ARHGDIA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mannose metabolic process (GO:0006013)4.42608655
2GDP-mannose metabolic process (GO:0019673)4.29785339
3protein carboxylation (GO:0018214)4.23978504
4peptidyl-glutamic acid carboxylation (GO:0017187)4.23978504
5protein localization to endosome (GO:0036010)4.22235976
6negative regulation of erythrocyte differentiation (GO:0045647)4.20634915
7negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.99385768
8adenosine receptor signaling pathway (GO:0001973)3.89434887
9regulation of protein heterodimerization activity (GO:0043497)3.80797573
10regulation of mammary gland epithelial cell proliferation (GO:0033599)3.73555919
11proline biosynthetic process (GO:0006561)3.72190583
12COPI coating of Golgi vesicle (GO:0048205)3.65326766
13Golgi transport vesicle coating (GO:0048200)3.65326766
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.60975167
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.60975167
16Arp2/3 complex-mediated actin nucleation (GO:0034314)3.60826635
17modulation by symbiont of host cellular process (GO:0044068)3.54323626
18endocytic recycling (GO:0032456)3.49590875
19modulation by virus of host process (GO:0019054)3.47244576
20antigen processing and presentation of endogenous antigen (GO:0019883)3.43522222
21DNA unwinding involved in DNA replication (GO:0006268)3.39845542
22T cell apoptotic process (GO:0070231)3.36159047
23positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.34304625
24UV protection (GO:0009650)3.31760607
25barbed-end actin filament capping (GO:0051016)3.23721293
26regulation of cytokine production involved in inflammatory response (GO:1900015)3.09742140
27adherens junction assembly (GO:0034333)3.05431339
28negative regulation of cell aging (GO:0090344)3.04477980
29planar cell polarity pathway involved in neural tube closure (GO:0090179)3.02376992
30negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.02114812
31cell-substrate adherens junction assembly (GO:0007045)3.00299601
32focal adhesion assembly (GO:0048041)3.00299601
33response to peptidoglycan (GO:0032494)2.99679300
34endothelial tube morphogenesis (GO:0061154)2.98828492
35morphogenesis of an endothelium (GO:0003159)2.98828492
36regulation of early endosome to late endosome transport (GO:2000641)2.98570288
37regulation of translational fidelity (GO:0006450)2.97421975
38positive regulation of lamellipodium assembly (GO:0010592)2.97320871
39heterochromatin organization (GO:0070828)2.91723888
40type B pancreatic cell proliferation (GO:0044342)2.90827203
41negative regulation of interleukin-8 production (GO:0032717)2.90790024
42lymphocyte apoptotic process (GO:0070227)2.90575910
43activation of Rac GTPase activity (GO:0032863)2.86058193
44protein localization to kinetochore (GO:0034501)2.85466464
45regulation of translational termination (GO:0006449)2.81428441
46formation of translation preinitiation complex (GO:0001731)2.81165416
47mitotic nuclear envelope disassembly (GO:0007077)2.80128027
48folic acid-containing compound biosynthetic process (GO:0009396)2.80096141
49response to muramyl dipeptide (GO:0032495)2.77651220
50positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.76366517
51cell-substrate junction assembly (GO:0007044)2.76080360
52positive regulation of Cdc42 GTPase activity (GO:0043089)2.74240325
53negative regulation of phagocytosis (GO:0050765)2.74016732
54positive regulation of lamellipodium organization (GO:1902745)2.70345537
55mitotic cell cycle arrest (GO:0071850)2.69894606
56regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.68119696
57membrane disassembly (GO:0030397)2.67522373
58nuclear envelope disassembly (GO:0051081)2.67522373
59negative regulation of fatty acid transport (GO:2000192)2.67235420
60cellular response to virus (GO:0098586)2.67130452
61maternal placenta development (GO:0001893)2.66660292
62actin filament bundle organization (GO:0061572)2.66573503
63actin filament bundle assembly (GO:0051017)2.66573503
64regulation of extracellular matrix disassembly (GO:0010715)2.66042580
65apoptotic process involved in morphogenesis (GO:0060561)2.64486422
66positive regulation of gamma-delta T cell activation (GO:0046645)2.64214676
67lens fiber cell differentiation (GO:0070306)2.63592269
68regulation of apoptotic process involved in morphogenesis (GO:1902337)2.62262548
69positive regulation of blood vessel endothelial cell migration (GO:0043536)2.61320788
70modulation by virus of host morphology or physiology (GO:0019048)2.60089333
71dosage compensation (GO:0007549)2.59712997
72apoptotic cell clearance (GO:0043277)2.58393929
73regulation of SMAD protein import into nucleus (GO:0060390)2.58281559
74negative regulation of cell size (GO:0045792)2.58264454
75glycosphingolipid catabolic process (GO:0046479)2.57031594
76activation of MAPKKK activity (GO:0000185)2.56236892
77positive regulation of SMAD protein import into nucleus (GO:0060391)2.55993406
78granulocyte differentiation (GO:0030851)2.55617070
79glucocorticoid receptor signaling pathway (GO:0042921)2.55341055
80retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.54984020
81pentose-phosphate shunt (GO:0006098)2.54748290
82vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.54654468
833-UTR-mediated mRNA stabilization (GO:0070935)2.54505309
84response to laminar fluid shear stress (GO:0034616)2.53768272
85sequestering of actin monomers (GO:0042989)2.53708009
86negative regulation of toll-like receptor signaling pathway (GO:0034122)2.53143914
87actin nucleation (GO:0045010)2.51226111
88cellular response to ATP (GO:0071318)2.49549570
