ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cerebellar granule cell differentiation (GO:0021707)	9.11311354
2	response to pheromone (GO:0019236)	8.88640867
3	cerebellar Purkinje cell differentiation (GO:0021702)	6.70859205
4	neuronal action potential propagation (GO:0019227)	6.69827124
5	sodium ion export (GO:0071436)	6.39842233
6	cell differentiation in hindbrain (GO:0021533)	6.31497049
7	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	6.30080345
8	cellular potassium ion homeostasis (GO:0030007)	6.27969069
9	locomotory exploration behavior (GO:0035641)	6.23103476
10	gamma-aminobutyric acid transport (GO:0015812)	6.13372002
11	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	5.82120730
12	ionotropic glutamate receptor signaling pathway (GO:0035235)	5.67839063
13	glutamate receptor signaling pathway (GO:0007215)	5.58235531
14	synaptic vesicle maturation (GO:0016188)	5.11928265
15	synaptic transmission, glutamatergic (GO:0035249)	5.08462142
16	neurotransmitter secretion (GO:0007269)	5.03576973
17	positive regulation of synapse maturation (GO:0090129)	5.01664561
18	regulation of short-term neuronal synaptic plasticity (GO:0048172)	4.90690618
19	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	4.88306738
20	short-term memory (GO:0007614)	4.86292478
21	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	4.81764619
22	regulation of female gonad development (GO:2000194)	4.75722967
23	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	4.74747978
24	gamma-aminobutyric acid signaling pathway (GO:0007214)	4.72791952
25	C4-dicarboxylate transport (GO:0015740)	4.71315674
26	vocalization behavior (GO:0071625)	4.68813178
27	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	4.61557794
28	neuromuscular process controlling posture (GO:0050884)	4.58575996
29	regulation of synaptic vesicle exocytosis (GO:2000300)	4.52521387
30	potassium ion import (GO:0010107)	4.50728383
31	parturition (GO:0007567)	4.48858783
32	neuron-neuron synaptic transmission (GO:0007270)	4.39605694
33	long-term memory (GO:0007616)	4.32243163
34	synaptic vesicle exocytosis (GO:0016079)	4.32152355
35	membrane depolarization during action potential (GO:0086010)	4.18208337
36	protein localization to synapse (GO:0035418)	4.17481974
37	multicellular organismal movement (GO:0050879)	4.16362583
38	musculoskeletal movement (GO:0050881)	4.16362583
39	metanephric epithelium development (GO:0072207)	4.14772519
40	glutamate secretion (GO:0014047)	4.11696910
41	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.11094618
42	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	4.09068615
43	cell communication by electrical coupling (GO:0010644)	4.06249133
44	cellular sodium ion homeostasis (GO:0006883)	4.02369120
45	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.93648057
46	positive regulation of male gonad development (GO:2000020)	3.93432584
47	neuromuscular process controlling balance (GO:0050885)	3.93191389
48	neurotransmitter transport (GO:0006836)	3.89606127
49	potassium ion homeostasis (GO:0055075)	3.86730225
50	regulation of synaptic vesicle transport (GO:1902803)	3.85400188
51	negative regulation of inclusion body assembly (GO:0090084)	3.83787556
52	regulation of synapse maturation (GO:0090128)	3.82251012
53	retinal cone cell development (GO:0046549)	3.81827659
54	exploration behavior (GO:0035640)	3.80669037
55	neuron cell-cell adhesion (GO:0007158)	3.80338563
56	calcium ion-dependent exocytosis (GO:0017156)	3.79752257
57	layer formation in cerebral cortex (GO:0021819)	3.73916147
58	negative regulation of hormone metabolic process (GO:0032351)	3.72436038
59	negative regulation of hormone biosynthetic process (GO:0032353)	3.72436038
60	regulation of neurotransmitter levels (GO:0001505)	3.71636548
61	transmission of nerve impulse (GO:0019226)	3.68498384
62	adult walking behavior (GO:0007628)	3.67062993
63	establishment of nucleus localization (GO:0040023)	3.56951935
64	regulation of excitatory postsynaptic membrane potential (GO:0060079)	3.55360370
65	postsynaptic membrane organization (GO:0001941)	3.55287773
66	long term synaptic depression (GO:0060292)	3.53366029
67	positive regulation of potassium ion transmembrane transport (GO:1901381)	3.52730718
68	glycine transport (GO:0015816)	3.42883761
69	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.42494563
70	regulation of voltage-gated calcium channel activity (GO:1901385)	3.42406117
71	positive regulation of membrane potential (GO:0045838)	3.42182475
72	positive regulation of dendritic spine development (GO:0060999)	3.41418206
73	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.41143635
74	retina layer formation (GO:0010842)	3.40999833
75	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	3.40714176
76	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	3.39689001
77	membrane depolarization (GO:0051899)	3.39467443
78	regulation of male gonad development (GO:2000018)	3.38239240
79	synaptic vesicle endocytosis (GO:0048488)	3.38233194
80	regulation of ARF protein signal transduction (GO:0032012)	3.33887548
81	prepulse inhibition (GO:0060134)	3.32121916
82	presynaptic membrane organization (GO:0097090)	3.31401417
83	regulation of neurotransmitter secretion (GO:0046928)	3.30349654
84	regulation of postsynaptic membrane potential (GO:0060078)	3.27499657
