ARHGAP44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular potassium ion homeostasis (GO:0030007)5.59926047
2synaptic vesicle exocytosis (GO:0016079)5.52439339
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.25756684
4vocalization behavior (GO:0071625)5.23220707
5glutamate secretion (GO:0014047)5.19984671
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.17873514
7regulation of synaptic vesicle exocytosis (GO:2000300)5.03631216
8sodium ion export (GO:0071436)4.79377024
9synaptic vesicle maturation (GO:0016188)4.76207607
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.70369300
11neuronal action potential propagation (GO:0019227)4.68163653
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.60652725
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.47592156
14regulation of glutamate receptor signaling pathway (GO:1900449)4.43077288
15regulation of synaptic vesicle transport (GO:1902803)4.42520395
16neuron cell-cell adhesion (GO:0007158)4.38139975
17neurotransmitter secretion (GO:0007269)4.32759840
18locomotory exploration behavior (GO:0035641)4.29900032
19protein localization to synapse (GO:0035418)4.28500622
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.27970980
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.27725990
22neurotransmitter-gated ion channel clustering (GO:0072578)4.11603918
23negative regulation of dendrite morphogenesis (GO:0050774)4.06486308
24potassium ion import (GO:0010107)3.94324256
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.92296558
26neuron-neuron synaptic transmission (GO:0007270)3.89069343
27synaptic transmission, glutamatergic (GO:0035249)3.85423916
28dendritic spine morphogenesis (GO:0060997)3.79415946
29regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.78014186
30negative regulation of synaptic transmission, GABAergic (GO:0032229)3.77546557
31postsynaptic membrane organization (GO:0001941)3.71330504
32presynaptic membrane assembly (GO:0097105)3.70962136
33potassium ion homeostasis (GO:0055075)3.69364206
34glutamate receptor signaling pathway (GO:0007215)3.62736563
35regulation of synapse maturation (GO:0090128)3.61130929
36regulation of neuronal synaptic plasticity (GO:0048168)3.60781112
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.54389058
38cellular sodium ion homeostasis (GO:0006883)3.54367367
39exploration behavior (GO:0035640)3.53625260
40neurotransmitter transport (GO:0006836)3.47428684
41long-term synaptic potentiation (GO:0060291)3.46847632
42presynaptic membrane organization (GO:0097090)3.45608087
43proline transport (GO:0015824)3.43005845
44cerebellar Purkinje cell differentiation (GO:0021702)3.40132493
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.38228598
46synaptic vesicle endocytosis (GO:0048488)3.37489661
47ATP hydrolysis coupled proton transport (GO:0015991)3.36510973
48energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.36510973
49regulation of synapse structural plasticity (GO:0051823)3.33143552
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.33028186
51gamma-aminobutyric acid transport (GO:0015812)3.31121397
52regulation of neurotransmitter secretion (GO:0046928)3.29823830
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26636334
54neuromuscular process controlling balance (GO:0050885)3.26492816
55transferrin transport (GO:0033572)3.25967642
56membrane depolarization during action potential (GO:0086010)3.25055264
57regulation of postsynaptic membrane potential (GO:0060078)3.24512417
58neuromuscular synaptic transmission (GO:0007274)3.24349838
59positive regulation of membrane potential (GO:0045838)3.22696212
60regulation of synaptic plasticity (GO:0048167)3.17979677
61positive regulation of synapse maturation (GO:0090129)3.17436386
62regulation of neurotransmitter levels (GO:0001505)3.16765919
63cerebellar granule cell differentiation (GO:0021707)3.14370332
64negative regulation of dendrite development (GO:2000171)3.13616489
65neuronal ion channel clustering (GO:0045161)3.13567195
66positive regulation of dendritic spine development (GO:0060999)3.13154573
67positive regulation of neurotransmitter transport (GO:0051590)3.13129762
68cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.13128982
69serotonin metabolic process (GO:0042428)3.12947958
70activation of protein kinase A activity (GO:0034199)3.12939419
71neuromuscular process controlling posture (GO:0050884)3.11419611
72layer formation in cerebral cortex (GO:0021819)3.09912128
73regulation of neurotransmitter transport (GO:0051588)3.09262556
74positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.08632079
75L-amino acid import (GO:0043092)3.08606113
76innervation (GO:0060384)3.05743235
