ARHGEF34P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.32882938
2hemidesmosome assembly (GO:0031581)6.98984651
3bundle of His cell to Purkinje myocyte communication (GO:0086069)6.66622086
4regulation of water loss via skin (GO:0033561)6.27305022
5establishment of skin barrier (GO:0061436)6.01987451
6multicellular organismal water homeostasis (GO:0050891)4.79178381
7epithelial cell-cell adhesion (GO:0090136)4.40008617
8cell-substrate junction assembly (GO:0007044)4.23418175
9keratinization (GO:0031424)4.20056323
10water homeostasis (GO:0030104)3.93827875
11keratinocyte proliferation (GO:0043616)3.92162334
12skin morphogenesis (GO:0043589)3.82605344
13cytoskeletal anchoring at plasma membrane (GO:0007016)3.81908040
14activation of Rac GTPase activity (GO:0032863)3.80367185
15regulation of cholesterol homeostasis (GO:2000188)3.68187048
16cellular response to epidermal growth factor stimulus (GO:0071364)3.61290878
17surfactant homeostasis (GO:0043129)3.54178641
18planar cell polarity pathway involved in neural tube closure (GO:0090179)3.53769781
19branching involved in mammary gland duct morphogenesis (GO:0060444)3.51866608
20negative regulation of keratinocyte proliferation (GO:0010839)3.51480697
21adherens junction assembly (GO:0034333)3.51283924
22regulation of transforming growth factor beta1 production (GO:0032908)3.48898730
23atrioventricular valve morphogenesis (GO:0003181)3.48113986
24regulation of G0 to G1 transition (GO:0070316)3.37176348
25focal adhesion assembly (GO:0048041)3.35875638
26cell-substrate adherens junction assembly (GO:0007045)3.35875638
27endothelial cell chemotaxis (GO:0035767)3.33516413
28regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.32348958
29keratinocyte differentiation (GO:0030216)3.31058180
30COPI coating of Golgi vesicle (GO:0048205)3.27822415
31Golgi transport vesicle coating (GO:0048200)3.27822415
32intestinal epithelial cell development (GO:0060576)3.25750431
33regulation of podosome assembly (GO:0071801)3.20504754
34gap junction assembly (GO:0016264)3.20122972
35semaphorin-plexin signaling pathway (GO:0071526)3.15970327
36positive regulation of epidermal cell differentiation (GO:0045606)3.14411292
37positive regulation of Cdc42 GTPase activity (GO:0043089)3.07755951
38receptor catabolic process (GO:0032801)3.07231193
39epidermal cell differentiation (GO:0009913)3.03610776
40apoptotic process involved in morphogenesis (GO:0060561)3.00964142
41regulation of glucose import in response to insulin stimulus (GO:2001273)2.98906350
42regulation of endothelial cell chemotaxis (GO:2001026)2.97116388
43maintenance of gastrointestinal epithelium (GO:0030277)2.95988782
44response to epidermal growth factor (GO:0070849)2.94615437
45polarized epithelial cell differentiation (GO:0030859)2.93994546
46establishment of apical/basal cell polarity (GO:0035089)2.93166282
47insulin-like growth factor receptor signaling pathway (GO:0048009)2.93103444
48epithelial cell differentiation involved in prostate gland development (GO:0060742)2.92541959
49positive regulation of keratinocyte differentiation (GO:0045618)2.92490101
50glomerular visceral epithelial cell development (GO:0072015)2.91560436
51chemical homeostasis within a tissue (GO:0048875)2.91369691
52O-glycan processing (GO:0016266)2.87187619
53maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.80628786
54regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.79307019
55positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.78567435
56regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.77892105
57urea cycle (GO:0000050)2.72299022
58cell-cell junction assembly (GO:0007043)2.72154709
59negative regulation of fatty acid transport (GO:2000192)2.71942133
60tight junction assembly (GO:0070830)2.68737902
61protein retention in ER lumen (GO:0006621)2.67963373
62hypotonic response (GO:0006971)2.65799756
63trophectodermal cell differentiation (GO:0001829)2.64189057
64dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.63151757
65epithelial structure maintenance (GO:0010669)2.62355728
66mesodermal cell differentiation (GO:0048333)2.61056580
67negative regulation of cell fate specification (GO:0009996)2.60108398
