ARHGEF12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.21246000
2desmosome organization (GO:0002934)3.20544343
3locomotory exploration behavior (GO:0035641)3.11584398
4layer formation in cerebral cortex (GO:0021819)2.94154909
5cell communication by electrical coupling (GO:0010644)2.93295109
6synaptic vesicle maturation (GO:0016188)2.89395224
7cell communication involved in cardiac conduction (GO:0086065)2.83828968
8negative regulation of fatty acid transport (GO:2000192)2.83636906
9hemidesmosome assembly (GO:0031581)2.80042589
10cytoskeletal anchoring at plasma membrane (GO:0007016)2.77453312
11positive regulation of fatty acid beta-oxidation (GO:0032000)2.75408561
12regulation of short-term neuronal synaptic plasticity (GO:0048172)2.74270254
13interkinetic nuclear migration (GO:0022027)2.73611185
14plasma membrane repair (GO:0001778)2.68488432
15fatty acid transmembrane transport (GO:1902001)2.67200134
16carnitine shuttle (GO:0006853)2.66806550
17sodium ion export (GO:0071436)2.62939141
18activation of protein kinase A activity (GO:0034199)2.60516275
19endocardial cushion development (GO:0003197)2.59910846
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.57368191
21insulin-like growth factor receptor signaling pathway (GO:0048009)2.56128014
22cytoplasmic mRNA processing body assembly (GO:0033962)2.53497222
23embryonic foregut morphogenesis (GO:0048617)2.53208051
24regulation of hippo signaling (GO:0035330)2.52971128
25iron ion import (GO:0097286)2.51445613
26alpha-linolenic acid metabolic process (GO:0036109)2.50681207
27lymphangiogenesis (GO:0001946)2.49566029
28regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.48143198
29establishment of nucleus localization (GO:0040023)2.46917812
30lysine metabolic process (GO:0006553)2.44848744
31lysine catabolic process (GO:0006554)2.44848744
32dicarboxylic acid biosynthetic process (GO:0043650)2.44056440
33regulation of fatty acid beta-oxidation (GO:0031998)2.43853275
34cell-substrate junction assembly (GO:0007044)2.43363609
35positive regulation of fatty acid oxidation (GO:0046321)2.43179138
36synaptic vesicle docking involved in exocytosis (GO:0016081)2.42167985
37cell adhesion mediated by integrin (GO:0033627)2.40585824
38vocalization behavior (GO:0071625)2.40525072
39import into cell (GO:0098657)2.39962342
40nucleus localization (GO:0051647)2.39439970
41glutamate secretion (GO:0014047)2.38256113
42dendrite morphogenesis (GO:0048813)2.35945644
43myelination in peripheral nervous system (GO:0022011)2.32859102
44peripheral nervous system axon ensheathment (GO:0032292)2.32859102
45positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.32820829
46regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.31495363
47positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.30382951
48cerebellar granule cell differentiation (GO:0021707)2.29311218
49gap junction assembly (GO:0016264)2.27669601
50proline transport (GO:0015824)2.27466421
51neuron remodeling (GO:0016322)2.26503745
52negative regulation of protein localization to cell surface (GO:2000009)2.26257445
53cellular potassium ion homeostasis (GO:0030007)2.26061244
54alanine transport (GO:0032328)2.25284726
55regulation of ARF protein signal transduction (GO:0032012)2.24062785
56positive regulation of cardiac muscle hypertrophy (GO:0010613)2.23682001
57positive regulation of muscle hypertrophy (GO:0014742)2.23682001
58positive regulation of glycogen biosynthetic process (GO:0045725)2.23000729
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.21964472
60regulation of synapse structural plasticity (GO:0051823)2.21215540
61phospholipid translocation (GO:0045332)2.20748064
62lipid translocation (GO:0034204)2.20748064
63protein targeting to Golgi (GO:0000042)2.19687603
64negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.19298900
65pericardium development (GO:0060039)2.18792301
66erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.18772805
67L-phenylalanine catabolic process (GO:0006559)2.18772805
68negative regulation of catenin import into nucleus (GO:0035414)2.18767544
69retina vasculature morphogenesis in camera-type eye (GO:0061299)2.18651798
70potassium ion import (GO:0010107)2.16267160
71regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.16243789
72protein localization to endosome (GO:0036010)2.16154613
73regulation of fatty acid oxidation (GO:0046320)2.15488821
74glutamate metabolic process (GO:0006536)2.15325275
75regulation of axon extension involved in axon guidance (GO:0048841)2.14425740
76relaxation of cardiac muscle (GO:0055119)2.13763277
77chemical homeostasis within a tissue (GO:0048875)2.13740751
78dendritic spine morphogenesis (GO:0060997)2.13355288
79myotube differentiation (GO:0014902)2.13334885
80cardiac myofibril assembly (GO:0055003)2.12825608
81macroautophagy (GO:0016236)2.12259508
82negative regulation of potassium ion transmembrane transport (GO:1901380)2.11788483
83positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.11388877
84regulation of cholesterol homeostasis (GO:2000188)2.11357589
85establishment of protein localization to Golgi (GO:0072600)2.09682141
86apical protein localization (GO:0045176)2.08161342
