ARHGEF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.71940057
2positive regulation of gamma-delta T cell activation (GO:0046645)4.67793129
3response to peptidoglycan (GO:0032494)4.21214164
4positive regulation by symbiont of host defense response (GO:0052509)4.10310470
5modulation by symbiont of host defense response (GO:0052031)4.10310470
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.10310470
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.10310470
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.10310470
9modulation by symbiont of host immune response (GO:0052553)4.10310470
10macrophage activation involved in immune response (GO:0002281)3.78880502
11axon ensheathment in central nervous system (GO:0032291)3.76163673
12central nervous system myelination (GO:0022010)3.76163673
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.70144938
14antigen processing and presentation of endogenous antigen (GO:0019883)3.56266213
15germinal center formation (GO:0002467)3.55908454
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.52992458
17negative regulation of interleukin-12 production (GO:0032695)3.52409700
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.49644470
19mannose metabolic process (GO:0006013)3.40128374
20detection of other organism (GO:0098543)3.36550977
21regulation of gamma-delta T cell activation (GO:0046643)3.33794288
22cellular extravasation (GO:0045123)3.26672735
23lipopolysaccharide-mediated signaling pathway (GO:0031663)3.24742761
24neutrophil activation involved in immune response (GO:0002283)3.24201962
25detection of bacterium (GO:0016045)3.17458692
26regulation of interferon-beta biosynthetic process (GO:0045357)3.11297764
27* response to muramyl dipeptide (GO:0032495)3.09911728
28ensheathment of neurons (GO:0007272)3.09808537
29axon ensheathment (GO:0008366)3.09808537
30myelination (GO:0042552)3.06392179
31maintenance of protein location in nucleus (GO:0051457)3.04841120
32regulation of T-helper 2 cell differentiation (GO:0045628)3.04407807
33cortical actin cytoskeleton organization (GO:0030866)3.04324384
34regulation of B cell receptor signaling pathway (GO:0050855)3.03246208
35detection of molecule of bacterial origin (GO:0032490)3.02703272
36nerve growth factor signaling pathway (GO:0038180)3.02425072
37regulation of leukocyte degranulation (GO:0043300)3.02231926
38detection of external biotic stimulus (GO:0098581)2.96698099
39regulation of gamma-delta T cell differentiation (GO:0045586)2.96229162
40regulation of mast cell degranulation (GO:0043304)2.94851373
41positive regulation of histone deacetylation (GO:0031065)2.94181201
42leukocyte aggregation (GO:0070486)2.93560557
43microtubule severing (GO:0051013)2.91564839
44NIK/NF-kappaB signaling (GO:0038061)2.91209581
45positive thymic T cell selection (GO:0045059)2.90956277
46positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.88610706
47immunoglobulin mediated immune response (GO:0016064)2.85918333
48positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.84656503
49positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.84594941
50regulation of myeloid leukocyte mediated immunity (GO:0002886)2.84115900
51histone H4-K8 acetylation (GO:0043982)2.79526434
52histone H4-K5 acetylation (GO:0043981)2.79526434
53positive regulation of B cell differentiation (GO:0045579)2.76237331
54positive regulation of Rap GTPase activity (GO:0032854)2.72864222
55type I interferon signaling pathway (GO:0060337)2.71989829
56cellular response to type I interferon (GO:0071357)2.71989829
57response to type I interferon (GO:0034340)2.71576392
58response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.68368273
59response to host (GO:0075136)2.68368273
60response to host defenses (GO:0052200)2.68368273
61barbed-end actin filament capping (GO:0051016)2.68296552
62cortical cytoskeleton organization (GO:0030865)2.67238354
63negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.67128435
64positive regulation of cellular amide metabolic process (GO:0034250)2.66680711
65response to host immune response (GO:0052572)2.66593547
66response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.66593547
67histone H4-K16 acetylation (GO:0043984)2.64320472
68myeloid cell activation involved in immune response (GO:0002275)2.63919635
69regulation of type I interferon-mediated signaling pathway (GO:0060338)2.63817989
70positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.63457046
71regulation of mast cell activation involved in immune response (GO:0033006)2.62745355
72detection of biotic stimulus (GO:0009595)2.62096758
73positive regulation of protein deacetylation (GO:0090312)2.60534766
74pinocytosis (GO:0006907)2.60440574
75regulation of Rap GTPase activity (GO:0032317)2.59762354
76Rap protein signal transduction (GO:0032486)2.59506155
77myeloid dendritic cell differentiation (GO:0043011)2.57620771
78modulation by symbiont of host cellular process (GO:0044068)2.56665564
79T cell migration (GO:0072678)2.56240628
80interferon-gamma-mediated signaling pathway (GO:0060333)2.56071264
81regulation of dendritic cell antigen processing and presentation (GO:0002604)2.55482807
82regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.55438780
83macrophage activation (GO:0042116)2.54957704
84negative regulation of leukocyte mediated immunity (GO:0002704)2.54409718
85cellular response to thyroid hormone stimulus (GO:0097067)2.53597286
86regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.53094074
87positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.52920701
88defense response to protozoan (GO:0042832)2.51010634
89regulation of regulated secretory pathway (GO:1903305)2.50762904
90myelin maintenance (GO:0043217)2.49165844
91histone H3-K4 trimethylation (GO:0080182)2.48276687
92regulation of vitamin D biosynthetic process (GO:0060556)2.47897860
