ARHGAP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)6.21210244
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.90602721
3regulation of platelet aggregation (GO:0090330)5.59539454
4negative regulation of homotypic cell-cell adhesion (GO:0034111)5.42429366
5regulation of integrin-mediated signaling pathway (GO:2001044)4.92341898
6platelet aggregation (GO:0070527)4.82688029
7neutrophil activation involved in immune response (GO:0002283)4.67734288
8regulation of platelet activation (GO:0010543)4.61611872
9negative regulation of erythrocyte differentiation (GO:0045647)4.57990677
10production of molecular mediator involved in inflammatory response (GO:0002532)4.57358872
11definitive hemopoiesis (GO:0060216)4.55245593
12adenosine receptor signaling pathway (GO:0001973)4.52682714
13negative regulation of norepinephrine secretion (GO:0010700)4.51133908
14negative regulation of protein localization to cell surface (GO:2000009)4.43847148
15defense response to protozoan (GO:0042832)4.37643272
16response to interferon-beta (GO:0035456)4.36712762
17negative regulation of platelet activation (GO:0010544)4.34021248
18regulation of cAMP-dependent protein kinase activity (GO:2000479)4.03852071
19cellular response to interferon-beta (GO:0035458)4.00391614
20response to protozoan (GO:0001562)3.96799064
21nerve growth factor signaling pathway (GO:0038180)3.95430841
22positive regulation of mast cell activation involved in immune response (GO:0033008)3.94981045
23positive regulation of mast cell degranulation (GO:0043306)3.94981045
24iron ion import (GO:0097286)3.94654872
25platelet formation (GO:0030220)3.90268918
26regulation of integrin activation (GO:0033623)3.87608642
27positive regulation of gamma-delta T cell activation (GO:0046645)3.87247684
28mast cell activation (GO:0045576)3.86417671
29blood coagulation, intrinsic pathway (GO:0007597)3.77258585
30regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.76017915
31regulation of early endosome to late endosome transport (GO:2000641)3.70259370
32response to peptidoglycan (GO:0032494)3.69905523
33negative regulation of potassium ion transmembrane transport (GO:1901380)3.69028659
34relaxation of smooth muscle (GO:0044557)3.68022696
35superoxide anion generation (GO:0042554)3.66357291
36respiratory burst (GO:0045730)3.65467400
37relaxation of muscle (GO:0090075)3.62664053
38regulation of mast cell degranulation (GO:0043304)3.57629602
39positive regulation of mast cell activation (GO:0033005)3.57579785
40import into cell (GO:0098657)3.56448626
41modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.55761235
42modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.55761235
43positive regulation by organism of defense response of other organism involved in symbiotic interact3.55761235
44modulation by symbiont of host immune response (GO:0052553)3.55761235
45positive regulation by symbiont of host defense response (GO:0052509)3.55761235
46modulation by symbiont of host defense response (GO:0052031)3.55761235
47activation of protein kinase A activity (GO:0034199)3.53950227
48platelet degranulation (GO:0002576)3.53209654
49positive regulation of cellular amide metabolic process (GO:0034250)3.52636407
50positive regulation of natural killer cell differentiation (GO:0032825)3.51072743
51positive regulation of endothelial cell differentiation (GO:0045603)3.51054472
52cellular response to zinc ion (GO:0071294)3.49129789
53response to interferon-alpha (GO:0035455)3.49031644
54regulation of skeletal muscle contraction (GO:0014819)3.44352246
55response to type I interferon (GO:0034340)3.43748313
56type I interferon signaling pathway (GO:0060337)3.43100155
57cellular response to type I interferon (GO:0071357)3.43100155
58negative regulation of neural precursor cell proliferation (GO:2000178)3.41212900
59linoleic acid metabolic process (GO:0043651)3.40761559
60regulation of homotypic cell-cell adhesion (GO:0034110)3.39767862
61platelet dense granule organization (GO:0060155)3.39232840
62neutrophil activation (GO:0042119)3.38143669
63myeloid dendritic cell activation (GO:0001773)3.35835175
64angiogenesis involved in wound healing (GO:0060055)3.35833461
65regulation of mast cell activation (GO:0033003)3.32656137
66regulation of lipoprotein metabolic process (GO:0050746)3.26588196
67regulation of activation of Janus kinase activity (GO:0010533)3.26277640
68positive regulation of steroid hormone secretion (GO:2000833)3.25017156
69positive regulation of B cell differentiation (GO:0045579)3.24122687
70granulocyte activation (GO:0036230)3.23454930
71T-helper 1 type immune response (GO:0042088)3.22767272
72negative regulation of muscle contraction (GO:0045932)3.22188237
73regulation of mast cell activation involved in immune response (GO:0033006)3.19064513
74G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.18847088
75negative regulation of neurotransmitter secretion (GO:0046929)3.18694142
76protein neddylation (GO:0045116)3.18222763
77positive regulation of receptor recycling (GO:0001921)3.17985359
78myeloid cell activation involved in immune response (GO:0002275)3.15995049
79response to thyroid hormone (GO:0097066)3.15947770
80regulation of Golgi to plasma membrane protein transport (GO:0042996)3.14520812
81negative regulation of viral genome replication (GO:0045071)3.14515396
82immunoglobulin mediated immune response (GO:0016064)3.13109747
83histamine transport (GO:0051608)3.12211767
84negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.11886360
85platelet activation (GO:0030168)3.10748867
86megakaryocyte development (GO:0035855)3.10312372
87negative regulation of neurotransmitter transport (GO:0051589)3.08927270
88regulation of clathrin-mediated endocytosis (GO:2000369)3.07323745
89regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.06787947
90positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.04430381
91lipoxygenase pathway (GO:0019372)3.03174789
92myeloid dendritic cell differentiation (GO:0043011)3.02478764
93positive regulation of cardiac muscle hypertrophy (GO:0010613)3.02249142
94positive regulation of muscle hypertrophy (GO:0014742)3.02249142
95positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.02065917
96positive regulation of granulocyte differentiation (GO:0030854)3.01749132
97regulation of inositol phosphate biosynthetic process (GO:0010919)3.01622062
98histamine secretion (GO:0001821)3.00481982
99skeletal muscle tissue regeneration (GO:0043403)2.99225297
