ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.13583343
2	DNA deamination (GO:0045006)	4.75131931
3	L-fucose catabolic process (GO:0042355)	4.52237096
4	fucose catabolic process (GO:0019317)	4.52237096
5	L-fucose metabolic process (GO:0042354)	4.52237096
6	indolalkylamine metabolic process (GO:0006586)	4.51743260
7	response to pheromone (GO:0019236)	4.36693124
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.03851041
9	NADH dehydrogenase complex assembly (GO:0010257)	4.03851041
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.03851041
11	tryptophan catabolic process (GO:0006569)	4.03234125
12	indole-containing compound catabolic process (GO:0042436)	4.03234125
13	indolalkylamine catabolic process (GO:0046218)	4.03234125
14	protein complex biogenesis (GO:0070271)	4.01630201
15	protein polyglutamylation (GO:0018095)	3.92763064
16	platelet dense granule organization (GO:0060155)	3.85255284
17	protein-cofactor linkage (GO:0018065)	3.84053215
18	epithelial cilium movement (GO:0003351)	3.83145182
19	serotonin metabolic process (GO:0042428)	3.76990937
20	indole-containing compound metabolic process (GO:0042430)	3.68408369
21	axoneme assembly (GO:0035082)	3.59657459
22	mitochondrial respiratory chain complex assembly (GO:0033108)	3.58012322
23	primary amino compound metabolic process (GO:1901160)	3.57397506
24	respiratory chain complex IV assembly (GO:0008535)	3.54946204
25	piRNA metabolic process (GO:0034587)	3.52129322
26	kynurenine metabolic process (GO:0070189)	3.51011836
27	tryptophan metabolic process (GO:0006568)	3.43129993
28	negative regulation of telomere maintenance (GO:0032205)	3.41380225
29	cellular ketone body metabolic process (GO:0046950)	3.34774463
30	ubiquinone biosynthetic process (GO:0006744)	3.34769046
31	water-soluble vitamin biosynthetic process (GO:0042364)	3.34290620
32	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.30341776
33	cAMP catabolic process (GO:0006198)	3.17928517
34	cytochrome complex assembly (GO:0017004)	3.15403660
35	cilium movement (GO:0003341)	3.07184557
36	ubiquinone metabolic process (GO:0006743)	3.06101105
37	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.05263364
38	gamma-aminobutyric acid transport (GO:0015812)	3.01062785
39	DNA methylation involved in gamete generation (GO:0043046)	2.98184248
40	regulation of cilium movement (GO:0003352)	2.94942513
41	adaptation of signaling pathway (GO:0023058)	2.94277113
42	lactate metabolic process (GO:0006089)	2.94018896
43	preassembly of GPI anchor in ER membrane (GO:0016254)	2.93242329
44	ketone body metabolic process (GO:1902224)	2.92881076
45	regulation of telomere maintenance (GO:0032204)	2.91381028
46	nonmotile primary cilium assembly (GO:0035058)	2.90334465
47	regulation of neurotransmitter uptake (GO:0051580)	2.85128258
48	rRNA modification (GO:0000154)	2.84578327
49	cyclic nucleotide catabolic process (GO:0009214)	2.83386047
50	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.82231665
51	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.78325203
52	protein K11-linked deubiquitination (GO:0035871)	2.77694299
53	spinal cord motor neuron differentiation (GO:0021522)	2.77152416
54	replication fork processing (GO:0031297)	2.76940549
55	neuronal action potential (GO:0019228)	2.75033028
56	cellular biogenic amine catabolic process (GO:0042402)	2.74259146
57	amine catabolic process (GO:0009310)	2.74259146
58	glycerophospholipid catabolic process (GO:0046475)	2.71863725
59	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.69849698
60	cilium morphogenesis (GO:0060271)	2.69696794
61	rhodopsin mediated signaling pathway (GO:0016056)	2.69679846
62	behavioral response to ethanol (GO:0048149)	2.69438428
63	S-adenosylmethionine metabolic process (GO:0046500)	2.67377145
64	reflex (GO:0060004)	2.67103043
65	pyrimidine nucleobase catabolic process (GO:0006208)	2.67048483
66	pseudouridine synthesis (GO:0001522)	2.67032277
67	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.65776946
68	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.65776946
69	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.63775253
70	quinone biosynthetic process (GO:1901663)	2.63640287
71	multicellular organism reproduction (GO:0032504)	2.63398655
72	regulation of mesoderm development (GO:2000380)	2.62660119
73	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.60681125
