ARHGAP40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.73990854
2embryonic process involved in female pregnancy (GO:0060136)8.46325217
3proline metabolic process (GO:0006560)8.04033882
4transcription from mitochondrial promoter (GO:0006390)7.52868523
5positive regulation of protein homooligomerization (GO:0032464)7.44169694
6replication fork processing (GO:0031297)7.38552727
7regulation of water loss via skin (GO:0033561)6.81844582
8establishment of skin barrier (GO:0061436)6.79532995
9oxidative demethylation (GO:0070989)6.74928978
10establishment of apical/basal cell polarity (GO:0035089)6.70940948
11regulation of integrin activation (GO:0033623)6.55624486
12regulation of protein homooligomerization (GO:0032462)6.42349901
13bundle of His cell to Purkinje myocyte communication (GO:0086069)6.15574952
14maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.85408947
15establishment or maintenance of monopolar cell polarity (GO:0061339)5.83874215
16establishment of monopolar cell polarity (GO:0061162)5.83874215
17DNA deamination (GO:0045006)5.78781126
18genitalia morphogenesis (GO:0035112)5.50846806
19DNA strand renaturation (GO:0000733)5.31947721
20mitochondrial DNA metabolic process (GO:0032042)5.27951124
21lung epithelium development (GO:0060428)5.21721151
22multicellular organismal water homeostasis (GO:0050891)5.15936383
23poly(A)+ mRNA export from nucleus (GO:0016973)5.04107293
24cellular response to ATP (GO:0071318)4.99791190
25keratinocyte proliferation (GO:0043616)4.95983235
26embryonic placenta development (GO:0001892)4.87149828
27negative regulation of fatty acid biosynthetic process (GO:0045717)4.80032752
28negative regulation of Ras GTPase activity (GO:0034261)4.77601153
29somatic hypermutation of immunoglobulin genes (GO:0016446)4.72135061
30somatic diversification of immune receptors via somatic mutation (GO:0002566)4.72135061
31negative regulation of JAK-STAT cascade (GO:0046426)4.66489154
32mitotic G1 DNA damage checkpoint (GO:0031571)4.64898604
33negative regulation of cell cycle arrest (GO:0071157)4.57023548
34positive regulation of protein oligomerization (GO:0032461)4.45128088
35negative regulation of protein oligomerization (GO:0032460)4.42984000
36embryonic camera-type eye development (GO:0031076)4.37154784
37regulation of glomerular filtration (GO:0003093)4.34296185
38lateral sprouting from an epithelium (GO:0060601)4.33996329
39regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.32952250
40viral mRNA export from host cell nucleus (GO:0046784)4.27655395
41regulation of translational fidelity (GO:0006450)4.25707461
42negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.23608619
43epithelial cell-cell adhesion (GO:0090136)4.23481047
44face development (GO:0060324)4.21746434
45glutamine family amino acid biosynthetic process (GO:0009084)4.20305746
46regulation of protein oligomerization (GO:0032459)4.19941664
47keratinocyte differentiation (GO:0030216)4.19345611
48DNA integration (GO:0015074)4.15885485
49water homeostasis (GO:0030104)4.15242183
50G1 DNA damage checkpoint (GO:0044783)4.14466134
51labyrinthine layer development (GO:0060711)4.13190014
52mitotic G1/S transition checkpoint (GO:0044819)4.09245225
53skin morphogenesis (GO:0043589)4.01239755
54keratinization (GO:0031424)3.95309725
55regulation of cAMP-dependent protein kinase activity (GO:2000479)3.94251262
56hypotonic response (GO:0006971)3.90142035
57convergent extension (GO:0060026)3.89813516
58glial cell migration (GO:0008347)3.88891276
59trophectodermal cell differentiation (GO:0001829)3.88119625
60intestinal epithelial cell development (GO:0060576)3.88102037
61DNA double-strand break processing (GO:0000729)3.87012977
62negative regulation of heart rate (GO:0010459)3.83623986
63positive regulation of circadian rhythm (GO:0042753)3.82455800
64mRNA cleavage (GO:0006379)3.81523988
65signal complex assembly (GO:0007172)3.78888572
66cellular response to zinc ion (GO:0071294)3.78565478
67COPI coating of Golgi vesicle (GO:0048205)3.77498300
68Golgi transport vesicle coating (GO:0048200)3.77498300
69planar cell polarity pathway involved in neural tube closure (GO:0090179)3.73675952
70regulation of podosome assembly (GO:0071801)3.69431360
71regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.69279148
72apoptotic process involved in morphogenesis (GO:0060561)3.69044956
73glomerular basement membrane development (GO:0032836)3.67867067
74hemidesmosome assembly (GO:0031581)3.65664295
75spliceosomal tri-snRNP complex assembly (GO:0000244)3.65446393
76positive regulation of developmental pigmentation (GO:0048087)3.64394955
77anatomical structure regression (GO:0060033)3.64251969
78gap junction assembly (GO:0016264)3.62935078
79establishment of protein localization to mitochondrial membrane (GO:0090151)3.62489186
80negative regulation of T cell differentiation in thymus (GO:0033085)3.60405471
81cytoskeletal anchoring at plasma membrane (GO:0007016)3.60157641
82peptide cross-linking (GO:0018149)3.59709051
83negative regulation of cell fate specification (GO:0009996)3.59525628
84regulation of cardioblast differentiation (GO:0051890)3.59143612
85negative regulation of chondrocyte differentiation (GO:0032331)3.58032849
86embryonic eye morphogenesis (GO:0048048)3.57385523
87positive regulation by host of viral transcription (GO:0043923)3.54799626
88renal system process involved in regulation of blood volume (GO:0001977)3.50813666
89atrioventricular valve morphogenesis (GO:0003181)3.48943453
90regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.46791321
91activation of Rac GTPase activity (GO:0032863)3.45633217
92dosage compensation (GO:0007549)3.44773666
93polarized epithelial cell differentiation (GO:0030859)3.43699897
94formation of translation preinitiation complex (GO:0001731)3.42378778
95regulation of sister chromatid cohesion (GO:0007063)3.41572579
96negative regulation of keratinocyte proliferation (GO:0010839)3.38691900
97branching involved in mammary gland duct morphogenesis (GO:0060444)3.37108148
98base-excision repair (GO:0006284)3.36710215
99negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.35268544
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.33691955
101epidermal cell differentiation (GO:0009913)3.33151895
102keratinocyte development (GO:0003334)3.30640385
103N-glycan processing (GO:0006491)3.29903314
104regulation of cell size (GO:0008361)3.29902929
105double-strand break repair via nonhomologous end joining (GO:0006303)3.28916570
106non-recombinational repair (GO:0000726)3.28916570
107regulation of cholesterol homeostasis (GO:2000188)3.28429338
108histone H4-K12 acetylation (GO:0043983)3.26609061
109protein localization to endosome (GO:0036010)3.26366958
110positive regulation of receptor recycling (GO:0001921)3.26110792
111negative regulation of stress fiber assembly (GO:0051497)3.24843572
112meiotic chromosome segregation (GO:0045132)3.24531039
113endocardial cushion development (GO:0003197)3.23623485
114negative regulation of cartilage development (GO:0061037)3.22364427
115epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.20732459
116sulfur amino acid catabolic process (GO:0000098)3.20683872
117protein targeting to lysosome (GO:0006622)3.20497031
118establishment of protein localization to vacuole (GO:0072666)3.20497031
119protein targeting to vacuole (GO:0006623)3.20497031
120regulation of response to reactive oxygen species (GO:1901031)3.20490579
121L-serine transport (GO:0015825)3.19691945
122regulation of keratinocyte proliferation (GO:0010837)3.18697454
123establishment of planar polarity (GO:0001736)3.18417713
124establishment of tissue polarity (GO:0007164)3.18417713
125positive regulation of DNA repair (GO:0045739)3.18049726
126regulation of mitochondrial depolarization (GO:0051900)3.17955440
127non-canonical Wnt signaling pathway (GO:0035567)3.17699173
128positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.16620597
129positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.16620597
130positive regulation of mitotic sister chromatid separation (GO:1901970)3.16620597
131ectoderm development (GO:0007398)3.10470642
132DNA topological change (GO:0006265)3.10451604
133negative regulation of appetite (GO:0032099)3.09253399
134negative regulation of response to food (GO:0032096)3.09253399
135auditory receptor cell stereocilium organization (GO:0060088)3.09216696
136outflow tract septum morphogenesis (GO:0003148)3.04837716
137phospholipid scrambling (GO:0017121)3.04812662
138DNA demethylation (GO:0080111)3.04694270
139base-excision repair, AP site formation (GO:0006285)3.04398230
140nodal signaling pathway (GO:0038092)3.04112736
141regulation of RNA export from nucleus (GO:0046831)3.01377629
142negative regulation of mRNA processing (GO:0050686)2.99148443
143lung secretory cell differentiation (GO:0061140)2.96449316
144epidermis development (GO:0008544)2.96343240
145embryonic retina morphogenesis in camera-type eye (GO:0060059)2.93501470
146cell migration involved in gastrulation (GO:0042074)2.92321994
147apical protein localization (GO:0045176)2.86241575
148morphogenesis of embryonic epithelium (GO:0016331)2.86057658
149glomerular visceral epithelial cell development (GO:0072015)2.80626095
150Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.80187704
151embryonic foregut morphogenesis (GO:0048617)2.79488115
152organ formation (GO:0048645)2.79062968
153positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.78587126
154endothelial cell chemotaxis (GO:0035767)2.78537708
155maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.74987916
156semaphorin-plexin signaling pathway (GO:0071526)2.72982641
157regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.71994979
158glomerular epithelial cell development (GO:0072310)2.68640813
159regulation of hippo signaling (GO:0035330)2.67959145
160regulation of establishment of planar polarity (GO:0090175)2.67887852
1614-hydroxyproline metabolic process (GO:0019471)2.67770137
162hippo signaling (GO:0035329)2.65699513
163endoderm formation (GO:0001706)2.64853299
164negative regulation of cell fate commitment (GO:0010454)2.64158051
165mesonephros development (GO:0001823)2.62286812
166serine transport (GO:0032329)2.61998963
167response to vitamin A (GO:0033189)2.61620241
168maternal placenta development (GO:0001893)2.60540075
169surfactant homeostasis (GO:0043129)2.60046506
170protein retention in ER lumen (GO:0006621)2.59662097
171insulin-like growth factor receptor signaling pathway (GO:0048009)2.58399454
172organ induction (GO:0001759)2.55009673
173organ growth (GO:0035265)2.53734520
174regulation of interleukin-13 production (GO:0032656)2.53519276
175positive regulation of epidermal cell differentiation (GO:0045606)2.53175986
176regulation of transforming growth factor beta1 production (GO:0032908)2.52938168
177cell-cell junction maintenance (GO:0045217)2.50997915
178RNA localization (GO:0006403)2.50536696
179columnar/cuboidal epithelial cell development (GO:0002066)2.48909712
180positive regulation of adherens junction organization (GO:1903393)2.47744960
181regulation of keratinocyte differentiation (GO:0045616)2.47424703
182chemical homeostasis within a tissue (GO:0048875)2.45558499
183cell-cell junction assembly (GO:0007043)2.45143343
184positive regulation of epidermis development (GO:0045684)2.44975561
185cell junction maintenance (GO:0034331)2.43486404
186dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.42834974
187retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.41696890
188fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.41387550
189regulation of mesoderm development (GO:2000380)2.41318942
190bone morphogenesis (GO:0060349)2.40279826
191epithelial cell fate commitment (GO:0072148)2.39846522
192proline biosynthetic process (GO:0006561)10.4275360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human5.00657079
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.61829396
3ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.51503793
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.32482794
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.17760897
6SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.13663393
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.05961881
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.05961881
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.05961881
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.87335834
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.75335275
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.72861336
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.68706723
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.62134181
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.60894786
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.50072335
17NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.38481592
18* LXR_22292898_ChIP-Seq_THP-1_Human2.35047710
19POU5F1_16518401_ChIP-PET_MESCs_Mouse2.21807583
20TCF3_18692474_ChIP-Seq_MESCs_Mouse2.21254513
21KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.20199735
22ZNF217_24962896_ChIP-Seq_MCF-7_Human2.12461079
23VDR_21846776_ChIP-Seq_THP-1_Human2.10689547
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09781629
25DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.05152513
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.01838400
27ZNF263_19887448_ChIP-Seq_K562_Human1.96391754
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.95240432
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.94375054
30* RACK7_27058665_Chip-Seq_MCF-7_Human1.90331935
31* GATA3_24758297_ChIP-Seq_MCF-7_Human1.90265367
32CLOCK_20551151_ChIP-Seq_293T_Human1.88747148
33GATA6_25053715_ChIP-Seq_YYC3_Human1.88744956
34AR_21909140_ChIP-Seq_LNCAP_Human1.84295488
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.83193274
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.81806908
37TCF3_18692474_ChIP-Seq_MEFs_Mouse1.80280156
38* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.80187645
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.76857937
40SOX9_24532713_ChIP-Seq_HFSC_Mouse1.76270597
41EOMES_21245162_ChIP-Seq_HESCs_Human1.76008201
42PU.1_20513432_ChIP-Seq_Bcells_Mouse1.75566924
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.72273922
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.72273922
45NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.71402357
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.69549939
47GATA4_25053715_ChIP-Seq_YYC3_Human1.68909189
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68173518
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66183959
50CDX2_20551321_ChIP-Seq_CACO-2_Human1.63561488
51KLF5_25053715_ChIP-Seq_YYC3_Human1.61777325
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.61563545
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.59905173
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.58493800
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.56314704
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.54255372
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54021615
58TP53_20018659_ChIP-ChIP_R1E_Mouse1.52285444
59ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.49486143
60PPAR_26484153_Chip-Seq_NCI-H1993_Human1.49355700
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.49076329
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.49012869
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46963487
64TRIM28_21343339_ChIP-Seq_HEK293_Human1.46904025
65RXR_22158963_ChIP-Seq_LIVER_Mouse1.46498261
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46269683
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45954014
68RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.44778695
69SOX2_20726797_ChIP-Seq_SW620_Human1.43497453
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43037801
71PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.42390719
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42285913
73NANOG_18692474_ChIP-Seq_MESCs_Mouse1.40514420
74SMAD3_21741376_ChIP-Seq_HESCs_Human1.37689761
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35409869
76ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.34264276
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.33318631
78TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31326485
79* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.30856542
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30775813
81SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30211833
82KDM2B_26808549_Chip-Seq_DND41_Human1.29670170
83MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28494524
84POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.27863832
85NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.27603181
86KDM2B_26808549_Chip-Seq_K562_Human1.26902343
87FOXA2_19822575_ChIP-Seq_HepG2_Human1.26437388
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.25299767
89* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25112580
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24203417
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22880849
92SALL1_21062744_ChIP-ChIP_HESCs_Human1.22568566
93SPI1_26923725_Chip-Seq_HPCs_Mouse1.22221601
94RARB_24833708_ChIP-Seq_LIVER_Mouse1.22192167
95AHR_22903824_ChIP-Seq_MCF-7_Human1.21691438
96ETS1_21867929_ChIP-Seq_TH2_Mouse1.21228665
97CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20918110
98P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19952123
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19360894
100RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19354561
101MYC_18555785_ChIP-Seq_MESCs_Mouse1.18374970
102ELF5_23300383_ChIP-Seq_T47D_Human1.17800399
103FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16895806
104CTCF_27219007_Chip-Seq_Bcells_Human1.16682273
105TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.16435755
106SOX2_18692474_ChIP-Seq_MESCs_Mouse1.16050497
107CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15967274
108KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15589738
109ESR1_21235772_ChIP-Seq_MCF-7_Human1.15387236
110KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15108634
