ARHGEF10L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the RhoGEF subfamily of RhoGTPases. Members of this subfamily are activated by specific guanine nucleotide exchange factors (GEFs) and are involved in signal transduction. The encoded protein shows cytosolic distribution. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)4.45249674
2complement activation, alternative pathway (GO:0006957)3.97182961
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.74828184
4lysine catabolic process (GO:0006554)3.60364722
5lysine metabolic process (GO:0006553)3.60364722
6sarcomere organization (GO:0045214)3.58618416
7negative regulation of potassium ion transmembrane transport (GO:1901380)3.55381899
8regulation of fibrinolysis (GO:0051917)3.50862855
9regulation of apoptotic cell clearance (GO:2000425)3.48111482
10protein carboxylation (GO:0018214)3.39727193
11peptidyl-glutamic acid carboxylation (GO:0017187)3.39727193
12cardiac myofibril assembly (GO:0055003)3.39159734
13regulation of cholesterol esterification (GO:0010872)3.35560369
14positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.35242016
15phospholipid efflux (GO:0033700)3.32122433
162-oxoglutarate metabolic process (GO:0006103)3.31002144
17cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.25901040
18carnitine shuttle (GO:0006853)3.24746486
19regulation of protein activation cascade (GO:2000257)3.24042587
20cell communication involved in cardiac conduction (GO:0086065)3.23622084
21regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.22290286
22positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.19752621
23cell communication by electrical coupling (GO:0010644)3.17695992
24positive regulation of triglyceride lipase activity (GO:0061365)3.16992156
25positive regulation of lipoprotein lipase activity (GO:0051006)3.16992156
26regulation of complement activation (GO:0030449)3.15405973
27cardiac muscle contraction (GO:0060048)3.04350850
28aspartate family amino acid catabolic process (GO:0009068)3.03993838
29plasma lipoprotein particle clearance (GO:0034381)3.03847335
30fatty acid transmembrane transport (GO:1902001)3.03630183
31acute-phase response (GO:0006953)3.01527136
32ventricular cardiac muscle cell action potential (GO:0086005)3.00377031
33dicarboxylic acid biosynthetic process (GO:0043650)2.99899281
34alpha-linolenic acid metabolic process (GO:0036109)2.98051234
35cholesterol efflux (GO:0033344)2.97788944
36myofibril assembly (GO:0030239)2.96213902
37glyoxylate metabolic process (GO:0046487)2.94666873
38bundle of His cell to Purkinje myocyte communication (GO:0086069)2.93444295
39regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.92769785
40plasma lipoprotein particle remodeling (GO:0034369)2.92675153
41protein-lipid complex remodeling (GO:0034368)2.92675153
42macromolecular complex remodeling (GO:0034367)2.92675153
43low-density lipoprotein particle remodeling (GO:0034374)2.88649094
44negative regulation of cell size (GO:0045792)2.86192625
45cell-cell junction maintenance (GO:0045217)2.85647344
46fibrinolysis (GO:0042730)2.83601618
47protein-lipid complex assembly (GO:0065005)2.83520389
48epoxygenase P450 pathway (GO:0019373)2.83198868
49actin-myosin filament sliding (GO:0033275)2.79766165
50muscle filament sliding (GO:0030049)2.79766165
51regulation of membrane protein ectodomain proteolysis (GO:0051043)2.77559601
52cellular modified amino acid catabolic process (GO:0042219)2.76306915
53regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.76123969
54acetyl-CoA metabolic process (GO:0006084)2.72437783
55regulation of fatty acid beta-oxidation (GO:0031998)2.71278203
56sodium ion export (GO:0071436)2.70682201
57regulation of cholesterol storage (GO:0010885)2.69511586
58positive regulation of fatty acid beta-oxidation (GO:0032000)2.69477538
59positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.68981028
60positive regulation of fatty acid biosynthetic process (GO:0045723)2.68761536
61plasma lipoprotein particle assembly (GO:0034377)2.66306219
62glycosphingolipid catabolic process (GO:0046479)2.64465219
63cytoskeletal anchoring at plasma membrane (GO:0007016)2.64345188
64regulation of skeletal muscle contraction (GO:0014819)2.63342435
65tricarboxylic acid cycle (GO:0006099)2.62951498
66regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.60734678
67negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.60244767
68regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.59392321
69cardiac muscle cell development (GO:0055013)2.58078666
70cellular ketone body metabolic process (GO:0046950)2.57002753
71actomyosin structure organization (GO:0031032)2.56506531
72regulation of membrane repolarization (GO:0060306)2.56069735
73kynurenine metabolic process (GO:0070189)2.55963960
74protein-lipid complex subunit organization (GO:0071825)2.55963185
75regulation of macrophage chemotaxis (GO:0010758)2.54229808
76regulation of fatty acid oxidation (GO:0046320)2.53901504
77regulation of p38MAPK cascade (GO:1900744)2.53806244
78regulation of cholesterol homeostasis (GO:2000188)2.52862770
79high-density lipoprotein particle remodeling (GO:0034375)2.52595505
80fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.51196724
81regulation of mononuclear cell migration (GO:0071675)2.50428131
82fat-soluble vitamin biosynthetic process (GO:0042362)2.49170088
83glycogen catabolic process (GO:0005980)2.49018645
84erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.48232617
85L-phenylalanine metabolic process (GO:0006558)2.48232617
86adhesion of symbiont to host cell (GO:0044650)2.48206150
87virion attachment to host cell (GO:0019062)2.48206150
