Arnold-Chiari malformation (HP:0002308)1.38458919
171Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.37225794
172Short thorax (HP:0010306)1.37045451
173Overriding aorta (HP:0002623)1.36368604
174Elfin facies (HP:0004428)1.35331567
175Lip pit (HP:0100267)1.34522032
176Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.34450499
177Renovascular hypertension (HP:0100817)1.34351105
178Germ cell neoplasia (HP:0100728)1.34291835
179Polycystic kidney dysplasia (HP:0000113)1.32727629
180Nuclear cataract (HP:0100018)1.32262651
181Long toe (HP:0010511)1.32261979
182Cerebral inclusion bodies (HP:0100314)1.29899985
183Abnormality of molar (HP:0011077)1.28593882

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.39887277
2TRIB34.35685313
3NTRK33.76755005
4ICK3.67136508
5MAPK153.54498125
6EPHA43.36057813
7MAP3K63.32037834
8SIK12.88258454
9DDR22.78351128
10PRPF4B2.75337041
11MARK12.75006122
12PINK12.74244645
13MAP3K92.48632821
14EEF2K2.46452207
15RIPK12.43682279
16DAPK12.37987321
17SMG12.25852106
18MST1R2.12195118
19PRKD22.00733726
20TYRO31.96138540
21UHMK11.92562476
22FGR1.91894610
23NTRK21.91808914
24MAP3K111.88931164
25MATK1.76666463
26LATS21.59676174
27PKN21.54206927
28PRKD31.53744371
29MINK11.50764388
30YES11.49740761
31PAK61.49510558
32RIPK41.47735197
33MET1.47129584
34MAP3K41.46554633
35STK381.42711462
36CDC42BPA1.39955026
37SIK21.39734774
38PTK21.39311682
39LMTK21.35049812
40TESK11.32082099
41MAP2K71.27646908
42AKT31.26482913
43DAPK21.23566269
44NME11.17280225
45BMX1.14487539
46CAMK2B1.13142329
47MTOR1.08241946
48CAMKK11.08016333
49BRD41.06341581
50PHKG21.06284314
51PHKG11.06284314
52ARAF1.03528503
53MAPK131.02300716
54CDK50.99961581
55TAOK10.99479178
56MUSK0.98358911
57PRKCI0.95453878
58RPS6KA20.94550341
59GRK50.87497398
60ERBB20.86953360
61PTK60.85829073
62CLK10.85054183
63MARK20.84871980
64CAMK2A0.84400190
65PDGFRA0.84089684
66TNIK0.82723523
67MAP3K100.81860991
68MAPKAPK30.79813165
69CSK0.79578196
70TRPM70.78990328
71PAK40.77261615
72FES0.76983365
73TAOK20.73501781
74SGK10.73004293
75PLK20.71641629
76TNK20.71061018
77EPHB10.65485569
78CDK30.64907087
79ERBB30.64026653
80AURKA0.62794669
81RAF10.62229763
82ALK0.61432546
83RPS6KL10.59293449
84RPS6KC10.59293449
85WNK40.59160426
86STK110.58995093
87CDK150.58927653
88PRKCZ0.58876906
89PDPK10.57874653
90CHEK20.57477300
91CDK180.57123926
92KSR20.56138060
93CDK120.56107466
94PRKCG0.56056438
95CAMK10.56050386
96CAMK2D0.55880046
97MAPK100.54500554
98CDK11A0.51945343
99PNCK0.51527002
100BRSK10.51308642
101MAP3K20.50935700
102TTK0.50441324
103KSR10.50363776
104EPHB20.50135693
105NME20.49649283
106BRAF0.49337469
107CAMK1D0.48389837
108CAMKK20.47084328
109RET0.46924129
110CDK70.46619897
111CAMK2G0.46155859
112RPS6KA60.45831085
113BMPR20.44806443
114ILK0.44433193
115PRKCH0.43273861
116RPS6KA30.42663647
117CASK0.42282682
118RPS6KB10.41740715
119CAMK40.41736046
120FGFR40.41223601
121LRRK20.40938046
122AKT20.40771418
123CDK140.40736939
124CAMK1G0.40437665
125CDK60.39629392
126HIPK20.39620323
127NTRK10.39554140
128RPS6KB20.39500777
129GSK3B0.38548032
130NEK60.37913005
131PRKAA10.37360179
132SGK30.37263833
133DYRK1B0.36251642
134ROCK20.34167055
135MAP2K40.33330335
136MAPK140.32743044
137MAPK80.32593776
138MAP2K20.32403238
139SGK4940.32171020
140SGK2230.32171020
141MAP3K70.31717798
142SGK20.31676233
143ROCK10.30718797
144GSK3A0.29463674
145IRAK20.27738496
146PIM20.27449083
147PTK2B0.27415871
148IRAK30.27306696
149CDK10.27042235
150CSNK1G20.27006403

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.07567129
2Olfactory transduction_Homo sapiens_hsa047402.32768150
3Glutamatergic synapse_Homo sapiens_hsa047242.21786330
4Long-term potentiation_Homo sapiens_hsa047202.16204480
5Synaptic vesicle cycle_Homo sapiens_hsa047212.13606424
