ARHGAP42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.76584668
2L-phenylalanine catabolic process (GO:0006559)6.76584668
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.53336281
4L-phenylalanine metabolic process (GO:0006558)6.53336281
5aromatic amino acid family catabolic process (GO:0009074)6.33578162
6tryptophan catabolic process (GO:0006569)5.98813931
7indole-containing compound catabolic process (GO:0042436)5.98813931
8indolalkylamine catabolic process (GO:0046218)5.98813931
9kynurenine metabolic process (GO:0070189)5.68644274
10tryptophan metabolic process (GO:0006568)5.67645463
11glyoxylate metabolic process (GO:0046487)5.59190458
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.52520358
13bile acid biosynthetic process (GO:0006699)5.52193278
14cysteine metabolic process (GO:0006534)5.45417609
15urea metabolic process (GO:0019627)5.24567444
16urea cycle (GO:0000050)5.24567444
17homocysteine metabolic process (GO:0050667)5.23970129
18sulfur amino acid catabolic process (GO:0000098)5.19786247
19regulation of cardioblast differentiation (GO:0051890)5.15959800
20regulation of protein activation cascade (GO:2000257)5.13174955
21negative regulation of fibrinolysis (GO:0051918)5.12174600
22alpha-linolenic acid metabolic process (GO:0036109)5.09206339
23serine family amino acid catabolic process (GO:0009071)5.08446284
24regulation of transforming growth factor beta2 production (GO:0032909)5.05665274
25regulation of fibrinolysis (GO:0051917)4.94751435
26regulation of complement activation (GO:0030449)4.85931819
27peptidyl-glutamic acid carboxylation (GO:0017187)4.85750065
28protein carboxylation (GO:0018214)4.85750065
29complement activation, alternative pathway (GO:0006957)4.85661664
30lysine metabolic process (GO:0006553)4.80072158
31lysine catabolic process (GO:0006554)4.80072158
32bile acid metabolic process (GO:0008206)4.79617221
33high-density lipoprotein particle remodeling (GO:0034375)4.79566284
34nitrogen cycle metabolic process (GO:0071941)4.76260433
35aromatic amino acid family metabolic process (GO:0009072)4.61275169
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.57354624
37amino-acid betaine metabolic process (GO:0006577)4.46546115
38bile acid and bile salt transport (GO:0015721)4.36702761
39alpha-amino acid catabolic process (GO:1901606)4.35845128
40cellular glucuronidation (GO:0052695)4.33843663
41reverse cholesterol transport (GO:0043691)4.32130487
42tyrosine metabolic process (GO:0006570)4.31034952
43negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.30300953
44regulation of triglyceride catabolic process (GO:0010896)4.25552467
45acylglycerol homeostasis (GO:0055090)4.23313168
46triglyceride homeostasis (GO:0070328)4.23313168
47paraxial mesoderm development (GO:0048339)4.23284291
48protein-lipid complex remodeling (GO:0034368)4.19968913
49macromolecular complex remodeling (GO:0034367)4.19968913
50plasma lipoprotein particle remodeling (GO:0034369)4.19968913
51glycine metabolic process (GO:0006544)4.17703145
52indolalkylamine metabolic process (GO:0006586)4.16688850
53bundle of His cell to Purkinje myocyte communication (GO:0086069)4.16249292
54serine family amino acid metabolic process (GO:0009069)4.15450556
55amine catabolic process (GO:0009310)4.14933377
56cellular biogenic amine catabolic process (GO:0042402)4.14933377
57regulation of bile acid biosynthetic process (GO:0070857)4.14273779
58negative regulation of hormone biosynthetic process (GO:0032353)4.12735540
59drug catabolic process (GO:0042737)4.12244300
60cellular ketone body metabolic process (GO:0046950)4.11691866
61regulation of relaxation of muscle (GO:1901077)4.09687986
62negative regulation of sterol transport (GO:0032372)4.07037823
63negative regulation of cholesterol transport (GO:0032375)4.07037823
64cellular amino acid catabolic process (GO:0009063)4.04002982
65cellular modified amino acid catabolic process (GO:0042219)4.03889611
66regulation of cholesterol esterification (GO:0010872)3.99409873
67glutamate metabolic process (GO:0006536)3.97929097
68benzene-containing compound metabolic process (GO:0042537)3.97828656
69cardiac myofibril assembly (GO:0055003)3.95755526
70serine family amino acid biosynthetic process (GO:0009070)3.95748209
71urate metabolic process (GO:0046415)3.94347675
72epoxygenase P450 pathway (GO:0019373)3.93475292
73coenzyme catabolic process (GO:0009109)3.91855062
74uronic acid metabolic process (GO:0006063)3.90655511
75glucuronate metabolic process (GO:0019585)3.90655511
76ethanol oxidation (GO:0006069)3.90197185
77regulation of cholesterol homeostasis (GO:2000188)3.88382722
78phospholipid efflux (GO:0033700)3.85700352
79dicarboxylic acid biosynthetic process (GO:0043650)3.85063241
80imidazole-containing compound metabolic process (GO:0052803)3.84418284
81fibrinolysis (GO:0042730)3.80227328
82arginine metabolic process (GO:0006525)3.74079769
83negative regulation of hormone metabolic process (GO:0032351)3.73520241
84embryonic foregut morphogenesis (GO:0048617)3.72170252
85positive regulation of fatty acid beta-oxidation (GO:0032000)3.71778461
86response to nitrosative stress (GO:0051409)3.71724626
87notochord development (GO:0030903)3.66990914
88positive regulation of cardiac muscle cell proliferation (GO:0060045)3.66642332
89positive regulation of catenin import into nucleus (GO:0035413)3.66334463
90plasma lipoprotein particle clearance (GO:0034381)3.65909194
91retina vasculature morphogenesis in camera-type eye (GO:0061299)3.59019980
92cholesterol efflux (GO:0033344)3.56325138
93drug transmembrane transport (GO:0006855)3.55367180
94low-density lipoprotein particle remodeling (GO:0034374)3.54769170
95ketone body metabolic process (GO:1902224)3.53290758
96regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.52077072
97exogenous drug catabolic process (GO:0042738)3.51105975
98acetyl-CoA metabolic process (GO:0006084)3.50650719
99positive regulation of lipid catabolic process (GO:0050996)3.49311938
100positive regulation of SMAD protein import into nucleus (GO:0060391)3.48700637
101plasma lipoprotein particle assembly (GO:0034377)3.48504773
102organic acid catabolic process (GO:0016054)3.46863500
103carboxylic acid catabolic process (GO:0046395)3.46863500
104phospholipid homeostasis (GO:0055091)3.46169288
105very-low-density lipoprotein particle assembly (GO:0034379)3.44281147