89IMP biosynthetic process (GO:0006188)2.47797450
90low-density lipoprotein particle clearance (GO:0034383)2.47232919
91positive regulation of nuclease activity (GO:0032075)2.46676658
92regulation of glucose import in response to insulin stimulus (GO:2001273)2.45905005
93platelet aggregation (GO:0070527)2.45051262
94G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.44575535
95regulation of skeletal muscle contraction (GO:0014819)2.43150647
96DNA strand elongation involved in DNA replication (GO:0006271)2.42187043
97regulation of NFAT protein import into nucleus (GO:0051532)2.42114412
98regulation of gamma-delta T cell differentiation (GO:0045586)2.41465748
99regulation of synapse structural plasticity (GO:0051823)2.41165273
100activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.40520290
101stress fiber assembly (GO:0043149)2.40499481
102immunoglobulin mediated immune response (GO:0016064)2.40310490
103regulation of interleukin-12 biosynthetic process (GO:0045075)2.39462089
104negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.39340670
105positive regulation of histone deacetylation (GO:0031065)2.37592865
106adhesion of symbiont to host (GO:0044406)2.35910457
107antigen processing and presentation via MHC class Ib (GO:0002475)2.35482553
108positive regulation by symbiont of host defense response (GO:0052509)2.35109214
109modulation by symbiont of host defense response (GO:0052031)2.35109214
110modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.35109214
111modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.35109214
112positive regulation by organism of defense response of other organism involved in symbiotic interact2.35109214
113modulation by symbiont of host immune response (GO:0052553)2.35109214
114G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.34593484
115regulation of ARF GTPase activity (GO:0032312)2.34459492
116proline metabolic process (GO:0006560)2.34180383
117positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.34030785
118positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.33473222
119positive regulation of extracellular matrix organization (GO:1903055)2.32582150
120regulation of nuclease activity (GO:0032069)2.32515216
121mRNA stabilization (GO:0048255)2.32504807
122RNA stabilization (GO:0043489)2.32504807
123regulation of type I interferon-mediated signaling pathway (GO:0060338)2.32196383
124atrioventricular valve morphogenesis (GO:0003181)2.32061546
125thymic T cell selection (GO:0045061)2.31959172
126negative regulation of viral release from host cell (GO:1902187)2.31922065
127protein insertion into membrane (GO:0051205)2.31110204
128positive thymic T cell selection (GO:0045059)2.31088306
129B cell mediated immunity (GO:0019724)2.30992664
130positive regulation of protein dephosphorylation (GO:0035307)2.29561654
131* semaphorin-plexin signaling pathway (GO:0071526)2.28561238
132maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.28051626
133nuclear envelope organization (GO:0006998)2.28043693
134cortical actin cytoskeleton organization (GO:0030866)2.27878529
135activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.26572908
136leukocyte apoptotic process (GO:0071887)2.26443829
137regulation of integrin activation (GO:0033623)2.26088373
138embryonic process involved in female pregnancy (GO:0060136)2.25852607
139cell adhesion mediated by integrin (GO:0033627)2.25373501
140endodermal cell differentiation (GO:0035987)2.25109262
141glycolipid catabolic process (GO:0019377)2.25053386
142positive regulation of protein deacetylation (GO:0090312)2.24900969
143regulation of cholesterol homeostasis (GO:2000188)2.24419631
144DNA strand elongation (GO:0022616)2.24409597
145activation of JUN kinase activity (GO:0007257)2.24036705
146DNA strand renaturation (GO:0000733)2.23829300
147negative regulation of RNA splicing (GO:0033119)2.23810495
148positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.23385176
149protein localization to chromosome, centromeric region (GO:0071459)2.23241786
150regulation of defense response to virus by virus (GO:0050690)2.22319438
151pyrimidine nucleoside salvage (GO:0043097)2.22175665
152pyrimidine-containing compound salvage (GO:0008655)2.22175665
153protein retention in ER lumen (GO:0006621)2.20108227
154mitotic G1 DNA damage checkpoint (GO:0031571)2.19682565
155regulation of interferon-beta biosynthetic process (GO:0045357)2.19660718
156adhesion of symbiont to host cell (GO:0044650)2.19515124
157virion attachment to host cell (GO:0019062)2.19515124
158basement membrane organization (GO:0071711)2.18251483
159leukocyte aggregation (GO:0070486)2.16533639
160NIK/NF-kappaB signaling (GO:0038061)2.15561917
161NADPH regeneration (GO:0006740)2.15345450
162regulation of B cell receptor signaling pathway (GO:0050855)2.15141717
163IMP metabolic process (GO:0046040)2.13819389
164natural killer cell differentiation (GO:0001779)2.13807082
165leukocyte cell-cell adhesion (GO:0007159)2.13610720
166protein heterotrimerization (GO:0070208)2.12684867
167JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.11759374
168pinocytosis (GO:0006907)2.11656050
169histone-serine phosphorylation (GO:0035404)2.11622450
170hyaluronan catabolic process (GO:0030214)2.11270717
171corticosteroid receptor signaling pathway (GO:0031958)2.10202125
172negative thymic T cell selection (GO:0045060)2.09784715
173skin morphogenesis (GO:0043589)2.09542248
174nuclear pore complex assembly (GO:0051292)2.09200387

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.11723667
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.87778172
