ARHGEF26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.41167679
2triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.27615488
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.89439518
4L-phenylalanine catabolic process (GO:0006559)4.89439518
5alpha-linolenic acid metabolic process (GO:0036109)4.77683052
6L-phenylalanine metabolic process (GO:0006558)4.56487001
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.56487001
8high-density lipoprotein particle remodeling (GO:0034375)4.54722801
9aromatic amino acid family catabolic process (GO:0009074)4.50931853
10reverse cholesterol transport (GO:0043691)4.47305903
11urea cycle (GO:0000050)4.39580781
12urea metabolic process (GO:0019627)4.39580781
13low-density lipoprotein particle remodeling (GO:0034374)4.39390624
14regulation of cholesterol esterification (GO:0010872)4.30509692
15tryptophan catabolic process (GO:0006569)4.29067934
16indole-containing compound catabolic process (GO:0042436)4.29067934
17indolalkylamine catabolic process (GO:0046218)4.29067934
18bile acid biosynthetic process (GO:0006699)4.24874749
19plasma lipoprotein particle remodeling (GO:0034369)4.19907381
20protein-lipid complex remodeling (GO:0034368)4.19907381
21macromolecular complex remodeling (GO:0034367)4.19907381
22kynurenine metabolic process (GO:0070189)4.07013376
23cellular glucuronidation (GO:0052695)4.04204116
24homocysteine metabolic process (GO:0050667)4.00776414
25cysteine metabolic process (GO:0006534)3.97259180
26dicarboxylic acid biosynthetic process (GO:0043650)3.96408704
27tryptophan metabolic process (GO:0006568)3.92147074
28nitrogen cycle metabolic process (GO:0071941)3.89800523
29cell proliferation in forebrain (GO:0021846)3.78849868
30water-soluble vitamin biosynthetic process (GO:0042364)3.76893428
31serine family amino acid catabolic process (GO:0009071)3.75562433
32regulation of protein activation cascade (GO:2000257)3.75471078
33sulfur amino acid catabolic process (GO:0000098)3.73979003
34regulation of fibrinolysis (GO:0051917)3.72958571
35regulation of bile acid biosynthetic process (GO:0070857)3.72929505
36glutamate metabolic process (GO:0006536)3.72300295
37phospholipid efflux (GO:0033700)3.71979829
38presynaptic membrane assembly (GO:0097105)3.71804532
39bile acid metabolic process (GO:0008206)3.70375019
40cellular modified amino acid catabolic process (GO:0042219)3.65695522
41regulation of triglyceride catabolic process (GO:0010896)3.65043711
42glyoxylate metabolic process (GO:0046487)3.61435250
43presynaptic membrane organization (GO:0097090)3.60835639
44amino-acid betaine metabolic process (GO:0006577)3.59454217
45negative regulation of fibrinolysis (GO:0051918)3.58390707
46uronic acid metabolic process (GO:0006063)3.52180381
47glucuronate metabolic process (GO:0019585)3.52180381
48linoleic acid metabolic process (GO:0043651)3.50615883
49coenzyme catabolic process (GO:0009109)3.48330242
50alpha-amino acid catabolic process (GO:1901606)3.48205603
51negative regulation of sterol transport (GO:0032372)3.47495069
52negative regulation of cholesterol transport (GO:0032375)3.47495069
53regulation of complement activation (GO:0030449)3.45402266
54complement activation, alternative pathway (GO:0006957)3.40705933
55peptidyl-glutamic acid carboxylation (GO:0017187)3.38708075
56protein carboxylation (GO:0018214)3.38708075
57drug catabolic process (GO:0042737)3.33022268
58cholesterol efflux (GO:0033344)3.32684557
59very-low-density lipoprotein particle assembly (GO:0034379)3.32030743
60axon ensheathment in central nervous system (GO:0032291)3.31130937
61central nervous system myelination (GO:0022010)3.31130937
62somite development (GO:0061053)3.29911683
63plasma lipoprotein particle organization (GO:0071827)3.29181040
64plasma lipoprotein particle assembly (GO:0034377)3.27792400
65cellular amino acid catabolic process (GO:0009063)3.26430780
66bile acid and bile salt transport (GO:0015721)3.24237845
67gamma-aminobutyric acid transport (GO:0015812)3.22530449
68regulation of cholesterol biosynthetic process (GO:0045540)3.22328872
69midgut development (GO:0007494)3.21652292
70response to nitrosative stress (GO:0051409)3.21357784
71acylglycerol homeostasis (GO:0055090)3.21013588
72triglyceride homeostasis (GO:0070328)3.21013588
73piRNA metabolic process (GO:0034587)3.20212160
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.19898611
75fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.18866355
76cellular ketone body metabolic process (GO:0046950)3.18706576
77protein polyglutamylation (GO:0018095)3.17421938
78sterol catabolic process (GO:0016127)3.11651457
79cholesterol catabolic process (GO:0006707)3.11651457
80regulation of cholesterol homeostasis (GO:2000188)3.10125045
81transmission of nerve impulse (GO:0019226)3.09619210
82arginine metabolic process (GO:0006525)3.08950380
83positive regulation of fatty acid beta-oxidation (GO:0032000)3.08579183
84aromatic amino acid family metabolic process (GO:0009072)3.08477442
85serotonin metabolic process (GO:0042428)3.08396470
86exogenous drug catabolic process (GO:0042738)3.07792796
87postsynaptic membrane organization (GO:0001941)3.07009154
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.05930924
89amine catabolic process (GO:0009310)3.05098064
90cellular biogenic amine catabolic process (GO:0042402)3.05098064
91phospholipid homeostasis (GO:0055091)3.03799667
92pyrimidine nucleobase catabolic process (GO:0006208)3.02126388
93negative regulation of transcription regulatory region DNA binding (GO:2000678)3.01718832
94flavonoid metabolic process (GO:0009812)3.01688128
95negative regulation of lipase activity (GO:0060192)3.01371069
96retinal ganglion cell axon guidance (GO:0031290)3.01095371
97otic vesicle formation (GO:0030916)3.00863372
98epithelial cilium movement (GO:0003351)3.00837651
