ARHGAP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)3.64979618
2protein targeting to Golgi (GO:0000042)3.37492944
3presynaptic membrane organization (GO:0097090)3.34304013
4establishment of protein localization to Golgi (GO:0072600)3.09586934
5embryonic foregut morphogenesis (GO:0048617)2.92428627
6retrograde transport, vesicle recycling within Golgi (GO:0000301)2.90088853
7positive regulation of dendritic spine morphogenesis (GO:0061003)2.81269131
8locomotory exploration behavior (GO:0035641)2.76414605
9central nervous system myelination (GO:0022010)2.76294276
10axon ensheathment in central nervous system (GO:0032291)2.76294276
11positive regulation of fatty acid beta-oxidation (GO:0032000)2.75223389
12cellular potassium ion homeostasis (GO:0030007)2.73142585
13vascular smooth muscle contraction (GO:0014829)2.72308811
14positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.72250127
15cerebellar Purkinje cell differentiation (GO:0021702)2.64971365
16insulin-like growth factor receptor signaling pathway (GO:0048009)2.61571669
17cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.61344370
18retina layer formation (GO:0010842)2.61086163
19dendrite morphogenesis (GO:0048813)2.60338853
20nucleus localization (GO:0051647)2.56703678
21relaxation of cardiac muscle (GO:0055119)2.55554555
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.53230575
23cell communication by electrical coupling (GO:0010644)2.52767727
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.52277963
25detection of calcium ion (GO:0005513)2.50711774
26glutamate secretion (GO:0014047)2.49650258
27establishment of nucleus localization (GO:0040023)2.46782069
28inner ear receptor cell development (GO:0060119)2.46700786
29macroautophagy (GO:0016236)2.46442916
30negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46189849
31neuronal stem cell maintenance (GO:0097150)2.45105109
32regulation of short-term neuronal synaptic plasticity (GO:0048172)2.44656202
33positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.44369627
34short-term memory (GO:0007614)2.42805730
35positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.41179742
36regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.41149627
37renal tubule morphogenesis (GO:0061333)2.41124427
38innervation (GO:0060384)2.40741099
39positive regulation of fatty acid oxidation (GO:0046321)2.40392540
40regulation of cell communication by electrical coupling (GO:0010649)2.39244491
41interkinetic nuclear migration (GO:0022027)2.36564224
42alanine transport (GO:0032328)2.36223062
43negative regulation of dendrite morphogenesis (GO:0050774)2.35450485
44otic vesicle formation (GO:0030916)2.34591103
45positive regulation of glycogen biosynthetic process (GO:0045725)2.34474755
46regulation of transforming growth factor beta2 production (GO:0032909)2.34383682
47COPI coating of Golgi vesicle (GO:0048205)2.33225296
48Golgi transport vesicle coating (GO:0048200)2.33225296
49cochlea development (GO:0090102)2.33106077
50regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.32882466
51G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.32818011
52cellular response to cholesterol (GO:0071397)2.31940781
53asymmetric protein localization (GO:0008105)2.31395363
54cellular response to sterol (GO:0036315)2.30597188
55membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.30476997
56artery development (GO:0060840)2.30057654
57anatomical structure arrangement (GO:0048532)2.29314994
58gastrulation with mouth forming second (GO:0001702)2.28888751
59positive regulation of cardiac muscle hypertrophy (GO:0010613)2.28687713
60positive regulation of muscle hypertrophy (GO:0014742)2.28687713
61regulation of dendritic spine morphogenesis (GO:0061001)2.28510853
62musculoskeletal movement (GO:0050881)2.28250706
63multicellular organismal movement (GO:0050879)2.28250706
64anterior/posterior axis specification, embryo (GO:0008595)2.27797925
65apical protein localization (GO:0045176)2.27649724
66layer formation in cerebral cortex (GO:0021819)2.27353141
67protein targeting to vacuole (GO:0006623)2.27025092
68protein targeting to lysosome (GO:0006622)2.27025092
69establishment of protein localization to vacuole (GO:0072666)2.27025092
70synaptic vesicle maturation (GO:0016188)2.26145816
71paraxial mesoderm development (GO:0048339)2.26065690
72cerebellar granule cell differentiation (GO:0021707)2.23935131
73negative regulation of neurotransmitter transport (GO:0051589)2.23635830
74regulation of cardiac muscle cell contraction (GO:0086004)2.23401379
75postsynaptic membrane organization (GO:0001941)2.22490782
76regulation of non-canonical Wnt signaling pathway (GO:2000050)2.22060553
77positive regulation of potassium ion transport (GO:0043268)2.21938737
78nephron tubule morphogenesis (GO:0072078)2.21609364
79nephron epithelium morphogenesis (GO:0072088)2.21609364
80regulation of synaptic vesicle exocytosis (GO:2000300)2.19885998
81positive regulation of neurological system process (GO:0031646)2.19883464
82membrane repolarization during action potential (GO:0086011)2.18822611
83neuron recognition (GO:0008038)2.16860801
