ARHGAP45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.60817818
2negative regulation of cell killing (GO:0031342)6.60817818
3positive regulation of gamma-delta T cell activation (GO:0046645)6.39364246
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.19766219
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.93118809
6antigen processing and presentation of endogenous antigen (GO:0019883)5.81988010
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.42153468
8regulation of B cell receptor signaling pathway (GO:0050855)5.06863449
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.81127723
10modulation by symbiont of host immune response (GO:0052553)4.81127723
11positive regulation by symbiont of host defense response (GO:0052509)4.81127723
12modulation by symbiont of host defense response (GO:0052031)4.81127723
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.81127723
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.81127723
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.77821826
16leukocyte aggregation (GO:0070486)4.73955631
17regulation of gamma-delta T cell activation (GO:0046643)4.71132711
18detection of bacterium (GO:0016045)4.63522965
19detection of other organism (GO:0098543)4.63490165
20negative thymic T cell selection (GO:0045060)4.60598278
21negative T cell selection (GO:0043383)4.51409946
22neutrophil activation involved in immune response (GO:0002283)4.48803866
23regulation of gamma-delta T cell differentiation (GO:0045586)4.47184691
24positive thymic T cell selection (GO:0045059)4.32457013
25response to interleukin-15 (GO:0070672)4.19735859
26negative regulation of lymphocyte mediated immunity (GO:0002707)4.18373515
27macrophage activation involved in immune response (GO:0002281)4.05039358
28cellular extravasation (GO:0045123)4.02996327
29B cell receptor signaling pathway (GO:0050853)4.00560349
30T cell selection (GO:0045058)3.91553614
31thymic T cell selection (GO:0045061)3.89819965
32response to peptidoglycan (GO:0032494)3.88699119
33positive T cell selection (GO:0043368)3.87243958
34T cell migration (GO:0072678)3.86779964
35negative regulation of T cell mediated immunity (GO:0002710)3.85243003
36tolerance induction (GO:0002507)3.84331971
37negative regulation of erythrocyte differentiation (GO:0045647)3.83103053
38negative regulation of interleukin-12 production (GO:0032695)3.81728470
39immunoglobulin mediated immune response (GO:0016064)3.78620717
40negative regulation of leukocyte mediated immunity (GO:0002704)3.78246262
41regulation of B cell differentiation (GO:0045577)3.75271143
42positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.75112980
43positive regulation of B cell differentiation (GO:0045579)3.74657913
44cellular response to interleukin-15 (GO:0071350)3.72780161
45response to muramyl dipeptide (GO:0032495)3.70336642
46regulation of T cell tolerance induction (GO:0002664)3.70306960
47respiratory burst (GO:0045730)3.68126806
48detection of external biotic stimulus (GO:0098581)3.64072931
49regulation of interferon-beta biosynthetic process (GO:0045357)3.57133407
50neutrophil activation (GO:0042119)3.54428707
51positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.50880144
52negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.45936466
53activated T cell proliferation (GO:0050798)3.43079274
54regulation of tolerance induction (GO:0002643)3.42618071
55type I interferon signaling pathway (GO:0060337)3.41692162
56cellular response to type I interferon (GO:0071357)3.41692162
57response to type I interferon (GO:0034340)3.40495170
58antigen processing and presentation via MHC class Ib (GO:0002475)3.39101504
59negative regulation of phagocytosis (GO:0050765)3.38245223
60regulation of alpha-beta T cell proliferation (GO:0046640)3.37672903
61myeloid cell activation involved in immune response (GO:0002275)3.35491546
62regulation of mast cell degranulation (GO:0043304)3.34583913
63granulocyte activation (GO:0036230)3.23441186
64regulation of dendritic cell antigen processing and presentation (GO:0002604)3.22883028
65response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.22752446
