ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	desmosome organization (GO:0002934)	9.69259195
2	bundle of His cell to Purkinje myocyte communication (GO:0086069)	9.14764222
3	regulation of water loss via skin (GO:0033561)	6.91658666
4	establishment of skin barrier (GO:0061436)	6.76015822
5	intestinal epithelial cell development (GO:0060576)	5.99369474
6	hemidesmosome assembly (GO:0031581)	5.70035077
7	keratinocyte proliferation (GO:0043616)	5.34822264
8	multicellular organismal water homeostasis (GO:0050891)	5.22754097
9	gap junction assembly (GO:0016264)	5.16438730
10	keratinization (GO:0031424)	5.12179492
11	negative regulation of keratinocyte proliferation (GO:0010839)	4.61046429
12	O-glycan processing (GO:0016266)	4.50138799
13	water homeostasis (GO:0030104)	4.43335632
14	tight junction assembly (GO:0070830)	4.41203818
15	keratinocyte development (GO:0003334)	4.40726114
16	maintenance of gastrointestinal epithelium (GO:0030277)	4.33727388
17	regulation of transforming growth factor beta1 production (GO:0032908)	4.25953838
18	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	4.17641306
19	keratinocyte differentiation (GO:0030216)	4.13959445
20	cellular glucuronidation (GO:0052695)	3.81635596
21	polarized epithelial cell differentiation (GO:0030859)	3.73960835
22	chemical homeostasis within a tissue (GO:0048875)	3.73346556
23	glucuronate metabolic process (GO:0019585)	3.68709578
24	uronic acid metabolic process (GO:0006063)	3.68709578
25	surfactant homeostasis (GO:0043129)	3.61610276
26	epidermal cell differentiation (GO:0009913)	3.60048565
27	cell-cell junction assembly (GO:0007043)	3.50254317
28	regulation of keratinocyte proliferation (GO:0010837)	3.47781983
29	nucleotide-sugar biosynthetic process (GO:0009226)	3.35960056
30	regulation of keratinocyte differentiation (GO:0045616)	3.33489993
31	epithelial structure maintenance (GO:0010669)	3.32447050
32	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	3.26828195
33	positive regulation of epidermal cell differentiation (GO:0045606)	3.23432440
34	auditory receptor cell differentiation (GO:0042491)	3.18527047
35	skin morphogenesis (GO:0043589)	3.16438440
36	positive regulation of Cdc42 GTPase activity (GO:0043089)	3.10738220
37	epidermis development (GO:0008544)	3.03056647
38	regulation of cholesterol homeostasis (GO:2000188)	3.02775393
39	ventricular cardiac muscle cell action potential (GO:0086005)	3.00435805
40	positive regulation of keratinocyte differentiation (GO:0045618)	2.99240613
41	positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360	2.98321521
42	negative regulation of cell fate specification (GO:0009996)	2.92973329
43	ER overload response (GO:0006983)	2.90851831
44	protein O-linked glycosylation (GO:0006493)	2.89673151
45	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	2.84388861
46	regulation of bile acid biosynthetic process (GO:0070857)	2.83782152
47	nodal signaling pathway (GO:0038092)	2.83542440
48	protein targeting to Golgi (GO:0000042)	2.82963631
49	establishment of planar polarity (GO:0001736)	2.82447573
50	establishment of tissue polarity (GO:0007164)	2.82447573
51	positive regulation of p38MAPK cascade (GO:1900745)	2.78515577
52	epithelial cell-cell adhesion (GO:0090136)	2.78197940
53	branching involved in mammary gland duct morphogenesis (GO:0060444)	2.77533175
54	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.75221325
55	establishment of protein localization to Golgi (GO:0072600)	2.74652824
56	flavonoid metabolic process (GO:0009812)	2.73799291
57	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	2.71317291
58	regulation of heart rate by cardiac conduction (GO:0086091)	2.66539811
59	trophectodermal cell differentiation (GO:0001829)	2.65216152
60	cellular response to epidermal growth factor stimulus (GO:0071364)	2.64989914