85	gonadal mesoderm development (GO:0007506)	3.24187168
86	dendrite morphogenesis (GO:0048813)	3.23073712
87	regulation of calcium ion-dependent exocytosis (GO:0017158)	3.20296906
88	regulation of glutamate receptor signaling pathway (GO:1900449)	3.20046592
89	acidic amino acid transport (GO:0015800)	3.19069557
90	behavioral response to nicotine (GO:0035095)	3.17911961
91	membrane repolarization (GO:0086009)	3.16692511
92	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.16608443
93	epithelial cell differentiation involved in kidney development (GO:0035850)	3.16163681
94	piRNA metabolic process (GO:0034587)	3.14200582
95	presynaptic membrane assembly (GO:0097105)	3.12643845
96	protein targeting to Golgi (GO:0000042)	3.12596443
97	regulation of long-term neuronal synaptic plasticity (GO:0048169)	3.12439091
98	regulation of meiosis I (GO:0060631)	3.10980894
99	L-glutamate transport (GO:0015813)	3.09464856
100	phosphatidylinositol dephosphorylation (GO:0046856)	3.08958278
101	regulation of dendritic spine morphogenesis (GO:0061001)	3.08340986
102	relaxation of cardiac muscle (GO:0055119)	3.08033295
103	membrane hyperpolarization (GO:0060081)	3.05879500
104	neurotransmitter-gated ion channel clustering (GO:0072578)	3.05877918
105	metanephric mesenchyme development (GO:0072075)	3.05680813
106	relaxation of smooth muscle (GO:0044557)	3.05213659
107	activation of protein kinase A activity (GO:0034199)	3.04309781
108	positive regulation of synapse assembly (GO:0051965)	3.03654684
109	detection of temperature stimulus involved in sensory perception of pain (GO:0050965)	3.03618573
110	detection of temperature stimulus involved in sensory perception (GO:0050961)	3.03618573
111	urinary tract smooth muscle contraction (GO:0014848)	3.03210372
112	neuromuscular process (GO:0050905)	3.02815191
113	negative regulation of microtubule polymerization (GO:0031115)	3.02417712
114	mechanosensory behavior (GO:0007638)	3.01770467
115	positive regulation of potassium ion transport (GO:0043268)	3.00382053
116	regulation of neurotransmitter transport (GO:0051588)	2.99951883
117	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.99281270
118	L-amino acid import (GO:0043092)	2.97473212
119	regulation of respiratory system process (GO:0044065)	2.97095739
120	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.95164685
121	detection of temperature stimulus (GO:0016048)	2.93316009
122	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.93094089
123	synapse assembly (GO:0007416)	2.92421670
124	auditory behavior (GO:0031223)	2.92368185
125	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.92286801
126	signal release (GO:0023061)	2.91922209
127	regulation of beta-amyloid formation (GO:1902003)	2.91882758
128	neurofilament cytoskeleton organization (GO:0060052)	2.91582104
129	chemosensory behavior (GO:0007635)	2.91474742
130	acrosome assembly (GO:0001675)	2.91254696
131	regulation of glucocorticoid secretion (GO:2000849)	2.89804950
132	regulation of cardiac muscle cell contraction (GO:0086004)	2.88656638
133	dendritic spine morphogenesis (GO:0060997)	2.85879129
134	dopamine biosynthetic process (GO:0042416)	2.84817137
135	cerebellar Purkinje cell layer development (GO:0021680)	2.83629098
136	positive regulation of heart growth (GO:0060421)	2.81427864
137	metanephric nephron tubule development (GO:0072234)	2.80538605
138	metanephric tubule development (GO:0072170)	2.80538605
139	regulation of glomerulus development (GO:0090192)	2.80376953
140	regulation of potassium ion transmembrane transporter activity (GO:1901016)	2.76325396
141	behavioral response to cocaine (GO:0048148)	2.72657216
142	regulation of potassium ion transmembrane transport (GO:1901379)	2.72510894
143	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.72430105
144	regulation of neuron projection regeneration (GO:0070570)	2.71577630

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.14302298
2	IKZF1_21737484_ChIP-ChIP_HCT116_Human	3.40943689
3	DROSHA_22980978_ChIP-Seq_HELA_Human	3.12658694
4	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	3.07139042
5	REST_21632747_ChIP-Seq_MESCs_Mouse	3.02991496
6	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.87856897
7	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.71333929
8	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.55095108
9	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.55095108
10	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.52627123
11	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.47622354
12	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.41934037
13	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.40959754
14	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.38018786
15	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.35388513
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.27254169
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.25209444
18	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.18561456
19	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.16364064
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.13494564
21	RARB_27405468_Chip-Seq_BRAIN_Mouse	2.10983747
22	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.07534037
23	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.02855850