93response to protozoan (GO:0001562)2.47544168
94negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.47052560
95negative regulation of lymphocyte mediated immunity (GO:0002707)2.45286780
96negative thymic T cell selection (GO:0045060)2.44882896
97thymic T cell selection (GO:0045061)2.44840745
98heterochromatin organization (GO:0070828)2.44469430
99negative regulation of cytokine production involved in immune response (GO:0002719)2.44447746
100negative regulation of T cell mediated immunity (GO:0002710)2.44330931
101regulation of type 2 immune response (GO:0002828)2.43138182
102megakaryocyte development (GO:0035855)2.43129831
103cytoskeletal anchoring at plasma membrane (GO:0007016)2.42905981
104negative regulation of toll-like receptor signaling pathway (GO:0034122)2.42667580
105negative regulation of type 2 immune response (GO:0002829)2.41992715
106regulation of ARF GTPase activity (GO:0032312)2.41155828
107histone H4-K12 acetylation (GO:0043983)2.40966930
108positive regulation of type 2 immune response (GO:0002830)2.40929478
109negative regulation of granulocyte differentiation (GO:0030853)2.40576076
110regulation of ARF protein signal transduction (GO:0032012)2.40413625
111T-helper 1 type immune response (GO:0042088)2.38566276
112positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.38015040
113positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.37895668
114T cell selection (GO:0045058)2.37310703
115positive regulation of Cdc42 GTPase activity (GO:0043089)2.35910511
116regulation of early endosome to late endosome transport (GO:2000641)2.35619504
117cellular response to nerve growth factor stimulus (GO:1990090)2.34670583
118response to nerve growth factor (GO:1990089)2.34670583
119positive regulation of gene expression, epigenetic (GO:0045815)2.29933773
120protein localization to kinetochore (GO:0034501)2.23970397
121establishment of endothelial barrier (GO:0061028)2.23888621
122Golgi to endosome transport (GO:0006895)2.22275258
123regulation of telomere maintenance via telomerase (GO:0032210)2.19972101
124cell fate commitment involved in formation of primary germ layer (GO:0060795)2.19561204
125chromatin assembly (GO:0031497)2.17787566
126negative regulation of telomerase activity (GO:0051974)2.15087634
127regulation of mammary gland epithelial cell proliferation (GO:0033599)2.13838247
128L-amino acid import (GO:0043092)2.09576817
129synaptic vesicle maturation (GO:0016188)2.08981379
130plasma membrane fusion (GO:0045026)2.08204055
131bone trabecula formation (GO:0060346)2.07164202
132mRNA stabilization (GO:0048255)2.05127110
133RNA stabilization (GO:0043489)2.05127110
134protein localization to chromosome, centromeric region (GO:0071459)2.04595932
135positive regulation of histone H3-K4 methylation (GO:0051571)2.04522626
136histone H3-K4 methylation (GO:0051568)2.04024012
137negative regulation of viral release from host cell (GO:1902187)2.03509078
138peptidyl-tyrosine autophosphorylation (GO:0038083)2.03251252
139negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.02924188
140response to laminar fluid shear stress (GO:0034616)2.02080967
141semaphorin-plexin signaling pathway (GO:0071526)2.02033818
142response to lipoprotein particle (GO:0055094)2.00795782
143interferon-gamma production (GO:0032609)1.98883902
144protein localization to endosome (GO:0036010)1.98493097
145astrocyte development (GO:0014002)1.97935940
146mitotic cytokinesis (GO:0000281)1.97445621
147ventricular system development (GO:0021591)1.96603024
148fusion of sperm to egg plasma membrane (GO:0007342)1.96534563
149stress fiber assembly (GO:0043149)1.95923318
150membrane raft organization (GO:0031579)1.95614655
151regulation of histone H3-K4 methylation (GO:0051569)1.95132112
152intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)1.94201669
153phosphatidylinositol 3-kinase signaling (GO:0014065)1.93741274
154pre-miRNA processing (GO:0031054)1.93098282
155centrosome duplication (GO:0051298)1.92897829
156membrane protein intracellular domain proteolysis (GO:0031293)1.92813479
157negative regulation of peptidyl-serine phosphorylation (GO:0033137)1.92504633
158branching involved in mammary gland duct morphogenesis (GO:0060444)1.92185483
159membrane tubulation (GO:0097320)1.91997283
160spindle assembly involved in mitosis (GO:0090307)1.90892311
161mRNA transcription from RNA polymerase II promoter (GO:0042789)1.90764244
162B cell receptor signaling pathway (GO:0050853)1.89722761
163negative regulation of cell killing (GO:0031342)1.88151262
164negative regulation of leukocyte mediated cytotoxicity (GO:0001911)1.88151262
165intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)1.86765875
166membrane protein ectodomain proteolysis (GO:0006509)1.86704557
167regulation of attachment of spindle microtubules to kinetochore (GO:0051988)1.86562454
168regulation of cilium movement (GO:0003352)1.85650352
169regulation of cytokine production involved in inflammatory response (GO:1900015)1.84927906
170negative regulation of phagocytosis (GO:0050765)1.82800450
171amino acid import (GO:0043090)1.82117593
172positive regulation of macrophage cytokine production (GO:0060907)1.81930433
173intracellular estrogen receptor signaling pathway (GO:0030520)1.79195470
174regulation of nuclear cell cycle DNA replication (GO:0033262)1.79140400
175chromatin silencing (GO:0006342)1.78694859
176negative regulation of axonogenesis (GO:0050771)1.77843121
177regulation of macrophage cytokine production (GO:0010935)1.77838352
178negative regulation of peptidyl-threonine phosphorylation (GO:0010801)1.76175882
179NLS-bearing protein import into nucleus (GO:0006607)1.76060901
180regulation of protein deacetylation (GO:0090311)1.75648708
181positive regulation of lipid kinase activity (GO:0090218)1.75584580