84embryonic retina morphogenesis in camera-type eye (GO:0060059)2.16475119
85chemosensory behavior (GO:0007635)2.16438137
86negative regulation of dendrite development (GO:2000171)2.16265060
87notochord development (GO:0030903)2.16171802
88neurotransmitter secretion (GO:0007269)2.16081482
89bundle of His cell to Purkinje myocyte communication (GO:0086069)2.15340826
90metanephric nephron tubule development (GO:0072234)2.15338259
91metanephric tubule development (GO:0072170)2.15338259
92neuron cell-cell adhesion (GO:0007158)2.14632844
93positive regulation of catenin import into nucleus (GO:0035413)2.14502669
94dorsal/ventral axis specification (GO:0009950)2.14119494
95regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.14108224
96limb bud formation (GO:0060174)2.13859971
97negative regulation of sodium ion transport (GO:0010766)2.13599822
98regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.12837857
99regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.12835848
100regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.12102700
101retinal rod cell development (GO:0046548)2.12078731
102axonal fasciculation (GO:0007413)2.11851083
103regulation of cardioblast differentiation (GO:0051890)2.11782944
104negative regulation of hormone metabolic process (GO:0032351)2.11044779
105negative regulation of hormone biosynthetic process (GO:0032353)2.11044779
106membrane assembly (GO:0071709)2.10841032
107cell communication involved in cardiac conduction (GO:0086065)2.10746408
108regulation of protein polyubiquitination (GO:1902914)2.10372402
109gamma-aminobutyric acid transport (GO:0015812)2.09843346
110gamma-aminobutyric acid signaling pathway (GO:0007214)2.09602721
111negative regulation of neurotransmitter secretion (GO:0046929)2.09302922
112lactate metabolic process (GO:0006089)2.09190716
113sodium ion export (GO:0071436)2.08449351
114L-amino acid import (GO:0043092)2.08416889
115potassium ion import (GO:0010107)2.06025584
116cell-cell signaling involved in cell fate commitment (GO:0045168)2.06002639
117chondrocyte development (GO:0002063)2.05876629
118protein localization to Golgi apparatus (GO:0034067)2.05394912
119regulation of fatty acid beta-oxidation (GO:0031998)2.04693544
120cellular sodium ion homeostasis (GO:0006883)2.04525688
121ventricular cardiac muscle cell action potential (GO:0086005)2.04487712
122midgut development (GO:0007494)2.04207727
123regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.04164381
124insulin secretion (GO:0030073)2.04111202
125glutamate receptor signaling pathway (GO:0007215)2.03296794
126negative regulation of astrocyte differentiation (GO:0048712)2.03151944
127positive regulation of glycogen metabolic process (GO:0070875)2.02250644
128C4-dicarboxylate transport (GO:0015740)2.01968868
129long-term synaptic potentiation (GO:0060291)2.01564860
130positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.01560707
131endocrine pancreas development (GO:0031018)2.01429561
132positive regulation of glycolytic process (GO:0045821)2.01360458
133amino acid import (GO:0043090)2.01257943
134relaxation of muscle (GO:0090075)1.99900288
135glial cell proliferation (GO:0014009)1.99712862
136Golgi to endosome transport (GO:0006895)1.99345306
137relaxation of smooth muscle (GO:0044557)1.98862098
138genitalia morphogenesis (GO:0035112)1.98694071
139COPII vesicle coating (GO:0048208)1.98528651
140vesicle transport along microtubule (GO:0047496)1.98362081
141ectodermal placode formation (GO:0060788)1.98348472
142proline transport (GO:0015824)1.98210968
143cerebral cortex radially oriented cell migration (GO:0021799)1.97608673
144negative regulation of keratinocyte proliferation (GO:0010839)1.97395851
145regulation of potassium ion transmembrane transport (GO:1901379)1.97389019
146intra-Golgi vesicle-mediated transport (GO:0006891)1.95528715
147camera-type eye morphogenesis (GO:0048593)1.94804036
148developmental induction (GO:0031128)1.94432452
149cell differentiation in hindbrain (GO:0021533)1.94185886
150dendritic spine morphogenesis (GO:0060997)1.93518818
151peptide hormone processing (GO:0016486)1.93129157
152photoreceptor cell differentiation (GO:0046530)1.92574996
153eye photoreceptor cell differentiation (GO:0001754)1.92574996
154exocrine pancreas development (GO:0031017)1.92130138
155G-protein coupled glutamate receptor signaling pathway (GO:0007216)1.91915505
156response to auditory stimulus (GO:0010996)1.91883009
157homocysteine metabolic process (GO:0050667)1.91642761
158neurotransmitter-gated ion channel clustering (GO:0072578)1.91542073
159retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)1.90399908
160membrane repolarization (GO:0086009)1.89007151
161epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)1.88601884
162positive regulation of glucose import (GO:0046326)1.87896649
163dicarboxylic acid biosynthetic process (GO:0043650)1.87664908
164positive regulation of excitatory postsynaptic membrane potential (GO:2000463)1.87615036
165intraciliary transport (GO:0042073)1.87573574

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.91965158
2GBX2_23144817_ChIP-Seq_PC3_Human2.86994511
3EZH2_22144423_ChIP-Seq_EOC_Human2.66644129
