ARHGEF10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in labyrinthine layer morphogenesis (GO:0060670)8.66617852
2axon ensheathment in central nervous system (GO:0032291)8.62723070
3central nervous system myelination (GO:0022010)8.62723070
4anterior/posterior axis specification, embryo (GO:0008595)5.73435873
5lung-associated mesenchyme development (GO:0060484)5.56686959
6* ensheathment of neurons (GO:0007272)5.35801168
7* axon ensheathment (GO:0008366)5.35801168
8* myelination (GO:0042552)5.29061185
9positive regulation of inositol phosphate biosynthetic process (GO:0060732)5.24000181
10negative regulation of telomerase activity (GO:0051974)5.07579705
11lymphangiogenesis (GO:0001946)4.76557282
12regulation of tight junction assembly (GO:2000810)4.57357259
13myelin maintenance (GO:0043217)4.30845885
14regulation of cell proliferation involved in kidney development (GO:1901722)4.22805863
15prostate gland growth (GO:0060736)4.20296636
16negative regulation of Rho protein signal transduction (GO:0035024)4.14590528
17peptidyl-tyrosine autophosphorylation (GO:0038083)4.11305194
18synapsis (GO:0007129)3.93402679
19inner cell mass cell proliferation (GO:0001833)3.87241097
20L-amino acid import (GO:0043092)3.77077105
21somite development (GO:0061053)3.76435680
22regulation of telomerase activity (GO:0051972)3.74650242
23white fat cell differentiation (GO:0050872)3.68815895
24artery development (GO:0060840)3.66828829
25cell differentiation involved in embryonic placenta development (GO:0060706)3.66437443
26ventricular septum development (GO:0003281)3.65375257
27positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.63470621
28cell proliferation in forebrain (GO:0021846)3.59165439
29sulfation (GO:0051923)3.58925866
30fatty acid elongation (GO:0030497)3.58406718
31embryonic camera-type eye development (GO:0031076)3.56443112
32neuronal ion channel clustering (GO:0045161)3.56385924
33negative regulation of DNA biosynthetic process (GO:2000279)3.52749700
34astrocyte development (GO:0014002)3.52460205
35spinal cord development (GO:0021510)3.51959036
36negative regulation of protein localization to cell surface (GO:2000009)3.47545708
37creatine metabolic process (GO:0006600)3.45238662
38oligodendrocyte differentiation (GO:0048709)3.44846383
39organ growth (GO:0035265)3.41309104
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.39235190
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.39235190
42NADH dehydrogenase complex assembly (GO:0010257)3.39235190
43negative regulation of neurotransmitter secretion (GO:0046929)3.39101164
44gland morphogenesis (GO:0022612)3.32290578
45glycine transport (GO:0015816)3.28412793
46regulation of hippo signaling (GO:0035330)3.27242893
47apical protein localization (GO:0045176)3.27043685
48serine family amino acid catabolic process (GO:0009071)3.26518818
49mitochondrion morphogenesis (GO:0070584)3.25512617
50import into cell (GO:0098657)3.25193496
51regulation of mesoderm development (GO:2000380)3.24306753
52asymmetric protein localization (GO:0008105)3.24250665
53long-chain fatty acid biosynthetic process (GO:0042759)3.24232544
54cytoskeletal anchoring at plasma membrane (GO:0007016)3.23334413
55* myelination in peripheral nervous system (GO:0022011)3.20423705
56* peripheral nervous system axon ensheathment (GO:0032292)3.20423705
57positive regulation of fatty acid oxidation (GO:0046321)3.18442284
58synaptic vesicle maturation (GO:0016188)3.18382103
59positive regulation of mitochondrial fission (GO:0090141)3.18332149
60negative regulation of kidney development (GO:0090185)3.13909457
61regulation of inositol phosphate biosynthetic process (GO:0010919)3.09637008
62response to caffeine (GO:0031000)3.07910827
63eye photoreceptor cell differentiation (GO:0001754)3.07082247
64photoreceptor cell differentiation (GO:0046530)3.07082247
65presynaptic membrane organization (GO:0097090)3.06812014
66negative regulation of neurotransmitter transport (GO:0051589)3.04742071
67negative regulation of synaptic transmission, GABAergic (GO:0032229)3.02277117
68membrane tubulation (GO:0097320)2.96010571
69negative regulation of cardiac muscle tissue development (GO:0055026)2.95955715
70nerve growth factor signaling pathway (GO:0038180)2.95835804
71lateral sprouting from an epithelium (GO:0060601)2.95498330
72neuronal action potential propagation (GO:0019227)2.93763062
73regulation of gene silencing by RNA (GO:0060966)2.93114854
74regulation of posttranscriptional gene silencing (GO:0060147)2.93114854
75regulation of gene silencing by miRNA (GO:0060964)2.93114854
763-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.92690378
77purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.92690378
78regulation of sequestering of triglyceride (GO:0010889)2.91023152
79amino acid import (GO:0043090)2.87277014
80virion attachment to host cell (GO:0019062)2.86097060
81adhesion of symbiont to host cell (GO:0044650)2.86097060
82DNA replication checkpoint (GO:0000076)2.84241200
83regulation of collateral sprouting (GO:0048670)2.83483106
84locomotory exploration behavior (GO:0035641)2.83047621
85protein localization to endosome (GO:0036010)2.82246426
86cardiac septum development (GO:0003279)2.78528035
87adult walking behavior (GO:0007628)2.77553286
88negative regulation of axonogenesis (GO:0050771)2.77222658
89mitochondrial fusion (GO:0008053)2.77051510
90DNA deamination (GO:0045006)2.75342141
91negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.72710515
92regulation of energy homeostasis (GO:2000505)2.71058095
93positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.69351756
94response to methylmercury (GO:0051597)2.69245864
95paraxial mesoderm development (GO:0048339)2.68234561
96outer ear morphogenesis (GO:0042473)2.68144560
97axonal fasciculation (GO:0007413)2.66984303
98transmission of nerve impulse (GO:0019226)2.64725974
99chromosome organization involved in meiosis (GO:0070192)2.64321345
100neuron remodeling (GO:0016322)2.64224737
101glycine metabolic process (GO:0006544)2.61782893
102ovulation cycle (GO:0042698)2.61546664
103neuron recognition (GO:0008038)2.59231972
104substrate-independent telencephalic tangential migration (GO:0021826)2.58863148
105substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.58863148
106negative regulation of axon extension (GO:0030517)2.58716560