68embryonic eye morphogenesis (GO:0048048)2.59787692
69regulation of keratinocyte proliferation (GO:0010837)2.58939587
70regulation of transforming growth factor beta2 production (GO:0032909)2.58664099
71branching involved in salivary gland morphogenesis (GO:0060445)2.57980038
72glomerular epithelial cell development (GO:0072310)2.56705456
73urea metabolic process (GO:0019627)2.53526451
74negative regulation of chondrocyte differentiation (GO:0032331)2.52400034
75morphogenesis of embryonic epithelium (GO:0016331)2.51926478
76Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.51369623
77regulation of keratinocyte differentiation (GO:0045616)2.51298598
78nuclear pore complex assembly (GO:0051292)2.50416679
79lung epithelium development (GO:0060428)2.50276633
80cell junction assembly (GO:0034329)2.50246319
81apical protein localization (GO:0045176)2.49399237
82hippo signaling (GO:0035329)2.49134880
83regulation of cardioblast differentiation (GO:0051890)2.48449355
84regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.48188489
85bone remodeling (GO:0046849)2.47950512
86histone H3-K36 demethylation (GO:0070544)2.47775486
87protein localization to endosome (GO:0036010)2.47473097
88regulation of fatty acid beta-oxidation (GO:0031998)2.47121480
89embryonic process involved in female pregnancy (GO:0060136)2.47069190
90positive regulation of osteoblast proliferation (GO:0033690)2.47006105
91endothelial cell morphogenesis (GO:0001886)2.46979602
92epidermis development (GO:0008544)2.43575767
93regulation of establishment of planar polarity (GO:0090175)2.42783042
94positive regulation of epidermis development (GO:0045684)2.42489274
95retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.41472056
96collecting duct development (GO:0072044)2.40843229
97cell junction organization (GO:0034330)2.37865969
98negative regulation of myotube differentiation (GO:0010832)2.37465769
99neural tube development (GO:0021915)2.36188120
100positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.36161544

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.96308008
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.10036385
3ESR2_21235772_ChIP-Seq_MCF-7_Human3.06763895
4ZNF263_19887448_ChIP-Seq_K562_Human2.88924404
5TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.82741875
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.78298404
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.75009235
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.71381542
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.62569724
10RACK7_27058665_Chip-Seq_MCF-7_Human2.57790925
11KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.52384771
12KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.20002765
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12263678
14SOX2_27498859_Chip-Seq_STOMACH_Mouse2.10516862
15SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.07490292
16SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.07490292
17RUNX1_27514584_Chip-Seq_MCF-7_Human2.02634432
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.01114924
19CDX2_20551321_ChIP-Seq_CACO-2_Human2.00829434
20SOX9_24532713_ChIP-Seq_HFSC_Mouse1.97935882
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.94517469
22CLOCK_20551151_ChIP-Seq_293T_Human1.91665359
23GATA6_25053715_ChIP-Seq_YYC3_Human1.86212556
24ATF3_27146783_Chip-Seq_COLON_Human1.83302663
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.82379965
26P63_26484246_Chip-Seq_KERATINOCYTES_Human1.80521531
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78161845
28LXR_22292898_ChIP-Seq_THP-1_Human1.77984898
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.76073988
30AR_21909140_ChIP-Seq_LNCAP_Human1.71411286
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67570234
32TCF7_22412390_ChIP-Seq_EML_Mouse1.67129658
33P300_27058665_Chip-Seq_ZR-75-30cells_Human1.66831219
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66152646
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.65900606
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65340404
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.63620951
38SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.61481791
39ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.60983353
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.58593089
41KDM2B_26808549_Chip-Seq_K562_Human1.56935354
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.54816812
43KLF5_25053715_ChIP-Seq_YYC3_Human1.53332630
44UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51589825
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.47161385
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45664119
47MYC_22102868_ChIP-Seq_BL_Human1.44249140
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43849472
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42307685
50UBF1/2_26484160_Chip-Seq_HMECs_Human1.40290116
51CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.39826286
52TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39200331
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.37533763
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.37118350
55CREB1_26743006_Chip-Seq_LNCaP_Human1.36066173
56PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30244838
57CHD1_26751641_Chip-Seq_LNCaP_Human1.30160793
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29753613
59SOX2_20726797_ChIP-Seq_SW620_Human1.28145661
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.26348940
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26023471
62RXR_22158963_ChIP-Seq_LIVER_Mouse1.23780401
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23605469
64ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21502251
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21185062
66SMC4_20622854_ChIP-Seq_HELA_Human1.19446944
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19164584
68E2F7_22180533_ChIP-Seq_HELA_Human1.19003069
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18613592
70GATA3_24758297_ChIP-Seq_MCF-7_Human1.18570882
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16760317
72FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16080786
73KDM2B_26808549_Chip-Seq_DND41_Human1.15745321
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15378033
75TP63_22573176_ChIP-Seq_HFKS_Human1.14700779
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14379891
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13799531
78GATA4_25053715_ChIP-Seq_YYC3_Human1.13625586
79TRIM28_21343339_ChIP-Seq_HEK293_Human1.12451047
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10627153
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08640551
82TP53_22127205_ChIP-Seq_IMR90_Human1.07339748
83NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05513647
84FOXA2_19822575_ChIP-Seq_HepG2_Human1.05080433
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04464275
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04463582
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01305612
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99827169
89AHR_22903824_ChIP-Seq_MCF-7_Human0.99416121
90EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99104047
91STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97946914
92LXR_22158963_ChIP-Seq_LIVER_Mouse0.97092222
93P68_20966046_ChIP-Seq_HELA_Human0.96858860
94VDR_21846776_ChIP-Seq_THP-1_Human0.96264972
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96200128
96FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93346010
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92838556
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92147339
99KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91798289
100TBX20_22328084_ChIP-Seq_HEART_Mouse0.91077132

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.76596555
2MP0002796_impaired_skin_barrier4.34631488
3MP0003705_abnormal_hypodermis_morpholog4.07838271
4MP0000579_abnormal_nail_morphology3.51106664
5MP0000566_synostosis3.43481934
6MP0004264_abnormal_extraembryonic_tissu2.94881477
7MP0005275_abnormal_skin_tensile2.90756312
8MP0003566_abnormal_cell_adhesion2.87432625
9MP0005501_abnormal_skin_physiology2.81789509
10MP0005076_abnormal_cell_differentiation2.59465359
11MP0010352_gastrointestinal_tract_polyps2.59423197