106regulation of glucocorticoid metabolic process (GO:0031943)3.43543488
107myofibril assembly (GO:0030239)3.43417528
108cholesterol homeostasis (GO:0042632)3.42744350
109negative regulation of protein activation cascade (GO:2000258)3.40880324
110sterol homeostasis (GO:0055092)3.39979590
111aldehyde catabolic process (GO:0046185)3.38970750
112short-chain fatty acid metabolic process (GO:0046459)3.38878254
113sequestering of extracellular ligand from receptor (GO:0035581)3.37587594
114negative regulation of lipase activity (GO:0060192)3.37538021
115aspartate family amino acid catabolic process (GO:0009068)3.36305215
116lipoprotein metabolic process (GO:0042157)3.35760932
117gap junction assembly (GO:0016264)3.34374977
118complement activation, classical pathway (GO:0006958)3.34266684
119positive regulation of cardiac muscle tissue development (GO:0055025)3.32763108
120anterior/posterior axis specification, embryo (GO:0008595)3.32756583
121ventricular cardiac muscle cell development (GO:0055015)3.32175346
122midgut development (GO:0007494)3.31413183
123positive regulation of cardiac muscle tissue growth (GO:0055023)3.30434689
124complement activation (GO:0006956)3.29859616
125nuclear pore complex assembly (GO:0051292)3.29803405
126endocardial cushion morphogenesis (GO:0003203)3.27491780
127pericardium development (GO:0060039)3.21625865
128cardiac muscle hypertrophy (GO:0003300)3.18691148
129mesenchyme morphogenesis (GO:0072132)3.18428589
130striated muscle hypertrophy (GO:0014897)3.14177769
131gastrulation with mouth forming second (GO:0001702)3.12449549
132regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.10426056
133pre-miRNA processing (GO:0031054)3.09059144
134negative regulation of striated muscle cell apoptotic process (GO:0010664)3.03417301
135cellular response to BMP stimulus (GO:0071773)2.99490252
136response to BMP (GO:0071772)2.99490252
137cardiac right ventricle morphogenesis (GO:0003215)2.99206057
138establishment of apical/basal cell polarity (GO:0035089)2.98518512
139regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.98386334
140male genitalia development (GO:0030539)2.96594125
141hippo signaling (GO:0035329)2.96282631
142cardiac muscle cell development (GO:0055013)2.96112486
143nuclear pore organization (GO:0006999)2.93399721
144dorsal/ventral axis specification (GO:0009950)2.93208244
145desmosome organization (GO:0002934)2.92532535
146positive regulation of heart growth (GO:0060421)2.92493527
147regulation of cardiac muscle tissue development (GO:0055024)2.87389393
148regulation of posttranscriptional gene silencing (GO:0060147)2.86985074
149regulation of gene silencing by miRNA (GO:0060964)2.86985074
150regulation of gene silencing by RNA (GO:0060966)2.86985074
151cardiac cell development (GO:0055006)2.85764882
152mesenchymal cell differentiation (GO:0048762)2.85629345
153relaxation of cardiac muscle (GO:0055119)2.84527021
154regulation of cardiac muscle cell proliferation (GO:0060043)2.83953447
155atrioventricular valve morphogenesis (GO:0003181)2.82602246
156regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.79806163
157genitalia morphogenesis (GO:0035112)2.75930430
158morphogenesis of an epithelial sheet (GO:0002011)2.74274194
159regulation of steroid hormone biosynthetic process (GO:0090030)2.71604692
160cardiac epithelial to mesenchymal transition (GO:0060317)2.69277290
161regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.68911979
162atrial septum morphogenesis (GO:0060413)2.67399325
163cell migration involved in gastrulation (GO:0042074)2.64650781
164regulation of SMAD protein import into nucleus (GO:0060390)2.62751635
165positive regulation of cardiac muscle cell differentiation (GO:2000727)2.61298997
166regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.61087585
167regulation of cardiac muscle cell differentiation (GO:2000725)2.60478305
168sarcomere organization (GO:0045214)2.60395598
169negative regulation of keratinocyte proliferation (GO:0010839)2.58340410
170adult heart development (GO:0007512)2.58234975
171outflow tract septum morphogenesis (GO:0003148)2.57952132
172glomerulus development (GO:0032835)2.55852016
173regulation of coenzyme metabolic process (GO:0051196)2.55461925
174regulation of cofactor metabolic process (GO:0051193)2.55461925
175regulation of acyl-CoA biosynthetic process (GO:0050812)2.55384240
176cardiac muscle tissue morphogenesis (GO:0055008)2.53975215
177regulation of cardiac muscle cell apoptotic process (GO:0010665)2.53522310
178muscle hypertrophy (GO:0014896)2.53413382
179negative regulation of chondrocyte differentiation (GO:0032331)2.52188123
180regulation of cell communication by electrical coupling (GO:0010649)2.52039518
181mitotic sister chromatid cohesion (GO:0007064)2.50098651
182anterior/posterior axis specification (GO:0009948)2.47123016
183SMAD protein signal transduction (GO:0060395)2.47012515
184otic vesicle formation (GO:0030916)2.47010576
185embryonic heart tube development (GO:0035050)2.46976396
186regulation of sulfur metabolic process (GO:0042762)2.46378125
187regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.46119445
188positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.45281688
189lymphangiogenesis (GO:0001946)2.44462304
190reproductive system development (GO:0061458)2.44232359
191cell surface receptor signaling pathway involved in heart development (GO:0061311)2.43744044
192nodal signaling pathway (GO:0038092)2.43155546
193establishment or maintenance of monopolar cell polarity (GO:0061339)2.41254333
194establishment of monopolar cell polarity (GO:0061162)2.41254333
195mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.40976955
196positive regulation of muscle tissue development (GO:1901863)2.40653210
197heart valve morphogenesis (GO:0003179)2.39900858
198heart valve formation (GO:0003188)2.39546440
199muscle hypertrophy in response to stress (GO:0003299)2.39391196
200cardiac muscle adaptation (GO:0014887)2.39391196

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.23685972
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.15781934
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.90809414
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.74511325
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.25512718
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.82749749
