ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.71614018
2	cullin deneddylation (GO:0010388)	4.30537896
3	L-fucose catabolic process (GO:0042355)	4.30453307
4	fucose catabolic process (GO:0019317)	4.30453307
5	L-fucose metabolic process (GO:0042354)	4.30453307
6	water-soluble vitamin biosynthetic process (GO:0042364)	4.30439898
7	protein deneddylation (GO:0000338)	4.26889243
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.09171806
9	NADH dehydrogenase complex assembly (GO:0010257)	4.09171806
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.09171806
11	protein-cofactor linkage (GO:0018065)	4.02450563
12	protein complex biogenesis (GO:0070271)	4.00009509
13	response to pheromone (GO:0019236)	3.84785919
14	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.83918974
15	platelet dense granule organization (GO:0060155)	3.83084123
16	mitochondrial respiratory chain complex assembly (GO:0033108)	3.81792481
17	cellular ketone body metabolic process (GO:0046950)	3.72680550
18	kynurenine metabolic process (GO:0070189)	3.59295166
19	DNA deamination (GO:0045006)	3.58002368
20	indolalkylamine metabolic process (GO:0006586)	3.55957088
21	negative regulation of telomere maintenance (GO:0032205)	3.55557843
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.52871752
23	indole-containing compound catabolic process (GO:0042436)	3.52048509
24	indolalkylamine catabolic process (GO:0046218)	3.52048509
25	tryptophan catabolic process (GO:0006569)	3.52048509
26	ketone body metabolic process (GO:1902224)	3.51067642
27	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.47904043
28	epithelial cilium movement (GO:0003351)	3.44550346
29	pseudouridine synthesis (GO:0001522)	3.27047280
30	nephron tubule morphogenesis (GO:0072078)	3.22294780
31	nephron epithelium morphogenesis (GO:0072088)	3.22294780
32	protein K11-linked deubiquitination (GO:0035871)	3.21935433
33	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.19028373
34	preassembly of GPI anchor in ER membrane (GO:0016254)	3.12363058
35	ubiquinone biosynthetic process (GO:0006744)	3.11990896
36	tryptophan metabolic process (GO:0006568)	3.10712587
37	axoneme assembly (GO:0035082)	3.01424072
38	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.97950734
39	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.96997761
40	respiratory chain complex IV assembly (GO:0008535)	2.96417176
41	auditory receptor cell stereocilium organization (GO:0060088)	2.93302490
42	ubiquinone metabolic process (GO:0006743)	2.92671860
43	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.92658957
44	ATP synthesis coupled proton transport (GO:0015986)	2.92658957
45	protein neddylation (GO:0045116)	2.92636673
46	kidney morphogenesis (GO:0060993)	2.92340330
47	detection of light stimulus involved in sensory perception (GO:0050962)	2.92072792
48	detection of light stimulus involved in visual perception (GO:0050908)	2.92072792
49	cornea development in camera-type eye (GO:0061303)	2.91195778
50	mannosylation (GO:0097502)	2.89403220
51	tRNA processing (GO:0008033)	2.86770379
52	regulation of mesoderm development (GO:2000380)	2.84216030
53	peptidyl-histidine modification (GO:0018202)	2.83740387
54	regulation of glucokinase activity (GO:0033131)	2.83721882
55	regulation of hexokinase activity (GO:1903299)	2.83721882
56	tRNA modification (GO:0006400)	2.80656897
57	positive regulation of fatty acid transport (GO:2000193)	2.77459478
58	fucosylation (GO:0036065)	2.76619823
59	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.73070954
60	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.73070954
61	piRNA metabolic process (GO:0034587)	2.72396470
62	neuronal action potential (GO:0019228)	2.72275603
63	electron transport chain (GO:0022900)	2.71859470
64	positive regulation of prostaglandin secretion (GO:0032308)	2.71744385
65	cytochrome complex assembly (GO:0017004)	2.71228899
66	cilium morphogenesis (GO:0060271)	2.70497479
67	amino acid salvage (GO:0043102)	2.68800593
68	L-methionine salvage (GO:0071267)	2.68800593
69	L-methionine biosynthetic process (GO:0071265)	2.68800593
70	cilium movement (GO:0003341)	2.67810334
71	GPI anchor metabolic process (GO:0006505)	2.65332663
72	nonmotile primary cilium assembly (GO:0035058)	2.64557943
73	indole-containing compound metabolic process (GO:0042430)	2.63855291
