ARHGAP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)6.67716459
2purine nucleobase biosynthetic process (GO:0009113)5.36430542
3metaphase plate congression (GO:0051310)5.21021505
4regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.88000527
5DNA replication checkpoint (GO:0000076)4.84012727
6nucleobase biosynthetic process (GO:0046112)4.77248806
7protein localization to kinetochore (GO:0034501)4.66850128
8melanin biosynthetic process (GO:0042438)4.65272679
9protein localization to chromosome, centromeric region (GO:0071459)4.60767194
10regulation of spindle organization (GO:0090224)4.59829621
11regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.54610468
12intestinal epithelial cell development (GO:0060576)4.27127332
13protein K6-linked ubiquitination (GO:0085020)4.26721122
14establishment of chromosome localization (GO:0051303)4.25359067
15secondary metabolite biosynthetic process (GO:0044550)4.21866056
16regulation of telomere maintenance via telomerase (GO:0032210)4.16587020
17positive regulation of chromosome segregation (GO:0051984)4.15131723
18ribosome assembly (GO:0042255)4.06380109
19DNA deamination (GO:0045006)3.99699854
20positive regulation of mitotic sister chromatid separation (GO:1901970)3.98281351
21positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.98281351
22positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.98281351
23melanin metabolic process (GO:0006582)3.97779177
24regulation of transcription from RNA polymerase I promoter (GO:0006356)3.94287275
25proteasome assembly (GO:0043248)3.91216378
26mitotic sister chromatid segregation (GO:0000070)3.90945551
27mitotic chromosome condensation (GO:0007076)3.88125459
28ribosome biogenesis (GO:0042254)3.85750972
29DNA replication initiation (GO:0006270)3.84435446
30regulation of mitotic spindle organization (GO:0060236)3.83809200
31interferon-gamma secretion (GO:0072643)3.82156508
32keratinocyte development (GO:0003334)3.80091066
33regulation of hippo signaling (GO:0035330)3.78140894
34folic acid metabolic process (GO:0046655)3.78080205
35CENP-A containing nucleosome assembly (GO:0034080)3.72450591
36protein localization to chromosome (GO:0034502)3.68608881
37chromatin remodeling at centromere (GO:0031055)3.67863099
38respiratory chain complex IV assembly (GO:0008535)3.63715524
39paraxial mesoderm development (GO:0048339)3.63026424
40regulation of sister chromatid cohesion (GO:0007063)3.62195642
41mitotic nuclear envelope disassembly (GO:0007077)3.61908337
42DNA replication-dependent nucleosome assembly (GO:0006335)3.61018730
43DNA replication-dependent nucleosome organization (GO:0034723)3.61018730
44kinetochore assembly (GO:0051382)3.56382319
45DNA replication-independent nucleosome organization (GO:0034724)3.55170326
46DNA replication-independent nucleosome assembly (GO:0006336)3.55170326
47rRNA modification (GO:0000154)3.54075793
48negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.51938257
49meiotic chromosome segregation (GO:0045132)3.50901812
50maturation of SSU-rRNA (GO:0030490)3.50234782
51regulation of posttranscriptional gene silencing (GO:0060147)3.49221930
52regulation of gene silencing by miRNA (GO:0060964)3.49221930
53regulation of gene silencing by RNA (GO:0060966)3.49221930
54microtubule depolymerization (GO:0007019)3.47439299
55regulation of chromosome segregation (GO:0051983)3.40644684
56histone exchange (GO:0043486)3.39955799
57nuclear envelope disassembly (GO:0051081)3.34264206
58membrane disassembly (GO:0030397)3.34264206
59formation of translation preinitiation complex (GO:0001731)3.33737312
60nuclear pore organization (GO:0006999)3.26445471
61maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.24982969
62ribonucleoprotein complex biogenesis (GO:0022613)3.23681786
63negative regulation of keratinocyte proliferation (GO:0010839)3.23210679
64attachment of spindle microtubules to kinetochore (GO:0008608)3.23025802
65pseudouridine synthesis (GO:0001522)3.21475019
66sister chromatid segregation (GO:0000819)3.21024771
67regulation of nuclear cell cycle DNA replication (GO:0033262)3.18745716
68chromosome segregation (GO:0007059)3.18480436
69maturation of 5.8S rRNA (GO:0000460)3.18141651
70kinetochore organization (GO:0051383)3.17448655
71nuclear pore complex assembly (GO:0051292)3.16427189
72regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.16036830
73regulation of mitotic spindle checkpoint (GO:1903504)3.16036830
74cytochrome complex assembly (GO:0017004)3.14033185
75histone H2A monoubiquitination (GO:0035518)3.10759578
76blastocyst development (GO:0001824)3.09812243
77IMP biosynthetic process (GO:0006188)3.08859909
78piRNA metabolic process (GO:0034587)3.08671725
79lung-associated mesenchyme development (GO:0060484)3.07976356
80mitotic G2/M transition checkpoint (GO:0044818)3.05926439
81mitochondrial RNA metabolic process (GO:0000959)3.05802513
82folic acid transport (GO:0015884)3.05496095
83DNA double-strand break processing (GO:0000729)3.04712107
84negative regulation of telomere maintenance (GO:0032205)3.04380556
85regulation of mitotic metaphase/anaphase transition (GO:0030071)3.00071847
86spindle checkpoint (GO:0031577)2.99131630
87cardiac right ventricle morphogenesis (GO:0003215)2.98159963
88regulation of RNA export from nucleus (GO:0046831)2.97288632
89rRNA processing (GO:0006364)2.97128814
90regulation of mitochondrial translation (GO:0070129)2.95392005
91anterior/posterior axis specification, embryo (GO:0008595)2.95043666
92snRNA transcription (GO:0009301)2.94402356
93protein complex biogenesis (GO:0070271)2.93286075
94mitochondrial respiratory chain complex assembly (GO:0033108)2.93147601
95rRNA metabolic process (GO:0016072)2.92518562
96regulation of helicase activity (GO:0051095)2.92470952
97regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91967684
98positive regulation of SMAD protein import into nucleus (GO:0060391)2.91594201
