ARHGEF16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal epithelial cell development (GO:0060576)6.98040242
2intestinal absorption (GO:0050892)6.42061218
3Golgi transport vesicle coating (GO:0048200)5.97417975
4COPI coating of Golgi vesicle (GO:0048205)5.97417975
5intestinal cholesterol absorption (GO:0030299)5.81677488
6bundle of His cell to Purkinje myocyte communication (GO:0086069)5.10039472
7proline biosynthetic process (GO:0006561)4.80272070
8glandular epithelial cell differentiation (GO:0002067)4.49969421
9UDP-N-acetylglucosamine metabolic process (GO:0006047)4.44651446
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.44314832
11proline metabolic process (GO:0006560)4.31548203
12angiotensin maturation (GO:0002003)4.27584432
13urea cycle (GO:0000050)4.19554876
14renal absorption (GO:0070293)4.16903329
15protein retention in ER lumen (GO:0006621)4.15832076
16COPII vesicle coating (GO:0048208)4.13065556
17endocrine pancreas development (GO:0031018)4.12738703
18modified amino acid transport (GO:0072337)4.11120421
19peptide catabolic process (GO:0043171)4.07496563
20columnar/cuboidal epithelial cell development (GO:0002066)4.00351604
21hemidesmosome assembly (GO:0031581)3.96899174
22drug transmembrane transport (GO:0006855)3.95611082
23desmosome organization (GO:0002934)3.95331368
24glomerular visceral epithelial cell development (GO:0072015)3.91306744
25urea metabolic process (GO:0019627)3.88922615
26peptide hormone processing (GO:0016486)3.88036376
27transcytosis (GO:0045056)3.86304404
28regulation of cholesterol biosynthetic process (GO:0045540)3.78095801
29interferon-gamma secretion (GO:0072643)3.75354473
303-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.73985140
31purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.73985140
32digestion (GO:0007586)3.73689562
33regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.66177930
34very-low-density lipoprotein particle assembly (GO:0034379)3.63789354
35negative regulation of keratinocyte proliferation (GO:0010839)3.63207904
36regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.61483958
37drug transport (GO:0015893)3.59842115
38calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.59351744
39glutamine family amino acid biosynthetic process (GO:0009084)3.57680270
40retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.57192265
41digestive system process (GO:0022600)3.57099015
42drug catabolic process (GO:0042737)3.51912216
43regulation of cholesterol metabolic process (GO:0090181)3.51035974
44regulation of cholesterol homeostasis (GO:2000188)3.50070906
45tight junction assembly (GO:0070830)3.47817973
46branching involved in mammary gland duct morphogenesis (GO:0060444)3.46455712
47vitamin transport (GO:0051180)3.46409778
48maintenance of gastrointestinal epithelium (GO:0030277)3.43223509
49plasma lipoprotein particle assembly (GO:0034377)3.41585099
50urate metabolic process (GO:0046415)3.41382345
51glomerular epithelial cell development (GO:0072310)3.39134740
52nitrogen cycle metabolic process (GO:0071941)3.35066926
53regulation of water loss via skin (GO:0033561)3.25622814
54sulfur compound transport (GO:0072348)3.24088813
55cysteine metabolic process (GO:0006534)3.23312699
56epithelial cell-cell adhesion (GO:0090136)3.17356114
57citrulline biosynthetic process (GO:0019240)3.16399200
58establishment of apical/basal cell polarity (GO:0035089)3.13596576
59gap junction assembly (GO:0016264)3.13572987
60fructose metabolic process (GO:0006000)3.12986549
61citrulline metabolic process (GO:0000052)3.12963783
62excretion (GO:0007588)3.11666511
63cell-cell junction maintenance (GO:0045217)3.11507203
64nucleotide-sugar biosynthetic process (GO:0009226)3.11197593
65sulfur amino acid catabolic process (GO:0000098)3.09487747
66trophectodermal cell differentiation (GO:0001829)3.09164026
67cellular response to hepatocyte growth factor stimulus (GO:0035729)3.08623576
68response to hepatocyte growth factor (GO:0035728)3.08623576
69vitamin transmembrane transport (GO:0035461)3.08326184
70activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.07686114
71apoptotic process involved in morphogenesis (GO:0060561)3.06086610
72diacylglycerol metabolic process (GO:0046339)3.04182950
73lung epithelium development (GO:0060428)3.04133861
74exocrine pancreas development (GO:0031017)3.04124784
75hormone catabolic process (GO:0042447)3.03944079
76protein-lipid complex assembly (GO:0065005)3.00850569
77regulation of bile acid biosynthetic process (GO:0070857)2.99308598
78bile acid and bile salt transport (GO:0015721)2.98865520
79epoxygenase P450 pathway (GO:0019373)2.98132597
80regulation of guanylate cyclase activity (GO:0031282)2.97586880
81cellular response to vitamin D (GO:0071305)2.97000997
82regulation of cardioblast differentiation (GO:0051890)2.95974693
83folic acid metabolic process (GO:0046655)2.94075091
84positive regulation of nuclease activity (GO:0032075)2.94032296
85renal system process involved in regulation of blood volume (GO:0001977)2.93281835
86GDP-mannose metabolic process (GO:0019673)2.91588242
87NADH metabolic process (GO:0006734)2.90396337
88multicellular organismal water homeostasis (GO:0050891)2.90300065
89protein autoprocessing (GO:0016540)2.88174158
904-hydroxyproline metabolic process (GO:0019471)2.87181549