3MYC_22102868_ChIP-Seq_BL_Human3.22012811
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.19114984
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.01438850
6* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.01205611
7* VDR_21846776_ChIP-Seq_THP-1_Human2.53812502
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.30757506
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.26968660
10* ELK3_25401928_ChIP-Seq_HUVEC_Human2.12685746
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.08795714
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97877852
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85157748
14TET1_21451524_ChIP-Seq_MESCs_Mouse1.80608628
15CTCF_27219007_Chip-Seq_ERYTHROID_Human1.80121050
16MAF_26560356_Chip-Seq_TH1_Human1.79209456
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76999121
18IRF8_21731497_ChIP-ChIP_J774_Mouse1.73649370
19TCF7_22412390_ChIP-Seq_EML_Mouse1.72325328
20KDM2B_26808549_Chip-Seq_DND41_Human1.70845980
21* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.70723700
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70140704
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70061014
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.69172987
25* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65832116
26* UTX_26944678_Chip-Seq_JUKART_Human1.64198306
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61847977
28* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61501317
29SA1_27219007_Chip-Seq_ERYTHROID_Human1.61298089
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60798853
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.57266758
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56917234
33LXR_22292898_ChIP-Seq_THP-1_Human1.55945611
34* VDR_24763502_ChIP-Seq_THP-1_Human1.54962029
35SRY_22984422_ChIP-ChIP_TESTIS_Rat1.54715004
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50937931
37BCOR_27268052_Chip-Seq_Bcells_Human1.49903435
38* KDM2B_26808549_Chip-Seq_K562_Human1.49722753
39RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49522360
40* XRN2_22483619_ChIP-Seq_HELA_Human1.48575550
41* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47932801
42SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46294765
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46167427
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45967911
45CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.45640153
46* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44550744
47SMC4_20622854_ChIP-Seq_HELA_Human1.44316343
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44193658
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44074889
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42303263
51BCL6_27268052_Chip-Seq_Bcells_Human1.41409123
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40593965
53* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39592138
54* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39067826
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38414873
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37283546
57* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36867062
58CREB1_26743006_Chip-Seq_LNCaP_Human1.36133585
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.35612723
60MYB_26560356_Chip-Seq_TH2_Human1.35278286
61* ATF3_27146783_Chip-Seq_COLON_Human1.35104120
62* TFEB_21752829_ChIP-Seq_HELA_Human1.35094888
63* RACK7_27058665_Chip-Seq_MCF-7_Human1.35016809
64* ERG_21242973_ChIP-ChIP_JURKAT_Human1.34031354
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.33809579
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32861017
67* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32302076
68CIITA_25753668_ChIP-Seq_RAJI_Human1.32199800
69SPI1_23547873_ChIP-Seq_NB4_Human1.31653122
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30704726
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.30285559
72CLOCK_20551151_ChIP-Seq_293T_Human1.30157483
73* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29264965
74* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28533855
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28510154
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27731206
77E2F1_20622854_ChIP-Seq_HELA_Human1.27681971
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27571299
79MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.27240562
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25750226
81RARA_24833708_ChIP-Seq_LIVER_Mouse1.25597535
82* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.24751071
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24502019
84* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23607350
85CTCF_27219007_Chip-Seq_Bcells_Human1.23042108
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22771974
87* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22743668
88MAF_26560356_Chip-Seq_TH2_Human1.22489131
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22439990
90* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21658702
91SPI1_23127762_ChIP-Seq_K562_Human1.19506127
92* CTCF_21964334_Chip-Seq_Bcells_Human1.19406819
93* RARB_24833708_ChIP-Seq_LIVER_Mouse1.19131564
94PHF8_20622854_ChIP-Seq_HELA_Human1.18721980
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18150454
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17983033
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17967441
98* MYB_26560356_Chip-Seq_TH1_Human1.17677196
99STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17561327
100ZNF263_19887448_ChIP-Seq_K562_Human1.16899469
101* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16854191
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16046586
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15983933
104P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15434314
105NCOR1_26117541_ChIP-Seq_K562_Human1.14609396
106AR_21909140_ChIP-Seq_LNCAP_Human1.14388990
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14140186
108STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13966704
109SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13361480
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13282052
111* UBF1/2_26484160_Chip-Seq_HMECs_Human1.12331478
112E2F1_21310950_ChIP-Seq_MCF-7_Human1.11048184
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11033687
114* IRF8_27001747_Chip-Seq_BMDM_Mouse1.11002994
115* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10588168
116* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09178730
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05939320
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05666573
119* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05511028
120IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05497055
121CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05135413
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05103268
123TP53_22127205_ChIP-Seq_IMR90_Human1.05045157
124* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03761269
125FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03718649
126* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03049144
127* ETS1_21867929_ChIP-Seq_TH2_Mouse1.03023959
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01946590
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01904645
130* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01725236
131ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01489601
132HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.01313022
133ELF1_20517297_ChIP-Seq_JURKAT_Human1.01133941
134GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00987010
135MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00777215
136FOXP1_21924763_ChIP-Seq_HESCs_Human0.99451157
137* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99378869
138THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98861183
139* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96917441
140UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96667642
141KDM5A_27292631_Chip-Seq_BREAST_Human0.94354357
142* GABP_19822575_ChIP-Seq_HepG2_Human0.92929260
143* KDM2B_26808549_Chip-Seq_JURKAT_Human0.92791860
144ETS1_20019798_ChIP-Seq_JURKAT_Human0.92248948
145P68_20966046_ChIP-Seq_HELA_Human0.89032615
146TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88884714
147ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88768167
148ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88465284

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.39117619
2MP0005171_absent_coat_pigmentation3.20349399
3MP0010352_gastrointestinal_tract_polyps3.06062296
4MP0008438_abnormal_cutaneous_collagen2.86399204
5MP0005409_darkened_coat_color2.71800341
6MP0003303_peritoneal_inflammation2.59048964
7MP0003453_abnormal_keratinocyte_physiol2.41324234
8MP0003566_abnormal_cell_adhesion2.37511484
9MP0003300_gastrointestinal_ulcer2.31698357
10MP0005076_abnormal_cell_differentiation2.24176257
11MP0005451_abnormal_body_composition2.23934405
12MP0009278_abnormal_bone_marrow2.00951494
13MP0003279_aneurysm1.96672641
14MP0003436_decreased_susceptibility_to1.95929946
15MP0000751_myopathy1.94482579
16MP0006054_spinal_hemorrhage1.89959670
17MP0002396_abnormal_hematopoietic_system1.89117885
18MP0005023_abnormal_wound_healing1.83229585
19MP0000685_abnormal_immune_system1.82052923
20MP0010307_abnormal_tumor_latency1.77051293
21MP0009333_abnormal_splenocyte_physiolog1.72545384
22MP0001835_abnormal_antigen_presentation1.72157502
23MP0003693_abnormal_embryo_hatching1.70012184
24MP0000858_altered_metastatic_potential1.69649285
25MP0004808_abnormal_hematopoietic_stem1.66592774
26MP0005501_abnormal_skin_physiology1.65915687
27MP0005058_abnormal_lysosome_morphology1.65131272
28MP0005174_abnormal_tail_pigmentation1.59556504
29MP0004185_abnormal_adipocyte_glucose1.57663161
30MP0004957_abnormal_blastocyst_morpholog1.56548931
31MP0003111_abnormal_nucleus_morphology1.55545959
32MP0001958_emphysema1.52841044
33MP0003077_abnormal_cell_cycle1.52431411
34MP0003172_abnormal_lysosome_physiology1.50076431
35MP0003091_abnormal_cell_migration1.46441873
36MP0003448_altered_tumor_morphology1.44334760
37MP0001661_extended_life_span1.44328083
38MP0002060_abnormal_skin_morphology1.44318069
39MP0008007_abnormal_cellular_replicative1.43886408
40MP0000733_abnormal_muscle_development1.43188724
41MP0001545_abnormal_hematopoietic_system1.42112749
42MP0005397_hematopoietic_system_phenotyp1.42112749
43MP0001730_embryonic_growth_arrest1.41289408
44MP0005000_abnormal_immune_tolerance1.41151090
45MP0002405_respiratory_system_inflammati1.40377635
46* MP0002452_abnormal_antigen_presenting1.39896175
47MP0000003_abnormal_adipose_tissue1.39103990
48MP0005275_abnormal_skin_tensile1.38839648
49MP0000490_abnormal_crypts_of1.38725246
50* MP0002398_abnormal_bone_marrow1.37930442
51MP0001849_ear_inflammation1.36834661
52MP0005387_immune_system_phenotype1.36672490
53MP0001790_abnormal_immune_system1.36672490
54MP0005330_cardiomyopathy1.36025900
55MP0001800_abnormal_humoral_immune1.35807211
56MP0004947_skin_inflammation1.34886146
57MP0002877_abnormal_melanocyte_morpholog1.34452033
58MP0000350_abnormal_cell_proliferation1.32081656
