ARHGEF25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.70131517
2locomotory exploration behavior (GO:0035641)5.55252378
3synaptic vesicle maturation (GO:0016188)5.52210832
4synaptic vesicle docking involved in exocytosis (GO:0016081)5.24423500
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.08497894
6glutamate secretion (GO:0014047)4.96189090
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.93765230
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.78098433
9vocalization behavior (GO:0071625)4.77431731
10synaptic vesicle exocytosis (GO:0016079)4.65755020
11regulation of glutamate receptor signaling pathway (GO:1900449)4.50105768
12regulation of neuronal synaptic plasticity (GO:0048168)4.43033578
13cerebellar granule cell differentiation (GO:0021707)4.35099732
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.30951649
15exploration behavior (GO:0035640)4.27875995
16protein localization to synapse (GO:0035418)4.19532592
17regulation of synapse structural plasticity (GO:0051823)4.12700152
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.10508804
19regulation of synaptic vesicle exocytosis (GO:2000300)4.09338775
20positive regulation of synapse maturation (GO:0090129)4.09103827
21dendritic spine morphogenesis (GO:0060997)4.08095318
22layer formation in cerebral cortex (GO:0021819)4.03995674
23neuronal action potential propagation (GO:0019227)3.96310281
24establishment of nucleus localization (GO:0040023)3.90073044
25synaptic transmission, glutamatergic (GO:0035249)3.84228210
26L-amino acid import (GO:0043092)3.81864866
27postsynaptic membrane organization (GO:0001941)3.77493824
28positive regulation of fibroblast migration (GO:0010763)3.70879137
29regulation of synaptic vesicle transport (GO:1902803)3.69565557
30amino acid import (GO:0043090)3.68204641
31sodium ion export (GO:0071436)3.65300295
32axonal fasciculation (GO:0007413)3.64967725
33glutamate receptor signaling pathway (GO:0007215)3.64338679
34potassium ion homeostasis (GO:0055075)3.63677941
35cell communication by electrical coupling (GO:0010644)3.59249420
36axon ensheathment in central nervous system (GO:0032291)3.57518128
37central nervous system myelination (GO:0022010)3.57518128
38long-term memory (GO:0007616)3.57500104
39neurotransmitter secretion (GO:0007269)3.55848110
40regulation of synaptic plasticity (GO:0048167)3.54511647
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.52946581
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.51372566
43innervation (GO:0060384)3.50519662
44regulation of dendritic spine morphogenesis (GO:0061001)3.49981874
45dendritic spine organization (GO:0097061)3.49807045
46regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.48489329
47proline transport (GO:0015824)3.46810040
48neuron recognition (GO:0008038)3.46368466
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.44725603
50regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.44709396
51potassium ion import (GO:0010107)3.43807561
52cellular potassium ion homeostasis (GO:0030007)3.42877284
53neuromuscular process controlling balance (GO:0050885)3.38441649
54neuron-neuron synaptic transmission (GO:0007270)3.32585819
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30803447
56regulation of postsynaptic membrane potential (GO:0060078)3.26640497
57activation of protein kinase A activity (GO:0034199)3.25676838
58negative regulation of dendrite morphogenesis (GO:0050774)3.25351115
59positive regulation of membrane potential (GO:0045838)3.20784925
60positive regulation of dendritic spine morphogenesis (GO:0061003)3.19639213
61regulation of voltage-gated calcium channel activity (GO:1901385)3.17743546
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.15659107
63neuron projection extension involved in neuron projection guidance (GO:1902284)3.14641136
64axon extension involved in axon guidance (GO:0048846)3.14641136
65neurotransmitter-gated ion channel clustering (GO:0072578)3.11085514
66G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.09155447
67dendrite morphogenesis (GO:0048813)3.07967779
68neuron cell-cell adhesion (GO:0007158)3.06632677
69synaptic vesicle endocytosis (GO:0048488)3.06143905
70positive regulation of dendritic spine development (GO:0060999)3.00720510
71regulation of synapse maturation (GO:0090128)2.99759236
72regulation of neurotransmitter levels (GO:0001505)2.99303089
73long-term synaptic potentiation (GO:0060291)2.99157957
74cell migration in hindbrain (GO:0021535)2.98009093
75neuronal ion channel clustering (GO:0045161)2.97458291