77regulation of synaptic transmission, glutamatergic (GO:0051966)3.05645985
78neuron recognition (GO:0008038)3.05126251
79central nervous system myelination (GO:0022010)3.04598416
80axon ensheathment in central nervous system (GO:0032291)3.04598416
81ferric iron transport (GO:0015682)3.03951574
82trivalent inorganic cation transport (GO:0072512)3.03951574
83regulation of vesicle fusion (GO:0031338)3.00290313
84G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.97977926
85membrane depolarization (GO:0051899)2.97695537
86regulation of calcium ion-dependent exocytosis (GO:0017158)2.97132537
87cell migration in hindbrain (GO:0021535)2.96056116
88inositol phosphate catabolic process (GO:0071545)2.95627495
89startle response (GO:0001964)2.95058044
90synaptic transmission (GO:0007268)2.94259399
91behavioral response to nicotine (GO:0035095)2.94211099
92long-term memory (GO:0007616)2.93842422
93positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.93715442
94multicellular organismal signaling (GO:0035637)2.93490904
95detection of calcium ion (GO:0005513)2.92032227
96negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91938793
97striatum development (GO:0021756)2.91426272
98transmission of nerve impulse (GO:0019226)2.90961161
99response to histamine (GO:0034776)2.89082049
100calcium ion-dependent exocytosis (GO:0017156)2.88482891
101cell communication involved in cardiac conduction (GO:0086065)2.87399900
102primary amino compound metabolic process (GO:1901160)2.87275408
103positive regulation of synaptic transmission, GABAergic (GO:0032230)2.86338809
104response to auditory stimulus (GO:0010996)2.85632529
105synapse assembly (GO:0007416)2.84912654
106positive regulation of neurotransmitter secretion (GO:0001956)2.84747704
107establishment of synaptic vesicle localization (GO:0097480)2.84128697
108synaptic vesicle transport (GO:0048489)2.84128697
109regulation of voltage-gated calcium channel activity (GO:1901385)2.83641207
110female mating behavior (GO:0060180)2.83638834
111mechanosensory behavior (GO:0007638)2.83012913
112positive regulation of synaptic transmission (GO:0050806)2.81815247
113cell communication by electrical coupling (GO:0010644)2.81536869
114neuromuscular process (GO:0050905)2.81447810
115dendritic spine organization (GO:0097061)2.81301484
116regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.79727529
117regulation of glutamate secretion (GO:0014048)2.78383876
118regulation of female receptivity (GO:0045924)2.78189703
119positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.78045439
120positive regulation of potassium ion transmembrane transport (GO:1901381)2.77919677
121cardiac conduction (GO:0061337)2.76991943
122positive regulation of synapse assembly (GO:0051965)2.76210686
123regulation of synaptic transmission (GO:0050804)2.75962944
124regulation of dendritic spine morphogenesis (GO:0061001)2.75728053
125behavioral response to cocaine (GO:0048148)2.74590859
126cell differentiation in hindbrain (GO:0021533)2.74207973
127membrane hyperpolarization (GO:0060081)2.73803908
128auditory behavior (GO:0031223)2.73386949
129learning (GO:0007612)2.73212168
130negative regulation of hormone biosynthetic process (GO:0032353)2.72013154
131response to dietary excess (GO:0002021)2.72006200

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.28282817
2GBX2_23144817_ChIP-Seq_PC3_Human4.19882960
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.04073490
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92103237
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78598469
6REST_21632747_ChIP-Seq_MESCs_Mouse2.58187604
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50054495
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50054495
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47020167
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41460623
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35697134
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.34297045
13TAF15_26573619_Chip-Seq_HEK293_Human2.33344504
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32187597
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30515026
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26882917
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.18784371
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.16581509
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.13795209
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13613798
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11356921
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03881034
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03647917