100negative regulation of interleukin-17 production (GO:0032700)2.99077489
101positive regulation of antigen processing and presentation (GO:0002579)2.98783090
102cellular response to exogenous dsRNA (GO:0071360)2.97894163
103extracellular fibril organization (GO:0043206)2.97463239
104regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.97129064
105homotypic cell-cell adhesion (GO:0034109)2.95127391
106interferon-gamma-mediated signaling pathway (GO:0060333)2.94576304
107positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.94381792
108lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93409924
109regulation of erythrocyte differentiation (GO:0045646)2.91578901
110Rap protein signal transduction (GO:0032486)2.91213553
111negative regulation of heart contraction (GO:0045822)2.89072871
112positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.88209870
113actin-myosin filament sliding (GO:0033275)2.87509027
114muscle filament sliding (GO:0030049)2.87509027
115mast cell degranulation (GO:0043303)2.87326333
116mast cell activation involved in immune response (GO:0002279)2.87326333
117dopamine transport (GO:0015872)2.86242541
118response to host immune response (GO:0052572)2.85991232
119response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.85991232
120regulation of T-helper 1 cell differentiation (GO:0045625)2.83763467
121fibroblast migration (GO:0010761)2.83347326
122positive regulation of interferon-alpha production (GO:0032727)2.82900278
123phagocytosis, recognition (GO:0006910)2.82741787
124leukocyte degranulation (GO:0043299)2.81663961
125negative regulation of histone methylation (GO:0031061)2.81562909
126cellular response to epinephrine stimulus (GO:0071872)2.81390985
127macrophage activation involved in immune response (GO:0002281)2.80544839
128myeloid leukocyte activation (GO:0002274)2.77861303
129myeloid cell development (GO:0061515)2.77506305
130positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.76969588
131positive regulation of chemokine biosynthetic process (GO:0045080)2.76201043
132cellular response to thyroid hormone stimulus (GO:0097067)2.75731080
133gas transport (GO:0015669)2.74893085
134detection of other organism (GO:0098543)2.74517963
135negative regulation of myeloid cell apoptotic process (GO:0033033)2.74146403
136oxygen transport (GO:0015671)2.73949861
137response to muramyl dipeptide (GO:0032495)2.73839585
138eosinophil chemotaxis (GO:0048245)2.71569050
139interkinetic nuclear migration (GO:0022027)2.71507498
140CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.71450216
141positive regulation of interleukin-1 beta secretion (GO:0050718)2.71398688
142granulocyte differentiation (GO:0030851)2.70886565
143negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.70492340
144positive regulation of Rho protein signal transduction (GO:0035025)2.69474863
145mesodermal cell differentiation (GO:0048333)2.69199730
146phagocytosis, engulfment (GO:0006911)2.68521071
147regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.66987169
148regulation of antigen processing and presentation (GO:0002577)2.66553592
149lymphoid progenitor cell differentiation (GO:0002320)2.64783550
150triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.64265828
151polyamine biosynthetic process (GO:0006596)2.64072968
152ribosomal small subunit assembly (GO:0000028)2.63956860
153positive regulation of systemic arterial blood pressure (GO:0003084)2.63866056
154regulation of chemokine biosynthetic process (GO:0045073)2.63740866
155regulation of interferon-alpha production (GO:0032647)2.62342218
156negative regulation of nitric oxide biosynthetic process (GO:0045019)2.61875245
157hypotonic response (GO:0006971)2.61823935
158phospholipid scrambling (GO:0017121)2.61744812
159toxin transport (GO:1901998)2.60709682
160regulation of myeloid leukocyte mediated immunity (GO:0002886)2.60652567
161regulation of interleukin-17 production (GO:0032660)2.60111459
162regulation of B cell receptor signaling pathway (GO:0050855)2.59409721
163negative regulation of protein localization to plasma membrane (GO:1903077)2.58781713
164positive regulation of vasculogenesis (GO:2001214)2.58657935
165detection of molecule of bacterial origin (GO:0032490)2.58346219
166autophagic vacuole fusion (GO:0000046)2.58290955
167regulation of B cell differentiation (GO:0045577)2.58251167
168response to epinephrine (GO:0071871)2.57639883
169mature B cell differentiation (GO:0002335)2.56887051
170creatine metabolic process (GO:0006600)2.56843535
171regulation of transforming growth factor beta2 production (GO:0032909)2.56827544
172positive regulation of interleukin-12 production (GO:0032735)2.56368126
173fibril organization (GO:0097435)2.56244240
174regulation of hypersensitivity (GO:0002883)2.55656185
175positive regulation of p38MAPK cascade (GO:1900745)2.54299426
176hydrogen peroxide biosynthetic process (GO:0050665)2.54214954
177positive regulation of interleukin-17 production (GO:0032740)2.53919792
178positive regulation of lymphocyte migration (GO:2000403)2.53881167
179positive regulation of interleukin-10 production (GO:0032733)2.53584024
180regulation of natural killer cell differentiation (GO:0032823)2.52618594
181regulation of interferon-beta biosynthetic process (GO:0045357)2.51803088
182daunorubicin metabolic process (GO:0044597)2.51725117
183doxorubicin metabolic process (GO:0044598)2.51725117
184protoporphyrinogen IX metabolic process (GO:0046501)2.51502496
185purinergic nucleotide receptor signaling pathway (GO:0035590)2.50592396
186leukocyte migration involved in inflammatory response (GO:0002523)2.49095572
187cGMP-mediated signaling (GO:0019934)2.46423701
188positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.45953158
189negative regulation of catecholamine secretion (GO:0033604)2.45039408
190muscle cell fate commitment (GO:0042693)2.44917429
191sarcoplasmic reticulum calcium ion transport (GO:0070296)2.44351702
192beta-amyloid metabolic process (GO:0050435)2.42228506
193myofibril assembly (GO:0030239)2.41352566
194negative regulation of heart rate (GO:0010459)2.40198566

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.10665272
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.54222005
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.98703803
4GATA1_19941826_ChIP-Seq_K562_Human4.39045803
5* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.00531380
