ARHGEF28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ectoderm development (GO:0007398)7.60002130
2regulation of DNA methylation (GO:0044030)6.77519784
3central nervous system myelination (GO:0022010)5.87410776
4axon ensheathment in central nervous system (GO:0032291)5.87410776
5negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)5.80382459
6glyoxylate metabolic process (GO:0046487)5.74275770
7response to hepatocyte growth factor (GO:0035728)5.38218604
8cellular response to hepatocyte growth factor stimulus (GO:0035729)5.38218604
9hemidesmosome assembly (GO:0031581)5.17957515
10negative regulation of keratinocyte proliferation (GO:0010839)5.13627831
11female gonad development (GO:0008585)4.80448249
12androgen biosynthetic process (GO:0006702)4.53111614
13stress granule assembly (GO:0034063)4.29425093
14cell adhesion mediated by integrin (GO:0033627)4.27904121
15negative regulation of protein tyrosine kinase activity (GO:0061099)4.27704074
16regulation of G0 to G1 transition (GO:0070316)4.17802340
17thyroid hormone generation (GO:0006590)4.12040665
18desmosome organization (GO:0002934)4.02745128
19phospholipid translocation (GO:0045332)4.00118591
20lipid translocation (GO:0034204)4.00118591
21myelination (GO:0042552)4.00045553
22ensheathment of neurons (GO:0007272)3.99574859
23axon ensheathment (GO:0008366)3.99574859
24negative regulation of fibrinolysis (GO:0051918)3.91068983
25peptidyl-lysine dimethylation (GO:0018027)3.90497665
26positive regulation of keratinocyte differentiation (GO:0045618)3.74263492
27negative regulation of glycoprotein biosynthetic process (GO:0010561)3.61987910
28embryonic heart tube development (GO:0035050)3.56364272
29vitamin transmembrane transport (GO:0035461)3.46854694
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.46179874
31negative regulation of neurotransmitter transport (GO:0051589)3.44952690
32chaperone-mediated protein transport (GO:0072321)3.43958368
33thyroid hormone metabolic process (GO:0042403)3.43424271
34myelin maintenance (GO:0043217)3.42780706
35cranial suture morphogenesis (GO:0060363)3.42558532
36mammary gland epithelial cell proliferation (GO:0033598)3.42435397
37regulation of protein glycosylation (GO:0060049)3.39456875
38neuron cell-cell adhesion (GO:0007158)3.39194144
39apical protein localization (GO:0045176)3.34959163
40long-chain fatty acid biosynthetic process (GO:0042759)3.34542811
41fatty acid elongation (GO:0030497)3.33211564
42ventricular trabecula myocardium morphogenesis (GO:0003222)3.31133649
43regulation of fibrinolysis (GO:0051917)3.30125183
44centrosome duplication (GO:0051298)3.28192560
45regulation of keratinocyte proliferation (GO:0010837)3.27108277
46negative regulation of neurotransmitter secretion (GO:0046929)3.20506612
47intestinal cholesterol absorption (GO:0030299)3.17802995
48asymmetric protein localization (GO:0008105)3.16970948
49negative regulation of receptor activity (GO:2000272)3.16309615
50neuron recognition (GO:0008038)3.13818461
51axonal fasciculation (GO:0007413)3.13544085
52positive regulation of epidermal cell differentiation (GO:0045606)3.13443653
53mesodermal cell differentiation (GO:0048333)3.12421321
54peptidyl-tyrosine autophosphorylation (GO:0038083)3.11143686
55COPII vesicle coating (GO:0048208)3.08104047
56photoreceptor cell differentiation (GO:0046530)3.06888327
57eye photoreceptor cell differentiation (GO:0001754)3.06888327
58presynaptic membrane assembly (GO:0097105)3.06797892
59actin filament depolymerization (GO:0030042)3.05776499
60craniofacial suture morphogenesis (GO:0097094)3.04444121
61regulation of telomere maintenance via telomerase (GO:0032210)3.03875612
62cell-substrate junction assembly (GO:0007044)3.00010180
63retina vasculature morphogenesis in camera-type eye (GO:0061299)2.99733971
64cellular response to epinephrine stimulus (GO:0071872)2.99363946
65presynaptic membrane organization (GO:0097090)2.96356336
66positive regulation of fatty acid beta-oxidation (GO:0032000)2.95550775
67branching involved in mammary gland duct morphogenesis (GO:0060444)2.92321613
68lymphangiogenesis (GO:0001946)2.91432398
69negative regulation of glycoprotein metabolic process (GO:1903019)2.89803779
70phenol-containing compound catabolic process (GO:0019336)2.89257567
71negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.89082148
72transmission of nerve impulse (GO:0019226)2.88749126
73glucocorticoid biosynthetic process (GO:0006704)2.88566361
74endocardial cushion development (GO:0003197)2.87475974
75hypotonic response (GO:0006971)2.87008180
76positive regulation of hormone biosynthetic process (GO:0046886)2.84129292
77Golgi transport vesicle coating (GO:0048200)2.83936606
78COPI coating of Golgi vesicle (GO:0048205)2.83936606
79galactose metabolic process (GO:0006012)2.82155053
80positive regulation of protein import into nucleus, translocation (GO:0033160)2.81278320
81substrate-dependent cell migration (GO:0006929)2.81204502
82dendritic spine morphogenesis (GO:0060997)2.80865068
83glomerular epithelial cell development (GO:0072310)2.80001324
84skin morphogenesis (GO:0043589)2.78720236
85dopamine biosynthetic process (GO:0042416)2.77555423
86neuronal action potential propagation (GO:0019227)2.77110607
87oligodendrocyte differentiation (GO:0048709)2.76459815
88regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.76105078
89regulation of plasminogen activation (GO:0010755)2.74092126
90maintenance of protein location in nucleus (GO:0051457)2.72804775
91hepatocyte differentiation (GO:0070365)2.71690708
92regulation of fatty acid beta-oxidation (GO:0031998)2.71251726
93neuron remodeling (GO:0016322)2.71193603
94chondrocyte proliferation (GO:0035988)2.69990093
95regulation of transforming growth factor beta2 production (GO:0032909)2.69686071
96positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.69086879
97negative regulation of fatty acid biosynthetic process (GO:0045717)2.68576683
98virion attachment to host cell (GO:0019062)2.68422760
99adhesion of symbiont to host cell (GO:0044650)2.68422760
100cellular response to monoamine stimulus (GO:0071868)2.68165842
101cellular response to catecholamine stimulus (GO:0071870)2.68165842
102male meiosis (GO:0007140)2.67489866
103peripheral nervous system axon ensheathment (GO:0032292)2.67478782
104myelination in peripheral nervous system (GO:0022011)2.67478782
105mating behavior (GO:0007617)2.67425661
106regulation of keratinocyte differentiation (GO:0045616)2.65945323
107dendritic spine organization (GO:0097061)2.64784020
108regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.64316337