91response to food (GO:0032094)2.86448178
92flavonoid metabolic process (GO:0009812)2.84804966
93negative regulation of digestive system process (GO:0060457)2.84551615
94phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.83673943
95planar cell polarity pathway involved in neural tube closure (GO:0090179)2.83156574
96positive regulation of epidermal cell differentiation (GO:0045606)2.82095088
97atrioventricular valve morphogenesis (GO:0003181)2.81164360
98regulation of apoptotic process involved in morphogenesis (GO:1902337)2.80097006
99ventricular cardiac muscle cell action potential (GO:0086005)2.80082336
100glomerular basement membrane development (GO:0032836)2.79951673
101epithelial structure maintenance (GO:0010669)2.77932785
102fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.77281934
103regulation of nuclease activity (GO:0032069)2.76603747
104diol metabolic process (GO:0034311)2.76585925
105regulation of cholesterol esterification (GO:0010872)2.75955026
106semaphorin-plexin signaling pathway (GO:0071526)2.74276310
107establishment of skin barrier (GO:0061436)2.73297367
108thyroid hormone metabolic process (GO:0042403)2.73130639
109homocysteine metabolic process (GO:0050667)2.72114249
110renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.71920088
111folic acid transport (GO:0015884)2.71287861
112positive regulation of cellular amine metabolic process (GO:0033240)2.69897429
113O-glycan processing (GO:0016266)2.69526234
114glucose catabolic process (GO:0006007)2.68984818
115regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.66779783
116endocrine process (GO:0050886)2.66779783
117regulation of systemic arterial blood pressure by hormone (GO:0001990)2.66779783
118cellular glucuronidation (GO:0052695)2.66690569
119maternal placenta development (GO:0001893)2.66581005
120glutathione biosynthetic process (GO:0006750)2.65140694
121L-alpha-amino acid transmembrane transport (GO:1902475)2.65008795
122phosphate ion homeostasis (GO:0055062)2.64291476
123trivalent inorganic anion homeostasis (GO:0072506)2.64291476
124cell junction maintenance (GO:0034331)2.64229155
125positive regulation of p38MAPK cascade (GO:1900745)2.63548466
126regulation of systemic arterial blood pressure (GO:0003073)2.62452718
127cytoskeletal anchoring at plasma membrane (GO:0007016)2.61885126
128fat-soluble vitamin biosynthetic process (GO:0042362)2.60845925
129regulation of fatty acid beta-oxidation (GO:0031998)2.59888451
130water homeostasis (GO:0030104)2.59838254
131surfactant homeostasis (GO:0043129)2.59813288
132regulation of hippo signaling (GO:0035330)2.59627175
133glucuronate metabolic process (GO:0019585)2.58735249
134uronic acid metabolic process (GO:0006063)2.58735249
135endoplasmic reticulum unfolded protein response (GO:0030968)2.58444859
136adherens junction assembly (GO:0034333)2.57645071
137glucose 6-phosphate metabolic process (GO:0051156)2.57409522
138regulation of Golgi to plasma membrane protein transport (GO:0042996)2.57397901
139negative regulation of glycoprotein biosynthetic process (GO:0010561)2.56646714
140positive regulation of pseudopodium assembly (GO:0031274)2.56646002
141biotin metabolic process (GO:0006768)2.56298207
142regulation of transforming growth factor beta2 production (GO:0032909)2.56117801
143phosphate ion transport (GO:0006817)2.55443117
144vesicle coating (GO:0006901)2.55272880
145phospholipid efflux (GO:0033700)2.54142390
146positive regulation of glycoprotein metabolic process (GO:1903020)2.53990854
147negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.53714338
148zinc ion transport (GO:0006829)2.53468146
149branching involved in labyrinthine layer morphogenesis (GO:0060670)2.52486764
150cellular response to unfolded protein (GO:0034620)2.52123199
151sulfate transmembrane transport (GO:1902358)2.52052364
152receptor catabolic process (GO:0032801)2.51955437
153sphingosine metabolic process (GO:0006670)2.51430526
154establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.50278803
155receptor recycling (GO:0001881)2.49272329
156regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.49119930
157cell-substrate adherens junction assembly (GO:0007045)2.48619230
158focal adhesion assembly (GO:0048041)2.48619230
159positive regulation of fatty acid beta-oxidation (GO:0032000)2.48598844
160hepatocyte apoptotic process (GO:0097284)2.48301577
161long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.47412763
162lysine catabolic process (GO:0006554)2.47173422
163lysine metabolic process (GO:0006553)2.47173422
164embryonic process involved in female pregnancy (GO:0060136)2.46890736
165establishment or maintenance of bipolar cell polarity (GO:0061245)2.46870894
166establishment or maintenance of apical/basal cell polarity (GO:0035088)2.46870894
167negative regulation of cell size (GO:0045792)2.46432219
168regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.46351309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.07512473
2* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.40797665
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.34901845
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.10217107
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.84638621
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.80281771