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.82105201
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.72817397
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.87943007
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.51734242
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.41611312
12E2F7_22180533_ChIP-Seq_HELA_Human2.40653349
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.39005668
14CLOCK_20551151_ChIP-Seq_293T_Human2.28756272
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16727339
16FUS_26573619_Chip-Seq_HEK293_Human2.14831520
17GBX2_23144817_ChIP-Seq_PC3_Human2.01614709
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1062843
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.93442458
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.93442458
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.93442458
22TP63_17297297_ChIP-ChIP_HaCaT_Human1.90105675
23P300_19829295_ChIP-Seq_ESCs_Human1.86450402
24HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.85203979
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83758890
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.81930973
27SMAD3_21741376_ChIP-Seq_EPCs_Human1.79455238
28SMAD3_21741376_ChIP-Seq_HESCs_Human1.79387805
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78081317
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.74381567
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.73384349
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69887536
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.68314561
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66323628
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.64901633
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.63901843
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.63821425
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63617389
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63040495
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60470996
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55674808
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54166605
43SMAD4_21799915_ChIP-Seq_A2780_Human1.53771194
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53413532
45EWS_26573619_Chip-Seq_HEK293_Human1.51381906
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49623756
47VDR_22108803_ChIP-Seq_LS180_Human1.47855730
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46686120
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45975358
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41734299
51HNF4A_19822575_ChIP-Seq_HepG2_Human1.40146061
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39145516
53TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.38235434
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.37898270
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.36075273
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.35973587
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34527335
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33146316
59STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.30918508
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29447298
61TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27939839
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.26199829
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25313249
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25049528
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23892376
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23892376
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.21716843
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21703025
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21558743
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20690694
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19759644
72STAT3_23295773_ChIP-Seq_U87_Human1.19328911
73ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.19236090
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18985369
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18863546
76TCF3_18692474_ChIP-Seq_MESCs_Mouse1.18603270
77TBX3_20139965_ChIP-Seq_MESCs_Mouse1.18543428
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18263067
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16492225
80HTT_18923047_ChIP-ChIP_STHdh_Human1.13953423
81CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13780877
82NANOG_16153702_ChIP-ChIP_HESCs_Human1.13672499
83LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13503232
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13486368
85SOX9_26525672_Chip-Seq_HEART_Mouse1.13395543
86GATA4_25053715_ChIP-Seq_YYC3_Human1.13272926
87FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.10300567
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09906588
89PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09725725
90SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09050740
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07094861
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.06978408
93AR_21909140_ChIP-Seq_LNCAP_Human1.05900762
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.05804284
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04990029
96RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04537254
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03764177
98TCF4_23295773_ChIP-Seq_U87_Human1.02890182
99SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02649574
100GF1B_26923725_Chip-Seq_HPCs_Mouse1.01631021
101TCF4_22108803_ChIP-Seq_LS180_Human1.01169173
102RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00429971
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.00407774
104KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00328012
105GATA1_26923725_Chip-Seq_HPCs_Mouse0.99779494
106CDX2_20551321_ChIP-Seq_CACO-2_Human0.99712206
107BCAT_22108803_ChIP-Seq_LS180_Human0.99298651
108SMAD_19615063_ChIP-ChIP_OVARY_Human0.99239421
109FOXO3_23340844_ChIP-Seq_DLD1_Human0.99203584
110CJUN_26792858_Chip-Seq_BT549_Human0.96878231
111CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96778338
112AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96474881
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96264972