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02977868
25DROSHA_22980978_ChIP-Seq_HELA_Human1.98719587
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.98562237
27SMAD4_21799915_ChIP-Seq_A2780_Human1.96342235
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.93556531
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93118326
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85432658
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85120457
32P300_19829295_ChIP-Seq_ESCs_Human1.71599007
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68400917
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68000358
35AR_21572438_ChIP-Seq_LNCaP_Human1.64806873
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60572229
37ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.55426825
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55419528
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55042606
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52566019
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51130934
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48983580
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43913191
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.43233702
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.41505185
46AR_25329375_ChIP-Seq_VCAP_Human1.39585894
47SOX2_21211035_ChIP-Seq_LN229_Gbm1.39548366
48RNF2_27304074_Chip-Seq_NSC_Mouse1.37996206
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37640432
50STAT3_23295773_ChIP-Seq_U87_Human1.37577760
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36092211
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35917570
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.34357942
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32535325
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30665960
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29322856
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.26139208
58RING1B_27294783_Chip-Seq_NPCs_Mouse1.25597381
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.24657717
60VDR_22108803_ChIP-Seq_LS180_Human1.24442803
61TCF4_23295773_ChIP-Seq_U87_Human1.23860034
62FUS_26573619_Chip-Seq_HEK293_Human1.22921253
63AHR_22903824_ChIP-Seq_MCF-7_Human1.22747774
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.20454960
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20142113
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20086103
67CTCF_27219007_Chip-Seq_Bcells_Human1.19691700
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18893332
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17548405
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17115542
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16956509
72RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16380553
73AR_19668381_ChIP-Seq_PC3_Human1.15177308
74TP53_20018659_ChIP-ChIP_R1E_Mouse1.14466054
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14260125
76GATA1_26923725_Chip-Seq_HPCs_Mouse1.13772776
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11211080
78ZNF274_21170338_ChIP-Seq_K562_Hela1.11189966
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10843551
80RUNX2_22187159_ChIP-Seq_PCA_Human1.10824762
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10669411
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08941134
83KDM2B_26808549_Chip-Seq_K562_Human1.06240756
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.06100503
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05633211
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05477283
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05438118
88OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04826343
89JUN_21703547_ChIP-Seq_K562_Human1.04793441
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04593673
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04263109
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.04050036
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03866322
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.03218352
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02944332
96IGF1R_20145208_ChIP-Seq_DFB_Human1.01951290
97ER_23166858_ChIP-Seq_MCF-7_Human1.01170092
98TET1_21490601_ChIP-Seq_MESCs_Mouse1.00932815
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00179998
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99323655
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99323655
102NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98505763
103ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97933358
104WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97558289