87vesicle transport along microtubule (GO:0047496)2.06704630
88carnitine transmembrane transport (GO:1902603)2.06303536
89regulation of glutamate receptor signaling pathway (GO:1900449)2.05147256
90surfactant homeostasis (GO:0043129)2.05086093
91embryonic retina morphogenesis in camera-type eye (GO:0060059)2.04947356
92gamma-aminobutyric acid transport (GO:0015812)2.04830814
93myoblast fusion (GO:0007520)2.04575122
94positive regulation of glycogen metabolic process (GO:0070875)2.03621064
95ventricular cardiac muscle cell action potential (GO:0086005)2.03403062
96regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.02858870
97regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.02809751
98regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.02574704
99cellular sodium ion homeostasis (GO:0006883)2.02553327
100artery development (GO:0060840)2.02325862
101cell migration involved in sprouting angiogenesis (GO:0002042)2.01895015
102regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.01870727
103regulation of synaptic vesicle exocytosis (GO:2000300)2.01598164
104mesodermal cell differentiation (GO:0048333)2.01166698
105smooth muscle tissue development (GO:0048745)2.00736439
106retrograde transport, vesicle recycling within Golgi (GO:0000301)2.00430469
1072-oxoglutarate metabolic process (GO:0006103)2.00022968
108amino-acid betaine transport (GO:0015838)1.99948443
109carnitine transport (GO:0015879)1.99948443
110hippo signaling (GO:0035329)1.99191517
111regulation of p38MAPK cascade (GO:1900744)1.99004230
112cell-substrate adherens junction assembly (GO:0007045)1.98672111
113focal adhesion assembly (GO:0048041)1.98672111
114neurotransmitter secretion (GO:0007269)1.98581089
115positive regulation of lipid catabolic process (GO:0050996)1.98431435
116camera-type eye morphogenesis (GO:0048593)1.98380601
117erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)1.98321589
118L-phenylalanine metabolic process (GO:0006558)1.98321589
119membrane repolarization during cardiac muscle cell action potential (GO:0086013)1.98218342
120exploration behavior (GO:0035640)1.97561391
121regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)1.97070458
122adherens junction assembly (GO:0034333)1.96984534
123regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.96693260
124regulation of axon guidance (GO:1902667)1.96665591
125regulation of membrane repolarization (GO:0060306)1.95706674
126vascular endothelial growth factor signaling pathway (GO:0038084)1.95641736
127neuromuscular process controlling balance (GO:0050885)1.95526093
128neurotransmitter-gated ion channel clustering (GO:0072578)1.95421294
129negative regulation of hormone biosynthetic process (GO:0032353)1.95018510
130SMAD protein complex assembly (GO:0007183)1.94902207
131complement activation, alternative pathway (GO:0006957)1.93269121
132stress fiber assembly (GO:0043149)1.92810568
133regulation of transforming growth factor beta2 production (GO:0032909)1.92545823
134glomerular visceral epithelial cell development (GO:0072015)1.91876982
135positive regulation of synapse maturation (GO:0090129)1.91844978
136neuromuscular junction development (GO:0007528)1.91614658
137regulation of clathrin-mediated endocytosis (GO:2000369)1.91571733
138negative regulation of keratinocyte proliferation (GO:0010839)1.91549216
139glycine transport (GO:0015816)1.91376438
140skin morphogenesis (GO:0043589)1.90920554
141bundle of His cell to Purkinje myocyte communication (GO:0086069)1.90894440
142phospholipid homeostasis (GO:0055091)1.90616435
143cardiac conduction (GO:0061337)1.90524617
144aspartate family amino acid catabolic process (GO:0009068)1.90515739
145embryonic camera-type eye morphogenesis (GO:0048596)1.89844429
146regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)1.89697447
147cerebellar Purkinje cell differentiation (GO:0021702)1.89042219
148synaptic vesicle exocytosis (GO:0016079)1.89011378
149sodium ion homeostasis (GO:0055078)1.87974458
150positive regulation of glucose import (GO:0046326)1.87662815
151triglyceride-rich lipoprotein particle remodeling (GO:0034370)1.87536142
152regulation of protein activation cascade (GO:2000257)1.86238992
153peptidyl-tyrosine autophosphorylation (GO:0038083)1.85202387
154regulation of protein polyubiquitination (GO:1902914)1.85187670
155morphogenesis of an epithelial sheet (GO:0002011)1.85075958
156cardiac muscle cell action potential (GO:0086001)1.83979991
157myofibril assembly (GO:0030239)1.83795223
158nerve growth factor signaling pathway (GO:0038180)1.83500413
159neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)1.83408087
160protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)1.83249554
161sequestering of extracellular ligand from receptor (GO:0035581)1.83169710
162clathrin coat assembly (GO:0048268)1.82514129
163protein targeting to plasma membrane (GO:0072661)1.82217766
164membrane assembly (GO:0071709)1.82207817
165asymmetric protein localization (GO:0008105)1.81741995
166regulation of muscle adaptation (GO:0043502)1.80724544

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.48157031
2* ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.34497557
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02657479
4NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.00021279
5* RXR_22158963_ChIP-Seq_LIVER_Mouse1.89745599
6LXR_22158963_ChIP-Seq_LIVER_Mouse1.88917394
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87512926
8TRIM28_21343339_ChIP-Seq_HEK293_Human1.85238816
9EZH2_18974828_ChIP-Seq_MESCs_Mouse1.84048612
10RNF2_18974828_ChIP-Seq_MESCs_Mouse1.84048612
11GBX2_23144817_ChIP-Seq_PC3_Human1.82840248
12DROSHA_22980978_ChIP-Seq_HELA_Human1.82319890
13ZNF217_24962896_ChIP-Seq_MCF-7_Human1.79198064
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74736291
15MTF2_20144788_ChIP-Seq_MESCs_Mouse1.74209008
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71866367
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67037591
18EP300_21415370_ChIP-Seq_HL-1_Mouse1.66152266
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.62712473
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61401982
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61309726
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59763358
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.57790574
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57664957
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54739802
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.51462598
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.49739884
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.48112453
29* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46096676
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44211310
31TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.42698239
32AHR_22903824_ChIP-Seq_MCF-7_Human1.40219167
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.39565902
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.38045425
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.37217467
36* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37205237
37BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35733810
38FOXM1_26456572_ChIP-Seq_MCF-7_Human1.34838181
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.34826105
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34207880
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.33058436
42AR_21572438_ChIP-Seq_LNCaP_Human1.33048207
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.31978156
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31948651
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31731836
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30963739
47CLOCK_20551151_ChIP-Seq_293T_Human1.30810924
48FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.30438810
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30102238
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.28177842
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26644367
52KDM2B_26808549_Chip-Seq_K562_Human1.25347036
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24496367
54* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22688143
55SMAD4_21799915_ChIP-Seq_A2780_Human1.21515697
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18808848
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18521238
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.18290372
59* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18069602
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17202080
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16787629
62TP53_16413492_ChIP-PET_HCT116_Human1.16640958
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16139959
64* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15152294
65* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14747231
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.14371323
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13297169
68* SOX2_21211035_ChIP-Seq_LN229_Gbm1.13036076
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12086606
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10925140
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10925140
72TCF4_23295773_ChIP-Seq_U87_Human1.10504879
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10309679
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09639568
75AR_19668381_ChIP-Seq_PC3_Human1.08519779
76SMAD4_21741376_ChIP-Seq_HESCs_Human1.08333510
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08041166
78SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07949693
79PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07576475
80* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07498663
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.07136755
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06711302
83GATA1_22025678_ChIP-Seq_K562_Human1.06107121
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05967200
85RXR_22108803_ChIP-Seq_LS180_Human1.05107519
86BCAT_22108803_ChIP-Seq_LS180_Human1.04649765
87SMAD3_21741376_ChIP-Seq_HESCs_Human1.04448509
88* TBX20_22328084_ChIP-Seq_HEART_Mouse1.03889972
89* TBX20_22080862_ChIP-Seq_HEART_Mouse1.03889972
90* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03553839
91RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02691285
92ISL1_27105846_Chip-Seq_CPCs_Mouse1.02514309
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01968673