74	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.60388471
75	rRNA methylation (GO:0031167)	2.60370462
76	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.58542999
77	cilium organization (GO:0044782)	2.58457581
78	GPI anchor metabolic process (GO:0006505)	2.54567465
79	regulation of action potential (GO:0098900)	2.54157959
80	cilium assembly (GO:0042384)	2.54034420
81	retinal cone cell development (GO:0046549)	2.52957985
82	cytidine deamination (GO:0009972)	2.52677475
83	cytidine metabolic process (GO:0046087)	2.52677475
84	cytidine catabolic process (GO:0006216)	2.52677475
85	sulfation (GO:0051923)	2.52193945
86	synaptic transmission, cholinergic (GO:0007271)	2.51940148
87	cilium or flagellum-dependent cell motility (GO:0001539)	2.51233731
88	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.50504768
89	detection of light stimulus involved in sensory perception (GO:0050962)	2.47876906
90	detection of light stimulus involved in visual perception (GO:0050908)	2.47876906
91	mannosylation (GO:0097502)	2.46447729
92	aromatic amino acid family catabolic process (GO:0009074)	2.46237259
93	maturation of 5.8S rRNA (GO:0000460)	2.46084147
94	dopamine transport (GO:0015872)	2.45746361
95	peptidyl-histidine modification (GO:0018202)	2.42265614
96	positive regulation of mitochondrial fission (GO:0090141)	2.40753589
97	positive regulation of defense response to virus by host (GO:0002230)	2.39707057
98	L-methionine salvage (GO:0071267)	2.37972196
99	L-methionine biosynthetic process (GO:0071265)	2.37972196
100	amino acid salvage (GO:0043102)	2.37972196

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.92380201
2	VDR_22108803_ChIP-Seq_LS180_Human	3.16182934
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.96252316
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.87314509
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.75439420
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.68806675
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.49460297
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.48280431
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.38984811
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.24856079
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.21570415
12	FUS_26573619_Chip-Seq_HEK293_Human	2.12862980
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.08736927
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.02975807
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.00503532
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.98053599
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.95883485
18	P300_19829295_ChIP-Seq_ESCs_Human	1.93456256
19	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.92782875
20	EWS_26573619_Chip-Seq_HEK293_Human	1.88569575
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.84261100
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.78886020
23	EZH2_22144423_ChIP-Seq_EOC_Human	1.77603852
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.75275707
25	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.74067880
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.73989506
27	ER_23166858_ChIP-Seq_MCF-7_Human	1.73557610
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.68837983
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.63081577
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.61959546
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.55747896
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54559695
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.54559695
34	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.51724625
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.48384602
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48245669
37	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.46269094
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.42995214
39	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.42944820
40	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.42154692
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.40956397
42	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.39988274
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.39988274
44	VDR_23849224_ChIP-Seq_CD4+_Human	1.38397793
45	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.33957097