182activated T cell proliferation (GO:0050798)1.75439204
183regulation of interleukin-2 biosynthetic process (GO:0045076)1.75313117
184nuclear pore complex assembly (GO:0051292)1.75172590
185protein polyglutamylation (GO:0018095)1.74392277
186angiogenesis involved in wound healing (GO:0060055)1.73214979
187nucleosome disassembly (GO:0006337)1.72989748
188protein-DNA complex disassembly (GO:0032986)1.72989748
189regulation of mRNA stability (GO:0043488)1.71922071
190spindle assembly (GO:0051225)1.71571014
191regulation of histone deacetylation (GO:0031063)1.71423096

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.17817795
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.01967747
3SCL_19346495_ChIP-Seq_HPC-7_Human2.93152328
4NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.77906170
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.72116418
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.72116418
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.72116418
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.53625269
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.38373289
10* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.31887554
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.27485935
12MYC_22102868_ChIP-Seq_BL_Human2.25184697
13* TCF7_22412390_ChIP-Seq_EML_Mouse2.22481664
14* VDR_21846776_ChIP-Seq_THP-1_Human2.16340632
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15233504
16* KDM2B_26808549_Chip-Seq_DND41_Human2.14411332
17* SPI1_23127762_ChIP-Seq_K562_Human2.12666785
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07560055
19* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.07361886
20NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human2.05101648
21* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00711784
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00232762
23E2F7_22180533_ChIP-Seq_HELA_Human1.95835187
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94760350
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91441927
26* ELK3_25401928_ChIP-Seq_HUVEC_Human1.90969547
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89724834
28* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80271616
29* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.78984582
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.78934105
31ZFP281_27345836_Chip-Seq_ESCs_Mouse1.78570967
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.77921294
33* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.77110918
34* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.76538383
35TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.71608355
36MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.69423777
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67252166
38TP53_22127205_ChIP-Seq_IMR90_Human1.66962966
39* VDR_24763502_ChIP-Seq_THP-1_Human1.64783493
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.57164891
41* GATA1_19941827_ChIP-Seq_MEL_Mouse1.56771230
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.56639668
43* MAF_26560356_Chip-Seq_TH1_Human1.56433109
44* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53191066
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.51700676
46* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51201201
47GATA1_19941826_ChIP-Seq_K562_Human1.50842243
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.49814569
49* UTX_26944678_Chip-Seq_JUKART_Human1.49064460
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49055144
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.48352149
52* RARB_27405468_Chip-Seq_BRAIN_Mouse1.47979685
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45826002
54KDM2B_26808549_Chip-Seq_K562_Human1.43723107
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43416987
56* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40212397
57IRF8_27001747_Chip-Seq_BMDM_Mouse1.39705818
58* RUNX_20019798_ChIP-Seq_JUKART_Human1.39435902
59* KDM2B_26808549_Chip-Seq_JURKAT_Human1.39325253
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38127267
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34508984
62* MYB_26560356_Chip-Seq_TH2_Human1.34244931
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31854328
64* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27076136
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27015542
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.27011297
67* MYB_26560356_Chip-Seq_TH1_Human1.26132501
68* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25024207
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.24773017
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23753854
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23720307
72* NCOR1_26117541_ChIP-Seq_K562_Human1.23074960
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.21950402
74* VDR_24787735_ChIP-Seq_THP-1_Human1.20999924
75* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18437644
76P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16733773
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.16307564
78GATA1_22025678_ChIP-Seq_K562_Human1.15859892
79* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15056347
80STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14118432
81* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13812189
82CLOCK_20551151_ChIP-Seq_293T_Human1.13407536
83* SPI1_23547873_ChIP-Seq_NB4_Human1.13347357
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13085440
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12869416
86* SA1_27219007_Chip-Seq_ERYTHROID_Human1.11949078
87* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11881595
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10942042
89DROSHA_22980978_ChIP-Seq_HELA_Human1.10823578
90* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10172281