76cytoskeletal anchoring at plasma membrane (GO:0007016)2.97164544
77regulation of vesicle fusion (GO:0031338)2.91269604
78regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90342422
79regulation of neurotransmitter secretion (GO:0046928)2.89209451
80plasma membrane repair (GO:0001778)2.88716288
81behavioral fear response (GO:0001662)2.88229811
82behavioral defense response (GO:0002209)2.88229811
83positive regulation of neurotransmitter transport (GO:0051590)2.86931197
84regulation of dendritic spine development (GO:0060998)2.84450089
85cellular sodium ion homeostasis (GO:0006883)2.82882288
86regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.81932915
87cerebellar Purkinje cell differentiation (GO:0021702)2.81437722
88membrane depolarization during action potential (GO:0086010)2.80641701
89membrane depolarization (GO:0051899)2.79841317
90cell communication involved in cardiac conduction (GO:0086065)2.79521091
91auditory behavior (GO:0031223)2.79240214
92negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.76360542
93positive regulation of neurotransmitter secretion (GO:0001956)2.75750467
94regulation of ARF protein signal transduction (GO:0032012)2.75370970
95long term synaptic depression (GO:0060292)2.73497722
96positive regulation of dendrite morphogenesis (GO:0050775)2.73441263
97mating behavior (GO:0007617)2.73065066
98chemosensory behavior (GO:0007635)2.72835552
99positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.72552378
100neuromuscular process (GO:0050905)2.71545278
101ephrin receptor signaling pathway (GO:0048013)2.71101652
102transmission of nerve impulse (GO:0019226)2.70835724
103neurotransmitter transport (GO:0006836)2.70508065
104gamma-aminobutyric acid signaling pathway (GO:0007214)2.70356637
105positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.69866838
106regulation of synaptic transmission (GO:0050804)2.69620212
107cerebellar Purkinje cell layer development (GO:0021680)2.68858240
108positive regulation of dendrite development (GO:1900006)2.68771138
109signal complex assembly (GO:0007172)2.67946844
110fear response (GO:0042596)2.66764641
111regulation of axon extension involved in axon guidance (GO:0048841)2.66117970
112vesicle transport along microtubule (GO:0047496)2.64631567
113negative regulation of catenin import into nucleus (GO:0035414)2.64333037
114central nervous system projection neuron axonogenesis (GO:0021952)2.63639399
115neuromuscular process controlling posture (GO:0050884)2.63324681
116learning (GO:0007612)2.60587247
117regulation of dendrite morphogenesis (GO:0048814)2.60569416
118gamma-aminobutyric acid transport (GO:0015812)2.60566176
119regulation of neurotransmitter transport (GO:0051588)2.59990832
120inner ear receptor cell development (GO:0060119)2.59556274
121regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.57745045
122peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.56834083
123myelination in peripheral nervous system (GO:0022011)2.54299944
124peripheral nervous system axon ensheathment (GO:0032292)2.54299944
125cell differentiation in hindbrain (GO:0021533)2.53973771
126neuromuscular synaptic transmission (GO:0007274)2.52349077
127protein retention in ER lumen (GO:0006621)2.52342423
128astrocyte development (GO:0014002)2.47594432
129acidic amino acid transport (GO:0015800)2.46532117
130protein targeting to plasma membrane (GO:0072661)2.40950668

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.94041875
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.20537949
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.13440347
4EZH2_18974828_ChIP-Seq_MESCs_Mouse3.09766998
5RNF2_18974828_ChIP-Seq_MESCs_Mouse3.09766998
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08969107
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.88858827
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.75816086
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.72414720
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.64378848
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.62750780
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.59881598
13GBX2_23144817_ChIP-Seq_PC3_Human2.58866839
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56044750
15DROSHA_22980978_ChIP-Seq_HELA_Human2.52665396
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.52405218
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41267743
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.39143723
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.38944053