46	SMAD4_21799915_ChIP-Seq_A2780_Human	1.33956546
47	TCF4_22108803_ChIP-Seq_LS180_Human	1.33654949
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30944571
49	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.30874954
50	REST_21632747_ChIP-Seq_MESCs_Mouse	1.30619517
51	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.28863968
52	ELK1_19687146_ChIP-ChIP_HELA_Human	1.28615480
53	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28602330
54	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.28396776
55	STAT3_23295773_ChIP-Seq_U87_Human	1.28364634
56	TCF4_23295773_ChIP-Seq_U87_Human	1.28340661
57	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.27851246
58	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27851246
59	AR_25329375_ChIP-Seq_VCAP_Human	1.27196234
60	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.26848357
61	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.24696638
62	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.24650085
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22378738
64	AR_20517297_ChIP-Seq_VCAP_Human	1.22058031
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20676504
66	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.20566402
67	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.20268773
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.19544095
69	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.19475468
70	NCOR_22424771_ChIP-Seq_293T_Human	1.18596473
71	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.18251884
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18069958
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18069958
74	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.15207005
75	HOXB7_26014856_ChIP-Seq_BT474_Human	1.15157768
76	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14955270
77	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.14412199
78	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13470335
79	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.13216362
80	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.12721906
81	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.11652518
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.11398164
83	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.11393284
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10823043
85	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.10260135
86	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.09245949
87	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.05332187
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05271179
89	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.05257169
90	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.04721524
91	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04295147
92	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00873162
93	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00539094
94	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99934203
95	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99425274
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98773894
97	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97854102
98	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97508480
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97298652
100	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96780322

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	3.17961381
2	MP0003787_abnormal_imprinting	3.05572826
3	MP0000569_abnormal_digit_pigmentation	2.95572761
4	MP0002653_abnormal_ependyma_morphology	2.65263644
5	MP0001986_abnormal_taste_sensitivity	2.54248330
6	MP0005551_abnormal_eye_electrophysiolog	2.52625255
7	MP0008877_abnormal_DNA_methylation	2.42645787
8	MP0002876_abnormal_thyroid_physiology	2.33397916
9	MP0002638_abnormal_pupillary_reflex	2.21312609
10	MP0002234_abnormal_pharynx_morphology	2.19035555
11	MP0001968_abnormal_touch/_nociception	2.16562415
12	MP0006072_abnormal_retinal_apoptosis	2.16297891
13	MP0009046_muscle_twitch	2.11398490
14	MP0004147_increased_porphyrin_level	2.10878552
15	MP0002102_abnormal_ear_morphology	2.09321894
16	MP0006276_abnormal_autonomic_nervous	2.00567360
17	MP0008875_abnormal_xenobiotic_pharmacok	1.92761029
18	MP0002736_abnormal_nociception_after	1.92546143
19	MP0004142_abnormal_muscle_tone	1.90745160