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.94673419
7SCL_19346495_ChIP-Seq_HPC-7_Human3.77996436
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.47125710
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.35829695
10* GATA2_19941826_ChIP-Seq_K562_Human3.33271383
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.01567035
12EZH2_22144423_ChIP-Seq_EOC_Human2.96324857
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.92343600
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88822398
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.81886944
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.79305411
17GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.79159153
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.73138569
19NCOR1_26117541_ChIP-Seq_K562_Human2.52584187
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.48200065
21* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.35592028
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27485195
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.23335156
24GATA1_22025678_ChIP-Seq_K562_Human2.20910535
25GBX2_23144817_ChIP-Seq_PC3_Human2.20175899
26* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.20121005
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.16009878
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13468995
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.10112726
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03789979
31STAT4_19710469_ChIP-ChIP_TH1__Mouse2.01673854
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00188948
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.98328951
34IGF1R_20145208_ChIP-Seq_DFB_Human1.97084549
35GATA1_22383799_ChIP-Seq_G1ME_Mouse1.92672055
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.84211388
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.82413311
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.73661412
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.72677911
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.69773467
41GATA1_19941827_ChIP-Seq_MEL86_Mouse1.68854543
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.68471572
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66116169
44TCF7_22412390_ChIP-Seq_EML_Mouse1.65648473
45TAF15_26573619_Chip-Seq_HEK293_Human1.65191847
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.61785558
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59675535
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59040737
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.55294029
50SPI1_23547873_ChIP-Seq_NB4_Human1.53413517
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52116351
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.51181371
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.50022253
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.48360259
55RUNX_20019798_ChIP-Seq_JUKART_Human1.45951642
56AR_21572438_ChIP-Seq_LNCaP_Human1.44477020
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44469387
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.44266588
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44202783
60CLOCK_20551151_ChIP-Seq_293T_Human1.40925225
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.40174333
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39789266
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38796898
64MYC_22102868_ChIP-Seq_BL_Human1.36761799
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33374318
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31661392
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31374306
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30740668
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30686386
70PU_27001747_Chip-Seq_BMDM_Mouse1.29438601
71* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.29172431
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26485653
73VDR_22108803_ChIP-Seq_LS180_Human1.26188325
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26018619
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.25742161
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.22509188
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.21620771
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17932463
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17786631
80VDR_24787735_ChIP-Seq_THP-1_Human1.15965444
81FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15700334
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15477215
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15138946
84AR_21909140_ChIP-Seq_LNCAP_Human1.14270157
85P300_19829295_ChIP-Seq_ESCs_Human1.13737740
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13538141
87SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11767299
88ESR1_20079471_ChIP-ChIP_T-47D_Human1.11655597
89NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10508713
90FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10125085
91STAT3_18555785_Chip-Seq_ESCs_Mouse1.09853905
92SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09535548
93* SPI1_23127762_ChIP-Seq_K562_Human1.09434206
94EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08122829
95SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07619472
96P53_22387025_ChIP-Seq_ESCs_Mouse1.07554909
97CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07185508
98FOXA1_25552417_ChIP-Seq_VCAP_Human1.07152111
99RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07042064
100NMYC_18555785_Chip-Seq_ESCs_Mouse1.06859532
101RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04482751
102ETS1_22383799_ChIP-Seq_G1ME_Mouse1.03710249
103* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03706636
104GATA1_19941827_ChIP-Seq_MEL_Mouse1.03146159
105SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02968181
106GATA4_21415370_ChIP-Seq_HL-1_Mouse1.02835879
107ZNF263_19887448_ChIP-Seq_K562_Human1.02304250
108CHD1_26751641_Chip-Seq_LNCaP_Human1.02292581
109PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02005521
110PU1_27457419_Chip-Seq_LIVER_Mouse1.01964160
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.01740352
112EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01469295
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01455150
114CMYC_18555785_Chip-Seq_ESCs_Mouse1.00906472
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00289683
116RUNX1_22412390_ChIP-Seq_EML_Mouse1.00218078