74	respiratory electron transport chain (GO:0022904)	2.62558755
75	parturition (GO:0007567)	2.61839280
76	behavioral response to ethanol (GO:0048149)	2.61565594
77	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.56533606
78	termination of RNA polymerase III transcription (GO:0006386)	2.56533606
79	amine catabolic process (GO:0009310)	2.52708145
80	cellular biogenic amine catabolic process (GO:0042402)	2.52708145
81	S-adenosylmethionine metabolic process (GO:0046500)	2.51767400
82	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.51710373
83	inner ear receptor stereocilium organization (GO:0060122)	2.50639955
84	quinone biosynthetic process (GO:1901663)	2.50279237
85	rhodopsin mediated signaling pathway (GO:0016056)	2.49367725
86	protein K6-linked ubiquitination (GO:0085020)	2.49266111
87	C4-dicarboxylate transport (GO:0015740)	2.47557756
88	neural tube formation (GO:0001841)	2.46257701
89	DNA damage response, detection of DNA damage (GO:0042769)	2.46100727
90	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.44146128
91	photoreceptor cell maintenance (GO:0045494)	2.42915845
92	basic amino acid transport (GO:0015802)	2.42043286
93	proline transport (GO:0015824)	2.41962663
94	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.40846438
95	proteasome assembly (GO:0043248)	2.40801234
96	regulation of cilium movement (GO:0003352)	2.40214035
97	regulation of neurotransmitter uptake (GO:0051580)	2.39991644
98	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.39320894
99	protein prenylation (GO:0018342)	2.38619979
100	prenylation (GO:0097354)	2.38619979

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.00298678
2	VDR_22108803_ChIP-Seq_LS180_Human	3.49659154
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.77306323
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.74320254
5	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.43195065
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.38701731
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.37243405
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.34010575
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.21237035
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.21007608
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.16898401
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14699103
13	EWS_26573619_Chip-Seq_HEK293_Human	2.13919751
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.13246348
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.10087018
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.08941511
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.02865667
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.99819917
19	MYC_18940864_ChIP-ChIP_HL60_Human	1.94534868
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.94067917
21	FUS_26573619_Chip-Seq_HEK293_Human	1.93242751
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.84868069
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.84538255
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.83805524
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.78617425
26	P300_19829295_ChIP-Seq_ESCs_Human	1.75951638
27	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.72871245
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.72284502
29	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.68046426
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.66223815
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.57443131
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.56388384
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.55178586
34	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.53646037
35	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.52524910
36	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.50195015
37	VDR_23849224_ChIP-Seq_CD4+_Human	1.49712212
38	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.46868851
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.46805825
40	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.46805825
41	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.46423604
42	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.44657635
43	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.39543157
44	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.39377049
45	NCOR_22424771_ChIP-Seq_293T_Human	1.36877980