12MP0003941_abnormal_skin_development2.54912101
13MP0003453_abnormal_keratinocyte_physiol2.48028755
14MP0002060_abnormal_skin_morphology2.44476441
15MP0010678_abnormal_skin_adnexa2.37893215
16MP0001849_ear_inflammation2.14619310
17MP0001216_abnormal_epidermal_layer2.14138815
18MP0002098_abnormal_vibrissa_morphology2.14057412
19MP0000537_abnormal_urethra_morphology2.00593749
20MP0000762_abnormal_tongue_morphology1.94835118
21MP0005409_darkened_coat_color1.92632631
22MP0000467_abnormal_esophagus_morphology1.92020088
23MP0000383_abnormal_hair_follicle1.80075842
24MP0005257_abnormal_intraocular_pressure1.77753533
25MP0002254_reproductive_system_inflammat1.75420646
26MP0004782_abnormal_surfactant_physiolog1.75400491
27MP0004272_abnormal_basement_membrane1.73218190
28MP0005023_abnormal_wound_healing1.67409396
29MP0010771_integument_phenotype1.61018548
30MP0004858_abnormal_nervous_system1.60114486
31MP0000377_abnormal_hair_follicle1.59295580
32MP0004185_abnormal_adipocyte_glucose1.50863953
33MP0003091_abnormal_cell_migration1.50152119
34MP0004947_skin_inflammation1.44058947
35MP0000678_abnormal_parathyroid_gland1.42676308
36MP0001666_abnormal_nutrient_absorption1.42056875
37MP0002877_abnormal_melanocyte_morpholog1.40350288
38MP0008438_abnormal_cutaneous_collagen1.34352805
39MP0000627_abnormal_mammary_gland1.21250351
40MP0009931_abnormal_skin_appearance1.18528305
41MP0005666_abnormal_adipose_tissue1.17943614
42MP0010030_abnormal_orbit_morphology1.15691665
43MP0000003_abnormal_adipose_tissue1.12939439
44MP0002249_abnormal_larynx_morphology1.06979916
45MP0005375_adipose_tissue_phenotype1.05941202
46MP0005670_abnormal_white_adipose1.03602862
47MP0000462_abnormal_digestive_system0.99589390
48MP0002896_abnormal_bone_mineralization0.98750932
49MP0005451_abnormal_body_composition0.98144646
50MP0000477_abnormal_intestine_morphology0.93713433
51MP0001730_embryonic_growth_arrest0.92549158
52MP0003868_abnormal_feces_composition0.90173952
53MP0004043_abnormal_pH_regulation0.88828893
54MP0003693_abnormal_embryo_hatching0.86815256
55MP0005360_urolithiasis0.86300730
56MP0001348_abnormal_lacrimal_gland0.86006581
57MP0009053_abnormal_anal_canal0.83872546
58MP0009672_abnormal_birth_weight0.83287720
59MP0000432_abnormal_head_morphology0.83003825
60MP0004233_abnormal_muscle_weight0.82959947
61MP0005621_abnormal_cell_physiology0.82907692
62MP0005083_abnormal_biliary_tract0.82747126
63MP0002086_abnormal_extraembryonic_tissu0.82273289
64MP0001765_abnormal_ion_homeostasis0.81190423
65MP0001881_abnormal_mammary_gland0.80812002
66MP0003045_fibrosis0.80345304
67MP0003315_abnormal_perineum_morphology0.79406768
68MP0002697_abnormal_eye_size0.78521316
69MP0002166_altered_tumor_susceptibility0.77727267
70MP0000470_abnormal_stomach_morphology0.77423491
71MP0003191_abnormal_cellular_cholesterol0.77194066
72MP0004381_abnormal_hair_follicle0.76696657
73MP0001243_abnormal_dermal_layer0.75930827
74MP0003984_embryonic_growth_retardation0.75190326
75MP0002111_abnormal_tail_morphology0.74564763
76MP0003115_abnormal_respiratory_system0.72416553
77MP0004197_abnormal_fetal_growth/weight/0.70460426
78MP0002088_abnormal_embryonic_growth/wei0.70098505
79MP0000733_abnormal_muscle_development0.69793345
80MP0000465_gastrointestinal_hemorrhage0.68217651
81MP0009780_abnormal_chondrocyte_physiolo0.68184317
82MP0001664_abnormal_digestion0.67196897
83MP0001873_stomach_inflammation0.66810629
84MP0001672_abnormal_embryogenesis/_devel0.66581613
85MP0005380_embryogenesis_phenotype0.66581613
86MP0000858_altered_metastatic_potential0.66457124
87MP0001191_abnormal_skin_condition0.66237985
88MP0002006_tumorigenesis0.64454360
89MP0004019_abnormal_vitamin_homeostasis0.64367230
90MP0001661_extended_life_span0.63335225
91MP0000367_abnormal_coat/_hair0.63046122
92MP0000350_abnormal_cell_proliferation0.60944287
93MP0000013_abnormal_adipose_tissue0.60613079
94MP0002089_abnormal_postnatal_growth/wei0.59413976
95MP0002084_abnormal_developmental_patter0.59399553
96MP0004957_abnormal_blastocyst_morpholog0.58536138
97MP0005365_abnormal_bile_salt0.57367993
98MP0000538_abnormal_urinary_bladder0.56818226
99MP0002925_abnormal_cardiovascular_devel0.56295229
100MP0005508_abnormal_skeleton_morphology0.56227959