24	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.00823210
25	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.98008908
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.93595346
27	VDR_22108803_ChIP-Seq_LS180_Human	1.87731746
28	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.86017168
29	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.82879903
30	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.81969050
31	GBX2_23144817_ChIP-Seq_PC3_Human	1.77684412
32	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.77498428
33	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.69749779
34	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.69585525
35	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.67155620
36	TAF15_26573619_Chip-Seq_HEK293_Human	1.62669642
37	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.62534241
38	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.61254393
39	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.60953100
40	AR_21572438_ChIP-Seq_LNCaP_Human	1.57954043
41	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.57211966
42	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.57076002
43	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.55573584
44	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.50755241
45	KDM2B_26808549_Chip-Seq_K562_Human	1.49434647
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.47629319
47	P300_19829295_ChIP-Seq_ESCs_Human	1.45306436
48	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.45259643
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.45170299
50	SMAD4_21799915_ChIP-Seq_A2780_Human	1.44144399
51	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43441659
52	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.37853762
53	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.36196389
54	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.34682939
55	FUS_26573619_Chip-Seq_HEK293_Human	1.34334688
56	AR_19668381_ChIP-Seq_PC3_Human	1.34178005
57	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32415508
58	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31910809
59	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.27790157
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25332791
61	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.24666962
62	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.22603217
63	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.20996103
64	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.20074811
65	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.18704925
66	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.18425087
67	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.18122798
68	IGF1R_20145208_ChIP-Seq_DFB_Human	1.17140160
69	STAT3_23295773_ChIP-Seq_U87_Human	1.15637553
70	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.11659915
71	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10837636
72	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.10503428
73	EWS_26573619_Chip-Seq_HEK293_Human	1.09688897
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08454819
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08340521
76	TCF4_23295773_ChIP-Seq_U87_Human	1.06318006
77	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.05831914
78	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.05547278
79	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.04592407
80	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04075015
81	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.03901193
82	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.03545584
83	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.03319595
84	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.03234034
85	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.02742622
86	BCAT_22108803_ChIP-Seq_LS180_Human	1.02712461
87	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.00663843
88	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.00663561
89	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00249183
90	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.00058457
91	ER_23166858_ChIP-Seq_MCF-7_Human	0.99798617
92	AR_25329375_ChIP-Seq_VCAP_Human	0.99176664
93	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.99080581
94	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.98718700
95	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.98399390
96	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.97900167
97	KLF4_19829295_ChIP-Seq_ESCs_Human	0.97611531
98	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.97147247
99	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95567717
100	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.95121519
101	CBP_20019798_ChIP-Seq_JUKART_Human	0.95121519
102	AHR_22903824_ChIP-Seq_MCF-7_Human	0.94806638
103	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.93436738
104	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.93091688
105	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.92754230
106	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.90544726
107	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.90386672
108	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.90343448