61	intermediate filament organization (GO:0045109)	2.64203451
62	regulation of nephron tubule epithelial cell differentiation (GO:0072182)	2.61232759
63	intestinal absorption (GO:0050892)	2.60872690
64	regulation of transforming growth factor beta production (GO:0071634)	2.59953844
65	regulation of G0 to G1 transition (GO:0070316)	2.59257072
66	Sertoli cell development (GO:0060009)	2.58980329
67	RNA-dependent DNA replication (GO:0006278)	2.58832757
68	establishment of apical/basal cell polarity (GO:0035089)	2.58364385
69	regulation of podosome assembly (GO:0071801)	2.57500866
70	telomere maintenance via telomerase (GO:0007004)	2.56725289
71	negative regulation of cell fate commitment (GO:0010454)	2.55438416
72	phenylpropanoid metabolic process (GO:0009698)	2.55253245
73	primary alcohol catabolic process (GO:0034310)	2.52498408
74	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	2.51086609
75	mammary gland epithelial cell proliferation (GO:0033598)	2.51023883
76	regulation of apoptotic process involved in morphogenesis (GO:1902337)	2.50490479
77	Leydig cell differentiation (GO:0033327)	2.48899893
78	regulation of epidermal cell differentiation (GO:0045604)	2.45412635
79	lung lobe morphogenesis (GO:0060463)	2.45369645
80	mammary gland alveolus development (GO:0060749)	2.45220017
81	cardiac right ventricle morphogenesis (GO:0003215)	2.44892560
82	nephron tubule formation (GO:0072079)	2.43494592
83	hypotonic response (GO:0006971)	2.42507779
84	peptide cross-linking (GO:0018149)	2.42045528
85	protein autoprocessing (GO:0016540)	2.39295726
86	urea cycle (GO:0000050)	2.39143367
87	diterpenoid biosynthetic process (GO:0016102)	2.38333668
88	regulation of cell fate specification (GO:0042659)	2.38127737
89	mitotic sister chromatid cohesion (GO:0007064)	2.37172613
90	urea metabolic process (GO:0019627)	2.36448709
91	regulation of transforming growth factor beta2 production (GO:0032909)	2.36124048
92	ribosome assembly (GO:0042255)	2.35790924
93	protein complex localization (GO:0031503)	2.33838519
94	hair cell differentiation (GO:0035315)	2.33537340
95	sphingomyelin metabolic process (GO:0006684)	2.33111934
96	positive regulation of epidermis development (GO:0045684)	2.31777722
97	hair cycle (GO:0042633)	2.31594292
98	molting cycle (GO:0042303)	2.31594292
99	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	2.31531641
100	columnar/cuboidal epithelial cell development (GO:0002066)	2.30860346

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	8.06799131
2	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	5.33274996
3	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	4.84726959
4	ESR1_21235772_ChIP-Seq_MCF-7_Human	3.55052400
5	CDX2_20551321_ChIP-Seq_CACO-2_Human	3.05134103
6	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.00092381
7	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.84398394
8	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.82843916
9	AR_21909140_ChIP-Seq_LNCAP_Human	2.74368540
10	SOX2_27498859_Chip-Seq_STOMACH_Mouse	2.62859041
11	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	2.62207990
12	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	2.62207990
13	FOXO3_23340844_ChIP-Seq_DLD1_Human	2.60836369
14	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.57168031
15	GATA6_25053715_ChIP-Seq_YYC3_Human	2.49274685
16	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	2.41019207
17	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	2.31016437
18	SOX2_20726797_ChIP-Seq_SW620_Human	2.25429446
19	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.18483472
20	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.17172248
21	GATA3_24758297_ChIP-Seq_MCF-7_Human	2.10717868
22	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.09198767
23	GATA4_25053715_ChIP-Seq_YYC3_Human	2.07502208
24	PPAR_26484153_Chip-Seq_NCI-H1993_Human	2.01435468