99lysine catabolic process (GO:0006554)3.00828546
100lysine metabolic process (GO:0006553)3.00828546
101ovulation cycle (GO:0042698)3.00074365
102protein-lipid complex subunit organization (GO:0071825)2.96763326
103auditory behavior (GO:0031223)2.95757504
104negative regulation of sodium ion transport (GO:0010766)2.95265822
105dicarboxylic acid catabolic process (GO:0043649)2.95232047
106nonmotile primary cilium assembly (GO:0035058)2.94484991
107positive regulation of lipid catabolic process (GO:0050996)2.93089041
108negative regulation of protein activation cascade (GO:2000258)2.92726535
109primary amino compound metabolic process (GO:1901160)2.92324426
110cellular response to cholesterol (GO:0071397)2.90503886
111serine family amino acid metabolic process (GO:0009069)2.89443477
112negative regulation of astrocyte differentiation (GO:0048712)2.89175095
113tyrosine metabolic process (GO:0006570)2.89168447
114serine family amino acid biosynthetic process (GO:0009070)2.87335652
115imidazole-containing compound metabolic process (GO:0052803)2.87063563
116intestinal cholesterol absorption (GO:0030299)2.85938493
117alanine transport (GO:0032328)2.85558031
118negative regulation of appetite (GO:0032099)2.84337348
119negative regulation of response to food (GO:0032096)2.84337348
120carnitine metabolic process (GO:0009437)2.83964978
121neurotransmitter-gated ion channel clustering (GO:0072578)2.83645091
122indolalkylamine metabolic process (GO:0006586)2.82868981
123sulfation (GO:0051923)2.81923897
124benzene-containing compound metabolic process (GO:0042537)2.80383228
125establishment of protein localization to mitochondrial membrane (GO:0090151)2.80223215
126fructose metabolic process (GO:0006000)2.79729879
127C4-dicarboxylate transport (GO:0015740)2.77705860
128neuronal action potential (GO:0019228)2.75276047
129indole-containing compound metabolic process (GO:0042430)2.72623651
130detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.71548059
131cilium movement (GO:0003341)2.71435783
132regulation of mesoderm development (GO:2000380)2.69427717
133neuron cell-cell adhesion (GO:0007158)2.68506556
134mechanosensory behavior (GO:0007638)2.67809071
135regulation of action potential (GO:0098900)2.67343127
136axoneme assembly (GO:0035082)2.66643494
137spinal cord development (GO:0021510)2.65950198
138limb development (GO:0060173)2.63999114
139appendage development (GO:0048736)2.63999114
140protein complex biogenesis (GO:0070271)2.61049740
141intraciliary transport (GO:0042073)2.56909797
142nucleobase catabolic process (GO:0046113)2.55916193
143pharyngeal system development (GO:0060037)2.55446440
144DNA methylation involved in gamete generation (GO:0043046)2.54882733
145detection of light stimulus involved in sensory perception (GO:0050962)2.53036219
146detection of light stimulus involved in visual perception (GO:0050908)2.53036219
147limb bud formation (GO:0060174)2.52459310
148negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51367620
149photoreceptor cell development (GO:0042461)2.48105810
150mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.47817903
151mitochondrial respiratory chain complex I assembly (GO:0032981)2.47817903
152NADH dehydrogenase complex assembly (GO:0010257)2.47817903
153dorsal/ventral pattern formation (GO:0009953)2.46522856
154positive regulation of potassium ion transmembrane transport (GO:1901381)2.44765729
155oxidative demethylation (GO:0070989)2.44486888
156lateral sprouting from an epithelium (GO:0060601)2.43249328
157negative regulation of glial cell differentiation (GO:0045686)2.41416157
158positive regulation of meiosis (GO:0045836)2.41336075
159synaptic transmission, cholinergic (GO:0007271)2.41200171
160kidney morphogenesis (GO:0060993)2.41104439
161regulation of neurotransmitter uptake (GO:0051580)2.36184845
162spinal cord motor neuron differentiation (GO:0021522)2.35722456
163reflex (GO:0060004)2.35082326
164protein localization to synapse (GO:0035418)2.33974990
165axonemal dynein complex assembly (GO:0070286)2.33048382
166mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.32594700
167positive regulation of action potential (GO:0045760)2.30638761
168negative regulation of systemic arterial blood pressure (GO:0003085)2.30564242
169epithelial cell maturation (GO:0002070)2.29921887
170mitochondrial respiratory chain complex assembly (GO:0033108)2.28985993
171action potential (GO:0001508)2.27888377
172positive regulation of meiotic cell cycle (GO:0051446)2.26914145
173parturition (GO:0007567)2.26718022
174G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.26445772
175cellular response to sterol (GO:0036315)2.25819680
176regulation of cilium movement (GO:0003352)2.25202966
177eye photoreceptor cell development (GO:0042462)2.24977622
178cilium organization (GO:0044782)2.23517377
179pituitary gland development (GO:0021983)2.23388897
180DNA deamination (GO:0045006)2.23258715
181cilium or flagellum-dependent cell motility (GO:0001539)2.22343192
182regulation of rhodopsin mediated signaling pathway (GO:0022400)2.21194588
183tongue development (GO:0043586)2.20080719
184response to auditory stimulus (GO:0010996)2.19847792
185artery development (GO:0060840)2.19549226

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.53444465
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.83028378
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.24214684
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.07023280
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.04188081
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.87057250
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.71328241
8VDR_22108803_ChIP-Seq_LS180_Human2.67419387
9ZNF274_21170338_ChIP-Seq_K562_Hela2.58703675
10IGF1R_20145208_ChIP-Seq_DFB_Human2.52786196
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.34911379