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.28883223
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.27794115
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22992121
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.16361258
24REST_21632747_ChIP-Seq_MESCs_Mouse2.14841153
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.10211548
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.96928325
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.94150961
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86651874
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.86119754
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.83708875
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.83497547
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.68337504
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64362199
34RING1B_27294783_Chip-Seq_ESCs_Mouse1.59060341
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58201802
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.55112060
37KDM2B_26808549_Chip-Seq_K562_Human1.54439609
38RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.53985843
39ZFP281_27345836_Chip-Seq_ESCs_Mouse1.48086503
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47933816
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47456363
42TP53_20018659_ChIP-ChIP_R1E_Mouse1.42645235
43EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42581384
44RING1B_27294783_Chip-Seq_NPCs_Mouse1.41676814
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40729237
46AR_21572438_ChIP-Seq_LNCaP_Human1.40161316
47WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38860729
48ZNF274_21170338_ChIP-Seq_K562_Hela1.38356827
49TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37045565
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33690063
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33202193
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.29735545
53UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27931942
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26815594
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24158636
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24086416
57SMAD4_21799915_ChIP-Seq_A2780_Human1.22245080
58AR_19668381_ChIP-Seq_PC3_Human1.21891386
59EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21704651
60TP53_16413492_ChIP-PET_HCT116_Human1.21284083
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20405591
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20177272
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19986448
64SMC4_20622854_ChIP-Seq_HELA_Human1.19720193
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18686982
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17757491
67CREB1_26743006_Chip-Seq_LNCaP_Human1.16255917
68RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15079838
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.10794313
70EP300_21415370_ChIP-Seq_HL-1_Mouse1.10466862
71* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09735941
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08988120
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08852691
74RACK7_27058665_Chip-Seq_MCF-7_Human1.06891622
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06769423
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06352445
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06268957
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02985109
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02731164
80CLOCK_20551151_ChIP-Seq_293T_Human1.02298776
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.02081505
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01365061
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00601402
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00017465
85SMAD_19615063_ChIP-ChIP_OVARY_Human0.99939280
86P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99305839
87CTCF_27219007_Chip-Seq_Bcells_Human0.99258251
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98560556
89OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97400536
90CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96258436
91MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96032660
92TET1_21490601_ChIP-Seq_MESCs_Mouse0.95194156
93TP53_18474530_ChIP-ChIP_U2OS_Human0.94866526
94AR_25329375_ChIP-Seq_VCAP_Human0.94492434
95TET1_21451524_ChIP-Seq_MESCs_Mouse0.94391107
96ELK3_25401928_ChIP-Seq_HUVEC_Human0.94267634
97P68_20966046_ChIP-Seq_HELA_Human0.94103690