109	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.90132229
110	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.90132229
111	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.89081141
112	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.87442580
113	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	0.87393216
114	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.87009060
115	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	0.86762518
116	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	0.86643499
117	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.84848857
118	SMC4_20622854_ChIP-Seq_HELA_Human	0.84316678
119	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.83582157
120	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.83010284
121	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.82931222
122	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.82895976
123	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.82530900
124	TP53_16413492_ChIP-PET_HCT116_Human	0.82067304
125	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.81173466
126	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.81089783
127	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.80471719
128	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.80183494
129	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.80019349
130	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.79938674
131	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.79445598
132	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.77540090
133	RNF2_27304074_Chip-Seq_NSC_Mouse	0.77035407
134	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.76574769
135	TBL1_22424771_ChIP-Seq_293T_Human	0.76487133
136	RUNX2_22187159_ChIP-Seq_PCA_Human	0.76269390
137	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.76161451
138	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.75939317
139	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.75688000

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009046_muscle_twitch	5.92763950
2	MP0004859_abnormal_synaptic_plasticity	5.18384259
3	MP0008569_lethality_at_weaning	4.22305965
4	MP0003635_abnormal_synaptic_transmissio	3.97978580
5	MP0004145_abnormal_muscle_electrophysio	3.51679474
6	MP0002272_abnormal_nervous_system	3.19185689
7	MP0002064_seizures	3.08105004
8	MP0009745_abnormal_behavioral_response	3.05112990
9	MP0005410_abnormal_fertilization	2.89552738
10	MP0002067_abnormal_sensory_capabilities	2.80789624
11	MP0004270_analgesia	2.78379651
12	MP0005423_abnormal_somatic_nervous	2.65434260
13	MP0002734_abnormal_mechanical_nocicepti	2.65029640
14	MP0001440_abnormal_grooming_behavior	2.64282277
15	MP0001968_abnormal_touch/_nociception	2.62447348
16	MP0002063_abnormal_learning/memory/cond	2.61327579
17	MP0002572_abnormal_emotion/affect_behav	2.49928008
18	MP0002184_abnormal_innervation	2.40987227
19	MP0004147_increased_porphyrin_level	2.27776733
20	MP0002736_abnormal_nociception_after	2.26753186
21	MP0010386_abnormal_urinary_bladder	2.24132335
22	MP0001501_abnormal_sleep_pattern	2.20000237
23	MP0002735_abnormal_chemical_nociception	2.09268996
24	MP0003329_amyloid_beta_deposits	2.03254827
25	MP0006276_abnormal_autonomic_nervous	2.02952414
26	MP0004142_abnormal_muscle_tone	2.01661563
27	MP0001486_abnormal_startle_reflex	1.98952136
28	MP0003880_abnormal_central_pattern	1.96826678
29	MP0004885_abnormal_endolymph	1.93593604
30	MP0003632_abnormal_nervous_system	1.87149576
31	MP0004742_abnormal_vestibular_system	1.85047554
32	MP0004043_abnormal_pH_regulation	1.81705817
33	MP0001986_abnormal_taste_sensitivity	1.80500319
34	MP0002557_abnormal_social/conspecific_i	1.80455353
35	MP0002733_abnormal_thermal_nociception	1.77986439
36	MP0005386_behavior/neurological_phenoty	1.74834077
37	MP0004924_abnormal_behavior	1.74834077
38	MP0001970_abnormal_pain_threshold	1.67652996
39	MP0000955_abnormal_spinal_cord	1.64792340
40	MP0002066_abnormal_motor_capabilities/c	1.59909265
41	MP0003631_nervous_system_phenotype	1.50275355
42	MP0003633_abnormal_nervous_system	1.49654676
43	MP0003879_abnormal_hair_cell	1.42257437
44	MP0003698_abnormal_male_reproductive	1.38769382
45	MP0004811_abnormal_neuron_physiology	1.38645105
46	MP0008875_abnormal_xenobiotic_pharmacok	1.36110031
47	MP0003283_abnormal_digestive_organ	1.35917860
48	MP0000013_abnormal_adipose_tissue	1.35901856
49	MP0002909_abnormal_adrenal_gland	1.35140629
50	MP0004233_abnormal_muscle_weight	1.34139913
51	MP0001984_abnormal_olfaction	1.34132462
52	MP0001502_abnormal_circadian_rhythm	1.30598211
53	MP0003122_maternal_imprinting	1.27995729
54	MP0002882_abnormal_neuron_morphology	1.24657295
55	MP0002102_abnormal_ear_morphology	1.20613966
56	MP0003718_maternal_effect	1.20091384
57	MP0002152_abnormal_brain_morphology	1.19956247
58	MP0005083_abnormal_biliary_tract	1.19783326
59	MP0000566_synostosis	1.18791740
60	MP0003690_abnormal_glial_cell	1.18007869
61	MP0001188_hyperpigmentation	1.17672685
62	MP0000920_abnormal_myelination	1.17132726
63	MP0008872_abnormal_physiological_respon	1.15333792
64	MP0004858_abnormal_nervous_system	1.13849079
65	MP0004215_abnormal_myocardial_fiber	1.13738938
66	MP0003119_abnormal_digestive_system	1.12427695
67	MP0002229_neurodegeneration	1.10708001