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30774039
13GBX2_23144817_ChIP-Seq_PC3_Human2.25201740
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10027948
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.08654336
16EZH2_22144423_ChIP-Seq_EOC_Human2.04897974
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03061917
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.02528161
19FUS_26573619_Chip-Seq_HEK293_Human2.00048134
20EWS_26573619_Chip-Seq_HEK293_Human1.99938908
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96148928
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.83588888
23AR_21572438_ChIP-Seq_LNCaP_Human1.78266756
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75913929
25RNF2_27304074_Chip-Seq_NSC_Mouse1.73713657
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70173012
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70173012
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67537922
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.66550526
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.65733016
31IRF1_19129219_ChIP-ChIP_H3396_Human1.64632177
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62602763
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.59223257
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58266904
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.55741943
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53545894
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52899009
38ER_23166858_ChIP-Seq_MCF-7_Human1.52676742
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.48298056
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.42999743
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42925062
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42610746
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39387105
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39316383
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.38569302
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37762281
47DROSHA_22980978_ChIP-Seq_HELA_Human1.37090749
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36177300
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36047653
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.35367085
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34805516
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32492620
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32331309
54CBP_20019798_ChIP-Seq_JUKART_Human1.30480801
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30480801
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.30337267
57P300_19829295_ChIP-Seq_ESCs_Human1.29900768
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29404393
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29348298
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29231492
61BCAT_22108803_ChIP-Seq_LS180_Human1.28814152
62* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28566932
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28539690
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.26562660
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.26460671
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25855289
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25071244
68TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.24521508
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23256211
70TCF4_23295773_ChIP-Seq_U87_Human1.22985908
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22415732
72REST_21632747_ChIP-Seq_MESCs_Mouse1.22124988
73RUNX2_22187159_ChIP-Seq_PCA_Human1.21743460
74SMAD4_21799915_ChIP-Seq_A2780_Human1.21216818
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19826157
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18650549
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18571098
78FOXA2_19822575_ChIP-Seq_HepG2_Human1.17732899
79TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.17575944
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.16773163
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16191949
82AR_25329375_ChIP-Seq_VCAP_Human1.13439291
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.13269289
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.11858787
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11851453
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11654032
87AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11575497
88TP53_18474530_ChIP-ChIP_U2OS_Human1.11360394
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.10912618
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10876858
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10377018
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09741873
93HTT_18923047_ChIP-ChIP_STHdh_Human1.06492080
94SMAD3_21741376_ChIP-Seq_HESCs_Human1.06153492
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05878355
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05044576
97TAL1_26923725_Chip-Seq_HPCs_Mouse1.04883937
98STAT3_23295773_ChIP-Seq_U87_Human1.04825809
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.03912704
100MYC_18940864_ChIP-ChIP_HL60_Human1.03705997
101TAF15_26573619_Chip-Seq_HEK293_Human1.03384025
102AHR_22903824_ChIP-Seq_MCF-7_Human1.02677471
103RXR_22108803_ChIP-Seq_LS180_Human1.02188419
104NOTCH1_21737748_ChIP-Seq_TLL_Human1.01847519
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01616715
106PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00615810
107FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00117310
108FOXA1_25329375_ChIP-Seq_VCAP_Human1.00117310
109REST_18959480_ChIP-ChIP_MESCs_Mouse1.00116193
110NANOG_19829295_ChIP-Seq_ESCs_Human0.99702532
111SOX2_19829295_ChIP-Seq_ESCs_Human0.99702532