91MAF_26560356_Chip-Seq_TH2_Human1.09359200
92* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09336291
93* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09326633
94* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09302160
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07039585
96* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06612302
97PU_27001747_Chip-Seq_BMDM_Mouse1.06541007
98ESR2_21235772_ChIP-Seq_MCF-7_Human1.06300973
99* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05652768
100TP53_23651856_ChIP-Seq_MEFs_Mouse1.05094529
101TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04990442
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04186156
103MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03470922
104* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02050901
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00811670
106LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00445558
107NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00030141
108GATA2_19941826_ChIP-Seq_K562_Human0.99960581
109* LXR_22292898_ChIP-Seq_THP-1_Human0.98503809
110DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98466961
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98316354
112EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97692014
113* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97415961
114PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96993811
115P68_20966046_ChIP-Seq_HELA_Human0.96710520
116HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95850560
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94161173
118GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93364787
119ELF1_20517297_ChIP-Seq_JURKAT_Human0.93281038
120MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92726396
121* CREB1_26743006_Chip-Seq_LNCaP_Human0.92431621
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91317695
123E2F4_17652178_ChIP-ChIP_JURKAT_Human0.89644808
124SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.89576414
125SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88252294
126CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88099290
127ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86945422
128TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.85756859
129* WT1_19549856_ChIP-ChIP_CCG9911_Human0.84485300
130CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83389066
131FOXO3_23340844_ChIP-Seq_DLD1_Human0.83000611
132* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82816952
133TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82174125
134SMC4_20622854_ChIP-Seq_HELA_Human0.82094447
135* RACK7_27058665_Chip-Seq_MCF-7_Human0.81876426
136FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81439978
137NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79803855
138NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79341657
139CIITA_25753668_ChIP-Seq_RAJI_Human0.76445414
140ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.74307296

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.63485706
2MP0003724_increased_susceptibility_to2.58959044
3MP0003705_abnormal_hypodermis_morpholog2.58908723
4MP0005451_abnormal_body_composition2.54536573
5MP0002419_abnormal_innate_immunity2.49730281
6MP0005623_abnormal_meninges_morphology2.48098205
7MP0000920_abnormal_myelination2.25133359
8MP0005025_abnormal_response_to2.23560893
9MP0003950_abnormal_plasma_membrane2.19629152
10MP0005410_abnormal_fertilization2.16892235
11MP0003191_abnormal_cellular_cholesterol2.11847163
12MP0000733_abnormal_muscle_development2.11045495
13MP0004947_skin_inflammation1.98466013
14MP0009785_altered_susceptibility_to1.94768251
15MP0008438_abnormal_cutaneous_collagen1.92781425
16MP0008260_abnormal_autophagy1.90686116
17MP0002148_abnormal_hypersensitivity_rea1.90558052
18MP0001533_abnormal_skeleton_physiology1.82559250
19MP0003763_abnormal_thymus_physiology1.80231754
20MP0000569_abnormal_digit_pigmentation1.73881036
21MP0004859_abnormal_synaptic_plasticity1.72848352
22MP0003091_abnormal_cell_migration1.72808383
23MP0005464_abnormal_platelet_physiology1.71258540
24MP0002998_abnormal_bone_remodeling1.70717698
25MP0003828_pulmonary_edema1.70123355
26MP0002396_abnormal_hematopoietic_system1.67909852
27MP0001545_abnormal_hematopoietic_system1.65308527
28MP0005397_hematopoietic_system_phenotyp1.65308527
29MP0009840_abnormal_foam_cell1.62853682
30MP0000858_altered_metastatic_potential1.60446425
31MP0000604_amyloidosis1.55052638
32MP0003303_peritoneal_inflammation1.54754743
33MP0005076_abnormal_cell_differentiation1.50465428
34MP0010155_abnormal_intestine_physiology1.49622931
35MP0003045_fibrosis1.46624790
36MP0001348_abnormal_lacrimal_gland1.44708082
37MP0009278_abnormal_bone_marrow1.42052921
38MP0003075_altered_response_to1.41395264
39MP0003453_abnormal_keratinocyte_physiol1.37799275
40MP0003329_amyloid_beta_deposits1.35916113
41MP0009333_abnormal_splenocyte_physiolog1.34297263
42MP0004808_abnormal_hematopoietic_stem1.32689670
43MP0001845_abnormal_inflammatory_respons1.31705026
44MP0003656_abnormal_erythrocyte_physiolo1.28040231
45MP0001958_emphysema1.27848336
46MP0004270_analgesia1.27441378
47MP0003300_gastrointestinal_ulcer1.26720597
48MP0010352_gastrointestinal_tract_polyps1.26435144
49MP0001853_heart_inflammation1.26340207
50MP0000343_altered_response_to1.26168628
51MP0006082_CNS_inflammation1.25637422
52MP0003172_abnormal_lysosome_physiology1.23211197
53MP0008057_abnormal_DNA_replication1.19540869
54MP0003279_aneurysm1.17217826
55MP0004510_myositis1.14606927
56MP0005257_abnormal_intraocular_pressure1.12921133
57MP0003787_abnormal_imprinting1.10402761
58MP0008004_abnormal_stomach_pH1.09366736
59MP0009764_decreased_sensitivity_to1.08305796
60MP0005164_abnormal_response_to1.08031505
61MP0003448_altered_tumor_morphology1.07442819