25	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.95544679
26	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.94897864
27	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.88735113
28	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.86304352
29	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.79899558
30	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.79744991
31	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.74231101
32	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.72663881
33	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.68903222
34	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.68335751
35	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.66244028
36	ZNF263_19887448_ChIP-Seq_K562_Human	1.65588569
37	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.63486355
38	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.62295678
39	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.60746864
40	ATF3_27146783_Chip-Seq_COLON_Human	1.58173996
41	CHD1_26751641_Chip-Seq_LNCaP_Human	1.57625566
42	KLF5_25053715_ChIP-Seq_YYC3_Human	1.57170792
43	AHR_22903824_ChIP-Seq_MCF-7_Human	1.53084218
44	RACK7_27058665_Chip-Seq_MCF-7_Human	1.51722383
45	CLOCK_20551151_ChIP-Seq_293T_Human	1.50905043
46	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.47990536
47	ELF5_23300383_ChIP-Seq_T47D_Human	1.47976164
48	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.42990983
49	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	1.36513842
50	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.34631858
51	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.34201265
52	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.32477808
53	TP63_23658742_ChIP-Seq_EP156T_Human	1.30968246
54	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.30629307
55	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.28793699
56	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.28740174
57	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.24687765
58	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.23375089
59	CJUN_26792858_Chip-Seq_BT549_Human	1.17796322
60	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.17271393
61	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.16072957
62	* CDX2_22108803_ChIP-Seq_LS180_Human	1.13645995
63	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.13066502
64	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.12291497
65	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.10809617
66	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09548967
67	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.08573454
68	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.06792327
69	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.05375959
70	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.03985711
71	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.02163199
72	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.97892433
73	E2F7_22180533_ChIP-Seq_HELA_Human	0.95786303
74	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.95754737
75	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.95672891
76	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.95057774
77	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.94839065
78	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.93818054
79	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.90180959
80	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	0.88671178
81	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.85530063
82	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	0.84396381
83	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.84304220
84	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.81459549
85	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.81279777