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.16112644
2Pili torti (HP:0003777)4.11244969
3Milia (HP:0001056)4.00148767
4Plantar hyperkeratosis (HP:0007556)3.56103844
5Abnormality of nail color (HP:0100643)3.54947955
6Atrophic scars (HP:0001075)3.50132979
7Broad face (HP:0000283)3.42595241
8Advanced eruption of teeth (HP:0006288)3.28317111
9Lip pit (HP:0100267)3.26845154
10Alopecia of scalp (HP:0002293)3.20351069
11Abnormal hair laboratory examination (HP:0003328)3.11516057
12Hyperacusis (HP:0010780)3.09645317
13Natal tooth (HP:0000695)3.09618418
14Fragile skin (HP:0001030)3.04092738
15Palmoplantar hyperkeratosis (HP:0000972)3.00582801
16Hyperactive renin-angiotensin system (HP:0000841)2.97468539
17Fragile nails (HP:0001808)2.90361864
18Flat acetabular roof (HP:0003180)2.87492867
19Palmar hyperkeratosis (HP:0010765)2.79949151
20Thin bony cortex (HP:0002753)2.78840311
21Abnormality of the salivary glands (HP:0010286)2.76850777
22Onycholysis (HP:0001806)2.73733118
23Short nail (HP:0001799)2.70286953
24Abnormality of the distal phalanx of the thumb (HP:0009617)2.69258062
25Abnormality of the fingertips (HP:0001211)2.67038225
26Distal lower limb amyotrophy (HP:0008944)2.63671247
27Thick nail (HP:0001805)2.60478194
28Selective tooth agenesis (HP:0001592)2.53207694
29Obstructive sleep apnea (HP:0002870)2.52612223
30Pterygium (HP:0001059)2.52362547
31Ankyloglossia (HP:0010296)2.48607486
32Hypotrichosis (HP:0001006)2.46284917
33Nail dystrophy (HP:0008404)2.46245461
34Hypoplasia of dental enamel (HP:0006297)2.46221520
35Abnormality of the distal phalanges of the toes (HP:0010182)2.46023154
36Bronchomalacia (HP:0002780)2.42673609
37Cerebral aneurysm (HP:0004944)2.41565804
38Oligodontia (HP:0000677)2.32511461
39Urethral obstruction (HP:0000796)2.30231632
40Shallow orbits (HP:0000586)2.29000256
41Ridged nail (HP:0001807)2.25155589
42Increased connective tissue (HP:0009025)2.22682393
43Sparse lateral eyebrow (HP:0005338)2.21756694
44Premature rupture of membranes (HP:0001788)2.21561585
45Malnutrition (HP:0004395)2.17955390
46Sparse scalp hair (HP:0002209)2.17851688
47Abnormality of the gastric mucosa (HP:0004295)2.13813365
48Hyperkalemia (HP:0002153)2.12727201
49Trismus (HP:0000211)2.10542667
50Osteolytic defects of the phalanges of the hand (HP:0009771)2.06915775
51Osteolytic defects of the hand bones (HP:0009699)2.06915775
52Upper limb amyotrophy (HP:0009129)2.05933885
53Distal upper limb amyotrophy (HP:0007149)2.05933885
54Mildly elevated creatine phosphokinase (HP:0008180)2.03898032
55Aplasia cutis congenita (HP:0001057)2.02359846
56Abnormality of chloride homeostasis (HP:0011422)2.02345093
57Ureteral duplication (HP:0000073)2.00907665
58Abnormality of the nasal septum (HP:0000419)2.00510641
59Abnormal blistering of the skin (HP:0008066)2.00021152
60Hemorrhage of the eye (HP:0011885)1.99858922
61Abnormality of oral frenula (HP:0000190)1.99406008
62Germ cell neoplasia (HP:0100728)1.98316899
63Focal segmental glomerulosclerosis (HP:0000097)1.98255154
64Abnormality of monocarboxylic acid metabolism (HP:0010996)1.96468811
65Sparse eyelashes (HP:0000653)1.94505285
66Cervical subluxation (HP:0003308)1.93333329
67Abnormality of permanent molar morphology (HP:0011071)1.90275546
68Abnormality of the dental root (HP:0006486)1.90275546
69Taurodontia (HP:0000679)1.90275546
70Abnormality of the dental pulp (HP:0006479)1.90230999
71Protrusio acetabuli (HP:0003179)1.88712459
72Long palpebral fissure (HP:0000637)1.88587861
73Laryngomalacia (HP:0001601)1.87372086
74Hypoplastic labia majora (HP:0000059)1.86509372
75Abnormality of molar morphology (HP:0011070)1.83485741
76Abnormality of molar (HP:0011077)1.83485741
77Ectropion (HP:0000656)1.80195111
78Tibial bowing (HP:0002982)1.79457765
79Woolly hair (HP:0002224)1.78993290
80Long eyelashes (HP:0000527)1.75971187
81Ulnar bowing (HP:0003031)1.74678402
82Neonatal death (HP:0003811)1.73691970
83Dehydration (HP:0001944)1.73398967
84Lower limb amyotrophy (HP:0007210)1.72509251
85Aneurysm (HP:0002617)1.72198022
86Deviation of the thumb (HP:0009603)1.71341416
87Depressed nasal tip (HP:0000437)1.70841127
88Congenital ichthyosiform erythroderma (HP:0007431)1.70736065