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93921721
99SMAD3_21741376_ChIP-Seq_EPCs_Human0.93361305
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.93350533
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93035783
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91890318
103LXR_22292898_ChIP-Seq_THP-1_Human0.91760764
104ARNT_22903824_ChIP-Seq_MCF-7_Human0.91063476
105NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90445171
106KDM2B_26808549_Chip-Seq_JURKAT_Human0.90364422
107SA1_27219007_Chip-Seq_ERYTHROID_Human0.90301721
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90209227
109RXR_22108803_ChIP-Seq_LS180_Human0.88727034
110CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88567486
111SMAD4_21741376_ChIP-Seq_HESCs_Human0.88416361
112SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88272949
113TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87994959
114CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87306269
115TP53_23651856_ChIP-Seq_MEFs_Mouse0.87138618
116OCT4_19829295_ChIP-Seq_ESCs_Human0.86854415
117TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85342995
118RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85024293
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84372013
120ISL1_27105846_Chip-Seq_CPCs_Mouse0.84120933
121GATA1_26923725_Chip-Seq_HPCs_Mouse0.84021602
122AHR_22903824_ChIP-Seq_MCF-7_Human0.83876578
123KDM2B_26808549_Chip-Seq_DND41_Human0.83255813
124SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.82954524
125STAT3_23295773_ChIP-Seq_U87_Human0.81961572
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81754138
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81646389
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80711817
129KLF4_19829295_ChIP-Seq_ESCs_Human0.80630395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.09463317
2MP0003880_abnormal_central_pattern3.85394172
3MP0003635_abnormal_synaptic_transmissio3.67161506
4MP0004270_analgesia3.04122930
5MP0002063_abnormal_learning/memory/cond2.88515625
6MP0009745_abnormal_behavioral_response2.65521076
7MP0002064_seizures2.47586622
8MP0004858_abnormal_nervous_system2.43677698
9MP0008438_abnormal_cutaneous_collagen2.43205781
10MP0001968_abnormal_touch/_nociception2.36812668
11MP0002572_abnormal_emotion/affect_behav2.14697146
12MP0005623_abnormal_meninges_morphology2.10506686
13MP0009046_muscle_twitch2.03327565
14MP0009780_abnormal_chondrocyte_physiolo2.00597075
15MP0002272_abnormal_nervous_system1.98088560
16MP0002734_abnormal_mechanical_nocicepti1.94987733
17MP0002736_abnormal_nociception_after1.94489349
18MP0002735_abnormal_chemical_nociception1.92416701
19MP0000751_myopathy1.86441146
20MP0005503_abnormal_tendon_morphology1.84264263
21MP0001501_abnormal_sleep_pattern1.82884556
22MP0003283_abnormal_digestive_organ1.79345684
23MP0005423_abnormal_somatic_nervous1.75446442
24MP0003122_maternal_imprinting1.75030305
25MP0001486_abnormal_startle_reflex1.74775779
26MP0001440_abnormal_grooming_behavior1.71198068
27MP0004811_abnormal_neuron_physiology1.61638239
28MP0000920_abnormal_myelination1.60600100
29MP0003690_abnormal_glial_cell1.58803287
30MP0008569_lethality_at_weaning1.58359362
31MP0000778_abnormal_nervous_system1.58118085
32MP0002184_abnormal_innervation1.52740520
33MP0002249_abnormal_larynx_morphology1.50314878
34MP0005275_abnormal_skin_tensile1.47442866
35MP0000955_abnormal_spinal_cord1.46144717
36MP0003329_amyloid_beta_deposits1.44593953
37MP0002733_abnormal_thermal_nociception1.44155716
38MP0003123_paternal_imprinting1.43814301
39MP0001970_abnormal_pain_threshold1.42057251
40MP0002822_catalepsy1.37277534
41MP0003634_abnormal_glial_cell1.35958395
42MP0002067_abnormal_sensory_capabilities1.32731852
43MP0004145_abnormal_muscle_electrophysio1.29197189
44MP0001346_abnormal_lacrimal_gland1.27237235
45MP0000534_abnormal_ureter_morphology1.23716997
46MP0003787_abnormal_imprinting1.23653149
47MP0002882_abnormal_neuron_morphology1.23145578
48MP0001299_abnormal_eye_distance/1.23035041
49MP0002909_abnormal_adrenal_gland1.20298161
50MP0002557_abnormal_social/conspecific_i1.19059803
51MP0003705_abnormal_hypodermis_morpholog1.19053727
52MP0005409_darkened_coat_color1.16858753
53MP0001958_emphysema1.15079814
54MP0003279_aneurysm1.14275836
55MP0002066_abnormal_motor_capabilities/c1.10385921
56MP0004233_abnormal_muscle_weight1.08956832
57MP0003879_abnormal_hair_cell1.08904149
58MP0001177_atelectasis1.08580217
59MP0003385_abnormal_body_wall1.08055529
60MP0000013_abnormal_adipose_tissue1.07185812