107semaphorin-plexin signaling pathway (GO:0071526)2.56339037
108establishment of mitochondrion localization (GO:0051654)2.55407434
109dendritic spine morphogenesis (GO:0060997)2.55265619
110negative regulation of JUN kinase activity (GO:0043508)2.54841253
111negative regulation of heart growth (GO:0061117)2.54195800
112negative regulation of cardiac muscle tissue growth (GO:0055022)2.54195800
113dendrite morphogenesis (GO:0048813)2.53643038
114potassium ion import (GO:0010107)2.51574056
115layer formation in cerebral cortex (GO:0021819)2.51186522
116negative regulation of astrocyte differentiation (GO:0048712)2.51107830
117cellular response to epinephrine stimulus (GO:0071872)2.50779440
118regulation of nuclear cell cycle DNA replication (GO:0033262)2.49984841
119mesenchymal-epithelial cell signaling (GO:0060638)2.49855068
120protein complex biogenesis (GO:0070271)2.49250411
121cellular response to lithium ion (GO:0071285)2.47122156
122substantia nigra development (GO:0021762)2.45820498
123peristalsis (GO:0030432)2.45451316
124camera-type eye morphogenesis (GO:0048593)2.45236141
125lung morphogenesis (GO:0060425)2.44817213
126protein K11-linked deubiquitination (GO:0035871)2.43713916
127branching involved in salivary gland morphogenesis (GO:0060445)2.43375863
128dorsal/ventral axis specification (GO:0009950)2.43190036
129renal system development (GO:0072001)2.43130756
130regulation of glomerulus development (GO:0090192)2.42897675
131organ induction (GO:0001759)2.41324387
132cellular response to catecholamine stimulus (GO:0071870)2.39684453
133cellular response to monoamine stimulus (GO:0071868)2.39684453
134positive regulation of oligodendrocyte differentiation (GO:0048714)2.39630918
135response to lipoprotein particle (GO:0055094)2.39071697
136presynaptic membrane assembly (GO:0097105)2.38686036
137cerebral cortex radially oriented cell migration (GO:0021799)2.38088253
138regulation of voltage-gated calcium channel activity (GO:1901385)2.37985449
139replication fork processing (GO:0031297)2.37415726
140mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.37199248
141enteric nervous system development (GO:0048484)2.37142475
142pituitary gland development (GO:0021983)2.36070787
143replicative senescence (GO:0090399)2.35911967
144response to BMP (GO:0071772)2.35537299
145cellular response to BMP stimulus (GO:0071773)2.35537299
146calcium-mediated signaling using intracellular calcium source (GO:0035584)2.34575558
147sodium ion export (GO:0071436)2.33984611
148dermatan sulfate biosynthetic process (GO:0030208)2.33971430
149regulation of mitochondrial fission (GO:0090140)2.33882887
150positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.33322729
151organ formation (GO:0048645)2.33311020
152positive regulation of glomerulus development (GO:0090193)2.32567649
153mitochondrial respiratory chain complex assembly (GO:0033108)2.32477472
154membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.32438191
155otic vesicle formation (GO:0030916)2.32064446
156regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.31719470
157establishment of nucleus localization (GO:0040023)2.31707735
158positive regulation of action potential (GO:0045760)2.31489553
159cell migration involved in sprouting angiogenesis (GO:0002042)2.30595477
160cell migration involved in gastrulation (GO:0042074)2.29630434
161neuromuscular junction development (GO:0007528)2.29272671
162cerebellar granule cell differentiation (GO:0021707)2.28792654
163positive regulation of potassium ion transport (GO:0043268)2.28455189
164cortical actin cytoskeleton organization (GO:0030866)2.28425399
165thalamus development (GO:0021794)2.28066825
166peripheral nervous system development (GO:0007422)2.27798602
167positive regulation of neurological system process (GO:0031646)2.27581459
168embryonic axis specification (GO:0000578)2.27477586
169TOR signaling (GO:0031929)2.27118091
170negative regulation of axon extension involved in axon guidance (GO:0048843)2.25137235
171DNA double-strand break processing (GO:0000729)2.24802980
172glomerular filtration (GO:0003094)2.24714626
173response to epinephrine (GO:0071871)2.24387449
174neuromuscular process controlling balance (GO:0050885)2.24321957
175neuron cell-cell adhesion (GO:0007158)2.24239776
176response to catecholamine (GO:0071869)2.23856687
177response to monoamine (GO:0071867)2.23856687
178mating behavior (GO:0007617)2.20283304
179membrane assembly (GO:0071709)2.20089418
180positive regulation of glial cell differentiation (GO:0045687)2.18652036
181response to redox state (GO:0051775)2.17759785
182glycerophospholipid catabolic process (GO:0046475)2.17625852
183positive regulation of gliogenesis (GO:0014015)2.17599918
184regulation of neuronal synaptic plasticity (GO:0048168)2.17062687
185positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.16477386
186potassium ion homeostasis (GO:0055075)2.16373511
187long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.16123053
188renal filtration (GO:0097205)2.15936188
189peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.15831820
190regulation of ARF GTPase activity (GO:0032312)2.15128837
191adhesion of symbiont to host (GO:0044406)2.14895472
192negative regulation of catenin import into nucleus (GO:0035414)2.14747290
193protein palmitoylation (GO:0018345)2.14096173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.71170921
2EZH2_22144423_ChIP-Seq_EOC_Human2.62819914
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61114759
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49037937
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49037937
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45206937
7GBX2_23144817_ChIP-Seq_PC3_Human2.36444333
8FUS_26573619_Chip-Seq_HEK293_Human2.34224039
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.31190748
10DROSHA_22980978_ChIP-Seq_HELA_Human2.28577653
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23166650
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21653221
13POU5F1_16153702_ChIP-ChIP_HESCs_Human2.16171580
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.15154563
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14115396
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.13440716
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.11288269