66response to host immune response (GO:0052572)3.22752446
67defense response to protozoan (GO:0042832)3.22567418
68germinal center formation (GO:0002467)3.20529902
69detection of biotic stimulus (GO:0009595)3.19261930
70regulation of natural killer cell mediated immunity (GO:0002715)3.17076862
71regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.17076862
72positive regulation of granulocyte differentiation (GO:0030854)3.16717768
73regulation of myeloid leukocyte mediated immunity (GO:0002886)3.12266187
74negative regulation of innate immune response (GO:0045824)3.09582837
75regulation of T cell mediated cytotoxicity (GO:0001914)3.08960608
76interferon-gamma-mediated signaling pathway (GO:0060333)3.08254122
77leukocyte degranulation (GO:0043299)3.06365845
78regulation of mast cell activation involved in immune response (GO:0033006)3.05132851
79regulation of leukocyte degranulation (GO:0043300)3.04921510
80response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.02685089
81response to host (GO:0075136)3.02685089
82response to host defenses (GO:0052200)3.02685089
83antigen receptor-mediated signaling pathway (GO:0050851)3.01735472
84negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.00986619
85negative regulation of T-helper cell differentiation (GO:0045623)3.00986619
86NIK/NF-kappaB signaling (GO:0038061)3.00855657
87positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.00442185
88B cell mediated immunity (GO:0019724)2.99226412
89leukocyte migration involved in inflammatory response (GO:0002523)2.98934592
90microglial cell activation (GO:0001774)2.97670283
91T cell homeostasis (GO:0043029)2.97583422
92response to protozoan (GO:0001562)2.96234871
93regulation of antigen processing and presentation (GO:0002577)2.95602983
94positive regulation of T cell mediated cytotoxicity (GO:0001916)2.95120556
95regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.93035602
96regulation of regulatory T cell differentiation (GO:0045589)2.92500461
97detection of molecule of bacterial origin (GO:0032490)2.90521161
98positive regulation of mast cell activation (GO:0033005)2.89779767
99positive regulation of tolerance induction (GO:0002645)2.89306982
100production of molecular mediator involved in inflammatory response (GO:0002532)2.87320078

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.17823279
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.19732890
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.63691070
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.53380291
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.41709577
6VDR_21846776_ChIP-Seq_THP-1_Human3.32283238
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.31046535
8MYC_22102868_ChIP-Seq_BL_Human3.25180215
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88995294
10RUNX_20019798_ChIP-Seq_JUKART_Human2.86505257
11VDR_24763502_ChIP-Seq_THP-1_Human2.74492269
12MAF_26560356_Chip-Seq_TH1_Human2.74482780
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.63466523
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.63371640
15MYB_26560356_Chip-Seq_TH2_Human2.61186791
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.60251525
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.55511678
18E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.53620213
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53530034
20UTX_26944678_Chip-Seq_JUKART_Human2.52354913
21SPI1_23547873_ChIP-Seq_NB4_Human2.48564067
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.44536534
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43317832
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.41200399
25SCL_19346495_ChIP-Seq_HPC-7_Human2.39680149
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.36788836
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.34829398
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.32048226
29MYB_26560356_Chip-Seq_TH1_Human2.31874491
30TCF7_22412390_ChIP-Seq_EML_Mouse2.31809684
31KDM2B_26808549_Chip-Seq_SUP-B15_Human2.26894540
32STAT4_19710469_ChIP-ChIP_TH1__Mouse2.26225676
33SPI1_23127762_ChIP-Seq_K562_Human2.23493816
34MAF_26560356_Chip-Seq_TH2_Human2.17741354