61MP0004885_abnormal_endolymph1.06794973
62MP0002152_abnormal_brain_morphology1.03499657
63MP0002234_abnormal_pharynx_morphology1.02047244
64MP0001348_abnormal_lacrimal_gland0.97808585
65MP0001849_ear_inflammation0.97194222
66MP0006276_abnormal_autonomic_nervous0.96529171
67MP0010386_abnormal_urinary_bladder0.95992172
68MP0003633_abnormal_nervous_system0.95418713
69MP0005386_behavior/neurological_phenoty0.94724419
70MP0004924_abnormal_behavior0.94724419
71MP0004272_abnormal_basement_membrane0.92333345
72MP0003942_abnormal_urinary_system0.91763002
73MP0003075_altered_response_to0.91510335
74MP0003632_abnormal_nervous_system0.90086770
75MP0004484_altered_response_of0.86550352
76MP0002837_dystrophic_cardiac_calcinosis0.86204475
77MP0003137_abnormal_impulse_conducting0.84882999
78MP0000566_synostosis0.83724017
79MP0002108_abnormal_muscle_morphology0.83595354
80MP0000462_abnormal_digestive_system0.83471569
81MP0002089_abnormal_postnatal_growth/wei0.82940558
82MP0001984_abnormal_olfaction0.81519418
83MP0003631_nervous_system_phenotype0.81386602
84MP0004085_abnormal_heartbeat0.80592296
85MP0003861_abnormal_nervous_system0.80559293
86MP0004215_abnormal_myocardial_fiber0.80023216
87MP0008961_abnormal_basal_metabolism0.79176715
88MP0003119_abnormal_digestive_system0.79164534
89MP0001963_abnormal_hearing_physiology0.77888970
90MP0000604_amyloidosis0.77611928
91MP0000747_muscle_weakness0.77294432
92MP0001905_abnormal_dopamine_level0.77084724
93MP0000003_abnormal_adipose_tissue0.76549865
94MP0010234_abnormal_vibrissa_follicle0.75128952
95MP0005646_abnormal_pituitary_gland0.73891988
96MP0004130_abnormal_muscle_cell0.73369128
97MP0000569_abnormal_digit_pigmentation0.72927114
98MP0003121_genomic_imprinting0.71632823
99MP0008874_decreased_physiological_sensi0.71238521
100MP0001502_abnormal_circadian_rhythm0.69734552
101MP0003091_abnormal_cell_migration0.68617456
102MP0005171_absent_coat_pigmentation0.68531452
103MP0005167_abnormal_blood-brain_barrier0.67819767
104MP0003115_abnormal_respiratory_system0.67672411
105MP0009250_abnormal_appendicular_skeleto0.66950669
106MP0002069_abnormal_eating/drinking_beha0.66339021
107MP0002295_abnormal_pulmonary_circulatio0.66142981
108MP0000759_abnormal_skeletal_muscle0.65499888
109MP0003045_fibrosis0.65273018
110MP0005187_abnormal_penis_morphology0.64936373
111MP0010030_abnormal_orbit_morphology0.64456055
112MP0003172_abnormal_lysosome_physiology0.63682567
113MP0000681_abnormal_thyroid_gland0.63583866
114MP0000579_abnormal_nail_morphology0.63577355
115MP0000049_abnormal_middle_ear0.63450092
116MP0002653_abnormal_ependyma_morphology0.63209128
117MP0002896_abnormal_bone_mineralization0.62810225
118MP0000537_abnormal_urethra_morphology0.62393607
119MP0002229_neurodegeneration0.61802645
120MP0005508_abnormal_skeleton_morphology0.61425843
121MP0000733_abnormal_muscle_development0.61206262
122MP0010368_abnormal_lymphatic_system0.61059414
123MP0004510_myositis0.61031852
124MP0005257_abnormal_intraocular_pressure0.60460377
125MP0003938_abnormal_ear_development0.60338087
126MP0004036_abnormal_muscle_relaxation0.60146843
127MP0005595_abnormal_vascular_smooth0.60063750
128MP0001943_abnormal_respiration0.60061488

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.42889491
2Focal motor seizures (HP:0011153)5.35709116
3Focal seizures (HP:0007359)4.17014036
4Protrusio acetabuli (HP:0003179)4.08125644
5Visual hallucinations (HP:0002367)3.61267321
6Abnormality of the lower motor neuron (HP:0002366)3.44153983
7Neurofibrillary tangles (HP:0002185)3.39617373
8Atonic seizures (HP:0010819)3.37909382
9Shallow orbits (HP:0000586)3.34053423
10Epileptic encephalopathy (HP:0200134)3.12159443
11Action tremor (HP:0002345)3.11211470
12Abnormality of binocular vision (HP:0011514)3.05921543
13Diplopia (HP:0000651)3.05921543
14Progressive cerebellar ataxia (HP:0002073)3.04303490
15Premature rupture of membranes (HP:0001788)3.01101784
16Broad metatarsal (HP:0001783)2.92633639
17Spastic gait (HP:0002064)2.76777959
18Febrile seizures (HP:0002373)2.73194390
19Absence seizures (HP:0002121)2.68368132
20Bladder diverticulum (HP:0000015)2.60131957
21Amblyopia (HP:0000646)2.57942671
22Impaired vibration sensation in the lower limbs (HP:0002166)2.54671461
23Ankle contracture (HP:0006466)2.54187981
24Pointed chin (HP:0000307)2.48521266
25Generalized tonic-clonic seizures (HP:0002069)2.47329357
26Bowel diverticulosis (HP:0005222)2.47117536
27Insomnia (HP:0100785)2.45194684
28Dialeptic seizures (HP:0011146)2.42404250
29Depression (HP:0000716)2.41963276