99transcription elongation from RNA polymerase II promoter (GO:0006368)2.90360907
100peptidyl-histidine modification (GO:0018202)2.89099257
101resolution of meiotic recombination intermediates (GO:0000712)2.88614806
1027-methylguanosine RNA capping (GO:0009452)2.88289502
103RNA capping (GO:0036260)2.88289502
104regulation of double-strand break repair via homologous recombination (GO:0010569)2.88210271
105regulation of exit from mitosis (GO:0007096)2.88177285
106termination of RNA polymerase III transcription (GO:0006386)2.88107179
107transcription elongation from RNA polymerase III promoter (GO:0006385)2.88107179
108cullin deneddylation (GO:0010388)2.85233602
109G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.84984666
110replication fork processing (GO:0031297)2.83510010
111negative regulation of chromosome segregation (GO:0051985)2.81738184
112DNA methylation involved in gamete generation (GO:0043046)2.80713308
113water-soluble vitamin biosynthetic process (GO:0042364)2.80592290
114cellular response to nitric oxide (GO:0071732)2.80452047
115inner cell mass cell proliferation (GO:0001833)2.79983918
116negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.79641332
117negative regulation of DNA-templated transcription, elongation (GO:0032785)2.79641332
118histone H2A ubiquitination (GO:0033522)2.77898558
1197-methylguanosine mRNA capping (GO:0006370)2.77742584
120regulation of mitotic sister chromatid separation (GO:0010965)2.76427007
121regulation of mitotic sister chromatid segregation (GO:0033047)2.76427007
122regulation of sister chromatid segregation (GO:0033045)2.76427007
123mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.76244421
124DNA-templated transcription, elongation (GO:0006354)2.75925464
125regulation of cellular respiration (GO:0043457)2.75910429
126regulation of histone H3-K27 methylation (GO:0061085)2.75768094
127L-serine metabolic process (GO:0006563)2.75746962
128mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.73117197
129bundle of His cell to Purkinje myocyte communication (GO:0086069)2.71427065
130negative regulation of DNA-dependent DNA replication (GO:2000104)2.67891119
131mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66625547
132mitochondrial respiratory chain complex I assembly (GO:0032981)2.66625547
133NADH dehydrogenase complex assembly (GO:0010257)2.66625547
134chaperone-mediated protein transport (GO:0072321)2.66308828
135spliceosomal snRNP assembly (GO:0000387)2.65244872
136L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.64202413
137retinal rod cell development (GO:0046548)2.61811634
138establishment of protein localization to mitochondrial membrane (GO:0090151)2.57057002
139telomere maintenance via telomerase (GO:0007004)2.55265272
140biotin metabolic process (GO:0006768)2.53395927
141protein deneddylation (GO:0000338)2.53244909
142establishment of apical/basal cell polarity (GO:0035089)2.53185893
143regulation of cellular amino acid metabolic process (GO:0006521)2.51097318
144transcription from mitochondrial promoter (GO:0006390)2.48123328
145melanosome organization (GO:0032438)2.47257482
146prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.47010880
147negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.46551624
148mannosylation (GO:0097502)2.45996238
149recombinational repair (GO:0000725)2.45286379
150double-strand break repair via homologous recombination (GO:0000724)2.45006020
151nucleoside transmembrane transport (GO:1901642)2.43833789
152tRNA metabolic process (GO:0006399)2.43590997
153vitamin transmembrane transport (GO:0035461)2.43277963
154tRNA processing (GO:0008033)2.42293822
155transcription elongation from RNA polymerase I promoter (GO:0006362)2.41865723
156exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.41482550
157nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.40941766
158viral mRNA export from host cell nucleus (GO:0046784)2.40035606
159RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.38945754
160ATP synthesis coupled proton transport (GO:0015986)2.38932913
161energy coupled proton transport, down electrochemical gradient (GO:0015985)2.38932913
162regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.38852567
163pigment biosynthetic process (GO:0046148)2.38180973
164negative regulation of androgen receptor signaling pathway (GO:0060766)2.37123400
165branched-chain amino acid catabolic process (GO:0009083)2.37001895
166rRNA methylation (GO:0031167)2.36291746
167dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.35879264
168ketone body metabolic process (GO:1902224)2.34663694
169electron transport chain (GO:0022900)2.34562756
170pyrimidine-containing compound transmembrane transport (GO:0072531)2.34549084
171protein targeting to mitochondrion (GO:0006626)2.34474608
172tRNA aminoacylation (GO:0043039)2.31633903
173amino acid activation (GO:0043038)2.31633903
174respiratory electron transport chain (GO:0022904)2.30613007
175negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.29051635
176DNA strand elongation involved in DNA replication (GO:0006271)2.28446183
177tRNA aminoacylation for protein translation (GO:0006418)2.28067329
178ncRNA metabolic process (GO:0034660)2.26680915
179somatic hypermutation of immunoglobulin genes (GO:0016446)2.26157649

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.54444579
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.17724077
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.04124366
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.71646091
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.44705669
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.10808180
7AR_21909140_ChIP-Seq_LNCAP_Human2.99398691
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90826233
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.82004937
10NANOG_18555785_ChIP-Seq_MESCs_Mouse2.67164190
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.62179700