7GATA4_25053715_ChIP-Seq_YYC3_Human2.75375781
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.65541539
9CDX2_20551321_ChIP-Seq_CACO-2_Human2.64973387
10* GATA6_25053715_ChIP-Seq_YYC3_Human2.59071361
11AR_21909140_ChIP-Seq_LNCAP_Human2.49184784
12* ESR2_21235772_ChIP-Seq_MCF-7_Human2.48846663
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.34458508
14* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.31935255
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.31076635
16ZNF263_19887448_ChIP-Seq_K562_Human2.19370068
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.18056452
18SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.15825788
19CLOCK_20551151_ChIP-Seq_293T_Human2.13401115
20SOX2_20726797_ChIP-Seq_SW620_Human2.04866943
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.00283282
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94544043
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.91672475
24ATF3_27146783_Chip-Seq_COLON_Human1.88955276
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.88443197
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.87639930
27ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.86785987
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.83893580
29* RACK7_27058665_Chip-Seq_MCF-7_Human1.79182099
30* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.78425593
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.75996465
32* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.75503388
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74375434
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73983037
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.73843596
36FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.72806840
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.72493863
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.71776795
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.71616470
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.70102146
41NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.68753977
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.67914918
43TET1_21451524_ChIP-Seq_MESCs_Mouse1.66254122
44RUNX1_27514584_Chip-Seq_MCF-7_Human1.65655470
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.64944202
46TCF3_18692474_ChIP-Seq_MEFs_Mouse1.55442123
47P68_20966046_ChIP-Seq_HELA_Human1.53188762
48TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.52912732
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.51589168
50EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.51559273
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.50636359
52FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.48847482
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48551954
54* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47299188
55* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44667047
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44474784
57GATA3_24758297_ChIP-Seq_MCF-7_Human1.42905109
58SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.42129370
59* SMC4_20622854_ChIP-Seq_HELA_Human1.40849060
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.40816867
61VDR_21846776_ChIP-Seq_THP-1_Human1.39399443
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38919842
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37232371
64* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35531282
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34850431
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34605732
67* KDM2B_26808549_Chip-Seq_K562_Human1.33831773
68FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.33065000
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31057738
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30214669
71FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.29270779
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28759733
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27693939
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27397560
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26973634
76TCF7_22412390_ChIP-Seq_EML_Mouse1.26840424
77CHD1_26751641_Chip-Seq_LNCaP_Human1.24576154
78* CTCF_27219007_Chip-Seq_Bcells_Human1.24185737
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22155654
80P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21649585
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21491251
82* SA1_27219007_Chip-Seq_ERYTHROID_Human1.20618478
83MYC_22102868_ChIP-Seq_BL_Human1.20136682
84* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16578897
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14752534
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13563917
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13563917
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12890649
89KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12890649
90KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12890649
91* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12784705
92GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.10544341
93* CREB1_26743006_Chip-Seq_LNCaP_Human1.10167786
94* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09218957
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08882192