6Circadian entrainment_Homo sapiens_hsa047132.04310151
7Morphine addiction_Homo sapiens_hsa050321.97359773
8Amphetamine addiction_Homo sapiens_hsa050311.96879782
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.93781653
10GABAergic synapse_Homo sapiens_hsa047271.85975420
11Phenylalanine metabolism_Homo sapiens_hsa003601.78718028
12Salivary secretion_Homo sapiens_hsa049701.60866504
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59082688
14Histidine metabolism_Homo sapiens_hsa003401.48654862
15Dopaminergic synapse_Homo sapiens_hsa047281.48486683
16Fatty acid biosynthesis_Homo sapiens_hsa000611.47539403
17Taste transduction_Homo sapiens_hsa047421.44716238
18Insulin secretion_Homo sapiens_hsa049111.44034681
19Sulfur relay system_Homo sapiens_hsa041221.41840299
20Long-term depression_Homo sapiens_hsa047301.40416044
21Cholinergic synapse_Homo sapiens_hsa047251.40313398
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39074300
23ErbB signaling pathway_Homo sapiens_hsa040121.38460113
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36133064
25Vitamin B6 metabolism_Homo sapiens_hsa007501.34785889
26GnRH signaling pathway_Homo sapiens_hsa049121.28230190
27Oxytocin signaling pathway_Homo sapiens_hsa049211.27946799
28Circadian rhythm_Homo sapiens_hsa047101.25297150
29Calcium signaling pathway_Homo sapiens_hsa040201.24722299
30Gastric acid secretion_Homo sapiens_hsa049711.21176613
31Axon guidance_Homo sapiens_hsa043601.20191303
32Serotonergic synapse_Homo sapiens_hsa047261.19083265
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17806398
34Gap junction_Homo sapiens_hsa045401.17668439
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16272550
36Wnt signaling pathway_Homo sapiens_hsa043101.15806388
37Choline metabolism in cancer_Homo sapiens_hsa052311.15318710
38mTOR signaling pathway_Homo sapiens_hsa041501.14550859
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12951238
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11432691
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08173576
42Tyrosine metabolism_Homo sapiens_hsa003501.06806116
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05505040
44Estrogen signaling pathway_Homo sapiens_hsa049151.05166043
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.05112816
46Renin secretion_Homo sapiens_hsa049241.04272405
47Notch signaling pathway_Homo sapiens_hsa043301.02176191
48Dorso-ventral axis formation_Homo sapiens_hsa043201.01564649
49MAPK signaling pathway_Homo sapiens_hsa040101.01422879
50cAMP signaling pathway_Homo sapiens_hsa040241.01065388
51Type II diabetes mellitus_Homo sapiens_hsa049300.99404732
52Oocyte meiosis_Homo sapiens_hsa041140.98472990
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98184223
54Glioma_Homo sapiens_hsa052140.97879250
55Sphingolipid metabolism_Homo sapiens_hsa006000.97722917
56Cocaine addiction_Homo sapiens_hsa050300.96368104
57Phototransduction_Homo sapiens_hsa047440.95337339
58VEGF signaling pathway_Homo sapiens_hsa043700.95203191
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94998489
60AMPK signaling pathway_Homo sapiens_hsa041520.94684159
61Hedgehog signaling pathway_Homo sapiens_hsa043400.94657655
62Fructose and mannose metabolism_Homo sapiens_hsa000510.94454083
63Melanogenesis_Homo sapiens_hsa049160.92791936
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91329764
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.91228800
66mRNA surveillance pathway_Homo sapiens_hsa030150.89598223
67Bile secretion_Homo sapiens_hsa049760.89280317
68Insulin signaling pathway_Homo sapiens_hsa049100.88117816
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.86958526
70Thyroid cancer_Homo sapiens_hsa052160.86893696