20	MP0009745_abnormal_behavioral_response	1.90243697
21	MP0005645_abnormal_hypothalamus_physiol	1.90184960
22	MP0006292_abnormal_olfactory_placode	1.89966220
23	MP0004043_abnormal_pH_regulation	1.84927468
24	MP0003880_abnormal_central_pattern	1.81571952
25	MP0003195_calcinosis	1.78785798
26	MP0005253_abnormal_eye_physiology	1.77235991
27	MP0003646_muscle_fatigue	1.70476948
28	MP0008872_abnormal_physiological_respon	1.67773177
29	MP0001501_abnormal_sleep_pattern	1.63177021
30	MP0001984_abnormal_olfaction	1.58134087
31	MP0002938_white_spotting	1.57165614
32	MP0001486_abnormal_startle_reflex	1.54201129
33	MP0005646_abnormal_pituitary_gland	1.53032593
34	MP0000631_abnormal_neuroendocrine_gland	1.51549360
35	MP0001529_abnormal_vocalization	1.50151594
36	MP0002735_abnormal_chemical_nociception	1.48500898
37	MP0001764_abnormal_homeostasis	1.45171239
38	MP0002272_abnormal_nervous_system	1.42247640
39	MP0003121_genomic_imprinting	1.40554965
40	MP0001485_abnormal_pinna_reflex	1.39033413
41	MP0002572_abnormal_emotion/affect_behav	1.31440093
42	MP0008058_abnormal_DNA_repair	1.25744491
43	MP0004885_abnormal_endolymph	1.25382146
44	MP0001905_abnormal_dopamine_level	1.24774567
45	MP0005423_abnormal_somatic_nervous	1.24406498
46	MP0005389_reproductive_system_phenotype	1.24029657
47	MP0000427_abnormal_hair_cycle	1.23561250
48	MP0000372_irregular_coat_pigmentation	1.21623736
49	MP0008789_abnormal_olfactory_epithelium	1.21014239
50	MP0004924_abnormal_behavior	1.19989982
51	MP0005386_behavior/neurological_phenoty	1.19989982
52	MP0002064_seizures	1.19986318
53	MP0008995_early_reproductive_senescence	1.19456282
54	MP0004133_heterotaxia	1.17803199
55	MP0005379_endocrine/exocrine_gland_phen	1.17625322
56	MP0008775_abnormal_heart_ventricle	1.16988596
57	MP0002557_abnormal_social/conspecific_i	1.15239912
58	MP0002733_abnormal_thermal_nociception	1.13262938
59	MP0002751_abnormal_autonomic_nervous	1.12828613
60	MP0001970_abnormal_pain_threshold	1.10497664
61	MP0002693_abnormal_pancreas_physiology	1.10129635
62	MP0003011_delayed_dark_adaptation	1.09631595
63	MP0001919_abnormal_reproductive_system	1.08683323
64	MP0002160_abnormal_reproductive_system	1.07247361
65	MP0004145_abnormal_muscle_electrophysio	1.05586341
66	MP0002163_abnormal_gland_morphology	1.04038062
67	MP0002138_abnormal_hepatobiliary_system	1.02787236
68	MP0004215_abnormal_myocardial_fiber	1.01647012
69	MP0005410_abnormal_fertilization	1.01333278
70	MP0005195_abnormal_posterior_eye	1.00998362
71	MP0001873_stomach_inflammation	0.99605457
72	MP0010386_abnormal_urinary_bladder	0.95909535
73	MP0003718_maternal_effect	0.93959144
74	MP0005332_abnormal_amino_acid	0.92134989
75	MP0002822_catalepsy	0.90924667
76	MP0005084_abnormal_gallbladder_morpholo	0.90568173
77	MP0002067_abnormal_sensory_capabilities	0.89866423
78	MP0002734_abnormal_mechanical_nocicepti	0.88453713
79	MP0002063_abnormal_learning/memory/cond	0.88124485
80	MP0003635_abnormal_synaptic_transmissio	0.87789274
81	MP0002229_neurodegeneration	0.87686916
82	MP0003122_maternal_imprinting	0.85794761
83	MP0002752_abnormal_somatic_nervous	0.85740467
84	MP0000230_abnormal_systemic_arterial	0.85528337
85	MP0002095_abnormal_skin_pigmentation	0.85305927
86	MP0003186_abnormal_redox_activity	0.85172795
87	MP0002184_abnormal_innervation	0.81167227
88	MP0003698_abnormal_male_reproductive	0.80999770
89	MP0004085_abnormal_heartbeat	0.80160089
90	MP0005448_abnormal_energy_balance	0.78713142
91	MP0001944_abnormal_pancreas_morphology	0.76895642
92	MP0000647_abnormal_sebaceous_gland	0.74827352
93	MP0001929_abnormal_gametogenesis	0.74105724
94	MP0005499_abnormal_olfactory_system	0.73339783
95	MP0005394_taste/olfaction_phenotype	0.73339783
96	MP0005174_abnormal_tail_pigmentation	0.73194496
97	MP0004742_abnormal_vestibular_system	0.73031678
98	MP0002909_abnormal_adrenal_gland	0.72668695
99	MP0003786_premature_aging	0.72366593
100	MP0000516_abnormal_urinary_system	0.70059837

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.47140722
2	Abnormality of midbrain morphology (HP:0002418)	4.05267563
3	Molar tooth sign on MRI (HP:0002419)	4.05267563
4	True hermaphroditism (HP:0010459)	4.03675290
5	Pancreatic fibrosis (HP:0100732)	4.00060718
6	Congenital stationary night blindness (HP:0007642)	3.72970387
7	Nephronophthisis (HP:0000090)	3.37936796
8	Chronic hepatic failure (HP:0100626)	3.22419625