59MP0005083_abnormal_biliary_tract1.31004872
60MP0001873_stomach_inflammation1.28123855
61MP0003763_abnormal_thymus_physiology1.28119986
62* MP0002420_abnormal_adaptive_immunity1.27443567
63MP0003191_abnormal_cellular_cholesterol1.27240222
64MP0005257_abnormal_intraocular_pressure1.27101819
65* MP0001819_abnormal_immune_cell1.27097985
66MP0008260_abnormal_autophagy1.25399024
67MP0001533_abnormal_skeleton_physiology1.23448013
68MP0006082_CNS_inflammation1.22471730
69MP0002796_impaired_skin_barrier1.22466406
70* MP0002722_abnormal_immune_system1.21040761
71MP0001348_abnormal_lacrimal_gland1.19880934
72MP0005464_abnormal_platelet_physiology1.19004828
73MP0010030_abnormal_orbit_morphology1.18968330
74MP0002933_joint_inflammation1.18718448
75MP0000678_abnormal_parathyroid_gland1.17367217
76* MP0002723_abnormal_immune_serum1.16279036
77MP0002419_abnormal_innate_immunity1.16163735
78* MP0000689_abnormal_spleen_morphology1.15932679
79MP0003329_amyloid_beta_deposits1.15274326
80MP0005025_abnormal_response_to1.14888934
81* MP0000716_abnormal_immune_system1.14463321
82MP0004510_myositis1.13107208
83MP0010094_abnormal_chromosome_stability1.12595257
84* MP0002429_abnormal_blood_cell1.09804970
85MP0004197_abnormal_fetal_growth/weight/1.09269032
86* MP0000703_abnormal_thymus_morphology1.09219915
87MP0002254_reproductive_system_inflammat1.08850772
88MP0005375_adipose_tissue_phenotype1.08794920
89MP0004858_abnormal_nervous_system1.07510828
90MP0002998_abnormal_bone_remodeling1.07210100
91MP0001915_intracranial_hemorrhage1.06759340
92MP0005671_abnormal_response_to1.06636411
93MP0005623_abnormal_meninges_morphology1.06273886
94MP0009785_altered_susceptibility_to1.05345032
95MP0010155_abnormal_intestine_physiology1.05029902
96MP0002019_abnormal_tumor_incidence1.04179855
97MP0004272_abnormal_basement_membrane1.04123420
98MP0000747_muscle_weakness1.02228419
99MP0001697_abnormal_embryo_size1.02065626
100MP0004381_abnormal_hair_follicle1.01661838
101MP0003984_embryonic_growth_retardation1.00684728
102MP0002086_abnormal_extraembryonic_tissu0.99903442
103MP0005666_abnormal_adipose_tissue0.98832971
104MP0002088_abnormal_embryonic_growth/wei0.98479942
105* MP0002080_prenatal_lethality0.98472111
106MP0000343_altered_response_to0.98269269
107MP0001986_abnormal_taste_sensitivity0.96892440
108MP0000015_abnormal_ear_pigmentation0.96362885
109MP0009931_abnormal_skin_appearance0.96028699
110MP0002166_altered_tumor_susceptibility0.95819988
111MP0002148_abnormal_hypersensitivity_rea0.94616448
112MP0005380_embryogenesis_phenotype0.94135480
113MP0001672_abnormal_embryogenesis/_devel0.94135480
114MP0004233_abnormal_muscle_weight0.93666743
115MP0005423_abnormal_somatic_nervous0.93502100
116MP0010234_abnormal_vibrissa_follicle0.91559137
117MP0000767_abnormal_smooth_muscle0.91342477
118MP0005503_abnormal_tendon_morphology0.89529893
119MP0009840_abnormal_foam_cell0.89428691
120MP0001216_abnormal_epidermal_layer0.89423402
121MP0002089_abnormal_postnatal_growth/wei0.89271047
122MP0000013_abnormal_adipose_tissue0.88629640
123MP0005390_skeleton_phenotype0.87737746
124MP0003123_paternal_imprinting0.86072003
125MP0000313_abnormal_cell_death0.86036415
126MP0000750_abnormal_muscle_regeneration0.85661946
127MP0009384_cardiac_valve_regurgitation0.85337777
128* MP0001845_abnormal_inflammatory_respons0.84397465
129MP0005621_abnormal_cell_physiology0.83686335
130MP0008961_abnormal_basal_metabolism0.83028676
131MP0008932_abnormal_embryonic_tissue0.82998424
132MP0000465_gastrointestinal_hemorrhage0.82886852
133MP0003075_altered_response_to0.82802335
134MP0002925_abnormal_cardiovascular_devel0.82798643
135MP0002084_abnormal_developmental_patter0.81517359
136MP0010368_abnormal_lymphatic_system0.80041222
137MP0000604_amyloidosis0.79365892
138MP0002896_abnormal_bone_mineralization0.78904831
139MP0002249_abnormal_larynx_morphology0.77208117
140MP0000759_abnormal_skeletal_muscle0.76549177
141MP0001542_abnormal_bone_strength0.76316002
142MP0008874_decreased_physiological_sensi0.69633082
143MP0001243_abnormal_dermal_layer0.65929754
144MP0001502_abnormal_circadian_rhythm0.63464722

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.21025397
2Testicular atrophy (HP:0000029)4.18859755
3Hemorrhage of the eye (HP:0011885)4.16582683
4Cerebral aneurysm (HP:0004944)3.55896374
5Annular pancreas (HP:0001734)3.43257831
6Premature rupture of membranes (HP:0001788)3.12158640
7Turricephaly (HP:0000262)3.00134453
8Hyperacusis (HP:0010780)2.95900198
9Cervical subluxation (HP:0003308)2.94529136
10Shallow orbits (HP:0000586)2.88881349
11Increased density of long bones (HP:0006392)2.78754415
12Joint hemorrhage (HP:0005261)2.73729111
13Ankle contracture (HP:0006466)2.71795180
14Poikiloderma (HP:0001029)2.66209645
15Vertebral compression fractures (HP:0002953)2.65756034
16Dilatation of the ascending aorta (HP:0005111)2.63564158
17Abnormality of the intrinsic pathway (HP:0010989)2.58069957
18Achilles tendon contracture (HP:0001771)2.54403639
19Aortic aneurysm (HP:0004942)2.54201706
20Peritonitis (HP:0002586)2.51263068
21Dyschromatopsia (HP:0007641)2.48277190
22Eczematoid dermatitis (HP:0000976)2.46551663
23Elevated erythrocyte sedimentation rate (HP:0003565)2.41468706
24Hand muscle atrophy (HP:0009130)2.41453479
25Genu recurvatum (HP:0002816)2.40743667
26Upper limb amyotrophy (HP:0009129)2.40621886
27Distal upper limb amyotrophy (HP:0007149)2.40621886
28Increased cerebral lipofuscin (HP:0011813)2.38957748
29Bowed forearm bones (HP:0003956)2.38913324
30Bowing of the arm (HP:0006488)2.38913324
31Cellulitis (HP:0100658)2.37557873
32Akinesia (HP:0002304)2.35961895