68	MP0005646_abnormal_pituitary_gland	1.10660897
69	MP0003121_genomic_imprinting	1.09758011
70	MP0003646_muscle_fatigue	1.08594182
71	MP0005394_taste/olfaction_phenotype	1.07633073
72	MP0005499_abnormal_olfactory_system	1.07633073
73	MP0000778_abnormal_nervous_system	1.07283304
74	MP0009384_cardiac_valve_regurgitation	1.05980171
75	MP0005187_abnormal_penis_morphology	0.98584807
76	MP0006072_abnormal_retinal_apoptosis	0.96825857
77	MP0002089_abnormal_postnatal_growth/wei	0.96275291
78	MP0000604_amyloidosis	0.93334413
79	MP0003045_fibrosis	0.92833230
80	MP0003123_paternal_imprinting	0.91760319
81	MP0000639_abnormal_adrenal_gland	0.91611542
82	MP0002210_abnormal_sex_determination	0.90762388
83	MP0005551_abnormal_eye_electrophysiolog	0.90080720
84	MP0005623_abnormal_meninges_morphology	0.88234160
85	MP0003890_abnormal_embryonic-extraembry	0.87909657
86	MP0003137_abnormal_impulse_conducting	0.86880928
87	MP0008789_abnormal_olfactory_epithelium	0.84868826
88	MP0009379_abnormal_foot_pigmentation	0.84717929
89	MP0001929_abnormal_gametogenesis	0.83774153
90	MP0002161_abnormal_fertility/fecundity	0.83570119
91	MP0006035_abnormal_mitochondrial_morpho	0.83034188
92	MP0003567_abnormal_fetal_cardiomyocyte	0.82537097
93	MP0008877_abnormal_DNA_methylation	0.82491434
94	MP0004484_altered_response_of	0.81839591
95	MP0002653_abnormal_ependyma_morphology	0.81540958
96	MP0005409_darkened_coat_color	0.80987274
97	MP0009780_abnormal_chondrocyte_physiolo	0.80064339
98	MP0005389_reproductive_system_phenotype	0.79588385
99	MP0001905_abnormal_dopamine_level	0.77040974
100	MP0001299_abnormal_eye_distance/	0.76264324
101	MP0002069_abnormal_eating/drinking_beha	0.73492107
102	MP0001177_atelectasis	0.72774480
103	MP0000026_abnormal_inner_ear	0.72509557
104	MP0005645_abnormal_hypothalamus_physiol	0.72338617
105	MP0003942_abnormal_urinary_system	0.72205948
106	MP0001963_abnormal_hearing_physiology	0.71311058
107	MP0003866_abnormal_defecation	0.71082157
108	MP0003634_abnormal_glial_cell	0.69986593
109	MP0005620_abnormal_muscle_contractility	0.68950982
110	MP0000653_abnormal_sex_gland	0.67642489
111	MP0002877_abnormal_melanocyte_morpholog	0.67346131
112	MP0010769_abnormal_survival	0.67017897
113	MP0004036_abnormal_muscle_relaxation	0.66231419
114	MP0002638_abnormal_pupillary_reflex	0.64921242
115	MP0010768_mortality/aging	0.64797384
116	MP0003011_delayed_dark_adaptation	0.64667074
117	MP0001485_abnormal_pinna_reflex	0.63345723
118	MP0002160_abnormal_reproductive_system	0.63133827
119	MP0005253_abnormal_eye_physiology	0.62958727
120	MP0008961_abnormal_basal_metabolism	0.62909987
121	MP0000569_abnormal_digit_pigmentation	0.62736938
122	MP0003115_abnormal_respiratory_system	0.61720778
123	MP0008874_decreased_physiological_sensi	0.61422236
124	MP0002234_abnormal_pharynx_morphology	0.61037866
125	MP0004085_abnormal_heartbeat	0.60965175
126	MP0000747_muscle_weakness	0.60873300
127	MP0002752_abnormal_somatic_nervous	0.59996641
128	MP0002082_postnatal_lethality	0.59640691
129	MP0010770_preweaning_lethality	0.59640691
130	MP0003787_abnormal_imprinting	0.59388544
131	MP0008995_early_reproductive_senescence	0.58503042
132	MP0005535_abnormal_body_temperature	0.57216716
133	MP0000751_myopathy	0.57162680
134	MP0004084_abnormal_cardiac_muscle	0.56052838
135	MP0003956_abnormal_body_size	0.55920292

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Action tremor (HP:0002345)	7.97823746
2	Progressive cerebellar ataxia (HP:0002073)	7.58256187
3	Gaze-evoked nystagmus (HP:0000640)	6.28899725
4	Visual hallucinations (HP:0002367)	6.00035963
5	Dysmetric saccades (HP:0000641)	5.91973844
6	Scanning speech (HP:0002168)	5.58450239
7	Impaired smooth pursuit (HP:0007772)	5.53395195
8	Abnormality of ocular smooth pursuit (HP:0000617)	5.23813535
9	Focal motor seizures (HP:0011153)	5.06689393
10	Dysdiadochokinesis (HP:0002075)	5.02932744
11	Gonadal dysgenesis (HP:0000133)	4.94101159
12	Atonic seizures (HP:0010819)	4.79733501
13	Intention tremor (HP:0002080)	4.69519549
14	Degeneration of the lateral corticospinal tracts (HP:0002314)	4.67760578
15	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	4.67760578
16	Focal seizures (HP:0007359)	4.65379398
17	Myokymia (HP:0002411)	4.59322074
18	Hemiplegia (HP:0002301)	4.57671602
19	Abnormality of the lower motor neuron (HP:0002366)	4.46707391
20	Genetic anticipation (HP:0003743)	4.19144765
21	Tetraplegia (HP:0002445)	4.18848784
22	Febrile seizures (HP:0002373)	4.05528822
23	Dysmetria (HP:0001310)	3.98186197
24	Truncal ataxia (HP:0002078)	3.97014241
25	Hemiparesis (HP:0001269)	3.93374639
26	Broad-based gait (HP:0002136)	3.91474259
27	Testicular neoplasm (HP:0010788)	3.90471137
28	Postural tremor (HP:0002174)	3.82438519
29	Abnormality of saccadic eye movements (HP:0000570)	3.78442096
30	Anomalous pulmonary venous return (HP:0010772)	3.73221770
31	Diplopia (HP:0000651)	3.65817397
32	Abnormality of binocular vision (HP:0011514)	3.65817397
33	Horizontal nystagmus (HP:0000666)	3.62717668
34	Absence seizures (HP:0002121)	3.61091844
35	Hypoplastic left heart (HP:0004383)	3.60114965
36	Limb ataxia (HP:0002070)	3.56299700
37	Epileptic encephalopathy (HP:0200134)	3.50322477
38	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.38650313
39	Amyotrophic lateral sclerosis (HP:0007354)	3.32800423
40	Status epilepticus (HP:0002133)	3.22659518