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95820544
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91198823
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88096167
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85485217
118NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.82605412
119SOX2_20726797_ChIP-Seq_SW620_Human0.82197420
120RXRA_24833708_ChIP-Seq_LIVER_Mouse0.81741513
121FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81674282
122SALL1_21062744_ChIP-ChIP_HESCs_Human0.80628955
123KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80074438
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79038644
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.75809422
126CDX2_22108803_ChIP-Seq_LS180_Human0.75592587
127ZNF263_19887448_ChIP-Seq_K562_Human0.74823754
128TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74151275
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.72468086
130* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.72113905
131PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.68902714
132EP300_21415370_ChIP-Seq_HL-1_Mouse0.68728625
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68000072
134RXR_22108803_ChIP-Seq_LS180_Human0.67863700
135CDX2_19796622_ChIP-Seq_MESCs_Mouse0.66650322
136GATA6_25053715_ChIP-Seq_YYC3_Human0.66385745
137TCF3_18692474_ChIP-Seq_MEFs_Mouse0.65846546
138FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.65423165
139POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.65390699
140FOXA1_25552417_ChIP-Seq_VCAP_Human0.64697884
141TAF15_26573619_Chip-Seq_HEK293_Human0.64481574
142TP63_23658742_ChIP-Seq_EP156T_Human0.63081577
143TP53_18474530_ChIP-ChIP_U2OS_Human0.61845824
144TP53_16413492_ChIP-PET_HCT116_Human0.61651331
145FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.61277429
146GATA3_24758297_ChIP-Seq_MCF-7_Human0.60545942
147ISL1_27105846_Chip-Seq_CPCs_Mouse0.60397412
148NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.60086408
149AHR_22903824_ChIP-Seq_MCF-7_Human0.59430640
150THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.59061574
151RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.58639056
152BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.58392882
153NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57155004
154GATA1_22025678_ChIP-Seq_K562_Human0.57149932
155TCF4_18268006_ChIP-ChIP_LS174T_Human0.56769934
156CBP_21632823_ChIP-Seq_H3396_Human0.56611864
157BRD4_25478319_ChIP-Seq_HGPS_Human0.55505367
158Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.54691049
159SMAD4_21741376_ChIP-Seq_HESCs_Human0.54035020
160PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.53400274
161ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.52569680
162NANOG_16518401_ChIP-PET_MESCs_Mouse0.52510868
163TBX3_20139965_ChIP-Seq_ESCs_Mouse0.52158242
164ARNT_22903824_ChIP-Seq_MCF-7_Human0.50746580

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.65695551
2MP0005360_urolithiasis7.47380094
3MP0005085_abnormal_gallbladder_physiolo5.91657086
4MP0005365_abnormal_bile_salt5.61250122
5MP0008875_abnormal_xenobiotic_pharmacok4.58449784
6MP0003252_abnormal_bile_duct4.03369419
7MP0003806_abnormal_nucleotide_metabolis3.49105288
8MP0003890_abnormal_embryonic-extraembry3.38255965
9MP0010329_abnormal_lipoprotein_level3.16079511
10MP0002102_abnormal_ear_morphology2.86399148
11MP0005332_abnormal_amino_acid2.64460718
12MP0003195_calcinosis2.50123411
13MP0003705_abnormal_hypodermis_morpholog2.45702249
14MP0009840_abnormal_foam_cell2.43524285
15MP0004019_abnormal_vitamin_homeostasis2.38377341
16MP0001666_abnormal_nutrient_absorption2.35189766
17MP0008057_abnormal_DNA_replication2.30044931
18MP0005083_abnormal_biliary_tract2.22769368
19MP0003136_yellow_coat_color2.21973243
20MP0003937_abnormal_limbs/digits/tail_de2.19299616
21MP0002138_abnormal_hepatobiliary_system1.95850589
22MP0003385_abnormal_body_wall1.93860313
23MP0000462_abnormal_digestive_system1.92719983
24MP0004215_abnormal_myocardial_fiber1.88814222
25MP0003119_abnormal_digestive_system1.86333566
26MP0004084_abnormal_cardiac_muscle1.85999432
27MP0003868_abnormal_feces_composition1.84114964
28MP0002697_abnormal_eye_size1.78795328
29MP0000609_abnormal_liver_physiology1.77411015
30MP0002233_abnormal_nose_morphology1.75505129
31MP0002118_abnormal_lipid_homeostasis1.71201825
32MP0003567_abnormal_fetal_cardiomyocyte1.70037588
33MP0002254_reproductive_system_inflammat1.68019057
34MP0003950_abnormal_plasma_membrane1.66822902
35MP0009384_cardiac_valve_regurgitation1.65280997
36MP0009697_abnormal_copulation1.63253173
37MP0009053_abnormal_anal_canal1.56938961
38MP0010352_gastrointestinal_tract_polyps1.56188328
39MP0002084_abnormal_developmental_patter1.52546157
40MP0009250_abnormal_appendicular_skeleto1.52495725
41MP0006054_spinal_hemorrhage1.50949583
42MP0005319_abnormal_enzyme/_coenzyme1.46572246
43MP0004036_abnormal_muscle_relaxation1.45756715
44MP0000534_abnormal_ureter_morphology1.44524414
45MP0005330_cardiomyopathy1.44365623
46MP0003191_abnormal_cellular_cholesterol1.44288429
47MP0003984_embryonic_growth_retardation1.40596455
48MP0002088_abnormal_embryonic_growth/wei1.38262952
49MP0004957_abnormal_blastocyst_morpholog1.38029283
50MP0001672_abnormal_embryogenesis/_devel1.36268113
51MP0005380_embryogenesis_phenotype1.36268113
52MP0003935_abnormal_craniofacial_develop1.35917254
53MP0001299_abnormal_eye_distance/1.34350201
54MP0000372_irregular_coat_pigmentation1.33465905
55MP0001293_anophthalmia1.31254924
56MP0010368_abnormal_lymphatic_system1.31103574
57MP0008438_abnormal_cutaneous_collagen1.29169501
58MP0005451_abnormal_body_composition1.24183819
59MP0004145_abnormal_muscle_electrophysio1.22330049
60MP0000428_abnormal_craniofacial_morphol1.21328066
61MP0008775_abnormal_heart_ventricle1.19004449
62MP0001286_abnormal_eye_development1.18856840
63MP0009643_abnormal_urine_homeostasis1.18345416
64MP0005257_abnormal_intraocular_pressure1.17481265
65MP0002972_abnormal_cardiac_muscle1.17066673
66MP0005647_abnormal_sex_gland1.16079244
67MP0000749_muscle_degeneration1.14693096
68MP0002127_abnormal_cardiovascular_syste1.14542958
69MP0002085_abnormal_embryonic_tissue1.14530803
70MP0000751_myopathy1.13746482
71MP0010630_abnormal_cardiac_muscle1.13733485
72MP0005197_abnormal_uvea_morphology1.12392165
73MP0008932_abnormal_embryonic_tissue1.09548371