12ZNF274_21170338_ChIP-Seq_K562_Hela2.49840661
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.44460625
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39638699
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39193261
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34587775
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.30465517
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28913373
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.26793315
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.22328512
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.17538497
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17387836
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17222766
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.10799965
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02853761
26VDR_22108803_ChIP-Seq_LS180_Human2.01729241
27ZNF263_19887448_ChIP-Seq_K562_Human2.01172611
28KAP1_22055183_ChIP-Seq_ESCs_Mouse1.94527174
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.93459479
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.93151274
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90709765
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.90464318
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.90187565
34XRN2_22483619_ChIP-Seq_HELA_Human1.89463423
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.88682935
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.85844943
37TCF3_18692474_ChIP-Seq_MEFs_Mouse1.85230522
38NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.80722848
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.80174758
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.78083485
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.78083485
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.78083485
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.76469964
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75026586
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.73106688
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73048136
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72939178
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.70439861
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69697555
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.65819246
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65638668
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.63039104
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.62939738
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.62218417
55MYC_18940864_ChIP-ChIP_HL60_Human1.62061273
56VDR_23849224_ChIP-Seq_CD4+_Human1.57338423
57TCF3_18692474_ChIP-Seq_MESCs_Mouse1.55152087
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55006455
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.54182688
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46901974
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42333477
62GABP_19822575_ChIP-Seq_HepG2_Human1.40942371
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40561887
64KDM5A_27292631_Chip-Seq_BREAST_Human1.38526330
65TTF2_22483619_ChIP-Seq_HELA_Human1.33803468
66DCP1A_22483619_ChIP-Seq_HELA_Human1.32256594
67TP63_17297297_ChIP-ChIP_HaCaT_Human1.31793319
68IRF1_19129219_ChIP-ChIP_H3396_Human1.30788881
69* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.30262199
70NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.29893245
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28811616
72HOXB7_26014856_ChIP-Seq_BT474_Human1.28135131
73ELF5_23300383_ChIP-Seq_T47D_Human1.26848533
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.24884059
75HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24845272
76SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.24212082
77FOXP3_21729870_ChIP-Seq_TREG_Human1.23870459
78SOX2_18692474_ChIP-Seq_MEFs_Mouse1.22630740
79NANOG_18692474_ChIP-Seq_MEFs_Mouse1.22571393
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21790734
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20401467
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19106908
83ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17885834
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17684655
85* KAP1_27257070_Chip-Seq_ESCs_Mouse1.17132805
86GATA3_24758297_ChIP-Seq_MCF-7_Human1.16629482
87* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16370131
88ELK1_19687146_ChIP-ChIP_HELA_Human1.14579271
89GATA6_25053715_ChIP-Seq_YYC3_Human1.13573598
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.12152887
91NANOG_18692474_ChIP-Seq_MESCs_Mouse1.11846740
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10748413
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10265155
94EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09540246
95* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.08905148
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07141395
97NANOG_16153702_ChIP-ChIP_HESCs_Human1.07128528
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06392562
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04556692
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.04413522
101EWS_26573619_Chip-Seq_HEK293_Human1.02943215
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02201820
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02133716
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00729475
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00096343
106ELK1_22589737_ChIP-Seq_MCF10A_Human0.99895919
107POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.99246808
108ATF3_27146783_Chip-Seq_COLON_Human0.98638309
109TP53_22573176_ChIP-Seq_HFKS_Human0.96510943
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94998318
111* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.94106906
112OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93755156
113HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93324387
114SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93014007
115THAP11_20581084_ChIP-Seq_MESCs_Mouse0.92983729
116* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92832103
117FUS_26573619_Chip-Seq_HEK293_Human0.92814345
118RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92811434
119E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92485544
120YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91858060
121* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91394076
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91305625
123CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91265818
124TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90354922
125CHD1_26751641_Chip-Seq_LNCaP_Human0.90157477
126FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.89339473
127* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.88427186
128SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88406830
129TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.88236571
130PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87375787
131SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87046966
132BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86757252
133ER_23166858_ChIP-Seq_MCF-7_Human0.86692043
134* GATA4_25053715_ChIP-Seq_YYC3_Human0.86635064
135AR_20517297_ChIP-Seq_VCAP_Human0.86296128
136AHR_22903824_ChIP-Seq_MCF-7_Human0.86061275
137FOXA1_25329375_ChIP-Seq_VCAP_Human0.84504066
138FOXA1_27270436_Chip-Seq_PROSTATE_Human0.84504066
139GATA1_26923725_Chip-Seq_HPCs_Mouse0.83671408
140GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82729862
141SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81447494
142SOX2_16153702_ChIP-ChIP_HESCs_Human0.81382530
143EGR1_23403033_ChIP-Seq_LIVER_Mouse0.78710607
144ESR2_21235772_ChIP-Seq_MCF-7_Human0.78356465
145FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77123258
146HIF1A_21447827_ChIP-Seq_MCF-7_Human0.75457665

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.49054122
2MP0000372_irregular_coat_pigmentation4.84623296
3MP0004957_abnormal_blastocyst_morpholog4.05502706
4MP0003111_abnormal_nucleus_morphology3.88216293
5MP0005075_abnormal_melanosome_morpholog3.43180022
6MP0003077_abnormal_cell_cycle3.41649406
7MP0008057_abnormal_DNA_replication3.25773717
8MP0010094_abnormal_chromosome_stability3.15478131
9MP0006292_abnormal_olfactory_placode2.65938845
10MP0010352_gastrointestinal_tract_polyps2.56949815
11MP0008007_abnormal_cellular_replicative2.47958703
12MP0003718_maternal_effect2.39261594
13MP0008058_abnormal_DNA_repair2.25283267
14MP0003136_yellow_coat_color2.22313479
15MP0004381_abnormal_hair_follicle2.21171383
16MP0003806_abnormal_nucleotide_metabolis2.12046756
17MP0001730_embryonic_growth_arrest2.10785845
18MP0008932_abnormal_embryonic_tissue2.08677660
19MP0003941_abnormal_skin_development2.05244187
20MP0002653_abnormal_ependyma_morphology1.99363647
21MP0000383_abnormal_hair_follicle1.99076380
22MP0000350_abnormal_cell_proliferation1.98923753
23MP0005380_embryogenesis_phenotype1.97097282
24MP0001672_abnormal_embryogenesis/_devel1.97097282
25MP0002938_white_spotting1.94270620
26MP0002822_catalepsy1.92946619
27MP0000647_abnormal_sebaceous_gland1.89499001
28MP0004264_abnormal_extraembryonic_tissu1.89102092
29MP0003315_abnormal_perineum_morphology1.86194769
30MP0000427_abnormal_hair_cycle1.81280886
31MP0003646_muscle_fatigue1.79553354
32MP0000566_synostosis1.77208343
33MP0002085_abnormal_embryonic_tissue1.76769656
34MP0010234_abnormal_vibrissa_follicle1.76517705
35MP0005408_hypopigmentation1.69082422
36MP0001697_abnormal_embryo_size1.67999595
37MP0003984_embryonic_growth_retardation1.67933579
38MP0004185_abnormal_adipocyte_glucose1.67192040
39MP0008877_abnormal_DNA_methylation1.65576194
40MP0005171_absent_coat_pigmentation1.64843622
41MP0002088_abnormal_embryonic_growth/wei1.63710245
42MP0002736_abnormal_nociception_after1.61983475
43MP0002084_abnormal_developmental_patter1.58664355
44MP0003937_abnormal_limbs/digits/tail_de1.58523088
45MP0002086_abnormal_extraembryonic_tissu1.57823491
46MP0002095_abnormal_skin_pigmentation1.55658758
47MP0010307_abnormal_tumor_latency1.53718886
48MP0000371_diluted_coat_color1.49191735
49MP0002254_reproductive_system_inflammat1.48412983
50MP0003786_premature_aging1.46800542
51MP0003123_paternal_imprinting1.46685506
52MP0001324_abnormal_eye_pigmentation1.46535722
53MP0002080_prenatal_lethality1.40703979
54MP0000490_abnormal_crypts_of1.38723763
55MP0005076_abnormal_cell_differentiation1.38600104
56MP0002090_abnormal_vision1.37718977
57MP0002009_preneoplasia1.37320133
58MP0000015_abnormal_ear_pigmentation1.33874041
59MP0003119_abnormal_digestive_system1.32380267
60MP0009333_abnormal_splenocyte_physiolog1.32195213
61MP0003890_abnormal_embryonic-extraembry1.31532009
62MP0005451_abnormal_body_composition1.29302773
63MP0002277_abnormal_respiratory_mucosa1.27987789
64MP0001919_abnormal_reproductive_system1.24439459
65MP0000516_abnormal_urinary_system1.22189479
66MP0005367_renal/urinary_system_phenotyp1.22189479
67MP0000627_abnormal_mammary_gland1.22096255
68MP0005551_abnormal_eye_electrophysiolog1.21135978
69MP0002210_abnormal_sex_determination1.20849445
70MP0000537_abnormal_urethra_morphology1.20026280
71MP0001346_abnormal_lacrimal_gland1.19423401
72MP0002796_impaired_skin_barrier1.18879951
73MP0001145_abnormal_male_reproductive1.18081634
74MP0001485_abnormal_pinna_reflex1.17302149
75MP0001849_ear_inflammation1.17190555
76MP0000462_abnormal_digestive_system1.17014107
77MP0005646_abnormal_pituitary_gland1.16414731
78MP0008872_abnormal_physiological_respon1.13664706
79MP0002877_abnormal_melanocyte_morpholog1.12995021
80MP0004133_heterotaxia1.12680948
81MP0010030_abnormal_orbit_morphology1.11597378
82MP0005310_abnormal_salivary_gland1.11163289
83MP0002075_abnormal_coat/hair_pigmentati1.11123156