86	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.81094093
87	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.80994912
88	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.78540893
89	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.78507027
90	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.76507890
91	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.76032262
92	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.75675773
93	TCF3_18692474_ChIP-Seq_MESCs_Mouse	0.75503825
94	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.75284725
95	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.74418433
96	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.71991414
97	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.70175950
98	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.69615962
99	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.69496250
100	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.68033060

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	5.92937849
2	MP0002796_impaired_skin_barrier	5.20943066
3	MP0000579_abnormal_nail_morphology	3.85329970
4	MP0003941_abnormal_skin_development	3.67241792
5	MP0004264_abnormal_extraembryonic_tissu	3.44447489
6	MP0005501_abnormal_skin_physiology	3.24328686
7	MP0010678_abnormal_skin_adnexa	3.05222939
8	MP0010352_gastrointestinal_tract_polyps	2.78800843
9	MP0005275_abnormal_skin_tensile	2.77857519
10	MP0002098_abnormal_vibrissa_morphology	2.40140727
11	MP0002060_abnormal_skin_morphology	2.34398799
12	MP0000383_abnormal_hair_follicle	2.30744545
13	MP0001666_abnormal_nutrient_absorption	2.28007899
14	MP0001216_abnormal_epidermal_layer	2.25074768
15	MP0003453_abnormal_keratinocyte_physiol	2.17173449
16	MP0004019_abnormal_vitamin_homeostasis	2.15723912
17	MP0000566_synostosis	2.13022626
18	MP0003693_abnormal_embryo_hatching	2.09088321
19	MP0003566_abnormal_cell_adhesion	2.04032937
20	MP0004043_abnormal_pH_regulation	1.88389191
21	MP0010771_integument_phenotype	1.87641305
22	MP0000762_abnormal_tongue_morphology	1.86850099
23	MP0004957_abnormal_blastocyst_morpholog	1.71358348
24	MP0000377_abnormal_hair_follicle	1.71131008
25	MP0002254_reproductive_system_inflammat	1.70345931
26	MP0000467_abnormal_esophagus_morphology	1.61543896
27	MP0004782_abnormal_surfactant_physiolog	1.60854176
28	MP0002139_abnormal_hepatobiliary_system	1.59630349
29	MP0009780_abnormal_chondrocyte_physiolo	1.57204856
30	MP0005365_abnormal_bile_salt	1.52907103
31	MP0003705_abnormal_hypodermis_morpholog	1.46986134
32	MP0005085_abnormal_gallbladder_physiolo	1.46098896
33	MP0000627_abnormal_mammary_gland	1.45035838
34	MP0000537_abnormal_urethra_morphology	1.39629295
35	MP0004272_abnormal_basement_membrane	1.38658612
36	MP0001881_abnormal_mammary_gland	1.29309086
37	MP0002877_abnormal_melanocyte_morpholog	1.27709512
38	MP0001188_hyperpigmentation	1.25856698
39	MP0005023_abnormal_wound_healing	1.23152807
40	MP0000462_abnormal_digestive_system	1.22864210
41	MP0000427_abnormal_hair_cycle	1.21306471
42	MP0009379_abnormal_foot_pigmentation	1.19603302
43	MP0000678_abnormal_parathyroid_gland	1.18754941
44	MP0005257_abnormal_intraocular_pressure	1.17443119
45	MP0005076_abnormal_cell_differentiation	1.13248805
46	MP0001765_abnormal_ion_homeostasis	1.12814958
47	MP0003890_abnormal_embryonic-extraembry	1.12322619
48	MP0003183_abnormal_peptide_metabolism	1.12099042
49	MP0008057_abnormal_DNA_replication	1.11872762
50	MP0000647_abnormal_sebaceous_gland	1.10505223
51	MP0005083_abnormal_biliary_tract	1.10356567
52	MP0005408_hypopigmentation	1.06806222
53	MP0003252_abnormal_bile_duct	1.05080798
54	MP0002138_abnormal_hepatobiliary_system	1.04027232
55	MP0000013_abnormal_adipose_tissue	1.01431576
56	MP0003718_maternal_effect	0.98476285
57	MP0004185_abnormal_adipocyte_glucose	0.95938183
