ARHGEF15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1morphogenesis of an endothelium (GO:0003159)5.05488186
2endothelial tube morphogenesis (GO:0061154)5.05488186
3negative regulation of blood vessel endothelial cell migration (GO:0043537)4.91413705
4angiogenesis involved in wound healing (GO:0060055)4.91354520
5lymph vessel development (GO:0001945)4.66381233
6endothelium development (GO:0003158)4.49789714
7renal filtration (GO:0097205)4.47958977
8regulation of sequestering of triglyceride (GO:0010889)4.43960489
9regulation of cell migration involved in sprouting angiogenesis (GO:0090049)4.42504368
10axon ensheathment in central nervous system (GO:0032291)4.28980101
11central nervous system myelination (GO:0022010)4.28980101
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.16170764
13negative regulation of protein localization to cell surface (GO:2000009)4.11497158
14negative regulation of endothelial cell migration (GO:0010596)4.01308149
15lymphangiogenesis (GO:0001946)3.86068458
16ovulation from ovarian follicle (GO:0001542)3.85503170
17positive regulation of vasculogenesis (GO:2001214)3.82472148
18transcytosis (GO:0045056)3.76426360
19positive regulation of glomerulus development (GO:0090193)3.75839701
20vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.75116037
21endothelial cell morphogenesis (GO:0001886)3.73176673
22positive regulation of urine volume (GO:0035810)3.63264118
23negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.54212131
24positive regulation of endothelial cell differentiation (GO:0045603)3.52008671
25neuron remodeling (GO:0016322)3.51059955
26patterning of blood vessels (GO:0001569)3.47723489
27positive regulation of action potential (GO:0045760)3.44617315
28Notch signaling involved in heart development (GO:0061314)3.42428411
29wound healing, spreading of epidermal cells (GO:0035313)3.39685491
30surfactant homeostasis (GO:0043129)3.38878638
31triglyceride catabolic process (GO:0019433)3.38456486
32regulation of actin filament-based movement (GO:1903115)3.37319331
33nephron epithelium development (GO:0072009)3.36138132
34myofibril assembly (GO:0030239)3.33132338
35vascular endothelial growth factor signaling pathway (GO:0038084)3.28534240
36regulation of vasculogenesis (GO:2001212)3.25723988
37respiratory electron transport chain (GO:0022904)3.23135659
38cardiac myofibril assembly (GO:0055003)3.22817949
39low-density lipoprotein particle clearance (GO:0034383)3.19361131
40ATP synthesis coupled proton transport (GO:0015986)3.17741927
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.17741927
42regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.16277353
43cellular response to epinephrine stimulus (GO:0071872)3.15772132
44regulation of relaxation of muscle (GO:1901077)3.15365566
45heart trabecula formation (GO:0060347)3.15100119
46electron transport chain (GO:0022900)3.14878587
47neuron cell-cell adhesion (GO:0007158)3.12799321
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.12177457
49negative regulation of DNA biosynthetic process (GO:2000279)3.09767852
50sarcomere organization (GO:0045214)3.08546554
51negative regulation of epithelial cell migration (GO:0010633)3.06948438
52ventricular trabecula myocardium morphogenesis (GO:0003222)3.04565425
53blood vessel maturation (GO:0001955)3.03998551
54negative regulation of nitric-oxide synthase activity (GO:0051001)3.03637897
55regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.02066147
56acylglycerol catabolic process (GO:0046464)3.01691162
57neutral lipid catabolic process (GO:0046461)3.01691162
58regulation of cell communication by electrical coupling (GO:0010649)3.01620235
59presynaptic membrane organization (GO:0097090)3.01164940
60arginine catabolic process (GO:0006527)2.98907322
61calcium-mediated signaling using intracellular calcium source (GO:0035584)2.98047685
62artery development (GO:0060840)2.97200523
63chemical homeostasis within a tissue (GO:0048875)2.96045802
64regulation of cardiac muscle cell contraction (GO:0086004)2.94712863
65regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.94557242
66regulation of blood vessel endothelial cell migration (GO:0043535)2.93730172
67vasculogenesis (GO:0001570)2.92144768
68negative regulation of protein autophosphorylation (GO:0031953)2.91902110
69detection of calcium ion (GO:0005513)2.91502434
70response to epinephrine (GO:0071871)2.91284382
71presynaptic membrane assembly (GO:0097105)2.90270387
72membrane assembly (GO:0071709)2.88086428
73long-chain fatty acid biosynthetic process (GO:0042759)2.87711456
74heart trabecula morphogenesis (GO:0061384)2.87578614
75regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.85820327
76endothelial cell proliferation (GO:0001935)2.85393268
77ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.85303072
78adult heart development (GO:0007512)2.85105763
79regulation of cardiac muscle contraction (GO:0055117)2.84628720
80glycerophospholipid catabolic process (GO:0046475)2.84491274
81negative regulation of adherens junction organization (GO:1903392)2.83584373
82negative regulation of focal adhesion assembly (GO:0051895)2.83584373
83negative regulation of cell junction assembly (GO:1901889)2.83584373
84negative regulation of angiogenesis (GO:0016525)2.82530474
85embryonic heart tube development (GO:0035050)2.82169815
86establishment of endothelial barrier (GO:0061028)2.81667239
87* retina vasculature morphogenesis in camera-type eye (GO:0061299)2.81308318
88peptidyl-tyrosine autophosphorylation (GO:0038083)2.80222362
89regulation of the force of heart contraction (GO:0002026)2.78053133
90basement membrane organization (GO:0071711)2.77655793
91regulation of striated muscle contraction (GO:0006942)2.77573075