111E2F1_20622854_ChIP-Seq_HELA_Human1.15022949
112STAT1_20625510_ChIP-Seq_HELA_Human1.15015381
113BCOR_27268052_Chip-Seq_Bcells_Human1.14764579
114RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14496608
115RING1B_27294783_Chip-Seq_NPCs_Mouse1.14484199
116NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12977953
117NANOG_16518401_ChIP-PET_MESCs_Mouse1.12408591
118TP63_22573176_ChIP-Seq_HFKS_Human1.11717009
119EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09842559
120STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09312100
121RUNX1_27514584_Chip-Seq_MCF-7_Human1.08869722
122ELK3_25401928_ChIP-Seq_HUVEC_Human1.08722532
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08319473
124* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.08285553
125NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07653586
126SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07454288
127HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07321154
128PHF8_20622854_ChIP-Seq_HELA_Human1.07232436
129SA1_27219007_Chip-Seq_ERYTHROID_Human1.06831206
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04871204
131CREB1_26743006_Chip-Seq_LNCaP_Human1.04740981
132FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.04531650
133POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04154801
134NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04062764
135RARA_24833708_ChIP-Seq_LIVER_Mouse1.03981829
136SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99958270
137ATF3_27146783_Chip-Seq_COLON_Human0.99854567
138FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98912248
139P68_20966046_ChIP-Seq_HELA_Human0.98229966
140SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96185626
141KDM2B_26808549_Chip-Seq_JURKAT_Human0.95671582
142NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95659692
143CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95182840
144TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95111742
145BCL6_27268052_Chip-Seq_Bcells_Human0.94951193
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.94902808
147ARNT_22903824_ChIP-Seq_MCF-7_Human0.94841800
148PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94520009
149NANOG_18692474_ChIP-Seq_MEFs_Mouse0.94004897
150OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93038950
151STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92788305
152YY1_22570637_ChIP-Seq_MALME-3M_Human0.92662928
153FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92342313
154STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.91259780
155GATA2_21666600_ChIP-Seq_HMVEC_Human0.90286084
156LXR_22158963_ChIP-Seq_LIVER_Mouse0.90140334
157SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89117827
158SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89021164
159TET1_21490601_ChIP-Seq_MESCs_Mouse0.87010290
160MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86597726
161ISL1_27105846_Chip-Seq_CPCs_Mouse0.86330663

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.54399576
2MP0010030_abnormal_orbit_morphology4.27592129
3MP0005171_absent_coat_pigmentation4.26940585
4MP0002796_impaired_skin_barrier4.17028339
5MP0005377_hearing/vestibular/ear_phenot3.95871063
6MP0003878_abnormal_ear_physiology3.95871063
7MP0009278_abnormal_bone_marrow3.81739041
8MP0002009_preneoplasia3.65662915
9MP0000579_abnormal_nail_morphology3.52893882
10MP0004233_abnormal_muscle_weight3.35727217
11MP0003283_abnormal_digestive_organ3.14187156
12MP0005257_abnormal_intraocular_pressure3.08671790
13MP0000566_synostosis3.07285383
14MP0003453_abnormal_keratinocyte_physiol2.85960794
15MP0005501_abnormal_skin_physiology2.65109468
16MP0002132_abnormal_respiratory_system2.61122810
17MP0002060_abnormal_skin_morphology2.36397310
18MP0008995_early_reproductive_senescence2.33383614
19MP0003941_abnormal_skin_development2.13892143
20MP0006072_abnormal_retinal_apoptosis2.12345422
21MP0004272_abnormal_basement_membrane2.05345857
22MP0003890_abnormal_embryonic-extraembry2.04496795
23MP0000762_abnormal_tongue_morphology2.00670162
24MP0010678_abnormal_skin_adnexa1.97773981
25MP0003191_abnormal_cellular_cholesterol1.97758779
26MP0002249_abnormal_larynx_morphology1.97322345
27MP0003119_abnormal_digestive_system1.97230487
28MP0005275_abnormal_skin_tensile1.92508726
29MP0002282_abnormal_trachea_morphology1.86614759
30MP0000467_abnormal_esophagus_morphology1.86206968
31MP0006054_spinal_hemorrhage1.86010340
32MP0001545_abnormal_hematopoietic_system1.84541233
33MP0005397_hematopoietic_system_phenotyp1.84541233
34MP0005083_abnormal_biliary_tract1.75363231
35MP0005076_abnormal_cell_differentiation1.74223986
36MP0004133_heterotaxia1.71952203
37MP0000462_abnormal_digestive_system1.69999827
38MP0005174_abnormal_tail_pigmentation1.64242220
39MP0004264_abnormal_extraembryonic_tissu1.64034854
40MP0010352_gastrointestinal_tract_polyps1.63459913
41MP0003786_premature_aging1.57217105
42MP0000470_abnormal_stomach_morphology1.55591027
43MP0000383_abnormal_hair_follicle1.55520256
44MP0000627_abnormal_mammary_gland1.45697525
45MP0009780_abnormal_chondrocyte_physiolo1.45573468
46MP0009384_cardiac_valve_regurgitation1.45062977
47MP0001340_abnormal_eyelid_morphology1.42526128
48MP0010234_abnormal_vibrissa_follicle1.41486123
49MP0002086_abnormal_extraembryonic_tissu1.39533038
50MP0002653_abnormal_ependyma_morphology1.39238315
51MP0010771_integument_phenotype1.37224306
52MP0003045_fibrosis1.34042423
53MP0004782_abnormal_surfactant_physiolog1.33667757
54MP0003566_abnormal_cell_adhesion1.32351020
55MP0005409_darkened_coat_color1.30599046
56MP0002084_abnormal_developmental_patter1.30375161
57MP0003705_abnormal_hypodermis_morpholog1.27612658
58MP0004197_abnormal_fetal_growth/weight/1.26692934
59MP0002111_abnormal_tail_morphology1.26619481
60MP0008004_abnormal_stomach_pH1.23511096
61MP0005367_renal/urinary_system_phenotyp1.18384813
62MP0000516_abnormal_urinary_system1.18384813
63MP0002269_muscular_atrophy1.17279575
64MP0001293_anophthalmia1.17134442
65MP0000678_abnormal_parathyroid_gland1.16107267