96* KLF5_25053715_ChIP-Seq_YYC3_Human1.08156173
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07834100
98BCOR_27268052_Chip-Seq_Bcells_Human1.07706856
99FOXA2_19822575_ChIP-Seq_HepG2_Human1.06915706
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05216822
101HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04476038
102OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04399414
103GATA1_22025678_ChIP-Seq_K562_Human1.04350460
104TP53_22127205_ChIP-Seq_IMR90_Human1.03855308
105* HNF4A_19822575_ChIP-Seq_HepG2_Human1.03531481
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03093381
107RARB_24833708_ChIP-Seq_LIVER_Mouse1.02860585
108SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01452290
109ESR1_20079471_ChIP-ChIP_T-47D_Human1.01399055
110JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00631055
111* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99968482
112ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99205969
113TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98842126
114FOXA1_25552417_ChIP-Seq_VCAP_Human0.97972737
115KAP1_27257070_Chip-Seq_ESCs_Mouse0.95838073
116KDM2B_26808549_Chip-Seq_DND41_Human0.95829420
117DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95688722
118* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94386249
119PHF8_20622854_ChIP-Seq_HELA_Human0.93323453
120NANOG_18692474_ChIP-Seq_MEFs_Mouse0.93262924
121TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93123670
122SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92542373
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91434859
124* TP63_22573176_ChIP-Seq_HFKS_Human0.90687915
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90300559
126NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88553184
127FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88349962
128NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87205429
129PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84815133
130NANOG_21062744_ChIP-ChIP_HESCs_Human0.84684426
131TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.83268058
132* LXR_22292898_ChIP-Seq_THP-1_Human0.83018564
133PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82147586
134KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81351891
135RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81057167
136P300_27058665_Chip-Seq_ZR-75-30cells_Human0.80791024
137NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.80497048
138ELK1_22589737_ChIP-Seq_MCF10A_Human0.79413384
139SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78586619
140RARA_24833708_ChIP-Seq_LIVER_Mouse0.78375318

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.88188226
2MP0004264_abnormal_extraembryonic_tissu4.50817843
3MP0005360_urolithiasis3.96710932
4MP0000566_synostosis3.94508948
5MP0001666_abnormal_nutrient_absorption3.51262283
6MP0004043_abnormal_pH_regulation3.29966446
7MP0002139_abnormal_hepatobiliary_system2.66940952
8MP0009643_abnormal_urine_homeostasis2.39417268
9MP0000537_abnormal_urethra_morphology2.35583147
10MP0004019_abnormal_vitamin_homeostasis2.32083122
11MP0003283_abnormal_digestive_organ2.30864987
12MP0000462_abnormal_digestive_system2.22346883
13MP0000678_abnormal_parathyroid_gland2.19765663
14MP0005085_abnormal_gallbladder_physiolo2.18612676
15MP0005365_abnormal_bile_salt2.17751523
16MP0004858_abnormal_nervous_system2.14875326
17MP0003693_abnormal_embryo_hatching2.13090406
18MP0003252_abnormal_bile_duct2.07711518
19MP0009840_abnormal_foam_cell1.98927361
20MP0001756_abnormal_urination1.95113094
21MP0005332_abnormal_amino_acid1.94432348
22MP0002877_abnormal_melanocyte_morpholog1.94298100
23MP0005409_darkened_coat_color1.92321116
24MP0002796_impaired_skin_barrier1.81278254
25MP0009379_abnormal_foot_pigmentation1.79931891
26MP0002138_abnormal_hepatobiliary_system1.77686070
27MP0005220_abnormal_exocrine_pancreas1.74578475
28MP0001765_abnormal_ion_homeostasis1.67988161
29MP0002098_abnormal_vibrissa_morphology1.67711377
30MP0003300_gastrointestinal_ulcer1.67612739
31MP0005377_hearing/vestibular/ear_phenot1.63935003
32MP0003878_abnormal_ear_physiology1.63935003
33MP0003195_calcinosis1.61550793
34MP0010352_gastrointestinal_tract_polyps1.59981187
35MP0005670_abnormal_white_adipose1.58650063
36MP0003866_abnormal_defecation1.57399140
37MP0003183_abnormal_peptide_metabolism1.57390427
38MP0008875_abnormal_xenobiotic_pharmacok1.57319936
39MP0001944_abnormal_pancreas_morphology1.54417426
40MP0003941_abnormal_skin_development1.53240014
41MP0002693_abnormal_pancreas_physiology1.52813210
42MP0000538_abnormal_urinary_bladder1.52771687
43MP0002249_abnormal_larynx_morphology1.48964113
44MP0010678_abnormal_skin_adnexa1.47743250
45MP0003705_abnormal_hypodermis_morpholog1.46566710
46MP0002254_reproductive_system_inflammat1.46412512
47MP0002089_abnormal_postnatal_growth/wei1.46311986
48MP0001849_ear_inflammation1.45495949
49MP0005257_abnormal_intraocular_pressure1.37559482
50MP0005636_abnormal_mineral_homeostasis1.36706409
51MP0002136_abnormal_kidney_physiology1.36557892
52MP0003718_maternal_effect1.34784615
53MP0001664_abnormal_digestion1.32529400
54MP0000013_abnormal_adipose_tissue1.31179602
55MP0000477_abnormal_intestine_morphology1.25533717
56MP0005666_abnormal_adipose_tissue1.23850985