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99676054
113SMAD4_21741376_ChIP-Seq_EPCs_Human0.99295710
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99292116
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99292116
116JUN_21703547_ChIP-Seq_K562_Human0.98782452
117AR_19668381_ChIP-Seq_PC3_Human0.98581438
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.98051279
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97953411
120RING1B_27294783_Chip-Seq_ESCs_Mouse0.97518624
121SOX2_21211035_ChIP-Seq_LN229_Gbm0.97035284
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96967261
123SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96854809
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96803870
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96803870
126TCF4_18268006_ChIP-ChIP_LS174T_Human0.96018488
127ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94548685
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94394949
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93497028
130SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93402515
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92062869
132TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91136550
133AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91010580
134SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90272642
135POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89470199
136TP53_16413492_ChIP-PET_HCT116_Human0.88193364
137NANOG_18555785_Chip-Seq_ESCs_Mouse0.87547399
138E2F1_18555785_Chip-Seq_ESCs_Mouse0.87094850
139EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86751251
140TRIM28_21343339_ChIP-Seq_HEK293_Human0.86511499
141TCF4_22108803_ChIP-Seq_LS180_Human0.85432629
142OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85135074
143FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84636102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.96663489
2MP0005360_urolithiasis5.51933547
3MP0005085_abnormal_gallbladder_physiolo4.94191845
4MP0005365_abnormal_bile_salt4.70538848
5MP0008875_abnormal_xenobiotic_pharmacok4.16981491
6MP0003252_abnormal_bile_duct3.10851457
7MP0003011_delayed_dark_adaptation3.02959765
8MP0010329_abnormal_lipoprotein_level2.88005552
9MP0005083_abnormal_biliary_tract2.40700952
10MP0002653_abnormal_ependyma_morphology2.40260009
11MP0003880_abnormal_central_pattern2.38488581
12MP0002254_reproductive_system_inflammat2.34529156
13MP0005332_abnormal_amino_acid2.28341012
14MP0001666_abnormal_nutrient_absorption2.20095918
15MP0003806_abnormal_nucleotide_metabolis2.15107432
16MP0005551_abnormal_eye_electrophysiolog2.14822797
17MP0005423_abnormal_somatic_nervous2.07353198
18MP0009840_abnormal_foam_cell2.05357903
19MP0001485_abnormal_pinna_reflex2.00859406
20MP0004019_abnormal_vitamin_homeostasis1.97540358
21MP0008877_abnormal_DNA_methylation1.93288603
22MP0000566_synostosis1.91683495
23MP0009379_abnormal_foot_pigmentation1.88086930
24MP0002160_abnormal_reproductive_system1.88086333
25MP0000631_abnormal_neuroendocrine_gland1.83072103
26MP0003646_muscle_fatigue1.81785951
27MP0003868_abnormal_feces_composition1.80819665
28MP0005646_abnormal_pituitary_gland1.78903403
29MP0005248_abnormal_Harderian_gland1.76546371
30MP0002837_dystrophic_cardiac_calcinosis1.75901597
31MP0004859_abnormal_synaptic_plasticity1.75403120
32MP0003690_abnormal_glial_cell1.69983566
33MP0002876_abnormal_thyroid_physiology1.53893207
34MP0002118_abnormal_lipid_homeostasis1.53866742
35MP0002102_abnormal_ear_morphology1.48998389
36MP0004885_abnormal_endolymph1.47564487
37MP0009384_cardiac_valve_regurgitation1.46885987
38MP0004145_abnormal_muscle_electrophysio1.44933903
39MP0005389_reproductive_system_phenotype1.43424724
40MP0000049_abnormal_middle_ear1.42472231
41MP0009780_abnormal_chondrocyte_physiolo1.42277329
42MP0001984_abnormal_olfaction1.40173339
43MP0002735_abnormal_chemical_nociception1.39972580
44MP0006276_abnormal_autonomic_nervous1.39503272
45MP0004858_abnormal_nervous_system1.37598499
46MP0002938_white_spotting1.37039275
47MP0000537_abnormal_urethra_morphology1.36290055
48MP0002138_abnormal_hepatobiliary_system1.34032396
49MP0004133_heterotaxia1.33050906
50MP0004742_abnormal_vestibular_system1.31851563
51MP0008789_abnormal_olfactory_epithelium1.31254370
52MP0005647_abnormal_sex_gland1.30283645
53MP0001486_abnormal_startle_reflex1.28905673
54MP0001502_abnormal_circadian_rhythm1.26748172
55MP0003123_paternal_imprinting1.24755747
56MP0004142_abnormal_muscle_tone1.24395500
57MP0005253_abnormal_eye_physiology1.23523666
58MP0003119_abnormal_digestive_system1.21628240
59MP0003937_abnormal_limbs/digits/tail_de1.18226076
60MP0002822_catalepsy1.18000848
61MP0000778_abnormal_nervous_system1.17835148
62MP0001293_anophthalmia1.17797407
63MP0002063_abnormal_learning/memory/cond1.17605546
64MP0002184_abnormal_innervation1.17594071
65MP0002234_abnormal_pharynx_morphology1.16440620
66MP0002090_abnormal_vision1.16353227
67MP0003121_genomic_imprinting1.15953495
68MP0003191_abnormal_cellular_cholesterol1.15361237
69MP0009697_abnormal_copulation1.15056379
70MP0002736_abnormal_nociception_after1.14950928
71MP0000955_abnormal_spinal_cord1.13224660
72MP0010234_abnormal_vibrissa_follicle1.13075685
73MP0000609_abnormal_liver_physiology1.12041212
74MP0003787_abnormal_imprinting1.11456171
75MP0001919_abnormal_reproductive_system1.11157718
76MP0003635_abnormal_synaptic_transmissio1.10987660
77MP0003283_abnormal_digestive_organ1.10777334
78MP0003136_yellow_coat_color1.08368063
79MP0001764_abnormal_homeostasis1.07740692
80MP0003938_abnormal_ear_development1.07009651
81MP0006292_abnormal_olfactory_placode1.06552132
82MP0009745_abnormal_behavioral_response1.06197877
83MP0009250_abnormal_appendicular_skeleto1.05752130
84MP0001501_abnormal_sleep_pattern1.05204791
85MP0002282_abnormal_trachea_morphology1.05017573