30Cerebral aneurysm (HP:0004944)2.39952809
31Annular pancreas (HP:0001734)2.37716830
32Supranuclear gaze palsy (HP:0000605)2.36446090
33Increased variability in muscle fiber diameter (HP:0003557)2.35091328
34Hypoventilation (HP:0002791)2.32002055
35Dilatation of the ascending aorta (HP:0005111)2.30008909
36Aortic dissection (HP:0002647)2.25418954
37Mild short stature (HP:0003502)2.23275848
38Type 1 muscle fiber predominance (HP:0003803)2.22828546
39Tetraplegia (HP:0002445)2.19540270
40Abnormality of dentin (HP:0010299)2.18691046
41Ventricular fibrillation (HP:0001663)2.18456966
42Dysdiadochokinesis (HP:0002075)2.18104913
43Dysmetria (HP:0001310)2.17544105
44Buphthalmos (HP:0000557)2.17120481
45Papilledema (HP:0001085)2.16663669
46Craniofacial dystonia (HP:0012179)2.14859807
47Cerebral hypomyelination (HP:0006808)2.11858952
48Arterial tortuosity (HP:0005116)2.11630825
49Mildly elevated creatine phosphokinase (HP:0008180)2.10799111
50Impaired smooth pursuit (HP:0007772)2.10498811
51Genetic anticipation (HP:0003743)2.09510419
52Intention tremor (HP:0002080)2.08886429
53Genu recurvatum (HP:0002816)2.08341603
54Sleep apnea (HP:0010535)2.07329554
55Ankle clonus (HP:0011448)2.07203037
56Neonatal short-limb short stature (HP:0008921)2.07043439
57Aortic aneurysm (HP:0004942)2.06876144
58Achilles tendon contracture (HP:0001771)2.04893586
59Hemiplegia (HP:0002301)2.04407636
60Akinesia (HP:0002304)2.03604005
61Gaze-evoked nystagmus (HP:0000640)2.02988914
62Renal duplication (HP:0000075)2.00827196
63Spinal canal stenosis (HP:0003416)2.00268624
64Neoplasm of the heart (HP:0100544)2.00178646
65Peripheral hypomyelination (HP:0007182)1.99650098
66Broad-based gait (HP:0002136)1.98712462
67Poor eye contact (HP:0000817)1.96994921
68Hammertoe (HP:0001765)1.95441975
69Torticollis (HP:0000473)1.95381407
70Truncal ataxia (HP:0002078)1.95192333
71Mitral valve prolapse (HP:0001634)1.92676739
72Lower limb muscle weakness (HP:0007340)1.92220379
73Lower limb amyotrophy (HP:0007210)1.91032130
74Bronchomalacia (HP:0002780)1.90991152
75Postural instability (HP:0002172)1.90256738
76Ulnar bowing (HP:0003031)1.90036938
77Urinary urgency (HP:0000012)1.89711598
78Abnormality of skeletal muscle fiber size (HP:0012084)1.89587654
79Atrophic scars (HP:0001075)1.89028014
80Narrow nasal bridge (HP:0000446)1.88813833
81Aplasia involving bones of the extremities (HP:0009825)1.88592729
82Aplasia involving bones of the upper limbs (HP:0009823)1.88592729
83Aplasia of the phalanges of the hand (HP:0009802)1.88592729
84Overgrowth (HP:0001548)1.88320509
85Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.87027877
86Bundle branch block (HP:0011710)1.86974721
87Turricephaly (HP:0000262)1.86036860
88Hyperacusis (HP:0010780)1.85621830
89Hand muscle atrophy (HP:0009130)1.85605371
90Neuronal loss in central nervous system (HP:0002529)1.84827015
91Clonus (HP:0002169)1.84386668
92Urinary bladder sphincter dysfunction (HP:0002839)1.84079268
93Megalencephaly (HP:0001355)1.83772942
94Overriding aorta (HP:0002623)1.83678680
95Impaired social interactions (HP:0000735)1.83629453
96Abnormal social behavior (HP:0012433)1.83629453
97Hyperextensible skin (HP:0000974)1.82311912
98Flat cornea (HP:0007720)1.81548847
99Ankyloglossia (HP:0010296)1.81425601
100Biconcave vertebral bodies (HP:0004586)1.80905619
101Focal dystonia (HP:0004373)1.80474083
102Anxiety (HP:0000739)1.80334831
103Abnormal eating behavior (HP:0100738)1.79389240
104Wormian bones (HP:0002645)1.78906800
105Termporal pattern (HP:0011008)1.78039890
106Insidious onset (HP:0003587)1.78039890
107Slender build (HP:0001533)1.77550929
108Fragile skin (HP:0001030)1.77173465
109Abnormality of ocular smooth pursuit (HP:0000617)1.77079690
110Dysmetric saccades (HP:0000641)1.75756586
111Mitral regurgitation (HP:0001653)1.75253142
112Hydroureter (HP:0000072)1.74970437
113Vascular tortuosity (HP:0004948)1.74941798
114Follicular hyperkeratosis (HP:0007502)1.74410242
115Delusions (HP:0000746)1.74199941
116Scanning speech (HP:0002168)1.74090601
117Coronal craniosynostosis (HP:0004440)1.73761704
118Hemiparesis (HP:0001269)1.73605460
119Renovascular hypertension (HP:0100817)1.73260582
120Thin ribs (HP:0000883)1.73245964
121Elfin facies (HP:0004428)1.72756824
122Deviation of the hallux (HP:0010051)1.72309394
123Upper limb amyotrophy (HP:0009129)1.72108217
124Distal upper limb amyotrophy (HP:0007149)1.72108217
125Abnormality of the Achilles tendon (HP:0005109)1.71131957
126Obstructive sleep apnea (HP:0002870)1.70750301
127Hypoplasia of the iris (HP:0007676)1.70603571