9	Medial flaring of the eyebrow (HP:0010747)	3.17345692
10	Type II lissencephaly (HP:0007260)	3.03637766
11	Acute necrotizing encephalopathy (HP:0006965)	2.83121372
12	Abnormal rod and cone electroretinograms (HP:0008323)	2.82540478
13	Abnormality of alanine metabolism (HP:0010916)	2.79956777
14	Hyperalaninemia (HP:0003348)	2.79956777
15	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.79956777
16	Abnormality of the renal medulla (HP:0100957)	2.77265585
17	Cystic liver disease (HP:0006706)	2.73982310
18	Abolished electroretinogram (ERG) (HP:0000550)	2.71504895
19	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.70569386
20	Absent/shortened dynein arms (HP:0200106)	2.70569386
21	Increased CSF lactate (HP:0002490)	2.65450463
22	Mitochondrial inheritance (HP:0001427)	2.62230942
23	Pendular nystagmus (HP:0012043)	2.61520087
24	Progressive inability to walk (HP:0002505)	2.58303198
25	Progressive macrocephaly (HP:0004481)	2.49480248
26	Attenuation of retinal blood vessels (HP:0007843)	2.49374200
27	Abnormal drinking behavior (HP:0030082)	2.46808720
28	Polydipsia (HP:0001959)	2.46808720
29	Gait imbalance (HP:0002141)	2.46728292
30	Decreased circulating renin level (HP:0003351)	2.46602073
31	Abnormality of the renal cortex (HP:0011035)	2.43332824
32	Inability to walk (HP:0002540)	2.43094104
33	Acute encephalopathy (HP:0006846)	2.42335492
34	Congenital primary aphakia (HP:0007707)	2.41718292
35	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.40497583
36	Abnormal mitochondria in muscle tissue (HP:0008316)	2.39185245
37	Abnormal respiratory motile cilium morphology (HP:0005938)	2.35213700
38	Abnormal respiratory epithelium morphology (HP:0012253)	2.35213700
39	Nephrogenic diabetes insipidus (HP:0009806)	2.30478406
40	Severe muscular hypotonia (HP:0006829)	2.28529010
41	Broad-based gait (HP:0002136)	2.28462967
42	Thyroiditis (HP:0100646)	2.27868492
43	Tubular atrophy (HP:0000092)	2.25027853
44	Hepatocellular necrosis (HP:0001404)	2.24619765
45	Epileptic encephalopathy (HP:0200134)	2.22798093
46	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.19901205
47	Hyperventilation (HP:0002883)	2.19082248
48	Abnormal ciliary motility (HP:0012262)	2.17686221
49	Hypothermia (HP:0002045)	2.17423902
50	Hepatic necrosis (HP:0002605)	2.15990177
51	Severe combined immunodeficiency (HP:0004430)	2.15601840
52	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.13392369
53	Sclerocornea (HP:0000647)	2.10492990
54	Male pseudohermaphroditism (HP:0000037)	2.08440435
55	Gaze-evoked nystagmus (HP:0000640)	2.07549683
56	Furrowed tongue (HP:0000221)	2.06519384
57	Abnormal respiratory motile cilium physiology (HP:0012261)	2.05016543
58	Anencephaly (HP:0002323)	2.04795351
59	Intestinal atresia (HP:0011100)	2.03321651
60	Constricted visual fields (HP:0001133)	2.03319790
61	Lissencephaly (HP:0001339)	2.02733807
62	Abnormal biliary tract physiology (HP:0012439)	2.02702539
63	Bile duct proliferation (HP:0001408)	2.02702539
64	Hemiparesis (HP:0001269)	2.01234932
65	Abnormality of the labia minora (HP:0012880)	1.96859662
66	Short tibia (HP:0005736)	1.95971346
67	Ketoacidosis (HP:0001993)	1.95532227
68	Postaxial foot polydactyly (HP:0001830)	1.94991997
69	Optic disc pallor (HP:0000543)	1.93759722
70	Polyuria (HP:0000103)	1.93047102
71	Large for gestational age (HP:0001520)	1.91503064
72	Methylmalonic acidemia (HP:0002912)	1.90022463
73	Febrile seizures (HP:0002373)	1.89581927
74	Hypoproteinemia (HP:0003075)	1.89254040
75	Bony spicule pigmentary retinopathy (HP:0007737)	1.89191683
76	Increased corneal curvature (HP:0100692)	1.87535594
77	Keratoconus (HP:0000563)	1.87535594
78	Genital tract atresia (HP:0001827)	1.87265067
79	Congenital, generalized hypertrichosis (HP:0004540)	1.86920933
80	Ketosis (HP:0001946)	1.86869700
81	Optic nerve hypoplasia (HP:0000609)	1.84946500
82	Drooling (HP:0002307)	1.84761542
83	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.83239159
84	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.83239159
85	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.82880615
86	Increased serum lactate (HP:0002151)	1.82119780
87	Abnormality of the pons (HP:0007361)	1.81146992
88	Vaginal atresia (HP:0000148)	1.79891740
89	Abnormality of the renal collecting system (HP:0004742)	1.79287766
90	Duplicated collecting system (HP:0000081)	1.78245334