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00128336
118CRX_20693478_ChIP-Seq_RETINA_Mouse1.00091706
119TBX20_22328084_ChIP-Seq_HEART_Mouse1.00017018
120TBX20_22080862_ChIP-Seq_HEART_Mouse1.00017018
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99321529
122LXR_22158963_ChIP-Seq_LIVER_Mouse0.97812290
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97780941
124OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97369823
125GATA3_26560356_Chip-Seq_TH2_Human0.96720903
126PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96274660
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.95985221
128TAL1_26923725_Chip-Seq_HPCs_Mouse0.95974929
129NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95517444
130NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95517444
131GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95442140
132VDR_24763502_ChIP-Seq_THP-1_Human0.95003393
133NANOG_18555785_Chip-Seq_ESCs_Mouse0.94452822
134TP53_18474530_ChIP-ChIP_U2OS_Human0.93964118
135SMAD1_18555785_Chip-Seq_ESCs_Mouse0.93303104
136TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93298219
137ELK4_26923725_Chip-Seq_MESODERM_Mouse0.93183982
138CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93067232
139CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92174662
140ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91684327
141SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91676745
142OCT4_18555785_Chip-Seq_ESCs_Mouse0.91550797
143PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.91506395
144NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91388641
145KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90882187
146MYB_26560356_Chip-Seq_TH2_Human0.90341557
147TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90340415
148P300_18555785_Chip-Seq_ESCs_Mouse0.89861113
149KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89722801
150GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89646783
151* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88990439
152LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88147464
153BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88072297
154ER_23166858_ChIP-Seq_MCF-7_Human0.87536366
155ZFX_18555785_Chip-Seq_ESCs_Mouse0.87412062
156CTCF_18555785_Chip-Seq_ESCs_Mouse0.85864324
157TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84998875
158* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.84622904
159SOX2_18555785_Chip-Seq_ESCs_Mouse0.84583711
160FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84536905
161WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84128238
162EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83490534
163KDM2B_26808549_Chip-Seq_DND41_Human0.82359396
164SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81575116

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH5.06788952
2MP0004084_abnormal_cardiac_muscle4.29920350
3MP0001835_abnormal_antigen_presentation4.14667549
4MP0004036_abnormal_muscle_relaxation4.01569158
5MP0002148_abnormal_hypersensitivity_rea3.70985101
6MP0004145_abnormal_muscle_electrophysio3.58448562
7MP0009785_altered_susceptibility_to3.36301451
8MP0003724_increased_susceptibility_to3.05897001
9MP0002419_abnormal_innate_immunity2.82539303
10MP0005464_abnormal_platelet_physiology2.79670636
11MP0005025_abnormal_response_to2.71380293
12MP0003436_decreased_susceptibility_to2.70161870
13MP0005000_abnormal_immune_tolerance2.65892804
14MP0003195_calcinosis2.54648462
15MP0005671_abnormal_response_to2.54093814
16MP0005174_abnormal_tail_pigmentation2.53974680
17MP0008775_abnormal_heart_ventricle2.48121213
18MP0004510_myositis2.36192954
19MP0005387_immune_system_phenotype2.35299744
20MP0001790_abnormal_immune_system2.35299744
21MP0002452_abnormal_antigen_presenting2.24833127
22MP0006082_CNS_inflammation2.24296805
23MP0000685_abnormal_immune_system2.21823465
24MP0003566_abnormal_cell_adhesion2.19836647
25MP0002723_abnormal_immune_serum2.17829694
26MP0001800_abnormal_humoral_immune2.07543002
27MP0005451_abnormal_body_composition2.06712461
28MP0003303_peritoneal_inflammation2.06024332
29MP0003705_abnormal_hypodermis_morpholog2.05134398
30MP0001819_abnormal_immune_cell1.96845514
31MP0002420_abnormal_adaptive_immunity1.94659984
32MP0001853_heart_inflammation1.94048762
33MP0009764_decreased_sensitivity_to1.91438258
34MP0000015_abnormal_ear_pigmentation1.85677786
35MP0004130_abnormal_muscle_cell1.83606486
36MP0005670_abnormal_white_adipose1.81838695
37MP0001188_hyperpigmentation1.75993668
38MP0000230_abnormal_systemic_arterial1.75920649
39MP0002006_tumorigenesis1.74931792
40MP0001545_abnormal_hematopoietic_system1.74077381
41MP0005397_hematopoietic_system_phenotyp1.74077381
42MP0005666_abnormal_adipose_tissue1.72527891
43MP0006138_congestive_heart_failure1.68167976
44MP0005310_abnormal_salivary_gland1.63603089
45MP0002166_altered_tumor_susceptibility1.60448406
46MP0005620_abnormal_muscle_contractility1.59771519
47MP0004808_abnormal_hematopoietic_stem1.58419166
48MP0001845_abnormal_inflammatory_respons1.52351663
49MP0002972_abnormal_cardiac_muscle1.51063443
50MP0003879_abnormal_hair_cell1.50872855
51MP0010155_abnormal_intestine_physiology1.49681623
52MP0003075_altered_response_to1.48911212
53MP0003300_gastrointestinal_ulcer1.48038808
54MP0005083_abnormal_biliary_tract1.47222781
55MP0004215_abnormal_myocardial_fiber1.45223520
56MP0004233_abnormal_muscle_weight1.45159102
57MP0001661_extended_life_span1.41813216
58MP0002398_abnormal_bone_marrow1.41085839
59MP0003045_fibrosis1.40748675
60MP0008469_abnormal_protein_level1.40712801
61MP0000465_gastrointestinal_hemorrhage1.40421562
62MP0002396_abnormal_hematopoietic_system1.38287038
63MP0000716_abnormal_immune_system1.38192995
64MP0005409_darkened_coat_color1.36057676
65MP0005385_cardiovascular_system_phenoty1.35676031
66MP0001544_abnormal_cardiovascular_syste1.35676031
67MP0003828_pulmonary_edema1.34127408
68MP0001533_abnormal_skeleton_physiology1.33251120
69MP0001879_abnormal_lymphatic_vessel1.32900632
70MP0000343_altered_response_to1.32567030
71MP0002405_respiratory_system_inflammati1.32048271
72MP0002095_abnormal_skin_pigmentation1.29909610
73MP0004087_abnormal_muscle_fiber1.29526859
74MP0002998_abnormal_bone_remodeling1.27133251
75MP0009697_abnormal_copulation1.25871656
76MP0000747_muscle_weakness1.25766858
77MP0005647_abnormal_sex_gland1.24223892
78MP0002009_preneoplasia1.22146250
79MP0000569_abnormal_digit_pigmentation1.19696167
80MP0003279_aneurysm1.19443083