46	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.36118850
47	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35355522
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35355522
49	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.34559483
50	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.31346445
51	REST_21632747_ChIP-Seq_MESCs_Mouse	1.30242850
52	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.29932839
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27076026
54	CBP_20019798_ChIP-Seq_JUKART_Human	1.27076026
55	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.25573952
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.23470093
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22730834
58	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20700447
59	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.20700447
60	AR_20517297_ChIP-Seq_VCAP_Human	1.20580254
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19426587
62	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18232415
63	TCF4_23295773_ChIP-Seq_U87_Human	1.17872683
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.17603034
65	AR_25329375_ChIP-Seq_VCAP_Human	1.17517713
66	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16141621
67	HOXB7_26014856_ChIP-Seq_BT474_Human	1.15067654
68	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.14234675
69	STAT3_23295773_ChIP-Seq_U87_Human	1.14046720
70	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.13800529
71	ELK1_19687146_ChIP-ChIP_HELA_Human	1.13509932
72	FOXP3_21729870_ChIP-Seq_TREG_Human	1.12205619
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10722054
74	HTT_18923047_ChIP-ChIP_STHdh_Human	1.09649919
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08946214
76	SMAD4_21799915_ChIP-Seq_A2780_Human	1.07584902
77	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06023644
78	TAF2_19829295_ChIP-Seq_ESCs_Human	1.05812265
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05282342
80	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.05069985
81	ERA_21632823_ChIP-Seq_H3396_Human	1.04990507
82	MYC_19829295_ChIP-Seq_ESCs_Human	1.03569986
83	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.02499273
84	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.02297608
85	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.02114964
86	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.01396814
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.00770208
88	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00608130
89	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.00447541
90	RUNX2_22187159_ChIP-Seq_PCA_Human	1.00424130
91	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.00324197
92	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99348344
93	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99239446
94	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98935989
95	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.97909001
96	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.97407769
97	NANOG_20526341_ChIP-Seq_ESCs_Human	0.97043757
98	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.96545963
99	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.96446914
100	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.96246129

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002876_abnormal_thyroid_physiology	2.70831189
2	MP0002102_abnormal_ear_morphology	2.70017329
3	MP0003195_calcinosis	2.62457729
4	MP0006072_abnormal_retinal_apoptosis	2.58312135
5	MP0005551_abnormal_eye_electrophysiolog	2.48941961
6	MP0006292_abnormal_olfactory_placode	2.42788080
7	MP0002837_dystrophic_cardiac_calcinosis	2.29769834
8	MP0004043_abnormal_pH_regulation	2.26953768
9	MP0003880_abnormal_central_pattern	2.23523091
10	MP0003646_muscle_fatigue	2.23363520
11	MP0004885_abnormal_endolymph	2.19679055
12	MP0002638_abnormal_pupillary_reflex	2.02724738
13	MP0001968_abnormal_touch/_nociception	2.00903753
14	MP0005253_abnormal_eye_physiology	1.97234891
15	MP0000427_abnormal_hair_cycle	1.96756395
16	MP0004133_heterotaxia	1.94557411
17	MP0009046_muscle_twitch	1.91898322
18	MP0005646_abnormal_pituitary_gland	1.88105308
19	MP0009745_abnormal_behavioral_response	1.83280573
20	MP0008875_abnormal_xenobiotic_pharmacok	1.82963356
21	MP0004142_abnormal_muscle_tone	1.79015870