86MP0001970_abnormal_pain_threshold1.04212923
87MP0004270_analgesia1.04202830
88MP0001529_abnormal_vocalization1.02291534
89MP0005084_abnormal_gallbladder_morpholo1.00735397
90MP0002249_abnormal_larynx_morphology1.00179547
91MP0005167_abnormal_blood-brain_barrier0.98328775
92MP0001177_atelectasis0.98007608
93MP0002928_abnormal_bile_duct0.97498051
94MP0002733_abnormal_thermal_nociception0.97368019
95MP0003195_calcinosis0.96263755
96MP0000383_abnormal_hair_follicle0.95510218
97MP0005319_abnormal_enzyme/_coenzyme0.94417378
98MP0005645_abnormal_hypothalamus_physiol0.93407547
99MP0005187_abnormal_penis_morphology0.92091306
100MP0002277_abnormal_respiratory_mucosa0.91945409
101MP0001968_abnormal_touch/_nociception0.91393838
102MP0005195_abnormal_posterior_eye0.89794931
103MP0002572_abnormal_emotion/affect_behav0.89672647
104MP0002163_abnormal_gland_morphology0.85792552
105MP0003879_abnormal_hair_cell0.85406543
106MP0008995_early_reproductive_senescence0.85206505
107MP0005394_taste/olfaction_phenotype0.84708115
108MP0005499_abnormal_olfactory_system0.84708115
109MP0001440_abnormal_grooming_behavior0.84519483
110MP0002064_seizures0.83965321
111MP0005584_abnormal_enzyme/coenzyme_acti0.82789513
112MP0002751_abnormal_autonomic_nervous0.82721813
113MP0005379_endocrine/exocrine_gland_phen0.82413637
114MP0000579_abnormal_nail_morphology0.82170611
115MP0002557_abnormal_social/conspecific_i0.82123763
116MP0003878_abnormal_ear_physiology0.81979598
117MP0005377_hearing/vestibular/ear_phenot0.81979598
118MP0001986_abnormal_taste_sensitivity0.81878935
119MP0000647_abnormal_sebaceous_gland0.81159209
120MP0003329_amyloid_beta_deposits0.79343558
121MP0003936_abnormal_reproductive_system0.79140608
122MP0000427_abnormal_hair_cycle0.79059970
123MP0008872_abnormal_physiological_respon0.77630475
124MP0004130_abnormal_muscle_cell0.74549874
125MP0002638_abnormal_pupillary_reflex0.73782302
126MP0010368_abnormal_lymphatic_system0.72419282
127MP0003633_abnormal_nervous_system0.71532436
128MP0002067_abnormal_sensory_capabilities0.70988745
129MP0000026_abnormal_inner_ear0.70849138
130MP0009053_abnormal_anal_canal0.67667250
131MP0005595_abnormal_vascular_smooth0.67482581
132MP0009046_muscle_twitch0.66721085
133MP0003632_abnormal_nervous_system0.65566951
134MP0010030_abnormal_orbit_morphology0.64154478
135MP0006072_abnormal_retinal_apoptosis0.64052165
136MP0005670_abnormal_white_adipose0.63963443
137MP0009764_decreased_sensitivity_to0.63758789
138MP0004782_abnormal_surfactant_physiolog0.63399792
139MP0005220_abnormal_exocrine_pancreas0.61518307
140MP0003631_nervous_system_phenotype0.61379510
141MP0003634_abnormal_glial_cell0.61088803
142MP0002734_abnormal_mechanical_nocicepti0.60777086
143MP0000604_amyloidosis0.60606518
144MP0005391_vision/eye_phenotype0.58445520
145MP0002882_abnormal_neuron_morphology0.56139246
146MP0002752_abnormal_somatic_nervous0.55702548
147MP0001324_abnormal_eye_pigmentation0.55455693
148MP0002229_neurodegeneration0.55315771
149MP0003890_abnormal_embryonic-extraembry0.54360676
150MP0003075_altered_response_to0.54351128
151MP0001963_abnormal_hearing_physiology0.53575738
152MP0002272_abnormal_nervous_system0.51861063
153MP0003638_abnormal_response/metabolism_0.51535801

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.46594776
2Deep venous thrombosis (HP:0002625)5.40625170
3Prolonged partial thromboplastin time (HP:0003645)4.86530619
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.69928853
5Hypobetalipoproteinemia (HP:0003563)4.57005791
6Hyperlipoproteinemia (HP:0010980)4.52267141
7Xanthomatosis (HP:0000991)4.39522532
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.38720982
9Hypoalphalipoproteinemia (HP:0003233)4.16900321
10Aplasia involving bones of the extremities (HP:0009825)4.12547412
11Aplasia involving bones of the upper limbs (HP:0009823)4.12547412
12Aplasia of the phalanges of the hand (HP:0009802)4.12547412
13Hypolipoproteinemia (HP:0010981)4.07388546
14Hyperglycinemia (HP:0002154)3.88147392
15Hyperglycinuria (HP:0003108)3.70459079
16Hyperammonemia (HP:0001987)3.68433930
17Complement deficiency (HP:0004431)3.57868667
18Chorioretinal atrophy (HP:0000533)3.54337852
19True hermaphroditism (HP:0010459)3.51527696
20Abnormality of glycine metabolism (HP:0010895)3.50669732
21Abnormality of serine family amino acid metabolism (HP:0010894)3.50669732
22Epidermoid cyst (HP:0200040)3.48660035
23Pancreatic cysts (HP:0001737)3.46171928
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.45028692
25Pancreatic fibrosis (HP:0100732)3.38314431
26Fibular aplasia (HP:0002990)3.33691221
27Nephronophthisis (HP:0000090)3.32293080
28Abnormality of methionine metabolism (HP:0010901)3.31272070
29Fat malabsorption (HP:0002630)3.29453412
30Abnormality of sulfur amino acid metabolism (HP:0004339)3.17821760
31Conjugated hyperbilirubinemia (HP:0002908)3.12678281
32Abnormality of midbrain morphology (HP:0002418)3.07842185
33Molar tooth sign on MRI (HP:0002419)3.07842185
34Ketosis (HP:0001946)3.03746190
35Abnormality of aspartate family amino acid metabolism (HP:0010899)3.03604241
36Joint hemorrhage (HP:0005261)3.00016905
37Abnormality of glutamine family amino acid metabolism (HP:0010902)2.99668335
38Pigmentary retinal degeneration (HP:0001146)2.94546716
39Abnormality of the common coagulation pathway (HP:0010990)2.86576853
40Hyperventilation (HP:0002883)2.83685733
41Pendular nystagmus (HP:0012043)2.78793996
42Abnormality of the renal medulla (HP:0100957)2.78056266
43Hypercholesterolemia (HP:0003124)2.69916752
44Humeroradial synostosis (HP:0003041)2.64912866
45Synostosis involving the elbow (HP:0003938)2.64912866
46Delayed CNS myelination (HP:0002188)2.60118261
47Abnormality of pyrimidine metabolism (HP:0004353)2.60094423
48Megalencephaly (HP:0001355)2.57714815
49Medial flaring of the eyebrow (HP:0010747)2.57627328