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47069772
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23978536
6PIAS1_25552417_ChIP-Seq_VCAP_Human2.15430493
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.01852607
8* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.00564176
9* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.95814712
10POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88898658
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87015163
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.84537358
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81386719
14SMAD4_21799915_ChIP-Seq_A2780_Human1.81330906
15EWS_26573619_Chip-Seq_HEK293_Human1.66419179
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64898976
17* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63606197
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.62447897
19BCAT_22108803_ChIP-Seq_LS180_Human1.61570489
20VDR_22108803_ChIP-Seq_LS180_Human1.59485580
21STAT3_23295773_ChIP-Seq_U87_Human1.58456619
22* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57995107
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57495202
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57076975
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56701967
26ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56413204
27P300_19829295_ChIP-Seq_ESCs_Human1.51980944
28NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46409252
29FUS_26573619_Chip-Seq_HEK293_Human1.45731959
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45708624
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44485484
32TAF15_26573619_Chip-Seq_HEK293_Human1.44095814
33* ARNT_22903824_ChIP-Seq_MCF-7_Human1.44050627
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43459734
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.42501849
36* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42400414
37* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42400414
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.40709420
39RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40482761
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40141586
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40141586
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40097862
43* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39788234
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.39402126
45ZNF274_21170338_ChIP-Seq_K562_Hela1.38955302
46AHR_22903824_ChIP-Seq_MCF-7_Human1.38638356
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38146767
48* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37084005
49* SOX2_21211035_ChIP-Seq_LN229_Gbm1.37012070
50AR_21572438_ChIP-Seq_LNCaP_Human1.36085149
51* TP53_16413492_ChIP-PET_HCT116_Human1.35102011
52DROSHA_22980978_ChIP-Seq_HELA_Human1.34433947
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33845392
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.32145752
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30460165
56* AR_25329375_ChIP-Seq_VCAP_Human1.30419488
57TCF4_23295773_ChIP-Seq_U87_Human1.30100695
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29020328
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28564786
60STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27394065
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27116715
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.26053674
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25506608
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25053052
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24673986
66TP53_18474530_ChIP-ChIP_U2OS_Human1.24471714
67JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23902903
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22968454
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21350100
70CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.21345061
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20757490
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.19799905
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.19511782
74EZH2_27304074_Chip-Seq_ESCs_Mouse1.19278662
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19177434
76* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17873052
77* AR_19668381_ChIP-Seq_PC3_Human1.17845590
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.17230355
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16999621
80LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16764300
81RNF2_27304074_Chip-Seq_NSC_Mouse1.15829627
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15388602
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15105092
84RUNX2_22187159_ChIP-Seq_PCA_Human1.14621242
85SOX9_26525672_Chip-Seq_HEART_Mouse1.14524829
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14217006
87CBP_20019798_ChIP-Seq_JUKART_Human1.14217006
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.14017251
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.13515590
90ER_23166858_ChIP-Seq_MCF-7_Human1.12419589
91TCF4_22108803_ChIP-Seq_LS180_Human1.12405032
92P53_22387025_ChIP-Seq_ESCs_Mouse1.12174132