66MP0010094_abnormal_chromosome_stability1.16075998
67MP0003755_abnormal_palate_morphology1.15962421
68MP0000377_abnormal_hair_follicle1.11796241
69MP0002085_abnormal_embryonic_tissue1.09392230
70MP0002098_abnormal_vibrissa_morphology1.08754620
71MP0001697_abnormal_embryo_size1.08392887
72MP0001216_abnormal_epidermal_layer1.07479809
73MP0005645_abnormal_hypothalamus_physiol1.04817207
74MP0000015_abnormal_ear_pigmentation1.04653703
75MP0003937_abnormal_limbs/digits/tail_de1.03647046
76MP0003936_abnormal_reproductive_system1.03045542
77MP0005248_abnormal_Harderian_gland1.02920567
78MP0003115_abnormal_respiratory_system1.02505970
79MP0003567_abnormal_fetal_cardiomyocyte1.01981018
80MP0004885_abnormal_endolymph1.01977568
81MP0004957_abnormal_blastocyst_morpholog1.00156437
82MP0005394_taste/olfaction_phenotype0.99291462
83MP0005499_abnormal_olfactory_system0.99291462
84MP0004185_abnormal_adipocyte_glucose0.98587062
85MP0000371_diluted_coat_color0.97915933
86MP0000537_abnormal_urethra_morphology0.96846161
87MP0005058_abnormal_lysosome_morphology0.96576832
88MP0000490_abnormal_crypts_of0.96551639
89MP0005075_abnormal_melanosome_morpholog0.95482920
90MP0009053_abnormal_anal_canal0.94536092
91MP0005408_hypopigmentation0.94511517
92MP0002932_abnormal_joint_morphology0.94073574
93MP0003172_abnormal_lysosome_physiology0.92716126
94MP0003935_abnormal_craniofacial_develop0.91581491
95MP0002697_abnormal_eye_size0.91460059
96MP0004019_abnormal_vitamin_homeostasis0.91269373
97MP0005451_abnormal_body_composition0.90209799
98MP0001346_abnormal_lacrimal_gland0.89416487
99MP0001661_extended_life_span0.89227438
100MP0008058_abnormal_DNA_repair0.86328971
101MP0003943_abnormal_hepatobiliary_system0.86204813
102MP0009115_abnormal_fat_cell0.85930788
103MP0001849_ear_inflammation0.85562030
104MP0003942_abnormal_urinary_system0.84734917
105MP0000647_abnormal_sebaceous_gland0.84646164
106MP0000367_abnormal_coat/_hair0.84475326
107MP0000639_abnormal_adrenal_gland0.84423641
108MP0002277_abnormal_respiratory_mucosa0.83624998
109MP0005085_abnormal_gallbladder_physiolo0.82603933
110MP0009931_abnormal_skin_appearance0.81213515
111MP0001672_abnormal_embryogenesis/_devel0.80830917
112MP0005380_embryogenesis_phenotype0.80830917
113MP0001666_abnormal_nutrient_absorption0.80138879
114MP0005508_abnormal_skeleton_morphology0.79248589
115MP0002114_abnormal_axial_skeleton0.78903784
116MP0000534_abnormal_ureter_morphology0.78478142
117MP0008932_abnormal_embryonic_tissue0.77886485
118MP0002233_abnormal_nose_morphology0.77179878
119MP0005023_abnormal_wound_healing0.77082194
120MP0000432_abnormal_head_morphology0.76852858
121MP0002116_abnormal_craniofacial_bone0.76806830
122MP0003137_abnormal_impulse_conducting0.76482220
123MP0002254_reproductive_system_inflammat0.75607564
124MP0002089_abnormal_postnatal_growth/wei0.74558221
125MP0009672_abnormal_birth_weight0.74494320
126MP0008877_abnormal_DNA_methylation0.74450067
127MP0001784_abnormal_fluid_regulation0.73598714
128MP0001881_abnormal_mammary_gland0.73048389
129MP0000767_abnormal_smooth_muscle0.71318348
130MP0002332_abnormal_exercise_endurance0.69906675
131MP0005330_cardiomyopathy0.69579307
132MP0000049_abnormal_middle_ear0.69553798
133MP0000350_abnormal_cell_proliferation0.68004491
134MP0003828_pulmonary_edema0.67606013
135MP0003385_abnormal_body_wall0.64416738
136MP0000428_abnormal_craniofacial_morphol0.64144430
137MP0004043_abnormal_pH_regulation0.63844185
138MP0010368_abnormal_lymphatic_system0.63410505
139MP0002108_abnormal_muscle_morphology0.62835298
140MP0002925_abnormal_cardiovascular_devel0.62544621
141MP0003984_embryonic_growth_retardation0.62330142
142MP0001324_abnormal_eye_pigmentation0.61826288
143MP0001186_pigmentation_phenotype0.61575936
144MP0004381_abnormal_hair_follicle0.61302656
145MP0004134_abnormal_chest_morphology0.61095419
146MP0002088_abnormal_embryonic_growth/wei0.60874708
147MP0002019_abnormal_tumor_incidence0.59841019
148MP0005266_abnormal_metabolism0.58161755
149MP0010630_abnormal_cardiac_muscle0.58004776
150MP0001286_abnormal_eye_development0.57294308
151MP0002896_abnormal_bone_mineralization0.57261685
152MP0005365_abnormal_bile_salt0.57041079
153MP0000751_myopathy0.54995549

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.64874190
2Alopecia of scalp (HP:0002293)5.63414673
3Concave nail (HP:0001598)5.44102513
4Pustule (HP:0200039)5.13156423
5Annular pancreas (HP:0001734)4.99016179
6Hypochromic microcytic anemia (HP:0004840)4.89391147
7Rib fusion (HP:0000902)4.88732781
8Hypotrichosis (HP:0001006)4.75503321
9Turricephaly (HP:0000262)4.60153954
10Ulnar bowing (HP:0003031)4.55825187
11Abnormality of nail color (HP:0100643)4.54951624
12Facial hemangioma (HP:0000329)4.41764092
13Coronal craniosynostosis (HP:0004440)4.30624539
14Poikiloderma (HP:0001029)4.13097706
15Rectal fistula (HP:0100590)4.03836501
16Rectovaginal fistula (HP:0000143)4.03836501
17Increased IgM level (HP:0003496)4.01202500
18Aplasia involving bones of the upper limbs (HP:0009823)3.98155737
19Aplasia of the phalanges of the hand (HP:0009802)3.98155737
20Aplasia involving bones of the extremities (HP:0009825)3.98155737
21Congenital ichthyosiform erythroderma (HP:0007431)3.93437232
22Vaginal fistula (HP:0004320)3.87920555
23Abnormal hemoglobin (HP:0011902)3.69182051
24Intestinal fistula (HP:0100819)3.62206899
25Alacrima (HP:0000522)3.60646015
26Palmoplantar hyperkeratosis (HP:0000972)3.52033431
27Abnormality of the dental root (HP:0006486)3.48449924
28Taurodontia (HP:0000679)3.48449924
29Abnormality of permanent molar morphology (HP:0011071)3.48449924
30Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.47024785
31Tongue fasciculations (HP:0001308)3.42199294
32Short humerus (HP:0005792)3.40645462
33Abnormality of the salivary glands (HP:0010286)3.39064408
34Nasolacrimal duct obstruction (HP:0000579)3.36237419
35Abnormality of the dental pulp (HP:0006479)3.35927650
36Male infertility (HP:0003251)3.35739734
37Plantar hyperkeratosis (HP:0007556)3.33059998
38Palmar hyperkeratosis (HP:0010765)3.30086783
39Abnormality of molar (HP:0011077)3.20043479