109response to epinephrine (GO:0071871)2.63767732
110nerve growth factor signaling pathway (GO:0038180)2.61959279
111negative regulation of protein localization to cell surface (GO:2000009)2.60930242
112regulation of steroid hormone biosynthetic process (GO:0090030)2.60831801
113regulation of complement activation (GO:0030449)2.60329540
114endodermal cell differentiation (GO:0035987)2.59019222
115neuronal ion channel clustering (GO:0045161)2.57554417
116negative regulation of axon extension (GO:0030517)2.57451670
117negative regulation of fatty acid transport (GO:2000192)2.57408412
118regulation of protein activation cascade (GO:2000257)2.56332881
119neurotransmitter catabolic process (GO:0042135)2.56230740
120peptidyl-glutamic acid carboxylation (GO:0017187)2.56003996
121protein carboxylation (GO:0018214)2.56003996
122pyrimidine-containing compound transmembrane transport (GO:0072531)2.55862920
123endothelial cell morphogenesis (GO:0001886)2.55632462
124endocardial cushion morphogenesis (GO:0003203)2.54526162
125cytoskeletal anchoring at plasma membrane (GO:0007016)2.54407155
126androgen metabolic process (GO:0008209)2.53610176
127drug transmembrane transport (GO:0006855)2.52347249
128membrane assembly (GO:0071709)2.51616419
129glomerular visceral epithelial cell development (GO:0072015)2.51596842
130wound healing, spreading of epidermal cells (GO:0035313)2.50236839
131cell migration involved in heart development (GO:0060973)2.49549582
132establishment of mitochondrion localization (GO:0051654)2.48347734
133inner mitochondrial membrane organization (GO:0007007)2.47680411
134limb bud formation (GO:0060174)2.47669670
135response to monoamine (GO:0071867)2.47089366
136response to catecholamine (GO:0071869)2.47089366
137apoptotic cell clearance (GO:0043277)2.46767789
138negative regulation of axonogenesis (GO:0050771)2.46684448
139vocalization behavior (GO:0071625)2.46621302
140positive regulation of hormone metabolic process (GO:0032352)2.45686491
141calcium-mediated signaling using intracellular calcium source (GO:0035584)2.44186048
142negative regulation of chondrocyte differentiation (GO:0032331)2.42696299
143regulation of vesicle fusion (GO:0031338)2.40626699
144substantia nigra development (GO:0021762)2.40374027
145positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.39617262
146regulation of short-term neuronal synaptic plasticity (GO:0048172)2.39529976
147dendrite morphogenesis (GO:0048813)2.39281735
148ionotropic glutamate receptor signaling pathway (GO:0035235)2.39013262
149regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.37783634
150ERK1 and ERK2 cascade (GO:0070371)2.37632205
151bundle of His cell to Purkinje myocyte communication (GO:0086069)2.36152077
152hormone biosynthetic process (GO:0042446)2.35018639
153excretion (GO:0007588)2.34102848
154response to redox state (GO:0051775)2.33745319
155sensory perception of smell (GO:0007608)2.33667238
156calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.31957977
157fibrinolysis (GO:0042730)2.30827506
158magnesium ion transport (GO:0015693)2.29935961
159positive regulation of osteoblast proliferation (GO:0033690)2.29687626
160regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.29384415
161regulation of sister chromatid cohesion (GO:0007063)2.28575072
162regulation of membrane lipid distribution (GO:0097035)2.28395598
163negative regulation of axon extension involved in axon guidance (GO:0048843)2.27627540
164synaptic vesicle exocytosis (GO:0016079)2.27374005
165synaptic transmission, glutamatergic (GO:0035249)2.27130017
166regulation of axon extension involved in axon guidance (GO:0048841)2.26813662
167ephrin receptor signaling pathway (GO:0048013)2.25807040
168glutamate secretion (GO:0014047)2.25704115
169glutamate receptor signaling pathway (GO:0007215)2.24949025
170glycine transport (GO:0015816)2.24541920
171positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.24404003
172L-amino acid import (GO:0043092)2.24090357
173catechol-containing compound biosynthetic process (GO:0009713)2.22767002
174catecholamine biosynthetic process (GO:0042423)2.22767002
175locomotory exploration behavior (GO:0035641)2.22350651
176synaptic vesicle maturation (GO:0016188)2.21700892
177protein localization to endosome (GO:0036010)2.21155407
178astrocyte development (GO:0014002)2.20279603
179cellular response to nerve growth factor stimulus (GO:1990090)2.19908833
180response to nerve growth factor (GO:1990089)2.19908833
181regulation of neuronal synaptic plasticity (GO:0048168)2.19482513
182detection of calcium ion (GO:0005513)2.18932516
183long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.18512617
184regulation of dendritic spine morphogenesis (GO:0061001)2.18169225
185cerebral cortex radially oriented cell migration (GO:0021799)2.17268803
186positive regulation of oligodendrocyte differentiation (GO:0048714)2.17218204
187regulation of synaptic vesicle exocytosis (GO:2000300)2.16843546
188positive regulation of potassium ion transport (GO:0043268)2.16652033
189protein localization to synapse (GO:0035418)2.14264060
190regulation of collateral sprouting (GO:0048670)2.13911441
191positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.13693900
192neuron-neuron synaptic transmission (GO:0007270)2.13452018
193adult walking behavior (GO:0007628)2.12964763
194regulation of axon guidance (GO:1902667)2.12600994
195gamma-aminobutyric acid signaling pathway (GO:0007214)2.11223867
196positive regulation of neurological system process (GO:0031646)2.10524733
197peripheral nervous system development (GO:0007422)2.10305667
198cyclic nucleotide catabolic process (GO:0009214)2.09444338
199regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.06745093

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.12474249
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.33610705
3EZH2_22144423_ChIP-Seq_EOC_Human4.20730449
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.35043461
5GBX2_23144817_ChIP-Seq_PC3_Human3.14682538
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.94730384
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.64449246
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63678342
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.46367114
10PPAR_26484153_Chip-Seq_NCI-H1993_Human2.45689337
11CJUN_26792858_Chip-Seq_BT549_Human2.44911829
12GATA2_21666600_ChIP-Seq_HMVEC_Human2.44037488
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42120232
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36226845
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36226845