62MP0005075_abnormal_melanosome_morpholog1.04138541
63MP0008469_abnormal_protein_level1.03432321
64MP0002925_abnormal_cardiovascular_devel1.03139068
65MP0003566_abnormal_cell_adhesion1.02504942
66MP0005166_decreased_susceptibility_to1.01251626
67MP0006292_abnormal_olfactory_placode1.01171219
68MP0002398_abnormal_bone_marrow1.01100086
69MP0005310_abnormal_salivary_gland1.00413909
70MP0003634_abnormal_glial_cell1.00118416
71MP0005000_abnormal_immune_tolerance0.98761038
72MP0000750_abnormal_muscle_regeneration0.98522026
73MP0004883_abnormal_blood_vessel0.98074433
74MP0000749_muscle_degeneration0.97819723
75MP0002420_abnormal_adaptive_immunity0.97498218
76MP0000703_abnormal_thymus_morphology0.97301455
77MP0002877_abnormal_melanocyte_morpholog0.97030343
78MP0005390_skeleton_phenotype0.97001631
79MP0002933_joint_inflammation0.96812083
80MP0002452_abnormal_antigen_presenting0.96160552
81MP0003938_abnormal_ear_development0.95716030
82MP0001819_abnormal_immune_cell0.95565457
83MP0004858_abnormal_nervous_system0.95413059
84MP0003121_genomic_imprinting0.95400949
85MP0008961_abnormal_basal_metabolism0.94885655
86MP0001790_abnormal_immune_system0.94099031
87MP0005387_immune_system_phenotype0.94099031
88MP0000759_abnormal_skeletal_muscle0.94074862
89MP0000685_abnormal_immune_system0.92385379
90MP0001800_abnormal_humoral_immune0.90782901
91MP0002092_abnormal_eye_morphology0.89274146
92MP0004185_abnormal_adipocyte_glucose0.89116267
93MP0000428_abnormal_craniofacial_morphol0.87923074
94MP0000716_abnormal_immune_system0.87807271
95MP0005171_absent_coat_pigmentation0.86585413
96MP0004145_abnormal_muscle_electrophysio0.85207065
97MP0002723_abnormal_immune_serum0.85085185
98MP0008007_abnormal_cellular_replicative0.85019458
99MP0001293_anophthalmia0.84977757
100MP0005666_abnormal_adipose_tissue0.84182782
101MP0005409_darkened_coat_color0.83818042
102MP0008770_decreased_survivor_rate0.82697306
103MP0005394_taste/olfaction_phenotype0.82563190
104MP0005499_abnormal_olfactory_system0.82563190
105MP0000465_gastrointestinal_hemorrhage0.82536305
106MP0003632_abnormal_nervous_system0.82416680
107MP0001851_eye_inflammation0.81238179
108MP0001849_ear_inflammation0.80743120
109MP0008874_decreased_physiological_sensi0.80717874
110MP0000350_abnormal_cell_proliferation0.80602553
111MP0003795_abnormal_bone_structure0.79568856
112MP0005671_abnormal_response_to0.79198937
113MP0008569_lethality_at_weaning0.79033939
114MP0001835_abnormal_antigen_presentation0.77811320
115MP0003866_abnormal_defecation0.77777132
116MP0000249_abnormal_blood_vessel0.77717517
117MP0005174_abnormal_tail_pigmentation0.77563788
118MP0005023_abnormal_wound_healing0.77266572
119MP0005621_abnormal_cell_physiology0.76869079
120MP0002405_respiratory_system_inflammati0.76746539
121MP0002722_abnormal_immune_system0.76654936
122MP0003183_abnormal_peptide_metabolism0.76498584
123MP0003890_abnormal_embryonic-extraembry0.76346537
124MP0000689_abnormal_spleen_morphology0.75949299
125MP0002114_abnormal_axial_skeleton0.75704516
126MP0000313_abnormal_cell_death0.75616778
127MP0000383_abnormal_hair_follicle0.75548421
128MP0000767_abnormal_smooth_muscle0.75235170
129MP0003984_embryonic_growth_retardation0.75196752
130MP0000955_abnormal_spinal_cord0.75194813
131MP0003283_abnormal_digestive_organ0.74362268
132MP0003690_abnormal_glial_cell0.74285960
133MP0005380_embryogenesis_phenotype0.73935547
134MP0001672_abnormal_embryogenesis/_devel0.73935547
135MP0003935_abnormal_craniofacial_develop0.73825462
136MP0001915_intracranial_hemorrhage0.73805141
137MP0005058_abnormal_lysosome_morphology0.73589882
138MP0000747_muscle_weakness0.73567304
139MP0002429_abnormal_blood_cell0.73465083
140MP0000778_abnormal_nervous_system0.73369529
141MP0002088_abnormal_embryonic_growth/wei0.72851845
142MP0004742_abnormal_vestibular_system0.72671528
143MP0002085_abnormal_embryonic_tissue0.72503429
144MP0001542_abnormal_bone_strength0.72484313
145MP0004087_abnormal_muscle_fiber0.72125918
146MP0004264_abnormal_extraembryonic_tissu0.72073079
147MP0010678_abnormal_skin_adnexa0.71537274
148MP0002932_abnormal_joint_morphology0.71136876
149MP0005375_adipose_tissue_phenotype0.67356272
150MP0001663_abnormal_digestive_system0.64378759

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.15144244
2Recurrent abscess formation (HP:0002722)3.65794541
3Recurrent bacterial skin infections (HP:0005406)3.64535957
4Abnormality of macrophages (HP:0004311)3.51710738
5Myositis (HP:0100614)3.00015108
6Interstitial pulmonary disease (HP:0006530)2.83336859
7Orchitis (HP:0100796)2.80700686
8Spontaneous hematomas (HP:0007420)2.79286013
9Mediastinal lymphadenopathy (HP:0100721)2.75009465
10Gingivitis (HP:0000230)2.66037265
11Increased cerebral lipofuscin (HP:0011813)2.59503293
12Recurrent gram-negative bacterial infections (HP:0005420)2.58158670
13Premature rupture of membranes (HP:0001788)2.56970961
14Dysostosis multiplex (HP:0000943)2.55736171
15Recurrent fungal infections (HP:0002841)2.51639794
16Colitis (HP:0002583)2.51058654
17Difficulty running (HP:0009046)2.46535587
18Obstructive lung disease (HP:0006536)2.42839338
19Chronic obstructive pulmonary disease (HP:0006510)2.42839338
20Increased IgE level (HP:0003212)2.41962334
21Recurrent viral infections (HP:0004429)2.40403754
22Retrobulbar optic neuritis (HP:0100654)2.37659388
23Optic neuritis (HP:0100653)2.37659388
24Sensory axonal neuropathy (HP:0003390)2.36533826
25Absent frontal sinuses (HP:0002688)2.35287778
26Recurrent skin infections (HP:0001581)2.34486247
27Supranuclear gaze palsy (HP:0000605)2.34422779
28Meningitis (HP:0001287)2.33428109
29Gastrointestinal infarctions (HP:0005244)2.27137088
30Distal lower limb amyotrophy (HP:0008944)2.26828443
31Distal upper limb amyotrophy (HP:0007149)2.23706409
32Upper limb amyotrophy (HP:0009129)2.23706409
33Abnormality of the fingertips (HP:0001211)2.23346051