40Abnormality of molar morphology (HP:0011070)3.20043479
41Intestinal atresia (HP:0011100)3.17397424
42Aplasia/hypoplasia of the humerus (HP:0006507)3.16499366
43Flat acetabular roof (HP:0003180)3.16285362
44Muscle fibrillation (HP:0010546)3.14022372
45Partial duplication of thumb phalanx (HP:0009944)3.11700448
46Orthostatic hypotension (HP:0001278)3.08228920
47Congenital hip dislocation (HP:0001374)3.07104272
48Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.05663017
49Vertebral hypoplasia (HP:0008417)3.05663017
50Anteriorly placed anus (HP:0001545)3.03256140
51Abnormality of the lacrimal duct (HP:0011481)3.03103284
52Abnormality of the distal phalanges of the toes (HP:0010182)3.02155136
53Pili torti (HP:0003777)3.00032768
54Squamous cell carcinoma (HP:0002860)2.99084739
55Hamartoma (HP:0010566)2.95680245
56Short chin (HP:0000331)2.94998956
57Cerebral aneurysm (HP:0004944)2.89199240
58Popliteal pterygium (HP:0009756)2.87353152
59Erythroderma (HP:0001019)2.87252538
60Premature skin wrinkling (HP:0100678)2.85955959
61Decreased lacrimation (HP:0000633)2.83066527
62Choanal stenosis (HP:0000452)2.83014433
63Ependymoma (HP:0002888)2.82727087
64Glomerulonephritis (HP:0000099)2.82457406
65Abnormality of male internal genitalia (HP:0000022)2.82272537
66Large for gestational age (HP:0001520)2.80083366
67Abnormality of the aortic arch (HP:0012303)2.79797865
68Absent radius (HP:0003974)2.78116188
69Diaphragmatic weakness (HP:0009113)2.75056442
70Urinary glycosaminoglycan excretion (HP:0003541)2.73669050
71Mucopolysacchariduria (HP:0008155)2.73669050
72Broad alveolar ridges (HP:0000187)2.73620105
73Partial duplication of the phalanx of hand (HP:0009999)2.72781740
74Redundant skin (HP:0001582)2.69616139
75Nail dystrophy (HP:0008404)2.67697910
76Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.65622090
77Bifid uvula (HP:0000193)2.64991027
78Aplasia involving forearm bones (HP:0009822)2.61532967
79Absent forearm bone (HP:0003953)2.61532967
80Dysautonomia (HP:0002459)2.60051465
81Abnormality of the nasolacrimal system (HP:0000614)2.58889768
82Bowing of the arm (HP:0006488)2.56092177
83Bowed forearm bones (HP:0003956)2.56092177
84Abnormal hair laboratory examination (HP:0003328)2.55769545
85Deep venous thrombosis (HP:0002625)2.55092573
86Fragile nails (HP:0001808)2.52832891
87Dysostosis multiplex (HP:0000943)2.50467717
88Amelogenesis imperfecta (HP:0000705)2.49543263
89Sparse eyelashes (HP:0000653)2.49099487
90Clumsiness (HP:0002312)2.48742673
91Abnormality of polysaccharide metabolism (HP:0011012)2.47669753
92Abnormality of glycosaminoglycan metabolism (HP:0004371)2.47669753
93Abnormality of mucopolysaccharide metabolism (HP:0011020)2.47669753
94Hypochromic anemia (HP:0001931)2.45085239
95Aplasia of the musculature (HP:0100854)2.43269907
96Growth hormone excess (HP:0000845)2.41242363
97Joint stiffness (HP:0001387)2.39234720
98Selective tooth agenesis (HP:0001592)2.39158296
99Pancreatic islet-cell hyperplasia (HP:0004510)2.36217142
100Recurrent corneal erosions (HP:0000495)2.35183987
101Short nail (HP:0001799)2.29942225
102Absent thumb (HP:0009777)2.29923178
103Conical tooth (HP:0000698)2.29387270
104Mixed hearing impairment (HP:0000410)2.26455660
105Volvulus (HP:0002580)2.26235126
106Hypoplasia of the ulna (HP:0003022)2.25745241
107Basal cell carcinoma (HP:0002671)2.25551873
108Lip pit (HP:0100267)2.25220745
109Hyperactive renin-angiotensin system (HP:0000841)2.23942483
110Increased number of teeth (HP:0011069)2.22492433
111Bulbar palsy (HP:0001283)2.20783381
112Hypotelorism (HP:0000601)2.19578738
113Hypokinesia (HP:0002375)2.19492320
114Split hand (HP:0001171)2.19428374
115Gastrointestinal atresia (HP:0002589)2.18999231
116Abnormality of the nasal septum (HP:0000419)2.18151611
117Advanced eruption of teeth (HP:0006288)2.16147856
118Vascular calcification (HP:0004934)2.15761114
119Albinism (HP:0001022)2.14879282
120Narrow nasal bridge (HP:0000446)2.14849639
121Abnormal tarsal ossification (HP:0008369)2.13153258
122Small epiphyses (HP:0010585)2.12335200
123Milia (HP:0001056)2.11235575
124Pterygium (HP:0001059)2.11120051
125Absent eyelashes (HP:0000561)2.09601271
126Hypoplasia of dental enamel (HP:0006297)2.05015450
127Hyperkalemia (HP:0002153)2.03585136
128Anal stenosis (HP:0002025)2.02594679
129Polycythemia (HP:0001901)2.02191470
130Septate vagina (HP:0001153)2.00871007
131Nephritis (HP:0000123)2.00675896
132Sparse lateral eyebrow (HP:0005338)1.99872419
133Onycholysis (HP:0001806)1.98599538
134Renal salt wasting (HP:0000127)1.98195879
135Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98004263
136Abnormality of the astrocytes (HP:0100707)1.97632181
137Astrocytoma (HP:0009592)1.97632181
138Abnormality of the labia minora (HP:0012880)1.97504800
139Ectropion (HP:0000656)1.97476964
140Exercise-induced myalgia (HP:0003738)1.97148456
141Bilateral sensorineural hearing impairment (HP:0008619)1.96773925
142IgA deficiency (HP:0002720)1.96742461
143Hypercortisolism (HP:0001578)1.96698083
144Neonatal death (HP:0003811)1.94167954
145Woolly hair (HP:0002224)1.92827353
146Corneal erosion (HP:0200020)1.92381529
147Natal tooth (HP:0000695)1.91405795
148Vertebral fusion (HP:0002948)1.90829925
149Abnormal vertebral ossification (HP:0100569)1.90294837
150Thick nail (HP:0001805)1.90257157
151Deviation of the thumb (HP:0009603)1.89992916
152Median cleft lip (HP:0000161)1.89661086
153Abnormality of the axillary hair (HP:0100134)1.88111637
154Abnormality of secondary sexual hair (HP:0009888)1.88111637
155Hypohidrosis (HP:0000966)1.87010598
156Cheilitis (HP:0100825)1.86599575
157Atrophic scars (HP:0001075)1.85202649
158Diminished movement (HP:0002374)1.84527267
159Erythema (HP:0010783)1.84271312
160Parakeratosis (HP:0001036)1.83964854
161Capillary hemangiomas (HP:0005306)1.82843204
162Epiphyseal dysplasia (HP:0002656)1.82339398
163Abnormality of carpal bone ossification (HP:0006257)1.82270476
164Abnormality of incisor morphology (HP:0011063)1.81772410
165Hypoplastic labia majora (HP:0000059)1.80707744
166Broad face (HP:0000283)1.80221707