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09158517
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09031657
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.07498048
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05210445
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04708580
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01502090
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.99179550
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97241700
26ZNF274_21170338_ChIP-Seq_K562_Hela1.96957265
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.95147797
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91177506
29AR_21572438_ChIP-Seq_LNCaP_Human1.86401125
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.85949628
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82424860
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.76952456
33LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74423970
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74276553
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72873188
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72418262
37EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.71870508
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67221352
39MYC_18940864_ChIP-ChIP_HL60_Human1.66355122
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.58042842
41P300_19829295_ChIP-Seq_ESCs_Human1.56471795
42* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55701794
43EWS_26573619_Chip-Seq_HEK293_Human1.55504264
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53792341
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52120444
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52008109
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51942403
48* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.51009278
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48872013
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46734816
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44956557
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43070109
53IRF1_19129219_ChIP-ChIP_H3396_Human1.42610983
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.42107949
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.41110537
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40013871
57SOX2_16153702_ChIP-ChIP_HESCs_Human1.38288562
58RNF2_27304074_Chip-Seq_NSC_Mouse1.37691876
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.36077749
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35238634
61* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.34877974
62E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33282237
63* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.33180108
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32777680
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32192260
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.32167580
67CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30404315
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28525599
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26546350
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26393569
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.24437200
72TP53_18474530_ChIP-ChIP_U2OS_Human1.23322780
73TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.22452144
74VDR_22108803_ChIP-Seq_LS180_Human1.20258080
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19327146
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18236113
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17822023
78SOX9_26525672_Chip-Seq_HEART_Mouse1.17526777
79KDM2B_26808549_Chip-Seq_K562_Human1.16428713
80NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14360010
81NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14360010
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13939565
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.13888397
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13567622
85CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13344473
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13096212
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12627598
88* AHR_22903824_ChIP-Seq_MCF-7_Human1.12579150
89TP53_16413492_ChIP-PET_HCT116_Human1.10972740
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.09778467
91ESR1_20079471_ChIP-ChIP_T-47D_Human1.09694535
92AR_25329375_ChIP-Seq_VCAP_Human1.09577621
93TCF4_23295773_ChIP-Seq_U87_Human1.09536691
94IGF1R_20145208_ChIP-Seq_DFB_Human1.09506445
95AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08330035
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.08261305
97POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07823676
98* ARNT_22903824_ChIP-Seq_MCF-7_Human1.07587503
99TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07345188
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06751903
101ERG_21242973_ChIP-ChIP_JURKAT_Human1.05356396
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05269248
103SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04943449
104TP53_20018659_ChIP-ChIP_R1E_Mouse1.04188859
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03963851
106STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03822597
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02994701
108REST_21632747_ChIP-Seq_MESCs_Mouse1.02491864
109JUN_21703547_ChIP-Seq_K562_Human1.01073854
110PIAS1_25552417_ChIP-Seq_VCAP_Human1.00204698
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99092266
112NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98519724
113ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98213758
114BCAT_22108803_ChIP-Seq_LS180_Human0.97666389
115STAT3_23295773_ChIP-Seq_U87_Human0.97566214
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97226197
117TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97075635
118SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96589271
119SMAD4_21799915_ChIP-Seq_A2780_Human0.95893279
120GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95832383
121SOX2_21211035_ChIP-Seq_LN229_Gbm0.95226585
122P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95115107
123TAF15_26573619_Chip-Seq_HEK293_Human0.95091885
124* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94799853
125OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94692830
126POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94688630
127ER_23166858_ChIP-Seq_MCF-7_Human0.94518551
128GATA2_21666600_ChIP-Seq_HMVEC_Human0.93567440
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93208619
130SMAD4_21741376_ChIP-Seq_EPCs_Human0.92774101
131DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92367378
132KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92283779
133SMAD4_21741376_ChIP-Seq_HESCs_Human0.92207272
134MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91928516
135TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90861789
136CJUN_26792858_Chip-Seq_BT549_Human0.89824115
137* AR_19668381_ChIP-Seq_PC3_Human0.88986633
138REST_18959480_ChIP-ChIP_MESCs_Mouse0.88352529
139TBX20_22080862_ChIP-Seq_HEART_Mouse0.88252897
140TBX20_22328084_ChIP-Seq_HEART_Mouse0.88252897
141PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88194408
142CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87763911
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87479357
144RXR_22108803_ChIP-Seq_LS180_Human0.86880947
145ISL1_27105846_Chip-Seq_CPCs_Mouse0.86520658
146SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86517127
147KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86069363
148IKZF1_21737484_ChIP-ChIP_HCT116_Human0.85975467
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84673175
150NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84670140
151FOXO3_23340844_ChIP-Seq_DLD1_Human0.84542107
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84359111
153SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84161353
154TET1_21490601_ChIP-Seq_MESCs_Mouse0.83756774
155ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82474860
156* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82128768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.40276817
2MP0000920_abnormal_myelination3.98196807
3MP0008438_abnormal_cutaneous_collagen3.32361960
4MP0002653_abnormal_ependyma_morphology3.09113774
5MP0004859_abnormal_synaptic_plasticity3.06272598
6MP0000049_abnormal_middle_ear3.04019396
7MP0005623_abnormal_meninges_morphology2.92906412
8MP0003315_abnormal_perineum_morphology2.88442159
9MP0003880_abnormal_central_pattern2.87675477
10MP0005367_renal/urinary_system_phenotyp2.70935031
11MP0000516_abnormal_urinary_system2.70935031
12MP0001849_ear_inflammation2.66481693
13MP0006292_abnormal_olfactory_placode2.59990811
14MP0003690_abnormal_glial_cell2.59886315
15MP0004270_analgesia2.47865271
16MP0009053_abnormal_anal_canal2.47033004
17MP0003693_abnormal_embryo_hatching2.45246470
18MP0003119_abnormal_digestive_system2.35604803
19MP0004272_abnormal_basement_membrane2.23524320
20MP0004885_abnormal_endolymph2.16687641
21MP0005171_absent_coat_pigmentation2.16178472
22MP0003329_amyloid_beta_deposits2.06433855
23MP0002272_abnormal_nervous_system2.03997503
24MP0001486_abnormal_startle_reflex2.03325924
25MP0001661_extended_life_span2.02983397
26MP0003950_abnormal_plasma_membrane2.02919545
27MP0000751_myopathy2.01750844
28MP0003635_abnormal_synaptic_transmissio1.97263190
29MP0005423_abnormal_somatic_nervous1.96072244
30MP0003634_abnormal_glial_cell1.95879777
31MP0002064_seizures1.89873328
32MP0001299_abnormal_eye_distance/1.79687090
33MP0002160_abnormal_reproductive_system1.75365738
34MP0000778_abnormal_nervous_system1.73035706
35MP0003890_abnormal_embryonic-extraembry1.70397069
36MP0009046_muscle_twitch1.65627662
37MP0005275_abnormal_skin_tensile1.63962375
38MP0009745_abnormal_behavioral_response1.63944160
39MP0008569_lethality_at_weaning1.63811475
40MP0004134_abnormal_chest_morphology1.55538745
41MP0009384_cardiac_valve_regurgitation1.54990887
42MP0002282_abnormal_trachea_morphology1.54951995
43MP0001958_emphysema1.53213875
44MP0005503_abnormal_tendon_morphology1.51120195
45MP0009780_abnormal_chondrocyte_physiolo1.50150699
46MP0004145_abnormal_muscle_electrophysio1.47753593
47MP0000013_abnormal_adipose_tissue1.47452609
48MP0000537_abnormal_urethra_morphology1.45217084
49MP0000747_muscle_weakness1.43194139
50MP0004742_abnormal_vestibular_system1.42340147
51MP0000428_abnormal_craniofacial_morphol1.41855453
52MP0008877_abnormal_DNA_methylation1.40708169
53MP0003942_abnormal_urinary_system1.39502050
54MP0003632_abnormal_nervous_system1.38672657
55MP0000462_abnormal_digestive_system1.37668710
56MP0010678_abnormal_skin_adnexa1.37246963
57MP0000955_abnormal_spinal_cord1.37038577
58MP0005409_darkened_coat_color1.34766609
59MP0004133_heterotaxia1.34471495
60MP0002063_abnormal_learning/memory/cond1.33955625
61MP0002751_abnormal_autonomic_nervous1.32980903
62MP0000003_abnormal_adipose_tissue1.31781384
63MP0002102_abnormal_ear_morphology1.31696922
64MP0005646_abnormal_pituitary_gland1.31105733
65MP0002822_catalepsy1.29233962
66MP0002108_abnormal_muscle_morphology1.28281965
67MP0001485_abnormal_pinna_reflex1.24973825
68MP0003279_aneurysm1.23287827
69MP0002734_abnormal_mechanical_nocicepti1.23018002
70MP0000631_abnormal_neuroendocrine_gland1.21724420
71MP0003936_abnormal_reproductive_system1.21601682
72MP0000383_abnormal_hair_follicle1.21577581
73MP0003941_abnormal_skin_development1.21249399
74MP0001529_abnormal_vocalization1.21179382
75MP0000749_muscle_degeneration1.21084075
76MP0000733_abnormal_muscle_development1.19979931
77MP0003631_nervous_system_phenotype1.18213939
78MP0004036_abnormal_muscle_relaxation1.18149686
79MP0001879_abnormal_lymphatic_vessel1.17465409
80MP0001177_atelectasis1.17095711
81MP0010094_abnormal_chromosome_stability1.16937548
82MP0008789_abnormal_olfactory_epithelium1.16859235
83MP0003633_abnormal_nervous_system1.16085000
84MP0009250_abnormal_appendicular_skeleto1.15704455
85MP0002116_abnormal_craniofacial_bone1.15623857
86MP0005410_abnormal_fertilization1.15097559
87MP0003283_abnormal_digestive_organ1.15041530
88MP0003755_abnormal_palate_morphology1.14818902
89MP0003045_fibrosis1.14609963
90MP0002572_abnormal_emotion/affect_behav1.13854248
91MP0001293_anophthalmia1.13798380
92MP0002882_abnormal_neuron_morphology1.13728183
93MP0001348_abnormal_lacrimal_gland1.12730205
94MP0002697_abnormal_eye_size1.12349150
95MP0003137_abnormal_impulse_conducting1.11473061
96MP0004142_abnormal_muscle_tone1.11385322
97MP0003938_abnormal_ear_development1.10973116
98MP0004130_abnormal_muscle_cell1.10654454