57MP0002909_abnormal_adrenal_gland1.21697445
58MP0005451_abnormal_body_composition1.19738086
59MP0005084_abnormal_gallbladder_morpholo1.19610973
60MP0003806_abnormal_nucleotide_metabolis1.17055837
61MP0004957_abnormal_blastocyst_morpholog1.16533931
62MP0000762_abnormal_tongue_morphology1.16000467
63MP0008004_abnormal_stomach_pH1.14928357
64MP0003315_abnormal_perineum_morphology1.11721295
65MP0009780_abnormal_chondrocyte_physiolo1.09888146
66MP0005367_renal/urinary_system_phenotyp1.08475217
67MP0000516_abnormal_urinary_system1.08475217
68MP0003453_abnormal_keratinocyte_physiol1.08253056
69MP0005501_abnormal_skin_physiology1.07584355
70MP0003868_abnormal_feces_composition1.07425813
71MP0010386_abnormal_urinary_bladder1.07269393
72MP0010329_abnormal_lipoprotein_level1.07231251
73MP0003119_abnormal_digestive_system1.05937416
74MP0000613_abnormal_salivary_gland1.05286423
75MP0008260_abnormal_autophagy1.04280970
76MP0002876_abnormal_thyroid_physiology1.03669531
77MP0001216_abnormal_epidermal_layer1.03151291
78MP0003879_abnormal_hair_cell1.02615365
79MP0005381_digestive/alimentary_phenotyp1.01858697
80MP0000490_abnormal_crypts_of1.00600713
81MP0002234_abnormal_pharynx_morphology0.99760755
82MP0006054_spinal_hemorrhage0.95660127
83MP0001873_stomach_inflammation0.95379275
84MP0003123_paternal_imprinting0.94200613
85MP0000470_abnormal_stomach_morphology0.93072291
86MP0004272_abnormal_basement_membrane0.92507976
87MP0002060_abnormal_skin_morphology0.92482412
88MP0003566_abnormal_cell_adhesion0.92457424
89MP0000579_abnormal_nail_morphology0.91915301
90MP0005310_abnormal_salivary_gland0.89871809
91MP0010771_integument_phenotype0.89623100
92MP0002896_abnormal_bone_mineralization0.88875501
93MP0004782_abnormal_surfactant_physiolog0.88599370
94MP0005375_adipose_tissue_phenotype0.86243303
95MP0000627_abnormal_mammary_gland0.86193639
96MP0009672_abnormal_birth_weight0.85798718
97MP0000003_abnormal_adipose_tissue0.85276020
98MP0000383_abnormal_hair_follicle0.84925582
99MP0002118_abnormal_lipid_homeostasis0.82866014
100MP0005083_abnormal_biliary_tract0.82521226
101MP0010155_abnormal_intestine_physiology0.81862008
102MP0002078_abnormal_glucose_homeostasis0.80932019
103MP0008961_abnormal_basal_metabolism0.80750552
104MP0000377_abnormal_hair_follicle0.79239741
105MP0001663_abnormal_digestive_system0.79157105
106MP0000467_abnormal_esophagus_morphology0.78246907
107MP0004185_abnormal_adipocyte_glucose0.77438690
108MP0002111_abnormal_tail_morphology0.76900929
109MP0005395_other_phenotype0.76559370
110MP0005076_abnormal_cell_differentiation0.76178932
111MP0000609_abnormal_liver_physiology0.75363379
112MP0001346_abnormal_lacrimal_gland0.75329726
113MP0002086_abnormal_extraembryonic_tissu0.74643937
114MP0001730_embryonic_growth_arrest0.74608378
115MP0009931_abnormal_skin_appearance0.73999310
116MP0005319_abnormal_enzyme/_coenzyme0.73859972
117MP0001881_abnormal_mammary_gland0.73594331
118MP0003191_abnormal_cellular_cholesterol0.73438378
119MP0005058_abnormal_lysosome_morphology0.73222825
120MP0005023_abnormal_wound_healing0.72503007
121MP0010030_abnormal_orbit_morphology0.69644795
122MP0001764_abnormal_homeostasis0.66882168
123MP0003115_abnormal_respiratory_system0.60549147
124MP0002697_abnormal_eye_size0.60498443
125MP0001672_abnormal_embryogenesis/_devel0.60233102
126MP0005380_embryogenesis_phenotype0.60233102
127MP0003984_embryonic_growth_retardation0.58777619
128MP0000858_altered_metastatic_potential0.56477947

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)5.13130993
2Gout (HP:0001997)4.90190153
3Abnormality of chloride homeostasis (HP:0011422)4.41341652
4Right ventricular cardiomyopathy (HP:0011663)4.13402838
5Abnormal pancreas size (HP:0012094)4.03065745
6Hyperglycinuria (HP:0003108)3.70087966
7Ileus (HP:0002595)3.68132452
8Hyperglycemia (HP:0003074)3.66552316
9Hemorrhage of the eye (HP:0011885)3.64699730
10Hypoglycemic coma (HP:0001325)3.56510428
11Metabolic alkalosis (HP:0200114)3.55657032
12Focal segmental glomerulosclerosis (HP:0000097)3.46769189
13Abnormality of renin-angiotensin system (HP:0000847)3.41125828
14Symptomatic seizures (HP:0011145)3.40847707
15Pili torti (HP:0003777)3.37336901
16Hypokalemic alkalosis (HP:0001949)3.31391927
17Abnormality of glutamine family amino acid metabolism (HP:0010902)3.28395839
18Increased circulating renin level (HP:0000848)3.26345929
19Hyperinsulinemic hypoglycemia (HP:0000825)3.26209726
20Abnormality of purine metabolism (HP:0004352)3.24109451
21Malnutrition (HP:0004395)3.22740046
22Hypoglycemic seizures (HP:0002173)3.20809918
23Abdominal distention (HP:0003270)3.20787441
24Glomerulosclerosis (HP:0000096)3.17523166
25Hypokalemia (HP:0002900)3.13153433
26Hyperuricemia (HP:0002149)3.06347926
27Increased purine levels (HP:0004368)3.06347926
28Late onset (HP:0003584)3.05749090
29Abnormal biliary tract morphology (HP:0012440)2.92134404
30Ketoacidosis (HP:0001993)2.91309917
31Renal salt wasting (HP:0000127)2.86860407
32Proximal tubulopathy (HP:0000114)2.81619118
33Abnormality of renal excretion (HP:0011036)2.78703854
34Hyperaldosteronism (HP:0000859)2.77528668
35Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.77038213
36Generalized aminoaciduria (HP:0002909)2.76658847
37Abnormality of magnesium homeostasis (HP:0004921)2.76158604
38Deep venous thrombosis (HP:0002625)2.73814098