92response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.77381518
93endothelial cell differentiation (GO:0045446)2.77149197
94axon extension involved in axon guidance (GO:0048846)2.75880104
95neuron projection extension involved in neuron projection guidance (GO:1902284)2.75880104
96regulation of sarcomere organization (GO:0060297)2.73608596
97regulation of urine volume (GO:0035809)2.73456205
98negative regulation of blood vessel morphogenesis (GO:2000181)2.72410379
99neuron recognition (GO:0008038)2.72122749
100cell migration involved in heart development (GO:0060973)2.70310819
101cyclic nucleotide catabolic process (GO:0009214)2.68400276
102cardiac muscle tissue morphogenesis (GO:0055008)2.67769536
103positive regulation of vascular permeability (GO:0043117)2.67382984
104regulation of lipoprotein metabolic process (GO:0050746)2.66285392
105fatty acid transmembrane transport (GO:1902001)2.65845183
106myelination (GO:0042552)2.61909499
107angiogenesis (GO:0001525)2.61839217
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.60452406
109axon ensheathment (GO:0008366)2.59333435
110ensheathment of neurons (GO:0007272)2.59333435
111bundle of His cell to Purkinje myocyte communication (GO:0086069)2.59255854
112endocrine hormone secretion (GO:0060986)2.58587257
113regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.57672652
114negative regulation of vasculature development (GO:1901343)2.57556102
115protein heterotrimerization (GO:0070208)2.57355532
116trabecula morphogenesis (GO:0061383)2.57202826
117positive regulation of receptor recycling (GO:0001921)2.56698435
118metanephric nephron epithelium development (GO:0072243)2.56262091
119positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.55327859
120regulation of integrin-mediated signaling pathway (GO:2001044)2.55217285
121venous blood vessel morphogenesis (GO:0048845)2.54993427
122regulation of endothelial cell migration (GO:0010594)2.54121218
123negative regulation of neurotransmitter transport (GO:0051589)2.51522259
124growth hormone receptor signaling pathway (GO:0060396)2.50910911
125actin-mediated cell contraction (GO:0070252)2.50833484
126blood vessel remodeling (GO:0001974)2.50646657
127vocalization behavior (GO:0071625)2.48329282
128regulation of establishment or maintenance of cell polarity (GO:0032878)2.48188899
129sarcoplasmic reticulum calcium ion transport (GO:0070296)2.47769553
130negative regulation of platelet activation (GO:0010544)2.47091781
131regulation of somitogenesis (GO:0014807)2.45958029
132cAMP catabolic process (GO:0006198)2.45135531
133negative regulation of endothelial cell proliferation (GO:0001937)2.45060152
134regulation of endothelial cell differentiation (GO:0045601)2.43961201
135cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.43683685
136negative regulation of myoblast differentiation (GO:0045662)2.43258072
137positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.43208616
138phagocytosis, recognition (GO:0006910)2.42523513
139heart valve formation (GO:0003188)2.42444471
140response to dietary excess (GO:0002021)2.41948141
141cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.41095399
142regulation of glomerulus development (GO:0090192)2.40467658
143muscle tissue morphogenesis (GO:0060415)2.40403032
144glomerular filtration (GO:0003094)2.39271757
145lipid particle organization (GO:0034389)2.38991162
146limb bud formation (GO:0060174)2.38955408
147positive regulation of smooth muscle cell migration (GO:0014911)2.38186124
148negative regulation of Rho protein signal transduction (GO:0035024)2.36619987
149blood vessel endothelial cell migration (GO:0043534)2.36008390
150enteric nervous system development (GO:0048484)2.35864271
151polyol transport (GO:0015791)2.35842735
152sprouting angiogenesis (GO:0002040)2.35661366
153neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.35557648
154regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.34491009
155regulation of action potential (GO:0098900)2.34183182
156dendritic spine morphogenesis (GO:0060997)2.33248708
157cAMP biosynthetic process (GO:0006171)2.33078052
158regulation of cardioblast differentiation (GO:0051890)2.32596270
159cAMP metabolic process (GO:0046058)2.31955462
160regulation of membrane repolarization (GO:0060306)2.31809053
161negative regulation of axon extension involved in axon guidance (GO:0048843)2.31212961
162cardiac muscle contraction (GO:0060048)2.30567568
163positive regulation of protein kinase C signaling (GO:0090037)2.29139701
164neuronal ion channel clustering (GO:0045161)2.28359841
165regulation of vascular permeability (GO:0043114)2.27651854
166fatty acid elongation (GO:0030497)2.27228444
167negative regulation of cytosolic calcium ion concentration (GO:0051481)2.26814641
168muscle filament sliding (GO:0030049)2.26511350
169actin-myosin filament sliding (GO:0033275)2.26511350
170negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.26364854
171creatine metabolic process (GO:0006600)2.25637780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.35655554
2GBX2_23144817_ChIP-Seq_PC3_Human3.49519868
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.24088048
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.72728582
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67218339
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.59258176
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53578335
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.50053680
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.42654861
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42601706
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37462079
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37462079