99MP0003385_abnormal_body_wall1.09269499
100MP0010368_abnormal_lymphatic_system1.07171708
101MP0002938_white_spotting1.06614682
102MP0005389_reproductive_system_phenotype1.05929036
103MP0003136_yellow_coat_color1.05134460
104MP0001905_abnormal_dopamine_level1.04870372
105MP0004084_abnormal_cardiac_muscle1.04480710
106MP0002234_abnormal_pharynx_morphology1.04250858
107MP0002066_abnormal_motor_capabilities/c1.03720363
108MP0008932_abnormal_embryonic_tissue1.03492101
109MP0000534_abnormal_ureter_morphology1.02931747
110MP0003567_abnormal_fetal_cardiomyocyte1.01871336
111MP0002295_abnormal_pulmonary_circulatio1.01451067
112MP0002233_abnormal_nose_morphology1.00330259
113MP0002111_abnormal_tail_morphology1.00281925
114MP0001440_abnormal_grooming_behavior0.99264565
115MP0003718_maternal_effect0.98905788
116MP0006138_congestive_heart_failure0.98852134
117MP0002229_neurodegeneration0.97914876
118MP0004087_abnormal_muscle_fiber0.96801008
119MP0004185_abnormal_adipocyte_glucose0.95419859
120MP0001286_abnormal_eye_development0.94717938
121MP0001970_abnormal_pain_threshold0.93978370
122MP0001346_abnormal_lacrimal_gland0.93131141
123MP0002084_abnormal_developmental_patter0.92754215
124MP0003091_abnormal_cell_migration0.91577047
125MP0002067_abnormal_sensory_capabilities0.90258980
126MP0000467_abnormal_esophagus_morphology0.90073993
127MP0005195_abnormal_posterior_eye0.89974308
128MP0000613_abnormal_salivary_gland0.89653641
129MP0002733_abnormal_thermal_nociception0.88639140
130MP0000762_abnormal_tongue_morphology0.88590026
131MP0003937_abnormal_limbs/digits/tail_de0.88459309
132MP0002133_abnormal_respiratory_system0.88153704
133MP0005388_respiratory_system_phenotype0.88153704
134MP0005375_adipose_tissue_phenotype0.88006029
135MP0003861_abnormal_nervous_system0.86926094
136MP0004811_abnormal_neuron_physiology0.85170555
137MP0002249_abnormal_larynx_morphology0.84725056
138MP0001697_abnormal_embryo_size0.84545905
139MP0004924_abnormal_behavior0.83888537
140MP0005386_behavior/neurological_phenoty0.83888537
141MP0002152_abnormal_brain_morphology0.81816547
142MP0010030_abnormal_orbit_morphology0.81813455
143MP0005330_cardiomyopathy0.81316100
144MP0002932_abnormal_joint_morphology0.80164629
145MP0005508_abnormal_skeleton_morphology0.79115515
146MP0004197_abnormal_fetal_growth/weight/0.78712385
147MP0000579_abnormal_nail_morphology0.77849754
148MP0004233_abnormal_muscle_weight0.77719650
149MP0004858_abnormal_nervous_system0.76811728
150MP0004085_abnormal_heartbeat0.76594546
151MP0000759_abnormal_skeletal_muscle0.76512172
152MP0003935_abnormal_craniofacial_develop0.76317119
153MP0001501_abnormal_sleep_pattern0.76070817
154MP0008770_decreased_survivor_rate0.75826732
155MP0005394_taste/olfaction_phenotype0.74913173
156MP0005499_abnormal_olfactory_system0.74913173
157MP0002837_dystrophic_cardiac_calcinosis0.74337599
158MP0002109_abnormal_limb_morphology0.74265518
159MP0002085_abnormal_embryonic_tissue0.73782658
160MP0000432_abnormal_head_morphology0.73033881
161MP0006072_abnormal_retinal_apoptosis0.71174192
162MP0005257_abnormal_intraocular_pressure0.70939015
163MP0002254_reproductive_system_inflammat0.70884948
164MP0004957_abnormal_blastocyst_morpholog0.69536751
165MP0001270_distended_abdomen0.66473395
166MP0005076_abnormal_cell_differentiation0.65740616
167MP0005551_abnormal_eye_electrophysiolog0.65629138
168MP0002876_abnormal_thyroid_physiology0.63836458
169MP0009765_abnormal_xenobiotic_induced0.63665010
170MP0003111_abnormal_nucleus_morphology0.61941413

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)6.57780611
2Short 1st metacarpal (HP:0010034)6.57780611
3Stenosis of the external auditory canal (HP:0000402)6.20226093
4Abnormality of the 1st metacarpal (HP:0010009)5.72992726
5Ectopic kidney (HP:0000086)5.41746594
6Carpal bone hypoplasia (HP:0001498)4.59516308
7Fused cervical vertebrae (HP:0002949)4.42611789
8Short phalanx of the thumb (HP:0009660)4.28525811
9Neurofibrillary tangles (HP:0002185)4.13822861
10Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.10662982
11Degeneration of the lateral corticospinal tracts (HP:0002314)4.10662982
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.89490229
13Absent thumb (HP:0009777)3.86261359
14Peripheral hypomyelination (HP:0007182)3.83926211
15Rectovaginal fistula (HP:0000143)3.70335827
16Rectal fistula (HP:0100590)3.70335827
17Abnormality of the renal collecting system (HP:0004742)3.70233277
18Premature rupture of membranes (HP:0001788)3.55916346
19Duplicated collecting system (HP:0000081)3.54052375
20Synostosis of carpal bones (HP:0005048)3.49654134
21Chromsome breakage (HP:0040012)3.47243807
22Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.45487091
23* Onion bulb formation (HP:0003383)3.37876347
24Absent radius (HP:0003974)3.35601814
25Broad metatarsal (HP:0001783)3.34641051
26Aplasia involving bones of the extremities (HP:0009825)3.23778427
27Aplasia involving bones of the upper limbs (HP:0009823)3.23778427
28Aplasia of the phalanges of the hand (HP:0009802)3.23778427
29Intestinal fistula (HP:0100819)3.23213175
30Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.21093876
31Absent forearm bone (HP:0003953)3.19207575
32Aplasia involving forearm bones (HP:0009822)3.19207575
33Termporal pattern (HP:0011008)3.18421281
34Insidious onset (HP:0003587)3.18421281
35Short humerus (HP:0005792)3.16627670
36Cerebral inclusion bodies (HP:0100314)3.15455459
37Abnormality of the corticospinal tract (HP:0002492)3.15014233
38Abnormality of DNA repair (HP:0003254)3.07651819
39Alacrima (HP:0000522)3.07155380
40Myokymia (HP:0002411)3.06361250
41Muscle fiber splitting (HP:0003555)3.05175409
42Supranuclear gaze palsy (HP:0000605)3.01210219
43Vaginal fistula (HP:0004320)3.00791346
44Action tremor (HP:0002345)2.98394928
45Aplasia/Hypoplasia involving the musculature (HP:0001460)2.97855739
46Hyporeflexia of lower limbs (HP:0002600)2.97149992
47Preaxial foot polydactyly (HP:0001841)2.96764627
48Intention tremor (HP:0002080)2.96079826
49Aplasia/hypoplasia of the humerus (HP:0006507)2.93638088
50Osteomalacia (HP:0002749)2.90925240
51Hypoplasia of the iris (HP:0007676)2.87342509
52Shallow orbits (HP:0000586)2.86941483
53Ankle clonus (HP:0011448)2.86640324
54Abnormality of the parathyroid morphology (HP:0011766)2.85852413
55Horseshoe kidney (HP:0000085)2.85280873