39Abnormality of carpal bone ossification (HP:0006257)2.70129564
40Glycosuria (HP:0003076)2.67113147
41Abnormality of urine glucose concentration (HP:0011016)2.67113147
42Alkalosis (HP:0001948)2.64612794
43Insulin-resistant diabetes mellitus (HP:0000831)2.63208543
44Abnormality of glycine metabolism (HP:0010895)2.63184691
45Abnormality of serine family amino acid metabolism (HP:0010894)2.63184691
46Abnormality of small intestinal villus morphology (HP:0011472)2.60984210
47Villous atrophy (HP:0011473)2.60984210
48Hypomagnesemia (HP:0002917)2.60870931
49Abnormality of proline metabolism (HP:0010907)2.60763298
50Hydroxyprolinuria (HP:0003080)2.60763298
51Decreased circulating renin level (HP:0003351)2.57608763
52Abnormal urine output (HP:0012590)2.55896101
53Conjugated hyperbilirubinemia (HP:0002908)2.54881763
54Abnormal tarsal ossification (HP:0008369)2.54004840
55Pterygium (HP:0001059)2.53584156
56Tetany (HP:0001281)2.50243766
57Abnormality of potassium homeostasis (HP:0011042)2.47173712
58Broad face (HP:0000283)2.45876419
59Bronchomalacia (HP:0002780)2.44196122
60Stridor (HP:0010307)2.42679785
61Septate vagina (HP:0001153)2.40916674
62Fragile nails (HP:0001808)2.40828144
63Abnormal albumin level (HP:0012116)2.38679583
64Hypoalbuminemia (HP:0003073)2.38679583
65Distal upper limb amyotrophy (HP:0007149)2.38411370
66Upper limb amyotrophy (HP:0009129)2.38411370
67Polyuria (HP:0000103)2.38277878
68Milia (HP:0001056)2.33978792
69Unilateral renal agenesis (HP:0000122)2.33065170
70Biliary tract neoplasm (HP:0100574)2.31508526
71Abnormality of the distal phalanges of the toes (HP:0010182)2.31245352
72Dehydration (HP:0001944)2.30554568
73Abnormality of monocarboxylic acid metabolism (HP:0010996)2.30063529
74Xanthomatosis (HP:0000991)2.29889048
75Hypobetalipoproteinemia (HP:0003563)2.29818419
76Abnormality of nucleobase metabolism (HP:0010932)2.29733432
77Delayed epiphyseal ossification (HP:0002663)2.28525672
78Abnormality of the distal phalanx of the thumb (HP:0009617)2.28509558
79Hyperglycinemia (HP:0002154)2.26034785
80Onycholysis (HP:0001806)2.25111734
81Wide cranial sutures (HP:0010537)2.24817950
82Insulin resistance (HP:0000855)2.24684729
83Fat malabsorption (HP:0002630)2.24369029
84Abnormality of calcium-phosphate metabolism (HP:0100530)2.24036208
85Hyperphosphaturia (HP:0003109)2.22256864
86Abnormal ossification of hand bones (HP:0005921)2.21388808
87Hyperacusis (HP:0010780)2.19471522
88Widely patent fontanelles and sutures (HP:0004492)2.18440836
89Abnormality of endocrine pancreas physiology (HP:0012093)2.17968080
90Abnormality of the pancreatic islet cells (HP:0006476)2.17968080
91Potter facies (HP:0002009)2.17367402
92Facial shape deformation (HP:0011334)2.17367402
93Hyperparathyroidism (HP:0000843)2.17265740
94Advanced eruption of teeth (HP:0006288)2.16495623
95Distal lower limb amyotrophy (HP:0008944)2.14450312
96Mildly elevated creatine phosphokinase (HP:0008180)2.13614965
97Alopecia of scalp (HP:0002293)2.13509580
98Nephrolithiasis (HP:0000787)2.12549926
99Mesangial abnormality (HP:0001966)2.11760727
100Hypophosphatemia (HP:0002148)2.10351897
101Hypoplasia of the uterus (HP:0000013)2.08662772
102Aplasia/hypoplasia of the uterus (HP:0008684)2.07746833
103Ventricular fibrillation (HP:0001663)2.07595350
104Cervical subluxation (HP:0003308)2.06631728
105Partial duplication of thumb phalanx (HP:0009944)2.06382670
106Hypotension (HP:0002615)2.05212884
107Growth hormone excess (HP:0000845)2.04985126
108Intrahepatic cholestasis (HP:0001406)2.03797509
109Atrophic scars (HP:0001075)2.02229022
110Abnormal foot bone ossification (HP:0010675)2.01880983
111Abnormal hair laboratory examination (HP:0003328)2.00348936
112Spinal cord compression (HP:0002176)1.99559328
113Trismus (HP:0000211)1.98985269
114Abnormal hand bone ossification (HP:0010660)1.98850359
115Micronodular cirrhosis (HP:0001413)1.97560778
116Neonatal death (HP:0003811)1.97193689
117Hypoplasia of dental enamel (HP:0006297)1.97023893
118Thin bony cortex (HP:0002753)1.96904879
119Ketosis (HP:0001946)1.96340351
120Subcapsular cataract (HP:0000523)1.94245347
121J-shaped sella turcica (HP:0002680)1.93928247
122Hyperammonemia (HP:0001987)1.93813896
123Shawl scrotum (HP:0000049)1.92775438
124Diaphragmatic weakness (HP:0009113)1.91127541
125Woolly hair (HP:0002224)1.90239913
126Exocrine pancreatic insufficiency (HP:0001738)1.88955607
127Hypercalciuria (HP:0002150)1.88654723
128Abnormality of sulfur amino acid metabolism (HP:0004339)1.87932586
129Abnormality of the gastric mucosa (HP:0004295)1.87533061
130Flat acetabular roof (HP:0003180)1.87446008
131Pigmentary retinal degeneration (HP:0001146)1.86907109
132Abnormal urine phosphate concentration (HP:0012599)1.86266799
133Ulnar bowing (HP:0003031)1.84225496
134Hypercholesterolemia (HP:0003124)1.83417405
135Abnormality of the salivary glands (HP:0010286)1.83014800
136Fragile skin (HP:0001030)1.81974491
137Axonal loss (HP:0003447)1.80512797
138Ankyloglossia (HP:0010296)1.80417851
139Amelogenesis imperfecta (HP:0000705)1.78473567
140Acanthosis nigricans (HP:0000956)1.76558173
141Abnormality of the Achilles tendon (HP:0005109)1.75408487
142Selective tooth agenesis (HP:0001592)1.74706490
143Abnormal vertebral ossification (HP:0100569)1.73982893
144Germ cell neoplasia (HP:0100728)1.73890136