128Spinal rigidity (HP:0003306)1.69585153
129Foot dorsiflexor weakness (HP:0009027)1.69121271
130Rapidly progressive (HP:0003678)1.67309321
131Congenital glaucoma (HP:0001087)1.67026931
132Limb dystonia (HP:0002451)1.67024028
133Cerebral inclusion bodies (HP:0100314)1.66406813
134Apathy (HP:0000741)1.66370610

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.72446796
2EPHA44.32869767
3MAP3K93.29079555
4PRKD32.94402898
5KSR22.64394741
6PAK62.54838075
7MINK12.53155516
8DDR22.31318572
9DAPK22.25921626
10MAP3K42.25125723
11LATS22.09082862
12CAMKK12.02111392
13KSR11.92835424
14NTRK11.85394580
15PDGFRA1.70675016
16STK381.66211956
17PTK2B1.61273317
18MARK11.50971822
19EEF2K1.48341004
20TRIB31.42233877
21DAPK11.41557008
22NTRK21.41335513
23MAP2K71.40949317
24PLK21.39836971
25MAP2K41.37226816
26CDK51.35572939
27TYRO31.30568054
28SGK2231.30526301
29SGK4941.30526301
30RIPK11.28713175
31PRPF4B1.28327390
32ARAF1.24982577
33MAP3K21.24502665
34PAK31.18034448
35CAMK11.16662883
36SIK21.16149151
37PRKCG1.14993157
38TTN1.14630569
39LMTK21.12193300
40FER1.12069700
41RIPK41.09200184
42DMPK1.07205588
43RAF11.06986842
44GRK51.03502863
45CDK191.00349230
46FGFR20.98346666
47RET0.97436523
48MAP3K70.96795841
49NEK10.96325327
50CDK150.96054571
51CDK180.94741333
52MAP3K120.94321766
53PINK10.94318237
54MAPK120.92339516
55MAP3K130.91989189
56CDK140.90008010
57CAMK2A0.86371868
58PKN20.86343989
59PRKCH0.86232492
60UHMK10.86181961
61CDK11A0.85957380
62MARK20.85662525
63TAOK10.84951807
64ALK0.84106823
65FGFR40.83005961
66SGK20.82461099
67CDC42BPA0.81094659
68BMX0.80603617
69TNIK0.78349688
70PNCK0.76553748
71CAMK2B0.75772522
72CASK0.75597581
73BRSK10.73398092
74NEK60.72554142
75SIK10.71245507
76DAPK30.70722725
77BRAF0.70423493
78MAP2K10.69357475
79PTK20.69277347
80MAPK130.68020723
81MYLK0.67741577
82TESK10.66765407
83PHKG20.66366217
84PHKG10.66366217
85STK110.66163260
86CAMKK20.65729030
87CDK120.64468020
88PAK20.63236773
89FES0.62118704
90ROCK20.60200922
91EPHB20.60072125
92PKN10.59873932
93CAMK40.59359732
94LIMK10.56660273
95MTOR0.54951212
96MOS0.52974843
97PDK10.50536221
98SGK10.50304827
99FGFR10.50042518
100PDPK10.49048152
101ROCK10.48871088
102NME10.48851871
103SCYL20.47772179
104PRKG20.47762325
105MAP3K10.47408270
106CAMK1G0.46072500
107ICK0.45476678
108SMG10.45409544
109PRKD20.44868881
110WNK10.44661063
111TNK20.44267511
112RPS6KA30.43667684
113CAMK2D0.42637207
114MAPK100.42194381
115RPS6KA20.41603005
116FGR0.41111086
117FYN0.40156210
118PDGFRB0.39949609
119DYRK1A0.39506979
120ERBB20.38107919
121CAMK2G0.38011558
122SGK30.37524056

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.00406403
2Long-term potentiation_Homo sapiens_hsa047202.66433429
3Synaptic vesicle cycle_Homo sapiens_hsa047212.66276437
4Circadian entrainment_Homo sapiens_hsa047132.58580394
5Glutamatergic synapse_Homo sapiens_hsa047242.33601735
6Amphetamine addiction_Homo sapiens_hsa050312.33235689
7Olfactory transduction_Homo sapiens_hsa047402.31584166
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25579761
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.20808783
10GABAergic synapse_Homo sapiens_hsa047272.09075034
11Salivary secretion_Homo sapiens_hsa049702.03543807
12Morphine addiction_Homo sapiens_hsa050321.93091536
13Dopaminergic synapse_Homo sapiens_hsa047281.91766256
14Gastric acid secretion_Homo sapiens_hsa049711.90973208
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.90501696
16Insulin secretion_Homo sapiens_hsa049111.85368362
17Oxytocin signaling pathway_Homo sapiens_hsa049211.79029854
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78929817
19Cholinergic synapse_Homo sapiens_hsa047251.75234524
20GnRH signaling pathway_Homo sapiens_hsa049121.65794035
21Calcium signaling pathway_Homo sapiens_hsa040201.59189975
22Long-term depression_Homo sapiens_hsa047301.58477575
23Glioma_Homo sapiens_hsa052141.53199226
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52624710
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47026070
26Gap junction_Homo sapiens_hsa045401.42504745
27Renin secretion_Homo sapiens_hsa049241.39938287
28Taste transduction_Homo sapiens_hsa047421.37716007
29Melanogenesis_Homo sapiens_hsa049161.37246177
30Axon guidance_Homo sapiens_hsa043601.35207089
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.34925364
32Estrogen signaling pathway_Homo sapiens_hsa049151.28718255
33cAMP signaling pathway_Homo sapiens_hsa040241.28577803
34Vitamin B6 metabolism_Homo sapiens_hsa007501.27085247
35Dilated cardiomyopathy_Homo sapiens_hsa054141.24085586
36Cocaine addiction_Homo sapiens_hsa050301.23241166