94ZNF263_19887448_ChIP-Seq_K562_Human1.01880153
95TCF4_18268006_ChIP-ChIP_LS174T_Human1.01686723
96FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01518535
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01488512
98STAT3_23295773_ChIP-Seq_U87_Human1.01256006
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99838533
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99789211
101TP63_17297297_ChIP-ChIP_HaCaT_Human0.99324739
102SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99030490
103FOXO3_23340844_ChIP-Seq_DLD1_Human0.98885646
104GATA2_21666600_ChIP-Seq_HMVEC_Human0.98643007
105* REST_21632747_ChIP-Seq_MESCs_Mouse0.98600855
106PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97679459
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96735005
108* TP63_23658742_ChIP-Seq_EP156T_Human0.96175785
109TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96127644
110SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95693399
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95348023
112YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95299726
113RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94124190
114RING1B_27294783_Chip-Seq_ESCs_Mouse0.93445648
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92366683
116TP53_18474530_ChIP-ChIP_U2OS_Human0.92133400
117* CJUN_26792858_Chip-Seq_BT549_Human0.90695927
118SMAD3_21741376_ChIP-Seq_EPCs_Human0.89006316
119AR_25329375_ChIP-Seq_VCAP_Human0.87883174
120ZNF274_21170338_ChIP-Seq_K562_Hela0.87176391
121RING1B_27294783_Chip-Seq_NPCs_Mouse0.86687686

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.17292383
2MP0009780_abnormal_chondrocyte_physiolo2.88572570
3MP0002139_abnormal_hepatobiliary_system2.68840065
4MP0002837_dystrophic_cardiac_calcinosis2.56033654
5MP0005409_darkened_coat_color2.48886384
6MP0003705_abnormal_hypodermis_morpholog2.48158874
7MP0005360_urolithiasis2.43644716
8MP0005365_abnormal_bile_salt2.27713306
9MP0005085_abnormal_gallbladder_physiolo2.22159871
10MP0003252_abnormal_bile_duct2.17571065
11MP0004130_abnormal_muscle_cell2.12688952
12MP0000751_myopathy2.12611870
13MP0010368_abnormal_lymphatic_system2.04773655
14MP0010234_abnormal_vibrissa_follicle2.03457375
15MP0004272_abnormal_basement_membrane2.00463565
16MP0004270_analgesia1.95162133
17MP0004084_abnormal_cardiac_muscle1.93816843
18MP0003950_abnormal_plasma_membrane1.85363314
19MP0002909_abnormal_adrenal_gland1.77712442
20MP0005503_abnormal_tendon_morphology1.72198765
21MP0010352_gastrointestinal_tract_polyps1.72171949
22MP0003635_abnormal_synaptic_transmissio1.68146685
23MP0004215_abnormal_myocardial_fiber1.68032024
24MP0005187_abnormal_penis_morphology1.66520387
25MP0010329_abnormal_lipoprotein_level1.60093167
26MP0000013_abnormal_adipose_tissue1.51794230
27MP0008875_abnormal_xenobiotic_pharmacok1.51731617
28MP0003045_fibrosis1.51609072
29MP0005167_abnormal_blood-brain_barrier1.49343083
30MP0000383_abnormal_hair_follicle1.46989477
31MP0003879_abnormal_hair_cell1.45911601
32MP0004036_abnormal_muscle_relaxation1.45053353
33MP0005666_abnormal_adipose_tissue1.44659499
34MP0005623_abnormal_meninges_morphology1.44406857
35MP0004885_abnormal_endolymph1.43777233
36MP0010678_abnormal_skin_adnexa1.42818801
37MP0008961_abnormal_basal_metabolism1.42702236
38MP0004185_abnormal_adipocyte_glucose1.40754133
39MP0003091_abnormal_cell_migration1.39421207
40MP0003283_abnormal_digestive_organ1.36407484
41MP0004858_abnormal_nervous_system1.35052883
42MP0005275_abnormal_skin_tensile1.32661114
43MP0001348_abnormal_lacrimal_gland1.32173094
44MP0006138_congestive_heart_failure1.29282455
45MP0005670_abnormal_white_adipose1.28093958
46MP0003941_abnormal_skin_development1.27693661
47MP0002063_abnormal_learning/memory/cond1.27002885
48MP0004043_abnormal_pH_regulation1.26655613
49MP0004085_abnormal_heartbeat1.24897538
50MP0004087_abnormal_muscle_fiber1.24220995
51MP0005248_abnormal_Harderian_gland1.21336844
52MP0002009_preneoplasia1.20072357
53MP0005330_cardiomyopathy1.20033708
54MP0008775_abnormal_heart_ventricle1.19187395
55MP0005375_adipose_tissue_phenotype1.17441627
56MP0000569_abnormal_digit_pigmentation1.16541922
57MP0002972_abnormal_cardiac_muscle1.14965758
58MP0008438_abnormal_cutaneous_collagen1.13339719
59MP0001879_abnormal_lymphatic_vessel1.11791222
60MP0002118_abnormal_lipid_homeostasis1.11466945
61MP0003195_calcinosis1.10876878
62* MP0005620_abnormal_muscle_contractility1.10779159
63MP0000566_synostosis1.09636859
64MP0005332_abnormal_amino_acid1.09337174
65MP0000003_abnormal_adipose_tissue1.09023860
66MP0001299_abnormal_eye_distance/1.09000289
67MP0003300_gastrointestinal_ulcer1.08507679
68MP0009745_abnormal_behavioral_response1.08167167
69MP0002822_catalepsy1.07854835
70MP0003329_amyloid_beta_deposits1.07443127
71MP0004484_altered_response_of1.07150167
72MP0005257_abnormal_intraocular_pressure1.03841639
73MP0003137_abnormal_impulse_conducting1.02952930
74MP0002896_abnormal_bone_mineralization1.02608897
75MP0004147_increased_porphyrin_level1.02517232
76MP0002234_abnormal_pharynx_morphology1.02061295
77MP0003890_abnormal_embryonic-extraembry1.01713567
78MP0009384_cardiac_valve_regurgitation1.01504869
79MP0001177_atelectasis1.01027656