22	MP0008877_abnormal_DNA_methylation	1.77002250
23	MP0002938_white_spotting	1.70072492
24	MP0008872_abnormal_physiological_respon	1.68757207
25	MP0005084_abnormal_gallbladder_morpholo	1.66807621
26	MP0000569_abnormal_digit_pigmentation	1.66248257
27	MP0001986_abnormal_taste_sensitivity	1.64295557
28	MP0002736_abnormal_nociception_after	1.63515257
29	MP0003136_yellow_coat_color	1.61056329
30	MP0000631_abnormal_neuroendocrine_gland	1.59803192
31	MP0002095_abnormal_skin_pigmentation	1.58469379
32	MP0002272_abnormal_nervous_system	1.55202769
33	MP0002653_abnormal_ependyma_morphology	1.54863718
34	MP0002163_abnormal_gland_morphology	1.54271531
35	MP0000015_abnormal_ear_pigmentation	1.53211769
36	MP0001485_abnormal_pinna_reflex	1.47999014
37	MP0005075_abnormal_melanosome_morpholog	1.47559251
38	MP0005645_abnormal_hypothalamus_physiol	1.47524648
39	MP0005379_endocrine/exocrine_gland_phen	1.45356370
40	MP0003011_delayed_dark_adaptation	1.41063708
41	MP0001529_abnormal_vocalization	1.40077032
42	MP0002160_abnormal_reproductive_system	1.38847027
43	MP0002234_abnormal_pharynx_morphology	1.37042848
44	MP0001501_abnormal_sleep_pattern	1.36864166
45	MP0001984_abnormal_olfaction	1.35868645
46	MP0000372_irregular_coat_pigmentation	1.34958181
47	MP0006276_abnormal_autonomic_nervous	1.32732704
48	MP0001905_abnormal_dopamine_level	1.32252715
49	MP0005174_abnormal_tail_pigmentation	1.29846396
50	MP0001502_abnormal_circadian_rhythm	1.29442431
51	MP0006036_abnormal_mitochondrial_physio	1.28633133
52	MP0005085_abnormal_gallbladder_physiolo	1.24895694
53	MP0005389_reproductive_system_phenotype	1.22952927
54	MP0002064_seizures	1.19284596
55	MP0003718_maternal_effect	1.18097208
56	MP0003283_abnormal_digestive_organ	1.12817727
57	MP0005195_abnormal_posterior_eye	1.11426502
58	MP0002557_abnormal_social/conspecific_i	1.10540221
59	MP0003787_abnormal_imprinting	1.09676206
60	MP0004147_increased_porphyrin_level	1.09407442
61	MP0010386_abnormal_urinary_bladder	1.08920363
62	MP0000383_abnormal_hair_follicle	1.07721357
63	MP0003937_abnormal_limbs/digits/tail_de	1.05118294
64	MP0001486_abnormal_startle_reflex	1.05029645
65	MP0002572_abnormal_emotion/affect_behav	1.04342786
66	MP0002928_abnormal_bile_duct	1.03455736
67	MP0004742_abnormal_vestibular_system	1.01870123
68	MP0003567_abnormal_fetal_cardiomyocyte	1.01840368
69	MP0004019_abnormal_vitamin_homeostasis	1.01213282
70	MP0002909_abnormal_adrenal_gland	1.00946084
71	MP0002277_abnormal_respiratory_mucosa	1.00825783
72	MP0005167_abnormal_blood-brain_barrier	1.00179079
73	MP0009697_abnormal_copulation	0.97279644
74	MP0002229_neurodegeneration	0.96152578
75	MP0002733_abnormal_thermal_nociception	0.95429953
76	MP0008775_abnormal_heart_ventricle	0.94632829
77	MP0004215_abnormal_myocardial_fiber	0.94304779
78	MP0004924_abnormal_behavior	0.93459978
79	MP0005386_behavior/neurological_phenoty	0.93459978
80	MP0002735_abnormal_chemical_nociception	0.91705903
81	MP0006035_abnormal_mitochondrial_morpho	0.91687777
82	MP0008058_abnormal_DNA_repair	0.91564901
83	MP0001324_abnormal_eye_pigmentation	0.90432923
84	MP0002693_abnormal_pancreas_physiology	0.90168329
85	MP0003122_maternal_imprinting	0.88905825
86	MP0001970_abnormal_pain_threshold	0.88708764
87	MP0003878_abnormal_ear_physiology	0.88677882
88	MP0005377_hearing/vestibular/ear_phenot	0.88677882
89	MP0005410_abnormal_fertilization	0.88429180
90	MP0005332_abnormal_amino_acid	0.87044972
91	MP0002067_abnormal_sensory_capabilities	0.86856517
92	MP0001764_abnormal_homeostasis	0.86644140
93	MP0001963_abnormal_hearing_physiology	0.84694093
94	MP0001293_anophthalmia	0.84668261
95	MP0003786_premature_aging	0.83050024
96	MP0005365_abnormal_bile_salt	0.82507248
97	MP0002063_abnormal_learning/memory/cond	0.82396236
98	MP0002752_abnormal_somatic_nervous	0.81540759
99	MP0004484_altered_response_of	0.80179590
100	MP0000371_diluted_coat_color	0.79824606

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.50993941
2	Abnormality of midbrain morphology (HP:0002418)	4.40689209
3	Molar tooth sign on MRI (HP:0002419)	4.40689209
4	Congenital stationary night blindness (HP:0007642)	3.99444867
5	Pancreatic fibrosis (HP:0100732)	3.80664964
6	Nephronophthisis (HP:0000090)	3.64390777
7	Abnormality of the renal cortex (HP:0011035)	3.62949729
8	True hermaphroditism (HP:0010459)	3.61353011
9	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.58028498