84MP0002160_abnormal_reproductive_system1.09997131
85MP0001968_abnormal_touch/_nociception1.07918463
86MP0000653_abnormal_sex_gland1.06880221
87MP0001929_abnormal_gametogenesis1.06837115
88MP0004197_abnormal_fetal_growth/weight/1.05842497
89MP0000377_abnormal_hair_follicle1.04855262
90MP0002019_abnormal_tumor_incidence1.02993577
91MP0003828_pulmonary_edema1.01563362
92MP0005174_abnormal_tail_pigmentation1.01412128
93MP0003936_abnormal_reproductive_system1.01379295
94MP0003567_abnormal_fetal_cardiomyocyte1.00483783
95MP0001293_anophthalmia0.99605874
96MP0003787_abnormal_imprinting0.98708375
97MP0001881_abnormal_mammary_gland0.97880577
98MP0001119_abnormal_female_reproductive0.96303147
99MP0006035_abnormal_mitochondrial_morpho0.95882355
100MP0005395_other_phenotype0.95025076
101MP0004147_increased_porphyrin_level0.94431933
102MP0002234_abnormal_pharynx_morphology0.94359172
103MP0001186_pigmentation_phenotype0.93016526
104MP0003705_abnormal_hypodermis_morpholog0.92782311
105MP0000538_abnormal_urinary_bladder0.91247884
106MP0005501_abnormal_skin_physiology0.91177223
107MP0001188_hyperpigmentation0.90375971
108MP0005670_abnormal_white_adipose0.90153668
109MP0005621_abnormal_cell_physiology0.89144163
110MP0003186_abnormal_redox_activity0.86691887
111MP0002098_abnormal_vibrissa_morphology0.85742577
112MP0000313_abnormal_cell_death0.85710837
113MP0002751_abnormal_autonomic_nervous0.85564452
114MP0004782_abnormal_surfactant_physiolog0.84370210
115MP0003453_abnormal_keratinocyte_physiol0.84129581
116MP0009672_abnormal_birth_weight0.83447901
117MP0003755_abnormal_palate_morphology0.83185860
118MP0003938_abnormal_ear_development0.83141830
119MP0003566_abnormal_cell_adhesion0.82202523
120MP0009053_abnormal_anal_canal0.81833147
121MP0010678_abnormal_skin_adnexa0.80986273
122MP0000613_abnormal_salivary_gland0.80862132
123MP0005377_hearing/vestibular/ear_phenot0.80486655
124MP0003878_abnormal_ear_physiology0.80486655
125MP0003195_calcinosis0.80090675
126MP0001873_stomach_inflammation0.79772592
127MP0005187_abnormal_penis_morphology0.78997246
128MP0001216_abnormal_epidermal_layer0.77232909
129MP0000467_abnormal_esophagus_morphology0.76963055
130MP0001286_abnormal_eye_development0.76737086
131MP0005389_reproductive_system_phenotype0.75877272
132MP0003935_abnormal_craniofacial_develop0.75830233
133MP0003221_abnormal_cardiomyocyte_apopto0.75249493
134MP0003699_abnormal_female_reproductive0.75236837
135MP0002697_abnormal_eye_size0.75088647
136MP0009780_abnormal_chondrocyte_physiolo0.74638407
137MP0000579_abnormal_nail_morphology0.74438220
138MP0000631_abnormal_neuroendocrine_gland0.74434450
139MP0005253_abnormal_eye_physiology0.73833461
140MP0008995_early_reproductive_senescence0.73459681
141MP0008875_abnormal_xenobiotic_pharmacok0.73232855
142MP0005023_abnormal_wound_healing0.73212437
143MP0005410_abnormal_fertilization0.71272624
144MP0005248_abnormal_Harderian_gland0.70950078
145MP0000477_abnormal_intestine_morphology0.70646394
146MP0002876_abnormal_thyroid_physiology0.70577329
147MP0005384_cellular_phenotype0.69131938
148MP0002102_abnormal_ear_morphology0.69012392
149MP0000432_abnormal_head_morphology0.67049964
150MP0002249_abnormal_larynx_morphology0.66505169
151MP0001661_extended_life_span0.66496579

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)6.75043561
2Birth length less than 3rd percentile (HP:0003561)6.01082790
3Shawl scrotum (HP:0000049)4.46451838
4Patellar aplasia (HP:0006443)4.14948044
5Abnormality of the labia minora (HP:0012880)3.91045084
6Aplasia/Hypoplasia of the patella (HP:0006498)3.86947469
7Absent radius (HP:0003974)3.83312513
8Facial hemangioma (HP:0000329)3.74715640
9Congenital stationary night blindness (HP:0007642)3.69020978
10Breast aplasia (HP:0100783)3.66282360
11Aplasia involving forearm bones (HP:0009822)3.65895981
12Absent forearm bone (HP:0003953)3.65895981
13Carpal bone hypoplasia (HP:0001498)3.65460378
14Aplasia/Hypoplasia of the breasts (HP:0010311)3.52063224
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.40834802
16Chromsome breakage (HP:0040012)3.38303582
17Supernumerary spleens (HP:0009799)3.14867788
18Oral leukoplakia (HP:0002745)3.14351461
19Aplasia/Hypoplasia of the macula (HP:0008059)3.13868902
20Rhabdomyosarcoma (HP:0002859)3.11296538
21Meckel diverticulum (HP:0002245)3.10606002
22Abnormality of the preputium (HP:0100587)2.91191523
23Aplasia/Hypoplasia affecting the retina (HP:0008061)2.89840092
24Abnormality of the ileum (HP:0001549)2.87793710
25Cerebral hypomyelination (HP:0006808)2.86726694
26Aplasia/hypoplasia of the humerus (HP:0006507)2.85495675
27Acute encephalopathy (HP:0006846)2.83350699
28Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.80503320
29Selective tooth agenesis (HP:0001592)2.73947662
30Absent thumb (HP:0009777)2.72326185
31Amelogenesis imperfecta (HP:0000705)2.72270554
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.71206324
33Aplasia/Hypoplasia of the fovea (HP:0008060)2.70104366
34Hypoplasia of the fovea (HP:0007750)2.70104366
35Increased CSF lactate (HP:0002490)2.69414135
36Rough bone trabeculation (HP:0100670)2.68813623
37Acute necrotizing encephalopathy (HP:0006965)2.66378071
38Aplastic anemia (HP:0001915)2.63874044
39Colon cancer (HP:0003003)2.61513001
40Capillary hemangiomas (HP:0005306)2.61017038
41Abnormality of chromosome stability (HP:0003220)2.60882884
42Trismus (HP:0000211)2.60397378
43Sparse lateral eyebrow (HP:0005338)2.58459008
44Decreased central vision (HP:0007663)2.56774673
45Abnormality of cochlea (HP:0000375)2.55136183
46Multiple enchondromatosis (HP:0005701)2.52926585
47Anal stenosis (HP:0002025)2.52186770
48Premature ovarian failure (HP:0008209)2.52071471
49Abnormal spermatogenesis (HP:0008669)2.51041999
50Azoospermia (HP:0000027)2.50729560
51Duodenal stenosis (HP:0100867)2.47457555
52Small intestinal stenosis (HP:0012848)2.47457555
53Abdominal situs inversus (HP:0003363)2.45625315
54Abnormality of abdominal situs (HP:0011620)2.45625315