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12096164
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11806073
95RXR_22108803_ChIP-Seq_LS180_Human1.10920850
96CJUN_26792858_Chip-Seq_BT549_Human1.09503995
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09192922
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09148546
99ESR1_20079471_ChIP-ChIP_T-47D_Human1.09114228
100* SMAD_19615063_ChIP-ChIP_OVARY_Human1.08985013
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07843809
102TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06872190
103CMYC_18555785_Chip-Seq_ESCs_Mouse1.06590556
104TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05843683
105* REST_21632747_ChIP-Seq_MESCs_Mouse1.05291162
106* FLI1_21867929_ChIP-Seq_TH2_Mouse1.05290843
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05259060
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.05160634
109* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04791378
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04753773
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04531050
112SMAD3_21741376_ChIP-Seq_HESCs_Human1.04518973
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.04507680
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04277957
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04277957
116CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04030266
117* FOXA2_19822575_ChIP-Seq_HepG2_Human1.03835733
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03619012
119WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03604533
120IGF1R_20145208_ChIP-Seq_DFB_Human1.02135151
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01662294
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00760646
123FLI1_27457419_Chip-Seq_LIVER_Mouse1.00631792
124TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99736763
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99687713
126EZH2_27294783_Chip-Seq_ESCs_Mouse0.98688932
127CLOCK_20551151_ChIP-Seq_293T_Human0.98673720

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo3.84047591
2MP0000566_synostosis2.43485242
3MP0003136_yellow_coat_color2.10525478
4MP0009384_cardiac_valve_regurgitation2.09067930
5MP0003880_abnormal_central_pattern2.08223115
6MP0004043_abnormal_pH_regulation2.03870580
7MP0003252_abnormal_bile_duct1.98617347
8MP0003283_abnormal_digestive_organ1.98326349
9MP0004859_abnormal_synaptic_plasticity1.94031113
10MP0001299_abnormal_eye_distance/1.92327608
11MP0010234_abnormal_vibrissa_follicle1.90382177
12MP0000383_abnormal_hair_follicle1.83061979
13MP0000569_abnormal_digit_pigmentation1.80479282
14MP0004270_analgesia1.72752428
15MP0005646_abnormal_pituitary_gland1.68025637
16MP0010386_abnormal_urinary_bladder1.66748201
17MP0003183_abnormal_peptide_metabolism1.66500243
18MP0000537_abnormal_urethra_morphology1.65312252
19MP0002837_dystrophic_cardiac_calcinosis1.64231203
20MP0002877_abnormal_melanocyte_morpholog1.63750751
21MP0003690_abnormal_glial_cell1.60006182
22MP0009046_muscle_twitch1.59481669
23MP0003705_abnormal_hypodermis_morpholog1.58476201
24MP0002909_abnormal_adrenal_gland1.54707068
25MP0002009_preneoplasia1.50856639
26MP0004084_abnormal_cardiac_muscle1.49965044
27MP0002638_abnormal_pupillary_reflex1.49446991
28MP0003635_abnormal_synaptic_transmissio1.49331993
29MP0002139_abnormal_hepatobiliary_system1.49131058
30MP0005171_absent_coat_pigmentation1.48942901
31MP0004272_abnormal_basement_membrane1.46602305
32MP0003941_abnormal_skin_development1.44500102
33MP0008438_abnormal_cutaneous_collagen1.43271982
34MP0002254_reproductive_system_inflammat1.41346147
35MP0001177_atelectasis1.40184377
36MP0002896_abnormal_bone_mineralization1.38632189
37MP0005623_abnormal_meninges_morphology1.37958097
38MP0005248_abnormal_Harderian_gland1.35938484
39MP0003787_abnormal_imprinting1.35615436
40MP0001486_abnormal_startle_reflex1.34044208
41MP0006072_abnormal_retinal_apoptosis1.32573305
42MP0003045_fibrosis1.31784124
43MP0002938_white_spotting1.29522951
44MP0005365_abnormal_bile_salt1.28505592
45MP0004885_abnormal_endolymph1.27428719
46MP0005551_abnormal_eye_electrophysiolog1.23173829
47MP0002063_abnormal_learning/memory/cond1.22476337
48MP0002234_abnormal_pharynx_morphology1.17373514
49MP0003195_calcinosis1.13813979
50MP0002697_abnormal_eye_size1.13559973
51MP0005187_abnormal_penis_morphology1.13467214
52MP0010352_gastrointestinal_tract_polyps1.12293865
53MP0002168_other_aberrant_phenotype1.11718785
54MP0000579_abnormal_nail_morphology1.10946055
55MP0003868_abnormal_feces_composition1.09652754
56MP0002184_abnormal_innervation1.09255888
57MP0004145_abnormal_muscle_electrophysio1.08939320
58MP0000534_abnormal_ureter_morphology1.08832601
59MP0005409_darkened_coat_color1.07415170
60MP0005085_abnormal_gallbladder_physiolo1.06937678
61MP0004742_abnormal_vestibular_system1.06854138
62MP0005503_abnormal_tendon_morphology1.05760360
63MP0002108_abnormal_muscle_morphology1.05591660
64MP0008877_abnormal_DNA_methylation1.04734434
65MP0003122_maternal_imprinting1.04670896
66MP0001944_abnormal_pancreas_morphology1.03802323
67MP0005253_abnormal_eye_physiology1.03258257