91	Congenital hepatic fibrosis (HP:0002612)	1.78181364
92	Lactic acidosis (HP:0003128)	1.77265235
93	IgG deficiency (HP:0004315)	1.76887936
94	Renal cortical cysts (HP:0000803)	1.75886206
95	Methylmalonic aciduria (HP:0012120)	1.75767873
96	Cerebellar dysplasia (HP:0007033)	1.74249811
97	Lipid accumulation in hepatocytes (HP:0006561)	1.74229668
98	Cerebral edema (HP:0002181)	1.74105873
99	Disproportionate short-trunk short stature (HP:0003521)	1.72242372
100	Occipital encephalocele (HP:0002085)	1.71963377

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.28218914
2	MAP4K2	4.25680009
3	TLK1	3.71839337
4	BMPR1B	3.11950848
5	ACVR1B	3.09631724
6	ADRBK2	3.03538723
7	WNK3	2.60851740
8	NUAK1	2.27653321
9	GRK1	2.18783442
10	CASK	2.15257113
11	OXSR1	2.09680421
12	PINK1	2.02122049
13	ZAK	1.93007740
14	WNK4	1.93004250
15	TXK	1.78272117
16	TAOK3	1.77432468
17	PIK3CA	1.76778337
18	CAMKK2	1.72292834
19	MAPK13	1.66990793
20	STK39	1.49284324
21	INSRR	1.47105996
22	MAP3K4	1.46882708
23	EIF2AK3	1.44017729
24	TIE1	1.39611399
25	PAK3	1.30860893
26	MKNK2	1.20046927
27	CDK19	1.19536846
28	MST4	1.18989442
29	STK16	1.14994061
30	TEC	1.14349704
31	MAP2K7	1.12498136
32	DYRK2	1.12472485
33	DAPK2	1.10667591
34	STK38L	1.05673550
35	PHKG2	1.01673515
36	PHKG1	1.01673515
37	PRKCG	0.99291785
38	PASK	0.97394420
39	BCKDK	0.96419232
40	TGFBR1	0.90829581
41	CSNK1G1	0.86641441
42	PRKCE	0.86294449
43	ADRBK1	0.84977865
44	CSNK1G3	0.84282931
45	TRIM28	0.82746622
46	CSNK1G2	0.78812811
47	CSNK1A1L	0.78016315
48	MAP2K6	0.76291851
49	MARK1	0.75783629
50	SIK2	0.75074167
51	CAMK1D	0.73384369
52	PLK2	0.73272793
53	MUSK	0.70907951
54	CAMKK1	0.68322249
55	TSSK6	0.66334070
56	PTK2B	0.65181597
57	GRK7	0.64283319
58	VRK1	0.64168881
59	BRSK2	0.63437499
60	IRAK1	0.62992130
61	PRKCQ	0.61629614
62	ERBB3	0.59923469
63	FLT3	0.59117810
64	KIT	0.57572753
65	TNIK	0.57448963
66	ITK	0.56616104
67	NTRK3	0.54491464
68	NLK	0.53783040
69	CAMK2A	0.53339037
70	BCR	0.53136520
71	IKBKB	0.52549696
72	MKNK1	0.52535502
73	STK11	0.50377578
74	EPHA4	0.48744628
75	RPS6KA5	0.47150019
76	MARK3	0.44239579
77	LIMK1	0.42869257
78	SRPK1	0.42445511
79	PDK2	0.42169089
80	EPHA3	0.41529845
81	PAK6	0.40041028
82	CAMK1G	0.39587420
83	PRKACA	0.39529158
84	CAMK1	0.39328326
85	FER	0.36903396
86	ERBB2	0.36496741
87	MAPKAPK3	0.36071060
88	PRKCI	0.35825276
89	PRKCZ	0.35769214
90	GRK5	0.34776665
91	MAPKAPK5	0.34743552
92	NTRK2	0.34475861
93	PLK3	0.33045196
94	PIM2	0.32989636
95	FGFR2	0.32857917
96	VRK2	0.32820276
97	CSNK1A1	0.30311253
98	PRKCA	0.29791267
99	DYRK1A	0.29482919
100	PRKAA1	0.28415498

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.96176280
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.70969907
3	Protein export_Homo sapiens_hsa03060	2.59343367
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.57971916
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.56724507
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.44597138
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.38007550
8	RNA polymerase_Homo sapiens_hsa03020	2.23636831
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.19190516
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.19063620
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.14343322
12	Caffeine metabolism_Homo sapiens_hsa00232	2.13232768
13	Parkinsons disease_Homo sapiens_hsa05012	2.05511937
14	Tryptophan metabolism_Homo sapiens_hsa00380	2.02973034
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.01463286
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.92690558
17	Butanoate metabolism_Homo sapiens_hsa00650	1.88854973
18	Nicotine addiction_Homo sapiens_hsa05033	1.83786134
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.81518256
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.80070984
21	Basal transcription factors_Homo sapiens_hsa03022	1.72408949
22	Homologous recombination_Homo sapiens_hsa03440	1.52062202
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.50372440
24	Morphine addiction_Homo sapiens_hsa05032	1.49766662
25	RNA degradation_Homo sapiens_hsa03018	1.47684691
26	Huntingtons disease_Homo sapiens_hsa05016	1.46573742
27	Propanoate metabolism_Homo sapiens_hsa00640	1.44747348
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.44010183
29	Primary immunodeficiency_Homo sapiens_hsa05340	1.42414344
30	Olfactory transduction_Homo sapiens_hsa04740	1.42167901