167Arterial tortuosity (HP:0005116)1.78199409
168Limited elbow extension (HP:0001377)1.77906469
169Premature graying of hair (HP:0002216)1.77535144
170Skin pits (HP:0100276)1.77174642
171Patellar aplasia (HP:0006443)1.76858385
172Cardiovascular calcification (HP:0011915)1.76107458
173Increased IgE level (HP:0003212)1.75878532
174Ankyloglossia (HP:0010296)1.73637415
175Osteoarthritis (HP:0002758)1.71490085
176Hyponatremia (HP:0002902)1.71353515
177Broad toe (HP:0001837)1.71256225
178Oral leukoplakia (HP:0002745)1.69640231
179Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.68779432
180Absent epiphyses (HP:0010577)1.68779432
181Curly hair (HP:0002212)1.68497125
182Brittle hair (HP:0002299)1.68333021

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.94406324
2DDR25.36083901
3MAP3K64.95194147
4MAPK154.11470020
5MAP3K113.42548364
6CDK123.32349090
7FGR3.23986343
8PINK13.14773130
9TYRO33.12768614
10MATK3.05985576
11PKN22.88623778
12BMX2.41784178
13DAPK12.36648470
14PDGFRA2.25659561
15TESK12.25028754
16PRKD22.24521779
17UHMK12.19744012
18DYRK1B2.07764269
19CSK2.06717585
20PIM22.02631875
21YES12.00348819
22FGFR41.97816117
23LATS21.92305992
24ERBB21.86438976
25PAK41.86276414
26TRPM71.84994904
27EPHA21.81392740
28PBK1.73965739
29ERBB41.67747355
30SIK31.58348482
31AKT31.48913279
32CDK71.41779336
33PRPF4B1.40191658
34PHKG21.39571723
35PHKG11.39571723
36TRIM281.38933457
37CDK61.30807223
38CDC42BPA1.20699409
39NTRK11.18561516
40STK101.18424012
41TAF11.15981713
42GSK3A1.13367866
43SMG11.10695745
44TGFBR21.09043594
45RPS6KC11.07677686
46RPS6KL11.07677686
47TNIK1.07656590
48MAP3K121.07536618
49LATS11.05021230
50PIM11.02961364
51MAPK110.99087056
52TRIB30.95778432
53BRSK20.95465157
54TAOK20.95328499
55PTK60.94024605
56TGFBR10.93677009
57EPHB10.93250169
58EIF2AK10.93122432
59NME10.91219295
60RPS6KA60.88952375
61FLT30.87247071
62ERBB30.86425549
63ACVR1B0.84872187
64EEF2K0.78908182
65RPS6KB20.78393342
66BRD40.78236776
67HIPK20.70564189
68LRRK20.70234261
69RIPK10.70029454
70FGFR30.69192660
71BCR0.67041434
72RET0.66553506
73CHEK20.65917901
74ERN10.64396474
75MAP2K60.64122981
76PLK40.63782472
77MTOR0.63181472
78RPS6KA10.61803634
79CAMK2B0.58666787
80PRKAA10.58475780
81BMPR1B0.57546756
82PDGFRB0.56881402
83MAP3K130.56251821
84DYRK30.53702863
85STK38L0.52596014
86CAMK2G0.52493230
87TAOK10.50655675
88PTK20.49844377
89WEE10.49824370
90NME20.49540690
91BRSK10.49077759
92MAPKAPK30.48875121
93MST40.48048057
94STK390.47225631
95TNK20.47036139
96STK240.46065257
97EGFR0.45612156
98MAP3K100.43942416
99STK380.43681385
100NEK20.43628036
101NEK60.42795965
102PLK10.42164576
103STK30.42057728
104ARAF0.41639070
105CSNK1G10.41370059
106NLK0.41103531
107FGFR10.39820832
108DMPK0.38831335
109PRKAA20.36706474
110MARK20.36266737
111PRKG20.35967993
112MAP3K30.35639320
113MAP3K20.35323462
114MELK0.35158150
115PRKD30.33610393
116MAPK30.33252828
117CAMK1G0.32742638
118FER0.32643415
119MAP3K90.32193831
120CAMK2D0.32055976
121EIF2AK20.31451707
122MAPKAPK20.31364161
123RAF10.31147608
124ATR0.30254572
125RPS6KB10.29997746
126CAMK1D0.29740497
127LMTK20.29675721
128SGK10.29637035
129MAPK10.29562723
130MAPK40.29269885
131MST1R0.28036643
132CAMK2A0.27699095
133IGF1R0.27631629
134CSNK2A10.27093760
135FGFR20.26631415
136MAPK100.25745941
137CDK20.24995272
138NEK10.24827267
139INSR0.24091063
140MAP2K10.24072224
141MAP3K80.24037002
142CHUK0.23983449
143MAPK140.23921204
144PRKD10.23734217
145LYN0.23625787
146TTK0.23163608
147DYRK20.22971213
148PRKCZ0.21384493
149PAK20.21366757
150TTN0.21278309
151MET0.20171642
152NTRK20.18721337
153ALK0.18593722
154PIK3CG0.17063956
155ABL10.14835392
156RPS6KA30.14693399
157AURKA0.13563465
158PRKCI0.11569187
159SIK10.11520048
160CSNK2A20.11490718
161ATM0.11432525

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.80557049
2Mismatch repair_Homo sapiens_hsa034303.77302662
3Base excision repair_Homo sapiens_hsa034103.74520238
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.88639992
5Circadian rhythm_Homo sapiens_hsa047102.66356766
6ECM-receptor interaction_Homo sapiens_hsa045122.60588215
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.58131141
8Hippo signaling pathway_Homo sapiens_hsa043902.54586144
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.47076015
10Hedgehog signaling pathway_Homo sapiens_hsa043402.46004328
11Adherens junction_Homo sapiens_hsa045202.43032505
12mTOR signaling pathway_Homo sapiens_hsa041502.16798031
13DNA replication_Homo sapiens_hsa030302.14333154
14Notch signaling pathway_Homo sapiens_hsa043302.11347375
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02481216
16Other glycan degradation_Homo sapiens_hsa005111.89540027
17Arginine and proline metabolism_Homo sapiens_hsa003301.84827093
18Bladder cancer_Homo sapiens_hsa052191.84292238
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.75764331
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.74406698
21Phenylalanine metabolism_Homo sapiens_hsa003601.73846360
22Sphingolipid metabolism_Homo sapiens_hsa006001.72131169
23Histidine metabolism_Homo sapiens_hsa003401.67877688
24Fatty acid metabolism_Homo sapiens_hsa012121.58985458
25Basal cell carcinoma_Homo sapiens_hsa052171.58487932
26p53 signaling pathway_Homo sapiens_hsa041151.55302708
27Longevity regulating pathway - mammal_Homo sapiens_hsa042111.53837238
28Amoebiasis_Homo sapiens_hsa051461.51392559
29Wnt signaling pathway_Homo sapiens_hsa043101.50482475
30TGF-beta signaling pathway_Homo sapiens_hsa043501.49861431
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.49666301
32Tight junction_Homo sapiens_hsa045301.46523328
33mRNA surveillance pathway_Homo sapiens_hsa030151.46100282
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42469088
35VEGF signaling pathway_Homo sapiens_hsa043701.38884030
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36597473
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.36114376
38Inositol phosphate metabolism_Homo sapiens_hsa005621.32109721
39Shigellosis_Homo sapiens_hsa051311.29794728
40Nucleotide excision repair_Homo sapiens_hsa034201.27428724
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22671851