68MP0000462_abnormal_digestive_system1.02730827
69MP0002064_seizures1.02599731
70MP0005360_urolithiasis1.02223660
71MP0002572_abnormal_emotion/affect_behav1.02213879
72MP0009745_abnormal_behavioral_response1.01605774
73MP0000955_abnormal_spinal_cord1.01295300
74MP0004233_abnormal_muscle_weight1.01204073
75MP0003890_abnormal_embryonic-extraembry1.00743768
76MP0002090_abnormal_vision1.00520867
77MP0003950_abnormal_plasma_membrane0.99754348
78MP0005275_abnormal_skin_tensile0.99688840
79MP0002557_abnormal_social/conspecific_i0.99581446
80MP0005379_endocrine/exocrine_gland_phen0.98732844
81MP0009053_abnormal_anal_canal0.98603201
82MP0008057_abnormal_DNA_replication0.97495453
83MP0003937_abnormal_limbs/digits/tail_de0.97278156
84MP0004924_abnormal_behavior0.96514682
85MP0005386_behavior/neurological_phenoty0.96514682
86MP0004036_abnormal_muscle_relaxation0.96468067
87MP0000647_abnormal_sebaceous_gland0.96105624
88MP0001984_abnormal_olfaction0.95129364
89MP0002928_abnormal_bile_duct0.94452987
90MP0004264_abnormal_extraembryonic_tissu0.94078504
91* MP0000013_abnormal_adipose_tissue0.93736652
92MP0001293_anophthalmia0.93730993
93* MP0000778_abnormal_nervous_system0.93721986
94MP0002734_abnormal_mechanical_nocicepti0.93236309
95MP0004215_abnormal_myocardial_fiber0.91484289
96MP0005367_renal/urinary_system_phenotyp0.91237017
97MP0000516_abnormal_urinary_system0.91237017
98MP0001286_abnormal_eye_development0.91174253
99MP0010329_abnormal_lipoprotein_level0.91088511
100MP0005220_abnormal_exocrine_pancreas0.90981070
101MP0002160_abnormal_reproductive_system0.90243880
102MP0000427_abnormal_hair_cycle0.88850895
103MP0004085_abnormal_heartbeat0.88796011
104MP0003935_abnormal_craniofacial_develop0.88711889
105MP0000762_abnormal_tongue_morphology0.88420868
106MP0002295_abnormal_pulmonary_circulatio0.88255005
107MP0002272_abnormal_nervous_system0.87526600
108MP0000631_abnormal_neuroendocrine_gland0.87316836
109MP0003755_abnormal_palate_morphology0.87212230
110MP0003633_abnormal_nervous_system0.85532111
111MP0003300_gastrointestinal_ulcer0.85360119
112MP0001501_abnormal_sleep_pattern0.85078029
113MP0004858_abnormal_nervous_system0.85061525
114MP0009703_decreased_birth_body0.84310754
115MP0006276_abnormal_autonomic_nervous0.83247032
116MP0002882_abnormal_neuron_morphology0.83178827
117MP0009697_abnormal_copulation0.83166412
118MP0010678_abnormal_skin_adnexa0.82790779
119MP0003634_abnormal_glial_cell0.81765511
120MP0002067_abnormal_sensory_capabilities0.80645331
121MP0005391_vision/eye_phenotype0.80380778
122MP0003137_abnormal_impulse_conducting0.79696962
123MP0002282_abnormal_trachea_morphology0.79445561
124MP0002078_abnormal_glucose_homeostasis0.79278752
125MP0003861_abnormal_nervous_system0.77983734
126MP0001661_extended_life_span0.77652496
127MP0002233_abnormal_nose_morphology0.77596595
128MP0003123_paternal_imprinting0.77592212
129MP0000428_abnormal_craniofacial_morphol0.77475008
130MP0003632_abnormal_nervous_system0.77428568
131MP0000538_abnormal_urinary_bladder0.77365714
132MP0003121_genomic_imprinting0.76836339
133MP0001502_abnormal_circadian_rhythm0.76770402
134* MP0002152_abnormal_brain_morphology0.76657839
135MP0003119_abnormal_digestive_system0.76500932
136MP0004484_altered_response_of0.76209167
137MP0003942_abnormal_urinary_system0.76025723
138MP0001485_abnormal_pinna_reflex0.75199169
139MP0003943_abnormal_hepatobiliary_system0.75105379
140MP0002693_abnormal_pancreas_physiology0.74999126
141MP0008569_lethality_at_weaning0.74755631
142MP0003385_abnormal_body_wall0.74197749
143MP0004130_abnormal_muscle_cell0.74061020
144MP0001440_abnormal_grooming_behavior0.73879689
145MP0000026_abnormal_inner_ear0.73129813
146MP0002735_abnormal_chemical_nociception0.71723732
147MP0003631_nervous_system_phenotype0.71318088
148MP0002092_abnormal_eye_morphology0.70505403

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)2.97216483
2Hypoglycemic seizures (HP:0002173)2.88242936
3Action tremor (HP:0002345)2.68837097
4Arterial tortuosity (HP:0005116)2.50033196
5Degeneration of the lateral corticospinal tracts (HP:0002314)2.46636371
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.46636371
7Hypoalphalipoproteinemia (HP:0003233)2.42929465
8Vascular tortuosity (HP:0004948)2.41929631
9Megalencephaly (HP:0001355)2.36615483
10Macroorchidism (HP:0000053)2.34672990
11Hyperglycemia (HP:0003074)2.34425148
12Insulin-resistant diabetes mellitus (HP:0000831)2.32463353
13Decreased lacrimation (HP:0000633)2.31003598
14Hypoglycemic coma (HP:0001325)2.30531673
15Thyroid carcinoma (HP:0002890)2.29079587
16Symptomatic seizures (HP:0011145)2.28675453
17Abnormality of the corticospinal tract (HP:0002492)2.25622697
18Ketoacidosis (HP:0001993)2.25329618
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.23543660
20Progressive cerebellar ataxia (HP:0002073)2.21866150
21Hypoplastic labia majora (HP:0000059)2.21784537
22Abnormal respiratory motile cilium physiology (HP:0012261)2.21501792
23Chronic hepatic failure (HP:0100626)2.20488311
24Hepatoblastoma (HP:0002884)2.17624650
25Volvulus (HP:0002580)2.15587984
26Aplasia involving bones of the upper limbs (HP:0009823)2.15368988
27Aplasia of the phalanges of the hand (HP:0009802)2.15368988