13TAF15_26573619_Chip-Seq_HEK293_Human2.36299264
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33288115
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.25926493
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15858116
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04313899
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.02894135
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01718653
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97506908
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.94944907
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.94028088
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93596402
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92588670
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89447025
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.89084320
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87091442
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87036973
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.83103711
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.82321733
31* RNF2_27304074_Chip-Seq_ESCs_Mouse1.73388428
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72910072
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.72597085
34VDR_22108803_ChIP-Seq_LS180_Human1.71953251
35TBX20_22328084_ChIP-Seq_HEART_Mouse1.68267646
36TBX20_22080862_ChIP-Seq_HEART_Mouse1.68267646
37DROSHA_22980978_ChIP-Seq_HELA_Human1.66920609
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63133954
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.63051149
40P300_19829295_ChIP-Seq_ESCs_Human1.53911492
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49975591
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.47622301
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46490885
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45346755
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44786155
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43292506
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.42160131
48SMAD4_21799915_ChIP-Seq_A2780_Human1.41704975
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40925565
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.40849293
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.40681340
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.39758489
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36732988
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34860617
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32756951
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30955673
57AR_21572438_ChIP-Seq_LNCaP_Human1.30929397
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29449010
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29138646
60* ELK3_25401928_ChIP-Seq_HUVEC_Human1.28964034
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28184831
62ER_23166858_ChIP-Seq_MCF-7_Human1.28114118
63NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.27929682
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26954329
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25324046
66REST_21632747_ChIP-Seq_MESCs_Mouse1.23630781
67* GATA2_21666600_ChIP-Seq_HMVEC_Human1.21894665
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21836260
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21600315
70RNF2_27304074_Chip-Seq_NSC_Mouse1.20220767
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19979711
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19879783
73SMC3_22415368_ChIP-Seq_MEFs_Mouse1.19203201
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19177388
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17794769
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17585889
77CJUN_26792858_Chip-Seq_BT549_Human1.17452614
78* CTCF_27219007_Chip-Seq_Bcells_Human1.17168509
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16717912
80* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15483809
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15281489
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14917015
83FLI1_27457419_Chip-Seq_LIVER_Mouse1.14863368
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.14479990
85PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13655332
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13369527
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13270981
88E2F1_18555785_Chip-Seq_ESCs_Mouse1.12692746
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12230991
90BCAT_22108803_ChIP-Seq_LS180_Human1.12050543
91CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11427590
92AHR_22903824_ChIP-Seq_MCF-7_Human1.10775942
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09295326
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08813800
95RUNX2_22187159_ChIP-Seq_PCA_Human1.07735493
96* RING1B_27294783_Chip-Seq_ESCs_Mouse1.07120853
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.06787665
98FUS_26573619_Chip-Seq_HEK293_Human1.05386251
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05137009
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04750350
101WT1_19549856_ChIP-ChIP_CCG9911_Human1.04218592
102NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03614705
103TP53_18474530_ChIP-ChIP_U2OS_Human1.03472263
104P53_22387025_ChIP-Seq_ESCs_Mouse1.02518652
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01857512
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01539146
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00592344
108LXR_22158963_ChIP-Seq_LIVER_Mouse1.00509440
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.00344135
110RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99927870