41	True hermaphroditism (HP:0010459)	3.21539776
42	Abnormality of the pulmonary veins (HP:0011718)	3.20176477
43	Hypoplastic heart (HP:0001961)	3.19978395
44	Annular pancreas (HP:0001734)	3.10593012
45	Ventricular fibrillation (HP:0001663)	3.09775229
46	Poor eye contact (HP:0000817)	3.04376775
47	Dialeptic seizures (HP:0011146)	3.00638818
48	Bundle branch block (HP:0011710)	2.88154552
49	Depression (HP:0000716)	2.87639573
50	Gait ataxia (HP:0002066)	2.78685255
51	Impaired social interactions (HP:0000735)	2.78331969
52	Abnormal social behavior (HP:0012433)	2.78331969
53	Urinary bladder sphincter dysfunction (HP:0002839)	2.76685213
54	Generalized tonic-clonic seizures (HP:0002069)	2.76476587
55	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.74673438
56	Absent/shortened dynein arms (HP:0200106)	2.74673438
57	Agitation (HP:0000713)	2.66300840
58	Urinary urgency (HP:0000012)	2.64594211
59	Anxiety (HP:0000739)	2.64418001
60	Male infertility (HP:0003251)	2.64046122
61	Hyperventilation (HP:0002883)	2.58746397
62	Esotropia (HP:0000565)	2.55066805
63	Oligodactyly (hands) (HP:0001180)	2.52266718
64	Abnormal respiratory motile cilium physiology (HP:0012261)	2.50231801
65	Retinal dysplasia (HP:0007973)	2.45636652
66	Morphological abnormality of the pyramidal tract (HP:0002062)	2.45565282
67	Supranuclear gaze palsy (HP:0000605)	2.44169847
68	Abnormal eating behavior (HP:0100738)	2.43202519
69	Mesangial abnormality (HP:0001966)	2.42837883
70	Transposition of the great arteries (HP:0001669)	2.39171892
71	Abnormal connection of the cardiac segments (HP:0011545)	2.39171892
72	Abnormal ventriculo-arterial connection (HP:0011563)	2.39171892
73	Germ cell neoplasia (HP:0100728)	2.38470375
74	Male pseudohermaphroditism (HP:0000037)	2.38199792
75	Myotonia (HP:0002486)	2.37681050
76	Abnormality of the corticospinal tract (HP:0002492)	2.37013019
77	Hand muscle atrophy (HP:0009130)	2.36721965
78	Abnormal respiratory motile cilium morphology (HP:0005938)	2.36148365
79	Lower limb asymmetry (HP:0100559)	2.36073115
80	Neuronal loss in central nervous system (HP:0002529)	2.32954187
81	Spastic tetraparesis (HP:0001285)	2.31402492
82	Abnormal sex determination (HP:0012244)	2.29692762
83	Sex reversal (HP:0012245)	2.29692762
84	Spinal canal stenosis (HP:0003416)	2.28600129
85	Postural instability (HP:0002172)	2.28430525
86	Abnormality of the labia minora (HP:0012880)	2.27079976
87	Mutism (HP:0002300)	2.24173639
88	Chronic hepatic failure (HP:0100626)	2.22934530
89	Pointed chin (HP:0000307)	2.17541481
90	Slow progression (HP:0003677)	2.17277763
91	Spastic gait (HP:0002064)	2.15155963
92	Amblyopia (HP:0000646)	2.13440258
93	Osteomalacia (HP:0002749)	2.11354703
94	Lower limb muscle weakness (HP:0007340)	2.06528098
95	Chronic bronchitis (HP:0004469)	2.05768424
96	Impaired vibration sensation in the lower limbs (HP:0002166)	2.03601536
97	Psychosis (HP:0000709)	2.03021381
98	Stereotypic behavior (HP:0000733)	2.01729032
99	Female pseudohermaphroditism (HP:0010458)	2.01077894
100	Polyphagia (HP:0002591)	1.98195132
101	Type II lissencephaly (HP:0007260)	1.97829829
102	Neoplasm of the heart (HP:0100544)	1.97089832
103	Epileptiform EEG discharges (HP:0011182)	1.96350818
104	Split foot (HP:0001839)	1.95111964
105	Papilledema (HP:0001085)	1.95111311
106	Clonus (HP:0002169)	1.92376098
107	Rhinitis (HP:0012384)	1.90941904
108	Focal dystonia (HP:0004373)	1.90662623
109	Abnormal ciliary motility (HP:0012262)	1.89678796
110	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.88521093
111	Insomnia (HP:0100785)	1.86384253
112	Gait imbalance (HP:0002141)	1.84600896
113	Akinesia (HP:0002304)	1.84075223
114	Limb dystonia (HP:0002451)	1.83553927
115	Nonprogressive disorder (HP:0003680)	1.81532266
116	EEG with generalized epileptiform discharges (HP:0011198)	1.81171878
117	Confusion (HP:0001289)	1.79810077
118	Cerebellar atrophy (HP:0001272)	1.79355894
119	Upper limb amyotrophy (HP:0009129)	1.78401245
120	Distal upper limb amyotrophy (HP:0007149)	1.78401245
121	Abnormality of midbrain morphology (HP:0002418)	1.78299808
122	Molar tooth sign on MRI (HP:0002419)	1.78299808
123	Complete atrioventricular canal defect (HP:0001674)	1.76196971
124	Upper motor neuron abnormality (HP:0002127)	1.75750458
125	Infertility (HP:0000789)	1.75159608
126	Hypoplasia of the uterus (HP:0000013)	1.73628762
127	Paraplegia (HP:0010550)	1.70810694
128	Pheochromocytoma (HP:0002666)	1.70728189
129	Broad metatarsal (HP:0001783)	1.70589180
130	Spastic paraplegia (HP:0001258)	1.70314935
131	Aqueductal stenosis (HP:0002410)	1.69756497
132	Torticollis (HP:0000473)	1.69537764
133	Fetal akinesia sequence (HP:0001989)	1.67037662
134	Impaired vibratory sensation (HP:0002495)	1.66704498
135	Progressive inability to walk (HP:0002505)	1.66637231
136	Oligodactyly (HP:0012165)	1.63574880
137	Drooling (HP:0002307)	1.62755056
138	Excessive salivation (HP:0003781)	1.62755056
139	Hypoplastic nipples (HP:0002557)	1.62499937
140	Dysarthria (HP:0001260)	1.62277398
141	Bradykinesia (HP:0002067)	1.61968690
142	Incomplete penetrance (HP:0003829)	1.59652366
143	Ankle clonus (HP:0011448)	1.59494198
144	Shallow orbits (HP:0000586)	1.59220300
145	Spastic tetraplegia (HP:0002510)	1.57084074
146	Abnormal respiratory epithelium morphology (HP:0012253)	1.56047593