28Aplasia involving bones of the extremities (HP:0009825)2.15368988
29Alacrima (HP:0000522)2.14064366
30Focal motor seizures (HP:0011153)2.14006434
31Abnormal ciliary motility (HP:0012262)2.13403052
32Right ventricular cardiomyopathy (HP:0011663)2.07298285
33Tubulointerstitial nephritis (HP:0001970)2.06552046
34Dysdiadochokinesis (HP:0002075)2.06003644
35Dialeptic seizures (HP:0011146)2.05570124
36Impaired vibration sensation in the lower limbs (HP:0002166)2.04585132
37Intention tremor (HP:0002080)2.03686819
38Papillary thyroid carcinoma (HP:0002895)2.03062094
39Excessive salivation (HP:0003781)2.02887712
40Drooling (HP:0002307)2.02887712
41Retinal atrophy (HP:0001105)2.02340998
42Overgrowth (HP:0001548)1.99247235
43Absent/shortened dynein arms (HP:0200106)1.97891716
44Dynein arm defect of respiratory motile cilia (HP:0012255)1.97891716
45Abnormality of the labia majora (HP:0012881)1.97150593
46Atonic seizures (HP:0010819)1.95292412
47Subacute progressive viral hepatitis (HP:0006572)1.94241111
48Abnormality of the intrinsic pathway (HP:0010989)1.93326316
49Epileptic encephalopathy (HP:0200134)1.91101510
50Abnormality of the ischium (HP:0003174)1.90370851
51Genital tract atresia (HP:0001827)1.90366675
52Thickened helices (HP:0000391)1.89502456
53Bell-shaped thorax (HP:0001591)1.88828237
54Gastrointestinal atresia (HP:0002589)1.88383950
55Labial hypoplasia (HP:0000066)1.87735543
56Abnormal pancreas size (HP:0012094)1.87623019
57Broad-based gait (HP:0002136)1.87596232
58Abnormality of the nasal septum (HP:0000419)1.86545878
59Preaxial foot polydactyly (HP:0001841)1.80554695
60EEG with generalized epileptiform discharges (HP:0011198)1.79677609
61Epileptiform EEG discharges (HP:0011182)1.79452061
62Limited hip movement (HP:0008800)1.78211887
63Abnormal auditory evoked potentials (HP:0006958)1.77273317
64Gaze-evoked nystagmus (HP:0000640)1.76860675
65Esophageal atresia (HP:0002032)1.76754886
66Vaginal atresia (HP:0000148)1.76306521
67Fair hair (HP:0002286)1.75377739
68Midline defect of the nose (HP:0004122)1.74102103
69Hypsarrhythmia (HP:0002521)1.72760613
70Hypolipoproteinemia (HP:0010981)1.72197031
71Bundle branch block (HP:0011710)1.70771600
72Syncope (HP:0001279)1.70724309
73Aplasia/Hypoplasia of the tibia (HP:0005772)1.70610682
74Truncal ataxia (HP:0002078)1.70533044
75Hypoplastic ischia (HP:0003175)1.70048803
76Focal seizures (HP:0007359)1.69087706
77Horizontal nystagmus (HP:0000666)1.68059384
78Hemiparesis (HP:0001269)1.67381086
79Tetraplegia (HP:0002445)1.66278760
80Bifid scrotum (HP:0000048)1.66178695
81Enlarged kidneys (HP:0000105)1.65071667
82True hermaphroditism (HP:0010459)1.64986702
83Postural tremor (HP:0002174)1.63355249
84Absence seizures (HP:0002121)1.63123145
85Neonatal short-limb short stature (HP:0008921)1.62172520
86Hyperventilation (HP:0002883)1.61598408
87Abnormality of the lower motor neuron (HP:0002366)1.61217921
88Fibular hypoplasia (HP:0003038)1.60653347
89Termporal pattern (HP:0011008)1.60564100
90Insidious onset (HP:0003587)1.60564100
91Bifid tongue (HP:0010297)1.60321816
92Broad ribs (HP:0000885)1.60042834
93Blue irides (HP:0000635)1.60042431
94Turricephaly (HP:0000262)1.58047265
95Bronchomalacia (HP:0002780)1.58002907
96Potter facies (HP:0002009)1.57400775
97Facial shape deformation (HP:0011334)1.57400775
98Coronal craniosynostosis (HP:0004440)1.57302658
99Absent eyebrow (HP:0002223)1.56914561
100Myokymia (HP:0002411)1.56596405
101Hemiplegia (HP:0002301)1.56466632
102Epidermoid cyst (HP:0200040)1.55831916
103Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.55218644
104Aplasia/Hypoplasia of the sternum (HP:0006714)1.55110883
105Subcapsular cataract (HP:0000523)1.55056461
106Tracheomalacia (HP:0002779)1.55034044
107Vertebral arch anomaly (HP:0008438)1.54491938
108Intestinal atresia (HP:0011100)1.54432102
109Cutaneous finger syndactyly (HP:0010554)1.54181344
110Febrile seizures (HP:0002373)1.53952017
111Aortic aneurysm (HP:0004942)1.52968559
112Renal hypoplasia (HP:0000089)1.52750508
113Urethral obstruction (HP:0000796)1.52532603
114Rhinitis (HP:0012384)1.52518082
115Impaired smooth pursuit (HP:0007772)1.52176023
116Short tibia (HP:0005736)1.52085156
117Intrahepatic cholestasis (HP:0001406)1.51921367
118Dysmetria (HP:0001310)1.51901450
119Dysmetric saccades (HP:0000641)1.51698605
120Pheochromocytoma (HP:0002666)1.51617770
121Cerebral aneurysm (HP:0004944)1.51439107
122Central scotoma (HP:0000603)1.51344871
123Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.50610359
124Abnormality of ocular smooth pursuit (HP:0000617)1.50021837
125Ankyloglossia (HP:0010296)1.49651487
126Gait imbalance (HP:0002141)1.49250035
127Hypoplastic female external genitalia (HP:0012815)1.48932001
128Poor coordination (HP:0002370)1.48525409
129Scanning speech (HP:0002168)1.48484750
130Hematochezia (HP:0002573)1.48153620
131Skin nodule (HP:0200036)1.47273201
132Relative macrocephaly (HP:0004482)1.46488557
133Abnormal biliary tract morphology (HP:0012440)1.46059937
134Chronic bronchitis (HP:0004469)1.45389955
135Vertebral clefting (HP:0008428)1.44321959
136Chorioretinal atrophy (HP:0000533)1.44080767