105BCAT_22108803_ChIP-Seq_LS180_Human0.97427872
106NANOG_18555785_Chip-Seq_ESCs_Mouse0.97415111
107CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96381650
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95390280
109SMAD3_21741376_ChIP-Seq_ESCs_Human0.94956240
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94692436
111EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94040475
112SOX9_26525672_Chip-Seq_HEART_Mouse0.91896281
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91610827
114SMAD4_21741376_ChIP-Seq_HESCs_Human0.91104121
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91038383
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90865603
117TP53_18474530_ChIP-ChIP_U2OS_Human0.90528425
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90508992
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85142503
120ESR2_21235772_ChIP-Seq_MCF-7_Human0.83532405
121SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.80518321
122OCT4_19829295_ChIP-Seq_ESCs_Human0.77648459
123WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.76424286
124SMAD3_21741376_ChIP-Seq_HESCs_Human0.76361644
125CTNNB1_20460455_ChIP-Seq_HCT116_Human0.74240305
126KLF4_19829295_ChIP-Seq_ESCs_Human0.74236048
127THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.73356884

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.16050005
2MP0003880_abnormal_central_pattern4.71083739
3MP0003635_abnormal_synaptic_transmissio3.76812352
4MP0004270_analgesia3.62276035
5MP0009046_muscle_twitch3.41564957
6MP0001968_abnormal_touch/_nociception3.22386656
7MP0009745_abnormal_behavioral_response3.17314915
8MP0002064_seizures3.04391643
9MP0002063_abnormal_learning/memory/cond3.04230452
10MP0002736_abnormal_nociception_after2.85704968
11MP0002734_abnormal_mechanical_nocicepti2.78340400
12MP0002735_abnormal_chemical_nociception2.70590792
13MP0002572_abnormal_emotion/affect_behav2.67815142
14MP0002272_abnormal_nervous_system2.65165502
15MP0001486_abnormal_startle_reflex2.23481028
16MP0001501_abnormal_sleep_pattern2.14173058
17MP0009780_abnormal_chondrocyte_physiolo2.13586532
18MP0003787_abnormal_imprinting2.10586140
19MP0003122_maternal_imprinting2.07415160
20MP0002067_abnormal_sensory_capabilities2.06407688
21MP0002733_abnormal_thermal_nociception2.01480367
22MP0001440_abnormal_grooming_behavior2.01324408
23MP0001970_abnormal_pain_threshold1.93475137
24MP0005646_abnormal_pituitary_gland1.92217971
25MP0006276_abnormal_autonomic_nervous1.89949814
26MP0003879_abnormal_hair_cell1.88708461
27MP0005423_abnormal_somatic_nervous1.88477610
28MP0008569_lethality_at_weaning1.81894456
29MP0001984_abnormal_olfaction1.81600095
30MP0002837_dystrophic_cardiac_calcinosis1.79355817
31MP0002184_abnormal_innervation1.77679749
32MP0004858_abnormal_nervous_system1.70708293
33MP0002822_catalepsy1.63705891
34MP0002557_abnormal_social/conspecific_i1.62313490
35MP0004924_abnormal_behavior1.59463557
36MP0005386_behavior/neurological_phenoty1.59463557
37MP0004811_abnormal_neuron_physiology1.53392219
38MP0000778_abnormal_nervous_system1.50714049
39MP0004142_abnormal_muscle_tone1.50354278
40MP0002909_abnormal_adrenal_gland1.49375271
41MP0001529_abnormal_vocalization1.46309122
42MP0005645_abnormal_hypothalamus_physiol1.45608000
43MP0002876_abnormal_thyroid_physiology1.45160472
44MP0000751_myopathy1.43870564
45MP0000955_abnormal_spinal_cord1.39489333
46MP0002066_abnormal_motor_capabilities/c1.32740734
47MP0002882_abnormal_neuron_morphology1.29597901
48MP0001188_hyperpigmentation1.26998424
49MP0003329_amyloid_beta_deposits1.26813407
50MP0001905_abnormal_dopamine_level1.25103009
51MP0004215_abnormal_myocardial_fiber1.21127639
52MP0004085_abnormal_heartbeat1.19979466
53MP0003646_muscle_fatigue1.18009321
54MP0004145_abnormal_muscle_electrophysio1.15731697
55MP0001986_abnormal_taste_sensitivity1.15551121
56MP0003283_abnormal_digestive_organ1.13357136
57MP0003136_yellow_coat_color1.12730038
58MP0001502_abnormal_circadian_rhythm1.06169090
59MP0004484_altered_response_of1.00984238
60MP0003633_abnormal_nervous_system1.00380668
61MP0000013_abnormal_adipose_tissue0.97904972
62MP0002638_abnormal_pupillary_reflex0.97388855
63MP0004036_abnormal_muscle_relaxation0.95225254
64MP0001177_atelectasis0.94091182
65MP0004130_abnormal_muscle_cell0.93877017
66MP0000566_synostosis0.93776703
67MP0005499_abnormal_olfactory_system0.93502997
68MP0005394_taste/olfaction_phenotype0.93502997
69MP0008877_abnormal_DNA_methylation0.92523520
70MP0004133_heterotaxia0.92093939
71MP0003183_abnormal_peptide_metabolism0.92075991
72MP0008872_abnormal_physiological_respon0.92068033
73MP0002152_abnormal_brain_morphology0.91658809
74MP0002229_neurodegeneration0.91541146