89Neonatal hypoglycemia (HP:0001998)1.70032031
90Distal lower limb muscle weakness (HP:0009053)1.69096339
91Neonatal short-limb short stature (HP:0008921)1.69083810
92Abnormality of the labia majora (HP:0012881)1.68935395
93Curly hair (HP:0002212)1.68862624
94Absent eyelashes (HP:0000561)1.68377706
95Dysmetric saccades (HP:0000641)1.68263387
96Septate vagina (HP:0001153)1.67409325
97Amelogenesis imperfecta (HP:0000705)1.66824545
98Popliteal pterygium (HP:0009756)1.66553843
99Corneal erosion (HP:0200020)1.64857602
100Glomerulosclerosis (HP:0000096)1.63243966

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.71223755
2EPHA25.68319913
3SIK13.62506294
4TRIB33.58509076
5MET3.51850321
6CDK123.46198754
7RIPK12.94662650
8SMG12.64194551
9LMTK22.57948625
10EEF2K2.40882377
11ICK2.05840538
12WNK41.73702521
13CAMK1D1.70311777
14LATS11.68648827
15FGFR41.61552860
16PDGFRA1.59918202
17PTK21.56113818
18ERN11.43276337
19MTOR1.39871194
20MAP3K91.37121834
21PAK41.36910351
22CAMK1G1.30468338
23NME11.30376825
24EPHB11.29918476
25LATS21.21017518
26PTK61.19810876
27IRAK31.17197769
28FER1.11816066
29PKN21.08556750
30STK391.07224150
31PRPF4B1.06109017
32AKT31.04845605
33WNK11.02819036
34CDC42BPA0.96967758
35BMX0.94911501
36BRD40.88846131
37MAP3K130.87136488
38MST40.85985286
39MAP3K60.85657972
40NTRK10.83739391
41RPS6KB20.83714637
42PRKD20.82696896
43PRKD30.81975944
44MAP3K30.80897200
45MAP3K100.79150262
46PDGFRB0.78118313
47TTN0.77004427
48MARK20.75282461
49RPS6KA20.75233246
50MAP3K20.66640509
51TRPM70.66598015
52STK240.65631665
53MELK0.64266551
54STK380.60515178
55MAP3K70.59763787
56EPHB20.58673853
57CDK70.57096085
58CHUK0.56978840
59ERBB20.56815294
60DMPK0.50959946
61ERBB40.50314673
62NEK60.49156881
63MAPKAPK30.48820461
64CDK90.47433835
65STK38L0.47110388
66FGFR10.46266590
67TESK10.44981898
68PRKAA20.42959169
69SIK30.42644939
70PAK20.41942106
71TAOK10.41507353
72SGK30.41173152
73MAP3K10.39685023
74MAPK150.39470788
75MAP2K20.38453880
76HIPK20.37800455
77PRKG20.37566771
78NEK20.35413442
79PBK0.34894890
80MAP3K80.33912639
81RPS6KC10.33685142
82RPS6KL10.33685142
83FGFR30.32524321
84PRKCI0.31309649
85CDK60.30788191
86MAP2K60.30463508
87RPS6KA10.29984701
88RET0.28841181
89PRKAA10.28655974
90STK30.27627234
91PDPK10.27615084
92MAPK110.27531251
93MAPKAPK20.27481604
94TTK0.26982246
95CHEK10.26445271
96MAPK10.23146539
97TGFBR10.21774455
98TSSK60.19408004
99MAPK80.19184901
100MYLK0.19138299

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.50409785
2Adherens junction_Homo sapiens_hsa045202.30421875
3Notch signaling pathway_Homo sapiens_hsa043302.20150748
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.16070586
5ECM-receptor interaction_Homo sapiens_hsa045122.11591346
6Thyroid cancer_Homo sapiens_hsa052161.99168829
7Lysine degradation_Homo sapiens_hsa003101.78349388
8Fructose and mannose metabolism_Homo sapiens_hsa000511.66844311
9Tight junction_Homo sapiens_hsa045301.58807178
10Focal adhesion_Homo sapiens_hsa045101.51569254
11Central carbon metabolism in cancer_Homo sapiens_hsa052301.50108671
12Arginine biosynthesis_Homo sapiens_hsa002201.46661340
13Bladder cancer_Homo sapiens_hsa052191.44568742
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.44518400
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.44221687
16Small cell lung cancer_Homo sapiens_hsa052221.39792972
17Chronic myeloid leukemia_Homo sapiens_hsa052201.37354759
18Endometrial cancer_Homo sapiens_hsa052131.36050062
19MicroRNAs in cancer_Homo sapiens_hsa052061.31457048
20Amoebiasis_Homo sapiens_hsa051461.29832875
21Thyroid hormone signaling pathway_Homo sapiens_hsa049191.29632822
22Phenylalanine metabolism_Homo sapiens_hsa003601.28595197
23Protein digestion and absorption_Homo sapiens_hsa049741.28241311
24Histidine metabolism_Homo sapiens_hsa003401.24770593
25Proteoglycans in cancer_Homo sapiens_hsa052051.22921522
26Galactose metabolism_Homo sapiens_hsa000521.20709076
27Prostate cancer_Homo sapiens_hsa052151.19872994
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15720560
29Insulin resistance_Homo sapiens_hsa049311.15566162
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13252322