137Resting tremor (HP:0002322)1.43708790
138Pulmonic stenosis (HP:0001642)1.43667791
139Cutaneous syndactyly (HP:0012725)1.43427113
140Genetic anticipation (HP:0003743)1.43026612
141Prolonged partial thromboplastin time (HP:0003645)1.42894139
142Abnormality of the pubic bones (HP:0003172)1.42744004
143Shallow orbits (HP:0000586)1.42598447
144Medial flaring of the eyebrow (HP:0010747)1.42392407
145Acanthocytosis (HP:0001927)1.42201257
146Congenital primary aphakia (HP:0007707)1.41790743
147Buphthalmos (HP:0000557)1.41695296
148Abnormality of the renal medulla (HP:0100957)1.41327535
149Abnormality of the phalanges of the 2nd finger (HP:0009541)1.41062742
150Tubulointerstitial abnormality (HP:0001969)1.40774910
151Generalized tonic-clonic seizures (HP:0002069)1.39792524
152Increased circulating renin level (HP:0000848)1.39762242
153Optic nerve hypoplasia (HP:0000609)1.38419090
154Heterotopia (HP:0002282)1.37456063
155Anophthalmia (HP:0000528)1.36417145
156Aqueductal stenosis (HP:0002410)1.35141932

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.50700123
2INSRR2.87227004
3LATS12.81309133
4MAP3K42.18490151
5PRKD32.15572493
6NTRK32.04894798
7LMTK22.04115847
8MAP3K21.98633506
9FGFR21.90253479
10TNIK1.87971434
11AKT31.83630441
12PDK31.76401900
13PDK41.76401900
14MAP3K121.74779973
15PDK21.73720421
16PINK11.65936040
17SGK21.60357739
18SIK11.57563163
19WNK31.54785018
20FER1.52256173
21EPHA41.50895184
22BRD41.49758251
23MAPK151.48286063
24PDGFRA1.45531747
25CAMK1G1.41600551
26BRSK21.34716352
27SGK31.34348935
28CASK1.33900976
29NUAK11.30815466
30SGK4941.30742962
31SGK2231.30742962
32BMPR1B1.30201423
33ERBB31.29803260
34PNCK1.25881306
35LATS21.25839245
36CAMK1D1.25208494
37DDR21.24718013
38CAMKK21.21760616
39NTRK11.20829378
40NTRK21.18481378
41WNK11.16866653
42STK391.16711598
43OBSCN1.11990503
44NEK61.11697305
45PLK21.10797380
46CSNK1G11.10088583
47RIPK11.09457722
48PAK31.09160049
49WNK41.08720855
50STK38L1.08619703
51CSNK1G21.07271931
52DMPK1.07236816
53MET1.04602853
54CAMKK10.97111072
55WEE10.95445053
56ACVR1B0.95374109
57MAP3K90.94770307
58MARK10.93119100
59MKNK20.91957951
60PIK3CA0.91728659
61SCYL20.90957618
62CSNK1A1L0.89884801
63ERBB40.89459397
64FGFR10.88606111
65STK30.88123237
66PRKCE0.85140191
67BCR0.83892767
68MINK10.83453227
69PBK0.82996920
70PASK0.81268892
71CDC42BPA0.80292558
72SGK10.78068866
73PRKAA10.77266280
74KSR10.75968151
75EPHA30.75933631
76TRIB30.75534379
77CSNK1G30.75130560
78OXSR10.74390182
79NEK90.74049319
80MELK0.73710932
81RET0.73650014
82MAP2K40.72869618
83UHMK10.72035055
84MAP2K70.71148050
85PAK60.70055243
86PDGFRB0.70017466
87PLK40.69713769
88TYRO30.68209472
89PTK20.65268133
90PRKCG0.65107636
91PRKCH0.65071829
92STK380.63747824
93FGFR30.62921117
94MYLK0.62888462
95PLK30.62609508
96PHKG20.61844839
97PHKG10.61844839
98ZAK0.61732322
99MST1R0.60773284
100NLK0.60773038
101TRIM280.60699324
102CDK50.60322477
103EPHB20.58505514
104NEK10.57983268
105ROCK10.56053196
106TGFBR20.55719684
107EPHA20.55140011
108GSK3A0.54999855
109RPS6KA30.54940110
110RPS6KB10.53938018
111CAMK2B0.53594761
112ERBB20.53584504
113TRPM70.53296673
114CCNB10.52683113
115DAPK20.52469000
116MKNK10.51722960
117PRKAA20.51117926
118CAMK2D0.50618004
119CAMK2A0.50247545
120MAPK130.50156882
121PDK10.49725489
122EIF2AK30.48632024
123STK240.47695988
124IGF1R0.46332736
125CSNK1E0.46303890
126PDPK10.46079652
127CDK30.45197591
128ROCK20.44815691
129MAPK100.44140784
130PRKG10.41413118
131HIPK20.41280333

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.92658929
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.34318180
3Sulfur metabolism_Homo sapiens_hsa009201.95762094
4Insulin secretion_Homo sapiens_hsa049111.93253943
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.81907487
6Nicotine addiction_Homo sapiens_hsa050331.66158887
7GABAergic synapse_Homo sapiens_hsa047271.58496830
8Fatty acid biosynthesis_Homo sapiens_hsa000611.52515525
9Type II diabetes mellitus_Homo sapiens_hsa049301.48255158
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45130867
11Amphetamine addiction_Homo sapiens_hsa050311.41354423
12Long-term potentiation_Homo sapiens_hsa047201.39767101
13Circadian entrainment_Homo sapiens_hsa047131.38645616
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37913961
15Butanoate metabolism_Homo sapiens_hsa006501.36684450
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34257706
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32113166
18Propanoate metabolism_Homo sapiens_hsa006401.29774298
19Glutamatergic synapse_Homo sapiens_hsa047241.28765470
20Fatty acid metabolism_Homo sapiens_hsa012121.26881484
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26154833
22Renin secretion_Homo sapiens_hsa049241.23521964
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20862356
24Fatty acid degradation_Homo sapiens_hsa000711.17656012
25Glucagon signaling pathway_Homo sapiens_hsa049221.16441554
26Salivary secretion_Homo sapiens_hsa049701.16386729
27Bile secretion_Homo sapiens_hsa049761.14841264
28Thyroid hormone synthesis_Homo sapiens_hsa049181.13967159
29Dopaminergic synapse_Homo sapiens_hsa047281.12786731
30Steroid biosynthesis_Homo sapiens_hsa001001.11410888