75MP0000749_muscle_degeneration0.90961215
76MP0004084_abnormal_cardiac_muscle0.90234343
77MP0001963_abnormal_hearing_physiology0.90038933
78MP0003631_nervous_system_phenotype0.89838448
79MP0010386_abnormal_urinary_bladder0.87515342
80MP0003121_genomic_imprinting0.85565820
81MP0004885_abnormal_endolymph0.84339396
82MP0002069_abnormal_eating/drinking_beha0.83789779
83MP0003137_abnormal_impulse_conducting0.81472182
84MP0005377_hearing/vestibular/ear_phenot0.78924100
85MP0003878_abnormal_ear_physiology0.78924100
86MP0003123_paternal_imprinting0.78517022
87MP0002972_abnormal_cardiac_muscle0.76736035
88MP0004233_abnormal_muscle_weight0.75998316
89MP0004043_abnormal_pH_regulation0.75867840
90MP0002752_abnormal_somatic_nervous0.74670808
91MP0005551_abnormal_eye_electrophysiolog0.73983760
92MP0005620_abnormal_muscle_contractility0.72685136
93MP0003938_abnormal_ear_development0.71949389
94MP0000631_abnormal_neuroendocrine_gland0.71193352
95MP0001664_abnormal_digestion0.71187612
96MP0000678_abnormal_parathyroid_gland0.70644514
97MP0008874_decreased_physiological_sensi0.70494549
98MP0003861_abnormal_nervous_system0.69019698
99MP0002160_abnormal_reproductive_system0.67436924
100MP0001485_abnormal_pinna_reflex0.67340482
101MP0005535_abnormal_body_temperature0.67194458
102MP0003119_abnormal_digestive_system0.66613844
103MP0002653_abnormal_ependyma_morphology0.66322984
104MP0003690_abnormal_glial_cell0.65489828
105MP0002249_abnormal_larynx_morphology0.65336915
106MP0005171_absent_coat_pigmentation0.63728341
107MP0000920_abnormal_myelination0.63490039
108MP0001765_abnormal_ion_homeostasis0.63298654
109MP0010769_abnormal_survival0.63294727
110MP0001943_abnormal_respiration0.63115925
111MP0004742_abnormal_vestibular_system0.63030424
112MP0008004_abnormal_stomach_pH0.62768626
113MP0002751_abnormal_autonomic_nervous0.62055479
114MP0005623_abnormal_meninges_morphology0.61929654
115MP0006292_abnormal_olfactory_placode0.61471341
116MP0002082_postnatal_lethality0.61195863
117MP0010770_preweaning_lethality0.61195863
118MP0003632_abnormal_nervous_system0.61072529
119MP0006138_congestive_heart_failure0.60631748
120MP0003634_abnormal_glial_cell0.59954200
121MP0001299_abnormal_eye_distance/0.56937226
122MP0000026_abnormal_inner_ear0.56202346

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.69293863
2Myokymia (HP:0002411)5.71127972
3Atonic seizures (HP:0010819)5.57312773
4Febrile seizures (HP:0002373)5.12970307
5Focal seizures (HP:0007359)5.11025899
6Epileptic encephalopathy (HP:0200134)5.09014062
7Visual hallucinations (HP:0002367)4.49683833
8Progressive cerebellar ataxia (HP:0002073)4.35844751
9Absence seizures (HP:0002121)4.15994532
10Pheochromocytoma (HP:0002666)3.75612934
11Dialeptic seizures (HP:0011146)3.71941768
12Hyperventilation (HP:0002883)3.70356046
13Generalized tonic-clonic seizures (HP:0002069)3.62356757
14Hemiplegia (HP:0002301)3.61339148
15Neuroendocrine neoplasm (HP:0100634)3.36959891
16Gaze-evoked nystagmus (HP:0000640)3.25519081
17Action tremor (HP:0002345)3.14003042
18Broad-based gait (HP:0002136)3.06511071
19Impaired vibration sensation in the lower limbs (HP:0002166)2.98031973
20Abnormal hair whorl (HP:0010721)2.97962646
21Hemiparesis (HP:0001269)2.96176048
22Dysdiadochokinesis (HP:0002075)2.81663287
23Abnormal eating behavior (HP:0100738)2.78824308
24Akinesia (HP:0002304)2.74418010
25Anxiety (HP:0000739)2.70223023
26Truncal ataxia (HP:0002078)2.70005671
27Failure to thrive in infancy (HP:0001531)2.66913292
28Amblyopia (HP:0000646)2.64129311
29Gait imbalance (HP:0002141)2.62001259
30Genetic anticipation (HP:0003743)2.58989933
31Poor eye contact (HP:0000817)2.57552410
32Neurofibrillary tangles (HP:0002185)2.57241540
33Scanning speech (HP:0002168)2.56482530
34Depression (HP:0000716)2.56432392
35Dysmetric saccades (HP:0000641)2.51778984
36Ankle clonus (HP:0011448)2.51480721
37Epileptiform EEG discharges (HP:0011182)2.50791132
38Fetal akinesia sequence (HP:0001989)2.49141558
39Acute necrotizing encephalopathy (HP:0006965)2.45784477
40Annular pancreas (HP:0001734)2.43845670
41Abnormal mitochondria in muscle tissue (HP:0008316)2.43297983
42Urinary bladder sphincter dysfunction (HP:0002839)2.40822099
43Congenital primary aphakia (HP:0007707)2.38893837
44Abnormal social behavior (HP:0012433)2.36040384
45Impaired social interactions (HP:0000735)2.36040384
46Dysmetria (HP:0001310)2.34780842
47Medial flaring of the eyebrow (HP:0010747)2.31001172
48Decreased circulating renin level (HP:0003351)2.29027254
49Polyphagia (HP:0002591)2.28231246
50Agitation (HP:0000713)2.28155918
51Intention tremor (HP:0002080)2.27864746
52EEG with generalized epileptiform discharges (HP:0011198)2.27645226
53Progressive macrocephaly (HP:0004481)2.25912166