71Vibrio cholerae infection_Homo sapiens_hsa051100.85974173
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85690645
73ECM-receptor interaction_Homo sapiens_hsa045120.85681851
74Hippo signaling pathway_Homo sapiens_hsa043900.84048228
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83803967
76Colorectal cancer_Homo sapiens_hsa052100.83209074
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83120778
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.82693841
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81057847
80Bladder cancer_Homo sapiens_hsa052190.79643934
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78098896
82Adherens junction_Homo sapiens_hsa045200.77902286
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.77142376
84Lysine degradation_Homo sapiens_hsa003100.77063070
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.76898385
86Base excision repair_Homo sapiens_hsa034100.76710343
87Fanconi anemia pathway_Homo sapiens_hsa034600.76585241
88Prion diseases_Homo sapiens_hsa050200.75028944
89Rap1 signaling pathway_Homo sapiens_hsa040150.74932135
90Ras signaling pathway_Homo sapiens_hsa040140.74921797
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74735203
92Mismatch repair_Homo sapiens_hsa034300.74677296
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73436740
94Chronic myeloid leukemia_Homo sapiens_hsa052200.73170917
95Endometrial cancer_Homo sapiens_hsa052130.72698592
96beta-Alanine metabolism_Homo sapiens_hsa004100.71392320
97Endocytosis_Homo sapiens_hsa041440.71320611
98Dilated cardiomyopathy_Homo sapiens_hsa054140.70437812
99Focal adhesion_Homo sapiens_hsa045100.68285963
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67428069
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65136691
102Thyroid hormone synthesis_Homo sapiens_hsa049180.64928486
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.64488509
104Chemokine signaling pathway_Homo sapiens_hsa040620.62007658
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61980283
106ABC transporters_Homo sapiens_hsa020100.61357621
107Proteoglycans in cancer_Homo sapiens_hsa052050.61280388
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60035126
109Glucagon signaling pathway_Homo sapiens_hsa049220.59521194
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57652146
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54803202
112MicroRNAs in cancer_Homo sapiens_hsa052060.54236197
113Arginine and proline metabolism_Homo sapiens_hsa003300.53315392
114Collecting duct acid secretion_Homo sapiens_hsa049660.53104153
115Basal cell carcinoma_Homo sapiens_hsa052170.52965180
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.52737898
117Ovarian steroidogenesis_Homo sapiens_hsa049130.52249396
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52133552
119Pancreatic secretion_Homo sapiens_hsa049720.51023032
120Shigellosis_Homo sapiens_hsa051310.49970731
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49532238
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49316866
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48779048
124Tight junction_Homo sapiens_hsa045300.48176419
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46669624
126Salmonella infection_Homo sapiens_hsa051320.45623285
127B cell receptor signaling pathway_Homo sapiens_hsa046620.44972947
128Mineral absorption_Homo sapiens_hsa049780.44899450
129Inositol phosphate metabolism_Homo sapiens_hsa005620.44550581
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42756502
131Non-small cell lung cancer_Homo sapiens_hsa052230.42370229
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41797461
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41366259

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