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.38885611
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.30758084
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.29955604
34	Collecting duct acid secretion_Homo sapiens_hsa04966	1.25421772
35	Taste transduction_Homo sapiens_hsa04742	1.21374987
36	Proteasome_Homo sapiens_hsa03050	1.21210679
37	Alzheimers disease_Homo sapiens_hsa05010	1.20629724
38	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.16901800
39	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.15719312
40	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.15581038
41	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.15416723
42	GABAergic synapse_Homo sapiens_hsa04727	1.15166563
43	One carbon pool by folate_Homo sapiens_hsa00670	1.13949344
44	Chemical carcinogenesis_Homo sapiens_hsa05204	1.09188452
45	Type I diabetes mellitus_Homo sapiens_hsa04940	1.08686447
46	Peroxisome_Homo sapiens_hsa04146	1.08405808
47	Sulfur metabolism_Homo sapiens_hsa00920	1.07591079
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.03700448
49	Cardiac muscle contraction_Homo sapiens_hsa04260	1.01439879
50	Regulation of autophagy_Homo sapiens_hsa04140	1.00696885
51	Retinol metabolism_Homo sapiens_hsa00830	0.96998184
52	Purine metabolism_Homo sapiens_hsa00230	0.96723357
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93643250
54	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.93597472
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.92504913
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.90405130
57	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.89070393
58	Insulin secretion_Homo sapiens_hsa04911	0.85978383
59	Fatty acid elongation_Homo sapiens_hsa00062	0.85316388
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.83689978
61	Serotonergic synapse_Homo sapiens_hsa04726	0.78646009
62	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.77911828
63	Circadian entrainment_Homo sapiens_hsa04713	0.76091159
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.73934714
65	ABC transporters_Homo sapiens_hsa02010	0.72665568
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.72110702
67	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71270140
68	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.71123414
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.70012645
70	Metabolic pathways_Homo sapiens_hsa01100	0.68959460
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67591401
72	Pyrimidine metabolism_Homo sapiens_hsa00240	0.65227868
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.64492205
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62013395
75	Non-homologous end-joining_Homo sapiens_hsa03450	0.61490030
76	Graft-versus-host disease_Homo sapiens_hsa05332	0.61463457
77	Fat digestion and absorption_Homo sapiens_hsa04975	0.56651392
78	Nucleotide excision repair_Homo sapiens_hsa03420	0.53423359
79	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.52400361
80	Ribosome_Homo sapiens_hsa03010	0.52151228
81	Circadian rhythm_Homo sapiens_hsa04710	0.50332175
82	Dopaminergic synapse_Homo sapiens_hsa04728	0.50325410
83	Fatty acid metabolism_Homo sapiens_hsa01212	0.50273815
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46171012
85	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.45945334
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.44392060
87	Sulfur relay system_Homo sapiens_hsa04122	0.42618127
88	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.41717770
89	Allograft rejection_Homo sapiens_hsa05330	0.40971686
90	Rheumatoid arthritis_Homo sapiens_hsa05323	0.39929944
91	Pyruvate metabolism_Homo sapiens_hsa00620	0.39034322
92	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.38459398
93	Salivary secretion_Homo sapiens_hsa04970	0.35696989
94	RNA transport_Homo sapiens_hsa03013	0.35183998
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.33957711
96	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.33934282
97	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.32080960
98	Glutathione metabolism_Homo sapiens_hsa00480	0.29585900
99	Mineral absorption_Homo sapiens_hsa04978	0.29281410
100	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.28897636

ARHGAP42P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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