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30473199
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29646881
18ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.27326860
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.23975994
20SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.22484147
21SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.22484147
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22242365
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19740226
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17347458
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.16392776
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.12841813
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08814005
28TRIM28_21343339_ChIP-Seq_HEK293_Human2.08793997
29HIF1A_21447827_ChIP-Seq_MCF-7_Human2.05227659
30DROSHA_22980978_ChIP-Seq_HELA_Human1.93157860
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.88449797
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.85782652
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84521755
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84509914
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.82596074
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77994475
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69309545
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.68429901
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.66514042
40TAF15_26573619_Chip-Seq_HEK293_Human1.66010276
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65744255
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.64654371
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.63963922
44IGF1R_20145208_ChIP-Seq_DFB_Human1.63849252
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.63663952
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.63486291
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63434967
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63031810
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.62788011
50FOXA2_19822575_ChIP-Seq_HepG2_Human1.62317507
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59801145
52AR_21572438_ChIP-Seq_LNCaP_Human1.57126583
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55590745
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55589613
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52777145
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.51206821
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51100937
58* BRD4_25478319_ChIP-Seq_HGPS_Human1.49880238
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47610932
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47443485
61LXR_22158963_ChIP-Seq_LIVER_Mouse1.47017497
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45705182
63JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45656750
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45164148
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42568752
66TBX20_22328084_ChIP-Seq_HEART_Mouse1.42049526
67TBX20_22080862_ChIP-Seq_HEART_Mouse1.42049526
68AHR_22903824_ChIP-Seq_MCF-7_Human1.40977910
69JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40804147
70TP63_23658742_ChIP-Seq_EP156T_Human1.40600364
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38881566
72SMAD4_21799915_ChIP-Seq_A2780_Human1.38796524
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.38381822
74GATA4_25053715_ChIP-Seq_YYC3_Human1.36263403
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35403204
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34626801
77P300_19829295_ChIP-Seq_ESCs_Human1.34618373
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33383879
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32702878
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32338082
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31578724
82CDX2_20551321_ChIP-Seq_CACO-2_Human1.30567470
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.28803467
84VDR_22108803_ChIP-Seq_LS180_Human1.28525979
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.27718696
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.27422080
87REST_21632747_ChIP-Seq_MESCs_Mouse1.27103659
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26887512
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25879589
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25879589
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25875567
92* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25811260
93RARB_27405468_Chip-Seq_BRAIN_Mouse1.23029142
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22530856
95TP53_18474530_ChIP-ChIP_U2OS_Human1.21250479
96TP53_22127205_ChIP-Seq_IMR90_Human1.20402724
97ER_23166858_ChIP-Seq_MCF-7_Human1.19562747
98POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17104543
99ESR2_21235772_ChIP-Seq_MCF-7_Human1.16920413
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16320897
101CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15565321
102FUS_26573619_Chip-Seq_HEK293_Human1.13664072
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13157480
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12766598
105TP53_16413492_ChIP-PET_HCT116_Human1.12689611
106STAT3_23295773_ChIP-Seq_U87_Human1.12180161
107CLOCK_20551151_ChIP-Seq_293T_Human1.11736192
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10714835
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10574011
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08555050
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08313921
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08045589
113GATA3_24758297_ChIP-Seq_MCF-7_Human1.07357614
114RING1B_27294783_Chip-Seq_NPCs_Mouse1.07215040
115GATA6_25053715_ChIP-Seq_YYC3_Human1.07032222
116ERG_21242973_ChIP-ChIP_JURKAT_Human1.06743769
117TCF4_18268006_ChIP-ChIP_LS174T_Human1.06255326
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05726735
119RING1B_27294783_Chip-Seq_ESCs_Mouse1.05701576
120ESR1_20079471_ChIP-ChIP_T-47D_Human1.05183463
121ZNF274_21170338_ChIP-Seq_K562_Hela1.04554092
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03996621
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03623936
124SOX2_21211035_ChIP-Seq_LN229_Gbm1.03436863
125PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02704743
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01837397
127PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00172598
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99463562
129FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98589261
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.98340485
131PRDM14_20953172_ChIP-Seq_ESCs_Human0.98081501
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.97835971
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97817437
134AR_25329375_ChIP-Seq_VCAP_Human0.97668650
135NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97424920
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97012573
137TCF4_23295773_ChIP-Seq_U87_Human0.97002260
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96928977
139YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95785085
140RUNX2_22187159_ChIP-Seq_PCA_Human0.95715590
141REST_18959480_ChIP-ChIP_MESCs_Mouse0.95589590
142P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94806828
143RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94313167
144ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94031250
145ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.92662408
146EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92537348
147IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90350473
148GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89932167
149WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89876568
150LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89496611
151CBP_21632823_ChIP-Seq_H3396_Human0.89220629
152RNF2_27304074_Chip-Seq_NSC_Mouse0.88659269
153PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88522889
154ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87782827
155P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87691524
156SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87620985
157MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87515002
158BCAT_22108803_ChIP-Seq_LS180_Human0.87380250
159SOX2_20726797_ChIP-Seq_SW620_Human0.87205790
160FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86794409
161CDX2_22108803_ChIP-Seq_LS180_Human0.86524455
162FOXA1_25552417_ChIP-Seq_VCAP_Human0.86265935
163KLF5_25053715_ChIP-Seq_YYC3_Human0.85862586
164IRF1_19129219_ChIP-ChIP_H3396_Human0.85827392
165HNF4A_19822575_ChIP-Seq_HepG2_Human0.83559594

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence5.05841896
2MP0010368_abnormal_lymphatic_system4.30222764
3MP0004270_analgesia3.60253406
4MP0003880_abnormal_central_pattern3.49732794
5MP0004859_abnormal_synaptic_plasticity3.31902670
6MP0003566_abnormal_cell_adhesion2.95700716
7MP0008875_abnormal_xenobiotic_pharmacok2.86519057
8MP0000920_abnormal_myelination2.67435989
9MP0003786_premature_aging2.47453758
10MP0003635_abnormal_synaptic_transmissio2.36106062
11MP0004264_abnormal_extraembryonic_tissu2.34293289
12MP0005360_urolithiasis2.23470361
13MP0005275_abnormal_skin_tensile2.18467312
14MP0003941_abnormal_skin_development2.18444355
15MP0002272_abnormal_nervous_system2.17106118
16MP0002734_abnormal_mechanical_nocicepti2.16609816
17MP0001661_extended_life_span2.15123807
18MP0002822_catalepsy2.12515492
19MP0009745_abnormal_behavioral_response2.12001786
20MP0001849_ear_inflammation2.08222439
21MP0000778_abnormal_nervous_system2.07474353
22MP0002064_seizures1.99601971
23MP0003329_amyloid_beta_deposits1.96848544
24MP0001905_abnormal_dopamine_level1.96693306
25MP0005023_abnormal_wound_healing1.94163712
26MP0004885_abnormal_endolymph1.89793894
27MP0005257_abnormal_intraocular_pressure1.89484455
28MP0009780_abnormal_chondrocyte_physiolo1.88726030
29MP0001486_abnormal_startle_reflex1.88405123
30MP0001879_abnormal_lymphatic_vessel1.85960017
31MP0005171_absent_coat_pigmentation1.85304766
32MP0003868_abnormal_feces_composition1.84023245
33MP0005623_abnormal_meninges_morphology1.80357531
34MP0002063_abnormal_learning/memory/cond1.80232165
35MP0001666_abnormal_nutrient_absorption1.80056388
36MP0001485_abnormal_pinna_reflex1.79781026
37MP0005085_abnormal_gallbladder_physiolo1.76959554
38MP0004272_abnormal_basement_membrane1.75172780
39MP0010386_abnormal_urinary_bladder1.73981704
40MP0001440_abnormal_grooming_behavior1.71547518
41MP0003705_abnormal_hypodermis_morpholog1.71164494
42MP0004742_abnormal_vestibular_system1.68474783
43MP0004043_abnormal_pH_regulation1.63168186
44MP0000566_synostosis1.62406640
45MP0002572_abnormal_emotion/affect_behav1.61097383
46MP0010352_gastrointestinal_tract_polyps1.57634956
47MP0001529_abnormal_vocalization1.57061581
48MP0001501_abnormal_sleep_pattern1.56459527
49MP0003950_abnormal_plasma_membrane1.56208718
50MP0003091_abnormal_cell_migration1.52737617
51MP0002733_abnormal_thermal_nociception1.47762774
52MP0002139_abnormal_hepatobiliary_system1.43233292
53MP0000013_abnormal_adipose_tissue1.42910869
54MP0001968_abnormal_touch/_nociception1.41775449
55MP0003634_abnormal_glial_cell1.41462930
56MP0001984_abnormal_olfaction1.41093580
57MP0000462_abnormal_digestive_system1.40924714
58MP0002735_abnormal_chemical_nociception1.40778966
59MP0001970_abnormal_pain_threshold1.40060378
60MP0004858_abnormal_nervous_system1.39975282
61MP0003690_abnormal_glial_cell1.37163072
62MP0003252_abnormal_bile_duct1.37000324
63MP0003279_aneurysm1.35702778
64MP0003195_calcinosis1.35443967
65MP0005645_abnormal_hypothalamus_physiol1.33322358
66MP0008438_abnormal_cutaneous_collagen1.32605904
67MP0002060_abnormal_skin_morphology1.29404319
68MP0002697_abnormal_eye_size1.29392995
69MP0003191_abnormal_cellular_cholesterol1.29074731
70MP0001299_abnormal_eye_distance/1.28538926
71MP0000767_abnormal_smooth_muscle1.28264363
72MP0008004_abnormal_stomach_pH1.27904241
73MP0005409_darkened_coat_color1.26627943
74MP0002882_abnormal_neuron_morphology1.23808390
75MP0002896_abnormal_bone_mineralization1.23615165
76MP0005365_abnormal_bile_salt1.22332713
77MP0002295_abnormal_pulmonary_circulatio1.20403107
78MP0005423_abnormal_somatic_nervous1.19943904
79MP0002184_abnormal_innervation1.18900279
80MP0002067_abnormal_sensory_capabilities1.18482625
81MP0001177_atelectasis1.17910434
82MP0009046_muscle_twitch1.17784691
83MP0003943_abnormal_hepatobiliary_system1.17187524
84MP0006054_spinal_hemorrhage1.17163377
85MP0000955_abnormal_spinal_cord1.15844553
86MP0003136_yellow_coat_color1.15397005
87MP0006276_abnormal_autonomic_nervous1.15035480
88MP0002877_abnormal_melanocyte_morpholog1.14949592
89MP0002837_dystrophic_cardiac_calcinosis1.14705041
90MP0002168_other_aberrant_phenotype1.13011829
91MP0001958_emphysema1.12887058
92MP0000733_abnormal_muscle_development1.12138177
93MP0010678_abnormal_skin_adnexa1.12064188
94MP0000762_abnormal_tongue_morphology1.11915728
95MP0002736_abnormal_nociception_after1.08324262
96MP0004924_abnormal_behavior1.06703997
97MP0005386_behavior/neurological_phenoty1.06703997