42Biosynthesis of amino acids_Homo sapiens_hsa012301.22309444
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.20504217
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18570849
45Complement and coagulation cascades_Homo sapiens_hsa046101.14922558
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14886966
47N-Glycan biosynthesis_Homo sapiens_hsa005101.13508193
48Lysine degradation_Homo sapiens_hsa003101.05951292
49Pancreatic cancer_Homo sapiens_hsa052121.05137138
50Regulation of actin cytoskeleton_Homo sapiens_hsa048101.04482978
51Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03156657
52Sulfur relay system_Homo sapiens_hsa041221.02727605
53RNA transport_Homo sapiens_hsa030131.02531359
54Fanconi anemia pathway_Homo sapiens_hsa034601.01417537
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99649570
56Axon guidance_Homo sapiens_hsa043600.96141800
57Nitrogen metabolism_Homo sapiens_hsa009100.96060291
58Tyrosine metabolism_Homo sapiens_hsa003500.95995481
59Dorso-ventral axis formation_Homo sapiens_hsa043200.94191425
60ErbB signaling pathway_Homo sapiens_hsa040120.93446379
61Gap junction_Homo sapiens_hsa045400.90193128
62Spliceosome_Homo sapiens_hsa030400.90155163
63MicroRNAs in cancer_Homo sapiens_hsa052060.89581070
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.89411437
65Ovarian steroidogenesis_Homo sapiens_hsa049130.84736781
66Arginine biosynthesis_Homo sapiens_hsa002200.84131092
67Colorectal cancer_Homo sapiens_hsa052100.81571444
68Folate biosynthesis_Homo sapiens_hsa007900.81422462
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81286600
70Mineral absorption_Homo sapiens_hsa049780.80828880
71Oocyte meiosis_Homo sapiens_hsa041140.78266713
72Protein digestion and absorption_Homo sapiens_hsa049740.77585099
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77131745
74Homologous recombination_Homo sapiens_hsa034400.75877941
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74393910
76Vitamin digestion and absorption_Homo sapiens_hsa049770.73661155
77Choline metabolism in cancer_Homo sapiens_hsa052310.72829226
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72223533
79Proteoglycans in cancer_Homo sapiens_hsa052050.71559612
80Steroid biosynthesis_Homo sapiens_hsa001000.71364312
81Small cell lung cancer_Homo sapiens_hsa052220.70952094
82PPAR signaling pathway_Homo sapiens_hsa033200.70436000
83Endometrial cancer_Homo sapiens_hsa052130.70268449
84AMPK signaling pathway_Homo sapiens_hsa041520.69858959
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68841120
86Fructose and mannose metabolism_Homo sapiens_hsa000510.68478054
87Glutathione metabolism_Homo sapiens_hsa004800.68157517
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68098417
89Insulin signaling pathway_Homo sapiens_hsa049100.64505735
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.63663918
91Vibrio cholerae infection_Homo sapiens_hsa051100.62702190
92Focal adhesion_Homo sapiens_hsa045100.62342965
93HIF-1 signaling pathway_Homo sapiens_hsa040660.60650522
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59091164
95Non-small cell lung cancer_Homo sapiens_hsa052230.58876309
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57704276
97Thyroid cancer_Homo sapiens_hsa052160.57663739
98Glucagon signaling pathway_Homo sapiens_hsa049220.56518804
99Insulin resistance_Homo sapiens_hsa049310.55826053
100Thyroid hormone synthesis_Homo sapiens_hsa049180.55222028
101GnRH signaling pathway_Homo sapiens_hsa049120.55042589
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53102839
103MAPK signaling pathway_Homo sapiens_hsa040100.52845378
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52144240
105Chronic myeloid leukemia_Homo sapiens_hsa052200.51632385
106beta-Alanine metabolism_Homo sapiens_hsa004100.51445698
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51385009
108Fatty acid degradation_Homo sapiens_hsa000710.51247469
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.49328440
110Linoleic acid metabolism_Homo sapiens_hsa005910.49271434
111Pyruvate metabolism_Homo sapiens_hsa006200.48828064
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.48259587
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48210713
114Lysosome_Homo sapiens_hsa041420.48068824
115ABC transporters_Homo sapiens_hsa020100.48020258
116Fatty acid elongation_Homo sapiens_hsa000620.47809068
117Cell cycle_Homo sapiens_hsa041100.47227249
118Viral myocarditis_Homo sapiens_hsa054160.47043926
119Acute myeloid leukemia_Homo sapiens_hsa052210.46763913
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42301093
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41962406
122Estrogen signaling pathway_Homo sapiens_hsa049150.41141005
123Rap1 signaling pathway_Homo sapiens_hsa040150.39582434
124Melanoma_Homo sapiens_hsa052180.35116858
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34928338
126Galactose metabolism_Homo sapiens_hsa000520.34008474
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.33883253
128Melanogenesis_Homo sapiens_hsa049160.33511838
129Arachidonic acid metabolism_Homo sapiens_hsa005900.32989962
130Pathways in cancer_Homo sapiens_hsa052000.31536569
131Fat digestion and absorption_Homo sapiens_hsa049750.29785277
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.29473899
133Olfactory transduction_Homo sapiens_hsa047400.29302803
134Starch and sucrose metabolism_Homo sapiens_hsa005000.28590241
135Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28009186
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26310990
137Endocytosis_Homo sapiens_hsa041440.25907467
138Legionellosis_Homo sapiens_hsa051340.23057320
139Primary immunodeficiency_Homo sapiens_hsa053400.23051368
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22635961
141Prostate cancer_Homo sapiens_hsa052150.21147392
142Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21028513
143Ras signaling pathway_Homo sapiens_hsa040140.20809889
144Viral carcinogenesis_Homo sapiens_hsa052030.20399254

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