111STAT3_18555785_Chip-Seq_ESCs_Mouse0.99873193
112EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99819407
113MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99769763
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98223299
115SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98099391
116NFE2_27457419_Chip-Seq_LIVER_Mouse0.97743824
117CMYC_18555785_Chip-Seq_ESCs_Mouse0.97664716
118STAT3_23295773_ChIP-Seq_U87_Human0.97321274
119P300_18555785_Chip-Seq_ESCs_Mouse0.97226482
120TCF4_23295773_ChIP-Seq_U87_Human0.96916041
121ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96578383
122GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95313626
123P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94765069
124POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94727268
125CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94712551
126RXR_22108803_ChIP-Seq_LS180_Human0.94688033
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94342155
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94342155
129TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93473959
130RING1B_27294783_Chip-Seq_NPCs_Mouse0.92194790
131SOX2_21211035_ChIP-Seq_LN229_Gbm0.92132780
132ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91851426
133SMAD4_21741376_ChIP-Seq_HESCs_Human0.90911616
134RUNX1_27457419_Chip-Seq_LIVER_Mouse0.89874655
135TAL1_26923725_Chip-Seq_HPCs_Mouse0.89839082
136ESR1_20079471_ChIP-ChIP_T-47D_Human0.89124635
137CLOCK_20551151_ChIP-Seq_293T_Human0.87972444
138LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87925585
139TP53_20018659_ChIP-ChIP_R1E_Mouse0.86952302
140SOX11_22085726_ChIP-Seq_ESNs_Mouse0.86098239
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85828625
142* MYC_27129775_Chip-Seq_CORNEA_Mouse0.84301910
143ISL1_27105846_Chip-Seq_CPCs_Mouse0.83599428
144GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.81942450
145* TP53_23651856_ChIP-Seq_MEFs_Mouse0.81651772
146PPARA_22158963_ChIP-Seq_LIVER_Mouse0.78375903
147SOX9_24532713_ChIP-Seq_HFSC_Mouse0.78326007
148* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.78303879
149TET1_21490601_ChIP-Seq_MESCs_Mouse0.76968652
150TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.76561820
151RXR_22158963_ChIP-Seq_LIVER_Mouse0.76183681
152IKZF1_21737484_ChIP-ChIP_HCT116_Human0.75994141
153ZNF274_21170338_ChIP-Seq_K562_Hela0.75947111
154SA1_22415368_ChIP-Seq_MEFs_Mouse0.74515762
155FOXH1_21741376_ChIP-Seq_ESCs_Human0.73191398
156CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.73053899
157DNAJC2_21179169_ChIP-ChIP_NT2_Human0.69989208

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system4.25776776
2MP0001879_abnormal_lymphatic_vessel3.51157315
3MP0002837_dystrophic_cardiac_calcinosis3.49358489
4MP0004084_abnormal_cardiac_muscle3.14954311
5MP0003880_abnormal_central_pattern3.12573998
6MP0004215_abnormal_myocardial_fiber3.01911574
7MP0005167_abnormal_blood-brain_barrier2.94383092
8MP0000751_myopathy2.88238468
9MP0003950_abnormal_plasma_membrane2.56121115
10MP0005409_darkened_coat_color2.55510345
11MP0004036_abnormal_muscle_relaxation2.50642168
12MP0004272_abnormal_basement_membrane2.37702388
13MP0003279_aneurysm2.36424868
14MP0005171_absent_coat_pigmentation2.33630083
15MP0002138_abnormal_hepatobiliary_system2.33027593
16MP0003828_pulmonary_edema2.30834374
17MP0006138_congestive_heart_failure2.26928309
18MP0000003_abnormal_adipose_tissue2.09759793
19MP0006276_abnormal_autonomic_nervous2.08098117
20MP0004085_abnormal_heartbeat2.05009486
21MP0005375_adipose_tissue_phenotype2.03049270
22MP0005330_cardiomyopathy2.02169885
23MP0002332_abnormal_exercise_endurance1.98989142
24MP0003646_muscle_fatigue1.92948024
25MP0001188_hyperpigmentation1.89021691
26MP0003137_abnormal_impulse_conducting1.84839164
27MP0001905_abnormal_dopamine_level1.79953840
28MP0004484_altered_response_of1.78362764
29MP0003724_increased_susceptibility_to1.78240130
30MP0002972_abnormal_cardiac_muscle1.76017981
31MP0005666_abnormal_adipose_tissue1.75728731
32MP0001486_abnormal_startle_reflex1.72833953
33MP0008775_abnormal_heart_ventricle1.61276685
34MP0000749_muscle_degeneration1.60697023
35MP0001529_abnormal_vocalization1.59770984
36MP0002933_joint_inflammation1.58999175
37MP0004145_abnormal_muscle_electrophysio1.55708475
38MP0005620_abnormal_muscle_contractility1.55277795
39MP0005385_cardiovascular_system_phenoty1.54210169
40MP0001544_abnormal_cardiovascular_syste1.54210169
41MP0003122_maternal_imprinting1.50774013
42MP0002127_abnormal_cardiovascular_syste1.49822706
43MP0000566_synostosis1.49414377
44MP0009745_abnormal_behavioral_response1.41983389
45MP0002272_abnormal_nervous_system1.41201385
46MP0000249_abnormal_blood_vessel1.39786278
47MP0002971_abnormal_brown_adipose1.36629090
48MP0000465_gastrointestinal_hemorrhage1.35717266
49MP0002064_seizures1.34451813
50MP0002108_abnormal_muscle_morphology1.34232319
51MP0000920_abnormal_myelination1.30162817
52MP0005623_abnormal_meninges_morphology1.28876563
53MP0005645_abnormal_hypothalamus_physiol1.28870126
54MP0002128_abnormal_blood_circulation1.26712215
55MP0003635_abnormal_synaptic_transmissio1.25693873
56MP0005165_increased_susceptibility_to1.24818116
57MP0005595_abnormal_vascular_smooth1.22734955
58MP0009115_abnormal_fat_cell1.22358135
59MP0000230_abnormal_systemic_arterial1.21823324
60MP0001440_abnormal_grooming_behavior1.20271148
61MP0001614_abnormal_blood_vessel1.18515862
62MP0009379_abnormal_foot_pigmentation1.17836373
63MP0002572_abnormal_emotion/affect_behav1.16254710
64MP0002822_catalepsy1.15250753
65MP0004742_abnormal_vestibular_system1.14241196
66MP0003136_yellow_coat_color1.14061765
67MP0002106_abnormal_muscle_physiology1.12373466
68MP0000343_altered_response_to1.12313770
69MP0002876_abnormal_thyroid_physiology1.12166385