81MP0005171_absent_coat_pigmentation1.17022765
82MP0000749_muscle_degeneration1.15237772
83MP0005075_abnormal_melanosome_morpholog1.14935617
84MP0000689_abnormal_spleen_morphology1.14469694
85MP0004947_skin_inflammation1.14344890
86MP0005058_abnormal_lysosome_morphology1.14324156
87MP0005167_abnormal_blood-brain_barrier1.13000423
88MP0003646_muscle_fatigue1.12335364
89MP0005379_endocrine/exocrine_gland_phen1.12187077
90MP0002429_abnormal_blood_cell1.12038504
91MP0004147_increased_porphyrin_level1.11479714
92MP0010630_abnormal_cardiac_muscle1.11298937
93MP0001986_abnormal_taste_sensitivity1.11170553
94MP0003091_abnormal_cell_migration1.11149546
95MP0002132_abnormal_respiratory_system1.11055101
96MP0002837_dystrophic_cardiac_calcinosis1.10951634
97MP0003950_abnormal_plasma_membrane1.10811450
98MP0002128_abnormal_blood_circulation1.10474595
99MP0002106_abnormal_muscle_physiology1.10342902
100MP0005166_decreased_susceptibility_to1.08900643
101MP0005330_cardiomyopathy1.08742181
102MP0005275_abnormal_skin_tensile1.07981616
103MP0005646_abnormal_pituitary_gland1.07627026
104MP0005375_adipose_tissue_phenotype1.06854142
105MP0003656_abnormal_erythrocyte_physiolo1.05426401
106MP0000372_irregular_coat_pigmentation1.04496519
107MP0002332_abnormal_exercise_endurance1.03094115
108MP0010386_abnormal_urinary_bladder1.03005663
109MP0000767_abnormal_smooth_muscle1.01948492
110MP0004272_abnormal_basement_membrane1.01037358
111MP0000751_myopathy1.00406984
112MP0000759_abnormal_skeletal_muscle1.00225900
113MP0003690_abnormal_glial_cell0.99329128
114MP0002722_abnormal_immune_system0.99313764
115MP0003448_altered_tumor_morphology0.99268533
116MP0009278_abnormal_bone_marrow0.98484785
117MP0004484_altered_response_of0.98164666
118MP0006292_abnormal_olfactory_placode0.98103758
119MP0004782_abnormal_surfactant_physiolog0.97955806
120MP0009763_increased_sensitivity_to0.95586188
121MP0004883_abnormal_blood_vessel0.94758585
122MP0002269_muscular_atrophy0.92581128
123MP0008438_abnormal_cutaneous_collagen0.92426606
124MP0003866_abnormal_defecation0.90760056
125MP0002877_abnormal_melanocyte_morpholog0.89782682
126MP0004085_abnormal_heartbeat0.89125020
127MP0005164_abnormal_response_to0.89091356
128MP0000681_abnormal_thyroid_gland0.88919419
129MP0009765_abnormal_xenobiotic_induced0.88895594
130MP0002277_abnormal_respiratory_mucosa0.88867186
131MP0005369_muscle_phenotype0.88705245
132MP0004134_abnormal_chest_morphology0.88483700
133MP0005503_abnormal_tendon_morphology0.88347567
134MP0002933_joint_inflammation0.87860114
135MP0008260_abnormal_autophagy0.87090469
136MP0003172_abnormal_lysosome_physiology0.85711134
137MP0001958_emphysema0.85172078
138MP0000249_abnormal_blood_vessel0.82977288
139MP0004185_abnormal_adipocyte_glucose0.80687752
140MP0000858_altered_metastatic_potential0.80482310
141MP0004858_abnormal_nervous_system0.80170232
142MP0005535_abnormal_body_temperature0.77848250
143MP0005595_abnormal_vascular_smooth0.77765503
144MP0009333_abnormal_splenocyte_physiolog0.74510435
145MP0005390_skeleton_phenotype0.72669403
146MP0001851_eye_inflammation0.72090599
147MP0000920_abnormal_myelination0.71856274
148MP0009379_abnormal_foot_pigmentation0.70506768
149MP0003763_abnormal_thymus_physiology0.69666743
150MP0000266_abnormal_heart_morphology0.67985554
151MP0008961_abnormal_basal_metabolism0.67776772
152MP0001764_abnormal_homeostasis0.67522886
153MP0001664_abnormal_digestion0.67264444
154MP0005645_abnormal_hypothalamus_physiol0.67164084
155MP0005410_abnormal_fertilization0.66215005
156MP0003638_abnormal_response/metabolism_0.65995097
157MP0005187_abnormal_penis_morphology0.65306340
158MP0003183_abnormal_peptide_metabolism0.65027870
159MP0002108_abnormal_muscle_morphology0.64964808
160MP0003959_abnormal_lean_body0.64737040
161MP0001614_abnormal_blood_vessel0.64634657
162MP0002876_abnormal_thyroid_physiology0.64050886
163MP0005023_abnormal_wound_healing0.61421819
164MP0001663_abnormal_digestive_system0.61144322
165MP0002925_abnormal_cardiovascular_devel0.60476144
166MP0005076_abnormal_cell_differentiation0.59566210
167MP0002971_abnormal_brown_adipose0.59143655
168MP0009642_abnormal_blood_homeostasis0.58749013

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.75938155
2Recurrent bacterial skin infections (HP:0005406)5.37242332
3Prolonged bleeding time (HP:0003010)4.48026311
4Recurrent gram-negative bacterial infections (HP:0005420)4.46002377
5Eczematoid dermatitis (HP:0000976)4.33574334
6Aortic aneurysm (HP:0004942)4.24381805
7Acanthocytosis (HP:0001927)4.18874752
8Hyperthyroidism (HP:0000836)4.14264921
9Poikilocytosis (HP:0004447)4.12585754
10Abnormality of macrophages (HP:0004311)4.06046344
11Petechiae (HP:0000967)3.98616906
12Myositis (HP:0100614)3.69671369
13Mediastinal lymphadenopathy (HP:0100721)3.68655512
14Exercise-induced myalgia (HP:0003738)3.67963080
15Elevated erythrocyte sedimentation rate (HP:0003565)3.66422497
16Polycythemia (HP:0001901)3.52595389
17Hyperlipoproteinemia (HP:0010980)3.50120879
18Recurrent skin infections (HP:0001581)3.44768547
19Prostate neoplasm (HP:0100787)3.43681853
20Gingival bleeding (HP:0000225)3.38477747
21Purpura (HP:0000979)3.37927387
22Autoimmune thrombocytopenia (HP:0001973)3.35436045
23Vacuolated lymphocytes (HP:0001922)3.32221160
24Calf muscle hypertrophy (HP:0008981)3.31447304
25Patchy hypopigmentation of hair (HP:0011365)3.29197063
26Optic neuritis (HP:0100653)3.28640053
27Retrobulbar optic neuritis (HP:0100654)3.28640053
28Vasculitis (HP:0002633)3.17181277
29Epistaxis (HP:0000421)3.16996583
30Muscle hypertrophy of the lower extremities (HP:0008968)3.16923536
31Orchitis (HP:0100796)3.16558188
32Increased IgM level (HP:0003496)3.13007329
33Truncus arteriosus (HP:0001660)3.11939367
34Recurrent fungal infections (HP:0002841)3.05473263
35Increased neuronal autofluorescent lipopigment (HP:0002074)2.97916616
36White forelock (HP:0002211)2.97207632
37Obstructive lung disease (HP:0006536)2.96590806
38Chronic obstructive pulmonary disease (HP:0006510)2.96590806
39Nemaline bodies (HP:0003798)2.95806354
40Muscle fiber inclusion bodies (HP:0100299)2.93996536
41Type 1 muscle fiber predominance (HP:0003803)2.93523119
42Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.90444536
43Menorrhagia (HP:0000132)2.83476781
44Cellulitis (HP:0100658)2.79579185
45Gingivitis (HP:0000230)2.74783722
46Meningitis (HP:0001287)2.72810833
47Chronic mucocutaneous candidiasis (HP:0002728)2.72586972