34Fused cervical vertebrae (HP:0002949)2.22990877
35Akinesia (HP:0002304)2.21785160
36Gastrointestinal inflammation (HP:0004386)2.19897923
37Vertebral compression fractures (HP:0002953)2.18714410
38Obstructive sleep apnea (HP:0002870)2.18486930
39Rib fusion (HP:0000902)2.15359798
40Recurrent cutaneous fungal infections (HP:0011370)2.14739894
41Chronic mucocutaneous candidiasis (HP:0002728)2.14739894
42Degeneration of the lateral corticospinal tracts (HP:0002314)2.14437691
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.14437691
44Inflammation of the large intestine (HP:0002037)2.13718657
45Large earlobe (HP:0009748)2.13203508
46Polycythemia (HP:0001901)2.12007408
47Neurofibrillary tangles (HP:0002185)2.10138281
48Abnormal auditory evoked potentials (HP:0006958)2.09212526
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.08982368
50Thin bony cortex (HP:0002753)2.08371148
51Slow saccadic eye movements (HP:0000514)2.08317515
52Nasal polyposis (HP:0100582)2.06701386
53Dilatation of the ascending aorta (HP:0005111)2.05580942
54Abnormality of the corticospinal tract (HP:0002492)2.04108313
55Cerebral aneurysm (HP:0004944)2.03992987
56Shallow orbits (HP:0000586)2.03617238
57Vasculitis (HP:0002633)2.03541106
58Gastrointestinal stroma tumor (HP:0100723)2.03201229
59Amyloidosis (HP:0011034)2.02772147
60Lower limb amyotrophy (HP:0007210)2.02553606
61Increased neuronal autofluorescent lipopigment (HP:0002074)2.01908566
62Spondylolisthesis (HP:0003302)2.01539008
63Bilateral microphthalmos (HP:0007633)2.01378032
64Abnormality of glycolipid metabolism (HP:0010969)2.01144077
65Abnormality of liposaccharide metabolism (HP:0010968)2.01144077
66Abnormality of glycosphingolipid metabolism (HP:0004343)2.01144077
67Segmental peripheral demyelination/remyelination (HP:0003481)1.98872296
68Ulnar bowing (HP:0003031)1.98756742
69Hyperacusis (HP:0010780)1.96797882
70Apathy (HP:0000741)1.96677945
71Abnormality of the nasal mucosa (HP:0000433)1.95610087
72Emphysema (HP:0002097)1.95153035
73Mildly elevated creatine phosphokinase (HP:0008180)1.94790563
74Urticaria (HP:0001025)1.94063774
75Stomatitis (HP:0010280)1.93650121
76Abnormality of polysaccharide metabolism (HP:0011012)1.93137868
77Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93137868
78Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93137868
79Round ear (HP:0100830)1.91931394
80Ependymoma (HP:0002888)1.91780499
81Urinary glycosaminoglycan excretion (HP:0003541)1.91768385
82Mucopolysacchariduria (HP:0008155)1.91768385
83Prolonged bleeding time (HP:0003010)1.89340605
84Broad face (HP:0000283)1.88952346
85Myocardial infarction (HP:0001658)1.88897129
86Abnormality of the lower motor neuron (HP:0002366)1.88566760
87Osteomyelitis (HP:0002754)1.87451384
88Systemic lupus erythematosus (HP:0002725)1.87147485
89Cellulitis (HP:0100658)1.85277391
90Protrusio acetabuli (HP:0003179)1.84492017
91Aneurysm (HP:0002617)1.84040179
92Epistaxis (HP:0000421)1.82974398
93Scapular winging (HP:0003691)1.82961159
94Viral hepatitis (HP:0006562)1.82847190
95Onion bulb formation (HP:0003383)1.82757599
96Abnormality of skeletal muscle fiber size (HP:0012084)1.81952100
97Keratoconjunctivitis sicca (HP:0001097)1.80720225
98Pulmonary infiltrates (HP:0002113)1.79850239
99Increased variability in muscle fiber diameter (HP:0003557)1.79201942
100Diminished motivation (HP:0000745)1.78812291
101Hemoptysis (HP:0002105)1.78725173
102Abnormality of the astrocytes (HP:0100707)1.77916182
103Astrocytoma (HP:0009592)1.77916182
104Thoracic kyphosis (HP:0002942)1.77016963
105Upper motor neuron abnormality (HP:0002127)1.76578961
106Restrictive lung disease (HP:0002091)1.76253171
107Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.75974432
108Autoimmune thrombocytopenia (HP:0001973)1.75913183
109Trismus (HP:0000211)1.75704754
110Cerebral inclusion bodies (HP:0100314)1.75623307
111Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.75130726
112Abnormality of the peritoneum (HP:0002585)1.74930824
113Agammaglobulinemia (HP:0004432)1.74905075
114Overriding aorta (HP:0002623)1.73934723
115Polygenic inheritance (HP:0010982)1.73654591
116Fetal akinesia sequence (HP:0001989)1.73562910
117Centrally nucleated skeletal muscle fibers (HP:0003687)1.72408091
118Peritonitis (HP:0002586)1.71164722
119Chronic otitis media (HP:0000389)1.70773964
120Abnormality of the thoracic spine (HP:0100711)1.70485413
121Pustule (HP:0200039)1.70215632
122Nuclear cataract (HP:0100018)1.69399103
123Increased density of long bones (HP:0006392)1.69373523
124Premature skin wrinkling (HP:0100678)1.69237392
125Macroorchidism (HP:0000053)1.69108541
126Gowers sign (HP:0003391)1.68219333
127Fatigue (HP:0012378)1.67304639
128Prominent occiput (HP:0000269)1.67157563
129Weak cry (HP:0001612)1.66272693
130Axonal loss (HP:0003447)1.65321649
131Arterial thrombosis (HP:0004420)1.65181941
132Pointed chin (HP:0000307)1.64805605
133Slender build (HP:0001533)1.64235429
134Renal duplication (HP:0000075)1.63521752
135Dislocated radial head (HP:0003083)1.63382437
136Bladder diverticulum (HP:0000015)1.62126283
137Buphthalmos (HP:0000557)1.61013571
138Increased connective tissue (HP:0009025)1.59357065
139Neoplasm of the heart (HP:0100544)1.59198335
140Mitral regurgitation (HP:0001653)1.56364113
141Neuronal loss in central nervous system (HP:0002529)1.53775229
142Disproportionate tall stature (HP:0001519)1.53484603
143Vertebral fusion (HP:0002948)1.53311519
144Generalized hypotonia (HP:0001290)1.53257678
145Flat cornea (HP:0007720)1.52039775
146Partial duplication of thumb phalanx (HP:0009944)1.51923510
147Ankle contracture (HP:0006466)1.51856304
148Broad metatarsal (HP:0001783)1.51427418
149Supernumerary ribs (HP:0005815)1.50359287
150Amyotrophic lateral sclerosis (HP:0007354)1.48655120
151Peripheral hypomyelination (HP:0007182)1.48489350