98MP0002127_abnormal_cardiovascular_syste1.06656486
99MP0010329_abnormal_lipoprotein_level1.06264627
100MP0001664_abnormal_digestion1.06182148
101MP0008569_lethality_at_weaning1.05677406
102MP0002557_abnormal_social/conspecific_i1.05103038
103MP0002066_abnormal_motor_capabilities/c1.03167452
104MP0003633_abnormal_nervous_system1.02521093
105MP0001963_abnormal_hearing_physiology1.02504124
106MP0002796_impaired_skin_barrier1.01948764
107MP0002229_neurodegeneration1.00869471
108MP0003631_nervous_system_phenotype1.00543487
109MP0004142_abnormal_muscle_tone0.99412688
110MP0003632_abnormal_nervous_system0.99385385
111MP0001765_abnormal_ion_homeostasis0.98985403
112MP0004019_abnormal_vitamin_homeostasis0.98938569
113MP0009384_cardiac_valve_regurgitation0.98648019
114MP0002752_abnormal_somatic_nervous0.97711659
115MP0004233_abnormal_muscle_weight0.96626804
116MP0000003_abnormal_adipose_tissue0.95553869
117MP0000579_abnormal_nail_morphology0.95516505
118MP0009053_abnormal_anal_canal0.94810751
119MP0002653_abnormal_ependyma_morphology0.93121106
120MP0005646_abnormal_pituitary_gland0.92966817
121MP0003045_fibrosis0.92084483
122MP0001944_abnormal_pancreas_morphology0.91460687
123MP0009379_abnormal_foot_pigmentation0.90997740
124MP0005197_abnormal_uvea_morphology0.90317547
125MP0001188_hyperpigmentation0.89804536
126MP0000467_abnormal_esophagus_morphology0.89763001
127MP0001346_abnormal_lacrimal_gland0.88953670
128MP0005508_abnormal_skeleton_morphology0.88136311
129MP0004145_abnormal_muscle_electrophysio0.87885925
130MP0000026_abnormal_inner_ear0.86801323
131MP0000538_abnormal_urinary_bladder0.86346618
132MP0000627_abnormal_mammary_gland0.85215327
133MP0000537_abnormal_urethra_morphology0.84974935
134MP0005164_abnormal_response_to0.84935749
135MP0001502_abnormal_circadian_rhythm0.84528991
136MP0000383_abnormal_hair_follicle0.83342874
137MP0005595_abnormal_vascular_smooth0.83002796
138MP0003283_abnormal_digestive_organ0.82804446
139MP0004134_abnormal_chest_morphology0.82443715
140MP0005083_abnormal_biliary_tract0.82402008
141MP0002128_abnormal_blood_circulation0.82140556
142MP0001216_abnormal_epidermal_layer0.82020483
143MP0003453_abnormal_keratinocyte_physiol0.81179054
144MP0010030_abnormal_orbit_morphology0.79796289
145MP0002152_abnormal_brain_morphology0.79731391
146MP0002876_abnormal_thyroid_physiology0.79053598
147MP0005330_cardiomyopathy0.78605677
148MP0002234_abnormal_pharynx_morphology0.74772050
149MP0000747_muscle_weakness0.73454937
150MP0009840_abnormal_foam_cell0.73262798
151MP0004811_abnormal_neuron_physiology0.73065413
152MP0004782_abnormal_surfactant_physiolog0.71756512
153MP0000639_abnormal_adrenal_gland0.71459199
154MP0000534_abnormal_ureter_morphology0.71451600
155MP0002133_abnormal_respiratory_system0.71147313
156MP0005388_respiratory_system_phenotype0.71147313
157MP0010234_abnormal_vibrissa_follicle0.71119553
158MP0003937_abnormal_limbs/digits/tail_de0.70900172
159MP0002909_abnormal_adrenal_gland0.70803371
160MP0003936_abnormal_reproductive_system0.70709129
161MP0000631_abnormal_neuroendocrine_gland0.70700828
162MP0003828_pulmonary_edema0.70484080
163MP0002138_abnormal_hepatobiliary_system0.68729295
164MP0001614_abnormal_blood_vessel0.68220073
165MP0008775_abnormal_heart_ventricle0.67623433
166MP0000249_abnormal_blood_vessel0.66772479
167MP0002132_abnormal_respiratory_system0.66416103
168MP0003699_abnormal_female_reproductive0.65269036
169MP0005501_abnormal_skin_physiology0.62655347
170MP0005395_other_phenotype0.62564855
171MP0005165_increased_susceptibility_to0.61968126
172MP0009250_abnormal_appendicular_skeleto0.61628081
173MP0001881_abnormal_mammary_gland0.61051255
174MP0002925_abnormal_cardiovascular_devel0.60969513
175MP0005167_abnormal_blood-brain_barrier0.60062159

Predicted human phenotypes

RankGene SetZ-score
1Duplicated collecting system (HP:0000081)7.82727938
2Chromosomal breakage induced by crosslinking agents (HP:0003221)7.02003880
3Abnormality of the renal collecting system (HP:0004742)6.81914539
4Chromsome breakage (HP:0040012)6.29227855
5Abnormality of pyrimidine metabolism (HP:0004353)5.78272064
6Ureteral duplication (HP:0000073)5.57563347
7Abnormality of DNA repair (HP:0003254)4.88151646
8Neurofibrillary tangles (HP:0002185)4.77688198
9Reticulocytopenia (HP:0001896)4.50895649
10Oral leukoplakia (HP:0002745)4.50710402
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.23426629
12Degeneration of the lateral corticospinal tracts (HP:0002314)4.23426629
13Cerebral inclusion bodies (HP:0100314)4.06361710
14Increased circulating renin level (HP:0000848)3.99923418
15Duplication of thumb phalanx (HP:0009942)3.93609312
16Myokymia (HP:0002411)3.79741825
17Metabolic alkalosis (HP:0200114)3.60906932
18Hypoplasia of the capital femoral epiphysis (HP:0003090)3.48469485
19Aplastic anemia (HP:0001915)3.42604450
20Protrusio acetabuli (HP:0003179)3.35376219
21Ectopic kidney (HP:0000086)3.27295235
22Abnormality of the corticospinal tract (HP:0002492)3.26322630
23Sensory axonal neuropathy (HP:0003390)3.25989096
24Hypokalemic alkalosis (HP:0001949)3.25610795
25Abnormality of carpal bone ossification (HP:0006257)3.17372232
26Focal motor seizures (HP:0011153)3.12928245
27Supranuclear gaze palsy (HP:0000605)3.10888624
28Retinal dysplasia (HP:0007973)3.09147516
29Hyperactive renin-angiotensin system (HP:0000841)3.06302627
30Short nail (HP:0001799)3.00589474
31Enlarged epiphyses (HP:0010580)2.93476675
32Insidious onset (HP:0003587)2.92808025
33Termporal pattern (HP:0011008)2.92808025
34Cardiovascular calcification (HP:0011915)2.92140388
35Aplasia involving bones of the extremities (HP:0009825)2.89372130
36Aplasia involving bones of the upper limbs (HP:0009823)2.89372130
37Aplasia of the phalanges of the hand (HP:0009802)2.89372130
38Hypomagnesemia (HP:0002917)2.88651560
39Syringomyelia (HP:0003396)2.88129290
40Spinal cord lesions (HP:0100561)2.88129290
41Vascular calcification (HP:0004934)2.85854531
42Parakeratosis (HP:0001036)2.84707150
43Glucose intolerance (HP:0000833)2.83927959
44Increased serum pyruvate (HP:0003542)2.78754768
45Flattened epiphyses (HP:0003071)2.76257087
46Hyperaldosteronism (HP:0000859)2.73185067
47Onion bulb formation (HP:0003383)2.70471575
48Abnormality of renin-angiotensin system (HP:0000847)2.68583115
49Peripheral hypomyelination (HP:0007182)2.64295019
50Absent radius (HP:0003974)2.60614983
51Coxa vara (HP:0002812)2.59189340
52Neonatal death (HP:0003811)2.58233964
53Autoimmune thrombocytopenia (HP:0001973)2.58203817
54Abnormal ossification of hand bones (HP:0005921)2.57815834
55Absent epiphyses (HP:0010577)2.57458327
56Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.57458327
57Mitral stenosis (HP:0001718)2.54355037
58Hypothermia (HP:0002045)2.53126834
59Rough bone trabeculation (HP:0100670)2.52802031
60Focal segmental glomerulosclerosis (HP:0000097)2.51221076
61Atonic seizures (HP:0010819)2.51086021
62Hypergonadotropic hypogonadism (HP:0000815)2.49105311
63Hypoplasia of the iris (HP:0007676)2.47452961
64Absent forearm bone (HP:0003953)2.46788026
65Aplasia involving forearm bones (HP:0009822)2.46788026
66Dysmetria (HP:0001310)2.45918332
67Abnormality of chloride homeostasis (HP:0011422)2.43010786
68Autoamputation (HP:0001218)2.41241557
69Renal cortical cysts (HP:0000803)2.40189558
70Abnormal hand bone ossification (HP:0010660)2.40120337
71Abnormality of oral frenula (HP:0000190)2.39039900
72Amblyopia (HP:0000646)2.37347429
73Natal tooth (HP:0000695)2.36137815
74Alacrima (HP:0000522)2.34237540
75Disproportionate short-trunk short stature (HP:0003521)2.34084768
76Pheochromocytoma (HP:0002666)2.33569454
77Thyroid-stimulating hormone excess (HP:0002925)2.33210230
78Abnormality of magnesium homeostasis (HP:0004921)2.31573459
79Abnormal auditory evoked potentials (HP:0006958)2.31478737
80Abnormality of glycolysis (HP:0004366)2.30627336
81Ankle clonus (HP:0011448)2.29358899
82Renal salt wasting (HP:0000127)2.28388169
83Thickened helices (HP:0000391)2.23104506
84Deep venous thrombosis (HP:0002625)2.22937103
85Focal seizures (HP:0007359)2.21792629
86Absent thumb (HP:0009777)2.21230541
87Spastic gait (HP:0002064)2.18148910
88Epiphyseal dysplasia (HP:0002656)2.17431861
89Abnormality of the acetabulum (HP:0003170)2.16365012
90Intention tremor (HP:0002080)2.16232590
91Striae distensae (HP:0001065)2.16162699
92Aortic dissection (HP:0002647)2.15928477
93Onycholysis (HP:0001806)2.15566724
94Aplasia/Hypoplasia of the uvula (HP:0010293)2.11112394
95Action tremor (HP:0002345)2.11091649
96Limb dystonia (HP:0002451)2.11041478
97Milia (HP:0001056)2.10489026
98Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.09389910
99Abnormality of the preputium (HP:0100587)2.08184439
100Cervical subluxation (HP:0003308)2.08031917
101Decreased circulating renin level (HP:0003351)2.07179793
102Polydipsia (HP:0001959)2.06265258
103Abnormal drinking behavior (HP:0030082)2.06265258
104Aortic aneurysm (HP:0004942)2.05735613
105Glomerulosclerosis (HP:0000096)2.03471098
106Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.00972180
107Shallow orbits (HP:0000586)2.00676686
108Akinesia (HP:0002304)1.99121095
109Scanning speech (HP:0002168)1.98287511
110Polyuria (HP:0000103)1.98194650
111Synostosis involving the elbow (HP:0003938)1.97720784
112Humeroradial synostosis (HP:0003041)1.97720784
113Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.95654624
114Abnormality of femoral epiphyses (HP:0006499)1.95654624
115Abnormal trabecular bone morphology (HP:0100671)1.94015249
116Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92218008
117Congenital sensorineural hearing impairment (HP:0008527)1.92002739
118Abnormality of potassium homeostasis (HP:0011042)1.91697052
119Hypokalemia (HP:0002900)1.91370639
120Abnormality of monocarboxylic acid metabolism (HP:0010996)1.90696915
121Nail dystrophy (HP:0008404)1.90466352
122Abnormality of the middle phalanges of the toes (HP:0010183)1.89589864
123Autoimmune hemolytic anemia (HP:0001890)1.89570846
124Abnormality of the distal phalanges of the toes (HP:0010182)1.89539330
125Stridor (HP:0010307)1.89347112
126Coronal craniosynostosis (HP:0004440)1.89061323
127Abnormality of nucleobase metabolism (HP:0010932)1.88832985
128Abnormal glucose tolerance (HP:0001952)1.87937439
129Premature rupture of membranes (HP:0001788)1.87049794
130Vascular tortuosity (HP:0004948)1.86901273
131Buphthalmos (HP:0000557)1.86884350
132Menorrhagia (HP:0000132)1.86803938
133Premature skin wrinkling (HP:0100678)1.86346391
134Flat acetabular roof (HP:0003180)1.85703323
135Abnormality of renal excretion (HP:0011036)1.85579804
136Meckel diverticulum (HP:0002245)1.85214558
137Abnormality of the nasal mucosa (HP:0000433)1.85081192
138Lower limb muscle weakness (HP:0007340)1.84826606
139Nephritis (HP:0000123)1.83517606
140Abnormality of the epiphysis of the femoral head (HP:0010574)1.83283473
141Ovoid vertebral bodies (HP:0003300)1.83164610
142Hyperkalemia (HP:0002153)1.81848160
143Megalencephaly (HP:0001355)1.81785231
144Neuroendocrine neoplasm (HP:0100634)1.81772826
145Segmental peripheral demyelination/remyelination (HP:0003481)1.81711266
146Abnormality of calcium-phosphate metabolism (HP:0100530)1.81429401
147Abnormality of the alveolar ridges (HP:0006477)1.81178850
148Short clavicles (HP:0000894)1.80536960
149Osteolytic defects of the phalanges of the hand (HP:0009771)1.80385305
150Osteolytic defects of the hand bones (HP:0009699)1.80385305
151Joint stiffness (HP:0001387)1.80063644
152Abnormal urine output (HP:0012590)1.79419760
153Infantile muscular hypotonia (HP:0008947)1.78067036
154Vaginal atresia (HP:0000148)1.78007950
155Plantar hyperkeratosis (HP:0007556)1.77506172
156Genital tract atresia (HP:0001827)1.76813206
157Fragile skin (HP:0001030)1.76771918
158Mixed hearing impairment (HP:0000410)1.76195025
159Arterial tortuosity (HP:0005116)1.76001088
160Abnormality of the ileum (HP:0001549)1.75677487
161Epileptic encephalopathy (HP:0200134)1.74816467
162Progressive cerebellar ataxia (HP:0002073)1.72679724
163Abnormality of the common coagulation pathway (HP:0010990)1.72141417
164Abnormality of the femoral head (HP:0003368)1.71907917
165Advanced eruption of teeth (HP:0006288)1.71858527
166Submucous cleft hard palate (HP:0000176)1.70231289
167Abnormality of dentin (HP:0010299)1.69572163
168Muscle fiber splitting (HP:0003555)1.68391571
169Hammertoe (HP:0001765)1.68168195
170Hyperparathyroidism (HP:0000843)1.68129802
171Hyperventilation (HP:0002883)1.67766971
172Bradycardia (HP:0001662)1.67729490
173Xerostomia (HP:0000217)1.67494006
174Joint hemorrhage (HP:0005261)1.67393707
175Joint swelling (HP:0001386)1.67178971
176Bronchomalacia (HP:0002780)1.67135254
177Adrenal overactivity (HP:0002717)1.66675852
178Cerebral hemorrhage (HP:0001342)1.65882089
179Horseshoe kidney (HP:0000085)1.65469335
180Clubbing of toes (HP:0100760)1.64676701
181Foot dorsiflexor weakness (HP:0009027)1.64608695
182Decreased lacrimation (HP:0000633)1.64402395
183Cupped ear (HP:0000378)1.63200276
184Aplasia/Hypoplasia of the clavicles (HP:0006710)1.63133634
185Rhinitis (HP:0012384)1.62353984
186Pancytopenia (HP:0001876)1.62166760
187Entropion (HP:0000621)1.59676096
188Hyporeflexia of lower limbs (HP:0002600)1.58497289