10	Abnormality of alanine metabolism (HP:0010916)	3.58028498
11	Hyperalaninemia (HP:0003348)	3.58028498
12	Type II lissencephaly (HP:0007260)	3.47674434
13	Pendular nystagmus (HP:0012043)	3.45923793
14	Abolished electroretinogram (ERG) (HP:0000550)	3.32719593
15	Abnormality of the renal medulla (HP:0100957)	3.27537799
16	Chronic hepatic failure (HP:0100626)	2.91785417
17	Tubular atrophy (HP:0000092)	2.90992155
18	Polydipsia (HP:0001959)	2.89653930
19	Abnormal drinking behavior (HP:0030082)	2.89653930
20	Acute necrotizing encephalopathy (HP:0006965)	2.88906607
21	3-Methylglutaconic aciduria (HP:0003535)	2.84600464
22	Bile duct proliferation (HP:0001408)	2.83912821
23	Abnormal biliary tract physiology (HP:0012439)	2.83912821
24	Chorioretinal atrophy (HP:0000533)	2.76311304
25	Mitochondrial inheritance (HP:0001427)	2.65765572
26	Cystic liver disease (HP:0006706)	2.64876624
27	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.64155079
28	Increased CSF lactate (HP:0002490)	2.61443598
29	Acute encephalopathy (HP:0006846)	2.59312630
30	Hepatocellular necrosis (HP:0001404)	2.57125276
31	Short tibia (HP:0005736)	2.53195717
32	Abnormal mitochondria in muscle tissue (HP:0008316)	2.51575499
33	Medial flaring of the eyebrow (HP:0010747)	2.49640214
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.49608973
35	Progressive macrocephaly (HP:0004481)	2.48358240
36	Colon cancer (HP:0003003)	2.45967642
37	Hepatic necrosis (HP:0002605)	2.41924027
38	Renal cortical cysts (HP:0000803)	2.41109403
39	Absent/shortened dynein arms (HP:0200106)	2.39521113
40	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.39521113
41	Keratoconus (HP:0000563)	2.36617920
42	Increased corneal curvature (HP:0100692)	2.36617920
43	Fibular aplasia (HP:0002990)	2.34986813
44	Attenuation of retinal blood vessels (HP:0007843)	2.33156400
45	Polyuria (HP:0000103)	2.28646508
46	Cerebellar dysplasia (HP:0007033)	2.20849963
47	Lissencephaly (HP:0001339)	2.11849127
48	Furrowed tongue (HP:0000221)	2.09267319
49	Inability to walk (HP:0002540)	2.08846227
50	Hyperglycinuria (HP:0003108)	2.06853978
51	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.03392552
52	Retinal dysplasia (HP:0007973)	2.03378246
53	Anencephaly (HP:0002323)	2.03312358
54	Aplasia/hypoplasia of the uterus (HP:0008684)	2.02564677
55	Sclerocornea (HP:0000647)	2.01793892
56	Congenital, generalized hypertrichosis (HP:0004540)	2.00800216
57	Large for gestational age (HP:0001520)	2.00329958
58	Increased serum lactate (HP:0002151)	1.96707793
59	Fibular hypoplasia (HP:0003038)	1.96173201
60	Optic disc pallor (HP:0000543)	1.95395776
61	Hypoplasia of the pons (HP:0012110)	1.95266016
62	Decreased circulating renin level (HP:0003351)	1.95160694
63	Abnormality of the pons (HP:0007361)	1.93807245
64	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.93557879
65	Hypoplasia of the fovea (HP:0007750)	1.93557879
66	Male pseudohermaphroditism (HP:0000037)	1.93492632
67	Abnormal respiratory motile cilium morphology (HP:0005938)	1.92638004
68	Abnormal respiratory epithelium morphology (HP:0012253)	1.92638004
69	Lipid accumulation in hepatocytes (HP:0006561)	1.89255210
70	Ketoacidosis (HP:0001993)	1.87044801
71	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.84213720
72	Hypothermia (HP:0002045)	1.83211773
73	Progressive inability to walk (HP:0002505)	1.82864818
74	Tubulointerstitial fibrosis (HP:0005576)	1.82039859
75	Synostosis involving the elbow (HP:0003938)	1.81958351
76	Humeroradial synostosis (HP:0003041)	1.81958351
77	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.80794970
78	Increased hepatocellular lipid droplets (HP:0006565)	1.80601747
79	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.79400558
80	Ketosis (HP:0001946)	1.78826981
81	Abnormal urine output (HP:0012590)	1.76812229
82	Hyperventilation (HP:0002883)	1.76756071
83	Congenital hepatic fibrosis (HP:0002612)	1.76746553
84	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.76697608
85	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.75629228
86	Gait imbalance (HP:0002141)	1.75111042
87	Abnormality of renal excretion (HP:0011036)	1.73493718
88	Congenital primary aphakia (HP:0007707)	1.73364110
89	Occipital encephalocele (HP:0002085)	1.72958742
90	Decreased central vision (HP:0007663)	1.72352867
91	Abnormality of glycine metabolism (HP:0010895)	1.71720184