55Mitochondrial inheritance (HP:0001427)2.43969514
56Neoplasm of the pancreas (HP:0002894)2.43870954
57Ocular albinism (HP:0001107)2.43377701
58Tracheoesophageal fistula (HP:0002575)2.40905112
59Abnormal mitochondria in muscle tissue (HP:0008316)2.40465347
60Aplasia/Hypoplasia involving the musculature (HP:0001460)2.40383050
61Curly hair (HP:0002212)2.39762563
62Pancreatic cysts (HP:0001737)2.39274924
63Hyperglycinuria (HP:0003108)2.36071063
64Short humerus (HP:0005792)2.35404382
65Oligodactyly (HP:0012165)2.35348527
66Blepharitis (HP:0000498)2.34904064
67Septate vagina (HP:0001153)2.34594225
68Iris hypopigmentation (HP:0007730)2.33765742
69Horseshoe kidney (HP:0000085)2.32909645
70Microretrognathia (HP:0000308)2.32806859
71Bilateral microphthalmos (HP:0007633)2.28277371
72Ectopic kidney (HP:0000086)2.28170610
73Myelodysplasia (HP:0002863)2.27180808
74Ependymoma (HP:0002888)2.26106393
75Lipid accumulation in hepatocytes (HP:0006561)2.25996919
76Increased hepatocellular lipid droplets (HP:0006565)2.22245085
77Reticulocytopenia (HP:0001896)2.22108233
78Triphalangeal thumb (HP:0001199)2.21137543
79Hepatocellular necrosis (HP:0001404)2.18965535
80Aplasia/Hypoplasia of the sternum (HP:0006714)2.18944506
81Male infertility (HP:0003251)2.18869396
82Neoplasm of striated muscle (HP:0009728)2.18456725
83Impulsivity (HP:0100710)2.18218914
84Esophageal atresia (HP:0002032)2.17174705
85Secondary amenorrhea (HP:0000869)2.17022358
86Abnormality of the fovea (HP:0000493)2.16836066
87Hyperalaninemia (HP:0003348)2.14629871
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14629871
89Abnormality of alanine metabolism (HP:0010916)2.14629871
90Bone marrow hypocellularity (HP:0005528)2.12948595
91Delayed puberty (HP:0000823)2.12435729
92Increased serum lactate (HP:0002151)2.09708875
93Atresia of the external auditory canal (HP:0000413)2.09603409
94Progressive muscle weakness (HP:0003323)2.09340347
95Progressive macrocephaly (HP:0004481)2.08001659
96Abnormality of the duodenum (HP:0002246)2.07374062
97Short thumb (HP:0009778)2.06241529
98Hypoplasia of the pons (HP:0012110)2.05714458
99Breech presentation (HP:0001623)2.04065730
100Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.02907972
101Right ventricular cardiomyopathy (HP:0011663)2.02702360
102Hypopigmentation of the fundus (HP:0007894)2.01085408
103Hypomagnesemia (HP:0002917)2.00584290
104Bifid tongue (HP:0010297)1.99820405
105Abnormality of the pons (HP:0007361)1.98195023
106Onycholysis (HP:0001806)1.97522509
107Cleft eyelid (HP:0000625)1.97399442
108Abnormality of the astrocytes (HP:0100707)1.96826940
109Astrocytoma (HP:0009592)1.96826940
110Abnormal trabecular bone morphology (HP:0100671)1.96206805
111Abnormality of midbrain morphology (HP:0002418)1.95966873
112Molar tooth sign on MRI (HP:0002419)1.95966873
113Pendular nystagmus (HP:0012043)1.94119578
114True hermaphroditism (HP:0010459)1.93443153
115Hypoplasia of the radius (HP:0002984)1.92885424
116Abnormality of the proximal phalanges of the hand (HP:0009834)1.92083196
117Bicornuate uterus (HP:0000813)1.91755381
118Hepatic necrosis (HP:0002605)1.91681601
119Aplasia/hypoplasia of the uterus (HP:0008684)1.91467132
120Breast carcinoma (HP:0003002)1.90281420
121Adrenal hypoplasia (HP:0000835)1.89721629
122Abnormality of glycine metabolism (HP:0010895)1.89033986
123Abnormality of serine family amino acid metabolism (HP:0010894)1.89033986
124Abnormality of cells of the erythroid lineage (HP:0012130)1.88947210
125Cerebellar dysplasia (HP:0007033)1.88328337
126CNS hypomyelination (HP:0003429)1.87931799
127Glioma (HP:0009733)1.87599115
128Aplasia/Hypoplasia of the ulna (HP:0006495)1.86997272
129Hypoplastic labia majora (HP:0000059)1.86729013
130Type I transferrin isoform profile (HP:0003642)1.86510935
131Nail dystrophy (HP:0008404)1.86296809
132Rib fusion (HP:0000902)1.85833824
133Sparse eyelashes (HP:0000653)1.84733557
134Abnormality of methionine metabolism (HP:0010901)1.83264143
135Horizontal nystagmus (HP:0000666)1.83179043
136Abnormal lung lobation (HP:0002101)1.81952285
137Milia (HP:0001056)1.81642802
138Pili torti (HP:0003777)1.81329747
139Abnormal protein glycosylation (HP:0012346)1.80959951
140Abnormal glycosylation (HP:0012345)1.80959951
141Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80959951
142Abnormal protein N-linked glycosylation (HP:0012347)1.80959951
143Absent hand (HP:0004050)1.80391875
144Abnormality of the renal cortex (HP:0011035)1.80296308
145Prostate neoplasm (HP:0100787)1.80286753
146Pancreatic fibrosis (HP:0100732)1.80162926
147Absent eyebrow (HP:0002223)1.78792627
148Tongue fasciculations (HP:0001308)1.78520239
149Oligodactyly (hands) (HP:0001180)1.78029697
150Chronic bronchitis (HP:0004469)1.77150910
151Abnormality of sulfur amino acid metabolism (HP:0004339)1.77080793
152Tubular atrophy (HP:0000092)1.76557307
153Abnormal number of erythroid precursors (HP:0012131)1.76442655
154Lactic acidosis (HP:0003128)1.75452550
155Facial cleft (HP:0002006)1.75383723
156Cerebral edema (HP:0002181)1.74729824
157Nephronophthisis (HP:0000090)1.73746322
158Squamous cell carcinoma (HP:0002860)1.73415304
159Biliary tract neoplasm (HP:0100574)1.72059220
160Lip pit (HP:0100267)1.71731522
161Testicular atrophy (HP:0000029)1.71198211
162Medulloblastoma (HP:0002885)1.70912301
163Fused cervical vertebrae (HP:0002949)1.70649990
164Methylmalonic aciduria (HP:0012120)1.70571791
165Renal Fanconi syndrome (HP:0001994)1.69596087
166Concave nail (HP:0001598)1.69415121
167Degeneration of anterior horn cells (HP:0002398)1.68044946
168Abnormality of the anterior horn cell (HP:0006802)1.68044946
169Abnormality of magnesium homeostasis (HP:0004921)1.67905386
170Progressive inability to walk (HP:0002505)1.66675864
171Type II lissencephaly (HP:0007260)1.65686880
172Abnormality of homocysteine metabolism (HP:0010919)1.65253104
173Homocystinuria (HP:0002156)1.65253104