152Rapidly progressive (HP:0003678)1.48036736
153Easy fatigability (HP:0003388)1.47979216
154Abnormality of the radial head (HP:0003995)1.47924376
155Difficulty climbing stairs (HP:0003551)1.47309792
156Spastic gait (HP:0002064)1.45325880
157Syringomyelia (HP:0003396)1.44812044
158Spinal cord lesions (HP:0100561)1.44812044
159Elevated erythrocyte sedimentation rate (HP:0003565)1.44020029
160Muscle fiber atrophy (HP:0100295)1.42554487
161Open mouth (HP:0000194)1.42535806
162Partial duplication of the phalanx of hand (HP:0009999)1.41133489
163Increased nuchal translucency (HP:0010880)1.40565189
164Ocular albinism (HP:0001107)1.39669524
165Type 2 muscle fiber atrophy (HP:0003554)1.39298098
166Mitral valve prolapse (HP:0001634)1.39297357
167Chest pain (HP:0100749)1.38617672
168Loss of speech (HP:0002371)1.38406186
169Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.38309747
170Genu recurvatum (HP:0002816)1.38228630
171Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.37300294
172Absent/shortened dynein arms (HP:0200106)1.37274944
173Dynein arm defect of respiratory motile cilia (HP:0012255)1.37274944
174Osteolytic defects of the hand bones (HP:0009699)1.37217659

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.40612563
2EPHB13.53948034
3TYRO32.62685581
4CSF1R2.40608976
5EEF2K2.36627996
6IRAK32.33679799
7ICK2.29752311
8MAP2K32.21448984
9CLK12.14419709
10WNK12.12024001
11MOS2.07776429
12STK101.93224307
13TYK21.92851474
14MAP3K141.91971439
15STK391.87313196
16TGFBR21.84306702
17GRK61.79907495
18SMG11.74844517
19FES1.73400468
20TESK21.69926592
21ALK1.67571233
22ZAP701.62773232
23TAOK21.55596354
24TBK11.48813422
25TTN1.46521358
26MAP3K101.46105639
27MAP4K11.45348613
28MAP3K31.43137151
29SIK11.41642872
30KSR21.40898961
31SIK21.39815271
32PRKD31.38181740
33JAK31.37523983
34PRPF4B1.36204892
35MAPK71.36184034
36CDC42BPA1.31210139
37CDK191.30908087
38NTRK11.29118225
39DMPK1.27972436
40MAP3K111.27710190
41GRK51.25855464
42CSK1.23424788
43ERN11.23352241
44HIPK21.21921539
45BTK1.18628413
46TRIB31.18222527
47MAP3K11.17390649
48TTK1.16328017
49PAK61.14608222
50MATK1.14226118
51FGFR41.13431554
52RIPK41.10952228
53HCK1.09933198
54TRPM71.09629836
55KIT1.09605856
56JAK11.08484191
57ROCK21.05746318
58CAMK1G1.04526461
59EPHA41.04116241
60PDGFRB1.01028928
61IKBKE1.01024214
62TNIK1.00652783
63SIK30.99587266
64SYK0.97809241
65MAPKAPK50.96615293
66UHMK10.95485565
67BRD40.94488628
68OXSR10.93420924
69PRKD20.92784858
70JAK20.91781706
71ITK0.91556013
72PKN10.91498886
73BMX0.89748430
74MAP3K130.88807293
75FGR0.88701161
76TNK20.87975774
77PTK2B0.87805469
78PAK20.85685843
79MTOR0.85151842
80CDK150.84615047
81IRAK40.84547122
82* MARK20.83725145
83DDR20.83282627
84NME20.82783001
85BLK0.82400099
86TESK10.81284671
87CDK11A0.81164985
88MAP3K60.81013436
89IKBKB0.80284962
90LRRK20.79175637
91MAPK120.77846952
92CDK60.76698473
93PRKD10.74784680
94CDK180.73852809
95PNCK0.72785075
96CDK140.72436995
97PDGFRA0.72306255
98LYN0.70155238
99CAMK40.70081270
100RIPK10.69853835
101RPS6KA20.67891132
102RPS6KC10.67304342
103RPS6KL10.67304342
104MAP3K70.66755219
105SGK30.64813548
106CAMK1D0.64255557
107LCK0.62118914
108FYN0.61742057
109PRKCH0.61680271
110CAMKK10.61676685
111BMPR20.61074711
112MAP3K80.59370080
113CDK40.58431208
114PDK10.58258392
115FGFR30.55713703
116NEK90.54959994
117MARK30.53512231
118PTK20.52754916
119MAPK110.52668887
120MAPK100.52275159
121STK380.52254108
122PRKG20.52084116
123RET0.50238239
124PKN20.49830960
125* PAK10.49117739
126YES10.48731345
127INSR0.48581591
128NEK20.48216346
129ADRBK20.47900694
130PRKCQ0.47829984
131RPS6KA60.47650471
132GRK10.46694803
133FGFR20.46165887
134CDK50.45988015
135PTK60.45585378
136PDPK10.44923115
137ILK0.44019368
138MAPK40.43941224
139IRAK20.43271958
140IRAK10.43183323
141TAOK10.41514961
142CHUK0.40564834
143LATS20.40489885
144SRC0.39074255
145DYRK1B0.37213084
146* CHEK10.37037123
147GRK70.36870390
148NEK60.36478053
149MET0.36019540

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.99742609
2Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.84997210
3B cell receptor signaling pathway_Homo sapiens_hsa046621.56496067
4Staphylococcus aureus infection_Homo sapiens_hsa051501.53686960
5Allograft rejection_Homo sapiens_hsa053301.41208912
6Influenza A_Homo sapiens_hsa051641.39712911
7Graft-versus-host disease_Homo sapiens_hsa053321.32697770
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.31760449
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29065799
10Regulation of actin cytoskeleton_Homo sapiens_hsa048101.28212174
11Leukocyte transendothelial migration_Homo sapiens_hsa046701.24367540
12T cell receptor signaling pathway_Homo sapiens_hsa046601.22761707
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22717572
14Chronic myeloid leukemia_Homo sapiens_hsa052201.22516497
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22501485
16Phospholipase D signaling pathway_Homo sapiens_hsa040721.20633025
17Autoimmune thyroid disease_Homo sapiens_hsa053201.20485451
18Lysosome_Homo sapiens_hsa041421.20463345
19Shigellosis_Homo sapiens_hsa051311.19913216
20Renal cell carcinoma_Homo sapiens_hsa052111.15787667
21Axon guidance_Homo sapiens_hsa043601.15778621
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15004613
23Osteoclast differentiation_Homo sapiens_hsa043801.14025366
24Pertussis_Homo sapiens_hsa051331.13073798
25VEGF signaling pathway_Homo sapiens_hsa043701.12444630
26Bladder cancer_Homo sapiens_hsa052191.11319178
27Platelet activation_Homo sapiens_hsa046111.09248314
28Hepatitis C_Homo sapiens_hsa051601.06551208
29Notch signaling pathway_Homo sapiens_hsa043301.06204603
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04556709
31Phagosome_Homo sapiens_hsa041451.04425833
32Endocytosis_Homo sapiens_hsa041441.04099442
33Prion diseases_Homo sapiens_hsa050201.03793063
34Leishmaniasis_Homo sapiens_hsa051401.03706620