56Sensory axonal neuropathy (HP:0003390)2.85276865
57Abnormality of the middle phalanges of the toes (HP:0010183)2.79513061
58Abnormality of the proximal phalanges of the hand (HP:0009834)2.71912482
59Vitreoretinal degeneration (HP:0000655)2.70848943
60Abnormality of the carotid arteries (HP:0005344)2.69064652
61Spastic gait (HP:0002064)2.68623620
62Oligomenorrhea (HP:0000876)2.67335227
63Segmental peripheral demyelination/remyelination (HP:0003481)2.66452143
64Dysmetria (HP:0001310)2.63965407
65Short thumb (HP:0009778)2.63544660
66Coronal craniosynostosis (HP:0004440)2.59316152
67Pendular nystagmus (HP:0012043)2.59303911
68Abnormal auditory evoked potentials (HP:0006958)2.59201188
69Hammertoe (HP:0001765)2.58889246
70Foot dorsiflexor weakness (HP:0009027)2.58395392
71Morphological abnormality of the middle ear (HP:0008609)2.58073057
72Choanal stenosis (HP:0000452)2.55695672
73Reticulocytopenia (HP:0001896)2.55465562
74Scapular winging (HP:0003691)2.54002417
75Humeroradial synostosis (HP:0003041)2.52277575
76Synostosis involving the elbow (HP:0003938)2.52277575
77Maternal diabetes (HP:0009800)2.47554176
78Neoplasm of the oral cavity (HP:0100649)2.45858625
79Increased variability in muscle fiber diameter (HP:0003557)2.45211967
80Aplasia/Hypoplasia of the uvula (HP:0010293)2.44680861
81Abnormality of the foot musculature (HP:0001436)2.40526089
82Abnormality of the nasal septum (HP:0000419)2.40146410
83Difficulty running (HP:0009046)2.39725664
84Carpal synostosis (HP:0009702)2.37312141
85Duplication of thumb phalanx (HP:0009942)2.34790509
86Decreased subcutaneous fat (HP:0001002)2.34323488
87Cerebral hypomyelination (HP:0006808)2.34268244
88Meckel diverticulum (HP:0002245)2.29055361
89Optic nerve coloboma (HP:0000588)2.28594969
90Triphalangeal thumb (HP:0001199)2.27841751
91Decreased lacrimation (HP:0000633)2.27506174
92Protrusio acetabuli (HP:0003179)2.27139227
93Hypoplasia of the ulna (HP:0003022)2.24078489
94Buphthalmos (HP:0000557)2.22930651
95Hypoalphalipoproteinemia (HP:0003233)2.22603642
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.21260844
97Abnormality of the ileum (HP:0001549)2.20744918
98Megalencephaly (HP:0001355)2.20364297
99Scanning speech (HP:0002168)2.19393545
100Chorioretinal atrophy (HP:0000533)2.18259916
101Stridor (HP:0010307)2.16695656
102Vertebral fusion (HP:0002948)2.16387085
103Increased corneal curvature (HP:0100692)2.16166689
104Keratoconus (HP:0000563)2.16166689
105Infantile muscular hypotonia (HP:0008947)2.15975747
106Lower limb muscle weakness (HP:0007340)2.15919546
107Short hallux (HP:0010109)2.15755920
108Premature skin wrinkling (HP:0100678)2.14277878
109Decreased motor nerve conduction velocity (HP:0003431)2.13651911
110Atrophic scars (HP:0001075)2.12838201
111Bladder diverticulum (HP:0000015)2.12812824
112Overriding aorta (HP:0002623)2.12727096
113Anal stenosis (HP:0002025)2.12470739
114Bronchomalacia (HP:0002780)2.06475518
115Renal agenesis (HP:0000104)2.04768258
116Round ear (HP:0100830)2.03108355
117Abnormality of the phalanges of the 2nd finger (HP:0009541)2.02473815
118Gowers sign (HP:0003391)2.02127517
119Reduced subcutaneous adipose tissue (HP:0003758)2.02043437
120Absent toe (HP:0010760)2.01194057
121Bell-shaped thorax (HP:0001591)2.00152038
122Abnormality of subcutaneous fat tissue (HP:0001001)1.94409812
123Synostosis involving bones of the hand (HP:0004278)1.93082549
124Abnormality of skeletal muscle fiber size (HP:0012084)1.92718717
125Aplasia/Hypoplasia of the hallux (HP:0008362)1.92473729
126Tachypnea (HP:0002789)1.90995719
127Ulnar claw (HP:0001178)1.89379755
128Abnormality of dentin (HP:0010299)1.89376754
129Congenital sensorineural hearing impairment (HP:0008527)1.88549076
130Anteriorly placed anus (HP:0001545)1.86814345
131Steppage gait (HP:0003376)1.85398643
132Distal sensory impairment (HP:0002936)1.84614078
133Aplasia/Hypoplasia of the ulna (HP:0006495)1.84436997
134Lower limb amyotrophy (HP:0007210)1.83639497
135Turricephaly (HP:0000262)1.82175089
136Focal seizures (HP:0007359)1.81810945
137Cutaneous finger syndactyly (HP:0010554)1.81631599
138Torticollis (HP:0000473)1.81176990
139Ankle contracture (HP:0006466)1.80542264
140Upper limb amyotrophy (HP:0009129)1.80401696
141Distal upper limb amyotrophy (HP:0007149)1.80401696
142Urinary urgency (HP:0000012)1.79613911
143Aortic dissection (HP:0002647)1.78519435
144Type 1 muscle fiber predominance (HP:0003803)1.78233518
145Ureteral duplication (HP:0000073)1.78191232
146Hypoplasia of the radius (HP:0002984)1.77073145
147Abnormality of the humerus (HP:0003063)1.76778446
148Abnormality of chromosome stability (HP:0003220)1.75466051
149Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.75053546
150Small intestinal stenosis (HP:0012848)1.74388214
151Duodenal stenosis (HP:0100867)1.74388214
152Abnormality of the upper arm (HP:0001454)1.74291817
153Arnold-Chiari malformation (HP:0002308)1.74279803
154Abnormal number of incisors (HP:0011064)1.74239404
155Renal hypoplasia (HP:0000089)1.71732979
156Fragile skin (HP:0001030)1.71110321
157Slow saccadic eye movements (HP:0000514)1.70479969
158Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.70309832
159Retinal dysplasia (HP:0007973)1.69487945
160Follicular hyperkeratosis (HP:0007502)1.68741313
161Spinal rigidity (HP:0003306)1.68323174
162Abnormality of the preputium (HP:0100587)1.68181132
163Focal motor seizures (HP:0011153)1.67953853
164Slow progression (HP:0003677)1.67627908
165Facial asymmetry (HP:0000324)1.67461604
166Genetic anticipation (HP:0003743)1.66663934
167Centrally nucleated skeletal muscle fibers (HP:0003687)1.66285851
168Insomnia (HP:0100785)1.66092990
169Abolished electroretinogram (ERG) (HP:0000550)1.66024898
170Abnormality of the phalanges of the 5th finger (HP:0004213)1.65840266
171Flat cornea (HP:0007720)1.65681250
172Esotropia (HP:0000565)1.64228420
173Exercise-induced myalgia (HP:0003738)1.63034791
174Cerebral aneurysm (HP:0004944)1.62427272
175Clonus (HP:0002169)1.60294440
176EMG: myopathic abnormalities (HP:0003458)1.59642434
177Axonal loss (HP:0003447)1.58789590
178Severe muscular hypotonia (HP:0006829)1.58591206
179Clumsiness (HP:0002312)1.58218981
180Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.57800058
181Preaxial hand polydactyly (HP:0001177)1.57385995
182Hyperextensible skin (HP:0000974)1.57358173
183Long nose (HP:0003189)1.55743726
184Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.55237661
185Broad hallux (HP:0010055)1.55219417
186Aplasia/Hypoplasia of the sternum (HP:0006714)1.54647781
187Wormian bones (HP:0002645)1.54299256
188Pheochromocytoma (HP:0002666)1.54285341
189Cutaneous syndactyly (HP:0012725)1.53295461
190Abnormality of the duodenum (HP:0002246)1.52403993
191Morphological abnormality of the inner ear (HP:0011390)1.52144821
192Acanthocytosis (HP:0001927)1.52131212
193Abnormality of the calf musculature (HP:0001430)1.51198286
194Symphalangism affecting the phalanges of the hand (HP:0009773)1.50605293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.88321133
2GRK13.93544108
3CDC73.29693093
4FRK3.21621954
5OXSR12.99511544
6EPHB12.94334374
7CDK92.62257915
8WNK32.47699686
9WNK12.37765527
10FGFR22.36019903
11PKN12.26664560
12PRKD32.17191978
13EPHA42.17164999
14MKNK22.12863422
15ZAK2.11590734
16NTRK12.11234001
17BMPR1B2.09595858
18MET2.06982824
19WNK42.06112738
20ICK1.95328621
21PAK61.89795713
22UHMK11.87656599
23PLK21.87483528
24MAPKAPK51.84637849
25ROCK21.80648595
26TYRO31.78759845
27FLT31.78101060
28DDR21.74945788
29DMPK1.74404514
30TAF11.73360949
31ADRBK21.71415984
32BUB11.62995533
33NUAK11.59023305
34MAP2K11.56147141
35BCR1.54975762
36LIMK11.52708754
37MKNK11.50670707
38NEK61.49214910
39PAK31.39591452
40PHKG21.38353735
41PHKG11.38353735
42MARK21.37993726
43TNIK1.35211131
44TLK11.34683805
45CAMK2B1.29907209
46PLK41.29311418
47TGFBR11.29211439
48TTK1.29044201
49CDK191.28114492
50SGK4941.26014780
51SGK2231.26014780
52INSRR1.24710628
53TTN1.23763192
54STK38L1.22255519
55ATR1.22111539
56CAMK2D1.21938217
57LMTK21.21793752
58PINK11.21404939
59PRKD11.20983667
60ACVR1B1.20442426
61PRKCH1.18023956
62PDGFRA1.12783263
63BMX1.12489017
64BRSK21.12283110
65CLK11.08448542
66PLK11.07827987
67CAMK1G1.07416373
68CSNK1A1L1.04955295
69PLK31.04287565
70ROCK11.00289162
71CDK51.00218224
72KSR21.00183487
73NEK20.97894710
74CHEK20.94987620
75WEE10.94649265
76PDGFRB0.90972739
77PTK2B0.90968801
78DYRK20.90066169
79ERBB40.89491887
80RET0.89308035
81AURKA0.88974014
82NTRK30.88538409
83STK30.88077840
84CAMK2G0.87908457
85FGR0.86227263
86PNCK0.86043411
87EPHA30.85056096
88RIPK10.84215189
89CSNK1G30.82104227
90NTRK20.81647948
91LATS10.81147774
92PRPF4B0.79459645
93PTK20.78651155
94VRK20.78404341
95PAK20.78191453
96MYLK0.76417764
97CASK0.76159873
98PDPK10.75925786
99SIK10.75593696
100CSNK1G20.74401418
101CSNK1A10.74343127
102CDK140.73436286
103IRAK20.73390963
104CAMK2A0.73185654
105MAP4K20.70270661
106PRKD20.69027724
107CSNK1D0.68445657
108CSNK1G10.67724570
109MAP3K90.67524226
110ATM0.66659608
111TRIB30.66576518
112NEK90.65742057
113MINK10.64864960
114CDK150.64079811
115STK110.63227021
116PRKDC0.63221169
117NLK0.63093507
118FYN0.63039345
119PRKCE0.62764307
120MARK10.62412171
121ADRBK10.62166787
122CDC42BPA0.61830261
123MUSK0.61516407
124FGFR10.60813712
125CAMKK10.60599670
126PRKCG0.60249257
127PBK0.60090851
128CHEK10.57795471
129MAP3K20.57428531
130MAP3K70.56823663
131DYRK30.56607530
132CDK180.56544750
133MAP3K40.56522207
134FER0.54735595
135CDK11A0.53935755
136TIE10.53871058
137CAMK1D0.53334535
138GSK3A0.52869990
139VRK10.52117021
140DAPK30.51331743
141PRKCQ0.51271777
142TRIM280.50540796
143PIK3CA0.50384922
144PKN20.49720837
145ILK0.49054209
146PDK10.48511127
147EPHB20.47731189
148ALK0.47334479
149TRPM70.46679853
150MAPK100.45841285
151LATS20.45682200
152RPS6KA20.44884275
153ERBB20.44366728
154GSK3B0.43928332
155MAPK130.43085234
156MAPK150.42061125
157GRK50.41170718
158STK160.40897551
159TGFBR20.40707600
160BRSK10.38592181
161MAPK140.37476575

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.94893397
2Selenocompound metabolism_Homo sapiens_hsa004502.57434915
3Fanconi anemia pathway_Homo sapiens_hsa034602.57433687
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.55915903
5Nitrogen metabolism_Homo sapiens_hsa009102.55287480
6Axon guidance_Homo sapiens_hsa043602.24510735
7Renin-angiotensin system_Homo sapiens_hsa046142.04265078
8Homologous recombination_Homo sapiens_hsa034402.03529356
9Fatty acid elongation_Homo sapiens_hsa000621.89974995
10ECM-receptor interaction_Homo sapiens_hsa045121.78250636
11Steroid biosynthesis_Homo sapiens_hsa001001.78010317
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75319704
13Glutamatergic synapse_Homo sapiens_hsa047241.68305726
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.64880638
15GABAergic synapse_Homo sapiens_hsa047271.64052547
16Gastric acid secretion_Homo sapiens_hsa049711.62532802
17RNA degradation_Homo sapiens_hsa030181.60320384
18Phototransduction_Homo sapiens_hsa047441.59765198
19Ether lipid metabolism_Homo sapiens_hsa005651.59065682
20DNA replication_Homo sapiens_hsa030301.54800166
21Circadian entrainment_Homo sapiens_hsa047131.54511972
22TGF-beta signaling pathway_Homo sapiens_hsa043501.54230642
23Dilated cardiomyopathy_Homo sapiens_hsa054141.52423536
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51740868
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.48417603
26Salivary secretion_Homo sapiens_hsa049701.45957843
27RNA polymerase_Homo sapiens_hsa030201.42996930
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42495899
29Morphine addiction_Homo sapiens_hsa050321.40736200
30Dorso-ventral axis formation_Homo sapiens_hsa043201.40600330
31Cocaine addiction_Homo sapiens_hsa050301.38530649
32One carbon pool by folate_Homo sapiens_hsa006701.37047794
33Tight junction_Homo sapiens_hsa045301.36863112
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31541579
35Focal adhesion_Homo sapiens_hsa045101.31088142
36Renal cell carcinoma_Homo sapiens_hsa052111.27446914
37Renin secretion_Homo sapiens_hsa049241.25283754
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25094235
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24765956
40Gap junction_Homo sapiens_hsa045401.23765780
41Fatty acid biosynthesis_Homo sapiens_hsa000611.23548859
42Cholinergic synapse_Homo sapiens_hsa047251.23478897
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.22984984
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22940954
45Basal transcription factors_Homo sapiens_hsa030221.22485174
46Long-term depression_Homo sapiens_hsa047301.21969398
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21375867
48Dopaminergic synapse_Homo sapiens_hsa047281.18960972