74MP0005584_abnormal_enzyme/coenzyme_acti1.09246995
75MP0005171_absent_coat_pigmentation1.08516972
76MP0006138_congestive_heart_failure1.07069320
77MP0000516_abnormal_urinary_system1.07032712
78MP0005367_renal/urinary_system_phenotyp1.07032712
79MP0002938_white_spotting1.06482671
80MP0002086_abnormal_extraembryonic_tissu1.05922667
81MP0005409_darkened_coat_color1.05194546
82MP0005248_abnormal_Harderian_gland1.04765800
83MP0003755_abnormal_palate_morphology1.04658002
84MP0002111_abnormal_tail_morphology1.03364763
85MP0005275_abnormal_skin_tensile1.01873331
86MP0003011_delayed_dark_adaptation1.01654694
87MP0000432_abnormal_head_morphology1.01149863
88MP0002925_abnormal_cardiovascular_devel1.00725599
89MP0001764_abnormal_homeostasis1.00616295
90MP0004197_abnormal_fetal_growth/weight/0.99395699
91MP0003566_abnormal_cell_adhesion0.97381788
92MP0005084_abnormal_gallbladder_morpholo0.97252124
93MP0000767_abnormal_smooth_muscle0.97102544
94MP0009703_decreased_birth_body0.97060764
95MP0001879_abnormal_lymphatic_vessel0.96780291
96MP0001730_embryonic_growth_arrest0.96582760
97MP0000598_abnormal_liver_morphology0.96514484
98MP0005620_abnormal_muscle_contractility0.95989401
99MP0003283_abnormal_digestive_organ0.95023290
100MP0004085_abnormal_heartbeat0.93658241
101MP0005623_abnormal_meninges_morphology0.92182435
102MP0005408_hypopigmentation0.92058753
103MP0001697_abnormal_embryo_size0.92025028
104MP0003186_abnormal_redox_activity0.90368915
105MP0002009_preneoplasia0.89994157
106MP0005670_abnormal_white_adipose0.89057464
107MP0001915_intracranial_hemorrhage0.87349589
108MP0002109_abnormal_limb_morphology0.87111565
109MP0000266_abnormal_heart_morphology0.86660372
110MP0004087_abnormal_muscle_fiber0.86170652
111MP0002060_abnormal_skin_morphology0.84684510
112MP0000579_abnormal_nail_morphology0.83786662
113MP0002128_abnormal_blood_circulation0.83486950
114MP0002249_abnormal_larynx_morphology0.83121708
115MP0004272_abnormal_basement_membrane0.81646976
116MP0004133_heterotaxia0.80602218
117MP0005395_other_phenotype0.79628798
118MP0001177_atelectasis0.78165242
119MP0009764_decreased_sensitivity_to0.77819799
120MP0004510_myositis0.77264293
121MP0010234_abnormal_vibrissa_follicle0.76232639
122MP0005503_abnormal_tendon_morphology0.75894206
123MP0005220_abnormal_exocrine_pancreas0.74974699
124MP0010030_abnormal_orbit_morphology0.74292868
125MP0005636_abnormal_mineral_homeostasis0.74226512
126MP0001756_abnormal_urination0.72131516
127MP0002282_abnormal_trachea_morphology0.72129835
128MP0003718_maternal_effect0.71506465
129MP0002168_other_aberrant_phenotype0.69284771
130MP0001661_extended_life_span0.68344685
131MP0004264_abnormal_extraembryonic_tissu0.66547886
132MP0002796_impaired_skin_barrier0.65226386
133MP0005666_abnormal_adipose_tissue0.64547516
134MP0000566_synostosis0.62585238
135MP0002971_abnormal_brown_adipose0.61642603
136MP0005023_abnormal_wound_healing0.61581142
137MP0005187_abnormal_penis_morphology0.61529054
138MP0009763_increased_sensitivity_to0.61436270
139MP0000427_abnormal_hair_cycle0.59022912
140MP0009642_abnormal_blood_homeostasis0.57717063
141MP0002928_abnormal_bile_duct0.56643781
142MP0002876_abnormal_thyroid_physiology0.55202406
143MP0005376_homeostasis/metabolism_phenot0.55121044
144MP0003115_abnormal_respiratory_system0.54654457
145MP0003656_abnormal_erythrocyte_physiolo0.53691351
146MP0009672_abnormal_birth_weight0.53411250
147MP0005334_abnormal_fat_pad0.53193589
148MP0000639_abnormal_adrenal_gland0.52874166
149MP0003453_abnormal_keratinocyte_physiol0.50984255
150MP0000538_abnormal_urinary_bladder0.49682994
151MP0003279_aneurysm0.49615185
152MP0001243_abnormal_dermal_layer0.48884253
153MP0002136_abnormal_kidney_physiology0.48529365
154MP0000537_abnormal_urethra_morphology0.48311532
155MP0000647_abnormal_sebaceous_gland0.47949885
156MP0001881_abnormal_mammary_gland0.47690019
157MP0002098_abnormal_vibrissa_morphology0.47648777
158MP0000377_abnormal_hair_follicle0.45682656
159MP0003941_abnormal_skin_development0.45034190
160MP0004130_abnormal_muscle_cell0.44975098
161MP0002896_abnormal_bone_mineralization0.44784971
162MP0010678_abnormal_skin_adnexa0.43246055
163MP0002295_abnormal_pulmonary_circulatio0.42882285
164MP0000762_abnormal_tongue_morphology0.42609838
165MP0002078_abnormal_glucose_homeostasis0.42399864
166MP0000163_abnormal_cartilage_morphology0.42305433
167MP0009765_abnormal_xenobiotic_induced0.41930275
168MP0003942_abnormal_urinary_system0.41664603
169MP0009115_abnormal_fat_cell0.40780780
170MP0002108_abnormal_muscle_morphology0.40522022
171MP0000467_abnormal_esophagus_morphology0.40196661
172MP0005508_abnormal_skeleton_morphology0.39783192
173MP0005266_abnormal_metabolism0.39560191
174MP0002092_abnormal_eye_morphology0.39105374

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.11580267
2Deep venous thrombosis (HP:0002625)6.94862684
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.28769551
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.23452313
5Xanthomatosis (HP:0000991)6.09218426
6Hypobetalipoproteinemia (HP:0003563)5.82875449
7Prolonged partial thromboplastin time (HP:0003645)5.45513810
8Complement deficiency (HP:0004431)4.94360355
9Hypolipoproteinemia (HP:0010981)4.63342651
10Abnormality of glutamine family amino acid metabolism (HP:0010902)4.62148533
11Hyperglycinemia (HP:0002154)4.60116896
12Epidermoid cyst (HP:0200040)4.58089110
13Hyperlipoproteinemia (HP:0010980)4.57848255
14Hyperglycinuria (HP:0003108)4.36927938
15Hyperammonemia (HP:0001987)4.30784567
16Hypoalphalipoproteinemia (HP:0003233)4.25506383
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.20665618
18Right ventricular cardiomyopathy (HP:0011663)4.20624778
19Abnormality of serine family amino acid metabolism (HP:0010894)4.15505339
20Abnormality of glycine metabolism (HP:0010895)4.15505339
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.06506420
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.04615833
23Fat malabsorption (HP:0002630)3.91455549
24Abnormality of the common coagulation pathway (HP:0010990)3.85396648
25Ketosis (HP:0001946)3.80495154
26Abnormality of methionine metabolism (HP:0010901)3.75864942
27Joint hemorrhage (HP:0005261)3.67206405
28Conjugated hyperbilirubinemia (HP:0002908)3.60822898
29Abnormality of complement system (HP:0005339)3.56622479
30Abnormality of pyrimidine metabolism (HP:0004353)3.37155681