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11541551
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.10864899
37BRD4_27068464_Chip-Seq_AML-cells_Mouse2.10666440
38KDM2B_26808549_Chip-Seq_DND41_Human2.09136418
39EGR1_19374776_ChIP-ChIP_THP-1_Human2.07445827
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.99044969
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91141131
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.87983002
43GATA3_27048872_Chip-Seq_THYMUS_Human1.74941212
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67900850
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.65534510
46LXR_22292898_ChIP-Seq_THP-1_Human1.57378080
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57327033
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.56080631
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53161770
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51229827
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51094667
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.48104330
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47429279
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.47060733
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43701363
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43386217
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39922579
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38418346
59VDR_24787735_ChIP-Seq_THP-1_Human1.38076910
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32219422
61GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32042811
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30869798
63PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30249919
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27366503
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27346578
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27024962
67CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26880833
68PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26310956
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24712384
70CIITA_25753668_ChIP-Seq_RAJI_Human1.24501323
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22345707
72GATA3_26560356_Chip-Seq_TH2_Human1.21981305
73PU_27001747_Chip-Seq_BMDM_Mouse1.20834858
74GATA1_19941826_ChIP-Seq_K562_Human1.20613983
75BCL6_27268052_Chip-Seq_Bcells_Human1.19622927
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19117678
77BCOR_27268052_Chip-Seq_Bcells_Human1.15899684
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14468618
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14385705
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12842517
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11624722
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11299050
83NCOR1_26117541_ChIP-Seq_K562_Human1.10601050
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08557614
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07372931
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07052714
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03144947
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.01924275
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00876252
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.00849829
91RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00749970
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99821939
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99666697
94SMAD_19615063_ChIP-ChIP_OVARY_Human0.97326341
95GATA1_22025678_ChIP-Seq_K562_Human0.95049624
96P68_20966046_ChIP-Seq_HELA_Human0.93747166
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92493536
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89845174
99RACK7_27058665_Chip-Seq_MCF-7_Human0.86144222
100GATA2_19941826_ChIP-Seq_K562_Human0.83455870

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.23592364
2MP0003724_increased_susceptibility_to3.91352764
3MP0001835_abnormal_antigen_presentation3.76408591
4MP0003303_peritoneal_inflammation3.45934519
5MP0003763_abnormal_thymus_physiology3.38027755
6MP0005671_abnormal_response_to3.30973623