174Abnormality of the parathyroid morphology (HP:0011766)1.65051857
175Amblyopia (HP:0000646)1.64890661
176Anophthalmia (HP:0000528)1.64733346
177Megaloblastic anemia (HP:0001889)1.64498291
178Sloping forehead (HP:0000340)1.64479782
179Lethargy (HP:0001254)1.64423296

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS24.40089042
2EPHA24.35427764
3AKT34.23264101
4WEE14.03872692
5LATS13.56548629
6STK38L3.51565497
7BUB13.18071970
8NEK23.08260132
9NLK2.49736364
10SRPK12.43069172
11TRIM282.33905977
12MST1R2.32326739
13STK392.31386442
14TTK2.29191568
15DYRK32.19165857
16BMPR1B2.16370025
17CDC72.15009385
18PBK2.11096535
19RPS6KB22.07750739
20VRK22.02420239
21BRSK22.00498865
22CDK121.94409822
23PLK11.88930527
24WNK41.86703531
25EIF2AK11.79825898
26MUSK1.78394954
27OXSR11.76302040
28STK31.75053545
29PLK41.71672551
30NUAK11.71640217
31ACVR1B1.71418695
32AURKB1.70243778
33WNK31.55513146
34TNIK1.51442629
35CDK41.51395191
36CDK71.48305222
37CHEK21.48286405
38PRKCI1.45023191
39NME21.35659236
40GRK11.35415167
41MAP4K21.33185770
42CSNK1G11.27773461
43STK161.27251168
44IRAK31.26544439
45DYRK21.21169049
46RPS6KA41.16595950
47CSNK1G31.14690761
48AURKA1.13799224
49CSNK1A1L1.12853194
50BCKDK1.11862640
51PLK31.07241118
52EIF2AK31.07230172
53FRK1.06917804
54MKNK21.03864934
55MST41.02674522
56LMTK21.01998097
57CAMK1D1.01463527
58PKN20.99447221
59INSRR0.97210449
60CHEK10.96851009
61TAF10.96530541
62ZAK0.96192926
63NEK10.95904185
64PAK10.95784501
65MAPKAPK30.91037169
66PDK20.90495313
67TESK20.89386416
68MAP3K120.89358983
69FGFR20.87847544
70CSNK1G20.87832192
71MELK0.86360997
72BRSK10.85288867
73CHUK0.85232725
74STK380.84823618
75NME10.84314632
76MAP3K80.82772777
77DYRK1A0.80115068
78MAP3K60.77676888
79ABL20.76397780
80ADRBK20.74524834
81MARK30.73756683
82TLK10.72620991
83MAP3K30.66346531
84SGK20.66140988
85SIK30.64370216
86STK100.64294176
87CDK20.63697318
88TNK20.62874828
89NEK60.62520606
90CSNK1A10.62309418
91PIK3CA0.62130657
92TSSK60.61446015
93EIF2AK20.61325907
94CAMK1G0.60402407
95CASK0.60255505
96DDR20.59088462
97ATR0.57750054
98DAPK10.57392854
99CDK90.56701465
100KSR20.55295581
101ILK0.55283834
102ERBB40.54981784
103VRK10.54469017
104AKT20.52364104
105MAPK150.51815144
106ERBB20.51311250
107PIM10.50745903
108CDK30.49516995
109MKNK10.49403075
110FGFR10.47926676
111ATM0.47827039
112RAF10.47799069
113TRIB30.44728544
114PAK30.43805983
115CDK10.43686135
116PRKCE0.42283444
117MAP2K70.41131641
118CDK80.41117227
119SGK30.40471786
120CDK60.40450219
121MATK0.39734509
122BRAF0.39555986
123ZAP700.39485663
124STK40.38604029
125CSNK1D0.38593367
126PLK20.38510179
127MAP2K60.38115077
128STK240.37774744
129PAK20.37617973
130EEF2K0.36384551
131PDK30.35613651
132PDK40.35613651
133MTOR0.33334054
134BCR0.33278167
135GSK3A0.31863632
136PAK40.30948649
137CSNK2A10.30300291
138TAOK30.30117020
139ALK0.29322047
140PTK20.28698713
141MAP2K20.26007641
142NEK90.25963439
143MET0.25715612
144MAP3K90.23583101
145KSR10.23241277
146CSNK2A20.21486308
147FER0.20446200
148CSNK1E0.20330223
149BRD40.18869619

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.59147026
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.29413288
3RNA transport_Homo sapiens_hsa030133.45062770
4Cell cycle_Homo sapiens_hsa041103.23920896
5DNA replication_Homo sapiens_hsa030303.00829978
6Fanconi anemia pathway_Homo sapiens_hsa034602.75828243
7Mismatch repair_Homo sapiens_hsa034302.71649896
8Basal transcription factors_Homo sapiens_hsa030222.66642326
9Spliceosome_Homo sapiens_hsa030402.66113061
10p53 signaling pathway_Homo sapiens_hsa041152.45757240
11Homologous recombination_Homo sapiens_hsa034402.43834471
12Oxidative phosphorylation_Homo sapiens_hsa001902.39024690
13Cyanoamino acid metabolism_Homo sapiens_hsa004602.37049553
14Nucleotide excision repair_Homo sapiens_hsa034202.33221398
15Pyrimidine metabolism_Homo sapiens_hsa002402.29597996
16Base excision repair_Homo sapiens_hsa034102.14164504
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.13660923
18Ribosome_Homo sapiens_hsa030102.13386698
19Parkinsons disease_Homo sapiens_hsa050121.89529836
20mRNA surveillance pathway_Homo sapiens_hsa030151.86793963
21One carbon pool by folate_Homo sapiens_hsa006701.78542072
22RNA degradation_Homo sapiens_hsa030181.73652135
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69688311
24Protein export_Homo sapiens_hsa030601.67166008
25Vitamin B6 metabolism_Homo sapiens_hsa007501.66587413
26Huntingtons disease_Homo sapiens_hsa050161.58619451
27Proteasome_Homo sapiens_hsa030501.53955895
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.52061052
29Hippo signaling pathway_Homo sapiens_hsa043901.47371662
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.44527730
31Caffeine metabolism_Homo sapiens_hsa002321.42289188
32Pentose phosphate pathway_Homo sapiens_hsa000301.40501281
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39148168
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38527079
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37285031
36Propanoate metabolism_Homo sapiens_hsa006401.35830933
37Purine metabolism_Homo sapiens_hsa002301.35121378
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32819823
39Oocyte meiosis_Homo sapiens_hsa041141.30982918
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29330229
41TGF-beta signaling pathway_Homo sapiens_hsa043501.26194801
42Steroid biosynthesis_Homo sapiens_hsa001001.25696719
43Tight junction_Homo sapiens_hsa045301.25099699
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23185065
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20581525
46Collecting duct acid secretion_Homo sapiens_hsa049661.18074012
47Basal cell carcinoma_Homo sapiens_hsa052171.15528272
48Adherens junction_Homo sapiens_hsa045201.13021085
49Epstein-Barr virus infection_Homo sapiens_hsa051691.12010611
50Phototransduction_Homo sapiens_hsa047441.08666674
51Fatty acid elongation_Homo sapiens_hsa000621.07645469