70MP0004142_abnormal_muscle_tone1.12073699
71MP0000778_abnormal_nervous_system1.11462128
72MP0001968_abnormal_touch/_nociception1.09107278
73MP0005423_abnormal_somatic_nervous1.08106916
74MP0005275_abnormal_skin_tensile1.07679189
75MP0008995_early_reproductive_senescence1.06586134
76MP0004270_analgesia1.06193766
77MP0004147_increased_porphyrin_level1.06081930
78MP0002067_abnormal_sensory_capabilities1.05783146
79MP0004087_abnormal_muscle_fiber1.05778929
80MP0009697_abnormal_copulation1.05540508
81MP0005386_behavior/neurological_phenoty1.04309964
82MP0004924_abnormal_behavior1.04309964
83MP0001958_emphysema1.03706735
84MP0001502_abnormal_circadian_rhythm1.01766898
85MP0009046_muscle_twitch1.01556095
86MP0005369_muscle_phenotype1.00968803
87MP0004859_abnormal_synaptic_plasticity1.00943412
88MP0005646_abnormal_pituitary_gland1.00042046
89MP0002734_abnormal_mechanical_nocicepti0.99970501
90MP0001501_abnormal_sleep_pattern0.99689346
91MP0010630_abnormal_cardiac_muscle0.99100081
92MP0005670_abnormal_white_adipose0.98758102
93MP0002925_abnormal_cardiovascular_devel0.97059328
94MP0010030_abnormal_orbit_morphology0.96846264
95MP0002063_abnormal_learning/memory/cond0.93946762
96MP0004782_abnormal_surfactant_physiolog0.92464706
97MP0003011_delayed_dark_adaptation0.91913571
98MP0003690_abnormal_glial_cell0.91807598
99MP0005503_abnormal_tendon_morphology0.91804529
100MP0002735_abnormal_chemical_nociception0.91651172
101MP0003303_peritoneal_inflammation0.90790468
102MP0000750_abnormal_muscle_regeneration0.88060575
103MP0000266_abnormal_heart_morphology0.88041988
104MP0002736_abnormal_nociception_after0.87648578
105MP0003959_abnormal_lean_body0.86172380
106MP0004130_abnormal_muscle_cell0.84625092
107MP0006054_spinal_hemorrhage0.84517785
108MP0010329_abnormal_lipoprotein_level0.84274652
109MP0005334_abnormal_fat_pad0.83470649
110MP0000013_abnormal_adipose_tissue0.83170005
111MP0009780_abnormal_chondrocyte_physiolo0.82988332
112MP0002557_abnormal_social/conspecific_i0.82622325
113MP0000767_abnormal_smooth_muscle0.82501172
114MP0001970_abnormal_pain_threshold0.81119163
115MP0002295_abnormal_pulmonary_circulatio0.80323221
116MP0002638_abnormal_pupillary_reflex0.79189113
117MP0002970_abnormal_white_adipose0.78549615
118MP0004883_abnormal_blood_vessel0.78271398
119MP0005551_abnormal_eye_electrophysiolog0.77702480
120MP0000759_abnormal_skeletal_muscle0.76881162
121MP0003948_abnormal_gas_homeostasis0.76735030
122MP0002184_abnormal_innervation0.73996742
123MP0000747_muscle_weakness0.73469971
124MP0003566_abnormal_cell_adhesion0.72075501
125MP0005084_abnormal_gallbladder_morpholo0.72002792
126MP0005535_abnormal_body_temperature0.71792627
127MP0001727_abnormal_embryo_implantation0.71253567
128MP0008438_abnormal_cutaneous_collagen0.69077524
129MP0003633_abnormal_nervous_system0.68466542
130MP0005388_respiratory_system_phenotype0.67733224
131MP0002133_abnormal_respiratory_system0.67733224
132MP0005451_abnormal_body_composition0.67635139
133MP0002102_abnormal_ear_morphology0.67240365
134MP0003705_abnormal_hypodermis_morpholog0.67127920
135MP0001784_abnormal_fluid_regulation0.67103840
136MP0005448_abnormal_energy_balance0.64334267
137MP0002269_muscular_atrophy0.63251647
138MP0003091_abnormal_cell_migration0.58802652
139MP0001661_extended_life_span0.56698529
140MP0003186_abnormal_redox_activity0.55436779
141MP0002118_abnormal_lipid_homeostasis0.53925262
142MP0009384_cardiac_valve_regurgitation0.50933430
143MP0003868_abnormal_feces_composition0.49443305
144MP0005266_abnormal_metabolism0.49100460
145MP0003045_fibrosis0.48921125
146MP0004510_myositis0.45654447
147MP0002932_abnormal_joint_morphology0.42924605
148MP0000733_abnormal_muscle_development0.42798160

Predicted human phenotypes

RankGene SetZ-score
1Hematochezia (HP:0002573)5.43801887
2Lymphangioma (HP:0100764)5.21427421
3Sudden death (HP:0001699)4.81414044
4Esophageal varix (HP:0002040)4.68649166
5Adactyly (HP:0009776)4.50293153
6Atrial fibrillation (HP:0005110)4.45197420
7Nonimmune hydrops fetalis (HP:0001790)4.36915205
8Muscle hypertrophy of the lower extremities (HP:0008968)4.23938128
9Muscle fiber splitting (HP:0003555)4.22278574
10Primary atrial arrhythmia (HP:0001692)4.12154567
11Ventricular tachycardia (HP:0004756)4.10532850
12Calf muscle hypertrophy (HP:0008981)4.09353418
13Increased connective tissue (HP:0009025)4.04274943
14Skull defect (HP:0001362)3.98599123
15Supraventricular arrhythmia (HP:0005115)3.93843755
16Supraventricular tachycardia (HP:0004755)3.91174763
17Wrist flexion contracture (HP:0001239)3.90222655
18Acute necrotizing encephalopathy (HP:0006965)3.78990601
19Portal hypertension (HP:0001409)3.75602271
20Abnormality of skeletal muscle fiber size (HP:0012084)3.66643319
21Prolonged QT interval (HP:0001657)3.62559622
22Difficulty climbing stairs (HP:0003551)3.60657593
23Oligomenorrhea (HP:0000876)3.60152708
24Spinal rigidity (HP:0003306)3.47323966
25Type 1 muscle fiber predominance (HP:0003803)3.36715396
26Cerebral hemorrhage (HP:0001342)3.35942385
27Abnormality of the hepatic vasculature (HP:0006707)3.35714569
28Muscle fiber inclusion bodies (HP:0100299)3.35572459
29Syncope (HP:0001279)3.31775371
30Parakeratosis (HP:0001036)3.30660781
31Cerebral aneurysm (HP:0004944)3.26184601
32Abnormal mitochondria in muscle tissue (HP:0008316)3.23838361
33Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.23474509
34Nemaline bodies (HP:0003798)3.17434468
35Abnormality of the calf musculature (HP:0001430)3.14526457
36Acute encephalopathy (HP:0006846)3.08363336
37Protrusio acetabuli (HP:0003179)3.07340035
38Progressive macrocephaly (HP:0004481)3.07310621
39Asymmetric septal hypertrophy (HP:0001670)3.06859320
40Mitochondrial inheritance (HP:0001427)3.04060345