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20990449
38Serotonergic synapse_Homo sapiens_hsa047261.20084722
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17213855
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.12191037
41ErbB signaling pathway_Homo sapiens_hsa040121.08415620
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07911190
43Oocyte meiosis_Homo sapiens_hsa041141.07107651
44Type II diabetes mellitus_Homo sapiens_hsa049301.06007324
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05310893
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02757112
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98339427
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.97598454
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95679097
50VEGF signaling pathway_Homo sapiens_hsa043700.92391725
51Bile secretion_Homo sapiens_hsa049760.89590910
52Thyroid hormone synthesis_Homo sapiens_hsa049180.87469465
53Cardiac muscle contraction_Homo sapiens_hsa042600.86302708
54Nitrogen metabolism_Homo sapiens_hsa009100.86298288
55Wnt signaling pathway_Homo sapiens_hsa043100.86183749
56Rap1 signaling pathway_Homo sapiens_hsa040150.86059383
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85183319
58Focal adhesion_Homo sapiens_hsa045100.84469815
59Dorso-ventral axis formation_Homo sapiens_hsa043200.83947800
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83684332
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.83089571
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80737093
63mTOR signaling pathway_Homo sapiens_hsa041500.80520790
64Choline metabolism in cancer_Homo sapiens_hsa052310.79777023
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79140642
66MAPK signaling pathway_Homo sapiens_hsa040100.78641930
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76705994
68Proteoglycans in cancer_Homo sapiens_hsa052050.76655366
69Pancreatic secretion_Homo sapiens_hsa049720.75952876
70Glucagon signaling pathway_Homo sapiens_hsa049220.73283557
71ECM-receptor interaction_Homo sapiens_hsa045120.71700041
72Hedgehog signaling pathway_Homo sapiens_hsa043400.70556496
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70165473
74Hippo signaling pathway_Homo sapiens_hsa043900.68403180
75Collecting duct acid secretion_Homo sapiens_hsa049660.68317111
76Vibrio cholerae infection_Homo sapiens_hsa051100.67843085
77Arginine biosynthesis_Homo sapiens_hsa002200.67611609
78Ras signaling pathway_Homo sapiens_hsa040140.66446995
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66116921
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63275090
81Bladder cancer_Homo sapiens_hsa052190.62275765
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61748724
83AMPK signaling pathway_Homo sapiens_hsa041520.61709007
84Endocytosis_Homo sapiens_hsa041440.61325486
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60711224
86Non-small cell lung cancer_Homo sapiens_hsa052230.60668776
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.60547361
88Endometrial cancer_Homo sapiens_hsa052130.60170274
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56766720
90Amoebiasis_Homo sapiens_hsa051460.56378242
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56332324
92Tight junction_Homo sapiens_hsa045300.54950204
93Protein digestion and absorption_Homo sapiens_hsa049740.54161833
94Basal cell carcinoma_Homo sapiens_hsa052170.54073519
95Adherens junction_Homo sapiens_hsa045200.53026705
96Arginine and proline metabolism_Homo sapiens_hsa003300.52726894
97Melanoma_Homo sapiens_hsa052180.52130203
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51910941
99Chronic myeloid leukemia_Homo sapiens_hsa052200.51823377
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.51567625
101Inositol phosphate metabolism_Homo sapiens_hsa005620.49738104
102Insulin signaling pathway_Homo sapiens_hsa049100.48404024
103Notch signaling pathway_Homo sapiens_hsa043300.48274304
104Renal cell carcinoma_Homo sapiens_hsa052110.48051079
105Colorectal cancer_Homo sapiens_hsa052100.47632380
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.47003283
107Prion diseases_Homo sapiens_hsa050200.46647676
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46640630
109Circadian rhythm_Homo sapiens_hsa047100.45165537
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44816907
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44045528
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41948932

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