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06074114
53Pyruvate metabolism_Homo sapiens_hsa006201.05564956
54Alzheimers disease_Homo sapiens_hsa050101.05008155
55Small cell lung cancer_Homo sapiens_hsa052221.04859228
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03817989
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03275819
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97461038
59MicroRNAs in cancer_Homo sapiens_hsa052060.96968007
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96520551
61Arachidonic acid metabolism_Homo sapiens_hsa005900.95591464
62Metabolic pathways_Homo sapiens_hsa011000.93385666
63Herpes simplex infection_Homo sapiens_hsa051680.90429922
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89484634
65Tryptophan metabolism_Homo sapiens_hsa003800.89344492
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87457869
67Biosynthesis of amino acids_Homo sapiens_hsa012300.85735425
68Non-homologous end-joining_Homo sapiens_hsa034500.85521776
69Hedgehog signaling pathway_Homo sapiens_hsa043400.84760012
70Sulfur metabolism_Homo sapiens_hsa009200.84280863
71Tyrosine metabolism_Homo sapiens_hsa003500.81668816
72Linoleic acid metabolism_Homo sapiens_hsa005910.79489118
73Sulfur relay system_Homo sapiens_hsa041220.78253642
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78070630
75Thyroid cancer_Homo sapiens_hsa052160.77760537
76Folate biosynthesis_Homo sapiens_hsa007900.77088343
77Peroxisome_Homo sapiens_hsa041460.75240163
78Prostate cancer_Homo sapiens_hsa052150.73500139
79Viral carcinogenesis_Homo sapiens_hsa052030.72836835
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72719159
81Lysine degradation_Homo sapiens_hsa003100.71432402
82Chemical carcinogenesis_Homo sapiens_hsa052040.70838493
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.70617235
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70455599
85Butanoate metabolism_Homo sapiens_hsa006500.69222770
86Glutathione metabolism_Homo sapiens_hsa004800.68687126
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67860671
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67165136
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66947191
90Nitrogen metabolism_Homo sapiens_hsa009100.66683160
91Other glycan degradation_Homo sapiens_hsa005110.65640653
92beta-Alanine metabolism_Homo sapiens_hsa004100.64832817
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64435953
94HTLV-I infection_Homo sapiens_hsa051660.62193298
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61621389
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59959672
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59689680
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58020878
99Bladder cancer_Homo sapiens_hsa052190.57028978
100Fatty acid metabolism_Homo sapiens_hsa012120.56225742
101Antigen processing and presentation_Homo sapiens_hsa046120.55246562
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54789827
103Pathways in cancer_Homo sapiens_hsa052000.53853186
104Fatty acid biosynthesis_Homo sapiens_hsa000610.53565870
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.52910000
106Vibrio cholerae infection_Homo sapiens_hsa051100.52111579
107FoxO signaling pathway_Homo sapiens_hsa040680.51461228
108Arginine and proline metabolism_Homo sapiens_hsa003300.49927922
109N-Glycan biosynthesis_Homo sapiens_hsa005100.49139053
110Wnt signaling pathway_Homo sapiens_hsa043100.48559454
111Histidine metabolism_Homo sapiens_hsa003400.48380969
112Renal cell carcinoma_Homo sapiens_hsa052110.46712099
113Regulation of autophagy_Homo sapiens_hsa041400.46520454
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45609826
115Circadian rhythm_Homo sapiens_hsa047100.45250157
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43368729
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.42848673
118Systemic lupus erythematosus_Homo sapiens_hsa053220.42067604
119Taste transduction_Homo sapiens_hsa047420.41804394
120Selenocompound metabolism_Homo sapiens_hsa004500.41610048
121Sphingolipid metabolism_Homo sapiens_hsa006000.40936556
122Carbon metabolism_Homo sapiens_hsa012000.39057236
123Cardiac muscle contraction_Homo sapiens_hsa042600.37791601
124Melanoma_Homo sapiens_hsa052180.37774369
125Retinol metabolism_Homo sapiens_hsa008300.37556388
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36409594
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.35716605
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35454712
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34832157
130Drug metabolism - other enzymes_Homo sapiens_hsa009830.34257671
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.33856074
132Apoptosis_Homo sapiens_hsa042100.33193403
133Vitamin digestion and absorption_Homo sapiens_hsa049770.32352381
134Hepatitis B_Homo sapiens_hsa051610.31405527
135Notch signaling pathway_Homo sapiens_hsa043300.30800993
136Fructose and mannose metabolism_Homo sapiens_hsa000510.30707681
137mTOR signaling pathway_Homo sapiens_hsa041500.29656710
138Colorectal cancer_Homo sapiens_hsa052100.29562424
139Prolactin signaling pathway_Homo sapiens_hsa049170.27839554
140Influenza A_Homo sapiens_hsa051640.26733369
141Ether lipid metabolism_Homo sapiens_hsa005650.26207483
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26107333
143Pancreatic cancer_Homo sapiens_hsa052120.25252351
144Mineral absorption_Homo sapiens_hsa049780.23698917
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22963809
146Proteoglycans in cancer_Homo sapiens_hsa052050.22884056
147Endometrial cancer_Homo sapiens_hsa052130.22282728
148Intestinal immune network for IgA production_Homo sapiens_hsa046720.22146888
149AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.16783975
150NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16014719
151Inositol phosphate metabolism_Homo sapiens_hsa005620.15546869

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