92	Abnormality of serine family amino acid metabolism (HP:0010894)	1.71720184
93	Nephrogenic diabetes insipidus (HP:0009806)	1.70039894
94	Aplasia/Hypoplasia of the patella (HP:0006498)	1.69744869
95	Abnormal number of erythroid precursors (HP:0012131)	1.69550221
96	Optic nerve hypoplasia (HP:0000609)	1.68958149
97	Abnormal ciliary motility (HP:0012262)	1.66013446
98	Lactic acidosis (HP:0003128)	1.65225028
99	Postaxial hand polydactyly (HP:0001162)	1.64277396
100	Glycosuria (HP:0003076)	1.64000246

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.40440762
2	ADRBK2	3.68465118
3	BMPR1B	3.54644619
4	WNK4	3.46743233
5	ZAK	3.35056546
6	GRK1	2.76967077
7	TAOK3	2.68738602
8	INSRR	2.64292478
9	WNK3	2.56646523
10	TLK1	2.42161373
11	NUAK1	2.39207998
12	PINK1	2.25455764
13	MAP4K2	1.86863286
14	MAP3K4	1.82877826
15	STK39	1.82419539
16	ACVR1B	1.65378955
17	STK16	1.59785627
18	BCKDK	1.49385757
19	DAPK2	1.48815765
20	OXSR1	1.43022910
21	TXK	1.42690251
22	MAP2K6	1.37828428
23	TRIM28	1.36628555
24	CSNK1G1	1.22321875
25	MAPK13	1.18935546
26	DYRK2	1.14745489
27	CSNK1G3	1.13309777
28	CSNK1G2	1.12945992
29	PHKG2	1.10248805
30	PHKG1	1.10248805
31	ADRBK1	1.09080658
32	VRK2	1.09051632
33	MAPK15	1.06724420
34	TGFBR1	1.05847493
35	EPHA4	1.05700064
36	MAP2K7	1.04249994
37	STK3	1.00331328
38	CSNK1A1L	0.91487695
39	PAK3	0.91451956
40	TNIK	0.89997365
41	PTK2B	0.87664394
42	CAMKK2	0.86231819
43	FGFR2	0.84863104
44	PRKCE	0.84495019
45	MUSK	0.80963753
46	BCR	0.79811658
47	STK38L	0.74997330
48	CASK	0.74792211
49	EIF2AK3	0.74277025
50	TAF1	0.74251808
51	PRKCG	0.74032636
52	TSSK6	0.72878080
53	PLK2	0.72272710
54	WEE1	0.69786027
55	VRK1	0.68208864
56	PRKCI	0.67454850
57	NTRK3	0.65300462
58	NME1	0.63419583
59	IRAK1	0.61342461
60	MAPKAPK3	0.60042175
61	PNCK	0.59171138
62	MARK1	0.58791678
63	TIE1	0.55096459
64	PIM2	0.54115338
65	RPS6KA5	0.54047191
66	GRK7	0.54012959
67	BRSK2	0.53931950
68	MKNK2	0.52715654
69	IKBKB	0.52518375
70	PLK3	0.52080901
71	ITK	0.51954689
72	NLK	0.51681653
73	WNK1	0.51413240
74	CAMK2A	0.48915814
75	PRKCQ	0.48393812
76	CAMK1D	0.47542937
77	STK11	0.46003854
78	LATS1	0.45694689
79	PIM1	0.45414702
80	CAMK1	0.43883603
81	PLK4	0.42832217
82	CSNK1D	0.42748810
83	CSNK1A1	0.42672759
84	MAP2K4	0.41935187
85	PRKAA2	0.40649137
86	PRKACA	0.40578008
87	CHEK2	0.39389567
88	NTRK2	0.39093962
89	PDK2	0.38954312
90	MST4	0.37050670
91	ATR	0.36575597
92	KIT	0.35641588
93	CDK3	0.35582794
94	TEC	0.33629364
95	TNK2	0.33128259
96	MAP3K9	0.31537431
97	PRKAA1	0.30357485
98	OBSCN	0.29895082
99	CSNK1E	0.29520170
100	BUB1	0.29350183

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.35575421
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.09740529
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.72431136
4	Protein export_Homo sapiens_hsa03060	2.49973514
5	Parkinsons disease_Homo sapiens_hsa05012	2.43714650
6	Phototransduction_Homo sapiens_hsa04744	2.37821960
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.30475521
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.28266381
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.16083522
10	RNA polymerase_Homo sapiens_hsa03020	2.15746065
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.06568940
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.98777522
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.93161288
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.86393533
15	Butanoate metabolism_Homo sapiens_hsa00650	1.82117908
16	Ribosome_Homo sapiens_hsa03010	1.80682623
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.80523519
18	Huntingtons disease_Homo sapiens_hsa05016	1.78184380
19	Basal transcription factors_Homo sapiens_hsa03022	1.73545249
20	One carbon pool by folate_Homo sapiens_hsa00670	1.72624514
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.69366788
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.61557534
23	Caffeine metabolism_Homo sapiens_hsa00232	1.61470273
24	Alzheimers disease_Homo sapiens_hsa05010	1.59408443
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.57892654
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.56185188
27	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.53192360
28	Ether lipid metabolism_Homo sapiens_hsa00565	1.48132507
29	Homologous recombination_Homo sapiens_hsa03440	1.42390333
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.38068421