189Type II lissencephaly (HP:0007260)1.57835791
190Tetany (HP:0001281)1.57310044
191Atrophic scars (HP:0001075)1.56983719
192Abnormality of molar morphology (HP:0011070)1.54294598
193Abnormality of molar (HP:0011077)1.54294598
194Broad metatarsal (HP:0001783)1.53543888
195Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.51107761
196Taurodontia (HP:0000679)1.50529162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.92816870
2TXK4.82743510
3MAP4K14.75620219
4OXSR14.02760485
5EPHA23.37951039
6WNK43.19444059
7EPHA42.90738039
8NTRK12.76920903
9PRPF4B2.56248663
10NTRK32.30171139
11BCR2.10915234
12BCKDK2.10321892
13EPHB12.07459228
14TAOK310.6011971
15TNIK1.85786418
16ERBB41.67194267
17CAMK2B1.64319376
18MAPKAPK51.61378967
19MET1.59967736
20FER1.58026427
21MAP3K41.58013956
22ZAP701.57190474
23AKT31.55769425
24WNK11.54169516
25MAPK151.52494422
26MAP3K21.40222761
27TESK11.36634957
28CASK1.35633090
29SGK2231.35232005
30SGK4941.35232005
31TGFBR21.33442244
32PNCK1.33064811
33WNK31.31778528
34UHMK11.30926178
35PAK31.29810394
36PKN11.28602207
37CSNK1G21.27215142
38CAMK2D1.26786131
39PDGFRA1.25720935
40CSNK1G31.23023304
41MELK1.22881753
42ROCK21.20390232
43MARK11.19957697
44PAK41.15044499
45MINK11.14881648
46FGFR21.14336790
47MAP2K71.13831899
48CSNK1A1L1.13060953
49PAK61.11890630
50DDR21.11564185
51LIMK11.11068921
52CDK191.10131673
53CDK51.07031569
54NEK61.06843191
55IRAK31.06281838
56CAMK2A1.04823282
57MAP3K91.03751817
58MYLK1.03247372
59PHKG21.02530823
60PHKG11.02530823
61TTN1.01691939
62GRK51.01511702
63MST40.99529550
64LATS20.98129837
65PRKCE0.97808390
66PTK2B0.97269056
67CSNK1G10.96683108
68MARK20.93049552
69TIE10.91554706
70ARAF0.87826496
71ICK0.87021443
72GRK70.85551973
73PRKD30.84815438
74FGR0.84184728
75RIPK10.83953689
76NUAK10.83813990
77INSRR0.83153094
78KSR20.82312748
79NEK90.82200932
80LATS10.82097988
81CAMK2G0.81647183
82CAMK1G0.79877092
83CDK80.78433169
84EPHB20.78127577
85TYRO30.77925773
86CAMK1D0.77925459
87DAPK20.77689343
88LMTK20.77478096
89MAPK130.76781217
90PLK20.76700882
91MTOR0.74757256
92TESK20.74415275
93TRPM70.73721568
94STK380.73682257
95PRKAA20.73671725
96JAK10.73165090
97CDK140.72376962
98NTRK20.71028827
99NME10.68742782
100PTK20.66690411
101SIK10.64432293
102MAP2K10.61616124
103PIK3CA0.58902665
104PDPK10.58008481
105CDK150.57495043
106CDK180.56949054
107DYRK1A0.56617677
108PRKD10.55795304
109NLK0.55612171
110STK38L0.55079273
111GSK3A0.53355187
112MAP3K130.52973023
113MST1R0.52260613
114PRKCQ0.51573964
115BMPR20.51487711
116IRAK10.51101329
117RET0.50970525
118MOS0.50092982
119FES0.49526420
120PDGFRB0.49181727
121CDK11A0.49015365
122TRIB30.48929155
123STK240.48922337
124MAP2K20.48580400
125DYRK20.48299790
126FYN0.46414274
127MAP3K30.46060772
128SGK30.45301385
129PRKCG0.45189682
130TBK10.45045642
131PRKAA10.43998631
132SGK10.43107820
133CDK120.42698393
134PRKCH0.42033111
135ROCK10.41984769
136FGFR40.41468573
137KSR10.41165736
138PAK20.41157857
139FRK0.41018824
140PTK60.40699118
141FLT30.40082310
142PRKG10.39323359
143FGFR30.38800310
144PRKG20.37153729
145CAMK10.36793738
146SGK20.36313160
147ERBB30.36244595
148IGF1R0.36158713
149AKT20.34908047
150MAPK110.34606466
151TGFBR10.33094046
152STK30.32825101
153MAPKAPK30.31789512
154ERBB20.28764848
155EEF2K0.27922192
156MAP3K120.25212357
157BRSK20.24623241
158MUSK0.23301234
159FGFR10.23217106
160INSR0.22198122
161ADRBK10.20815261
162PRKD20.17970640
163SCYL20.17306650
164ERN10.17296695
165BMX0.17259394
166MAP3K50.15721529
167CDK90.15420799
168MAPKAPK20.14423793
169CDC42BPA0.12560976

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046102.83763931
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.51404156
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34866028
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.10760409
5Vitamin B6 metabolism_Homo sapiens_hsa007502.04739925
6Steroid biosynthesis_Homo sapiens_hsa001001.96531604
7Steroid hormone biosynthesis_Homo sapiens_hsa001401.93655516
8Maturity onset diabetes of the young_Homo sapiens_hsa049501.84878561
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.79786025
10Glutamatergic synapse_Homo sapiens_hsa047241.79520029
11Circadian entrainment_Homo sapiens_hsa047131.78640426
12Axon guidance_Homo sapiens_hsa043601.78106542
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.76123104
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75633092
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.75158990
16Galactose metabolism_Homo sapiens_hsa000521.72517443
17Small cell lung cancer_Homo sapiens_hsa052221.72463141
18Salivary secretion_Homo sapiens_hsa049701.72091908
19Serotonergic synapse_Homo sapiens_hsa047261.71479333
20Nicotine addiction_Homo sapiens_hsa050331.70274035
21Fatty acid elongation_Homo sapiens_hsa000621.69214013
22Amphetamine addiction_Homo sapiens_hsa050311.68598677
23Olfactory transduction_Homo sapiens_hsa047401.66347458
24Collecting duct acid secretion_Homo sapiens_hsa049661.61660387
25Gastric acid secretion_Homo sapiens_hsa049711.60634767
26GABAergic synapse_Homo sapiens_hsa047271.60311189
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59353969
28Adherens junction_Homo sapiens_hsa045201.59050369
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58569098
30Dopaminergic synapse_Homo sapiens_hsa047281.58380373
31Ether lipid metabolism_Homo sapiens_hsa005651.55653832
32Vibrio cholerae infection_Homo sapiens_hsa051101.55455406
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53126760
34Long-term potentiation_Homo sapiens_hsa047201.52108570
35Phenylalanine metabolism_Homo sapiens_hsa003601.49918415
36Morphine addiction_Homo sapiens_hsa050321.48013785
37Synaptic vesicle cycle_Homo sapiens_hsa047211.47752290
38Pancreatic secretion_Homo sapiens_hsa049721.46859640
39Bile secretion_Homo sapiens_hsa049761.44396202
40Proteoglycans in cancer_Homo sapiens_hsa052051.43898518
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.43633502
42Cocaine addiction_Homo sapiens_hsa050301.43246411
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42121263
44Taste transduction_Homo sapiens_hsa047421.41468988
45Cholinergic synapse_Homo sapiens_hsa047251.40679412
46Sulfur metabolism_Homo sapiens_hsa009201.39593352
47Pyruvate metabolism_Homo sapiens_hsa006201.39149338
48Oxidative phosphorylation_Homo sapiens_hsa001901.39147246
49Vitamin digestion and absorption_Homo sapiens_hsa049771.38887512
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38394793
51Long-term depression_Homo sapiens_hsa047301.38063135
52Renin secretion_Homo sapiens_hsa049241.37934139
53Insulin secretion_Homo sapiens_hsa049111.36914037