58	MP0009931_abnormal_skin_appearance	0.95151160
59	MP0003868_abnormal_feces_composition	0.90967855
60	MP0001730_embryonic_growth_arrest	0.90449752
61	MP0000470_abnormal_stomach_morphology	0.89126210
62	MP0001191_abnormal_skin_condition	0.89028697
63	MP0003315_abnormal_perineum_morphology	0.85090463
64	MP0000477_abnormal_intestine_morphology	0.83051345
65	MP0000367_abnormal_coat/_hair	0.81383356
66	MP0005409_darkened_coat_color	0.81274578
67	MP0001664_abnormal_digestion	0.80715866
68	MP0009384_cardiac_valve_regurgitation	0.80221284
69	MP0003786_premature_aging	0.80121890
70	MP0008004_abnormal_stomach_pH	0.77173940
71	MP0003936_abnormal_reproductive_system	0.77066815
72	MP0003937_abnormal_limbs/digits/tail_de	0.76875068
73	MP0005636_abnormal_mineral_homeostasis	0.74806853
74	MP0009643_abnormal_urine_homeostasis	0.73202966
75	MP0000003_abnormal_adipose_tissue	0.70883173
76	MP0001849_ear_inflammation	0.70377833
77	MP0005332_abnormal_amino_acid	0.70274683
78	MP0010307_abnormal_tumor_latency	0.69594338
79	MP0005395_other_phenotype	0.69532625
80	MP0002111_abnormal_tail_morphology	0.69367015
81	MP0002697_abnormal_eye_size	0.68145262
82	MP0001873_stomach_inflammation	0.67832559
83	MP0000350_abnormal_cell_proliferation	0.67774015
84	MP0001756_abnormal_urination	0.65494712
85	MP0005375_adipose_tissue_phenotype	0.64507824
86	MP0004947_skin_inflammation	0.64400060
87	MP0003186_abnormal_redox_activity	0.63746161
88	MP0000432_abnormal_head_morphology	0.63735681
89	MP0003195_calcinosis	0.63609857
90	MP0002086_abnormal_extraembryonic_tissu	0.62880223
91	MP0002277_abnormal_respiratory_mucosa	0.62100305
92	MP0003111_abnormal_nucleus_morphology	0.62026044
93	MP0001485_abnormal_pinna_reflex	0.61989852
94	MP0003866_abnormal_defecation	0.61366279
95	MP0009672_abnormal_birth_weight	0.60852919
96	MP0002084_abnormal_developmental_patter	0.60737365
97	MP0002909_abnormal_adrenal_gland	0.60299495
98	MP0001851_eye_inflammation	0.60060752
99	MP0005666_abnormal_adipose_tissue	0.58459860
100	MP0003984_embryonic_growth_retardation	0.58200740

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Right ventricular cardiomyopathy (HP:0011663)	6.94830808
2	Pili torti (HP:0003777)	5.46343906
3	Plantar hyperkeratosis (HP:0007556)	4.54417617
4	Palmoplantar hyperkeratosis (HP:0000972)	4.32086160
5	Alopecia of scalp (HP:0002293)	4.25070932
6	Abnormality of nail color (HP:0100643)	4.23371195
7	Abnormal hair laboratory examination (HP:0003328)	4.14504738
8	Palmar hyperkeratosis (HP:0010765)	4.13402593
9	Sparse eyelashes (HP:0000653)	3.98918776
10	Hyperactive renin-angiotensin system (HP:0000841)	3.81729637
11	Onycholysis (HP:0001806)	3.81657850
12	Milia (HP:0001056)	3.72814654
13	Lip pit (HP:0100267)	3.70576066
14	Woolly hair (HP:0002224)	3.61832520
15	Fragile nails (HP:0001808)	3.56084761
16	Intrahepatic cholestasis (HP:0001406)	3.29516793
17	Hypoplasia of dental enamel (HP:0006297)	3.18136804
18	Hypotrichosis (HP:0001006)	3.17771811
19	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.17707571
20	Vascular calcification (HP:0004934)	3.10492215
21	Abnormality of the dental root (HP:0006486)	2.94853598
22	Taurodontia (HP:0000679)	2.94853598
23	Abnormality of permanent molar morphology (HP:0011071)	2.94853598
24	Selective tooth agenesis (HP:0001592)	2.94442427
25	Abnormality of the dental pulp (HP:0006479)	2.92423332
26	Atrophic scars (HP:0001075)	2.83869540
27	Tetraparesis (HP:0002273)	2.79076063
28	Sparse scalp hair (HP:0002209)	2.77953319
29	Abnormality of the nasal septum (HP:0000419)	2.77661341
30	Chronic bronchitis (HP:0004469)	2.74823460
31	Abnormality of molar morphology (HP:0011070)	2.74716244
32	Abnormality of molar (HP:0011077)	2.74716244
33	Oral leukoplakia (HP:0002745)	2.74678041
34	Congenital ichthyosiform erythroderma (HP:0007431)	2.72253210
35	Cardiovascular calcification (HP:0011915)	2.71895554