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CAMKK2	5.44400865
2	RIPK1	4.45300198
3	WNK1	3.45391310
4	CAMKK1	3.17364448
5	STK38	2.76122803
6	NTRK3	2.75821636
7	ARAF	2.60438256
8	MAP3K4	2.53210804
9	EPHA4	2.37074527
10	MINK1	2.34205568
11	TIE1	2.27874610
12	CDK19	2.26291782
13	MAP3K9	2.21312118
14	NTRK2	2.19738986
15	PAK6	2.04882224
16	MAP2K4	1.85917641
17	PDK3	1.81385059
18	PDK4	1.81385059
19	PNCK	1.78911302
20	DAPK2	1.77864202
21	CASK	1.76150842
22	MARK1	1.75662419
23	MAP2K7	1.72918708
24	PRPF4B	1.63708732
25	MAP3K13	1.57844792
26	PRKD3	1.56733043
27	PRKCG	1.50702250
28	TYRO3	1.49182696
29	PTK6	1.36259096
30	ALK	1.33364538
31	PINK1	1.32851062
32	RIPK4	1.30502338
33	ACVR1B	1.29936934
34	STK11	1.24586114
35	OXSR1	1.21309421
36	MAP3K12	1.19708926
37	CAMK1	1.17997975
38	MAPK15	1.17878297
39	PRKCH	1.16995274
40	SGK2	1.16977232
41	SIK2	1.13176178
42	SGK494	1.12469697
43	SGK223	1.12469697
44	CAMK4	1.12343616
45	LATS2	1.11755937
46	SGK3	1.10077215
47	EPHB1	1.08044378
48	MAPKAPK5	1.05965128
49	TRIM28	1.04871662
50	CDK15	1.04744310
51	PDK1	1.03297767
52	UHMK1	1.02330382
53	CDK18	1.00934530
54	CDK5	0.98146835
55	CAMK1G	0.97271570
56	CAMK2G	0.96060499
57	ICK	0.96050971
58	PKN1	0.95658643
59	TESK1	0.94295418
60	STK38L	0.92987088
61	CDK11A	0.91834442
62	CSNK1G1	0.91278035
63	GRK5	0.91124633
64	BMPR1B	0.89295106
65	CSNK1G2	0.88868162
66	SCYL2	0.87166027
67	PDK2	0.86979168
68	CDC42BPA	0.85807314
69	CDK14	0.83594292
70	STK24	0.82959381
71	TNIK	0.80240963
72	DYRK1A	0.79446575
73	HIPK2	0.79302694
74	PHKG2	0.77200286
75	PHKG1	0.77200286
76	RET	0.76519419
77	GRK7	0.75650654
78	PDPK1	0.74932498
79	PRKG1	0.74578865
80	NTRK1	0.74395975
81	PTK2	0.74228215
82	PLK4	0.73617560
83	LMTK2	0.72373444
84	PAK3	0.70764661
85	RAF1	0.69258822
86	CSNK1G3	0.69228077
87	CDK3	0.68271770
88	GRK1	0.66992635
89	MAPK13	0.66842274
90	CSNK1A1L	0.66579881
91	MARK2	0.66309277
92	CAMK2B	0.64185264
93	PRKCE	0.61887243
94	TRIB3	0.61850321
95	ROCK2	0.61714711
96	PTK2B	0.61131090
97	CAMK2D	0.60586251
98	BRAF	0.59831444
99	RPS6KA3	0.56843558
100	CSNK1A1	0.55167442
101	FRK	0.54890587
102	CSNK1D	0.54842474
103	CAMK2A	0.54699524
104	PRKDC	0.53947176
105	DAPK1	0.52419884
106	KSR1	0.52332390
107	SGK1	0.51995774
108	FYN	0.51886620
109	RPS6KB1	0.51056458
110	STK39	0.50927199
111	MET	0.50763327
112	KSR2	0.50431925
113	PLK2	0.49577305
114	NEK6	0.48675333
115	AURKA	0.47637034
116	ERBB3	0.47247848
117	TTK	0.46791847
118	MAP3K2	0.43431861
119	DYRK3	0.43054452
120	PRKAA1	0.41986516
121	MOS	0.40929287
122	MAP2K1	0.40377225
123	WNK4	0.40089484
124	PRKCZ	0.39274526
125	PRKACA	0.39113211
126	NEK1	0.38446616
127	PRKACB	0.38431581
128	TGFBR1	0.37016939
129	SRC	0.36849394
130	MAPK8	0.36542991
131	MAPK10	0.35640033
132	TAF1	0.35626944
133	PRKACG	0.35547209
134	CSNK1E	0.33116396
135	NEK2	0.32520949
136	DYRK1B	0.31683103
137	PRKCA	0.31173736
138	TNK2	0.30825062
139	EEF2K	0.30377997

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.46298283
2	Long-term potentiation_Homo sapiens_hsa04720	3.23927192
3	Glutamatergic synapse_Homo sapiens_hsa04724	3.22549830
4	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.91509560
5	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.79996881
6	Circadian entrainment_Homo sapiens_hsa04713	2.79431365
7	Long-term depression_Homo sapiens_hsa04730	2.78054804
8	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.71357769
9	Taste transduction_Homo sapiens_hsa04742	2.59907656
10	GABAergic synapse_Homo sapiens_hsa04727	2.58133040
11	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.39240873
12	Salivary secretion_Homo sapiens_hsa04970	2.35811605
13	Amphetamine addiction_Homo sapiens_hsa05031	2.28915931
14	Morphine addiction_Homo sapiens_hsa05032	2.27185513
15	Gastric acid secretion_Homo sapiens_hsa04971	2.03635373
16	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	2.03563836
17	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.93046441
18	Insulin secretion_Homo sapiens_hsa04911	1.90241442
19	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.89745293
20	Dopaminergic synapse_Homo sapiens_hsa04728	1.81360553
21	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.77523299
22	Type II diabetes mellitus_Homo sapiens_hsa04930	1.66987114
23	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.62539997
24	Pancreatic secretion_Homo sapiens_hsa04972	1.57792371
25	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.57609137
26	Olfactory transduction_Homo sapiens_hsa04740	1.51827004
27	Cholinergic synapse_Homo sapiens_hsa04725	1.51443105
28	Calcium signaling pathway_Homo sapiens_hsa04020	1.50348799
29	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.44664288
30	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.44349300
31	Estrogen signaling pathway_Homo sapiens_hsa04915	1.40577881
32	Renin secretion_Homo sapiens_hsa04924	1.33979655
33	cAMP signaling pathway_Homo sapiens_hsa04024	1.29108118
34	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.18458720
35	GnRH signaling pathway_Homo sapiens_hsa04912	1.15546766
36	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.15441136
37	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.14587688
38	Cardiac muscle contraction_Homo sapiens_hsa04260	1.12783659
39	Gap junction_Homo sapiens_hsa04540	1.11887637
40	Oocyte meiosis_Homo sapiens_hsa04114	1.07297694