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03291267
36Focal adhesion_Homo sapiens_hsa045101.02945182
37Pancreatic cancer_Homo sapiens_hsa052121.02760124
38Herpes simplex infection_Homo sapiens_hsa051681.01661961
39Sphingolipid signaling pathway_Homo sapiens_hsa040711.00497819
40Amoebiasis_Homo sapiens_hsa051461.00470140
41Acute myeloid leukemia_Homo sapiens_hsa052210.99785342
42Neurotrophin signaling pathway_Homo sapiens_hsa047220.99671951
43Chemokine signaling pathway_Homo sapiens_hsa040620.99365835
44MicroRNAs in cancer_Homo sapiens_hsa052060.99286572
45Prolactin signaling pathway_Homo sapiens_hsa049170.97847613
46Salmonella infection_Homo sapiens_hsa051320.97136316
47Legionellosis_Homo sapiens_hsa051340.96611553
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.96571731
49Proteoglycans in cancer_Homo sapiens_hsa052050.96392171
50African trypanosomiasis_Homo sapiens_hsa051430.96167486
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95445459
52Rap1 signaling pathway_Homo sapiens_hsa040150.94222454
53Endometrial cancer_Homo sapiens_hsa052130.93304458
54Rheumatoid arthritis_Homo sapiens_hsa053230.93000295
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92407355
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91707052
57MAPK signaling pathway_Homo sapiens_hsa040100.91386474
58Glutamatergic synapse_Homo sapiens_hsa047240.90623135
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.90358783
60Dilated cardiomyopathy_Homo sapiens_hsa054140.90042601
61Asthma_Homo sapiens_hsa053100.89671890
62Glioma_Homo sapiens_hsa052140.88531868
63Ether lipid metabolism_Homo sapiens_hsa005650.87689175
64Non-small cell lung cancer_Homo sapiens_hsa052230.87158788
65Long-term potentiation_Homo sapiens_hsa047200.86072493
66Choline metabolism in cancer_Homo sapiens_hsa052310.86056489
67Primary immunodeficiency_Homo sapiens_hsa053400.85095049
68Inositol phosphate metabolism_Homo sapiens_hsa005620.84521501
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84174052
70Oxytocin signaling pathway_Homo sapiens_hsa049210.83804966
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83646250
72Toxoplasmosis_Homo sapiens_hsa051450.83009760
73ECM-receptor interaction_Homo sapiens_hsa045120.82722151
74Type I diabetes mellitus_Homo sapiens_hsa049400.82507451
75mTOR signaling pathway_Homo sapiens_hsa041500.82284092
76Long-term depression_Homo sapiens_hsa047300.82114011
77Ras signaling pathway_Homo sapiens_hsa040140.80851793
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80154039
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80060390
80Apoptosis_Homo sapiens_hsa042100.79515662
81Viral myocarditis_Homo sapiens_hsa054160.79476807
82ErbB signaling pathway_Homo sapiens_hsa040120.79260428
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79251147
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79238676
85Colorectal cancer_Homo sapiens_hsa052100.79189008
86mRNA surveillance pathway_Homo sapiens_hsa030150.78257021
87Malaria_Homo sapiens_hsa051440.77501813
88Other glycan degradation_Homo sapiens_hsa005110.76622525
89Small cell lung cancer_Homo sapiens_hsa052220.76602873
90HIF-1 signaling pathway_Homo sapiens_hsa040660.76583590
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76061522
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.75392081
93Pathways in cancer_Homo sapiens_hsa052000.73371065
94GnRH signaling pathway_Homo sapiens_hsa049120.72439433
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.72212670
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71599232
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71461543
98Dorso-ventral axis formation_Homo sapiens_hsa043200.71186026
99Tight junction_Homo sapiens_hsa045300.71143028
100Measles_Homo sapiens_hsa051620.69840642
101Cholinergic synapse_Homo sapiens_hsa047250.69835332
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.68614605
103TNF signaling pathway_Homo sapiens_hsa046680.68597748
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68532112
105Prostate cancer_Homo sapiens_hsa052150.67999771
106Viral carcinogenesis_Homo sapiens_hsa052030.67677756
107HTLV-I infection_Homo sapiens_hsa051660.67334744
108Tuberculosis_Homo sapiens_hsa051520.67115974
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67023164
110Circadian entrainment_Homo sapiens_hsa047130.65881427
111FoxO signaling pathway_Homo sapiens_hsa040680.64661771
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64032552
113Hepatitis B_Homo sapiens_hsa051610.63908724
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.63885183
115Estrogen signaling pathway_Homo sapiens_hsa049150.62908769
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62773766
117Morphine addiction_Homo sapiens_hsa050320.62737556
118Adherens junction_Homo sapiens_hsa045200.62050769
119Salivary secretion_Homo sapiens_hsa049700.62034192
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61885567
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61842200
122Epstein-Barr virus infection_Homo sapiens_hsa051690.60859057
123Type II diabetes mellitus_Homo sapiens_hsa049300.60585478
124Gap junction_Homo sapiens_hsa045400.60357385
125Insulin signaling pathway_Homo sapiens_hsa049100.59250939
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58983242
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57698936
128Hematopoietic cell lineage_Homo sapiens_hsa046400.57065411
129Renin secretion_Homo sapiens_hsa049240.56367264
130Wnt signaling pathway_Homo sapiens_hsa043100.55941808
131Gastric acid secretion_Homo sapiens_hsa049710.55614736
132cAMP signaling pathway_Homo sapiens_hsa040240.55437149
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.55137548
134Antigen processing and presentation_Homo sapiens_hsa046120.55086188

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