36	Hypoplastic labia majora (HP:0000059)	2.71287984
37	Natal tooth (HP:0000695)	2.62836956
38	Thick nail (HP:0001805)	2.59976363
39	Curly hair (HP:0002212)	2.58159698
40	Septate vagina (HP:0001153)	2.55857201
41	Abnormality of chloride homeostasis (HP:0011422)	2.54632264
42	Abnormality of the salivary glands (HP:0010286)	2.52952096
43	Malnutrition (HP:0004395)	2.51153078
44	Conjugated hyperbilirubinemia (HP:0002908)	2.50291055
45	Dry hair (HP:0011359)	2.49181324
46	Abnormality of the labia majora (HP:0012881)	2.43380031
47	Nail dystrophy (HP:0008404)	2.43107888
48	Hyperkalemia (HP:0002153)	2.41760672
49	Absent eyelashes (HP:0000561)	2.38819701
50	Hyperphosphatemia (HP:0002905)	2.36819935
51	Abnormality of the gastric mucosa (HP:0004295)	2.34898091
52	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.24210810
53	Oligodontia (HP:0000677)	2.21978025
54	Focal segmental glomerulosclerosis (HP:0000097)	2.20659861
55	Abnormality of small intestinal villus morphology (HP:0011472)	2.19904498
56	Villous atrophy (HP:0011473)	2.19904498
57	Corneal erosion (HP:0200020)	2.19394839
58	Advanced eruption of teeth (HP:0006288)	2.18847195
59	Abnormal biliary tract morphology (HP:0012440)	2.15146251
60	Abnormal blistering of the skin (HP:0008066)	2.12459485
61	Aplasia cutis congenita (HP:0001057)	2.12002814
62	Abnormality of the axillary hair (HP:0100134)	2.09657641
63	Abnormality of secondary sexual hair (HP:0009888)	2.09657641
64	Glomerulosclerosis (HP:0000096)	2.08920091
65	Flat acetabular roof (HP:0003180)	2.05921681
66	Dehydration (HP:0001944)	2.03549550
67	Abnormality of renin-angiotensin system (HP:0000847)	2.00621690
68	Decreased circulating renin level (HP:0003351)	1.97244580
69	Fragile skin (HP:0001030)	1.94910777
70	Pterygium (HP:0001059)	1.94789845
71	Depressed nasal tip (HP:0000437)	1.94411330
72	Popliteal pterygium (HP:0009756)	1.94274559
73	Trismus (HP:0000211)	1.93544175
74	Ridged nail (HP:0001807)	1.91524140
75	Palmoplantar keratoderma (HP:0000982)	1.90749213
76	Nasolacrimal duct obstruction (HP:0000579)	1.90398315
77	Amniotic constriction ring (HP:0009775)	1.89262821
78	Abnormality of placental membranes (HP:0011409)	1.89262821
79	Urethral obstruction (HP:0000796)	1.88072803
80	Biliary tract neoplasm (HP:0100574)	1.87814724
81	Ureteral duplication (HP:0000073)	1.87691674
82	Abnormality of the preputium (HP:0100587)	1.87051037
83	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.85306560
84	Abnormality of the distal phalanges of the toes (HP:0010182)	1.83855296
85	Abnormality of the lacrimal duct (HP:0011481)	1.83803792
86	Congenital, generalized hypertrichosis (HP:0004540)	1.82790186
87	Hydroxyprolinuria (HP:0003080)	1.81599607
88	Abnormality of proline metabolism (HP:0010907)	1.81599607
89	Amelogenesis imperfecta (HP:0000705)	1.80174928
90	Abnormality of vitamin metabolism (HP:0100508)	1.77049343
91	Short nail (HP:0001799)	1.76611977
92	Gout (HP:0001997)	1.72932052
93	Erythema (HP:0010783)	1.72267217
94	Abdominal distention (HP:0003270)	1.71261338
95	Blepharitis (HP:0000498)	1.70106313
96	Hoarse voice (HP:0001609)	1.69865193
97	Ankyloglossia (HP:0010296)	1.68340661
98	Labial hypoplasia (HP:0000066)	1.68076917
99	Erythroderma (HP:0001019)	1.68016165
100	Abnormalities of placenta or umbilical cord (HP:0001194)	1.62849068

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST1R	6.18153823
2	EPHA2	5.32803824
3	MST4	4.80634146
4	WNK4	3.84555502
5	STK39	3.49807906
6	STK24	3.21529204
7	MET	3.12689009
8	LMTK2	2.47824288
9	NME1	2.06941119
10	STK38L	1.73935753
11	LATS1	1.72723707
12	CDK12	1.72263315
13	PBK	1.64643751
14	WNK1	1.61608455
15	BRSK2	1.58162515
16	STK3	1.50051316
17	TAF1	1.48181198
18	MAP3K2	1.46371003
19	TTK	1.44058518
20	LATS2	1.40389768
21	ACVR1B	1.40080040
22	RIPK1	1.33313671
23	RPS6KB2	1.31010404
24	MAP3K9	1.30372281
25	BRSK1	1.25242905
26	MAP3K12	1.23014543