31Hypoglycemic coma (HP:0001325)3.31206904
32Abnormality of the intrinsic pathway (HP:0010989)3.29945607
33Myelomeningocele (HP:0002475)3.28137230
34Preaxial foot polydactyly (HP:0001841)3.24837758
35Abnormality of serum amino acid levels (HP:0003112)3.19654573
36Abnormality of the ischium (HP:0003174)3.14702509
37Myocardial infarction (HP:0001658)3.12992576
38Hepatocellular carcinoma (HP:0001402)3.12096473
39Hypercholesterolemia (HP:0003124)3.10361231
40Abnormality of nucleobase metabolism (HP:0010932)3.07493316
41Gout (HP:0001997)2.99132957
42Abnormality of fatty-acid metabolism (HP:0004359)2.94175805
43Abnormality of purine metabolism (HP:0004352)2.92662134
44Delayed CNS myelination (HP:0002188)2.86225442
45Vascular calcification (HP:0004934)2.86068988
46Abnormal pancreas size (HP:0012094)2.83791591
47Cardiovascular calcification (HP:0011915)2.82986138
48Skin nodule (HP:0200036)2.80006490
49Ketoacidosis (HP:0001993)2.78099091
50Spontaneous abortion (HP:0005268)2.74572026
51Ventricular tachycardia (HP:0004756)2.71357525
52Steatorrhea (HP:0002570)2.70590488
53Bifid tongue (HP:0010297)2.66595941
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.63264018
55Abnormality of the calf musculature (HP:0001430)2.62457917
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.61249819
57Spastic diplegia (HP:0001264)2.61052819
58Hyperbilirubinemia (HP:0002904)2.60872881
59Short tibia (HP:0005736)2.59970971
60Mitral stenosis (HP:0001718)2.50412245
61Arterial tortuosity (HP:0005116)2.48641346
62Malnutrition (HP:0004395)2.48492868
63Metabolic acidosis (HP:0001942)2.48092657
64Hypochromic microcytic anemia (HP:0004840)2.47170823
65Double outlet right ventricle (HP:0001719)2.43503497
66Congenital malformation of the right heart (HP:0011723)2.43503497
67Abnormality of proline metabolism (HP:0010907)2.37910374
68Hydroxyprolinuria (HP:0003080)2.37910374
69Esophageal varix (HP:0002040)2.33403857
70Bell-shaped thorax (HP:0001591)2.33260140
71Enlarged kidneys (HP:0000105)2.32811264
72Rickets (HP:0002748)2.30835477
73Vertebral clefting (HP:0008428)2.30738079
74Aplasia involving bones of the extremities (HP:0009825)2.30029680
75Aplasia involving bones of the upper limbs (HP:0009823)2.30029680
76Aplasia of the phalanges of the hand (HP:0009802)2.30029680
77Short hallux (HP:0010109)2.29654021
78Lethargy (HP:0001254)2.28811451
79Patent foramen ovale (HP:0001655)2.28700842
80Dicarboxylic aciduria (HP:0003215)2.25322282
81Abnormality of dicarboxylic acid metabolism (HP:0010995)2.25322282
82Vertebral arch anomaly (HP:0008438)2.20825652
83Anal stenosis (HP:0002025)2.20490286
84Protrusio acetabuli (HP:0003179)2.20445767
85Absent eyebrow (HP:0002223)2.20305053
86Vitreoretinal degeneration (HP:0000655)2.19920191
87Limited hip movement (HP:0008800)2.17683696
88Cutaneous finger syndactyly (HP:0010554)2.16968584
89Vascular tortuosity (HP:0004948)2.15712534
90Abnormal cartilage morphology (HP:0002763)2.15293831
91Neoplasm of the small intestine (HP:0100833)2.13966845
92Periauricular skin pits (HP:0100277)2.12939138
93Preauricular pit (HP:0004467)2.12939138
94Sensorimotor neuropathy (HP:0007141)2.12242156
95Proximal tubulopathy (HP:0000114)2.11774217
96Abnormality of the phalanges of the 2nd finger (HP:0009541)2.11736840
97Acanthocytosis (HP:0001927)2.11507267
98Hyperuricemia (HP:0002149)2.10749592
99Increased purine levels (HP:0004368)2.10749592
100Neonatal onset (HP:0003623)2.10520835
101Osteomalacia (HP:0002749)2.09653676
102Aplasia/Hypoplasia of the hallux (HP:0008362)2.08009782
103Papillary thyroid carcinoma (HP:0002895)2.07981568
104Hypophosphatemic rickets (HP:0004912)2.06357961
105Back pain (HP:0003418)2.06253506
106Partial duplication of thumb phalanx (HP:0009944)2.05322904
107Knee flexion contracture (HP:0006380)2.05153095
108Embryonal renal neoplasm (HP:0011794)2.04696995
109Ankyloglossia (HP:0010296)2.03832527
110Intestinal atresia (HP:0011100)2.02786539
111Hyperglycemia (HP:0003074)2.02664557
112Hepatoblastoma (HP:0002884)2.02016651
113Abnormal auditory evoked potentials (HP:0006958)2.00706073
114Alopecia of scalp (HP:0002293)1.99787080
115Partial duplication of the phalanx of hand (HP:0009999)1.97566758
116Cutaneous syndactyly (HP:0012725)1.97387964
117Absent radius (HP:0003974)1.97246428
118Transposition of the great arteries (HP:0001669)1.96321296
119Abnormal connection of the cardiac segments (HP:0011545)1.96321296
120Abnormal ventriculo-arterial connection (HP:0011563)1.96321296
121Abnormal lung lobation (HP:0002101)1.95489977
122Irritability (HP:0000737)1.94216524
123Colon cancer (HP:0003003)1.92959770
124Sudden death (HP:0001699)1.91692509
125Duplication of thumb phalanx (HP:0009942)1.90720651
126Skin pits (HP:0100276)1.88521117
127Systemic lupus erythematosus (HP:0002725)1.87481626
128Abnormality of the middle phalanges of the toes (HP:0010183)1.86541709
129Cupped ear (HP:0000378)1.85647685
130Facial cleft (HP:0002006)1.85464309
131Abnormal gallbladder morphology (HP:0012437)1.84923918
132Hypoglycemic seizures (HP:0002173)1.84841062
133Cholelithiasis (HP:0001081)1.81929869
134Opisthotonus (HP:0002179)1.80514516
135Abnormality of the dental root (HP:0006486)1.80244912
136Taurodontia (HP:0000679)1.80244912
137Abnormality of permanent molar morphology (HP:0011071)1.80244912
138Abnormality of the dental pulp (HP:0006479)1.80041167
139Gastrointestinal carcinoma (HP:0002672)1.79872929
140Malignant gastrointestinal tract tumors (HP:0006749)1.79872929
141Premature rupture of membranes (HP:0001788)1.79607698
142Aplasia involving forearm bones (HP:0009822)1.79505238
143Absent forearm bone (HP:0003953)1.79505238
144Renal hypoplasia (HP:0000089)1.79298101
145Calf muscle hypertrophy (HP:0008981)1.78221873
146Omphalocele (HP:0001539)1.77370133
147Exercise-induced muscle cramps (HP:0003710)1.76585703
148Alkalosis (HP:0001948)1.76528981
149Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.75410607
150Abnormality of the fetal cardiovascular system (HP:0010948)1.74547907
151Abnormal umbilical cord blood vessels (HP:0011403)1.74547907
152Single umbilical artery (HP:0001195)1.74547907
153Abnormal vertebral ossification (HP:0100569)1.74537569
154Anophthalmia (HP:0000528)1.74369765
155Hip contracture (HP:0003273)1.74124723
156Chorioretinal atrophy (HP:0000533)1.73757744
157Abnormal enzyme/coenzyme activity (HP:0012379)1.71997494