50Vascular calcification (HP:0004934)2.54119585
51Chronic hepatic failure (HP:0100626)2.53695918
52Spontaneous abortion (HP:0005268)2.53298845
53Type II lissencephaly (HP:0007260)2.52710592
54Bile duct proliferation (HP:0001408)2.50085899
55Abnormal biliary tract physiology (HP:0012439)2.50085899
56Steatorrhea (HP:0002570)2.48960403
57Status epilepticus (HP:0002133)2.47143332
58Progressive cerebellar ataxia (HP:0002073)2.45472596
59Septo-optic dysplasia (HP:0100842)2.45125574
60Abnormality of the middle phalanges of the toes (HP:0010183)2.43190557
61Hepatocellular carcinoma (HP:0001402)2.41759265
62Abnormality of the renal cortex (HP:0011035)2.40546481
63Ketoacidosis (HP:0001993)2.39279694
64Confusion (HP:0001289)2.38310860
65Abnormality of the proximal phalanges of the hand (HP:0009834)2.36250593
66Genetic anticipation (HP:0003743)2.31039357
67Cystic liver disease (HP:0006706)2.30831436
68Aplasia/Hypoplasia of the tibia (HP:0005772)2.30143632
69Congenital stationary night blindness (HP:0007642)2.29263262
70Enlarged kidneys (HP:0000105)2.28702356
71Sclerocornea (HP:0000647)2.28589673
72Congenital, generalized hypertrichosis (HP:0004540)2.27159775
73Abnormality of complement system (HP:0005339)2.26325683
74Hypoglycemic seizures (HP:0002173)2.24316091
75Sensorimotor neuropathy (HP:0007141)2.22918195
76Abnormality of the intrinsic pathway (HP:0010989)2.20077348
77Abnormal ciliary motility (HP:0012262)2.19752939
78Male pseudohermaphroditism (HP:0000037)2.19579740
79Abnormal respiratory motile cilium morphology (HP:0005938)2.19075924
80Abnormal respiratory epithelium morphology (HP:0012253)2.19075924
81Spastic diplegia (HP:0001264)2.18916432
82Oligodactyly (hands) (HP:0001180)2.17955127
83Short tibia (HP:0005736)2.17872244
84Abnormal respiratory motile cilium physiology (HP:0012261)2.17133624
85Abnormality of the nasal septum (HP:0000419)2.16992731
86Concave nail (HP:0001598)2.16648342
87Hypoglycemic coma (HP:0001325)2.16564354
88Gait imbalance (HP:0002141)2.16273968
89Abnormality of serum amino acid levels (HP:0003112)2.16022238
90Cardiovascular calcification (HP:0011915)2.15326562
91Methylmalonic acidemia (HP:0002912)2.13223012
92Hepatoblastoma (HP:0002884)2.10549885
93Hypoplasia of the ulna (HP:0003022)2.10201246
94Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.10057517
95Dynein arm defect of respiratory motile cilia (HP:0012255)2.09631198
96Absent/shortened dynein arms (HP:0200106)2.09631198
97Hemiparesis (HP:0001269)2.07137520
98Congenital primary aphakia (HP:0007707)2.06951022
99Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.06264973
100Morphological abnormality of the middle ear (HP:0008609)2.05248218
101Neonatal hypoglycemia (HP:0001998)2.05049588
102Increased corneal curvature (HP:0100692)2.04690875
103Keratoconus (HP:0000563)2.04690875
104Anophthalmia (HP:0000528)2.04661341
105Genital tract atresia (HP:0001827)2.04255848
106Tubular atrophy (HP:0000092)2.04048933
107Anencephaly (HP:0002323)2.03463869
108Abnormal rod and cone electroretinograms (HP:0008323)2.03369589
109Rib fusion (HP:0000902)2.02443327
110Abnormality of nucleobase metabolism (HP:0010932)2.02132103
111Postaxial foot polydactyly (HP:0001830)2.02073285
112Aplasia/Hypoplasia of the ulna (HP:0006495)2.01781299
113Asplenia (HP:0001746)2.00640503
114Abnormality of the phalanges of the 5th finger (HP:0004213)2.00606848
115Hypochromic microcytic anemia (HP:0004840)2.00494669
116Abnormality of the axillary hair (HP:0100134)2.00448058
117Abnormality of secondary sexual hair (HP:0009888)2.00448058
118Vaginal atresia (HP:0000148)1.99741962
119Optic nerve hypoplasia (HP:0000609)1.99315529
120Aplasia/Hypoplasia of the spleen (HP:0010451)1.98363224
121Synostosis of carpal bones (HP:0005048)1.97755775
122Polydipsia (HP:0001959)1.96141547
123Abnormal drinking behavior (HP:0030082)1.96141547
124Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95428211
125Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94643161
126Abolished electroretinogram (ERG) (HP:0000550)1.94439311
127Split foot (HP:0001839)1.93936623
128Cone-rod dystrophy (HP:0000548)1.93688240
129Abnormality of the phalanges of the 2nd finger (HP:0009541)1.93502351
130Myocardial infarction (HP:0001658)1.93372429
131Bifid scrotum (HP:0000048)1.93222221
132Decreased central vision (HP:0007663)1.93200817
133Aplasia/Hypoplasia of the tongue (HP:0010295)1.92261384
134Gout (HP:0001997)1.89796639
135Esophageal varix (HP:0002040)1.89762879
136Postaxial hand polydactyly (HP:0001162)1.89448456
137Symphalangism affecting the phalanges of the hand (HP:0009773)1.89133035
138Stenosis of the external auditory canal (HP:0000402)1.88773348
139Tetraplegia (HP:0002445)1.88161057
140Macular degeneration (HP:0000608)1.87716003
141Acute necrotizing encephalopathy (HP:0006965)1.87588632
142Nephrogenic diabetes insipidus (HP:0009806)1.86580882
143Scotoma (HP:0000575)1.86270877
144Short hallux (HP:0010109)1.86205215
145Attenuation of retinal blood vessels (HP:0007843)1.86108676
146Congenital hepatic fibrosis (HP:0002612)1.85933204
147Potter facies (HP:0002009)1.84576450
148Facial shape deformation (HP:0011334)1.84576450
149Abnormality of alanine metabolism (HP:0010916)1.83726473
150Hyperalaninemia (HP:0003348)1.83726473
151Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83726473
152Hyperbilirubinemia (HP:0002904)1.83124013
153Aplasia/Hypoplasia of the sternum (HP:0006714)1.82762338
154Amyloidosis (HP:0011034)1.81996786
155Acute encephalopathy (HP:0006846)1.80824902
156Fair hair (HP:0002286)1.80645530
157Abnormality of the labia minora (HP:0012880)1.79339122
158Esophageal atresia (HP:0002032)1.78981677
159Aplasia/Hypoplasia of the hallux (HP:0008362)1.78029041
160Abnormality of the renal collecting system (HP:0004742)1.77397864
161Thyroid-stimulating hormone excess (HP:0002925)1.76954124