54Poor suck (HP:0002033)2.25909806
55Obstructive sleep apnea (HP:0002870)2.25362845
56Nephrogenic diabetes insipidus (HP:0009806)2.25235108
57Ventricular fibrillation (HP:0001663)2.24302029
58Supranuclear gaze palsy (HP:0000605)2.24200152
59Impaired smooth pursuit (HP:0007772)2.23062853
60Limb dystonia (HP:0002451)2.22020610
61Abnormality of binocular vision (HP:0011514)2.20240813
62Diplopia (HP:0000651)2.20240813
63Impaired vibratory sensation (HP:0002495)2.16509040
64Resting tremor (HP:0002322)2.16090433
65Hypsarrhythmia (HP:0002521)2.15391245
66Mutism (HP:0002300)2.15311977
67Type II lissencephaly (HP:0007260)2.15086272
68Abnormality of the lower motor neuron (HP:0002366)2.13508012
69Hypoventilation (HP:0002791)2.12128445
70Neoplasm of the peripheral nervous system (HP:0100007)2.11714052
71Bradykinesia (HP:0002067)2.09362890
72Confusion (HP:0001289)2.09114788
73Genital tract atresia (HP:0001827)2.08139549
74Specific learning disability (HP:0001328)2.07958682
75Abnormality of the labia minora (HP:0012880)2.07050986
76Oligomenorrhea (HP:0000876)2.06754192
77Postural instability (HP:0002172)2.05800921
78Vaginal atresia (HP:0000148)2.05382388
79Progressive inability to walk (HP:0002505)2.05113727
80Drooling (HP:0002307)2.04811365
81Excessive salivation (HP:0003781)2.04811365
82Abnormality of renin-angiotensin system (HP:0000847)2.04275825
83Dynein arm defect of respiratory motile cilia (HP:0012255)2.02536928
84Absent/shortened dynein arms (HP:0200106)2.02536928
85Impaired pain sensation (HP:0007328)2.01499783
86Abnormality of pain sensation (HP:0010832)2.01499783
87Hypothermia (HP:0002045)2.01409201
88Craniofacial dystonia (HP:0012179)2.00861516
89Morphological abnormality of the pyramidal tract (HP:0002062)1.99472783
90Urinary urgency (HP:0000012)1.99225606
91Termporal pattern (HP:0011008)1.99010050
92Insidious onset (HP:0003587)1.99010050
93Absent speech (HP:0001344)1.97852103
94Bradycardia (HP:0001662)1.96109893
95Inability to walk (HP:0002540)1.94310529
96Cerebral hypomyelination (HP:0006808)1.93145901
97Turricephaly (HP:0000262)1.92696821
98Incomplete penetrance (HP:0003829)1.92636570
99Megalencephaly (HP:0001355)1.92279311
100Sudden death (HP:0001699)1.91300717
101Abnormality of the corticospinal tract (HP:0002492)1.89634055
102Blue irides (HP:0000635)1.88334526
103Abnormality of ocular smooth pursuit (HP:0000617)1.87606367
104Cerebral inclusion bodies (HP:0100314)1.87577681
105Poor coordination (HP:0002370)1.87428684
106Torticollis (HP:0000473)1.86936625
107Decreased central vision (HP:0007663)1.86810202
108Narrow nasal bridge (HP:0000446)1.86402183
109Hyperthyroidism (HP:0000836)1.85952992
110Abnormal ciliary motility (HP:0012262)1.85210158
111Lower limb muscle weakness (HP:0007340)1.84443419
112Syncope (HP:0001279)1.84400258
113Sleep apnea (HP:0010535)1.84343828
114Spastic gait (HP:0002064)1.83516661
115Heart block (HP:0012722)1.82725093
116Myotonia (HP:0002486)1.80573373
117Mitochondrial inheritance (HP:0001427)1.79625732
118Tetraplegia (HP:0002445)1.78903845
119Focal dystonia (HP:0004373)1.78820444
120Abnormal EKG (HP:0003115)1.78227874
121Stereotypic behavior (HP:0000733)1.78217701
122Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77587997
123Generalized myoclonic seizures (HP:0002123)1.77089758
124Abnormal respiratory epithelium morphology (HP:0012253)1.76672274
125Abnormal respiratory motile cilium morphology (HP:0005938)1.76672274
126Increased circulating renin level (HP:0000848)1.75169802
127Left ventricular hypertrophy (HP:0001712)1.74059809
128Delusions (HP:0000746)1.73565709
129Prolonged QT interval (HP:0001657)1.73300477
130Gait ataxia (HP:0002066)1.73262288
131Status epilepticus (HP:0002133)1.72404773
132Spastic tetraparesis (HP:0001285)1.71058766
133Congenital stationary night blindness (HP:0007642)1.65723274
134Degeneration of the lateral corticospinal tracts (HP:0002314)1.64005458
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.64005458
136Nephronophthisis (HP:0000090)1.63700518
137Aplasia involving bones of the extremities (HP:0009825)1.63663940
138Aplasia involving bones of the upper limbs (HP:0009823)1.63663940
139Aplasia of the phalanges of the hand (HP:0009802)1.63663940
140Shawl scrotum (HP:0000049)1.61682324
141Abnormal respiratory motile cilium physiology (HP:0012261)1.61439000
142Pendular nystagmus (HP:0012043)1.61280788

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.46129871
2NTRK33.92113252
3MAP3K123.47159892
4MAP3K43.23766745
5MAP2K73.12848161
6EPHA42.76931416
7MAP3K92.71475766
8MINK12.62473575
9PLK22.34594327
10DAPK22.33273427
11AKT32.24468250
12CDK192.13325528
13MAP2K42.07724977
14SIK31.84921114
15PRPF4B1.82308331
16MAPK151.73988793
17DAPK11.73540181
18MARK11.68946354
19GRK51.65267066
20ARAF1.63021263
21SGK21.60487833
22PRKD31.45801181
23SGK2231.42918270
24SGK4941.42918270
25TYRO31.39461938
26PAK61.37407624
27KSR11.34357727
28NTRK21.31294241
29OXSR11.28934603
30MAPK131.28309863
31PRKCG1.25559979
32NTRK11.20700060
33RIPK41.16174294
34CDK51.15752910
35PDK41.14249922
36PDK31.14249922
37BMPR21.13691279
38MARK21.13549697
39CAMKK11.12596834
40SIK21.12384731
41RIPK11.11712111
42CCNB11.11187748
43KSR21.09279121
44BCR1.08787703
45SGK31.08354536
46TSSK61.07539348
47MYLK1.07023629
48CAMKK21.04325073
49FRK1.04170320
50CAMK2A1.02167472
51NME10.99833660
52GRK10.96228963
53STK390.95285925
54STK380.94776368
55BRAF0.93906619
56DYRK20.92606833
57LMTK20.87522908
58FGFR20.86514542
59PKN10.83191313
60ALK0.82933990
61STK240.81180832
62PTK2B0.80436862
63CSNK1G20.79837319
64CAMK2B0.78676653
65MAPK120.78548453
66MAP2K60.76910580
67PHKG20.76817538
68PHKG10.76817538
69PRKCE0.76452594
70LATS20.76194547
71CDK180.75943807
72PRKCH0.73216638
73FER0.71417575
74PNCK0.69965859
75CDC42BPA0.69290304
76GRK70.69226949
77TNIK0.68801523
78OBSCN0.68556457
79PINK10.68388148
80UHMK10.67979302
81NEK10.66685943
82CAMK10.66326851
83CDK140.66090127
84WNK10.64276153
85CDK150.64040512
86MAP2K20.61810683
87SGK10.60032074
88PRKD20.59665586
89PAK30.59560939
90PDK20.58740120
91MAP3K20.58391548
92CAMK2D0.57614098
93CAMK2G0.57087894
94LATS10.57035618
95MAP2K10.56861918
96PRKCZ0.56439930
97DYRK1A0.55310707
98CAMK1G0.53472703
99STK38L0.53140154
100ADRBK10.53033716
101CDK11A0.51159321
102WNK30.50909076
103RPS6KA20.50828742
104CSNK1A10.50697053
105STK110.49196374
106DAPK30.49121982
107LIMK10.49032276
108CSNK1D0.47847911
109ERBB20.47209803
110MAP3K10.46344731
111ERBB30.45957062
112PDK10.45606082
113NEK60.44950735
114RAF10.43200351
115CSNK1A1L0.43005843
116MUSK0.42687250
117PDPK10.41919181
118MAPK100.41647432
119TAOK10.41008491
120PRKACA0.40907945
121PRKCA0.40722249
122WNK40.40668522
123FES0.40238065
124ROCK20.38329841
125TLK10.38060808
126ADRBK20.37388874
127PRKAA10.37205938
128RPS6KA30.36960199
129CAMK1D0.36587605
130CAMK40.36029886
131PRKD10.35468472
132MAPK80.34340605
133PRKG10.33721420

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.01753718
2Nicotine addiction_Homo sapiens_hsa050333.69023691
3Collecting duct acid secretion_Homo sapiens_hsa049662.82382705
4Olfactory transduction_Homo sapiens_hsa047402.82326762
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.54417162
6Circadian entrainment_Homo sapiens_hsa047132.49587251
7Long-term potentiation_Homo sapiens_hsa047202.47593688
8GABAergic synapse_Homo sapiens_hsa047272.46119696
9Amphetamine addiction_Homo sapiens_hsa050312.44179677
10Morphine addiction_Homo sapiens_hsa050322.30497376
11Glutamatergic synapse_Homo sapiens_hsa047242.18212401
12Dopaminergic synapse_Homo sapiens_hsa047282.10241988
13Taste transduction_Homo sapiens_hsa047422.07665143
14Insulin secretion_Homo sapiens_hsa049111.99260123
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94729523
16Vibrio cholerae infection_Homo sapiens_hsa051101.92680546
17Salivary secretion_Homo sapiens_hsa049701.90346453
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75148186
19Oxidative phosphorylation_Homo sapiens_hsa001901.73084933
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71731708
21Serotonergic synapse_Homo sapiens_hsa047261.64359662
22Gastric acid secretion_Homo sapiens_hsa049711.63850840
23Cholinergic synapse_Homo sapiens_hsa047251.59435722
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58637841
25Calcium signaling pathway_Homo sapiens_hsa040201.55163903
26Cardiac muscle contraction_Homo sapiens_hsa042601.51831485
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50151875
28Long-term depression_Homo sapiens_hsa047301.50103497
29Renin secretion_Homo sapiens_hsa049241.49851696
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.44952993
31Cocaine addiction_Homo sapiens_hsa050301.41380118
32Oxytocin signaling pathway_Homo sapiens_hsa049211.37838582
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.31088229
34Parkinsons disease_Homo sapiens_hsa050121.26955129
35Alzheimers disease_Homo sapiens_hsa050101.19990480
36GnRH signaling pathway_Homo sapiens_hsa049121.16770333
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14925949
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13579732
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11473808
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11199712
41cAMP signaling pathway_Homo sapiens_hsa040241.10735446
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09266062
43Gap junction_Homo sapiens_hsa045401.09043386
44Bile secretion_Homo sapiens_hsa049761.07140545
45Phototransduction_Homo sapiens_hsa047441.02457955
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02028229
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01407383
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96120297
49Dilated cardiomyopathy_Homo sapiens_hsa054140.95749555
50ErbB signaling pathway_Homo sapiens_hsa040120.94255780
51Type II diabetes mellitus_Homo sapiens_hsa049300.93089972
52Huntingtons disease_Homo sapiens_hsa050160.92451829
53Melanogenesis_Homo sapiens_hsa049160.91518633
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.88251987
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87930462
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87349114
57Axon guidance_Homo sapiens_hsa043600.86192257
58Estrogen signaling pathway_Homo sapiens_hsa049150.86176101
59Histidine metabolism_Homo sapiens_hsa003400.86171521
60Nitrogen metabolism_Homo sapiens_hsa009100.81991569
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78279855
62Oocyte meiosis_Homo sapiens_hsa041140.78145954
63Glioma_Homo sapiens_hsa052140.76512650
64Vitamin B6 metabolism_Homo sapiens_hsa007500.75763579
65Glucagon signaling pathway_Homo sapiens_hsa049220.70800865
66Rheumatoid arthritis_Homo sapiens_hsa053230.69584582
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68706986
68Thyroid hormone synthesis_Homo sapiens_hsa049180.67436578
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66486961
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65201520
71Pancreatic secretion_Homo sapiens_hsa049720.65105225
72Hippo signaling pathway_Homo sapiens_hsa043900.64672151
73Mineral absorption_Homo sapiens_hsa049780.64080156
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63745421
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63460640
76MAPK signaling pathway_Homo sapiens_hsa040100.60078716
77Pyruvate metabolism_Homo sapiens_hsa006200.59391075
78Arginine and proline metabolism_Homo sapiens_hsa003300.57559283
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.57109476
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56118813
81Type I diabetes mellitus_Homo sapiens_hsa049400.53637204
82Phagosome_Homo sapiens_hsa041450.53087731
83Ras signaling pathway_Homo sapiens_hsa040140.50201183
84beta-Alanine metabolism_Homo sapiens_hsa004100.49893483
85Dorso-ventral axis formation_Homo sapiens_hsa043200.49159166
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.47128508
87Circadian rhythm_Homo sapiens_hsa047100.46420115
88Inositol phosphate metabolism_Homo sapiens_hsa005620.45666275
89Protein digestion and absorption_Homo sapiens_hsa049740.44532944
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43671185
91ABC transporters_Homo sapiens_hsa020100.42719790
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41843163
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.41069639
94Tryptophan metabolism_Homo sapiens_hsa003800.40609842
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40177898
96Insulin signaling pathway_Homo sapiens_hsa049100.40027977
97Rap1 signaling pathway_Homo sapiens_hsa040150.39761923
98Endometrial cancer_Homo sapiens_hsa052130.37625357
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37378636
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.37337556
101Wnt signaling pathway_Homo sapiens_hsa043100.36139872
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35758451
103Melanoma_Homo sapiens_hsa052180.35150318
104Tight junction_Homo sapiens_hsa045300.35046249
105Alcoholism_Homo sapiens_hsa050340.34346038
106Ether lipid metabolism_Homo sapiens_hsa005650.32196466
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31413719
108Choline metabolism in cancer_Homo sapiens_hsa052310.30539808
109Basal cell carcinoma_Homo sapiens_hsa052170.29823082
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.29022569
111Linoleic acid metabolism_Homo sapiens_hsa005910.28962891
112Sphingolipid metabolism_Homo sapiens_hsa006000.28759862
113Endocytosis_Homo sapiens_hsa041440.28561589
114Arginine biosynthesis_Homo sapiens_hsa002200.27896559
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27852001
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27767208
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27498590
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27420319
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26894455
120Ovarian steroidogenesis_Homo sapiens_hsa049130.23056682
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22281370
122Hedgehog signaling pathway_Homo sapiens_hsa043400.20439617
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20227310

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