158Nephrolithiasis (HP:0000787)1.71877545
159Generalized aminoaciduria (HP:0002909)1.71718014
160Turricephaly (HP:0000262)1.71603433
161Mixed hearing impairment (HP:0000410)1.71175908
162Aortic dissection (HP:0002647)1.71053082
163Pancreatitis (HP:0001733)1.70862691
164Lymphangioma (HP:0100764)1.70673734
165Abnormality of vitamin metabolism (HP:0100508)1.70462439
166Coronal craniosynostosis (HP:0004440)1.69133073
167Short humerus (HP:0005792)1.68850498
168Vomiting (HP:0002013)1.68818704
169Hypopigmentation of the fundus (HP:0007894)1.68574091
170Abnormality of molar (HP:0011077)1.68274043
171Abnormality of molar morphology (HP:0011070)1.68274043
172Alacrima (HP:0000522)1.68049842
173Late onset (HP:0003584)1.66522962
174Glomerulonephritis (HP:0000099)1.65716343
175Peritonitis (HP:0002586)1.65415669
176Ectopic anus (HP:0004397)1.65222145
177Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.64222281
178Hemorrhage of the eye (HP:0011885)1.63983050
179Pseudobulbar signs (HP:0002200)1.63601224
180Abnormality of the gallbladder (HP:0005264)1.63472646
181Abnormality of the Achilles tendon (HP:0005109)1.63387899
182Ulnar deviation of finger (HP:0009465)1.62600767
183Tubulointerstitial nephritis (HP:0001970)1.62103610
184Midline defect of the nose (HP:0004122)1.61538930
185Abnormal delivery (HP:0001787)1.61110119
186Cerebral edema (HP:0002181)1.60395039
187Decreased lacrimation (HP:0000633)1.59410676
188Scotoma (HP:0000575)1.58187876
189Nephroblastoma (Wilms tumor) (HP:0002667)1.58053406
190Popliteal pterygium (HP:0009756)1.57781476
191Abnormal biliary tract morphology (HP:0012440)1.57121713
192Volvulus (HP:0002580)1.56973568
193Median cleft lip (HP:0000161)1.55258156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.19490339
2OBSCN4.32053402
3SIK14.22281909
4BCKDK4.14067214
5ERBB43.55561312
6FGFR43.35305944
7ACVR1B3.00715523
8ERN12.94820307
9STK38L2.85621521
10FRK2.85351516
11PBK2.68536946
12LATS22.55600854
13MST1R2.51912957
14WEE12.33135219
15BMPR1B2.04038814
16TNIK1.98663352
17TRIB31.95768238
18NEK91.95535309
19DMPK1.72299223
20PLK41.65705688
21FER1.64863652
22EPHB21.63764289
23EPHA31.60943298
24PTK61.60904426
25PDGFRA1.60575050
26STK31.58319366
27FGFR21.55675860
28TRIM281.55022111
29STK391.53019266
30PKN21.52554316
31PNCK1.52034529
32MET1.51275195
33MAP2K41.50399352
34INSRR1.49501108
35MAPK111.47627074
36AKT31.39194433
37BRSK21.38149706
38MST41.37279416
39NUAK11.35558177
40ERBB21.34231893
41EIF2AK31.33418146
42TSSK61.30602558
43TAOK31.30540553
44NEK11.30290933
45DDR21.29649849
46BCR1.22391606
47PRKAA21.21510299
48CASK1.18437772
49MKNK21.17119782
50CDK61.14833958
51PTK21.14767759
52CAMK1D1.12831136
53EPHA21.09438369
54MAP3K61.07926748
55ABL21.04356606
56PLK31.03981463
57STK241.01126658
58MKNK10.98579301
59PIK3CG0.94167557
60MAP3K70.94104268
61TGFBR10.93086408
62NEK20.90778676
63CDC70.89357009
64PAK30.87655701
65MTOR0.83290094
66SGK20.83208072
67SGK30.82727349
68ERBB30.80441989
69RIPK10.79275553
70TIE10.78011980
71FGFR10.76751454
72PDK40.76331271
73PDK30.76331271
74PRKAA10.76199614
75YES10.75059011
76MAP3K30.74588433
77PIK3CA0.74103374
78BRD40.72108384
79WNK30.69127838
80PLK10.69108377
81TAOK20.67551838
82PRKCZ0.66201618
83GSK3A0.65012214
84PAK20.64366099
85PAK40.64076478
86SCYL20.63932238
87MYLK0.63427071
88MAP3K20.63139370
89MAP2K10.61627334
90SRPK10.61134584
91CSNK1G10.60759831
92MAP3K50.60067345
93PLK20.59771699
94MELK0.58032368
95LMTK20.57858512
96TAF10.54425411
97TTK0.53589587
98WNK40.53359159
99TYRO30.52934539
100BMX0.52804777
101FGFR30.52112005
102CAMK1G0.51836348
103MAP3K120.51256579
104NLK0.50773510
105JAK20.50373985
106ATM0.50262067
107SGK4940.49820876
108SGK2230.49820876
109EPHA40.49382301
110STK380.49094947
111PINK10.48784252
112PRKD30.47213855
113TTN0.46769327
114RET0.46117895
115PRKCE0.45578731
116ZAK0.45202709
117CAMK2G0.44794501
118OXSR10.44722595
119PDGFRB0.44687745
120DYRK30.43627795
121PDK20.42793431
122CDK30.42668560
123CSNK1A1L0.41476967
124CDK90.41287422
125IGF1R0.40794477
126JAK10.40790688
127MAP3K100.39963250
128AKT20.39567471
129CDK80.39455006
130KDR0.39300782
131EGFR0.38697259
132MAP3K40.38566725
133NEK60.38504746
134ROCK10.37804075
135FLT30.37616413
136CDK120.37170820
137CDK40.35882200
138MAPK70.35309538
139CAMK2D0.34673132
140DAPK20.34610264
141STK40.34144972
142MAP3K80.33724092
143MAPK150.33618581
144EIF2AK20.33133754
145AURKB0.32369188
146TAOK10.32050761
147KSR10.31563862
148GRK10.31560106
149PRKACG0.30713004
150DYRK1B0.30568527
151BRSK10.30544115
152TGFBR20.30124502
153MAP3K110.28462350
154MAPK40.28369182
155CHEK10.27981722
156STK100.27276175
157RPS6KA40.26870540
158CHEK20.26331964
159MAP2K20.24993141

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.27977664
2Nitrogen metabolism_Homo sapiens_hsa009103.55445074
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33120828
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.06320411
5Arginine biosynthesis_Homo sapiens_hsa002202.92322626
6Tryptophan metabolism_Homo sapiens_hsa003802.69599757
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68700635
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56344248
9Fatty acid degradation_Homo sapiens_hsa000712.55139149
10Complement and coagulation cascades_Homo sapiens_hsa046102.55101588
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50588510
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.45121856
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38801801
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23396437
15Butanoate metabolism_Homo sapiens_hsa006502.22059564
16Non-homologous end-joining_Homo sapiens_hsa034502.14272276
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10407858
18Peroxisome_Homo sapiens_hsa041462.01588963
19Propanoate metabolism_Homo sapiens_hsa006402.00684271
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.95359153
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.95304207
22PPAR signaling pathway_Homo sapiens_hsa033201.94924263
23Chemical carcinogenesis_Homo sapiens_hsa052041.90353718
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90247657
25Fatty acid metabolism_Homo sapiens_hsa012121.83373472
26Histidine metabolism_Homo sapiens_hsa003401.77714822
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.75910178
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72308742
29Dilated cardiomyopathy_Homo sapiens_hsa054141.72082469