41Visceral angiomatosis (HP:0100761)2.97963165
42Lipoatrophy (HP:0100578)2.91918719
43Exercise-induced myalgia (HP:0003738)2.90016552
44Hyporeflexia of lower limbs (HP:0002600)2.89436950
45Porencephaly (HP:0002132)2.78643940
46Myotonia (HP:0002486)2.74780856
47Sensory axonal neuropathy (HP:0003390)2.74061925
48Limb dystonia (HP:0002451)2.72986561
49Hemorrhage of the eye (HP:0011885)2.68260836
50Dilated cardiomyopathy (HP:0001644)2.66605463
51Hemangiomatosis (HP:0007461)2.66406712
52Pulmonary artery stenosis (HP:0004415)2.63348483
53Abnormal EKG (HP:0003115)2.62703386
54Pigmentary retinal degeneration (HP:0001146)2.62610964
55Hip contracture (HP:0003273)2.61214310
56Hypoplasia of the iris (HP:0007676)2.60184641
57EMG: myopathic abnormalities (HP:0003458)2.59782705
58Absent hand (HP:0004050)2.55416965
59Optic disc pallor (HP:0000543)2.54005550
60Focal motor seizures (HP:0011153)2.50096295
61Dynein arm defect of respiratory motile cilia (HP:0012255)2.45562239
62Absent/shortened dynein arms (HP:0200106)2.45562239
63Conjunctival telangiectasia (HP:0000524)2.41202117
64Increased CSF lactate (HP:0002490)2.41151320
65Acanthosis nigricans (HP:0000956)2.40398803
66Hepatocellular necrosis (HP:0001404)2.40146175
67Heart block (HP:0012722)2.39431106
68Delayed CNS myelination (HP:0002188)2.38997805
69Renal Fanconi syndrome (HP:0001994)2.37889643
70Palpitations (HP:0001962)2.36803741
71Aortic aneurysm (HP:0004942)2.35133756
72Aplasia cutis congenita (HP:0001057)2.34897167
73Duplicated collecting system (HP:0000081)2.34439714
74Spontaneous hematomas (HP:0007420)2.33871667
75Atonic seizures (HP:0010819)2.33228193
76Abnormality of the nasal mucosa (HP:0000433)2.31113236
77Round ear (HP:0100830)2.29577368
78Neck muscle weakness (HP:0000467)2.26707410
79Pulmonary hypertension (HP:0002092)2.26537988
80Hypoplastic left heart (HP:0004383)2.25543953
81Type II lissencephaly (HP:0007260)2.24136784
82Venous insufficiency (HP:0005293)2.23930401
83Generalized muscle weakness (HP:0003324)2.22847987
84Atrioventricular block (HP:0001678)2.21433851
85Muscular dystrophy (HP:0003560)2.20567422
86Febrile seizures (HP:0002373)2.20491430
87Abnormality of the left ventricular outflow tract (HP:0011103)2.19852027
88Subaortic stenosis (HP:0001682)2.19852027
89Areflexia of lower limbs (HP:0002522)2.19501235
90Mesangial abnormality (HP:0001966)2.18207220
91Abnormal ciliary motility (HP:0012262)2.16069731
92Hepatic necrosis (HP:0002605)2.15570599
93Increased hepatocellular lipid droplets (HP:0006565)2.14866671
94Retinal atrophy (HP:0001105)2.14452225
95Bulbous nose (HP:0000414)2.13969943
96Bundle branch block (HP:0011710)2.12678743
97Abnormal atrioventricular conduction (HP:0005150)2.12126346
98Distal arthrogryposis (HP:0005684)2.11932382
99Congenital malformation of the right heart (HP:0011723)2.11774222
100Double outlet right ventricle (HP:0001719)2.11774222
101Stroke (HP:0001297)2.11071582
102Congenital sensorineural hearing impairment (HP:0008527)2.09301940
103Cerebral edema (HP:0002181)2.08580475
104Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08561243
105Decreased circulating renin level (HP:0003351)2.08427020
106Lipid accumulation in hepatocytes (HP:0006561)2.05804385
107Leukodystrophy (HP:0002415)2.04939901
108High pitched voice (HP:0001620)2.04648133
1093-Methylglutaconic aciduria (HP:0003535)2.04629532
110Joint hemorrhage (HP:0005261)2.03576166
111Left ventricular hypertrophy (HP:0001712)2.03401879
112Exercise intolerance (HP:0003546)2.03145504
113Cavernous hemangioma (HP:0001048)2.02950708
114Hypertriglyceridemia (HP:0002155)2.01975872
115Difficulty running (HP:0009046)2.01145645
116Hyperventilation (HP:0002883)2.00983618
117Centrally nucleated skeletal muscle fibers (HP:0003687)2.00317269
118Limited hip movement (HP:0008800)1.99986078
119Frequent falls (HP:0002359)1.98865641
120Pheochromocytoma (HP:0002666)1.96614606
121Abnormality of the pulmonary veins (HP:0011718)1.96479998
122Polycythemia (HP:0001901)1.96405063
123Aortic valve stenosis (HP:0001650)1.96032155
124Malignant hyperthermia (HP:0002047)1.95293413
125Abnormality of the renal collecting system (HP:0004742)1.94750111
126Bulbar palsy (HP:0001283)1.93461457
127Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.91391203
128Bradycardia (HP:0001662)1.91212409
129Broad metatarsal (HP:0001783)1.89161827
130Hemiplegia (HP:0002301)1.88962800
131Hypothermia (HP:0002045)1.88424228
132Respiratory failure (HP:0002878)1.87459075
133Venous abnormality (HP:0002624)1.86955217
134EMG: neuropathic changes (HP:0003445)1.86381774
135Hypoplastic heart (HP:0001961)1.85987395
136Ectopia lentis (HP:0001083)1.85731701
137Vascular tortuosity (HP:0004948)1.85351316
138Degeneration of the lateral corticospinal tracts (HP:0002314)1.84869863
139Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.84869863
140Congenital hepatic fibrosis (HP:0002612)1.84749323
141Mildly elevated creatine phosphokinase (HP:0008180)1.84485721
142Striae distensae (HP:0001065)1.84251338
143Increased circulating renin level (HP:0000848)1.83615697
144Ventricular fibrillation (HP:0001663)1.82701897
145Abnormality of the vitreous humor (HP:0004327)1.82543765
146Abnormality of secondary sexual hair (HP:0009888)1.81555214
147Abnormality of the axillary hair (HP:0100134)1.81555214
148Cerebellar dysplasia (HP:0007033)1.81251209
149Broad-based gait (HP:0002136)1.80555112
150Exercise-induced muscle cramps (HP:0003710)1.80479998
151Hyperkalemia (HP:0002153)1.79645420
152Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.78061764
153Complement deficiency (HP:0004431)1.77734239
154Anxiety (HP:0000739)1.77388682
155Rimmed vacuoles (HP:0003805)1.77212215
156Split foot (HP:0001839)1.76979070
157Abnormal respiratory motile cilium morphology (HP:0005938)1.76922780