145Progressive sensorineural hearing impairment (HP:0000408)1.71986736
146Flattened epiphyses (HP:0003071)1.71700464
147Bifid scrotum (HP:0000048)1.71371134
148Vascular calcification (HP:0004934)1.71186828
149Hyponatremia (HP:0002902)1.70870777
150Myopathic facies (HP:0002058)1.70567039
151Abnormality of permanent molar morphology (HP:0011071)1.69618370
152Abnormality of the dental root (HP:0006486)1.69618370
153Taurodontia (HP:0000679)1.69618370
154Deviation of the thumb (HP:0009603)1.68949721
155Glomerulonephritis (HP:0000099)1.68146524
156Asymmetry of the thorax (HP:0001555)1.68089690
157Curly hair (HP:0002212)1.67906369
158Lymphangioma (HP:0100764)1.65334079
159Abnormality of alkaline phosphatase activity (HP:0004379)1.65313620
160Abnormality of pyrimidine metabolism (HP:0004353)1.65237678

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.24750993
2SIK13.87449615
3FRK3.85145180
4WNK43.38959949
5MST43.09839971
6SMG12.96524708
7MAP2K22.92585629
8WNK32.92574599
9LATS12.51823201
10STK38L2.41416546
11MST1R2.26678752
12ICK2.20896553
13INSRR2.14203720
14MAP3K22.12139796
15MAPK152.09625053
16ERN11.97676000
17AKT31.96726209
18MAP3K31.96048719
19TAOK31.94743689
20PRKCI1.83700047
21PASK1.82973436
22PTK61.79355807
23NME11.77340477
24PTK21.72414532
25RIPK11.70500476
26BCKDK1.54780997
27TTK1.52858953
28NME21.50077297
29EPHB21.47753232
30MET1.38829484
31NUAK11.32893073
32FER1.32739655
33OXSR11.31953281
34TRIB31.29221812
35PAK41.22439030
36CDK121.22062530
37TSSK61.20718907
38TAOK11.14226187
39RPS6KB21.12511285
40BUB11.05945626
41PRKG21.04292939
42SCYL21.00831599
43TESK21.00431118
44BMX0.98744284
45STK100.98401615
46PBK0.97362960
47PDK20.96379972
48MAP3K80.95712854
49BRAF0.94805847
50BRSK20.94072509
51MAP2K10.93881809
52LMTK20.91002316
53FGFR40.88157063
54STK390.87249848
55IRAK30.85585896
56MAP3K10.85423269
57LATS20.82755015
58CDK70.82533607
59PIK3CA0.82419805
60MELK0.79104143
61STK30.78838815
62EIF2AK30.78374876
63PDK40.75071352
64PDK30.75071352
65MAPKAPK30.73879127
66AURKB0.71866986
67TESK10.70635409
68PRKD30.70581446
69WEE10.69938762
70IRAK20.69282981
71MAP3K90.68784531
72NLK0.68335244
73PRKD20.65568864
74CAMK1D0.64287055
75NEK10.63980202
76DYRK1B0.63102911
77LRRK20.62547503
78ERBB40.62526780
79MUSK0.60409168
80PLK40.59430915
81ACVR1B0.58785790
82ARAF0.58407739
83CDC42BPA0.57991001
84MTOR0.57563010
85DDR20.57509274
86ERBB20.55744670
87PRPF4B0.55270126
88PRKAA10.54184127
89MYLK0.54093165
90FGFR30.52189651
91STK240.51176578
92RPS6KA20.50923513
93NEK60.50584683
94MAP2K30.50007481
95EPHB10.47881269
96NEK20.47413726
97GSK3A0.46326030
98HIPK20.46298662
99PDGFRA0.46198704
100KSR20.44132878
101RPS6KA40.43994915
102MAP3K70.43515482
103MARK20.42255611
104PAK30.41940629
105MAP3K60.41481036
106MAP2K60.41053163
107MAP3K100.40996511
108MAPK110.40188764
109DYRK30.40035482
110CHUK0.39990216
111ILK0.39502812
112ZAK0.38117565
113FGFR10.37090987
114MAP3K110.36864518
115EPHA30.36398591
116PLK10.36318562
117TYRO30.36314201
118CDK90.35397794
119GRK60.34484509
120CSNK1A10.33743962
121AURKA0.33404953
122AKT20.32962143
123STK380.32525029
124NTRK10.31972137
125PDPK10.31938009
126RET0.31222499
127EEF2K0.30866296
128PIM20.30851099
129CDK80.30785932
130CSNK1E0.29304475
131RPS6KC10.29294543
132RPS6KL10.29294543
133MAP3K120.29284322
134PRKAA20.29154987
135MATK0.27615627
136CAMK2G0.26690213
137DAPK10.26157941
138PAK10.25588748
139CHEK20.24574952
140PKN20.24193233

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.75137357
2Sulfur metabolism_Homo sapiens_hsa009203.47047299
3Fat digestion and absorption_Homo sapiens_hsa049753.39402859
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.01172993
5Vitamin digestion and absorption_Homo sapiens_hsa049772.72685465
6Folate biosynthesis_Homo sapiens_hsa007902.49782640
7Mineral absorption_Homo sapiens_hsa049782.34933180
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.25067455
9Renin-angiotensin system_Homo sapiens_hsa046142.21272960
10Protein digestion and absorption_Homo sapiens_hsa049742.16664537
11Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.94339747
12Galactose metabolism_Homo sapiens_hsa000521.86007408
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.80788801
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.77543108
15Selenocompound metabolism_Homo sapiens_hsa004501.69061621
16Fatty acid biosynthesis_Homo sapiens_hsa000611.68012354
17Protein export_Homo sapiens_hsa030601.67911056
18Fructose and mannose metabolism_Homo sapiens_hsa000511.62896909
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.57313234
20Histidine metabolism_Homo sapiens_hsa003401.53542748
21Tryptophan metabolism_Homo sapiens_hsa003801.51823500
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.46304106
23Starch and sucrose metabolism_Homo sapiens_hsa005001.46169860
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44495135
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44039699
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40444944
27Glutathione metabolism_Homo sapiens_hsa004801.38014037
28Pancreatic secretion_Homo sapiens_hsa049721.36954091
29Bile secretion_Homo sapiens_hsa049761.36950330
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36643121
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30503959