41	Serotonergic synapse_Homo sapiens_hsa04726	1.06609159
42	Bile secretion_Homo sapiens_hsa04976	1.01098169
43	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.99895206
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.97462743
45	Cocaine addiction_Homo sapiens_hsa05030	0.95274980
46	Nitrogen metabolism_Homo sapiens_hsa00910	0.91838202
47	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.91560358
48	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.89816122
49	Glucagon signaling pathway_Homo sapiens_hsa04922	0.80613707
50	Alzheimers disease_Homo sapiens_hsa05010	0.79324902
51	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.76487310
52	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74528212
53	Circadian rhythm_Homo sapiens_hsa04710	0.74108497
54	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.74095783
55	Phototransduction_Homo sapiens_hsa04744	0.69441865
56	Huntingtons disease_Homo sapiens_hsa05016	0.67649470
57	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.65954584
58	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.64457816
59	Melanogenesis_Homo sapiens_hsa04916	0.64392325
60	Mineral absorption_Homo sapiens_hsa04978	0.64223730
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.63191380
62	Choline metabolism in cancer_Homo sapiens_hsa05231	0.63026684
63	Basal transcription factors_Homo sapiens_hsa03022	0.62120185
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.61721830
65	mTOR signaling pathway_Homo sapiens_hsa04150	0.60568692
66	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.60531704
67	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.59567531
68	ABC transporters_Homo sapiens_hsa02010	0.58733041
69	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.57312139
70	Oxidative phosphorylation_Homo sapiens_hsa00190	0.56076536
71	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.55016477
72	Hippo signaling pathway_Homo sapiens_hsa04390	0.54872028
73	Fatty acid elongation_Homo sapiens_hsa00062	0.54836262
74	Glioma_Homo sapiens_hsa05214	0.54255940
75	MAPK signaling pathway_Homo sapiens_hsa04010	0.53214625
76	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.52821225
77	Ras signaling pathway_Homo sapiens_hsa04014	0.52617345
78	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.49720096
79	ErbB signaling pathway_Homo sapiens_hsa04012	0.49329691
80	VEGF signaling pathway_Homo sapiens_hsa04370	0.46792757
81	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.46087865
82	Regulation of autophagy_Homo sapiens_hsa04140	0.46009430
83	Wnt signaling pathway_Homo sapiens_hsa04310	0.45942125
84	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.43478839
85	Parkinsons disease_Homo sapiens_hsa05012	0.42532007
86	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.41580498
87	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.41521311
88	Endocytosis_Homo sapiens_hsa04144	0.38307022
89	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.35997016
90	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.35688176
91	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.34896099
92	Tight junction_Homo sapiens_hsa04530	0.34500606
93	Linoleic acid metabolism_Homo sapiens_hsa00591	0.32506329
94	Protein digestion and absorption_Homo sapiens_hsa04974	0.31875367
95	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.30428983
96	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30328650
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.29955559
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.29713496
99	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.28571539
100	Caffeine metabolism_Homo sapiens_hsa00232	0.28306425
101	Alcoholism_Homo sapiens_hsa05034	0.28080143
102	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.27952695
103	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.27616191
104	Ether lipid metabolism_Homo sapiens_hsa00565	0.27408743
105	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.27322878
106	Proteoglycans in cancer_Homo sapiens_hsa05205	0.26615608
107	Butanoate metabolism_Homo sapiens_hsa00650	0.25403116
108	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.24780607
109	Axon guidance_Homo sapiens_hsa04360	0.24171017
110	Histidine metabolism_Homo sapiens_hsa00340	0.23708484
111	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.23179686
112	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.22260966
113	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.22084362
114	Platelet activation_Homo sapiens_hsa04611	0.22024981
115	Endometrial cancer_Homo sapiens_hsa05213	0.20317802
116	Vibrio cholerae infection_Homo sapiens_hsa05110	0.20088178
117	AMPK signaling pathway_Homo sapiens_hsa04152	0.20011291
118	Rap1 signaling pathway_Homo sapiens_hsa04015	0.17952626
119	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.17858183
120	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.17546552
121	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.17367020
122	Chemokine signaling pathway_Homo sapiens_hsa04062	0.16265630
123	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.16105334
124	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.15628725
125	Non-small cell lung cancer_Homo sapiens_hsa05223	0.15492805

ARHGEF33

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »