ARHGEF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.35124048
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.20316532
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.20316532
4antigen processing and presentation of endogenous antigen (GO:0019883)5.83684453
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.45514167
6negative regulation of cell killing (GO:0031342)5.45514167
7regulation of gamma-delta T cell differentiation (GO:0045586)5.14594003
8negative T cell selection (GO:0043383)4.99981688
9positive thymic T cell selection (GO:0045059)4.95980131
10negative thymic T cell selection (GO:0045060)4.95204506
11regulation of gamma-delta T cell activation (GO:0046643)4.91993467
12regulation of interleukin-12 biosynthetic process (GO:0045075)4.84636108
13positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.77704120
14response to interleukin-15 (GO:0070672)4.51685291
15regulation of B cell receptor signaling pathway (GO:0050855)4.48205855
16T cell migration (GO:0072678)4.47181792
17positive T cell selection (GO:0043368)4.43435744
18regulation of isotype switching to IgG isotypes (GO:0048302)4.40125773
19regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.39273169
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.36054157
21thymic T cell selection (GO:0045061)4.25109461
22leukocyte aggregation (GO:0070486)4.15493829
23cellular response to interleukin-15 (GO:0071350)4.07542947
24T cell selection (GO:0045058)4.06702225
25positive regulation of humoral immune response (GO:0002922)3.89049066
26positive regulation of granulocyte differentiation (GO:0030854)3.85657697
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.82170510
28regulation of alpha-beta T cell proliferation (GO:0046640)3.81715301
29interferon-gamma production (GO:0032609)3.65729103
30positive regulation of alpha-beta T cell proliferation (GO:0046641)3.61673084
31NIK/NF-kappaB signaling (GO:0038061)3.58253933
32neutrophil activation involved in immune response (GO:0002283)3.55088287
33negative regulation of T cell mediated immunity (GO:0002710)3.49461945
34positive regulation of immunoglobulin mediated immune response (GO:0002891)3.47121527
35positive regulation of B cell mediated immunity (GO:0002714)3.47121527
36positive regulation of isotype switching (GO:0045830)3.45843149
37regulation of T cell tolerance induction (GO:0002664)3.39168055
38antigen processing and presentation via MHC class Ib (GO:0002475)3.39111911
39positive regulation of interleukin-2 production (GO:0032743)3.37248335
40T cell costimulation (GO:0031295)3.34769818
41regulation of regulatory T cell differentiation (GO:0045589)3.33814911
42interferon-gamma-mediated signaling pathway (GO:0060333)3.30130213
43lymphocyte costimulation (GO:0031294)3.28984032
44regulation of T cell mediated cytotoxicity (GO:0001914)3.27950011
45detection of other organism (GO:0098543)3.23315729
46tolerance induction (GO:0002507)3.22682338
47JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.22376846
48regulation of response to interferon-gamma (GO:0060330)3.21880803
49regulation of interleukin-2 biosynthetic process (GO:0045076)3.21664926
50T cell receptor signaling pathway (GO:0050852)3.20260636
51regulation of B cell differentiation (GO:0045577)3.19358297
52immunoglobulin mediated immune response (GO:0016064)3.18065384
53activated T cell proliferation (GO:0050798)3.17863566
54B cell receptor signaling pathway (GO:0050853)3.17292820
55regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.16208582
56detection of bacterium (GO:0016045)3.15335101
57leukocyte cell-cell adhesion (GO:0007159)3.12820386
58myeloid dendritic cell differentiation (GO:0043011)3.11260394
59cytidine metabolic process (GO:0046087)3.10268093
60cytidine catabolic process (GO:0006216)3.10268093
61cytidine deamination (GO:0009972)3.10268093
62response to type I interferon (GO:0034340)3.08573094
63neutrophil activation (GO:0042119)3.08122556
64regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.06946194
65regulation of type I interferon-mediated signaling pathway (GO:0060338)3.05216782
66type I interferon signaling pathway (GO:0060337)3.04927161
67cellular response to type I interferon (GO:0071357)3.04927161
68antigen receptor-mediated signaling pathway (GO:0050851)3.04453976
69positive regulation of T cell mediated cytotoxicity (GO:0001916)3.03439290
70negative regulation of interleukin-12 production (GO:0032695)3.01015407
71positive regulation of B cell differentiation (GO:0045579)2.99682446
72macrophage activation involved in immune response (GO:0002281)2.99568717
73myeloid dendritic cell activation (GO:0001773)2.98090797
74negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.97926865
75positive regulation by symbiont of host defense response (GO:0052509)2.97309371
76modulation by symbiont of host defense response (GO:0052031)2.97309371
77modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.97309371
78modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.97309371
79positive regulation by organism of defense response of other organism involved in symbiotic interact2.97309371
80modulation by symbiont of host immune response (GO:0052553)2.97309371
81regulation of immunoglobulin mediated immune response (GO:0002889)2.95362292
82myeloid cell activation involved in immune response (GO:0002275)2.95093023
83regulation of natural killer cell mediated immunity (GO:0002715)2.93918580
84regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.93918580
85pyrimidine ribonucleoside catabolic process (GO:0046133)2.92935004
86negative regulation of lymphocyte mediated immunity (GO:0002707)2.92780036
87regulation of B cell mediated immunity (GO:0002712)2.91484665
88positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.89149007
89granulocyte activation (GO:0036230)2.87814332
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.87435259
91positive regulation of DNA recombination (GO:0045911)2.87041077
92mast cell activation (GO:0045576)2.86701130
93natural killer cell activation (GO:0030101)2.86084379
94cellular extravasation (GO:0045123)2.84648693
95negative regulation of innate immune response (GO:0045824)2.84573806
96leukocyte degranulation (GO:0043299)2.81682564
97dendritic cell chemotaxis (GO:0002407)2.80653686
98positive regulation of tolerance induction (GO:0002645)2.79551416
99regulation of isotype switching (GO:0045191)2.79214223
100response to protozoan (GO:0001562)2.78927409
101negative regulation of adaptive immune response (GO:0002820)2.78786765
102lymphocyte migration (GO:0072676)2.78536508
103T cell proliferation (GO:0042098)2.77669105
104negative regulation of type 2 immune response (GO:0002829)2.75883701
105positive regulation of immunoglobulin production (GO:0002639)2.75858868
106negative regulation of glycoprotein biosynthetic process (GO:0010561)2.75468179
107positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.74026646
108positive regulation of natural killer cell mediated immunity (GO:0002717)2.74026646
109positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.71846040
110regulation of leukocyte mediated cytotoxicity (GO:0001910)2.71313574
111negative regulation of leukocyte mediated immunity (GO:0002704)2.70203174
112T cell homeostasis (GO:0043029)2.67564460
113dendritic cell migration (GO:0036336)2.67190718
114defense response to protozoan (GO:0042832)2.66983674
115lipopolysaccharide-mediated signaling pathway (GO:0031663)2.66361598
116regulation of granulocyte differentiation (GO:0030852)2.65837357
117positive regulation of cell killing (GO:0031343)2.64981439
118positive regulation of interleukin-12 production (GO:0032735)2.63769281
119regulation of interleukin-12 production (GO:0032655)2.63527029
120regulation of tolerance induction (GO:0002643)2.63506808
121regulation of T cell receptor signaling pathway (GO:0050856)2.63154764
122regulation of alpha-beta T cell activation (GO:0046634)2.62907734
123positive regulation of cytokine biosynthetic process (GO:0042108)2.62655123
124regulation of cell killing (GO:0031341)2.62355602
125positive regulation of interleukin-4 production (GO:0032753)2.62070944
126regulation of T-helper 1 cell differentiation (GO:0045625)2.61957963
127negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.60995429
128negative regulation of T-helper cell differentiation (GO:0045623)2.60700346
129negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.60700346
130regulation of immunoglobulin production (GO:0002637)2.59909513
131regulation of interleukin-2 production (GO:0032663)2.59548573
132positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.58762401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.00220673
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.77262612
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.85841642
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.73032097
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.71942541
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.58021465
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.57023153
8RUNX_20019798_ChIP-Seq_JUKART_Human3.41764279
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.32258005
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.09404012
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.06901008
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.98193711
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.96430231
14* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.93547924
15* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.70807245
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64133594
17MYC_22102868_ChIP-Seq_BL_Human2.62162841
18* MYB_26560356_Chip-Seq_TH2_Human2.57373458
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.50769083
20MAF_26560356_Chip-Seq_TH1_Human2.44597488
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.44136851
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.36711187
23MYB_26560356_Chip-Seq_TH1_Human2.19661485
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.10895094
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.02744151
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.01544580
27UTX_26944678_Chip-Seq_JUKART_Human1.97865813
28GATA1_22025678_ChIP-Seq_K562_Human1.96851849
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.96033016
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94670139
31TCF7_22412390_ChIP-Seq_EML_Mouse1.85852010
32* GATA3_27048872_Chip-Seq_THYMUS_Human1.85652086
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.81255742
34SPI1_23127762_ChIP-Seq_K562_Human1.80064189
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78832877
36VDR_21846776_ChIP-Seq_THP-1_Human1.73722392
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73544973
38* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.73332308
39* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70815372
40VDR_24763502_ChIP-Seq_THP-1_Human1.70047699
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68796303
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66624638
43SCL_19346495_ChIP-Seq_HPC-7_Human1.65614021
44KDM2B_26808549_Chip-Seq_DND41_Human1.64478881
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59701502
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.58860912
47PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54812559
48SPI1_23547873_ChIP-Seq_NB4_Human1.51940585
49MAF_26560356_Chip-Seq_TH2_Human1.45799625
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.42029443
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38631445
52PU_27001747_Chip-Seq_BMDM_Mouse1.34150887
53GATA3_26560356_Chip-Seq_TH2_Human1.31364287
54ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.30257959
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.29985039
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29089024
57VDR_24787735_ChIP-Seq_THP-1_Human1.28682560
58* NOTCH1_21737748_ChIP-Seq_TLL_Human1.25448243
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.22228184
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20670153
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16763724
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14563558
63* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14458255
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14436504
65GATA1_19941826_ChIP-Seq_K562_Human1.14154512
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14002802
67* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13195819
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12100154
69GATA2_19941826_ChIP-Seq_K562_Human1.10238953
70RXR_22158963_ChIP-Seq_LIVER_Mouse1.10067250
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10062450
72* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09309308
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08933001
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08698376
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.08577527
76* LXR_22158963_ChIP-Seq_LIVER_Mouse1.07488608
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05725164
78FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.04316773
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04243318
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04155363
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03414907
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.00597622
83* LXR_22292898_ChIP-Seq_THP-1_Human0.99940336
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97334027
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96466043
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95325446
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93674400
88CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92618053
89* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91750358
90* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88186279
91ESR2_21235772_ChIP-Seq_MCF-7_Human0.86109129
92NCOR1_26117541_ChIP-Seq_K562_Human0.83802150
93CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83727893
94GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83613281
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83178992
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82188724
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80992505
98CLOCK_20551151_ChIP-Seq_293T_Human0.79748293
99NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.77986685
100GATA3_26560356_Chip-Seq_TH1_Human0.75210203
101SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.74721204
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.72283116
103GATA1_22383799_ChIP-Seq_G1ME_Mouse0.72280303
104* PRDM14_20953172_ChIP-Seq_ESCs_Human0.72080221
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.70454267
106SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69176566
107* SMRT_27268052_Chip-Seq_Bcells_Human0.68864762
108* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67836408
109CDX2_19796622_ChIP-Seq_MESCs_Mouse0.67336046
110* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.66807281
111* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.66200034
112VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.65565110
113CIITA_25753668_ChIP-Seq_RAJI_Human0.63920393
114* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.63749731
115DROSHA_22980978_ChIP-Seq_HELA_Human0.59449722

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.49929980
2MP0005671_abnormal_response_to3.35375643
3MP0009785_altered_susceptibility_to3.26842129
4MP0000685_abnormal_immune_system3.20192045
5MP0005387_immune_system_phenotype3.05641962
6MP0001790_abnormal_immune_system3.05641962
7MP0003763_abnormal_thymus_physiology2.97169157
8MP0003303_peritoneal_inflammation2.96990026
9MP0001800_abnormal_humoral_immune2.96434067
10MP0003436_decreased_susceptibility_to2.96276215
11MP0005000_abnormal_immune_tolerance2.89748980
12MP0003724_increased_susceptibility_to2.73663975
13MP0006082_CNS_inflammation2.61626859
14MP0002723_abnormal_immune_serum2.60046283
15MP0005025_abnormal_response_to2.53083645
16MP0002452_abnormal_antigen_presenting2.51667392
17MP0003300_gastrointestinal_ulcer2.49293199
18MP0002420_abnormal_adaptive_immunity2.45220030
19MP0004510_myositis2.44769844
20MP0001819_abnormal_immune_cell2.43280535
21MP0002148_abnormal_hypersensitivity_rea2.39219177
22MP0002419_abnormal_innate_immunity2.33655184
23MP0002138_abnormal_hepatobiliary_system2.29366918
24MP0002166_altered_tumor_susceptibility2.22629750
25MP0004947_skin_inflammation2.11352358
26MP0002398_abnormal_bone_marrow2.08849198
27MP0002006_tumorigenesis2.08196282
28MP0002405_respiratory_system_inflammati2.06678263
29MP0000716_abnormal_immune_system1.97205313
30MP0001873_stomach_inflammation1.96197689
31MP0010155_abnormal_intestine_physiology1.94406208
32MP0009333_abnormal_splenocyte_physiolog1.93335595
33MP0005464_abnormal_platelet_physiology1.91892779
34MP0001845_abnormal_inflammatory_respons1.82221668
35MP0004381_abnormal_hair_follicle1.79416595
36MP0000689_abnormal_spleen_morphology1.71065946
37MP0003866_abnormal_defecation1.71004575
38MP0001853_heart_inflammation1.67608117
39MP0000604_amyloidosis1.62548948
40MP0002722_abnormal_immune_system1.60896768
41MP0002429_abnormal_blood_cell1.56998199
42MP0003191_abnormal_cellular_cholesterol1.55654016
43MP0008469_abnormal_protein_level1.47284145
44MP0001533_abnormal_skeleton_physiology1.46176117
45MP0009764_decreased_sensitivity_to1.42846052
46MP0005310_abnormal_salivary_gland1.42345151
47MP0005075_abnormal_melanosome_morpholog1.37609490
48MP0000703_abnormal_thymus_morphology1.35593269
49MP0003075_altered_response_to1.31052148
50MP0002009_preneoplasia1.27366754
51MP0005167_abnormal_blood-brain_barrier1.26505028
52MP0005397_hematopoietic_system_phenotyp1.25125215
53MP0001545_abnormal_hematopoietic_system1.25125215
54MP0009278_abnormal_bone_marrow1.24499985
55MP0002396_abnormal_hematopoietic_system1.20761094
56MP0002132_abnormal_respiratory_system1.20501371
57MP0003172_abnormal_lysosome_physiology1.19888989
58MP0003448_altered_tumor_morphology1.19706305
59MP0005166_decreased_susceptibility_to1.15920440
60MP0005058_abnormal_lysosome_morphology1.15607478
61MP0002254_reproductive_system_inflammat1.13448259
62MP0002933_joint_inflammation1.12782556
63MP0000465_gastrointestinal_hemorrhage1.12526844
64MP0004883_abnormal_blood_vessel1.10889092
65MP0003045_fibrosis1.10032857
66MP0009840_abnormal_foam_cell1.08792735
67MP0004808_abnormal_hematopoietic_stem1.07804057
68MP0008260_abnormal_autophagy1.06081643
69MP0002822_catalepsy1.02119308
70MP0008961_abnormal_basal_metabolism1.01017204
71MP0000343_altered_response_to1.00060541
72MP0000609_abnormal_liver_physiology0.96903673
73MP0002998_abnormal_bone_remodeling0.96234572
74MP0000858_altered_metastatic_potential0.96151625
75MP0000920_abnormal_myelination0.93326174
76MP0001501_abnormal_sleep_pattern0.93260258
77MP0003183_abnormal_peptide_metabolism0.92154459
78MP0000569_abnormal_digit_pigmentation0.91607591
79MP0001851_eye_inflammation0.91135120
80MP0002277_abnormal_respiratory_mucosa0.90841005
81MP0003828_pulmonary_edema0.88117345
82MP0009763_increased_sensitivity_to0.87607151
83MP0002693_abnormal_pancreas_physiology0.86802873
84MP0010234_abnormal_vibrissa_follicle0.86350141
85MP0004859_abnormal_synaptic_plasticity0.86145735
86MP0005360_urolithiasis0.85291930
87MP0000249_abnormal_blood_vessel0.84351532
88MP0008874_decreased_physiological_sensi0.83102222
89MP0004130_abnormal_muscle_cell0.81631764
90MP0002136_abnormal_kidney_physiology0.79888672
91MP0003329_amyloid_beta_deposits0.78459401
92MP0005076_abnormal_cell_differentiation0.76531062
93MP0003453_abnormal_keratinocyte_physiol0.76325517
94MP0003787_abnormal_imprinting0.76146814
95MP0005164_abnormal_response_to0.74702737
96MP0003690_abnormal_glial_cell0.73673098
97MP0009765_abnormal_xenobiotic_induced0.72721069
98MP0005584_abnormal_enzyme/coenzyme_acti0.72339197
99MP0003091_abnormal_cell_migration0.71510365
100MP0000015_abnormal_ear_pigmentation0.70759659
101MP0004484_altered_response_of0.65987208
102MP0005451_abnormal_body_composition0.65368364
103MP0008569_lethality_at_weaning0.65192434
104MP0005365_abnormal_bile_salt0.62607120
105MP0001986_abnormal_taste_sensitivity0.62417421
106MP0001881_abnormal_mammary_gland0.62335113
107MP0002909_abnormal_adrenal_gland0.60314715
108MP0008004_abnormal_stomach_pH0.58674548
109MP0010368_abnormal_lymphatic_system0.58492834
110MP0004782_abnormal_surfactant_physiolog0.58391245
111MP0010329_abnormal_lipoprotein_level0.57602914
112MP0003795_abnormal_bone_structure0.57001277
113MP0001663_abnormal_digestive_system0.56798189
114MP0009643_abnormal_urine_homeostasis0.56078814
115MP0003656_abnormal_erythrocyte_physiolo0.55832812
116MP0005319_abnormal_enzyme/_coenzyme0.55448779
117MP0001765_abnormal_ion_homeostasis0.54923627
118MP0005535_abnormal_body_temperature0.53851608
119MP0003566_abnormal_cell_adhesion0.52575040
120MP0008057_abnormal_DNA_replication0.51090282
121MP0005390_skeleton_phenotype0.50282914
122MP0003633_abnormal_nervous_system0.48745689
123MP0002133_abnormal_respiratory_system0.48128817
124MP0005388_respiratory_system_phenotype0.48128817

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.02152058
2Eczematoid dermatitis (HP:0000976)4.97685519
3T lymphocytopenia (HP:0005403)4.47634409
4Abnormality of T cell number (HP:0011839)4.39001333
5Recurrent abscess formation (HP:0002722)4.36716165
6Elevated erythrocyte sedimentation rate (HP:0003565)4.33459556
7Chronic otitis media (HP:0000389)4.20167979
8Abnormality of the nasal mucosa (HP:0000433)4.18127133
9Recurrent fungal infections (HP:0002841)4.16308593
10Pustule (HP:0200039)4.08326035
11Nasal polyposis (HP:0100582)4.06388551
12Recurrent bronchitis (HP:0002837)3.92730587
13Recurrent bacterial skin infections (HP:0005406)3.89939204
14Recurrent viral infections (HP:0004429)3.89722811
15Myositis (HP:0100614)3.88168438
16Recurrent gram-negative bacterial infections (HP:0005420)3.73800299
17Spontaneous hematomas (HP:0007420)3.63861940
18Mediastinal lymphadenopathy (HP:0100721)3.56605547
19Abnormality of T cells (HP:0002843)3.43213359
20Interstitial pulmonary disease (HP:0006530)3.33170291
21IgM deficiency (HP:0002850)3.25479368
22Hematochezia (HP:0002573)3.24183126
23Joint swelling (HP:0001386)3.16951544
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.11273393
25Papilledema (HP:0001085)3.11075085
26Autoimmune thrombocytopenia (HP:0001973)3.10810120
27Orchitis (HP:0100796)3.10407950
28Colitis (HP:0002583)3.08158323
29Vasculitis (HP:0002633)3.08086901
30Inflammation of the large intestine (HP:0002037)3.04931030
31Retrobulbar optic neuritis (HP:0100654)3.03315846
32Optic neuritis (HP:0100653)3.03315846
33Panhypogammaglobulinemia (HP:0003139)3.03092013
34Chronic mucocutaneous candidiasis (HP:0002728)3.01877829
35Recurrent cutaneous fungal infections (HP:0011370)3.01877829
36Arterial thrombosis (HP:0004420)2.98903649
37Recurrent skin infections (HP:0001581)2.97356470
38Abnormality of macrophages (HP:0004311)2.96567351
39Gastrointestinal infarctions (HP:0005244)2.96240919
40Gastrointestinal inflammation (HP:0004386)2.92993152
41Pulmonary infiltrates (HP:0002113)2.87446969
42Polycythemia (HP:0001901)2.82065225
43Agammaglobulinemia (HP:0004432)2.79342845
44IgG deficiency (HP:0004315)2.76323243
45Meningitis (HP:0001287)2.76279820
46Gingivitis (HP:0000230)2.70221469
47Combined immunodeficiency (HP:0005387)2.66599801
48Increased IgE level (HP:0003212)2.65506385
49Increased IgM level (HP:0003496)2.65155392
50Chronic diarrhea (HP:0002028)2.63610165
51Hemoptysis (HP:0002105)2.57826281
52Fatigue (HP:0012378)2.56963287
53Chronic sinusitis (HP:0011109)2.55269839
54Cellulitis (HP:0100658)2.53022481
55Verrucae (HP:0200043)2.52868340
56Papilloma (HP:0012740)2.52868340
57Pulmonary embolism (HP:0002204)2.52672557
58Lymphopenia (HP:0001888)2.52013933
59Severe combined immunodeficiency (HP:0004430)2.49611426
60Systemic lupus erythematosus (HP:0002725)2.47029086
61Periodontitis (HP:0000704)2.46897622
62Abnormality of T cell physiology (HP:0011840)2.46712325
63Gingival bleeding (HP:0000225)2.46537737
64Purpura (HP:0000979)2.45027332
65Slow saccadic eye movements (HP:0000514)2.44602844
66Keratoconjunctivitis sicca (HP:0001097)2.44243097
67Leukocytosis (HP:0001974)2.43878874
68Chronic obstructive pulmonary disease (HP:0006510)2.43189238
69Obstructive lung disease (HP:0006536)2.43189238
70Thrombocytosis (HP:0001894)2.42502922
71Abnormality of cells of the lymphoid lineage (HP:0012140)2.42344087
72Hemiplegia (HP:0002301)2.39031742
73IgA deficiency (HP:0002720)2.33721312
74Abnormality of binocular vision (HP:0011514)2.33423274
75Diplopia (HP:0000651)2.33423274
76Epistaxis (HP:0000421)2.33277104
77Chest pain (HP:0100749)2.32634253
78Eosinophilia (HP:0001880)2.32601198
79Myocardial infarction (HP:0001658)2.32502511
80Bronchitis (HP:0012387)2.32430073
81Esophageal varix (HP:0002040)2.31902066
82Petechiae (HP:0000967)2.30643869
83Keratoconjunctivitis (HP:0001096)2.29637602
84Abnormality of eosinophils (HP:0001879)2.28770090
85Gastrointestinal stroma tumor (HP:0100723)2.28231818
86Hypergammaglobulinemia (HP:0010702)2.25506539
87Acute hepatic failure (HP:0006554)2.23223971
88Urticaria (HP:0001025)2.21569754
89Thyroiditis (HP:0100646)2.20830608
90Abnormality of the fingertips (HP:0001211)2.18980559
91Encephalitis (HP:0002383)2.18897895
92Recurrent sinusitis (HP:0011108)2.18374673
93Abnormality of the prostate (HP:0008775)2.15569016
94Episodic fever (HP:0001954)2.14747629
95Gangrene (HP:0100758)2.14124753
96Hypoplasia of the thymus (HP:0000778)2.13425197
97Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.07883898
98B lymphocytopenia (HP:0010976)2.04242548
99Abnormality of B cell number (HP:0010975)2.04242548
100Emphysema (HP:0002097)2.02161832
101Loss of speech (HP:0002371)1.99781334
102Abnormality of the pleura (HP:0002103)1.99535712
103Thrombophlebitis (HP:0004418)1.98442780
104Abnormal platelet volume (HP:0011876)1.98216216
105Osteomyelitis (HP:0002754)1.96415566
106Autoimmune hemolytic anemia (HP:0001890)1.94746212
107Prolonged bleeding time (HP:0003010)1.90115415
108Increased CSF protein (HP:0002922)1.89828441
109Sepsis (HP:0100806)1.89161229
110Vertigo (HP:0002321)1.88928342
111Basal ganglia calcification (HP:0002135)1.87200735
112Mitral stenosis (HP:0001718)1.87098492
113Glomerulopathy (HP:0100820)1.86425374
114Granulocytopenia (HP:0001913)1.86405145
115Skin ulcer (HP:0200042)1.86024599
116Vacuolated lymphocytes (HP:0001922)1.84472132
117Supranuclear gaze palsy (HP:0000605)1.84195979
118Restrictive lung disease (HP:0002091)1.84045213
119Arthralgia (HP:0002829)1.83301589
120Increased cerebral lipofuscin (HP:0011813)1.82594436
121Acne (HP:0001061)1.82405171
122Increased density of long bones (HP:0006392)1.80790599
123Stomach cancer (HP:0012126)1.79866803
124Cerebral hemorrhage (HP:0001342)1.79675395
125Anorexia (HP:0002039)1.78135283
126Hypoproteinemia (HP:0003075)1.77963540
127Neoplasm of the tracheobronchial system (HP:0100552)1.75391710
128Viral hepatitis (HP:0006562)1.75238276
129Polyneuropathy (HP:0001271)1.74415374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.22228550
2TXK4.16133868
3JAK33.06946086
4MAP3K143.00840981
5TYK22.78341954
6ZAP702.63345084
7IKBKE2.47458223
8JAK12.41268929
9MAP3K132.40998756
10FGFR42.39500852
11RIPK42.39017673
12STK102.36430006
13TBK12.29077637
14ITK2.19558983
15GRK62.11924363
16CSK2.02476744
17BLK1.94268522
18PRPF4B1.81743318
19TGFBR21.78270814
20FGFR31.70037866
21FES1.66175179
22BMPR21.61299481
23ERN11.55173443
24IKBKB1.53952260
25SYK1.53711998
26LCK1.42411467
27HCK1.41734914
28IRAK31.32060488
29BTK1.31355743
30IRAK41.30850145
31PRKCH1.30312072
32JAK21.28603559
33KIT1.26639515
34TEC1.25910395
35EEF2K1.25247231
36MARK31.19421549
37LRRK21.18767869
38MST41.16784655
39EPHB11.14978056
40TRIB31.13521217
41CHUK1.12987188
42SIK21.12897501
43KDR1.11044764
44RIPK11.08981570
45MAP3K71.05353390
46MAP3K121.04344014
47PRKCQ0.98255000
48MAP3K100.95922161
49PDK10.95682039
50CSF1R0.89041003
51NLK0.88294047
52HIPK20.87884895
53PKN20.83909286
54TAOK10.82560324
55STK380.81616059
56LYN0.81436747
57PIM10.79542077
58MAP2K30.79346226
59DAPK20.77784310
60TESK20.77196616
61PASK0.76934025
62SGK20.74842294
63PIK3CG0.73683264
64TIE10.71564521
65KSR20.70049192
66FGR0.69963446
67MAP2K60.69899590
68MARK20.68857816
69ALK0.68326607
70DAPK10.68176560
71NEK60.66532835
72SCYL20.65460675
73TYRO30.65094241
74NEK90.64766665
75PTK60.64709434
76GRK50.61468809
77YES10.60005656
78TRPM70.54536890
79RPS6KA40.54163542
80SGK30.53921745
81CAMKK10.52715371
82CAMKK20.52247120
83FYN0.51757350
84RAF10.51306760
85PDPK10.49711790
86TAOK30.48620810
87WNK10.47848551
88EGFR0.46455759
89SIK30.45830584
90MAP3K10.43953311
91MAPK110.42142177
92MAPK120.41801516
93TTN0.40481066
94MAP3K20.40357536
95MAP3K30.39726055
96FLT30.39535882
97MAP3K110.38687092
98FRK0.38385844
99SGK4940.38319690
100SGK2230.38319690
101MAP3K90.37110546
102PRKD20.36216507
103PDGFRB0.36146835
104EPHA40.34872921
105IGF1R0.34844876
106DMPK0.34645494
107SIK10.34117191
108GRK70.34074460
109TNK20.33946886
110STK240.33038054
111INSR0.32629781
112IRAK10.30920037
113RET0.30726937
114STK110.29527357
115PTK2B0.29190843
116NTRK30.28925828
117MAPK70.28515648
118PRKCD0.28512093
119CDC42BPA0.28145492
120ABL10.28058140
121EPHA30.27675841
122MAP3K50.27630394
123TSSK60.26451523

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.11569795
2Graft-versus-host disease_Homo sapiens_hsa053323.05033251
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.56347387
4Allograft rejection_Homo sapiens_hsa053302.55892043
5Leishmaniasis_Homo sapiens_hsa051402.53937998
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.51691093
7T cell receptor signaling pathway_Homo sapiens_hsa046602.46038965
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.34445889
9Osteoclast differentiation_Homo sapiens_hsa043802.29922400
10Staphylococcus aureus infection_Homo sapiens_hsa051502.25097628
11Measles_Homo sapiens_hsa051622.15779482
12Type I diabetes mellitus_Homo sapiens_hsa049402.09700415
13B cell receptor signaling pathway_Homo sapiens_hsa046622.04624165
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.00707025
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81632603
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.77634296
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74939380
18Antigen processing and presentation_Homo sapiens_hsa046121.73046473
19Hematopoietic cell lineage_Homo sapiens_hsa046401.72886218
20Tuberculosis_Homo sapiens_hsa051521.60028940
21Legionellosis_Homo sapiens_hsa051341.57658785
22Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.54347379
23TNF signaling pathway_Homo sapiens_hsa046681.54146303
24Chemokine signaling pathway_Homo sapiens_hsa040621.50473314
25Toxoplasmosis_Homo sapiens_hsa051451.46782018
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.45940989
27Pertussis_Homo sapiens_hsa051331.44690026
28Rheumatoid arthritis_Homo sapiens_hsa053231.44452110
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38378311
30African trypanosomiasis_Homo sapiens_hsa051431.30144538
31Influenza A_Homo sapiens_hsa051641.29810880
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25775324
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24589144
34Malaria_Homo sapiens_hsa051441.22835844
35Autoimmune thyroid disease_Homo sapiens_hsa053201.19967952
36Asthma_Homo sapiens_hsa053101.18499265
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16774804
38Salmonella infection_Homo sapiens_hsa051321.15875065
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.15196294
40Herpes simplex infection_Homo sapiens_hsa051681.14698251
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12911430
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11826063
43Viral myocarditis_Homo sapiens_hsa054161.03282355
44Hepatitis B_Homo sapiens_hsa051611.02443885
45Shigellosis_Homo sapiens_hsa051311.02335632
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01423669
47Acute myeloid leukemia_Homo sapiens_hsa052210.98762914
48Hepatitis C_Homo sapiens_hsa051600.94271748
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.92912533
50Apoptosis_Homo sapiens_hsa042100.86948075
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86334361
52Platelet activation_Homo sapiens_hsa046110.85734511
53Caffeine metabolism_Homo sapiens_hsa002320.81172843
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79253767
55VEGF signaling pathway_Homo sapiens_hsa043700.78146670
56Nitrogen metabolism_Homo sapiens_hsa009100.76070349
57Pancreatic cancer_Homo sapiens_hsa052120.75599650
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.75595527
59Complement and coagulation cascades_Homo sapiens_hsa046100.73841468
60Prolactin signaling pathway_Homo sapiens_hsa049170.73413114
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71109181
62Amoebiasis_Homo sapiens_hsa051460.70665272
63Insulin resistance_Homo sapiens_hsa049310.70029788
64Other glycan degradation_Homo sapiens_hsa005110.69541991
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67360169
66Long-term potentiation_Homo sapiens_hsa047200.66023728
67Chronic myeloid leukemia_Homo sapiens_hsa052200.64708704
68Renal cell carcinoma_Homo sapiens_hsa052110.61715103
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61234781
70GnRH signaling pathway_Homo sapiens_hsa049120.59183067
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58863813
72Choline metabolism in cancer_Homo sapiens_hsa052310.58453345
73Circadian rhythm_Homo sapiens_hsa047100.57614626
74Regulation of autophagy_Homo sapiens_hsa041400.56463535
75Arginine biosynthesis_Homo sapiens_hsa002200.55218296
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53967553
77mTOR signaling pathway_Homo sapiens_hsa041500.53181453
78Type II diabetes mellitus_Homo sapiens_hsa049300.51887462
79Endocytosis_Homo sapiens_hsa041440.51720234
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51126065
81Olfactory transduction_Homo sapiens_hsa047400.50421456
82MAPK signaling pathway_Homo sapiens_hsa040100.48965626
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48909227
84Ras signaling pathway_Homo sapiens_hsa040140.48590241
85Glioma_Homo sapiens_hsa052140.47796775
86Inositol phosphate metabolism_Homo sapiens_hsa005620.47735141
87Renin secretion_Homo sapiens_hsa049240.47312276
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47309360
89Prion diseases_Homo sapiens_hsa050200.46680958
90Colorectal cancer_Homo sapiens_hsa052100.45937224
91Endometrial cancer_Homo sapiens_hsa052130.45243030
92Lysosome_Homo sapiens_hsa041420.45234063
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.43470723
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42854011
95HTLV-I infection_Homo sapiens_hsa051660.41820357
96Pancreatic secretion_Homo sapiens_hsa049720.41727322
97Non-small cell lung cancer_Homo sapiens_hsa052230.41393572
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.41393261
99Gastric acid secretion_Homo sapiens_hsa049710.40968635
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39543547
101FoxO signaling pathway_Homo sapiens_hsa040680.38625010
102Viral carcinogenesis_Homo sapiens_hsa052030.38491150
103Salivary secretion_Homo sapiens_hsa049700.37926521
104Dorso-ventral axis formation_Homo sapiens_hsa043200.37701690
105Rap1 signaling pathway_Homo sapiens_hsa040150.36884527
106Epstein-Barr virus infection_Homo sapiens_hsa051690.36096089
107HIF-1 signaling pathway_Homo sapiens_hsa040660.35850655
108Small cell lung cancer_Homo sapiens_hsa052220.31005889
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.30599945
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30207340
111cAMP signaling pathway_Homo sapiens_hsa040240.29408996
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29088400
113Phagosome_Homo sapiens_hsa041450.28877162
114Morphine addiction_Homo sapiens_hsa050320.27848953
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26762800
116Oxytocin signaling pathway_Homo sapiens_hsa049210.26398382

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