7MP0001800_abnormal_humoral_immune3.22557489
8MP0005387_immune_system_phenotype3.02565958
9MP0001790_abnormal_immune_system3.02565958
10MP0000685_abnormal_immune_system3.01302068
11MP0005000_abnormal_immune_tolerance2.97645294
12MP0002419_abnormal_innate_immunity2.91478680
13MP0005025_abnormal_response_to2.83896886
14MP0002723_abnormal_immune_serum2.73981326
15MP0002420_abnormal_adaptive_immunity2.72451805
16MP0001819_abnormal_immune_cell2.69273841
17MP0002452_abnormal_antigen_presenting2.66023918
18MP0003300_gastrointestinal_ulcer2.56352326
19MP0009785_altered_susceptibility_to2.51074914
20MP0006082_CNS_inflammation2.39876700
21MP0002398_abnormal_bone_marrow2.27885466
22MP0009333_abnormal_splenocyte_physiolog2.16528220
23MP0002405_respiratory_system_inflammati2.16496291
24MP0002148_abnormal_hypersensitivity_rea2.16147625
25MP0000716_abnormal_immune_system2.13658850
26MP0005464_abnormal_platelet_physiology2.13489033
27MP0010155_abnormal_intestine_physiology2.00725917
28MP0002396_abnormal_hematopoietic_system2.00673319
29MP0001533_abnormal_skeleton_physiology1.95239059
30MP0003172_abnormal_lysosome_physiology1.91936914
31MP0000689_abnormal_spleen_morphology1.89670155
32MP0000703_abnormal_thymus_morphology1.89537291
33MP0004947_skin_inflammation1.86509205
34MP0002722_abnormal_immune_system1.86238330
35MP0009278_abnormal_bone_marrow1.77737219
36MP0008260_abnormal_autophagy1.76629453
37MP0003866_abnormal_defecation1.74663805
38MP0001845_abnormal_inflammatory_respons1.74043371
39MP0000465_gastrointestinal_hemorrhage1.73153380
40MP0003191_abnormal_cellular_cholesterol1.72073092
41MP0002429_abnormal_blood_cell1.71866891
42MP0001873_stomach_inflammation1.62145085
43MP0004381_abnormal_hair_follicle1.55272589
44MP0005310_abnormal_salivary_gland1.52805275
45MP0002132_abnormal_respiratory_system1.47360350
46MP0005451_abnormal_body_composition1.44720329
47MP0001851_eye_inflammation1.44486615
48MP0003828_pulmonary_edema1.44153008
49MP0008469_abnormal_protein_level1.38375022
50MP0005058_abnormal_lysosome_morphology1.29813781
51MP0002166_altered_tumor_susceptibility1.28619734
52MP0000858_altered_metastatic_potential1.28404222
53MP0003183_abnormal_peptide_metabolism1.25854846
54MP0005397_hematopoietic_system_phenotyp1.22091592
55MP0001545_abnormal_hematopoietic_system1.22091592
56MP0004510_myositis1.21760530
57MP0002998_abnormal_bone_remodeling1.21028118
58MP0002933_joint_inflammation1.11881971
59MP0009764_decreased_sensitivity_to1.10471224
60MP0001853_heart_inflammation1.09465766
61MP0004883_abnormal_blood_vessel1.08823910
62MP0005075_abnormal_melanosome_morpholog1.08550347
63MP0002009_preneoplasia1.05698645
64MP0000490_abnormal_crypts_of1.04693350
65MP0002138_abnormal_hepatobiliary_system1.02533000
66MP0004808_abnormal_hematopoietic_stem1.02137063
67MP0002277_abnormal_respiratory_mucosa0.96151770
68MP0001663_abnormal_digestive_system0.92814793
69MP0003690_abnormal_glial_cell0.85450772
70MP0001986_abnormal_taste_sensitivity0.85213986
71MP0005166_decreased_susceptibility_to0.83260496
72MP0003075_altered_response_to0.81118068
73MP0003448_altered_tumor_morphology0.78695767
74MP0009763_increased_sensitivity_to0.77704605
75MP0002006_tumorigenesis0.76380513
76MP0005390_skeleton_phenotype0.76165551
77MP0008004_abnormal_stomach_pH0.75446923
78MP0005164_abnormal_response_to0.72026237
79MP0009840_abnormal_foam_cell0.68988762
80MP0000604_amyloidosis0.68468730
81MP0002019_abnormal_tumor_incidence0.67997155
82MP0000015_abnormal_ear_pigmentation0.67830138
83MP0003091_abnormal_cell_migration0.67164843
84MP0003656_abnormal_erythrocyte_physiolo0.64503407
85MP0000249_abnormal_blood_vessel0.63958531
86MP0004130_abnormal_muscle_cell0.63173821
87MP0003795_abnormal_bone_structure0.62302888
88MP0003045_fibrosis0.61707514
89MP0005076_abnormal_cell_differentiation0.60851256
90MP0008874_decreased_physiological_sensi0.59450145
91MP0009765_abnormal_xenobiotic_induced0.58839876
92MP0000343_altered_response_to0.57081835
93MP0005381_digestive/alimentary_phenotyp0.51477533
94MP0002693_abnormal_pancreas_physiology0.49456048
95MP0004185_abnormal_adipocyte_glucose0.48427850
96MP0003453_abnormal_keratinocyte_physiol0.48147647