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.36794278
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.30969281
56Tyrosine metabolism_Homo sapiens_hsa003501.29502261
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28159036
58Primary bile acid biosynthesis_Homo sapiens_hsa001201.26900512
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24147569
60ABC transporters_Homo sapiens_hsa020101.23436211
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21577796
62Alzheimers disease_Homo sapiens_hsa050101.21549098
63Chemical carcinogenesis_Homo sapiens_hsa052041.19817941
64Sphingolipid metabolism_Homo sapiens_hsa006001.17865165
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15702915
66Retinol metabolism_Homo sapiens_hsa008301.10760866
67Vascular smooth muscle contraction_Homo sapiens_hsa042701.10089038
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08834729
69Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08283573
70Tight junction_Homo sapiens_hsa045301.07969677
71Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07266361
72ECM-receptor interaction_Homo sapiens_hsa045121.05518706
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03440119
74Mineral absorption_Homo sapiens_hsa049781.02346666
75Thyroid hormone synthesis_Homo sapiens_hsa049181.00770478
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00583046
77Calcium signaling pathway_Homo sapiens_hsa040201.00387711
78cAMP signaling pathway_Homo sapiens_hsa040240.99964778
79Gap junction_Homo sapiens_hsa045400.99610523
80Protein digestion and absorption_Homo sapiens_hsa049740.99337863
81Melanogenesis_Homo sapiens_hsa049160.98049836
82Amoebiasis_Homo sapiens_hsa051460.96858751
83GnRH signaling pathway_Homo sapiens_hsa049120.96239027
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95328011
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94046530
86Histidine metabolism_Homo sapiens_hsa003400.92182206
87Oxytocin signaling pathway_Homo sapiens_hsa049210.90039158
88Protein export_Homo sapiens_hsa030600.89814954
89Parkinsons disease_Homo sapiens_hsa050120.88998846
90Starch and sucrose metabolism_Homo sapiens_hsa005000.88568626
91Cardiac muscle contraction_Homo sapiens_hsa042600.87278922
92Ovarian steroidogenesis_Homo sapiens_hsa049130.87269168
93PPAR signaling pathway_Homo sapiens_hsa033200.86995352
94Fat digestion and absorption_Homo sapiens_hsa049750.86984543
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85484685
96Butanoate metabolism_Homo sapiens_hsa006500.84903494
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.83379351
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.83295312
99Ras signaling pathway_Homo sapiens_hsa040140.83267233
100TGF-beta signaling pathway_Homo sapiens_hsa043500.83248732
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82337006
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81380714
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.80983057
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80841598
105Estrogen signaling pathway_Homo sapiens_hsa049150.80818290
106ErbB signaling pathway_Homo sapiens_hsa040120.80203521
107Bladder cancer_Homo sapiens_hsa052190.78121694
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.77871490
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77596964
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75906945
111Choline metabolism in cancer_Homo sapiens_hsa052310.74659878
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73083499
113Arginine biosynthesis_Homo sapiens_hsa002200.72642594
114Dorso-ventral axis formation_Homo sapiens_hsa043200.72076478
115Insulin resistance_Homo sapiens_hsa049310.69231869
116Lysine degradation_Homo sapiens_hsa003100.69112724
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69017539
118Dilated cardiomyopathy_Homo sapiens_hsa054140.67865045
119Phototransduction_Homo sapiens_hsa047440.66358200
120Hedgehog signaling pathway_Homo sapiens_hsa043400.65686822
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65642896
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64779309
123Linoleic acid metabolism_Homo sapiens_hsa005910.64695065
124Prion diseases_Homo sapiens_hsa050200.63041912
125Pertussis_Homo sapiens_hsa051330.61641813
126Fatty acid degradation_Homo sapiens_hsa000710.61249910
127Propanoate metabolism_Homo sapiens_hsa006400.61162571
128Wnt signaling pathway_Homo sapiens_hsa043100.60968701
129N-Glycan biosynthesis_Homo sapiens_hsa005100.59928267
130Rap1 signaling pathway_Homo sapiens_hsa040150.59805841
131Pancreatic cancer_Homo sapiens_hsa052120.59133246
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57745887
133Arginine and proline metabolism_Homo sapiens_hsa003300.57681837
134Platelet activation_Homo sapiens_hsa046110.57087167
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56970794
136Renal cell carcinoma_Homo sapiens_hsa052110.56474336
137Circadian rhythm_Homo sapiens_hsa047100.56412197
138Focal adhesion_Homo sapiens_hsa045100.55786391
139Endocytosis_Homo sapiens_hsa041440.55647344
140Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55046224
141Pathways in cancer_Homo sapiens_hsa052000.53849396
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53368325
143Melanoma_Homo sapiens_hsa052180.52576999
144Type II diabetes mellitus_Homo sapiens_hsa049300.50536881
145Hippo signaling pathway_Homo sapiens_hsa043900.50132578
146Glycerolipid metabolism_Homo sapiens_hsa005610.49948366
147Fatty acid biosynthesis_Homo sapiens_hsa000610.49279449
148Huntingtons disease_Homo sapiens_hsa050160.47774111
149Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47170168
150Drug metabolism - other enzymes_Homo sapiens_hsa009830.46690815
151Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46666963
152Arachidonic acid metabolism_Homo sapiens_hsa005900.45054519
153Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44856734
154Rheumatoid arthritis_Homo sapiens_hsa053230.44850770
155Renin-angiotensin system_Homo sapiens_hsa046140.43023053
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.42329930
157MicroRNAs in cancer_Homo sapiens_hsa052060.39718359
158Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37872875
159Glucagon signaling pathway_Homo sapiens_hsa049220.37462239
160Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35619766
161Lysosome_Homo sapiens_hsa041420.35575200
162beta-Alanine metabolism_Homo sapiens_hsa004100.33319344
163TNF signaling pathway_Homo sapiens_hsa046680.32529750
164Glioma_Homo sapiens_hsa052140.30949888

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