162Tachypnea (HP:0002789)1.76520667
163Focal segmental glomerulosclerosis (HP:0000097)1.75210604
164Turricephaly (HP:0000262)1.74669819
165Retinal atrophy (HP:0001105)1.74119976
166Aplasia/hypoplasia of the uterus (HP:0008684)1.73268978
167Preaxial hand polydactyly (HP:0001177)1.73207290
168Abnormality of purine metabolism (HP:0004352)1.73150942
169Focal motor seizures (HP:0011153)1.73138397
170Aplasia/Hypoplasia of the uvula (HP:0010293)1.73016733
171Bony spicule pigmentary retinopathy (HP:0007737)1.72639943
172Central scotoma (HP:0000603)1.71600124
173Gastrointestinal atresia (HP:0002589)1.71584987
174Neurofibrillary tangles (HP:0002185)1.67369910
175Absent hair (HP:0002298)1.66673744
176Hemiplegia (HP:0002301)1.66509804
177Aplasia/Hypoplasia of the fibula (HP:0006492)1.66197970
178Renal cortical cysts (HP:0000803)1.65019193
179Adactyly (HP:0009776)1.62757111
180Pseudobulbar signs (HP:0002200)1.62512368
181Irritability (HP:0000737)1.57340772
182Metabolic acidosis (HP:0001942)1.56108410
183Glomerulosclerosis (HP:0000096)1.55561107

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK13.67899735
2NTRK23.44199985
3PNCK3.19123301
4EPHA43.06408269
5MAPK152.66703152
6SGK22.61953017
7WNK32.54343818
8BCKDK2.47586399
9LMTK22.43085121
10MARK12.37956126
11CASK2.32255460
12BMPR1B2.31988952
13LATS12.23574816
14ADRBK22.22055756
15ERBB42.18086581
16TNIK2.07516548
17NUAK12.01008102
18NTRK31.97591322
19SGK31.95718233
20MAP2K41.94545145
21SGK2231.91981249
22SGK4941.91981249
23STK391.89575372
24ZAK1.87975045
25MAP4K21.87885360
26WNK41.87773767
27STK38L1.87427353
28AKT31.85645313
29TAOK31.79579756
30PHKG21.79431700
31PHKG11.79431700
32WEE11.67594332
33STK381.65557244
34GRK11.55618123
35ACVR1B1.51975504
36LATS21.51748899
37FGFR21.45688386
38INSRR1.45491096
39TLK11.45327411
40PINK11.44181047
41FRK1.40477320
42DYRK21.34517426
43ERBB21.31621492
44MAP2K71.31327144
45VRK11.29960160
46FGFR41.29413238
47DAPK21.27893155
48PLK21.25621816
49DYRK1A1.24046369
50MAP3K41.22981684
51FER1.13622544
52NEK11.13391610
53TSSK61.12556607
54BRSK21.11489327
55TAF11.10892405
56PTK61.09259060
57MINK11.05639979
58PRKCG1.05469943
59EPHB21.04527136
60MUSK1.01821998
61TAOK21.00520747
62MAPK110.98272143
63PRKD30.97700056
64MAPK120.95771223
65RIPK10.94942047
66MAPK70.91767898
67CAMK1G0.91472895
68PIK3CA0.89829804
69MAPK130.89585677
70TIE10.86694517
71FGFR30.86408323
72CDK30.86010933
73MAP3K70.85162925
74PAK30.85117819
75MKNK20.84869268
76CAMKK20.84349468
77PRKAA20.84125629
78STK160.83803443
79PRKCZ0.83340450
80CDC70.80632028
81KSR10.78738823
82CAMKK10.78537753
83VRK20.77951384
84SGK10.76340524
85CSNK1G30.76158495
86OXSR10.75506721
87ICK0.74591542
88CSNK1G20.74389924
89TNK20.72287366
90PRKAA10.71360134
91CAMK2G0.69484906
92NEK60.69202159
93PLK30.66750449
94PRKCE0.66623979
95MAP3K20.66199703
96PBK0.64432675
97CDK50.64104327
98ERN10.64103685
99PLK40.62890292
100AKT20.62527532
101CAMK2A0.61708807
102TXK0.61654299
103MAP2K60.61478539
104PASK0.61040740
105CAMK1D0.60965377
106EPHA30.60789340
107PRKACG0.60603302
108ERBB30.57518863
109CSNK1A10.56970404
110PRKACA0.56517698
111PAK60.56177673
112CSNK1A1L0.55314942
113PDGFRA0.54236687
114PLK10.53888375
115CSNK1G10.53297291
116MAPKAPK30.52284443
117TRIB30.50404136
118RPS6KA30.50159083
119IRAK30.49240240
120BMX0.49208076
121DYRK1B0.48179841
122CAMK10.47798280
123EPHA20.47198768
124MAPKAPK50.46583166
125MAP3K90.46421957
126DYRK30.46281098
127FGFR10.46057404
128AURKA0.45888972
129PRKG10.44951211
130CDK80.44881437
131ROCK10.44856191
132SIK20.44056411
133BCR0.43885110
134CDK60.43455344
135ADRBK10.43242158
136CAMK40.42799975
137CSNK1D0.42681707
138PKN10.42609495
139PRKCI0.41935820
140TYRO30.41478534
141RPS6KA50.41300149
142PRKCA0.41124369
143MST1R0.40987913
144STK110.40534017
145MST40.40037047
146PRKCH0.39903638
147TGFBR10.38202265
148GSK3A0.38147237
149TRIM280.36723789
150IGF1R0.36520624

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.24068384
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.75308960
3Arginine biosynthesis_Homo sapiens_hsa002203.13123069
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.76671085
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71081505
6Fatty acid degradation_Homo sapiens_hsa000712.33203614
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.28801993
8Linoleic acid metabolism_Homo sapiens_hsa005912.21110503
9Complement and coagulation cascades_Homo sapiens_hsa046102.18069708
10Tryptophan metabolism_Homo sapiens_hsa003802.08604016
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02693228
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99192743
13Fatty acid metabolism_Homo sapiens_hsa012121.95525865
14Oxidative phosphorylation_Homo sapiens_hsa001901.92864212
15Butanoate metabolism_Homo sapiens_hsa006501.91650523
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.88071031
17Bile secretion_Homo sapiens_hsa049761.86902585
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.86879869
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.86459190
20PPAR signaling pathway_Homo sapiens_hsa033201.86417558
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86135626
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80849946
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.80633699
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.74351801
25Chemical carcinogenesis_Homo sapiens_hsa052041.74025292
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72932659
27Retinol metabolism_Homo sapiens_hsa008301.70528980
28Peroxisome_Homo sapiens_hsa041461.69801599
29Fatty acid biosynthesis_Homo sapiens_hsa000611.69370495
30Caffeine metabolism_Homo sapiens_hsa002321.60214462
31Phototransduction_Homo sapiens_hsa047441.57508582
32Parkinsons disease_Homo sapiens_hsa050121.55278382
33Protein export_Homo sapiens_hsa030601.48455975
34Ribosome_Homo sapiens_hsa030101.48080630