31Dorso-ventral axis formation_Homo sapiens_hsa043201.10064292
32Taste transduction_Homo sapiens_hsa047421.09877894
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09856280
34Gastric acid secretion_Homo sapiens_hsa049711.09438145
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09417929
36Morphine addiction_Homo sapiens_hsa050321.07956586
37Basal cell carcinoma_Homo sapiens_hsa052171.07919915
38Hedgehog signaling pathway_Homo sapiens_hsa043401.05311172
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05238174
40Circadian rhythm_Homo sapiens_hsa047101.05055580
41Cocaine addiction_Homo sapiens_hsa050301.04634031
42Synaptic vesicle cycle_Homo sapiens_hsa047211.00095391
43PPAR signaling pathway_Homo sapiens_hsa033200.99859497
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99359154
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99081911
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98787837
47Arginine biosynthesis_Homo sapiens_hsa002200.98730155
48Long-term depression_Homo sapiens_hsa047300.96821618
49Cholinergic synapse_Homo sapiens_hsa047250.96385188
50Estrogen signaling pathway_Homo sapiens_hsa049150.95443522
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94065742
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92734058
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91426701
54Vitamin B6 metabolism_Homo sapiens_hsa007500.91321170
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90624833
56Oocyte meiosis_Homo sapiens_hsa041140.88888472
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86152854
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85804428
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85203342
60Adherens junction_Homo sapiens_hsa045200.82572658
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81396656
62Pancreatic secretion_Homo sapiens_hsa049720.80694023
63Mineral absorption_Homo sapiens_hsa049780.80565999
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79595338
65Histidine metabolism_Homo sapiens_hsa003400.78786050
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78591404
67Tryptophan metabolism_Homo sapiens_hsa003800.76828039
68Insulin resistance_Homo sapiens_hsa049310.76433411
69Olfactory transduction_Homo sapiens_hsa047400.76259284
70Melanogenesis_Homo sapiens_hsa049160.75802828
71cAMP signaling pathway_Homo sapiens_hsa040240.75453830
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73768941
73Tight junction_Homo sapiens_hsa045300.73744536
74Dilated cardiomyopathy_Homo sapiens_hsa054140.70856200
75Serotonergic synapse_Homo sapiens_hsa047260.70587651
76Hippo signaling pathway_Homo sapiens_hsa043900.69858971
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69222284
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68712990
79mTOR signaling pathway_Homo sapiens_hsa041500.66722019
80Gap junction_Homo sapiens_hsa045400.66408644
81Protein digestion and absorption_Homo sapiens_hsa049740.65982755
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.65736116
83Alcoholism_Homo sapiens_hsa050340.65486377
84Starch and sucrose metabolism_Homo sapiens_hsa005000.64984436
85Choline metabolism in cancer_Homo sapiens_hsa052310.64846796
86AMPK signaling pathway_Homo sapiens_hsa041520.63702471
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62931460
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.62679042
89Oxytocin signaling pathway_Homo sapiens_hsa049210.62649667
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62269206
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61923910
92Calcium signaling pathway_Homo sapiens_hsa040200.61753384
93GnRH signaling pathway_Homo sapiens_hsa049120.61253064
94Inositol phosphate metabolism_Homo sapiens_hsa005620.60770365
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60330688
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60104862
97ECM-receptor interaction_Homo sapiens_hsa045120.59861891
98Axon guidance_Homo sapiens_hsa043600.57870514
99Endometrial cancer_Homo sapiens_hsa052130.57868716
100Pyruvate metabolism_Homo sapiens_hsa006200.55477027
101Glioma_Homo sapiens_hsa052140.55352702
102Lysine degradation_Homo sapiens_hsa003100.55171012
103Insulin signaling pathway_Homo sapiens_hsa049100.54079032
104Vibrio cholerae infection_Homo sapiens_hsa051100.54006822
105Phototransduction_Homo sapiens_hsa047440.53141744
106beta-Alanine metabolism_Homo sapiens_hsa004100.52727179
107Fat digestion and absorption_Homo sapiens_hsa049750.51874625
108Proteoglycans in cancer_Homo sapiens_hsa052050.51676427
109* Focal adhesion_Homo sapiens_hsa045100.51382958
110TGF-beta signaling pathway_Homo sapiens_hsa043500.49884315
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49409449
112Selenocompound metabolism_Homo sapiens_hsa004500.49024238
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48540953
114Prion diseases_Homo sapiens_hsa050200.48280155
115Wnt signaling pathway_Homo sapiens_hsa043100.48117014
116Glycerolipid metabolism_Homo sapiens_hsa005610.47826504
117ErbB signaling pathway_Homo sapiens_hsa040120.47344873
118ABC transporters_Homo sapiens_hsa020100.47156257

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