31Acute myeloid leukemia_Homo sapiens_hsa052211.12820713
32Fatty acid biosynthesis_Homo sapiens_hsa000611.11782000
33Insulin signaling pathway_Homo sapiens_hsa049101.11223466
34ErbB signaling pathway_Homo sapiens_hsa040121.08537024
35Renal cell carcinoma_Homo sapiens_hsa052111.07647626
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04813957
37Starch and sucrose metabolism_Homo sapiens_hsa005001.00726318
38AMPK signaling pathway_Homo sapiens_hsa041520.99255076
39Inositol phosphate metabolism_Homo sapiens_hsa005620.99086452
40Leukocyte transendothelial migration_Homo sapiens_hsa046700.98790367
41Bile secretion_Homo sapiens_hsa049760.96376257
42Choline metabolism in cancer_Homo sapiens_hsa052310.96328168
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94135334
44Hippo signaling pathway_Homo sapiens_hsa043900.94053659
45Hepatitis C_Homo sapiens_hsa051600.93576661
46Pancreatic cancer_Homo sapiens_hsa052120.93430820
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92193464
48Other glycan degradation_Homo sapiens_hsa005110.91617642
49Pancreatic secretion_Homo sapiens_hsa049720.90505879
50Vitamin digestion and absorption_Homo sapiens_hsa049770.90386974
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89445091
52Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88296786
53Biosynthesis of amino acids_Homo sapiens_hsa012300.87856495
54VEGF signaling pathway_Homo sapiens_hsa043700.86207378
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85597348
56Glucagon signaling pathway_Homo sapiens_hsa049220.85190861
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82007961
58Sphingolipid metabolism_Homo sapiens_hsa006000.81731953
59mTOR signaling pathway_Homo sapiens_hsa041500.81156298
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77761896
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77620141
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77194915
63Basal cell carcinoma_Homo sapiens_hsa052170.76749911
64GnRH signaling pathway_Homo sapiens_hsa049120.76392378
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76047166
66Estrogen signaling pathway_Homo sapiens_hsa049150.74874856
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74319028
68Non-small cell lung cancer_Homo sapiens_hsa052230.74103675
69Pentose phosphate pathway_Homo sapiens_hsa000300.73573679
70Vitamin B6 metabolism_Homo sapiens_hsa007500.72068719
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.71432065
72Arginine and proline metabolism_Homo sapiens_hsa003300.71147086
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69328585
74Pathways in cancer_Homo sapiens_hsa052000.66672139
75Thyroid hormone synthesis_Homo sapiens_hsa049180.66061313
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66031453
77Vibrio cholerae infection_Homo sapiens_hsa051100.64770997
78Axon guidance_Homo sapiens_hsa043600.61883215
79ABC transporters_Homo sapiens_hsa020100.61111325
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.56514527
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54371103
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.53709891
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53395325
84Renin-angiotensin system_Homo sapiens_hsa046140.53194996
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53158607
86Endocytosis_Homo sapiens_hsa041440.52510099
87TNF signaling pathway_Homo sapiens_hsa046680.51946061
88Fat digestion and absorption_Homo sapiens_hsa049750.51463981
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51344551
90Glioma_Homo sapiens_hsa052140.51153507
91Mineral absorption_Homo sapiens_hsa049780.49890838
92Apoptosis_Homo sapiens_hsa042100.48126245
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48075944
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48019705
95Glycerolipid metabolism_Homo sapiens_hsa005610.47989004
96Colorectal cancer_Homo sapiens_hsa052100.47275488
97Retinol metabolism_Homo sapiens_hsa008300.47082165
98TGF-beta signaling pathway_Homo sapiens_hsa043500.46719096
99Prolactin signaling pathway_Homo sapiens_hsa049170.46284618
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.46064154

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