80MP0003690_abnormal_glial_cell1.00284910
81MP0002877_abnormal_melanocyte_morpholog0.99804049
82MP0009046_muscle_twitch0.99404026
83MP0000733_abnormal_muscle_development0.96484283
84MP0005083_abnormal_biliary_tract0.95584342
85MP0000462_abnormal_digestive_system0.95576677
86MP0010630_abnormal_cardiac_muscle0.94758406
87MP0004145_abnormal_muscle_electrophysio0.94503595
88MP0000534_abnormal_ureter_morphology0.94094343
89MP0002734_abnormal_mechanical_nocicepti0.92760111
90MP0003942_abnormal_urinary_system0.92712427
91MP0005076_abnormal_cell_differentiation0.92237201
92MP0005385_cardiovascular_system_phenoty0.92148001
93MP0001544_abnormal_cardiovascular_syste0.92148001
94MP0002064_seizures0.91944458
95MP0002108_abnormal_muscle_morphology0.91931401
96MP0002168_other_aberrant_phenotype0.90617346
97MP0000767_abnormal_smooth_muscle0.90251119
98MP0005023_abnormal_wound_healing0.90095172
99MP0001486_abnormal_startle_reflex0.89393992
100MP0000579_abnormal_nail_morphology0.89353979
101MP0000747_muscle_weakness0.89113926
102MP0003633_abnormal_nervous_system0.88397477
103MP0002090_abnormal_vision0.87692986
104MP0002269_muscular_atrophy0.87006351
105MP0000427_abnormal_hair_cycle0.86964670
106MP0004233_abnormal_muscle_weight0.86849747
107MP0000428_abnormal_craniofacial_morphol0.84721668
108MP0004134_abnormal_chest_morphology0.83881572
109MP0003632_abnormal_nervous_system0.83504817
110MP0000749_muscle_degeneration0.83261972
111MP0002295_abnormal_pulmonary_circulatio0.83202927
112MP0000762_abnormal_tongue_morphology0.82050291
113MP0001958_emphysema0.81332523
114MP0005535_abnormal_body_temperature0.80571391
115MP0002078_abnormal_glucose_homeostasis0.79991710
116MP0003646_muscle_fatigue0.79935815
117MP0002572_abnormal_emotion/affect_behav0.79136461
118MP0003868_abnormal_feces_composition0.78777364
119MP0001666_abnormal_nutrient_absorption0.78133841
120MP0004782_abnormal_surfactant_physiolog0.77949325
121MP0009053_abnormal_anal_canal0.76965257
122MP0000778_abnormal_nervous_system0.74697304
123MP0002735_abnormal_chemical_nociception0.74563222
124MP0002971_abnormal_brown_adipose0.74204039
125MP0003385_abnormal_body_wall0.73645026
126MP0003935_abnormal_craniofacial_develop0.73148718
127MP0001849_ear_inflammation0.72451785
128MP0002128_abnormal_blood_circulation0.71803192
129MP0003566_abnormal_cell_adhesion0.71688662
130MP0000537_abnormal_urethra_morphology0.71304690
131MP0001756_abnormal_urination0.71159427
132MP0001440_abnormal_grooming_behavior0.70807147
133MP0008569_lethality_at_weaning0.70649125
134MP0003279_aneurysm0.70298940
135MP0002925_abnormal_cardiovascular_devel0.69203065
136MP0010386_abnormal_urinary_bladder0.68830494
137MP0005386_behavior/neurological_phenoty0.68717682
138MP0004924_abnormal_behavior0.68717682
139MP0003937_abnormal_limbs/digits/tail_de0.67951032
140MP0001661_extended_life_span0.67191068
141MP0003631_nervous_system_phenotype0.66879985
142MP0002184_abnormal_innervation0.65796834

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)3.27114353
2Arterial tortuosity (HP:0005116)2.99319211
3Sudden death (HP:0001699)2.93800944
4Protrusio acetabuli (HP:0003179)2.89579110
5Vascular tortuosity (HP:0004948)2.79638187
6Right ventricular cardiomyopathy (HP:0011663)2.77919175
7Hyporeflexia of lower limbs (HP:0002600)2.69447874
8Action tremor (HP:0002345)2.65046053
9Broad metatarsal (HP:0001783)2.62441285
10Ketoacidosis (HP:0001993)2.55120687
11Lymphangioma (HP:0100764)2.53597047
12Bundle branch block (HP:0011710)2.48489831
13Hypoglycemic coma (HP:0001325)2.43114631
14Aortic dissection (HP:0002647)2.38327338
15Papillary thyroid carcinoma (HP:0002895)2.35456902
16Intrahepatic cholestasis (HP:0001406)2.29244224
17Xanthomatosis (HP:0000991)2.26659671
18Difficulty running (HP:0009046)2.26171460
19Ketosis (HP:0001946)2.21790819
20Ventricular fibrillation (HP:0001663)2.20776632
21Shallow orbits (HP:0000586)2.20756228
22Macroorchidism (HP:0000053)2.20234246
23Hypoalphalipoproteinemia (HP:0003233)2.20204919
24Osteolytic defects of the phalanges of the hand (HP:0009771)2.19300504
25Osteolytic defects of the hand bones (HP:0009699)2.19300504
26Cerebral aneurysm (HP:0004944)2.19024218
27Turricephaly (HP:0000262)2.19017788
28Dysmetric saccades (HP:0000641)2.17647911
29Atrioventricular block (HP:0001678)2.17331420
30Premature rupture of membranes (HP:0001788)2.17156276
31Hyperglycemia (HP:0003074)2.17002774
32Myokymia (HP:0002411)2.16849196
33Hyperventilation (HP:0002883)2.13379100
34Syncope (HP:0001279)2.12824212
35Cardiovascular calcification (HP:0011915)2.10901634
36Focal seizures (HP:0007359)2.10512736
37Prolonged QT interval (HP:0001657)2.10296597
38Epidermoid cyst (HP:0200040)2.09269243
39Atrial fibrillation (HP:0005110)2.08244787
40Bronchomalacia (HP:0002780)2.07090444
41Mitral stenosis (HP:0001718)2.06874421
42Focal segmental glomerulosclerosis (HP:0000097)2.06847071
43Exercise-induced myalgia (HP:0003738)2.06460382
44Complement deficiency (HP:0004431)2.06022918
45Hypoglycemic seizures (HP:0002173)2.04677627
46Focal motor seizures (HP:0011153)2.03928160
47Aneurysm (HP:0002617)2.01780872
48Hyperinsulinemic hypoglycemia (HP:0000825)1.99573075
49Primary atrial arrhythmia (HP:0001692)1.97298849