27	SIK1	1.16347673
28	MKNK2	1.15149601
29	PIK3CA	1.14556473
30	FER	1.12829397
31	PTK2	1.12102380
32	SMG1	1.08527483
33	TNIK	1.06452123
34	PAK4	1.04311523
35	MAPKAPK3	1.01659689
36	DMPK	0.96719954
37	OXSR1	0.88488767
38	PRKG2	0.86868529
39	PRKCI	0.83927863
40	MELK	0.83914688
41	MKNK1	0.74162199
42	TRPM7	0.69914701
43	TSSK6	0.68889192
44	MAP3K3	0.68526803
45	FGFR1	0.64954903
46	NLK	0.64319532
47	EIF2AK1	0.61842711
48	TGFBR1	0.61385225
49	BUB1	0.60497304
50	FGFR4	0.59938925
51	CSNK1E	0.59288552
52	AURKB	0.58902878
53	MTOR	0.57320945
54	NEK6	0.55760675
55	TRIM28	0.53612141
56	MYLK	0.52594795
57	CDK7	0.52556484
58	FRK	0.52412045
59	NME2	0.51530494
60	CHUK	0.51225951
61	ERBB4	0.50711328
62	TESK1	0.49761719
63	GRK1	0.48534535
64	EIF2AK3	0.47651370
65	PTK6	0.47363003
66	ERBB2	0.46020365
67	PLK1	0.42915220
68	MAP2K6	0.42429794
69	CAMK1D	0.42365995
70	STK10	0.42275623
71	CHEK1	0.41859998
72	VRK2	0.40672066
73	CAMK1G	0.40084884
74	EPHB2	0.39985583
75	NEK2	0.37834853
76	BRD4	0.37376472
77	BCR	0.37340019
78	TRIB3	0.37285647
79	PRKCE	0.36055630
80	STK38	0.35889041
81	BMPR1B	0.33784531
82	MAP3K8	0.32025649
83	AKT2	0.30919251
84	PRKAA2	0.29166927
85	CDC7	0.29014204
86	ALK	0.28498385
87	TAOK1	0.28025592
88	WEE1	0.27394800
89	MAPKAPK2	0.26581272
90	LRRK2	0.26197531
91	MAP3K10	0.25476313
92	PDGFRB	0.24697891
93	IRAK3	0.23877714
94	IRAK1	0.23002763
95	ATM	0.22645617
96	BMX	0.21583532
97	SIK3	0.20928514
98	EEF2K	0.20617872
99	CDC42BPA	0.20460350
100	IGF1R	0.20348453

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	3.27530713
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.08489561
3	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.42915684
4	Retinol metabolism_Homo sapiens_hsa00830	2.37402004
5	Caffeine metabolism_Homo sapiens_hsa00232	2.30360392
6	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.30335231
7	Sulfur metabolism_Homo sapiens_hsa00920	2.21497394
8	Thyroid cancer_Homo sapiens_hsa05216	2.18061035
9	Histidine metabolism_Homo sapiens_hsa00340	2.10551419
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.07907285
11	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.05925022
12	Tight junction_Homo sapiens_hsa04530	2.05447411
13	Starch and sucrose metabolism_Homo sapiens_hsa00500	2.04965331
14	Chemical carcinogenesis_Homo sapiens_hsa05204	2.03685700
15	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.00116470
16	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.98323512
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.94344502
18	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.90233116
19	Adherens junction_Homo sapiens_hsa04520	1.82478579
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.80976969
21	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.78875022
22	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.75304215
23	Arginine biosynthesis_Homo sapiens_hsa00220	1.71044746
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.60142685
25	Mineral absorption_Homo sapiens_hsa04978	1.57830176
26	Glutathione metabolism_Homo sapiens_hsa00480	1.54276243
27	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.45261527
28	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.43242900
29	Arginine and proline metabolism_Homo sapiens_hsa00330	1.38789056
30	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.38185236
31	Phenylalanine metabolism_Homo sapiens_hsa00360	1.30779587
32	Sphingolipid metabolism_Homo sapiens_hsa00600	1.27700523
33	Galactose metabolism_Homo sapiens_hsa00052	1.18955814
34	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.18454867
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.16173649
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.11881877
37	Protein digestion and absorption_Homo sapiens_hsa04974	1.09092602
38	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.07353212