88positive regulation of steroid metabolic process (GO:0045940)2.46979109
89reverse cholesterol transport (GO:0043691)2.46948007
90striated muscle contraction (GO:0006941)2.46493341
91protein activation cascade (GO:0072376)2.46291571
92cardiac cell development (GO:0055006)2.45677858
93erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.45549342
94L-phenylalanine catabolic process (GO:0006559)2.45549342
95plasma lipoprotein particle organization (GO:0071827)2.45300568
96cell junction maintenance (GO:0034331)2.44733440
97carnitine transmembrane transport (GO:1902603)2.43621381
98negative regulation of blood coagulation (GO:0030195)2.43574938
99negative regulation of hemostasis (GO:1900047)2.43574938
100carnitine transport (GO:0015879)2.43288745
101amino-acid betaine transport (GO:0015838)2.43288745
102complement activation (GO:0006956)2.42761617
103positive regulation of cholesterol efflux (GO:0010875)2.42375238
104creatine metabolic process (GO:0006600)2.41934156
105glutamate metabolic process (GO:0006536)2.41756400
106negative regulation of lipid transport (GO:0032369)2.41465317
107adhesion of symbiont to host (GO:0044406)2.41194368
108phospholipid homeostasis (GO:0055091)2.40421136
109positive regulation of cellular amide metabolic process (GO:0034250)2.40217547
110triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.40171819
111glycolipid catabolic process (GO:0019377)2.39558939
112locomotory exploration behavior (GO:0035641)2.39315263
113complement activation, classical pathway (GO:0006958)2.39205745
114adult heart development (GO:0007512)2.38703164
115regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.37361396
116regulation of cytokine secretion involved in immune response (GO:0002739)2.35377278
117positive regulation of fatty acid oxidation (GO:0046321)2.35239286
118sulfur amino acid catabolic process (GO:0000098)2.34976215
119glucan catabolic process (GO:0009251)2.33665766
120tricarboxylic acid metabolic process (GO:0072350)2.32824899
121establishment of nucleus localization (GO:0040023)2.32452494
122layer formation in cerebral cortex (GO:0021819)2.32073302
123regulation of plasminogen activation (GO:0010755)2.31404979
124regulation of synapse structural plasticity (GO:0051823)2.31233415
125fatty acid beta-oxidation (GO:0006635)2.30961173
126alanine transport (GO:0032328)2.30329899
127low-density lipoprotein particle clearance (GO:0034383)2.29486800
128omega-hydroxylase P450 pathway (GO:0097267)2.29020171
129cellular response to thyroid hormone stimulus (GO:0097067)2.28773873
130regulation of fatty acid biosynthetic process (GO:0042304)2.28558365
131cardiac muscle hypertrophy (GO:0003300)2.27770574
132positive regulation of lipid catabolic process (GO:0050996)2.27616668
133response to mercury ion (GO:0046689)2.27571954
134positive regulation of extracellular matrix organization (GO:1903055)2.27307857
135sarcoplasmic reticulum calcium ion transport (GO:0070296)2.26803973
136actin-mediated cell contraction (GO:0070252)2.26762805
1374-hydroxyproline metabolic process (GO:0019471)2.26519934
138negative regulation of fibrinolysis (GO:0051918)2.26384774
139ethanol oxidation (GO:0006069)2.26120162
140oligosaccharide catabolic process (GO:0009313)2.25981415
141positive regulation of lipid storage (GO:0010884)2.25829366
142very-low-density lipoprotein particle assembly (GO:0034379)2.25268082
143activation of MAPKKK activity (GO:0000185)2.25021804
144ketone body metabolic process (GO:1902224)2.23619401
145positive regulation of sodium ion transport (GO:0010765)2.23051364
146short-chain fatty acid metabolic process (GO:0046459)2.22945792
147semaphorin-plexin signaling pathway (GO:0071526)2.22932354
148positive regulation of glycogen biosynthetic process (GO:0045725)2.22724054
149nucleobase catabolic process (GO:0046113)2.22410232
150urea metabolic process (GO:0019627)2.22338513
151pyrimidine nucleobase catabolic process (GO:0006208)2.22090474
152negative regulation of coagulation (GO:0050819)2.22057826
153positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.21841520
154cardiac muscle cell action potential involved in contraction (GO:0086002)2.21790252
155barbed-end actin filament capping (GO:0051016)2.21637932
156regulation of heterotypic cell-cell adhesion (GO:0034114)2.21160070
157membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.21037737
158striated muscle hypertrophy (GO:0014897)2.20997664
159negative regulation of cholesterol transport (GO:0032375)2.20963239
160negative regulation of sterol transport (GO:0032372)2.20963239
161diacylglycerol metabolic process (GO:0046339)2.20577645
162cellular polysaccharide catabolic process (GO:0044247)2.18767587
163regulation of cholesterol biosynthetic process (GO:0045540)2.18723652
164macroautophagy (GO:0016236)2.18480726
165cardiac muscle cell action potential (GO:0086001)2.18460966
166regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.18201306
167mannose metabolic process (GO:0006013)2.18102523
168positive regulation of hemostasis (GO:1900048)2.18033919
169positive regulation of blood coagulation (GO:0030194)2.18033919
170lipoprotein metabolic process (GO:0042157)2.17777408
171fructose metabolic process (GO:0006000)2.17393042
172potassium ion import (GO:0010107)2.16681711
173fatty acid homeostasis (GO:0055089)2.16246466
174blood coagulation, intrinsic pathway (GO:0007597)2.16083327
175positive regulation of coagulation (GO:0050820)2.16068328
176regulation of extracellular matrix organization (GO:1903053)2.14718713
177regulation of extracellular matrix disassembly (GO:0010715)2.13440181
178apoptotic cell clearance (GO:0043277)2.13260267
179activation of protein kinase A activity (GO:0034199)2.12559394
180negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.12131721
181positive regulation of glycogen metabolic process (GO:0070875)2.11240181
182negative regulation of wound healing (GO:0061045)2.11080827
183drug catabolic process (GO:0042737)2.10525200
184acute inflammatory response (GO:0002526)2.10045683
185positive regulation of cholesterol transport (GO:0032376)2.08131839

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.74825377
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.71367758
3RXR_22158963_ChIP-Seq_LIVER_Mouse2.56402789
4PPARA_22158963_ChIP-Seq_LIVER_Mouse2.30895955
5* LXR_22158963_ChIP-Seq_LIVER_Mouse2.26395310
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.23820693
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.17155668
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.12126317
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06837373
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.01256016
11EZH2_22144423_ChIP-Seq_EOC_Human2.01246100
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90086743
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87678898
14* DROSHA_22980978_ChIP-Seq_HELA_Human1.85429230
15EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80149006
16RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80149006
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.79400414
18ERG_21242973_ChIP-ChIP_JURKAT_Human1.78407060
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.77143449
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.74365369
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.70475179
22LXR_22292898_ChIP-Seq_THP-1_Human1.68993384
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.68351433
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67914591
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.64107929
26ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.63356718
27* KDM2B_26808549_Chip-Seq_K562_Human1.61194967
28CLOCK_20551151_ChIP-Seq_293T_Human1.61181369
29ZNF263_19887448_ChIP-Seq_K562_Human1.60451093
30* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58464582
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.57469676
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56869221
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56033422
34TBX20_22080862_ChIP-Seq_HEART_Mouse1.53369181
35TBX20_22328084_ChIP-Seq_HEART_Mouse1.53369181
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53177916
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.52447868
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52132730
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51896400
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51293160
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.51132896
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.49300553
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47840642
44* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47352085
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45917668
46* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45518037
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38291990
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36216544
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35461941
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34360342
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32241520
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31770465
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.30358486
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.29798865
55* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28076438
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27804858
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.27582547
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27062424
59* FOXA2_19822575_ChIP-Seq_HepG2_Human1.26934360
60* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25613508
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.25311506
62SMC4_20622854_ChIP-Seq_HELA_Human1.24607963
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22075172
64TCF7_22412390_ChIP-Seq_EML_Mouse1.21722882
65* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21419847
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20980390
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20918699
68PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.19748408
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19586983
70* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17878664
71AHR_22903824_ChIP-Seq_MCF-7_Human1.17464396
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15136516
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14892747
74KDM2B_26808549_Chip-Seq_DND41_Human1.14455585
75CTCF_27219007_Chip-Seq_Bcells_Human1.12752117
76* RACK7_27058665_Chip-Seq_MCF-7_Human1.11791617
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11173614
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10914733
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08449353
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08281501
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.05065052
82* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04633202
83IRF8_27001747_Chip-Seq_BMDM_Mouse1.04278680
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03416458
85* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03275903
86TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03015296
87* GATA1_19941827_ChIP-Seq_MEL_Mouse1.02640808
88CREB1_26743006_Chip-Seq_LNCaP_Human1.02453319
89AR_21572438_ChIP-Seq_LNCaP_Human1.02422388
90FOXO3_23340844_ChIP-Seq_DLD1_Human1.01426318
91SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01226410
92VDR_21846776_ChIP-Seq_THP-1_Human1.00219692
93TP53_20018659_ChIP-ChIP_R1E_Mouse1.00128352
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99193135
95IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99131597
96P68_20966046_ChIP-Seq_HELA_Human0.97492609
97SA1_27219007_Chip-Seq_ERYTHROID_Human0.97126076
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97090296
99* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96619393
100ARNT_22903824_ChIP-Seq_MCF-7_Human0.95078341
101KDM2B_26808549_Chip-Seq_JURKAT_Human0.94943717
102NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94665030
103* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94252353
104* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93701209
105RUNX1_27514584_Chip-Seq_MCF-7_Human0.92698021
106ISL1_27105846_Chip-Seq_CPCs_Mouse0.92484037
107NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91417625
108ELK3_25401928_ChIP-Seq_HUVEC_Human0.90666429
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90096568
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89991428
111IRF8_22096565_ChIP-ChIP_GC-B_Human0.89648946
112* SMAD4_21741376_ChIP-Seq_HESCs_Human0.89546379
113* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88628433
114* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88601020
115CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88399493
116* SA1_27219007_Chip-Seq_Bcells_Human0.88090759
117PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87936758
118* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87421030
119ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87130950
120* REST_18959480_ChIP-ChIP_MESCs_Mouse0.86969162
121* TP63_22573176_ChIP-Seq_HFKS_Human0.86554789
122JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.85983953
123ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85879875
124NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85367436
125KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84565098
126TET1_21490601_ChIP-Seq_MESCs_Mouse0.84078698
127* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83877905
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83668868

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy4.05243661
2MP0002837_dystrophic_cardiac_calcinosis4.02553770
3MP0003705_abnormal_hypodermis_morpholog3.18714409
4MP0003646_muscle_fatigue3.02967223
5MP0003303_peritoneal_inflammation2.96322091
6MP0004084_abnormal_cardiac_muscle2.93285071
7MP0005360_urolithiasis2.66833741
8MP0005451_abnormal_body_composition2.57027201
9MP0002139_abnormal_hepatobiliary_system2.48995398
10MP0000749_muscle_degeneration2.36737140
11MP0004036_abnormal_muscle_relaxation2.34774267
12MP0004130_abnormal_muscle_cell2.26031270
13MP0003879_abnormal_hair_cell2.22168393
14MP0005083_abnormal_biliary_tract2.21583287
15MP0004858_abnormal_nervous_system2.18228304
16MP0004215_abnormal_myocardial_fiber2.14145559
17MP0004087_abnormal_muscle_fiber2.11898177
18MP0005330_cardiomyopathy2.03228163
19MP0005085_abnormal_gallbladder_physiolo2.00462842
20MP0000747_muscle_weakness1.97815618
21MP0004859_abnormal_synaptic_plasticity1.87384229
22MP0004145_abnormal_muscle_electrophysio1.86888388
23MP0002269_muscular_atrophy1.79887151
24MP0003137_abnormal_impulse_conducting1.79876096
25MP0005365_abnormal_bile_salt1.76071180
26MP0000750_abnormal_muscle_regeneration1.75649267
27MP0006082_CNS_inflammation1.70104787
28MP0002972_abnormal_cardiac_muscle1.65489837
29MP0005620_abnormal_muscle_contractility1.63407633
30MP0003453_abnormal_keratinocyte_physiol1.57033934
31MP0003329_amyloid_beta_deposits1.56916525
32MP0008961_abnormal_basal_metabolism1.54263677
33MP0003283_abnormal_digestive_organ1.53726635
34MP0008438_abnormal_cutaneous_collagen1.53094554
35MP0009840_abnormal_foam_cell1.52456026
36MP0002106_abnormal_muscle_physiology1.50607547
37MP0003436_decreased_susceptibility_to1.46540562
38MP0003252_abnormal_bile_duct1.44562667
39MP0000759_abnormal_skeletal_muscle1.44342974
40MP0005275_abnormal_skin_tensile1.42705755
41MP0004233_abnormal_muscle_weight1.41393699
42MP0010630_abnormal_cardiac_muscle1.41025249
43MP0010329_abnormal_lipoprotein_level1.37946526
44MP0008775_abnormal_heart_ventricle1.37646334
45MP0005409_darkened_coat_color1.37060709
46MP0002998_abnormal_bone_remodeling1.36495657
47MP0009780_abnormal_chondrocyte_physiolo1.34235285
48MP0005623_abnormal_meninges_morphology1.33487347
49MP0005369_muscle_phenotype1.31686075
50MP0005385_cardiovascular_system_phenoty1.31214766
51MP0001544_abnormal_cardiovascular_syste1.31214766
52MP0000343_altered_response_to1.30686107
53MP0000920_abnormal_myelination1.29821655
54MP0002138_abnormal_hepatobiliary_system1.29236314
55MP0005166_decreased_susceptibility_to1.28606107
56MP0002909_abnormal_adrenal_gland1.26233950
57MP0006138_congestive_heart_failure1.25615712
58MP0005257_abnormal_intraocular_pressure1.25477027
59MP0004085_abnormal_heartbeat1.25174833
60MP0003690_abnormal_glial_cell1.24739434
61MP0005332_abnormal_amino_acid1.24055303
62MP0000604_amyloidosis1.23064893
63MP0005666_abnormal_adipose_tissue1.19809888
64MP0010234_abnormal_vibrissa_follicle1.18760885
65MP0001533_abnormal_skeleton_physiology1.17947544
66MP0009785_altered_susceptibility_to1.14320973
67MP0009764_decreased_sensitivity_to1.13810403
68MP0002108_abnormal_muscle_morphology1.13327294
69MP0002971_abnormal_brown_adipose1.12167047
70MP0004185_abnormal_adipocyte_glucose1.11314893
71MP0002234_abnormal_pharynx_morphology1.11052818
72MP0003566_abnormal_cell_adhesion1.09443727
73MP0003724_increased_susceptibility_to1.07516692
74MP0002254_reproductive_system_inflammat1.07006290
75MP0000579_abnormal_nail_morphology1.05038821
76MP0008875_abnormal_xenobiotic_pharmacok1.04976561
77MP0004484_altered_response_of1.04461915
78MP0003183_abnormal_peptide_metabolism1.04452064
79MP0001849_ear_inflammation1.01624747
80MP0008004_abnormal_stomach_pH1.00871037
81MP0000566_synostosis1.00746703
82MP0003123_paternal_imprinting0.99910437
83MP0003635_abnormal_synaptic_transmissio0.99513946
84MP0003279_aneurysm0.99083548
85MP0002118_abnormal_lipid_homeostasis0.97754785
86MP0002148_abnormal_hypersensitivity_rea0.97717305
87MP0004270_analgesia0.96987272
88MP0004510_myositis0.94262079
89MP0002419_abnormal_innate_immunity0.93702623
90MP0002332_abnormal_exercise_endurance0.93666984
91MP0004272_abnormal_basement_membrane0.92184252
92MP0003300_gastrointestinal_ulcer0.92031066
93MP0000733_abnormal_muscle_development0.91466594
94MP0003191_abnormal_cellular_cholesterol0.90559235
95MP0009278_abnormal_bone_marrow0.90274846
96MP0001666_abnormal_nutrient_absorption0.89073333
97MP0005076_abnormal_cell_differentiation0.86807228
98MP0005595_abnormal_vascular_smooth0.86087409
99MP0000569_abnormal_digit_pigmentation0.86016078
100MP0008874_decreased_physiological_sensi0.85371768
101MP0003868_abnormal_feces_composition0.85114987
102MP0008469_abnormal_protein_level0.84160153
103MP0008260_abnormal_autophagy0.83599750
104MP0003195_calcinosis0.83278372
105MP0005375_adipose_tissue_phenotype0.83257009
106MP0004947_skin_inflammation0.83045318
107MP0005025_abnormal_response_to0.83007718
108MP0001958_emphysema0.82067898
109MP0005319_abnormal_enzyme/_coenzyme0.81496003
110MP0000609_abnormal_liver_physiology0.80221768
111MP0003633_abnormal_nervous_system0.80060855
112MP0009046_muscle_twitch0.79993859
113MP0003221_abnormal_cardiomyocyte_apopto0.79826466
114MP0005023_abnormal_wound_healing0.79226401
115MP0005058_abnormal_lysosome_morphology0.79128913
116MP0005670_abnormal_white_adipose0.78864427
117MP0005535_abnormal_body_temperature0.78474015
118MP0001299_abnormal_eye_distance/0.77255581
119MP0003045_fibrosis0.74982260
120MP0002064_seizures0.74710407
121MP0002796_impaired_skin_barrier0.73628949
122MP0005167_abnormal_blood-brain_barrier0.73581922
123MP0004019_abnormal_vitamin_homeostasis0.73295964
124MP0001501_abnormal_sleep_pattern0.73168578
125MP0003075_altered_response_to0.73020877
126MP0000778_abnormal_nervous_system0.72734935
127MP0003172_abnormal_lysosome_physiology0.72131527
128MP0003634_abnormal_glial_cell0.70173571
129MP0005448_abnormal_energy_balance0.69614791
130MP0001790_abnormal_immune_system0.68433113
131MP0005387_immune_system_phenotype0.68433113
132MP0009384_cardiac_valve_regurgitation0.68211114
133MP0000534_abnormal_ureter_morphology0.67651087
134MP0001440_abnormal_grooming_behavior0.67175459
135MP0002089_abnormal_postnatal_growth/wei0.66836443
136MP0002063_abnormal_learning/memory/cond0.66310338
137MP0002896_abnormal_bone_mineralization0.64470057
138MP0004043_abnormal_pH_regulation0.63856930
139MP0008569_lethality_at_weaning0.63350775
140MP0000230_abnormal_systemic_arterial0.62926502
141MP0003632_abnormal_nervous_system0.62815132
142MP0005423_abnormal_somatic_nervous0.62389162
143MP0005584_abnormal_enzyme/coenzyme_acti0.62306474
144MP0001756_abnormal_urination0.62066037
145MP0000467_abnormal_esophagus_morphology0.61200980
146MP0003091_abnormal_cell_migration0.61123422
147MP0009643_abnormal_urine_homeostasis0.60351023

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)5.92355810
2Glomerulonephritis (HP:0000099)4.61865984
3Sudden death (HP:0001699)4.44673716
4Neurofibrillary tangles (HP:0002185)3.94478961
5Exercise-induced myalgia (HP:0003738)3.92260913
6Exercise-induced muscle cramps (HP:0003710)3.88798968
7Hyporeflexia of lower limbs (HP:0002600)3.81903647
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.72749050
9Abnormality of glycolipid metabolism (HP:0010969)3.71368451
10Abnormality of liposaccharide metabolism (HP:0010968)3.71368451
11Abnormality of glycosphingolipid metabolism (HP:0004343)3.71368451
12Right ventricular cardiomyopathy (HP:0011663)3.67000671
13Muscle fiber splitting (HP:0003555)3.46058595
14Difficulty running (HP:0009046)3.44851542
15Increased connective tissue (HP:0009025)3.44035374
16Ventricular tachycardia (HP:0004756)3.41054031
17Calf muscle hypertrophy (HP:0008981)3.25442145
18Dysostosis multiplex (HP:0000943)3.18442869
19Joint hemorrhage (HP:0005261)3.15906797
20Deep venous thrombosis (HP:0002625)3.10100665
21Myoglobinuria (HP:0002913)3.09822307
22Abnormality of the calf musculature (HP:0001430)3.09224907
23Asymmetric septal hypertrophy (HP:0001670)3.08102232
24Muscle hypertrophy of the lower extremities (HP:0008968)3.07423039
25Nuclear cataract (HP:0100018)3.01613589
26Abnormality of aromatic amino acid family metabolism (HP:0004338)3.01281286
27Increased cerebral lipofuscin (HP:0011813)3.00354125
28Bundle branch block (HP:0011710)2.99398164
29Cerebral inclusion bodies (HP:0100314)2.93858992
30Urinary glycosaminoglycan excretion (HP:0003541)2.83008021
31Mucopolysacchariduria (HP:0008155)2.83008021
32Hemorrhage of the eye (HP:0011885)2.81355069
33Abnormality of polysaccharide metabolism (HP:0011012)2.81017831
34Abnormality of glycosaminoglycan metabolism (HP:0004371)2.81017831
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.81017831
36EMG: myopathic abnormalities (HP:0003458)2.80432537
37Lymphangioma (HP:0100764)2.79811537
38Recurrent gram-negative bacterial infections (HP:0005420)2.78010122
39Prolonged partial thromboplastin time (HP:0003645)2.76057484
40Ketoacidosis (HP:0001993)2.73198150
41Ventricular fibrillation (HP:0001663)2.73126593
42Type 1 muscle fiber predominance (HP:0003803)2.72402903
43Nephritis (HP:0000123)2.68179507
44Amyloidosis (HP:0011034)2.67806950
45Atrial fibrillation (HP:0005110)2.67592374
46Myotonia (HP:0002486)2.67273554
47Ventricular arrhythmia (HP:0004308)2.64653886
48Ketosis (HP:0001946)2.63992465
49Mutism (HP:0002300)2.62177595
50Difficulty climbing stairs (HP:0003551)2.61566279
51Increased variability in muscle fiber diameter (HP:0003557)2.57705807
52Disinhibition (HP:0000734)2.54495716
53Primary atrial arrhythmia (HP:0001692)2.51723022
54Supranuclear gaze palsy (HP:0000605)2.51487096
55Abnormality of the Achilles tendon (HP:0005109)2.48962672
56Purpura (HP:0000979)2.48563215
57Xanthomatosis (HP:0000991)2.48225586
58Syncope (HP:0001279)2.45354159
59Loss of speech (HP:0002371)2.40546839
60Heart block (HP:0012722)2.37365321
61Abnormality of the left ventricular outflow tract (HP:0011103)2.36659206
62Subaortic stenosis (HP:0001682)2.36659206
63Atrioventricular block (HP:0001678)2.36105522
64Achilles tendon contracture (HP:0001771)2.35578112
65Gout (HP:0001997)2.34538812
66Supraventricular tachycardia (HP:0004755)2.33294713
67Vacuolated lymphocytes (HP:0001922)2.32251453
68Obstructive sleep apnea (HP:0002870)2.32001536
69Myocardial infarction (HP:0001658)2.31693553
70Supraventricular arrhythmia (HP:0005115)2.31541719
71Abnormal atrioventricular conduction (HP:0005150)2.30979723
72Prolonged QT interval (HP:0001657)2.30793074
73Increased neuronal autofluorescent lipopigment (HP:0002074)2.30213247
74Broad metatarsal (HP:0001783)2.27292716
75Cerebral aneurysm (HP:0004944)2.26792698
76Scapular winging (HP:0003691)2.25544704
77Lipoatrophy (HP:0100578)2.21489330
78Abnormality of skeletal muscle fiber size (HP:0012084)2.21452878
79Complement deficiency (HP:0004431)2.19010900
80Hamartoma of the eye (HP:0010568)2.16541680
81Limb-girdle muscle atrophy (HP:0003797)2.16524554
82Malnutrition (HP:0004395)2.16060388
83Nemaline bodies (HP:0003798)2.11769506
84Abnormality of the lower motor neuron (HP:0002366)2.11196869
85Skin nodule (HP:0200036)2.09912603
86Upper limb amyotrophy (HP:0009129)2.09489918
87Distal upper limb amyotrophy (HP:0007149)2.09489918
88Thin bony cortex (HP:0002753)2.07761592
89Neuronal loss in central nervous system (HP:0002529)2.07174751
90Palpitations (HP:0001962)2.06248930
91Frequent falls (HP:0002359)2.05885758
92Retinal atrophy (HP:0001105)2.05882038
93Hypercholesterolemia (HP:0003124)2.05656573
94Mitral stenosis (HP:0001718)2.05532745
95Hypoalphalipoproteinemia (HP:0003233)2.01409549
96Distal lower limb amyotrophy (HP:0008944)2.01066903
97Turricephaly (HP:0000262)1.99862298
98EMG: neuropathic changes (HP:0003445)1.98888498
99Orchitis (HP:0100796)1.98156182
100Hypoplastic ischia (HP:0003175)1.97636012
101Abnormality of macrophages (HP:0004311)1.97329142
102Mildly elevated creatine phosphokinase (HP:0008180)1.96450012
103Eczematoid dermatitis (HP:0000976)1.95962459
104Long toe (HP:0010511)1.94650955
105Cholelithiasis (HP:0001081)1.93871975
106Dilated cardiomyopathy (HP:0001644)1.93754785
107Hyperammonemia (HP:0001987)1.92606861
108Pathologic fracture (HP:0002756)1.91454487
109Myopathic facies (HP:0002058)1.91432781
110Abnormality of the ischium (HP:0003174)1.90405266
111Increased serum ferritin (HP:0003281)1.88749240
112Lower limb amyotrophy (HP:0007210)1.88364584
113Muscle stiffness (HP:0003552)1.88098655
114Dysmetric saccades (HP:0000641)1.87542970
115Rhabdomyolysis (HP:0003201)1.87208348
116Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86917536
117Apathy (HP:0000741)1.86546781
118Hyperglycinuria (HP:0003108)1.86081956
119Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86069471
120Aneurysm (HP:0002617)1.85360919
121Action tremor (HP:0002345)1.84746764
122Intrahepatic cholestasis (HP:0001406)1.84399189
123Muscle fiber inclusion bodies (HP:0100299)1.83815405
124Distal lower limb muscle weakness (HP:0009053)1.82809939
125Centrally nucleated skeletal muscle fibers (HP:0003687)1.82363512
126Hypolipoproteinemia (HP:0010981)1.81916228
127Hypobetalipoproteinemia (HP:0003563)1.81849261
128Rapidly progressive (HP:0003678)1.80336327
129J-shaped sella turcica (HP:0002680)1.80039398
130Optic neuritis (HP:0100653)1.79218374
131Retrobulbar optic neuritis (HP:0100654)1.79218374
132Dementia (HP:0000726)1.79157806
133Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.77710390
134Conjunctival hamartoma (HP:0100780)1.77528853
135Bulbar palsy (HP:0001283)1.77386555
136Abnormality of the common coagulation pathway (HP:0010990)1.76951156
137Abnormality of glycine metabolism (HP:0010895)1.75036844
138Abnormality of serine family amino acid metabolism (HP:0010894)1.75036844
139Abnormality of glutamine family amino acid metabolism (HP:0010902)1.74755706
140Round ear (HP:0100830)1.74054443
141Hypophosphatemia (HP:0002148)1.73200136
142Abnormal gallbladder morphology (HP:0012437)1.70523033
143Diminished motivation (HP:0000745)1.70426861
144Visceral angiomatosis (HP:0100761)1.70399292
145Shallow orbits (HP:0000586)1.70120719
146Neonatal onset (HP:0003623)1.69946470
147Foot dorsiflexor weakness (HP:0009027)1.69278353
148Hyperlipoproteinemia (HP:0010980)1.69252373
149Back pain (HP:0003418)1.68679686
150Hand muscle atrophy (HP:0009130)1.68527650
151Pheochromocytoma (HP:0002666)1.67436249
152Protuberant abdomen (HP:0001538)1.66930133
153Axonal loss (HP:0003447)1.66793659
154Abnormal EKG (HP:0003115)1.66667317
155Abnormality of the foot musculature (HP:0001436)1.65338642
156Abnormality of complement system (HP:0005339)1.65147651
157Conjugated hyperbilirubinemia (HP:0002908)1.63643725
158Stroke (HP:0001297)1.61154540
159Hyperparathyroidism (HP:0000843)1.60650071
160Termporal pattern (HP:0011008)1.59806258
161Insidious onset (HP:0003587)1.59806258
162Abnormality of proline metabolism (HP:0010907)1.58160346
163Hydroxyprolinuria (HP:0003080)1.58160346
164Esophageal varix (HP:0002040)1.57855869
165Hyperacusis (HP:0010780)1.57653295
166Vascular calcification (HP:0004934)1.57627984

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.11331569
2TTN3.84171911
3LMTK23.08040345
4PKN23.06831199
5PHKG22.70830025
6PHKG12.70830025
7IRAK32.52412107
8RIPK12.21288949
9SIK12.05316161
10PDGFRA1.76971535
11MAP3K91.73836175
12ICK1.68589837
13OBSCN1.67530792
14BCKDK1.66837551
15PRPF4B1.60886590
16PTK61.58879022
17ERN11.57895964
18DMPK1.55869094
19NEK11.55238053
20MAP3K111.51167414
21PAK61.50040341
22DAPK21.49092358
23KSR21.48950179
24NTRK11.47513034
25TYRO31.47380572
26EPHB11.35973943
27MARK21.30807303
28EPHB21.26343913
29MAP3K31.25154761
30DDR21.23325320
31TBK11.21956986
32TAOK21.20661096
33LATS21.19347941
34MAP3K71.18955917
35MAP2K41.18137893
36CAMKK11.17291616
37FGR1.15446078
38PAK31.14765346
39RET1.13691020
40MINK11.11864350
41MATK1.11819299
42ROCK11.09571624
43BLK1.09014676
44FGFR31.08153705
45TYK21.07683468
46PDK31.05662132
47PDK41.05662132
48GRK71.04247064
49STK381.03627344
50MYLK1.03479678
51EPHA21.03035141
52FGFR41.02837840
53MAP3K40.99501412
54MAP2K60.99194016
55WNK40.98989600
56PTK20.98277733
57CAMK1G0.98250215
58MAP2K30.97494285
59BMX0.97323588
60PRKD30.97294535
61KSR10.94324253
62SGK4940.92415661
63SGK2230.92415661
64MAP3K60.92235398
65NTRK30.91500100
66MARK10.90620845
67NTRK20.89994323
68PINK10.88635844
69CAMK1D0.87587214
70FER0.87573714
71LATS10.86181262
72ERBB20.82215939
73NME20.81477220
74EEF2K0.81214887
75CSK0.79785805
76ABL20.78714515
77PRKD10.76847066
78CDC42BPA0.76520947
79FGFR20.76516572
80MOS0.72736976
81SGK20.72088486
82EPHA40.71718655
83MAP3K130.71451223
84PRKAA10.70846812
85MAP3K20.70790779
86TESK10.70615626
87TAOK10.70545672
88ROCK20.69237040
89MAP3K140.69040786
90PDGFRB0.67666212
91MAP3K100.67056108
92INSRR0.66748748
93CAMK40.65820889
94PRKD20.65461340
95CAMK2G0.65187380
96MAPKAPK30.63576666
97TNK20.63278185
98MAPK120.63053517
99MAPK40.62972246
100DYRK1B0.61715276
101RPS6KC10.61505940
102RPS6KL10.61505940
103MST1R0.59653215
104WNK10.59076047
105PIK3CA0.58930450
106STK110.58718663
107PDPK10.58650770
108MAP2K10.57809771
109PRKCH0.57735864
110RPS6KA20.57482581
111UHMK10.57299428
112PDK10.56156636
113SGK30.56105484
114MTOR0.55223607
115PKN10.55083705
116PIM20.54947026
117CDK50.54174789
118STK390.53877140
119JAK10.53071453
120PAK40.52630228
121RIPK40.52577338
122PAK20.51043055
123PIK3CG0.50117176
124DAPK30.50058464
125CHUK0.50038185
126CSF1R0.49962709
127CASK0.49758287
128PRKAA20.49744681
129MAPK70.49602849
130LRRK20.49596581
131MAP3K10.48411920
132SIK20.48411470
133PRKG20.48102894
134IRAK20.47421952
135ZAP700.45894392
136TGFBR20.43964161
137ILK0.43385838
138JAK20.41793327
139CAMK2D0.41720455
140PRKCZ0.40336017
141PRKACG0.39842009
142PDK20.39689793
143GSK3A0.39386084
144EPHA30.38752012

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.31201498
2Other glycan degradation_Homo sapiens_hsa005112.79087410
3Nitrogen metabolism_Homo sapiens_hsa009102.76503419
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.69318188
5Arginine biosynthesis_Homo sapiens_hsa002202.29713948
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.18675914
7Fatty acid degradation_Homo sapiens_hsa000712.18507194
8Propanoate metabolism_Homo sapiens_hsa006401.84292941
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83406609
10Fatty acid metabolism_Homo sapiens_hsa012121.80489443
11Primary bile acid biosynthesis_Homo sapiens_hsa001201.80084994
12Butanoate metabolism_Homo sapiens_hsa006501.79881747
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.76326217
14Dilated cardiomyopathy_Homo sapiens_hsa054141.71637542
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.70678199
16Lysosome_Homo sapiens_hsa041421.64498084
17Pertussis_Homo sapiens_hsa051331.55143165
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54957264
19Histidine metabolism_Homo sapiens_hsa003401.53651633
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.52912218
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49270538
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48495910
23Tryptophan metabolism_Homo sapiens_hsa003801.45294038
24Bile secretion_Homo sapiens_hsa049761.43145836
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.41469980
26PPAR signaling pathway_Homo sapiens_hsa033201.40948734
27Carbon metabolism_Homo sapiens_hsa012001.32661174
28Cardiac muscle contraction_Homo sapiens_hsa042601.31929064
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31881754
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25685902
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22371335
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18869595
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18331516
34Osteoclast differentiation_Homo sapiens_hsa043801.17363907
35Complement and coagulation cascades_Homo sapiens_hsa046101.16347532
36Pyruvate metabolism_Homo sapiens_hsa006201.10493970
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08821593
38Biosynthesis of amino acids_Homo sapiens_hsa012301.05443371
39Lysine degradation_Homo sapiens_hsa003101.03784042
40Starch and sucrose metabolism_Homo sapiens_hsa005000.99673161
41Fatty acid biosynthesis_Homo sapiens_hsa000610.97342521
42Insulin resistance_Homo sapiens_hsa049310.93618211
43Notch signaling pathway_Homo sapiens_hsa043300.90260930
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90127578
45beta-Alanine metabolism_Homo sapiens_hsa004100.85798759
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85554276
47Type II diabetes mellitus_Homo sapiens_hsa049300.85510488
48Retinol metabolism_Homo sapiens_hsa008300.85069449
49Insulin signaling pathway_Homo sapiens_hsa049100.84407237
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.84161637
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83700323
52Mineral absorption_Homo sapiens_hsa049780.83533152
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83122571
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82555773
55TNF signaling pathway_Homo sapiens_hsa046680.81242550
56Focal adhesion_Homo sapiens_hsa045100.81216920
57Galactose metabolism_Homo sapiens_hsa000520.80905706
58Peroxisome_Homo sapiens_hsa041460.80838640
59Malaria_Homo sapiens_hsa051440.79860288
60Gastric acid secretion_Homo sapiens_hsa049710.77851398
61Glucagon signaling pathway_Homo sapiens_hsa049220.76729038
62Tuberculosis_Homo sapiens_hsa051520.74553426
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74405751
64Salmonella infection_Homo sapiens_hsa051320.72786353
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.72753769
66Phenylalanine metabolism_Homo sapiens_hsa003600.70789610
67ECM-receptor interaction_Homo sapiens_hsa045120.70067777
68Synaptic vesicle cycle_Homo sapiens_hsa047210.70000337
69Caffeine metabolism_Homo sapiens_hsa002320.69833735
70mTOR signaling pathway_Homo sapiens_hsa041500.68397443
71Arginine and proline metabolism_Homo sapiens_hsa003300.67978628
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67846998
73Chemical carcinogenesis_Homo sapiens_hsa052040.67133856
74Staphylococcus aureus infection_Homo sapiens_hsa051500.66418978
75Oxytocin signaling pathway_Homo sapiens_hsa049210.65674065
76Rheumatoid arthritis_Homo sapiens_hsa053230.65588891
77Glioma_Homo sapiens_hsa052140.65180535
78AMPK signaling pathway_Homo sapiens_hsa041520.64702419
79Leishmaniasis_Homo sapiens_hsa051400.63763192
80Amoebiasis_Homo sapiens_hsa051460.63059525
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62695514
82Axon guidance_Homo sapiens_hsa043600.62651774
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62518361
84Salivary secretion_Homo sapiens_hsa049700.62500149
85Dorso-ventral axis formation_Homo sapiens_hsa043200.62139775
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60835586
87Fat digestion and absorption_Homo sapiens_hsa049750.60806841
88GnRH signaling pathway_Homo sapiens_hsa049120.60307718
89Prion diseases_Homo sapiens_hsa050200.59019688
90African trypanosomiasis_Homo sapiens_hsa051430.58176183
91Bladder cancer_Homo sapiens_hsa052190.57837856
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57349648
93Estrogen signaling pathway_Homo sapiens_hsa049150.56950319
94Gap junction_Homo sapiens_hsa045400.56625783
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55860517
96Cholinergic synapse_Homo sapiens_hsa047250.55602424
97Hepatitis C_Homo sapiens_hsa051600.55277220
98Proteoglycans in cancer_Homo sapiens_hsa052050.55217496
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.54908161
100Circadian entrainment_Homo sapiens_hsa047130.54399094
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52084304
102Insulin secretion_Homo sapiens_hsa049110.52039064
103Phagosome_Homo sapiens_hsa041450.52019548
104Vitamin B6 metabolism_Homo sapiens_hsa007500.51955979
105Sphingolipid metabolism_Homo sapiens_hsa006000.51783172
106GABAergic synapse_Homo sapiens_hsa047270.51257223
107ABC transporters_Homo sapiens_hsa020100.51066243
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50641154
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50620884
110Renin secretion_Homo sapiens_hsa049240.50440324
111Endometrial cancer_Homo sapiens_hsa052130.50095001
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50080370
113Glutamatergic synapse_Homo sapiens_hsa047240.49688319
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49587875
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49474758
116Tight junction_Homo sapiens_hsa045300.49239899
117Protein digestion and absorption_Homo sapiens_hsa049740.48936291
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48334700
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.48129694
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.47967696
121VEGF signaling pathway_Homo sapiens_hsa043700.47832270
122Vibrio cholerae infection_Homo sapiens_hsa051100.47377125
123Prolactin signaling pathway_Homo sapiens_hsa049170.46132090
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46051425
125Calcium signaling pathway_Homo sapiens_hsa040200.45905482
126Viral myocarditis_Homo sapiens_hsa054160.45386720
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.45212264
128Glycerolipid metabolism_Homo sapiens_hsa005610.45201340
129Fatty acid elongation_Homo sapiens_hsa000620.44904185
130Olfactory transduction_Homo sapiens_hsa047400.43340859
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43101735
132Tyrosine metabolism_Homo sapiens_hsa003500.40101605
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.39417108
134Toxoplasmosis_Homo sapiens_hsa051450.38679313
135Chemokine signaling pathway_Homo sapiens_hsa040620.38566381
136Long-term potentiation_Homo sapiens_hsa047200.38322613
137Adherens junction_Homo sapiens_hsa045200.38060080
138Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36642964
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36620107
140Fructose and mannose metabolism_Homo sapiens_hsa000510.36021757
141Cyanoamino acid metabolism_Homo sapiens_hsa004600.35595040
142Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34778720
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33303514

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