50Overgrowth (HP:0001548)1.95815280
51Heart block (HP:0012722)1.95228855
52Skin nodule (HP:0200036)1.94867935
53Increased connective tissue (HP:0009025)1.94813925
54Enlarged penis (HP:0000040)1.94180752
55Wormian bones (HP:0002645)1.92976856
56Atrophic scars (HP:0001075)1.92036468
57Impaired social interactions (HP:0000735)1.91872564
58Abnormal social behavior (HP:0012433)1.91872564
59Vertebral arch anomaly (HP:0008438)1.91851165
60Subacute progressive viral hepatitis (HP:0006572)1.90708868
61Abnormal atrioventricular conduction (HP:0005150)1.89464292
62Ventricular arrhythmia (HP:0004308)1.86615817
63Bladder diverticulum (HP:0000015)1.86049993
64Hyperlipoproteinemia (HP:0010980)1.84957516
65Muscle fiber splitting (HP:0003555)1.84932978
66Vascular calcification (HP:0004934)1.84159993
67Flat acetabular roof (HP:0003180)1.83938063
68Glomerulosclerosis (HP:0000096)1.83384381
69Heterotopia (HP:0002282)1.82728160
70Ankyloglossia (HP:0010296)1.82483043
71Renovascular hypertension (HP:0100817)1.81689561
72Aplasia involving bones of the upper limbs (HP:0009823)1.80406726
73Aplasia of the phalanges of the hand (HP:0009802)1.80406726
74Aplasia involving bones of the extremities (HP:0009825)1.80406726
75Hepatoblastoma (HP:0002884)1.78867077
76Supraventricular arrhythmia (HP:0005115)1.78302071
77Limited hip movement (HP:0008800)1.78155109
78Insidious onset (HP:0003587)1.77882873
79Termporal pattern (HP:0011008)1.77882873
80Increased circulating renin level (HP:0000848)1.77815546
81Obstructive sleep apnea (HP:0002870)1.77523449
82Polycythemia (HP:0001901)1.76985412
83Hamartoma of the eye (HP:0010568)1.76952681
84Cubitus valgus (HP:0002967)1.76181580
85Gout (HP:0001997)1.73976822
86Intention tremor (HP:0002080)1.73959701
87Fair hair (HP:0002286)1.73869454
88Supraventricular tachycardia (HP:0004755)1.73656786
89Abnormality of the ischium (HP:0003174)1.72862814
90Hypoplasia of the iris (HP:0007676)1.72255915
91Neonatal short-limb short stature (HP:0008921)1.72225920
92Ventricular tachycardia (HP:0004756)1.70798532
93Visceral angiomatosis (HP:0100761)1.70506699
94Increased variability in muscle fiber diameter (HP:0003557)1.69358520
95Esophageal varix (HP:0002040)1.68609964
96Long toe (HP:0010511)1.68374596
97Abnormality of the calf musculature (HP:0001430)1.67902084
98Postural instability (HP:0002172)1.67305332
99Torticollis (HP:0000473)1.67249021
100Abnormality of the lower motor neuron (HP:0002366)1.66219669
101Hyperactive renin-angiotensin system (HP:0000841)1.65078627
102Hemiplegia (HP:0002301)1.64940626
103Dysdiadochokinesis (HP:0002075)1.64899045
104Genetic anticipation (HP:0003743)1.64336978
105Visual hallucinations (HP:0002367)1.64232734
106Poor eye contact (HP:0000817)1.64149355
107Germ cell neoplasia (HP:0100728)1.64003762
108Myoglobinuria (HP:0002913)1.63877283
109Hyperglycinuria (HP:0003108)1.63721986
110Hemangiomatosis (HP:0007461)1.63308755
111Abnormality of the common coagulation pathway (HP:0010990)1.63104960
112Short nail (HP:0001799)1.62491111
113Generalized hypopigmentation of hair (HP:0011358)1.61887199
114Hyperkalemia (HP:0002153)1.61588958
115Hepatocellular carcinoma (HP:0001402)1.61358875
116Hyperacusis (HP:0010780)1.60957738
117Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.60351566
118Abnormality of monocarboxylic acid metabolism (HP:0010996)1.60250414
119Mildly elevated creatine phosphokinase (HP:0008180)1.60210098
120Blue irides (HP:0000635)1.60174545
121Fragile skin (HP:0001030)1.60129894
122Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.59922676
123Mitral valve prolapse (HP:0001634)1.59296657
124Depression (HP:0000716)1.58683744
125Buphthalmos (HP:0000557)1.58193394
126Hyperammonemia (HP:0001987)1.58156450
127Type 1 muscle fiber predominance (HP:0003803)1.58115316
128Advanced eruption of teeth (HP:0006288)1.57798113
129Insulin-resistant diabetes mellitus (HP:0000831)1.57192669
130Broad face (HP:0000283)1.56590698
131Striae distensae (HP:0001065)1.56032855
132Abnormality of glutamine family amino acid metabolism (HP:0010902)1.55863104
133Hematochezia (HP:0002573)1.55549733
134Cerebral inclusion bodies (HP:0100314)1.55217301
135Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.55018369
136Resting tremor (HP:0002322)1.54750737
137Short chin (HP:0000331)1.54445491
138Aortic aneurysm (HP:0004942)1.54303024
139Lower limb amyotrophy (HP:0007210)1.54206235
140Wide anterior fontanel (HP:0000260)1.54112054
141Status epilepticus (HP:0002133)1.53989207
142Abnormality of the distal phalanx of the thumb (HP:0009617)1.53782124
143Pheochromocytoma (HP:0002666)1.53616794
144Exercise-induced muscle cramps (HP:0003710)1.53089994
145Coronal craniosynostosis (HP:0004440)1.52279334
146Asymmetry of the thorax (HP:0001555)1.49880932
147Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.49858284
148Abnormality of potassium homeostasis (HP:0011042)1.49714368
149Abnormality of the nasal septum (HP:0000419)1.49152231
150Spinal cord compression (HP:0002176)1.48982165
151Spinal rigidity (HP:0003306)1.48699547
152Persistence of primary teeth (HP:0006335)1.46818943
153Cutaneous finger syndactyly (HP:0010554)1.46545006
154Hypoplastic labia majora (HP:0000059)1.46035741
155Insomnia (HP:0100785)1.45987105