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29776033
33Butanoate metabolism_Homo sapiens_hsa006501.24628742
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23769803
35Fatty acid degradation_Homo sapiens_hsa000711.21585086
36Linoleic acid metabolism_Homo sapiens_hsa005911.21410918
37Vitamin B6 metabolism_Homo sapiens_hsa007501.20962494
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17201101
39Tight junction_Homo sapiens_hsa045301.16847962
40Glycerolipid metabolism_Homo sapiens_hsa005611.12318104
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10171244
42Notch signaling pathway_Homo sapiens_hsa043301.08154328
43Arginine and proline metabolism_Homo sapiens_hsa003301.08015326
44Other glycan degradation_Homo sapiens_hsa005111.06908370
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.04118636
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.02005929
47Caffeine metabolism_Homo sapiens_hsa002320.99216117
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98962451
49beta-Alanine metabolism_Homo sapiens_hsa004100.95437638
50Sphingolipid metabolism_Homo sapiens_hsa006000.94174868
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92987193
52Regulation of autophagy_Homo sapiens_hsa041400.91167881
53N-Glycan biosynthesis_Homo sapiens_hsa005100.90076097
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.89224124
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88499853
56Thyroid hormone synthesis_Homo sapiens_hsa049180.87061275
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84389939
58Bladder cancer_Homo sapiens_hsa052190.83503741
59Pyruvate metabolism_Homo sapiens_hsa006200.83264199
60AMPK signaling pathway_Homo sapiens_hsa041520.81624534
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80120348
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79561425
63Vibrio cholerae infection_Homo sapiens_hsa051100.78263541
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77276858
65Arachidonic acid metabolism_Homo sapiens_hsa005900.75796000
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73186754
67Adherens junction_Homo sapiens_hsa045200.72349564
68Carbon metabolism_Homo sapiens_hsa012000.71699310
69Insulin signaling pathway_Homo sapiens_hsa049100.70641111
70Peroxisome_Homo sapiens_hsa041460.69180109
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68577467
72Insulin secretion_Homo sapiens_hsa049110.68507431
73ABC transporters_Homo sapiens_hsa020100.67091277
74Circadian rhythm_Homo sapiens_hsa047100.65519806
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64644824
76Phenylalanine metabolism_Homo sapiens_hsa003600.64571528
77Propanoate metabolism_Homo sapiens_hsa006400.64117502
78Lysosome_Homo sapiens_hsa041420.62992742
79Pentose phosphate pathway_Homo sapiens_hsa000300.62496208
80Glucagon signaling pathway_Homo sapiens_hsa049220.62428345
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.60875288
82PPAR signaling pathway_Homo sapiens_hsa033200.60613246
83Thyroid cancer_Homo sapiens_hsa052160.58380572
84Chemical carcinogenesis_Homo sapiens_hsa052040.58340359
85Hippo signaling pathway_Homo sapiens_hsa043900.55880126
86Fatty acid elongation_Homo sapiens_hsa000620.53847749
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50577804
88Steroid biosynthesis_Homo sapiens_hsa001000.49945408
89Arginine biosynthesis_Homo sapiens_hsa002200.49015460
90Insulin resistance_Homo sapiens_hsa049310.48685566
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47833577
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.47624755
93Metabolic pathways_Homo sapiens_hsa011000.46667092
94Type II diabetes mellitus_Homo sapiens_hsa049300.46099130
95Retinol metabolism_Homo sapiens_hsa008300.45646578
96Lysine degradation_Homo sapiens_hsa003100.42699694
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.40061266
98Small cell lung cancer_Homo sapiens_hsa052220.37936836
99Complement and coagulation cascades_Homo sapiens_hsa046100.37855134
100Endometrial cancer_Homo sapiens_hsa052130.37690622
101Sulfur relay system_Homo sapiens_hsa041220.37297827
102Biosynthesis of amino acids_Homo sapiens_hsa012300.36255286
103Base excision repair_Homo sapiens_hsa034100.35729271
104Chronic myeloid leukemia_Homo sapiens_hsa052200.34605737
105Fatty acid metabolism_Homo sapiens_hsa012120.34385277
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33925257
107ECM-receptor interaction_Homo sapiens_hsa045120.31378447
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.30324013
109Hepatitis C_Homo sapiens_hsa051600.29985679
110RNA polymerase_Homo sapiens_hsa030200.29978254
111Basal cell carcinoma_Homo sapiens_hsa052170.29029302
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27634189
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27260601
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.26573050
115Tyrosine metabolism_Homo sapiens_hsa003500.22707653
116Antigen processing and presentation_Homo sapiens_hsa046120.21770036
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21273037
118p53 signaling pathway_Homo sapiens_hsa041150.20914678
119Inositol phosphate metabolism_Homo sapiens_hsa005620.18839292
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.17732449
121Pyrimidine metabolism_Homo sapiens_hsa002400.16189169

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