48Recurrent cutaneous fungal infections (HP:0011370)2.72586972
49Hypothermia (HP:0002045)2.72583654
50Increased cerebral lipofuscin (HP:0011813)2.70748276
51Recurrent viral infections (HP:0004429)2.70218132
52Thrombocytosis (HP:0001894)2.65637908
53Abnormality of the heme biosynthetic pathway (HP:0010472)2.65239144
54Conjunctival telangiectasia (HP:0000524)2.63972533
55IgM deficiency (HP:0002850)2.63724400
56Basal ganglia calcification (HP:0002135)2.63481875
57Gastrointestinal stroma tumor (HP:0100723)2.60071082
58Abnormality of the fingertips (HP:0001211)2.59099338
59Abnormal large intestine physiology (HP:0012700)2.58799988
60Abnormal gallbladder physiology (HP:0012438)2.56362656
61Cholecystitis (HP:0001082)2.56362656
62Abnormality of skeletal muscle fiber size (HP:0012084)2.56097724
63Abnormal platelet volume (HP:0011876)2.56046503
64Seborrheic dermatitis (HP:0001051)2.55434786
65Dysmetric saccades (HP:0000641)2.55197672
66Increased variability in muscle fiber diameter (HP:0003557)2.52420051
67Stomatitis (HP:0010280)2.51095171
68Bowel incontinence (HP:0002607)2.48187197
69Periodontitis (HP:0000704)2.47839893
70Abnormality of the prostate (HP:0008775)2.45688933
71Joint hemorrhage (HP:0005261)2.45535229
72Abnormal platelet function (HP:0011869)2.43073420
73Impaired platelet aggregation (HP:0003540)2.43073420
74Pulmonary artery stenosis (HP:0004415)2.40990236
75Abnormality of the common coagulation pathway (HP:0010990)2.40094750
76Urticaria (HP:0001025)2.39285632
77Hyporeflexia of lower limbs (HP:0002600)2.35295489
78Chronic otitis media (HP:0000389)2.33154908
79Recurrent pneumonia (HP:0006532)2.32471384
80Abnormality of the vasculature of the conjunctiva (HP:0008054)2.31828577
81Increased connective tissue (HP:0009025)2.29216876
82Reduced antithrombin III activity (HP:0001976)2.28272828
83Spontaneous hematomas (HP:0007420)2.27065197
84Ventricular fibrillation (HP:0001663)2.27018787
85Ankyloglossia (HP:0010296)2.26108300
86Centrally nucleated skeletal muscle fibers (HP:0003687)2.25115571
87Interstitial pulmonary disease (HP:0006530)2.24476843
88Abnormal pupillary function (HP:0007686)2.24394068
89Systemic lupus erythematosus (HP:0002725)2.23571717
90Abnormal delayed hypersensitivity skin test (HP:0002963)2.23229543
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22088483
92Atelectasis (HP:0100750)2.21025028
93Recurrent lower respiratory tract infections (HP:0002783)2.20841824
94Keratoconjunctivitis sicca (HP:0001097)2.20320761
95Abnormality of the calf musculature (HP:0001430)2.18709094
96Reticulocytosis (HP:0001923)2.18666930
97Myocardial infarction (HP:0001658)2.18405010
98Muscle fiber splitting (HP:0003555)2.18229781
99Tinnitus (HP:0000360)2.17547152
100Paralysis (HP:0003470)2.16276860
101Axonal loss (HP:0003447)2.14660400
102Papillary thyroid carcinoma (HP:0002895)2.13816017
103Upper limb muscle weakness (HP:0003484)2.13769350
104Chronic sinusitis (HP:0011109)2.11708788
105Agammaglobulinemia (HP:0004432)2.11036271
106Hypertensive crisis (HP:0100735)2.10158373
107Pulmonary infiltrates (HP:0002113)2.09857923
108Abnormality of the tricuspid valve (HP:0001702)2.09240216
109Testicular neoplasm (HP:0010788)2.09216860
110Increased mean platelet volume (HP:0011877)2.08809246
111Bulbar palsy (HP:0001283)2.08442917
112Arterial thrombosis (HP:0004420)2.07284908
113Abnormality of the left ventricular outflow tract (HP:0011103)2.07080280
114Subaortic stenosis (HP:0001682)2.07080280
115Venous insufficiency (HP:0005293)2.06767210
116Persistence of primary teeth (HP:0006335)2.05885508
117Venous abnormality (HP:0002624)2.03635377
118Albinism (HP:0001022)2.02184252
119Hypergammaglobulinemia (HP:0010702)1.99178599
120Bundle branch block (HP:0011710)1.99168753
121Glomerulonephritis (HP:0000099)1.99120029
122Encephalitis (HP:0002383)1.98553604
123Hemoptysis (HP:0002105)1.97971929
124Keratoconjunctivitis (HP:0001096)1.97088103
125Acute myeloid leukemia (HP:0004808)1.96241353
126Aortic dissection (HP:0002647)1.95347488
127Abnormality of lateral ventricle (HP:0030047)1.94409704
1283-Methylglutaconic aciduria (HP:0003535)1.94170145
129Myopathic facies (HP:0002058)1.93017940
130Neutropenia (HP:0001875)1.92258626
131Leukocytosis (HP:0001974)1.91757910
132Esophageal neoplasm (HP:0100751)1.90767087
133Neoplasm of head and neck (HP:0012288)1.90767087
134Syringomyelia (HP:0003396)1.90389001
135Spinal cord lesions (HP:0100561)1.90389001
136Nausea (HP:0002018)1.90300075
137Sudden death (HP:0001699)1.89953346
138Tetraparesis (HP:0002273)1.89579884
139Distal lower limb amyotrophy (HP:0008944)1.88684764
140Dyschromatopsia (HP:0007641)1.86273626
141Bruising susceptibility (HP:0000978)1.84880044
142Type I transferrin isoform profile (HP:0003642)1.83360630
143Papilledema (HP:0001085)1.82640991
144Osteomyelitis (HP:0002754)1.82320970
145Heterochromia iridis (HP:0001100)1.82059031
146Ileus (HP:0002595)1.81867841
147Hypokinesia (HP:0002375)1.80525722
148Amaurosis fugax (HP:0100576)1.80436680
149Poor head control (HP:0002421)1.79596707
150Microcytic anemia (HP:0001935)1.79391751
151Aortic valve stenosis (HP:0001650)1.78919658
152Abnormal protein glycosylation (HP:0012346)1.78578253
153Abnormal glycosylation (HP:0012345)1.78578253
154Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78578253
155Abnormal protein N-linked glycosylation (HP:0012347)1.78578253
156Relative macrocephaly (HP:0004482)1.78159097
157Abnormality of T cell physiology (HP:0011840)1.77868459
158Premature loss of primary teeth (HP:0006323)1.77453984
159Bone pain (HP:0002653)1.77225091
160Gastrointestinal dysmotility (HP:0002579)1.74586837
161Aneurysm (HP:0002617)1.73487105
162Myoglobinuria (HP:0002913)1.68973216
163Exercise-induced muscle cramps (HP:0003710)1.68221204
164Increased density of long bones (HP:0006392)1.66907597
165Gonadotropin excess (HP:0000837)1.66195796
166Spinal rigidity (HP:0003306)1.65889640
167Overgrowth (HP:0001548)1.59185220
168Thyroid carcinoma (HP:0002890)1.57993726
169Insidious onset (HP:0003587)1.57287050
170Termporal pattern (HP:0011008)1.57287050
171Asymmetric septal hypertrophy (HP:0001670)1.57276821
172Hypoparathyroidism (HP:0000829)1.55667868
173Lipoatrophy (HP:0100578)1.50157831
174Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.48721950
175Prolonged QT interval (HP:0001657)1.48466186
176Abnormality of oral frenula (HP:0000190)1.45690141
177Azoospermia (HP:0000027)1.42840975
178Distal lower limb muscle weakness (HP:0009053)1.42464671