31	Sulfur metabolism_Homo sapiens_hsa00920	1.36092687
32	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.34860865
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.28490586
34	Cardiac muscle contraction_Homo sapiens_hsa04260	1.22798150
35	RNA degradation_Homo sapiens_hsa03018	1.22674121
36	Proteasome_Homo sapiens_hsa03050	1.22302618
37	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.17791667
38	Nicotine addiction_Homo sapiens_hsa05033	1.17063469
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.15290342
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.14493552
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.13915784
42	Regulation of autophagy_Homo sapiens_hsa04140	1.11292608
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.03546558
44	Taste transduction_Homo sapiens_hsa04742	1.00316962
45	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.99058071
46	Chemical carcinogenesis_Homo sapiens_hsa05204	0.98287741
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97260046
48	Propanoate metabolism_Homo sapiens_hsa00640	0.96339006
49	Sulfur relay system_Homo sapiens_hsa04122	0.93545457
50	Purine metabolism_Homo sapiens_hsa00230	0.93467617
51	Peroxisome_Homo sapiens_hsa04146	0.91776472
52	Morphine addiction_Homo sapiens_hsa05032	0.91698309
53	Primary immunodeficiency_Homo sapiens_hsa05340	0.90932286
54	Olfactory transduction_Homo sapiens_hsa04740	0.89937061
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.89393350
56	Insulin secretion_Homo sapiens_hsa04911	0.88099225
57	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.86337127
58	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.86093120
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.83759730
60	Metabolic pathways_Homo sapiens_hsa01100	0.82056778
61	beta-Alanine metabolism_Homo sapiens_hsa00410	0.81289482
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.77560929
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77454295
64	Retinol metabolism_Homo sapiens_hsa00830	0.75500085
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.74569515
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.72175003
67	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.71280727
68	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.70253392
69	ABC transporters_Homo sapiens_hsa02010	0.68681362
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.65733620
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.64875621
72	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.64345963
73	Serotonergic synapse_Homo sapiens_hsa04726	0.63163704
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62745784
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.60761364
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60563548
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.56928231
78	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.55477852
79	Mineral absorption_Homo sapiens_hsa04978	0.55347220
80	Circadian entrainment_Homo sapiens_hsa04713	0.54968406
81	Histidine metabolism_Homo sapiens_hsa00340	0.52719722
82	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.52581992
83	GABAergic synapse_Homo sapiens_hsa04727	0.50856689
84	Fatty acid elongation_Homo sapiens_hsa00062	0.49174134
85	Glutamatergic synapse_Homo sapiens_hsa04724	0.46897483
86	Arginine and proline metabolism_Homo sapiens_hsa00330	0.43279869
87	Calcium signaling pathway_Homo sapiens_hsa04020	0.42261725
88	Nucleotide excision repair_Homo sapiens_hsa03420	0.41956454
89	RNA transport_Homo sapiens_hsa03013	0.41265433
90	Folate biosynthesis_Homo sapiens_hsa00790	0.40284717
91	Non-homologous end-joining_Homo sapiens_hsa03450	0.38729396
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.36757043
93	Steroid biosynthesis_Homo sapiens_hsa00100	0.36516891
94	Fatty acid degradation_Homo sapiens_hsa00071	0.36194684
95	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33305779
96	Salivary secretion_Homo sapiens_hsa04970	0.33109368
97	Asthma_Homo sapiens_hsa05310	0.32005497
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.31660817
99	p53 signaling pathway_Homo sapiens_hsa04115	0.29609255
100	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.29153487

ARHGAP42P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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