30beta-Alanine metabolism_Homo sapiens_hsa004101.71451854
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71120691
32Retinol metabolism_Homo sapiens_hsa008301.70233097
33Tight junction_Homo sapiens_hsa045301.67156363
34Caffeine metabolism_Homo sapiens_hsa002321.61936491
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.59450255
36Bile secretion_Homo sapiens_hsa049761.56085672
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55108953
38Selenocompound metabolism_Homo sapiens_hsa004501.53033298
39Phenylalanine metabolism_Homo sapiens_hsa003601.45671844
40Sulfur metabolism_Homo sapiens_hsa009201.43853865
41Pyruvate metabolism_Homo sapiens_hsa006201.37352365
42Cell cycle_Homo sapiens_hsa041101.36645200
43Tyrosine metabolism_Homo sapiens_hsa003501.35230389
44Starch and sucrose metabolism_Homo sapiens_hsa005001.33574164
45Wnt signaling pathway_Homo sapiens_hsa043101.33479725
46Focal adhesion_Homo sapiens_hsa045101.32195697
47Mismatch repair_Homo sapiens_hsa034301.31654426
48Staphylococcus aureus infection_Homo sapiens_hsa051501.28428318
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.23381993
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.19946113
51Steroid biosynthesis_Homo sapiens_hsa001001.18319399
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17615729
53Fat digestion and absorption_Homo sapiens_hsa049751.17470314
54Vitamin digestion and absorption_Homo sapiens_hsa049771.17123574
55Biosynthesis of amino acids_Homo sapiens_hsa012301.16696763
56Folate biosynthesis_Homo sapiens_hsa007901.15424512
57Carbon metabolism_Homo sapiens_hsa012001.12248346
58Small cell lung cancer_Homo sapiens_hsa052221.11739695
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09186079
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07706283
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06422409
62Fatty acid elongation_Homo sapiens_hsa000621.05623971
63Lysine degradation_Homo sapiens_hsa003101.02701761
64Arginine and proline metabolism_Homo sapiens_hsa003301.02676815
65Vitamin B6 metabolism_Homo sapiens_hsa007501.00192871
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99767217
67MicroRNAs in cancer_Homo sapiens_hsa052060.93382645
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91325684
69ABC transporters_Homo sapiens_hsa020100.90789582
70Melanoma_Homo sapiens_hsa052180.85082801
71RNA transport_Homo sapiens_hsa030130.84523570
72Fanconi anemia pathway_Homo sapiens_hsa034600.83632453
73Glutathione metabolism_Homo sapiens_hsa004800.83574360
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.82588846
75Melanogenesis_Homo sapiens_hsa049160.82434215
76Thyroid cancer_Homo sapiens_hsa052160.82388637
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82266758
78p53 signaling pathway_Homo sapiens_hsa041150.77138752
79Sulfur relay system_Homo sapiens_hsa041220.76292323
80Pathways in cancer_Homo sapiens_hsa052000.75996904
81Fatty acid biosynthesis_Homo sapiens_hsa000610.73050978
82Prostate cancer_Homo sapiens_hsa052150.72287042
83One carbon pool by folate_Homo sapiens_hsa006700.70939242
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70105546
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70063399
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70059340
87DNA replication_Homo sapiens_hsa030300.69845802
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68810784
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68781824
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67378249
91Oocyte meiosis_Homo sapiens_hsa041140.64622130
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64022619
93Glycerolipid metabolism_Homo sapiens_hsa005610.61809922
94mRNA surveillance pathway_Homo sapiens_hsa030150.61729842
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60594656
96Basal transcription factors_Homo sapiens_hsa030220.60034556
97Homologous recombination_Homo sapiens_hsa034400.58235969
98Sphingolipid metabolism_Homo sapiens_hsa006000.57691680
99Nucleotide excision repair_Homo sapiens_hsa034200.56115563
100Colorectal cancer_Homo sapiens_hsa052100.53310461
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51194567
102Pentose phosphate pathway_Homo sapiens_hsa000300.49836651
103Axon guidance_Homo sapiens_hsa043600.47513846
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38849033
105Metabolic pathways_Homo sapiens_hsa011000.38201300
106Insulin resistance_Homo sapiens_hsa049310.32053233
107Prion diseases_Homo sapiens_hsa050200.28965985
108Linoleic acid metabolism_Homo sapiens_hsa005910.27113953
109Galactose metabolism_Homo sapiens_hsa000520.25257980
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.22299200
111Ovarian steroidogenesis_Homo sapiens_hsa049130.21031027
112Fructose and mannose metabolism_Homo sapiens_hsa000510.17497340
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.16673321
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15935548
115Glucagon signaling pathway_Homo sapiens_hsa049220.15758764
116Basal cell carcinoma_Homo sapiens_hsa052170.14626945
117AMPK signaling pathway_Homo sapiens_hsa041520.12943037
118Protein digestion and absorption_Homo sapiens_hsa049740.12241805
119ECM-receptor interaction_Homo sapiens_hsa045120.11692927
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.10732873
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.10175767
122Bladder cancer_Homo sapiens_hsa052190.09802110
123Adherens junction_Homo sapiens_hsa045200.09532624
124Renin-angiotensin system_Homo sapiens_hsa046140.08185553
125TGF-beta signaling pathway_Homo sapiens_hsa043500.06302224
126Mineral absorption_Homo sapiens_hsa049780.03388372
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.02595888
128Hippo signaling pathway_Homo sapiens_hsa043900.01589402
129Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0749480
130Proteoglycans in cancer_Homo sapiens_hsa05205-0.0632056
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0512526
132Hedgehog signaling pathway_Homo sapiens_hsa04340-0.0328803
133Circadian rhythm_Homo sapiens_hsa04710-0.0277378
134Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0258566
135Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0196686
136Insulin signaling pathway_Homo sapiens_hsa04910-0.0181978
137Amoebiasis_Homo sapiens_hsa05146-0.0086256

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