156Bradycardia (HP:0001662)1.45748081
157Relative macrocephaly (HP:0004482)1.45687091
158Abnormality of chloride homeostasis (HP:0011422)1.45526081
159Tibial bowing (HP:0002982)1.44819471
160Decreased motor nerve conduction velocity (HP:0003431)1.42415558
161Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.41558805
162Hyperaldosteronism (HP:0000859)1.41477510
163Ulnar bowing (HP:0003031)1.41153403
164Protruding tongue (HP:0010808)1.40845375
165Tracheomalacia (HP:0002779)1.40553574
166Open mouth (HP:0000194)1.40534944
167Soft skin (HP:0000977)1.40169477
168Febrile seizures (HP:0002373)1.39844208
169Metabolic alkalosis (HP:0200114)1.38036604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS12.71578876
2CASK2.66982572
3TRIB32.56865145
4RIPK12.37120373
5EEF2K2.23188889
6NTRK32.12355407
7PRKD32.08132354
8INSRR1.96451574
9SIK11.96091314
10MAP3K91.89999900
11EPHA41.84455708
12MARK11.80312894
13PDGFRA1.77396198
14CAMK1G1.77357588
15LMTK21.76338599
16TRPM71.68889137
17DAPK21.61678048
18PHKG11.60834065
19PHKG21.60834065
20MAP3K21.57361104
21FRK1.56753213
22LATS21.55210040
23MAP3K41.53672446
24PAK61.51506259
25CDK121.51343288
26CAMK1D1.51148769
27FER1.50528949
28TIE11.47861014
29FGFR21.47137003
30STK381.45126978
31PKN21.44084220
32EPHA21.43942868
33NTRK11.43225851
34MAP2K41.41988430
35DMPK1.36749513
36MYLK1.35647362
37TTN1.35001359
38CAMKK11.34167643
39PAK31.33469562
40WNK41.32466462
41NEK91.31196496
42KSR21.29118219
43SGK31.27693328
44PRKCH1.26176445
45EPHB21.26112284
46PTK61.24357168
47RET1.24237733
48STK38L1.20894282
49MINK11.10676584
50DDR21.10120709
51SGK21.05623684
52NTRK21.00397511
53CDC42BPA0.98727894
54TYRO30.97800697
55MAP3K70.96716981
56MST1R0.96469063
57WNK10.95862350
58SGK2230.95687225
59SGK4940.95687225
60ACVR1B0.94048382
61TAOK10.92366553
62PTK20.90612812
63PAK20.88549022
64MAP3K60.88482906
65MELK0.86686406
66FGFR40.86423355
67PRKD10.83468008
68FGFR30.81933658
69PIK3CA0.81371630
70PDGFRB0.80996456
71CDK50.80576720
72KSR10.80525998
73PRKAA10.78309004
74MARK20.77440973
75PDPK10.74813322
76ROCK10.73072553
77ERBB20.71746953
78STK110.71399213
79PNCK0.71107313
80PDK30.68762667
81PDK40.68762667
82BMX0.68686494
83SGK10.65812742
84MAP3K10.63615955
85MAPKAPK30.63590784
86ERN10.62742572
87MET0.62678908
88STK30.62602098
89ICK0.62353469
90PRKAA20.61067744
91STK390.60331563
92RPS6KA20.60086794
93SCYL20.58986392
94FGFR10.58804032
95MTOR0.58747841
96JAK10.58498026
97MAP2K10.58408458
98CAMK10.57118509
99CAMK40.57080971
100WNK30.57008896
101OBSCN0.56726429
102PTK2B0.56072498
103PINK10.55714119
104AKT30.55021124
105ERBB40.54229423
106PDK10.54027878
107OXSR10.51742700
108EPHA30.51337953
109PRKCE0.50817631
110PRKCZ0.49984222
111RPS6KA30.49822971
112CAMK2B0.49353625
113CAMK2A0.49241540
114MAP3K120.48945183
115MAPK100.48542087
116TGFBR20.48394228
117EPHB10.48356694
118NEK60.47946125
119CAMKK20.47897483
120GSK3A0.45168743
121PRKD20.37999166

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.54177490
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.95579925
3Arginine biosynthesis_Homo sapiens_hsa002201.80052803
4Fatty acid degradation_Homo sapiens_hsa000711.71384763
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.71227451
6Primary bile acid biosynthesis_Homo sapiens_hsa001201.67717071
7Bile secretion_Homo sapiens_hsa049761.45789476
8Butanoate metabolism_Homo sapiens_hsa006501.44964660
9Fatty acid metabolism_Homo sapiens_hsa012121.41985885
10PPAR signaling pathway_Homo sapiens_hsa033201.37978211
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36263848
12Insulin secretion_Homo sapiens_hsa049111.28232997
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28009798
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27942784
15Dilated cardiomyopathy_Homo sapiens_hsa054141.27542844
16Propanoate metabolism_Homo sapiens_hsa006401.27092981
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23085506
18Type II diabetes mellitus_Homo sapiens_hsa049301.20646458
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19942622
20Circadian entrainment_Homo sapiens_hsa047131.19904189
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19156642
22Tryptophan metabolism_Homo sapiens_hsa003801.18778639
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18129127
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17770599
25Circadian rhythm_Homo sapiens_hsa047101.15877542
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14103271
27GABAergic synapse_Homo sapiens_hsa047271.13885888
28Gastric acid secretion_Homo sapiens_hsa049711.13856630
29Salivary secretion_Homo sapiens_hsa049701.13233396
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11317168
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11052563
32Fatty acid biosynthesis_Homo sapiens_hsa000611.09219029
33Histidine metabolism_Homo sapiens_hsa003401.07362333
34Renin secretion_Homo sapiens_hsa049241.07330806
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07298647
36Long-term potentiation_Homo sapiens_hsa047201.07184495
37Renal cell carcinoma_Homo sapiens_hsa052111.05520773
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02820442
39Dorso-ventral axis formation_Homo sapiens_hsa043201.01050942
40Glutamatergic synapse_Homo sapiens_hsa047240.99578857