179Male infertility (HP:0003251)1.42154465
180Colitis (HP:0002583)1.41991996
181Joint swelling (HP:0001386)1.40626751
182Cholelithiasis (HP:0001081)1.39074970
183Disproportionate tall stature (HP:0001519)1.38995318

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT33.96702336
2KIT3.41667497
3MAP3K143.37272332
4TXK3.27277162
5IRAK43.24884972
6EEF2K2.91863353
7MYLK2.86042773
8RIPK42.57537784
9IRAK32.53150058
10BMX2.42652354
11CAMK1D2.41782786
12MAP4K12.40133550
13CAMK1G2.34882126
14EIF2AK12.33864627
15TBK12.33090850
16IKBKE2.21361953
17MAP3K122.19227289
18MAP3K132.10105914
19BLK2.04475009
20MUSK2.03970774
21DMPK1.96761809
22IKBKB1.95080594
23KSR21.92183102
24TAOK31.90480971
25TEC1.85163083
26TNK21.82477555
27BTK1.82073292
28TIE11.79104512
29MATK1.77519858
30TRPM71.75194238
31JAK31.70073933
32ZAK1.69829795
33RAF11.67437515
34STK31.61512378
35MAPKAPK31.61296106
36PIM21.59006034
37PIK3CG1.57984231
38NME21.57872649
39ADRBK21.54160643
40LATS11.51170250
41PBK1.50699447
42SYK1.47753279
43FER1.45231668
44TNIK1.42354116
45ZAP701.36214913
46TYK21.35386681
47PKN21.34800680
48FES1.34570109
49TTN1.32483388
50MAPKAPK51.31644609
51CHUK1.28908060
52TRIB31.27200806
53ILK1.25907556
54NEK91.25623997
55LYN1.25623926
56TGFBR21.24710917
57PRKD31.23067771
58STK161.17175915
59PTK2B1.16206620
60PAK21.16013963
61MAPK121.11987588
62PIK3CA1.11616194
63RET1.10222339
64MAP3K21.07806850
65YES11.07227793
66BMPR21.04507809
67MARK21.01488969
68EIF2AK21.01376326
69JAK10.98546692
70CASK0.97738802
71VRK10.91984037
72MST40.91157535
73GRK70.88172198
74CSF1R0.87974557
75PIM10.87779570
76TAOK10.86746694
77LATS20.86625996
78STK240.86001237
79ABL20.85724266
80MAP2K10.85670529
81PDGFRA0.85609863
82HCK0.84922775
83PRKD20.84739814
84CDC42BPA0.84649410
85LCK0.83948456
86EPHA30.82796086
87PRKAA20.82406938
88CLK10.79995898
89PDPK10.79623181
90NEK60.79206691
91INSRR0.76794958
92DDR20.76696162
93MKNK10.76248414
94MAP2K30.73389581
95PAK10.73223327
96JAK20.71490456
97NUAK10.70881796
98MAP3K70.68930187
99CDK120.68651759
100SIK30.66702138
101DAPK30.64240555
102GRK50.64233848
103ICK0.64107289
104RPS6KA40.63420239
105MTOR0.63236925
106PRKD10.62242254
107PDGFRB0.61986690
108CSK0.61272355
109CCNB10.60039338
110STK40.59842222
111KSR10.59146459
112SIK10.58481422
113MAP3K10.57316537
114ERN10.56220092
115ERBB30.55184903
116PRKCQ0.54073729
117SGK20.53399936
118MKNK20.52469765
119GRK10.51925732
120PRKCE0.51273878
121PRKCD0.49259314
122PRKACG0.48703250
123RPS6KA60.47494197
124ABL10.46692945
125HIPK20.46435164
126PHKG10.45190116
127PHKG20.45190116
128MAP3K60.43652527
129WNK10.43233262
130PRKG20.42254121
131NLK0.41316875
132BRSK20.41282566
133CAMK10.40713866
134MAP3K50.40290314
135ROCK10.39664773
136CAMKK20.38798404
137TAOK20.36704597
138EGFR0.36703925
139IRAK10.35624819
140FGFR30.31156540
141RPS6KA50.30566544
142SGK30.30359595
143IRAK20.29927712
144MAPK150.29282056
145RPS6KC10.29102757
146RPS6KL10.29102757
147IGF1R0.29014995
148BRAF0.28773547
149PRKAA10.28742058
150MAPKAPK20.28325506
151ARAF0.28231011
152MAPK30.27967267
153MAPK40.26360514
154PRKG10.26309612
155PDK10.25832184
156NTRK30.25467714
157CDK90.25317189
158PKN10.25279289
159OBSCN0.24055655
160PRPF4B0.23909919

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.11411769
2Leishmaniasis_Homo sapiens_hsa051402.92016645
3Graft-versus-host disease_Homo sapiens_hsa053322.90000028
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.77082694
5Type I diabetes mellitus_Homo sapiens_hsa049402.43985739
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.31215947
7Malaria_Homo sapiens_hsa051442.30518350
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.28669869
9Asthma_Homo sapiens_hsa053102.25834182
10Rheumatoid arthritis_Homo sapiens_hsa053232.21593918
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16295785
12Pertussis_Homo sapiens_hsa051332.13242753
13Staphylococcus aureus infection_Homo sapiens_hsa051502.11458964
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.04639440
15Hematopoietic cell lineage_Homo sapiens_hsa046401.91362353
16Osteoclast differentiation_Homo sapiens_hsa043801.90940609
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.90256740
18Legionellosis_Homo sapiens_hsa051341.89748641
19Measles_Homo sapiens_hsa051621.88248655
20Gap junction_Homo sapiens_hsa045401.87889376
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.84477930
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.83367603
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.81327992
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.78085588
25Dilated cardiomyopathy_Homo sapiens_hsa054141.77776682
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.74478315
27Renal cell carcinoma_Homo sapiens_hsa052111.72375644
28African trypanosomiasis_Homo sapiens_hsa051431.70925221
29Autoimmune thyroid disease_Homo sapiens_hsa053201.70709849
30Focal adhesion_Homo sapiens_hsa045101.70686129
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.67792709
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.66487396
33Tuberculosis_Homo sapiens_hsa051521.61945064
34Pancreatic cancer_Homo sapiens_hsa052121.50261838
35B cell receptor signaling pathway_Homo sapiens_hsa046621.50073985
36Fatty acid biosynthesis_Homo sapiens_hsa000611.48225235
37VEGF signaling pathway_Homo sapiens_hsa043701.47570608
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46454555
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.41864306
40Platelet activation_Homo sapiens_hsa046111.41372045
41TNF signaling pathway_Homo sapiens_hsa046681.40631718
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.37294841
43Insulin signaling pathway_Homo sapiens_hsa049101.33297125
44Non-small cell lung cancer_Homo sapiens_hsa052231.30742995
45Phagosome_Homo sapiens_hsa041451.30339639
46Long-term potentiation_Homo sapiens_hsa047201.28072378
47Salmonella infection_Homo sapiens_hsa051321.27813958
48Long-term depression_Homo sapiens_hsa047301.25424200
49Lysosome_Homo sapiens_hsa041421.25191296
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24834319
51Influenza A_Homo sapiens_hsa051641.24731042
52Other glycan degradation_Homo sapiens_hsa005111.23089319
53Choline metabolism in cancer_Homo sapiens_hsa052311.22719361
54Protein export_Homo sapiens_hsa030601.22097922
55Chemokine signaling pathway_Homo sapiens_hsa040621.21723737
56Endometrial cancer_Homo sapiens_hsa052131.20617507
57Caffeine metabolism_Homo sapiens_hsa002321.17488199
58Prostate cancer_Homo sapiens_hsa052151.16411255