158Abnormal respiratory epithelium morphology (HP:0012253)1.76922780
159Muscle stiffness (HP:0003552)1.76823400
160Ventricular arrhythmia (HP:0004308)1.73915456
161Increased variability in muscle fiber diameter (HP:0003557)1.73545702
162Neuroendocrine neoplasm (HP:0100634)1.72932186
163Distal lower limb muscle weakness (HP:0009053)1.72332300
164Patchy hypopigmentation of hair (HP:0011365)1.72113262
165Abnormality of the parathyroid morphology (HP:0011766)1.71754159
166White forelock (HP:0002211)1.70860742
167Increased intramyocellular lipid droplets (HP:0012240)1.70347604
168Abnormality of renin-angiotensin system (HP:0000847)1.69844964
169Abnormal hair whorl (HP:0010721)1.68845073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE17.48644601
2KDR3.80704177
3TNIK2.64713997
4STK392.64247058
5CASK2.39448398
6MYLK2.18338282
7OXSR12.16238471
8MUSK2.08548983
9GRK72.01033469
10EPHB11.87920465
11GRK11.78802155
12PHKG21.74102829
13PHKG11.74102829
14PKN11.71101376
15WNK41.68619543
16EPHB21.68027477
17RIPK11.66325557
18TGFBR21.56044975
19PRPF4B1.51076825
20INSRR1.50620873
21FRK1.48828630
22PTK2B1.43755053
23OBSCN1.41913069
24BCR1.31809008
25EPHA41.30501857
26MARK11.25450195
27MAPK131.22204568
28EPHA31.20322436
29ADRBK21.18443633
30PNCK1.18380836
31MAPKAPK31.15416100
32BMPR1B1.14536837
33PRKCE1.14138115
34AKT31.09753933
35ZAK1.09470110
36MAPK151.06218023
37MAP3K71.05933638
38CAMK2A1.03993382
39CAMK2D1.02186529
40MAP2K70.99570652
41PINK10.98028985
42DMPK0.97686362
43UHMK10.97030591
44IRAK20.96102366
45PAK30.93498342
46NEK60.92488478
47FES0.92155402
48ROCK20.87985308
49SGK2230.87205836
50SGK4940.87205836
51TRPM70.86502121
52NTRK20.86298940
53MAP3K60.85428274
54CAMK2B0.84303746
55PRKD10.84263025
56FGFR20.84028534
57TTN0.83134987
58MAPK120.81658613
59IRAK10.80814653
60WNK10.79268165
61CSNK1G30.76860999
62YES10.74950026
63PTK20.74696383
64GRK50.74131451
65MAPKAPK50.73462643
66NTRK30.72654514
67NTRK10.72153584
68NME10.71335360
69SIK30.70576452
70CLK10.70514876
71CSK0.70015363
72SIK20.68278834
73FER0.67123769
74NLK0.66923484
75CSNK1G10.64387173
76WNK30.63257345
77ROCK10.61491345
78CSNK1A1L0.60700999
79BMPR20.60688287
80PRKD30.60425042
81PIK3CA0.59660995
82TGFBR10.58972709
83PRKAA10.58353433
84MARK30.58247421
85RPS6KA20.58128758
86CAMK2G0.57791499
87MARK20.57523064
88PRKAA20.57215360
89MET0.56609809
90PRKACA0.56513842
91PDK20.55522323
92CDC42BPA0.53568918
93ADRBK10.52879976
94MAPK40.51203703
95PRKG10.51103915
96MAP3K110.49252688
97MAPK70.48555320
98CSNK1G20.48300157
99TNK20.45802813
100CAMK40.45759809
101PRKCH0.45484883
102EIF2AK20.44729101
103LIMK10.44662952
104DAPK20.44397866
105CAMK10.44038662
106CDK50.44036826
107LMTK20.43764406
108IRAK30.43743396
109PDGFRA0.43405716
110TEC0.43207203
111DYRK20.41985799
112SGK20.41885982
113FLT30.41623642
114ZAP700.41486073
115ABL20.41420433
116KIT0.41173400
117MAP4K20.41095335
118MAP3K120.40515760
119PRKD20.40390739
120IGF1R0.40029224
121MAP2K40.39582471
122PRKCQ0.38300999
123FGR0.37022902
124STK110.36586533
125PRKACB0.36429775
126PRKG20.36327548
127MAP3K40.36274194
128SGK10.34843070
129STK160.34807565
130ITK0.34222558
131EEF2K0.32821173
132PDGFRB0.32250137
133STK100.31852749
134MAP4K10.31777100
135PIK3CG0.30941230
136GSK3A0.30800945
137BCKDK0.29981012
138MAP3K10.29598379
139MAP2K60.28565005
140TESK10.28283231
141MAP2K30.28107838
142MAP3K130.28054508
143RPS6KA60.27939713
144SRC0.27381397
145MOS0.26940360
146PTK60.26064458
147FGFR40.25657408
148PRKACG0.23836436
149RPS6KC10.22970811
150RPS6KL10.22970811

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.88041404
2Parkinsons disease_Homo sapiens_hsa050123.31827848
3Cardiac muscle contraction_Homo sapiens_hsa042603.06664056
4Alzheimers disease_Homo sapiens_hsa050102.67235203
5Fatty acid elongation_Homo sapiens_hsa000622.58558189
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.53939913
7Dilated cardiomyopathy_Homo sapiens_hsa054142.25643710
8Huntingtons disease_Homo sapiens_hsa050162.17579179
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.07714116
10Nicotine addiction_Homo sapiens_hsa050332.05399332
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.04180990
12Taste transduction_Homo sapiens_hsa047421.93446054
13Morphine addiction_Homo sapiens_hsa050321.85143936
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71758494
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.71319209
16Serotonergic synapse_Homo sapiens_hsa047261.69373533
17Axon guidance_Homo sapiens_hsa043601.68916204
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67118356
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63756781
20Propanoate metabolism_Homo sapiens_hsa006401.59007412
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.58484981
22Glycerolipid metabolism_Homo sapiens_hsa005611.57788365
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57434602
24GABAergic synapse_Homo sapiens_hsa047271.56022292
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.55435076
26Notch signaling pathway_Homo sapiens_hsa043301.50746248
27Complement and coagulation cascades_Homo sapiens_hsa046101.45563101
28Glutamatergic synapse_Homo sapiens_hsa047241.44633669
29Circadian entrainment_Homo sapiens_hsa047131.35999434
30Ovarian steroidogenesis_Homo sapiens_hsa049131.32094664
31Renin secretion_Homo sapiens_hsa049241.30682550
32Calcium signaling pathway_Homo sapiens_hsa040201.28102359
33Ether lipid metabolism_Homo sapiens_hsa005651.27791968
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.25680895
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25644398
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19967544
37Arginine biosynthesis_Homo sapiens_hsa002201.19910682
38Butanoate metabolism_Homo sapiens_hsa006501.17441207