97MP0008961_abnormal_basal_metabolism0.46734507
98MP0003221_abnormal_cardiomyocyte_apopto0.45993831
99MP0000609_abnormal_liver_physiology0.44670329
100MP0009115_abnormal_fat_cell0.42135338

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.68201040
2Recurrent abscess formation (HP:0002722)5.52007726
3Recurrent bacterial skin infections (HP:0005406)5.49758461
4Myositis (HP:0100614)5.14186901
5Abnormality of macrophages (HP:0004311)4.96659479
6Stomatitis (HP:0010280)4.69868198
7Elevated erythrocyte sedimentation rate (HP:0003565)4.59651151
8Orchitis (HP:0100796)4.46013699
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.40965028
10Recurrent fungal infections (HP:0002841)4.39695314
11Recurrent gram-negative bacterial infections (HP:0005420)4.29320117
12Optic neuritis (HP:0100653)4.24325912
13Retrobulbar optic neuritis (HP:0100654)4.24325912
14Meningitis (HP:0001287)4.22824670
15Mediastinal lymphadenopathy (HP:0100721)4.16457422
16Chronic obstructive pulmonary disease (HP:0006510)3.96899630
17Obstructive lung disease (HP:0006536)3.96899630
18Gastrointestinal infarctions (HP:0005244)3.90751603
19Increased IgE level (HP:0003212)3.81959361
20Panhypogammaglobulinemia (HP:0003139)3.81498014
21Recurrent skin infections (HP:0001581)3.75204527
22Pustule (HP:0200039)3.73609790
23Chronic mucocutaneous candidiasis (HP:0002728)3.64754423
24Recurrent cutaneous fungal infections (HP:0011370)3.64754423
25Encephalitis (HP:0002383)3.64413126
26Spontaneous hematomas (HP:0007420)3.63946505
27T lymphocytopenia (HP:0005403)3.62069890
28Vasculitis (HP:0002633)3.58325042
29Prolonged bleeding time (HP:0003010)3.55659176
30Cellulitis (HP:0100658)3.48517816
31Recurrent viral infections (HP:0004429)3.47289281
32Abnormality of T cell number (HP:0011839)3.38895946
33Inflammation of the large intestine (HP:0002037)3.32414533
34Gastrointestinal inflammation (HP:0004386)3.29761448
35Gingivitis (HP:0000230)3.20237891
36Agammaglobulinemia (HP:0004432)3.16189687
37Abnormality of T cells (HP:0002843)3.15918678
38Chest pain (HP:0100749)3.10233083
39Urticaria (HP:0001025)3.09277679
40Colitis (HP:0002583)3.07249829
41Keratoconjunctivitis sicca (HP:0001097)3.04944068
42Lymphopenia (HP:0001888)3.02147593
43Pulmonary infiltrates (HP:0002113)2.91697678
44Hypochromic anemia (HP:0001931)2.90897598
45Granulocytopenia (HP:0001913)2.90306646
46Epistaxis (HP:0000421)2.86398011
47Leukocytosis (HP:0001974)2.83247401
48Keratoconjunctivitis (HP:0001096)2.82096557
49Abnormality of cells of the lymphoid lineage (HP:0012140)2.80814851
50IgM deficiency (HP:0002850)2.78853688
51Hypochromic microcytic anemia (HP:0004840)2.77351189
52Hemoptysis (HP:0002105)2.75084698
53Abnormality of T cell physiology (HP:0011840)2.71933968
54Osteomyelitis (HP:0002754)2.66746560
55Gastrointestinal stroma tumor (HP:0100723)2.63357538
56Increased IgM level (HP:0003496)2.62989932
57Papilloma (HP:0012740)2.59749079
58Verrucae (HP:0200043)2.59749079
59Petechiae (HP:0000967)2.55942107
60Gingival bleeding (HP:0000225)2.54828655
61Episodic fever (HP:0001954)2.49980457
62Recurrent bronchitis (HP:0002837)2.46097867
63Pulmonary embolism (HP:0002204)2.43711379
64Sepsis (HP:0100806)2.41783448
65Arterial thrombosis (HP:0004420)2.37456373
66Anorexia (HP:0002039)2.30339955
67Hypergammaglobulinemia (HP:0010702)2.29365471
68Autoimmune hemolytic anemia (HP:0001890)2.29343104
69Eosinophilia (HP:0001880)2.28624967
70Severe combined immunodeficiency (HP:0004430)2.24778576
71Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.24294151
72Viral hepatitis (HP:0006562)2.22112331
73Recurrent sinusitis (HP:0011108)2.20633093
74Purpura (HP:0000979)2.18738743
75Microcytic anemia (HP:0001935)2.17054483
76Slow saccadic eye movements (HP:0000514)2.16336227
77Abnormality of the pleura (HP:0002103)2.12892112
78Skin ulcer (HP:0200042)2.12152904
79Abnormality of the fingertips (HP:0001211)2.11457129
80Restrictive lung disease (HP:0002091)2.09605798
81Papilledema (HP:0001085)2.07378598
82Increased cerebral lipofuscin (HP:0011813)2.05461922
83Abnormality of eosinophils (HP:0001879)2.03607743
84IgG deficiency (HP:0004315)2.00437484
85Premature loss of primary teeth (HP:0006323)2.00252217
86Abnormal platelet volume (HP:0011876)1.98583801
87Chronic otitis media (HP:0000389)1.97877328
88Increased serum ferritin (HP:0003281)1.96503374
89Recurrent pneumonia (HP:0006532)1.96458739
90Hepatosplenomegaly (HP:0001433)1.95863278
91Amyloidosis (HP:0011034)1.95808897
92Autoimmune thrombocytopenia (HP:0001973)1.95758540
93Glomerulopathy (HP:0100820)1.94037000
94Gangrene (HP:0100758)1.93883596
95Loss of speech (HP:0002371)1.92238312
96Abnormality of the peritoneum (HP:0002585)1.89176134
97Combined immunodeficiency (HP:0005387)1.88277929
98Recurrent lower respiratory tract infections (HP:0002783)1.87974771
99Skin rash (HP:0000988)1.86752371
100Acute hepatic failure (HP:0006554)1.85912664

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.62880026
2RIPK44.13409766
3PRPF4B3.24317582
4TYK22.75392848
5BLK2.68176152
6ERN12.65702831
7IRAK42.52744824
8FES2.49980733
9MAP2K32.38818974
10GRK62.36902169
11TNK22.32335437
12CSK2.25908970
13TXK2.17293298
14ZAP702.15251955
15BTK2.06663677
16MAP3K131.90474530
17MAP3K141.82538602
18JAK31.81429837
19SYK1.77418194
20IKBKE1.74946554
21HCK1.69623550
22SIK31.60857675
23EPHB11.56463827
24TBK11.53201344
25TRIB31.46858798
26ITK1.46564515
27TAOK11.45707719
28JAK11.44213713
29MAP3K31.38168013
30MAP3K101.35759822
31LCK1.35604434
32MAP3K111.35554482
33LYN1.33903474
34TAOK31.32918508
35SIK21.28307479
36CSF1R1.27805965
37FGR1.26952106
38SMG11.24432525
39MARK31.18321414
40JAK21.14691580
41MARK21.11683185
42TEC1.11519587
43MAP3K11.11013898
44KIT1.10065678
45IKBKB1.04180545
46FGFR40.98102916
47STK100.94315682
48PRKD20.91524006
49TESK20.89844185
50SIK10.89294257
51KSR20.88754472
52PDK10.88602497
53MAPK120.83826431
54TAOK20.82303131
55MAP3K70.81707899
56CDC42BPA0.79584443
57YES10.78918870
58HIPK20.78633977
59CDK120.78489399
60PTK60.77769345
61PASK0.75291752
62NLK0.75046022
63CAMKK10.74775006
64FGFR30.73712889
65PRKCQ0.72677757
66MAPK70.72445469
67CDK40.69314393
68BMPR20.67312281
69PIM10.66182461
70PDPK10.65421527
71IRAK10.62107225
72FYN0.59506093
73LRRK20.59453936
74IRAK20.58550841
75CAMKK20.56322785
76TGFBR20.53969328
77RPS6KL10.51320114
78RPS6KC10.51320114
79MAP2K20.51184417
80DYRK1B0.50558862
81CDK190.49260337
82MATK0.49064511
83MAPK110.47610576
84STK110.44228708
85CDK60.42698984
86RET0.42352769
87RPS6KA60.42041399
88SGK30.40377366
89MAP3K60.37824410
90PIK3CG0.36828228
91PTK2B0.35336091
92PRKCH0.34165302
93STK380.33902075
94PKN20.33496186
95MELK0.32366372
96MAPKAPK20.32262509
97MAPK40.29124885
98BMX0.28836014
99MAP3K50.28257768
100MAP3K80.27669611

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.02230824
2Osteoclast differentiation_Homo sapiens_hsa043802.73906352
3Allograft rejection_Homo sapiens_hsa053302.73472758
4Leishmaniasis_Homo sapiens_hsa051402.70508522
5Graft-versus-host disease_Homo sapiens_hsa053322.67607376
6Autoimmune thyroid disease_Homo sapiens_hsa053202.58200642
7B cell receptor signaling pathway_Homo sapiens_hsa046622.57680495
8Staphylococcus aureus infection_Homo sapiens_hsa051502.35486850
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.29199076
10T cell receptor signaling pathway_Homo sapiens_hsa046602.10351332
11Type I diabetes mellitus_Homo sapiens_hsa049401.97849080
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97589457
13Acute myeloid leukemia_Homo sapiens_hsa052211.96994114
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.91987858
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.87780226
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.84418853
17Tuberculosis_Homo sapiens_hsa051521.83367332
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82229628
19Antigen processing and presentation_Homo sapiens_hsa046121.81496210
20Measles_Homo sapiens_hsa051621.80257240
21Viral myocarditis_Homo sapiens_hsa054161.77846114
22Hematopoietic cell lineage_Homo sapiens_hsa046401.76060407
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.71697621
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58835997
25Other glycan degradation_Homo sapiens_hsa005111.57937171
26Asthma_Homo sapiens_hsa053101.57192727
27Chemokine signaling pathway_Homo sapiens_hsa040621.54934858
28Toxoplasmosis_Homo sapiens_hsa051451.53893874
29Herpes simplex infection_Homo sapiens_hsa051681.52786584
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51274158
31Influenza A_Homo sapiens_hsa051641.49540188
32Malaria_Homo sapiens_hsa051441.45078050
33Non-small cell lung cancer_Homo sapiens_hsa052231.38412155
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.35263196
35TNF signaling pathway_Homo sapiens_hsa046681.25740330
36Hepatitis B_Homo sapiens_hsa051611.24155600
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21096892
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20051358
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.18326503
40Platelet activation_Homo sapiens_hsa046111.16085088
41Chronic myeloid leukemia_Homo sapiens_hsa052201.11392076
42Pancreatic cancer_Homo sapiens_hsa052121.09156487
43Legionellosis_Homo sapiens_hsa051341.06697172
44VEGF signaling pathway_Homo sapiens_hsa043701.04406453
45Hepatitis C_Homo sapiens_hsa051601.04227631
46Phagosome_Homo sapiens_hsa041451.01770620
47African trypanosomiasis_Homo sapiens_hsa051430.97146735
48Apoptosis_Homo sapiens_hsa042100.96466247
49Rheumatoid arthritis_Homo sapiens_hsa053230.91931791
50Epstein-Barr virus infection_Homo sapiens_hsa051690.91027773
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89767947
52Shigellosis_Homo sapiens_hsa051310.87724143
53Pertussis_Homo sapiens_hsa051330.86425688
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84732752
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.84418713
56Renal cell carcinoma_Homo sapiens_hsa052110.83421163
57HTLV-I infection_Homo sapiens_hsa051660.81900752
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81417713
59Prolactin signaling pathway_Homo sapiens_hsa049170.80467220
60Viral carcinogenesis_Homo sapiens_hsa052030.79855979
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79498902
62Colorectal cancer_Homo sapiens_hsa052100.79426655
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77684473
64Endometrial cancer_Homo sapiens_hsa052130.76827281
65Notch signaling pathway_Homo sapiens_hsa043300.75008666
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.73562944
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73373973
68Choline metabolism in cancer_Homo sapiens_hsa052310.72751594
69FoxO signaling pathway_Homo sapiens_hsa040680.70101552
70Endocytosis_Homo sapiens_hsa041440.70091758
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.68800774
72Salmonella infection_Homo sapiens_hsa051320.67568160
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66901657
74Inositol phosphate metabolism_Homo sapiens_hsa005620.65873178
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63753540
76mTOR signaling pathway_Homo sapiens_hsa041500.63143559
77Lysosome_Homo sapiens_hsa041420.63033839
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.57557384
79GnRH signaling pathway_Homo sapiens_hsa049120.57254608
80MAPK signaling pathway_Homo sapiens_hsa040100.51141465
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50941285
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50470379
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49973821
84Insulin resistance_Homo sapiens_hsa049310.49778833
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.49719555
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.49637549
87HIF-1 signaling pathway_Homo sapiens_hsa040660.48434849
88Prostate cancer_Homo sapiens_hsa052150.46817997
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46789560
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43862682
91ErbB signaling pathway_Homo sapiens_hsa040120.42955488
92Dorso-ventral axis formation_Homo sapiens_hsa043200.41254244
93Type II diabetes mellitus_Homo sapiens_hsa049300.38254574
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38066248
95Rap1 signaling pathway_Homo sapiens_hsa040150.36959045
96Amoebiasis_Homo sapiens_hsa051460.36227407
97Thyroid cancer_Homo sapiens_hsa052160.35792374
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34845880
99Glioma_Homo sapiens_hsa052140.33027201
100Regulation of autophagy_Homo sapiens_hsa041400.32980369

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