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.18742405
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.18459217
51Melanoma_Homo sapiens_hsa052181.15674493
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.14103295
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13644346
54Long-term potentiation_Homo sapiens_hsa047201.12706193
55Non-homologous end-joining_Homo sapiens_hsa034501.12617122
56Amphetamine addiction_Homo sapiens_hsa050311.12348161
57Thyroid cancer_Homo sapiens_hsa052161.10518208
58cAMP signaling pathway_Homo sapiens_hsa040241.10439053
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08358446
60Olfactory transduction_Homo sapiens_hsa047401.07169771
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06957560
62Mismatch repair_Homo sapiens_hsa034301.06636169
63Hedgehog signaling pathway_Homo sapiens_hsa043401.05758616
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05497291
65Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05420125
66p53 signaling pathway_Homo sapiens_hsa041151.04527769
67Lysine degradation_Homo sapiens_hsa003101.04468905
68Endocytosis_Homo sapiens_hsa041441.03986734
69Oxytocin signaling pathway_Homo sapiens_hsa049211.03843068
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03292699
71Serotonergic synapse_Homo sapiens_hsa047261.03131190
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01905032
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99129850
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98854979
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97743362
76Cell cycle_Homo sapiens_hsa041100.97314074
77Melanogenesis_Homo sapiens_hsa049160.96571949
78Ras signaling pathway_Homo sapiens_hsa040140.95909900
79Nucleotide excision repair_Homo sapiens_hsa034200.95865216
80Synaptic vesicle cycle_Homo sapiens_hsa047210.94663004
81Insulin secretion_Homo sapiens_hsa049110.93916427
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.93886969
83ErbB signaling pathway_Homo sapiens_hsa040120.92703244
84Vitamin B6 metabolism_Homo sapiens_hsa007500.92161090
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91086860
86Nicotine addiction_Homo sapiens_hsa050330.90640632
87Glycerolipid metabolism_Homo sapiens_hsa005610.90171470
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89763139
89GnRH signaling pathway_Homo sapiens_hsa049120.89744239
90Ovarian steroidogenesis_Homo sapiens_hsa049130.89633845
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89615015
92Calcium signaling pathway_Homo sapiens_hsa040200.88869998
93Rap1 signaling pathway_Homo sapiens_hsa040150.88033554
94Pancreatic secretion_Homo sapiens_hsa049720.87597031
95Pathways in cancer_Homo sapiens_hsa052000.87529109
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87085352
97Protein digestion and absorption_Homo sapiens_hsa049740.86933643
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.85906219
99Proteoglycans in cancer_Homo sapiens_hsa052050.85739310
100Cardiac muscle contraction_Homo sapiens_hsa042600.85697977
101Estrogen signaling pathway_Homo sapiens_hsa049150.85464301
102RNA transport_Homo sapiens_hsa030130.84353784
103Amoebiasis_Homo sapiens_hsa051460.83315996
104Hippo signaling pathway_Homo sapiens_hsa043900.82432104
105Linoleic acid metabolism_Homo sapiens_hsa005910.79523024
106Choline metabolism in cancer_Homo sapiens_hsa052310.77603426
107Thyroid hormone synthesis_Homo sapiens_hsa049180.77385654
108Base excision repair_Homo sapiens_hsa034100.76938487
109Adherens junction_Homo sapiens_hsa045200.75903590
110Basal cell carcinoma_Homo sapiens_hsa052170.75538473
111Sulfur relay system_Homo sapiens_hsa041220.75399419
112MAPK signaling pathway_Homo sapiens_hsa040100.73189126
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73017632
114Glioma_Homo sapiens_hsa052140.72929417
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70431413
116Wnt signaling pathway_Homo sapiens_hsa043100.69676550
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69475252
118MicroRNAs in cancer_Homo sapiens_hsa052060.69422838
119Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67704783
120Type II diabetes mellitus_Homo sapiens_hsa049300.67136279
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64919834
122mRNA surveillance pathway_Homo sapiens_hsa030150.63273319
123Fatty acid metabolism_Homo sapiens_hsa012120.63188301
124Sulfur metabolism_Homo sapiens_hsa009200.61875612
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60376832
126Sphingolipid metabolism_Homo sapiens_hsa006000.59716999
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58476554
128Platelet activation_Homo sapiens_hsa046110.57847294
129Oocyte meiosis_Homo sapiens_hsa041140.57415065
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57086114
131Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56557193
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.54709809
133Taste transduction_Homo sapiens_hsa047420.54633069
134Propanoate metabolism_Homo sapiens_hsa006400.53872462
135Inositol phosphate metabolism_Homo sapiens_hsa005620.53281523
136Vibrio cholerae infection_Homo sapiens_hsa051100.52725184
137Maturity onset diabetes of the young_Homo sapiens_hsa049500.51896631
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51549968
139N-Glycan biosynthesis_Homo sapiens_hsa005100.51405806
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49648561
141Tryptophan metabolism_Homo sapiens_hsa003800.49611531
142Pyrimidine metabolism_Homo sapiens_hsa002400.49572558
143Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49373678
144VEGF signaling pathway_Homo sapiens_hsa043700.49143453
145Fat digestion and absorption_Homo sapiens_hsa049750.49025979
146Purine metabolism_Homo sapiens_hsa002300.48054977
147Butanoate metabolism_Homo sapiens_hsa006500.46967574
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46253904
149Vitamin digestion and absorption_Homo sapiens_hsa049770.45683309
150Prion diseases_Homo sapiens_hsa050200.45639697
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.45328959
152Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44397863
153Chemical carcinogenesis_Homo sapiens_hsa052040.42995134
154Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42961830
155Histidine metabolism_Homo sapiens_hsa003400.41611988

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