39Cocaine addiction_Homo sapiens_hsa050301.14490769
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12275459
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.10419653
42Fat digestion and absorption_Homo sapiens_hsa049751.09719519
43AMPK signaling pathway_Homo sapiens_hsa041521.08557248
44Arginine and proline metabolism_Homo sapiens_hsa003301.07248165
45Collecting duct acid secretion_Homo sapiens_hsa049661.06112122
46ECM-receptor interaction_Homo sapiens_hsa045121.05627100
47Insulin resistance_Homo sapiens_hsa049311.05463142
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04403493
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04170562
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01990839
51Dorso-ventral axis formation_Homo sapiens_hsa043201.00478800
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.99687241
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98132128
54cAMP signaling pathway_Homo sapiens_hsa040240.97298639
55Fatty acid metabolism_Homo sapiens_hsa012120.96636079
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.92429093
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91378613
58Cholinergic synapse_Homo sapiens_hsa047250.90862328
59Salivary secretion_Homo sapiens_hsa049700.90647319
60Insulin secretion_Homo sapiens_hsa049110.90445167
61Malaria_Homo sapiens_hsa051440.87156573
62Long-term depression_Homo sapiens_hsa047300.86547976
63beta-Alanine metabolism_Homo sapiens_hsa004100.84871741
64Oxytocin signaling pathway_Homo sapiens_hsa049210.84563709
65Ras signaling pathway_Homo sapiens_hsa040140.82780773
66Amphetamine addiction_Homo sapiens_hsa050310.82640578
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82054550
68Linoleic acid metabolism_Homo sapiens_hsa005910.81711893
69Olfactory transduction_Homo sapiens_hsa047400.81215347
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81093490
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80915068
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79612794
73Rheumatoid arthritis_Homo sapiens_hsa053230.78907115
74Phototransduction_Homo sapiens_hsa047440.78884135
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78834119
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77281636
77Gastric acid secretion_Homo sapiens_hsa049710.76122520
78Glucagon signaling pathway_Homo sapiens_hsa049220.75783387
79Sphingolipid metabolism_Homo sapiens_hsa006000.75744836
80Platelet activation_Homo sapiens_hsa046110.74473893
81Fatty acid degradation_Homo sapiens_hsa000710.73856765
82Histidine metabolism_Homo sapiens_hsa003400.73539196
83Arachidonic acid metabolism_Homo sapiens_hsa005900.71519831
84Bile secretion_Homo sapiens_hsa049760.70452243
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70165571
86Gap junction_Homo sapiens_hsa045400.69400593
87Adherens junction_Homo sapiens_hsa045200.68211432
88Insulin signaling pathway_Homo sapiens_hsa049100.68078541
89Synaptic vesicle cycle_Homo sapiens_hsa047210.67838929
90Tyrosine metabolism_Homo sapiens_hsa003500.67159267
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66689887
92Steroid biosynthesis_Homo sapiens_hsa001000.65798819
93Protein digestion and absorption_Homo sapiens_hsa049740.65314842
94Tryptophan metabolism_Homo sapiens_hsa003800.64924246
95Nitrogen metabolism_Homo sapiens_hsa009100.64783786
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64605774
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63118023
98Dopaminergic synapse_Homo sapiens_hsa047280.63044957
99Retinol metabolism_Homo sapiens_hsa008300.61135799
100Rap1 signaling pathway_Homo sapiens_hsa040150.59277222
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58707290
102Pyruvate metabolism_Homo sapiens_hsa006200.57396501
103Tight junction_Homo sapiens_hsa045300.56772174
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56669688
105Vibrio cholerae infection_Homo sapiens_hsa051100.55494407
106Protein export_Homo sapiens_hsa030600.55444849
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54450104
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.53900600
109Phenylalanine metabolism_Homo sapiens_hsa003600.52441921
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52248015
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52053020
112Peroxisome_Homo sapiens_hsa041460.50877864
113Regulation of autophagy_Homo sapiens_hsa041400.50510986
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50508615
115African trypanosomiasis_Homo sapiens_hsa051430.50488840
116Amoebiasis_Homo sapiens_hsa051460.50167382
117Focal adhesion_Homo sapiens_hsa045100.47862182
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47662824
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.47242980
120Melanogenesis_Homo sapiens_hsa049160.46980378
121Chemical carcinogenesis_Homo sapiens_hsa052040.46384861
122Pertussis_Homo sapiens_hsa051330.46157978
123ABC transporters_Homo sapiens_hsa020100.45698873
124PPAR signaling pathway_Homo sapiens_hsa033200.43695473
125TGF-beta signaling pathway_Homo sapiens_hsa043500.43072700
126Autoimmune thyroid disease_Homo sapiens_hsa053200.42975965
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42145580
128VEGF signaling pathway_Homo sapiens_hsa043700.41519805
129Circadian rhythm_Homo sapiens_hsa047100.41316894
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39792488
131Metabolic pathways_Homo sapiens_hsa011000.37369289
132GnRH signaling pathway_Homo sapiens_hsa049120.36162850
133Viral myocarditis_Homo sapiens_hsa054160.34932463
134Renal cell carcinoma_Homo sapiens_hsa052110.34901411
135Pancreatic secretion_Homo sapiens_hsa049720.33981374
136MAPK signaling pathway_Homo sapiens_hsa040100.31350592

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