33Interstitial pulmonary disease (HP:0006530)2.35587286
34Bladder diverticulum (HP:0000015)2.29497732
35Distal lower limb amyotrophy (HP:0008944)2.29407304
36Rib fusion (HP:0000902)2.28021313
37Intestinal fistula (HP:0100819)2.27108146
38Thin ribs (HP:0000883)2.24815872
39Abnormality of the Achilles tendon (HP:0005109)2.22469899
40Selective tooth agenesis (HP:0001592)2.21686028
41Aortic dissection (HP:0002647)2.21024528
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.20837659
43Short 4th metacarpal (HP:0010044)2.20837659
44Atrioventricular block (HP:0001678)2.19227221
45Zonular cataract (HP:0010920)2.17439886
46Vaginal fistula (HP:0004320)2.13828835
47Dysostosis multiplex (HP:0000943)2.12974993
48Myopathic facies (HP:0002058)2.11142973
49Coronal craniosynostosis (HP:0004440)2.10090751
50Recurrent abscess formation (HP:0002722)2.09674493
51Long palpebral fissure (HP:0000637)2.09346724
52Bowel diverticulosis (HP:0005222)2.08776957
53Ulnar bowing (HP:0003031)2.08320971
54Distal lower limb muscle weakness (HP:0009053)2.07516041
55Squamous cell carcinoma (HP:0002860)2.07373642
56Mucopolysacchariduria (HP:0008155)2.07255873
57Urinary glycosaminoglycan excretion (HP:0003541)2.07255873
58Thin bony cortex (HP:0002753)2.06797344
59Spinal rigidity (HP:0003306)2.04110797
60Choroideremia (HP:0001139)2.04109800
61Thrombocytosis (HP:0001894)2.04102672
62Abnormality of the anterior horn cell (HP:0006802)2.00537219
63Degeneration of anterior horn cells (HP:0002398)2.00537219
64Facial hemangioma (HP:0000329)2.00136060
65Abnormality of liposaccharide metabolism (HP:0010968)2.00112566
66Abnormality of glycosphingolipid metabolism (HP:0004343)2.00112566
67Abnormality of glycolipid metabolism (HP:0010969)2.00112566
68Rectovaginal fistula (HP:0000143)1.99750792
69Rectal fistula (HP:0100590)1.99750792
70Osteolytic defects of the hand bones (HP:0009699)1.97753413
71Osteolytic defects of the phalanges of the hand (HP:0009771)1.97753413
72Facial diplegia (HP:0001349)1.97030727
73Delayed epiphyseal ossification (HP:0002663)1.96800460
74Popliteal pterygium (HP:0009756)1.96352408
75Aplasia of the musculature (HP:0100854)1.95332786
76Arterial tortuosity (HP:0005116)1.95326928
77Abnormality of the peritoneum (HP:0002585)1.95060886
78Vascular tortuosity (HP:0004948)1.95033951
79Bicuspid aortic valve (HP:0001647)1.94645147
80Broad face (HP:0000283)1.94525986
81Mitral valve prolapse (HP:0001634)1.93998727
82Abnormality of the calcaneus (HP:0008364)1.93211397
83Fragile skin (HP:0001030)1.93004925
84Obstructive sleep apnea (HP:0002870)1.92992434
85Easy fatigability (HP:0003388)1.92307952
86Mitral regurgitation (HP:0001653)1.89808813
87Autoimmune thrombocytopenia (HP:0001973)1.87484282
88Abnormality of the acetabulum (HP:0003170)1.86503653
89Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.86345070
90Myositis (HP:0100614)1.86300190
91Abnormality of the nasal mucosa (HP:0000433)1.85140553
92Stridor (HP:0010307)1.84645698
93Wrist flexion contracture (HP:0001239)1.84094026
94Trismus (HP:0000211)1.84026595
95Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83723489
96Abnormality of polysaccharide metabolism (HP:0011012)1.83723489
97Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83723489
98Aneurysm (HP:0002617)1.83636628
99Increased neuronal autofluorescent lipopigment (HP:0002074)1.80188826
100Elbow flexion contracture (HP:0002987)1.79747723
101Abnormality of the common coagulation pathway (HP:0010990)1.79500312
102Hyperparathyroidism (HP:0000843)1.79442385
103Renal duplication (HP:0000075)1.79320809
104Dislocated radial head (HP:0003083)1.78633893
105Chronic otitis media (HP:0000389)1.77836528
106Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76680510
107Blue sclerae (HP:0000592)1.76670020
108Abnormality of the costochondral junction (HP:0000919)1.75352775
109Prolonged partial thromboplastin time (HP:0003645)1.74874635
110Recurrent viral infections (HP:0004429)1.74523627
111Joint stiffness (HP:0001387)1.74138580
112Camptodactyly of toe (HP:0001836)1.74054221
113Broad palm (HP:0001169)1.73605010
114Hematochezia (HP:0002573)1.73048234
115Striae distensae (HP:0001065)1.72997614
116Anteriorly placed anus (HP:0001545)1.72892958
117Emphysema (HP:0002097)1.72796700
118Hypercortisolism (HP:0001578)1.72727675
119Nasal polyposis (HP:0100582)1.72672820
120Deviation of the hallux (HP:0010051)1.72611409
121Hallux valgus (HP:0001822)1.71410107
122High pitched voice (HP:0001620)1.71160083
123Wormian bones (HP:0002645)1.70823606
124Atrophic scars (HP:0001075)1.69484723
125Spinal cord lesions (HP:0100561)1.69479081
126Syringomyelia (HP:0003396)1.69479081
127Persistence of primary teeth (HP:0006335)1.68268664
128Hypertensive crisis (HP:0100735)1.68208482
129Soft skin (HP:0000977)1.67970155
130Generalized amyotrophy (HP:0003700)1.67810151
131Hypertriglyceridemia (HP:0002155)1.67165396
132Broad metatarsal (HP:0001783)1.66674428
133Increased connective tissue (HP:0009025)1.66080537
134Congenital hip dislocation (HP:0001374)1.66060119
135Biconcave vertebral bodies (HP:0004586)1.66001736
136Cutaneous melanoma (HP:0012056)1.65917787
137Frequent falls (HP:0002359)1.65467817
138Increased variability in muscle fiber diameter (HP:0003557)1.65235933
139Gastrointestinal dysmotility (HP:0002579)1.64916997
140Diminished motivation (HP:0000745)1.64778656
141Mildly elevated creatine phosphokinase (HP:0008180)1.64288188
142Radial bowing (HP:0002986)1.64056336
143Abnormality of the radial head (HP:0003995)1.63897462
144Joint contractures involving the joints of the feet (HP:0100492)1.63588560
145Flexion contracture of toe (HP:0005830)1.63588560
146Asymmetry of the thorax (HP:0001555)1.63018117
147Centrally nucleated skeletal muscle fibers (HP:0003687)1.62711057
148Deviation of the thumb (HP:0009603)1.62511346
149Recurrent fungal infections (HP:0002841)1.62102052
150Slender long bone (HP:0003100)1.61994604
151Vertebral hypoplasia (HP:0008417)1.59616324
152Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.59616324
153Asymmetric septal hypertrophy (HP:0001670)1.59141632
154Cholelithiasis (HP:0001081)1.58995915
155Spinal muscular atrophy (HP:0007269)1.57417720
156Severe short stature (HP:0003510)1.57414845
157Abnormality of macrophages (HP:0004311)1.56532188
158Disproportionate tall stature (HP:0001519)1.56199904
159Thoracolumbar scoliosis (HP:0002944)1.56122958
160Apathy (HP:0000741)1.55304418
161Verrucae (HP:0200043)1.55205763
162Papilloma (HP:0012740)1.55205763
163Slender build (HP:0001533)1.54929313
164Recurrent bacterial skin infections (HP:0005406)1.53977857

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.61904361
2PKN23.22425481
3EEF2K3.18952448
4PRPF4B3.14677521
5ERN13.02194594
6MAPK152.96077063
7SMG12.91972865
8TESK22.82625253
9IRAK32.72654351
10MAP3K102.56974542
11MAP4K12.52148577
12TESK12.39649971
13LRRK22.20591010
14STK102.17881439
15SCYL22.12424196
16TTN1.88020789
17PAK41.83699045
18RPS6KA41.73720681
19PIM21.62806335
20CDK121.61660123
21KDR1.58355442
22PTK61.51156461
23LIMK11.50161955
24BLK1.50094780
25ZAP701.49540938
26BMX1.41626687
27TBK11.39887921
28ARAF1.38651058
29PRKD21.36838005
30MAP3K81.31294200
31JAK31.29748693
32NEK21.27446635
33RIPK11.26701311
34NME21.22718975
35SIK31.19221174
36PDGFRA1.18896704
37CDC71.18043629
38BUB11.17532250
39MAP3K131.15796989
40PDPK11.15541623
41MAP2K31.15184840
42MAP3K111.14708011
43ALK1.12080348
44PRKD31.11558920
45NEK11.11389709
46TAOK11.09680229
47TGFBR11.09047104
48ILK1.07492087
49CDC42BPA1.05774956
50IRAK21.05302084
51TYK21.02254359
52EPHB11.01735621
53TGFBR20.97352106
54PASK0.96531757
55PAK20.95084984
56LATS20.94719033
57MAP3K140.94592246
58RIPK40.94323677
59PTK20.93525821
60MST1R0.90721862
61IRAK40.89032360
62KIT0.88693877
63RPS6KB20.88658319
64FLT30.87178741
65CSF1R0.84031978
66MTOR0.83396500
67CDK60.83015594
68BTK0.82891492
69GRK60.81746087
70MAP3K10.81416670
71MARK20.80386891
72SIK10.80047834
73MOS0.79915616
74DDR20.79520355
75MAPK110.78699414
76MAPKAPK30.76856163
77NTRK10.75338015
78KSR20.72720501
79CDK40.72590383
80PIM10.69002385
81ICK0.68597765
82MUSK0.67133204
83CDK70.64623208
84CSK0.64562837
85HIPK20.64532153
86BRAF0.64463627
87ITK0.63636026
88HCK0.63485925
89CHUK0.63269043
90EPHB20.63150485
91MAPKAPK20.59631612
92FGFR40.59112509
93JAK10.58572843
94TSSK60.57522835
95CDK11A0.56942666
96DMPK0.56626675
97EIF2AK10.56183311
98CDK150.55876701
99MARK30.54697597
100DYRK1B0.53057097
101LMTK20.53053685
102* PAK10.52898717
103MATK0.51917412
104FGFR10.50609610
105SYK0.50404510
106MAP3K30.49932735
107NEK90.49147081
108CDK180.49056729
109RET0.47968324
110LCK0.47461528
111PDK10.46431515
112MAP2K20.46066260
113PDGFRB0.44536496
114RPS6KA20.44057881
115MAPK120.43976306
116WNK40.43973041
117STK380.43874407
118PRKG20.42922663
119EPHA20.42644952
120CDK140.42290284
121MELK0.42027121
122EPHA30.41487999
123CLK10.40721533
124SIK20.40048699
125IKBKB0.39791624
126CAMKK10.39295714
127AURKB0.39031459
128PRKD10.38952000
129ATR0.38057396
130AURKA0.37055051
131RPS6KA60.37001979
132IKBKE0.36108966
133ABL20.35853875
134BRSK10.34615079
135WEE10.34272570
136TAOK20.34150001
137DAPK30.32931113
138PRKCH0.32199203
139RPS6KC10.31831412
140RPS6KL10.31831412

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041222.38257373
2DNA replication_Homo sapiens_hsa030302.17375221
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.15126720
4Fructose and mannose metabolism_Homo sapiens_hsa000511.93252407
5Shigellosis_Homo sapiens_hsa051311.87901362
6Leishmaniasis_Homo sapiens_hsa051401.87787769
7Chronic myeloid leukemia_Homo sapiens_hsa052201.87501739
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.76850319
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73762611
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.72425382
11Antigen processing and presentation_Homo sapiens_hsa046121.71768920
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.63076363
13Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.59426662
14Viral myocarditis_Homo sapiens_hsa054161.57495290
15B cell receptor signaling pathway_Homo sapiens_hsa046621.51237895
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.50029279
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.49618769
18Apoptosis_Homo sapiens_hsa042101.47542673
19Legionellosis_Homo sapiens_hsa051341.44186870
20Base excision repair_Homo sapiens_hsa034101.41940911
21Osteoclast differentiation_Homo sapiens_hsa043801.41397420
22Small cell lung cancer_Homo sapiens_hsa052221.37388540
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.37126358
24Mismatch repair_Homo sapiens_hsa034301.36258971
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35933322
26Toxoplasmosis_Homo sapiens_hsa051451.35867275
27Cell cycle_Homo sapiens_hsa041101.35798307
28Prion diseases_Homo sapiens_hsa050201.35482486
29Acute myeloid leukemia_Homo sapiens_hsa052211.35267699
30Pancreatic cancer_Homo sapiens_hsa052121.31969406
31p53 signaling pathway_Homo sapiens_hsa041151.29182104
32Proteoglycans in cancer_Homo sapiens_hsa052051.27759325
33Bladder cancer_Homo sapiens_hsa052191.27301533
34Lysosome_Homo sapiens_hsa041421.26291300
35Measles_Homo sapiens_hsa051621.24011266
36HTLV-I infection_Homo sapiens_hsa051661.23470903
37RNA transport_Homo sapiens_hsa030131.22865271