59mTOR signaling pathway_Homo sapiens_hsa041501.15756232
60Glycosaminoglycan degradation_Homo sapiens_hsa005311.15116036
61Thyroid cancer_Homo sapiens_hsa052161.14416540
62Toxoplasmosis_Homo sapiens_hsa051451.13486821
63Herpes simplex infection_Homo sapiens_hsa051681.13106863
64Primary immunodeficiency_Homo sapiens_hsa053401.12960921
65Adherens junction_Homo sapiens_hsa045201.11673773
66Phospholipase D signaling pathway_Homo sapiens_hsa040721.10262099
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08539345
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05371354
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03777450
70Pancreatic secretion_Homo sapiens_hsa049721.03531955
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01273428
72Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01156005
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01010351
74Glioma_Homo sapiens_hsa052141.00049951
75ErbB signaling pathway_Homo sapiens_hsa040120.96278332
76Type II diabetes mellitus_Homo sapiens_hsa049300.93849121
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93538266
78Alcoholism_Homo sapiens_hsa050340.91019130
79Oxytocin signaling pathway_Homo sapiens_hsa049210.89779006
80GnRH signaling pathway_Homo sapiens_hsa049120.86526527
81Shigellosis_Homo sapiens_hsa051310.85026092
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84592775
83HIF-1 signaling pathway_Homo sapiens_hsa040660.83492176
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.80733991
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79023747
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78565691
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78096441
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78063134
89Hepatitis B_Homo sapiens_hsa051610.76646744
90Olfactory transduction_Homo sapiens_hsa047400.76147951
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76143792
92Collecting duct acid secretion_Homo sapiens_hsa049660.75442458
93Complement and coagulation cascades_Homo sapiens_hsa046100.74871674
94Viral carcinogenesis_Homo sapiens_hsa052030.73823153
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73536946
96Insulin resistance_Homo sapiens_hsa049310.72703521
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72591276
98AMPK signaling pathway_Homo sapiens_hsa041520.72457097
99Antigen processing and presentation_Homo sapiens_hsa046120.72156993
100Rap1 signaling pathway_Homo sapiens_hsa040150.71644550
101Small cell lung cancer_Homo sapiens_hsa052220.71455570
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71397878
103Morphine addiction_Homo sapiens_hsa050320.70439887
104Endocytosis_Homo sapiens_hsa041440.67667619
105Apoptosis_Homo sapiens_hsa042100.67644046
106Inositol phosphate metabolism_Homo sapiens_hsa005620.65921302
107Cholinergic synapse_Homo sapiens_hsa047250.65766015
108Amoebiasis_Homo sapiens_hsa051460.65244030
109Parkinsons disease_Homo sapiens_hsa050120.64519623
110Thyroid hormone synthesis_Homo sapiens_hsa049180.62642228
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.61258605
112Prolactin signaling pathway_Homo sapiens_hsa049170.61257800
113Viral myocarditis_Homo sapiens_hsa054160.60955424
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60877780
115Steroid biosynthesis_Homo sapiens_hsa001000.60289263
116FoxO signaling pathway_Homo sapiens_hsa040680.60217238
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60081182
118Acute myeloid leukemia_Homo sapiens_hsa052210.59942272
119Oxidative phosphorylation_Homo sapiens_hsa001900.58922376
120Circadian entrainment_Homo sapiens_hsa047130.58822783
121Proteoglycans in cancer_Homo sapiens_hsa052050.57609940
122Cocaine addiction_Homo sapiens_hsa050300.57550457
123MAPK signaling pathway_Homo sapiens_hsa040100.57160646
124Estrogen signaling pathway_Homo sapiens_hsa049150.56864276
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55961416
126Melanoma_Homo sapiens_hsa052180.52952111
127Bladder cancer_Homo sapiens_hsa052190.52898334
128Prion diseases_Homo sapiens_hsa050200.52100415
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51422359
130Arachidonic acid metabolism_Homo sapiens_hsa005900.51240509
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50995240
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50021244
133Hepatitis C_Homo sapiens_hsa051600.49820821
134Amphetamine addiction_Homo sapiens_hsa050310.49706493
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49256244
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.49245786
137Systemic lupus erythematosus_Homo sapiens_hsa053220.48704529
138Arginine and proline metabolism_Homo sapiens_hsa003300.48036183
139Gastric acid secretion_Homo sapiens_hsa049710.47534622
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46446009
141Pathways in cancer_Homo sapiens_hsa052000.46369009
142Calcium signaling pathway_Homo sapiens_hsa040200.45014470
143ABC transporters_Homo sapiens_hsa020100.44824771
144Serotonergic synapse_Homo sapiens_hsa047260.44638011
145Colorectal cancer_Homo sapiens_hsa052100.44358814
146Renin secretion_Homo sapiens_hsa049240.42753466
147Ribosome_Homo sapiens_hsa030100.42230080
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41712970
149Vibrio cholerae infection_Homo sapiens_hsa051100.41174688
150Alzheimers disease_Homo sapiens_hsa050100.40085089
151Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37795124
152Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36538225
153ECM-receptor interaction_Homo sapiens_hsa045120.35622233
154Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34753228
155Chronic myeloid leukemia_Homo sapiens_hsa052200.32075232
156Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30388931
157Ovarian steroidogenesis_Homo sapiens_hsa049130.28615713
158Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28615260
159Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27941136
160Nicotine addiction_Homo sapiens_hsa050330.27471697
161Vascular smooth muscle contraction_Homo sapiens_hsa042700.25534098
162Sphingolipid metabolism_Homo sapiens_hsa006000.23199074
163Purine metabolism_Homo sapiens_hsa002300.20843247
164Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20646297
165Starch and sucrose metabolism_Homo sapiens_hsa005000.19523807
166Neurotrophin signaling pathway_Homo sapiens_hsa047220.19209151
167Renin-angiotensin system_Homo sapiens_hsa046140.19017479

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