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45737388
36Propanoate metabolism_Homo sapiens_hsa006401.41862386
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38737298
38Histidine metabolism_Homo sapiens_hsa003401.37755980
39Fanconi anemia pathway_Homo sapiens_hsa034601.34253450
40RNA polymerase_Homo sapiens_hsa030201.33837487
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.29697900
42beta-Alanine metabolism_Homo sapiens_hsa004101.26175112
43Cardiac muscle contraction_Homo sapiens_hsa042601.23044531
44Basal transcription factors_Homo sapiens_hsa030221.18171919
45Ether lipid metabolism_Homo sapiens_hsa005651.17934677
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17665404
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16214411
48Homologous recombination_Homo sapiens_hsa034401.15337861
49Steroid biosynthesis_Homo sapiens_hsa001001.15271607
50Starch and sucrose metabolism_Homo sapiens_hsa005001.15255947
51ABC transporters_Homo sapiens_hsa020101.15024884
52Huntingtons disease_Homo sapiens_hsa050161.13490998
53Fat digestion and absorption_Homo sapiens_hsa049751.12407552
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09893777
55RNA degradation_Homo sapiens_hsa030181.09383704
56Olfactory transduction_Homo sapiens_hsa047401.08972087
57Sulfur metabolism_Homo sapiens_hsa009201.06026732
58Alzheimers disease_Homo sapiens_hsa050101.05544008
59Vitamin digestion and absorption_Homo sapiens_hsa049771.03862501
60Selenocompound metabolism_Homo sapiens_hsa004501.02629355
61Phenylalanine metabolism_Homo sapiens_hsa003600.98359626
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95031542
63Nicotine addiction_Homo sapiens_hsa050330.94789035
64Biosynthesis of amino acids_Homo sapiens_hsa012300.93856296
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91796338
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91715725
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.90670120
68Hedgehog signaling pathway_Homo sapiens_hsa043400.90034037
69Tyrosine metabolism_Homo sapiens_hsa003500.89574769
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89504573
71Fatty acid elongation_Homo sapiens_hsa000620.89486329
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.89327244
73Serotonergic synapse_Homo sapiens_hsa047260.88273282
74Staphylococcus aureus infection_Homo sapiens_hsa051500.87713401
75Arachidonic acid metabolism_Homo sapiens_hsa005900.84537126
76Arginine and proline metabolism_Homo sapiens_hsa003300.84514931
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81633608
78Glycerolipid metabolism_Homo sapiens_hsa005610.81202082
79Lysine degradation_Homo sapiens_hsa003100.80477080
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79524472
81Cocaine addiction_Homo sapiens_hsa050300.75447605
82GABAergic synapse_Homo sapiens_hsa047270.69762411
83Pyruvate metabolism_Homo sapiens_hsa006200.67084914
84Circadian rhythm_Homo sapiens_hsa047100.66765706
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65194291
86Vitamin B6 metabolism_Homo sapiens_hsa007500.64820539
87Amphetamine addiction_Homo sapiens_hsa050310.62203180
88Glutamatergic synapse_Homo sapiens_hsa047240.61193980
89Dopaminergic synapse_Homo sapiens_hsa047280.58213848
90Ovarian steroidogenesis_Homo sapiens_hsa049130.56385015
91Carbon metabolism_Homo sapiens_hsa012000.55793742
92Nucleotide excision repair_Homo sapiens_hsa034200.54099868
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.50984524
94Dorso-ventral axis formation_Homo sapiens_hsa043200.50615871
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47628519
96Salivary secretion_Homo sapiens_hsa049700.45889851
97Hippo signaling pathway_Homo sapiens_hsa043900.44846353
98Basal cell carcinoma_Homo sapiens_hsa052170.44389019
99Insulin secretion_Homo sapiens_hsa049110.43701560
100Purine metabolism_Homo sapiens_hsa002300.43307760
101Circadian entrainment_Homo sapiens_hsa047130.42603228
102Prion diseases_Homo sapiens_hsa050200.42057639
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41166110
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40153464
105Folate biosynthesis_Homo sapiens_hsa007900.39831095
106Glutathione metabolism_Homo sapiens_hsa004800.38153375
107Mineral absorption_Homo sapiens_hsa049780.37693401
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33239752
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.30632410
110Glucagon signaling pathway_Homo sapiens_hsa049220.28547268
111Pancreatic secretion_Homo sapiens_hsa049720.27923913
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.27752548
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27367341
114Gastric acid secretion_Homo sapiens_hsa049710.26991720
115Renin secretion_Homo sapiens_hsa049240.26224072
116Fructose and mannose metabolism_Homo sapiens_hsa000510.25230185
117African trypanosomiasis_Homo sapiens_hsa051430.24274026
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24132685
119Taste transduction_Homo sapiens_hsa047420.23584896
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23266629
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23156855
122Sulfur relay system_Homo sapiens_hsa041220.23060899
123Insulin resistance_Homo sapiens_hsa049310.22981109
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22931580
125One carbon pool by folate_Homo sapiens_hsa006700.22641017
126Metabolic pathways_Homo sapiens_hsa011000.21849386
127Pentose phosphate pathway_Homo sapiens_hsa000300.21187746
128Morphine addiction_Homo sapiens_hsa050320.21098971
129Calcium signaling pathway_Homo sapiens_hsa040200.18935941
130Melanogenesis_Homo sapiens_hsa049160.18620913
131Axon guidance_Homo sapiens_hsa043600.18269978
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.17043568
133cAMP signaling pathway_Homo sapiens_hsa040240.15470393

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