38Spliceosome_Homo sapiens_hsa030401.21394196
39* Neurotrophin signaling pathway_Homo sapiens_hsa047221.20882235
40Hepatitis B_Homo sapiens_hsa051611.20796584
41Primary immunodeficiency_Homo sapiens_hsa053401.20742617
42Colorectal cancer_Homo sapiens_hsa052101.19913612
43Thyroid cancer_Homo sapiens_hsa052161.18459164
44Focal adhesion_Homo sapiens_hsa045101.17963640
45Sphingolipid metabolism_Homo sapiens_hsa006001.17789063
46Salmonella infection_Homo sapiens_hsa051321.17780243
47Adherens junction_Homo sapiens_hsa045201.17343423
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.15835911
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15759635
50VEGF signaling pathway_Homo sapiens_hsa043701.15201783
51Viral carcinogenesis_Homo sapiens_hsa052031.14680973
52MicroRNAs in cancer_Homo sapiens_hsa052061.13733534
53Tuberculosis_Homo sapiens_hsa051521.10206497
54Pertussis_Homo sapiens_hsa051331.10050637
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09976656
56Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09929226
57Galactose metabolism_Homo sapiens_hsa000521.08928760
58Epstein-Barr virus infection_Homo sapiens_hsa051691.08865683
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07783482
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03444251
61Central carbon metabolism in cancer_Homo sapiens_hsa052301.01524878
62T cell receptor signaling pathway_Homo sapiens_hsa046600.99969476
63Non-small cell lung cancer_Homo sapiens_hsa052230.99511638
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99264506
65TNF signaling pathway_Homo sapiens_hsa046680.99027781
66HIF-1 signaling pathway_Homo sapiens_hsa040660.97295013
67Herpes simplex infection_Homo sapiens_hsa051680.97039014
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96626603
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95273173
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.94653481
71mTOR signaling pathway_Homo sapiens_hsa041500.94009604
72One carbon pool by folate_Homo sapiens_hsa006700.93321414
73Pentose phosphate pathway_Homo sapiens_hsa000300.93046900
74Influenza A_Homo sapiens_hsa051640.92804444
75Notch signaling pathway_Homo sapiens_hsa043300.92358254
76Endometrial cancer_Homo sapiens_hsa052130.92107519
77Amoebiasis_Homo sapiens_hsa051460.90353084
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89163373
79Platelet activation_Homo sapiens_hsa046110.88321231
80Malaria_Homo sapiens_hsa051440.86986275
81Endocytosis_Homo sapiens_hsa041440.85271828
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84518196
83Other glycan degradation_Homo sapiens_hsa005110.83608987
84Hematopoietic cell lineage_Homo sapiens_hsa046400.82971111
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.82544180
86Glioma_Homo sapiens_hsa052140.82074665
87Chemokine signaling pathway_Homo sapiens_hsa040620.77108626
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.76918032
89ECM-receptor interaction_Homo sapiens_hsa045120.76502554
90Proteasome_Homo sapiens_hsa030500.76084686
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.75844884
92Inositol phosphate metabolism_Homo sapiens_hsa005620.75532012
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75360951
94Insulin signaling pathway_Homo sapiens_hsa049100.75228206
95Nucleotide excision repair_Homo sapiens_hsa034200.75059550
96GnRH signaling pathway_Homo sapiens_hsa049120.74473519
97Hippo signaling pathway_Homo sapiens_hsa043900.74374990
98Renal cell carcinoma_Homo sapiens_hsa052110.73497646
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72880655
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71817580
101Prolactin signaling pathway_Homo sapiens_hsa049170.71421907
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71351238
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.70873548
104Phagosome_Homo sapiens_hsa041450.70254193
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69415220
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69090749
107Vibrio cholerae infection_Homo sapiens_hsa051100.69060884
108ErbB signaling pathway_Homo sapiens_hsa040120.69054636
109Pathways in cancer_Homo sapiens_hsa052000.68693149
110Insulin resistance_Homo sapiens_hsa049310.68250410
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.67958020
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66567044
113N-Glycan biosynthesis_Homo sapiens_hsa005100.66203452
114Estrogen signaling pathway_Homo sapiens_hsa049150.65233833
115Prostate cancer_Homo sapiens_hsa052150.64109680
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63847354
117Ribosome_Homo sapiens_hsa030100.62289802
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61920843
119TGF-beta signaling pathway_Homo sapiens_hsa043500.61311937
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60318947
121Biosynthesis of amino acids_Homo sapiens_hsa012300.59289313
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57314079
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56792828
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56266573
125Hepatitis C_Homo sapiens_hsa051600.55693822
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54366478
127mRNA surveillance pathway_Homo sapiens_hsa030150.54116563
128AMPK signaling pathway_Homo sapiens_hsa041520.53768705
129Rap1 signaling pathway_Homo sapiens_hsa040150.53246947
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52120930
131Melanogenesis_Homo sapiens_hsa049160.50378479
132Melanoma_Homo sapiens_hsa052180.49292217
133Gap junction_Homo sapiens_hsa045400.46100262

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