39	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.06643978
40	Fat digestion and absorption_Homo sapiens_hsa04975	1.06083910
41	Tyrosine metabolism_Homo sapiens_hsa00350	1.04407016
42	ECM-receptor interaction_Homo sapiens_hsa04512	1.00381317
43	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.98693961
44	Pancreatic secretion_Homo sapiens_hsa04972	0.94905026
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.92604169
46	beta-Alanine metabolism_Homo sapiens_hsa00410	0.90578728
47	RNA transport_Homo sapiens_hsa03013	0.90386639
48	Fatty acid degradation_Homo sapiens_hsa00071	0.90285652
49	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.89451056
50	Bile secretion_Homo sapiens_hsa04976	0.89433449
51	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.87566557
52	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.85827440
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.85052175
54	Circadian rhythm_Homo sapiens_hsa04710	0.83701536
55	Tryptophan metabolism_Homo sapiens_hsa00380	0.77812732
56	Lysine degradation_Homo sapiens_hsa00310	0.76051403
57	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.75716363
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.74808849
59	Vibrio cholerae infection_Homo sapiens_hsa05110	0.72015318
60	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.67587192
61	Pyruvate metabolism_Homo sapiens_hsa00620	0.64274526
62	Hepatitis C_Homo sapiens_hsa05160	0.63967810
63	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.63847157
64	Basal transcription factors_Homo sapiens_hsa03022	0.63298068
65	Renin-angiotensin system_Homo sapiens_hsa04614	0.63193997
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62984087
67	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.61606885
68	Hippo signaling pathway_Homo sapiens_hsa04390	0.59725731
69	ABC transporters_Homo sapiens_hsa02010	0.58327582
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.57617526
71	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.56083797
72	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.55908334
73	Non-homologous end-joining_Homo sapiens_hsa03450	0.54740013
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.54409729
75	p53 signaling pathway_Homo sapiens_hsa04115	0.53811735
76	Oocyte meiosis_Homo sapiens_hsa04114	0.52870511
77	Folate biosynthesis_Homo sapiens_hsa00790	0.51448009
78	Protein export_Homo sapiens_hsa03060	0.49479761
79	PPAR signaling pathway_Homo sapiens_hsa03320	0.49208000
80	Amoebiasis_Homo sapiens_hsa05146	0.47048160
81	Metabolic pathways_Homo sapiens_hsa01100	0.46892997
82	Nitrogen metabolism_Homo sapiens_hsa00910	0.46028682
83	Prostate cancer_Homo sapiens_hsa05215	0.44855526
84	Propanoate metabolism_Homo sapiens_hsa00640	0.44821123
85	Proteoglycans in cancer_Homo sapiens_hsa05205	0.44756629
86	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.44733029
87	One carbon pool by folate_Homo sapiens_hsa00670	0.43699484
88	Glucagon signaling pathway_Homo sapiens_hsa04922	0.41545308
89	Small cell lung cancer_Homo sapiens_hsa05222	0.40177113
90	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39341326
91	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.38132058
92	Proteasome_Homo sapiens_hsa03050	0.37062782
93	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.36183630
94	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.36129530
95	Base excision repair_Homo sapiens_hsa03410	0.34855756
96	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.34738278
97	MicroRNAs in cancer_Homo sapiens_hsa05206	0.34724276
98	RNA polymerase_Homo sapiens_hsa03020	0.33980770
99	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.33688659
100	Insulin resistance_Homo sapiens_hsa04931	0.32776235

ARHGEF35

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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