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98664361
42Complement and coagulation cascades_Homo sapiens_hsa046100.97810727
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97537932
44Olfactory transduction_Homo sapiens_hsa047400.96938740
45Insulin resistance_Homo sapiens_hsa049310.96683602
46Lysine degradation_Homo sapiens_hsa003100.94651781
47Hippo signaling pathway_Homo sapiens_hsa043900.94506658
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91704314
49Inositol phosphate metabolism_Homo sapiens_hsa005620.90828381
50Synaptic vesicle cycle_Homo sapiens_hsa047210.90822366
51Amphetamine addiction_Homo sapiens_hsa050310.90401973
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89636327
53Glucagon signaling pathway_Homo sapiens_hsa049220.89114301
54Cholinergic synapse_Homo sapiens_hsa047250.88366985
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87767913
56Morphine addiction_Homo sapiens_hsa050320.87711091
57Choline metabolism in cancer_Homo sapiens_hsa052310.87512782
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86447077
59cAMP signaling pathway_Homo sapiens_hsa040240.85302915
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84117822
61Small cell lung cancer_Homo sapiens_hsa052220.84112479
62Focal adhesion_Homo sapiens_hsa045100.82645310
63Oxytocin signaling pathway_Homo sapiens_hsa049210.82613770
64ECM-receptor interaction_Homo sapiens_hsa045120.82521787
65Nicotine addiction_Homo sapiens_hsa050330.82338643
66MicroRNAs in cancer_Homo sapiens_hsa052060.81790396
67Dopaminergic synapse_Homo sapiens_hsa047280.81557000
68VEGF signaling pathway_Homo sapiens_hsa043700.81164706
69Chronic myeloid leukemia_Homo sapiens_hsa052200.79488255
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.79335290
71Estrogen signaling pathway_Homo sapiens_hsa049150.79329637
72Glioma_Homo sapiens_hsa052140.78779255
73TGF-beta signaling pathway_Homo sapiens_hsa043500.77909896
74Melanoma_Homo sapiens_hsa052180.77391607
75GnRH signaling pathway_Homo sapiens_hsa049120.76974533
76Gap junction_Homo sapiens_hsa045400.76682761
77Cocaine addiction_Homo sapiens_hsa050300.76096590
78beta-Alanine metabolism_Homo sapiens_hsa004100.75842303
79Insulin signaling pathway_Homo sapiens_hsa049100.75001791
80Thyroid hormone synthesis_Homo sapiens_hsa049180.74955308
81Thyroid cancer_Homo sapiens_hsa052160.74392752
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.73730806
83Serotonergic synapse_Homo sapiens_hsa047260.73229083
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72106883
85Melanogenesis_Homo sapiens_hsa049160.71844562
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71811088
87Adherens junction_Homo sapiens_hsa045200.71494172
88ABC transporters_Homo sapiens_hsa020100.71297742
89Non-small cell lung cancer_Homo sapiens_hsa052230.70747397
90* Axon guidance_Homo sapiens_hsa043600.70318600
91Prolactin signaling pathway_Homo sapiens_hsa049170.69877858
92Ras signaling pathway_Homo sapiens_hsa040140.69611295
93AMPK signaling pathway_Homo sapiens_hsa041520.69466014
94* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69433187
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68861098
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.68847087
97Prion diseases_Homo sapiens_hsa050200.67852810
98Pancreatic cancer_Homo sapiens_hsa052120.67496453
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67462210
100Calcium signaling pathway_Homo sapiens_hsa040200.66911549
101Starch and sucrose metabolism_Homo sapiens_hsa005000.66796280
102mTOR signaling pathway_Homo sapiens_hsa041500.66654214
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65142852
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63617654
105* Vascular smooth muscle contraction_Homo sapiens_hsa042700.63518796
106Prostate cancer_Homo sapiens_hsa052150.62748676
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62496703
108Pancreatic secretion_Homo sapiens_hsa049720.62415508
109Amoebiasis_Homo sapiens_hsa051460.62328986
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61959271
111Endometrial cancer_Homo sapiens_hsa052130.60823099
112Protein digestion and absorption_Homo sapiens_hsa049740.60602024
113Taste transduction_Homo sapiens_hsa047420.60064759
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.59946822
115Pyruvate metabolism_Homo sapiens_hsa006200.59934774
116Glycerolipid metabolism_Homo sapiens_hsa005610.58625631
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57260457
118Tight junction_Homo sapiens_hsa045300.55974096
119* Proteoglycans in cancer_Homo sapiens_hsa052050.55612021
120Long-term depression_Homo sapiens_hsa047300.54597872
121Ovarian steroidogenesis_Homo sapiens_hsa049130.54021719
122ErbB signaling pathway_Homo sapiens_hsa040120.51903624
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51524433
124Rap1 signaling pathway_Homo sapiens_hsa040150.51487667
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.51133055
126Peroxisome_Homo sapiens_hsa041460.50323203
127Fat digestion and absorption_Homo sapiens_hsa049750.49479287
128Sulfur metabolism_Homo sapiens_hsa009200.48102633
129Phenylalanine metabolism_Homo sapiens_hsa003600.45664254

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