ARHGEF37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.36872306
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.36872306
3L-phenylalanine metabolic process (GO:0006558)6.11159296
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.11159296
5desmosome organization (GO:0002934)5.83753253
6aromatic amino acid family catabolic process (GO:0009074)5.60304494
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.50526988
8sulfur amino acid catabolic process (GO:0000098)5.42543888
9alpha-linolenic acid metabolic process (GO:0036109)5.13513311
10kynurenine metabolic process (GO:0070189)5.05553292
11tryptophan catabolic process (GO:0006569)4.98941627
12indole-containing compound catabolic process (GO:0042436)4.98941627
13indolalkylamine catabolic process (GO:0046218)4.98941627
14bile acid biosynthetic process (GO:0006699)4.98490216
15complement activation, alternative pathway (GO:0006957)4.89594474
16establishment of skin barrier (GO:0061436)4.87584388
17urea cycle (GO:0000050)4.86943418
18urea metabolic process (GO:0019627)4.86943418
19tryptophan metabolic process (GO:0006568)4.80853050
20coenzyme catabolic process (GO:0009109)4.78249893
21glyoxylate metabolic process (GO:0046487)4.72731802
22protein carboxylation (GO:0018214)4.66825501
23peptidyl-glutamic acid carboxylation (GO:0017187)4.66825501
24nitrogen cycle metabolic process (GO:0071941)4.60115006
25regulation of water loss via skin (GO:0033561)4.59226833
26regulation of triglyceride catabolic process (GO:0010896)4.55578289
27cellular modified amino acid catabolic process (GO:0042219)4.54283934
28high-density lipoprotein particle remodeling (GO:0034375)4.52617906
29regulation of protein activation cascade (GO:2000257)4.52121195
30cysteine metabolic process (GO:0006534)4.51657972
31homocysteine metabolic process (GO:0050667)4.51213308
32negative regulation of fibrinolysis (GO:0051918)4.45493238
33tyrosine metabolic process (GO:0006570)4.43318142
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.36542504
35hemidesmosome assembly (GO:0031581)4.35861980
36bile acid metabolic process (GO:0008206)4.29963976
37regulation of complement activation (GO:0030449)4.28048457
38plasma lipoprotein particle clearance (GO:0034381)4.27493740
39regulation of fibrinolysis (GO:0051917)4.26109077
40keratinization (GO:0031424)4.21694964
41serine family amino acid catabolic process (GO:0009071)4.19564514
42amino-acid betaine metabolic process (GO:0006577)4.17182990
43aromatic amino acid family metabolic process (GO:0009072)4.15107234
44triglyceride homeostasis (GO:0070328)4.14063814
45acylglycerol homeostasis (GO:0055090)4.14063814
46phospholipid efflux (GO:0033700)4.11246996
47multicellular organismal water homeostasis (GO:0050891)4.09035990
48bundle of His cell to Purkinje myocyte communication (GO:0086069)4.06197714
49reverse cholesterol transport (GO:0043691)4.02677044
50lysine metabolic process (GO:0006553)4.02204151
51lysine catabolic process (GO:0006554)4.02204151
52epoxygenase P450 pathway (GO:0019373)4.01652020
53regulation of cholesterol homeostasis (GO:2000188)3.99889134
54alpha-amino acid catabolic process (GO:1901606)3.94730252
55plasma lipoprotein particle remodeling (GO:0034369)3.94533732
56protein-lipid complex remodeling (GO:0034368)3.94533732
57macromolecular complex remodeling (GO:0034367)3.94533732
58cytoskeletal anchoring at plasma membrane (GO:0007016)3.85953877
59cellular amino acid catabolic process (GO:0009063)3.81992833
60regulation of cholesterol esterification (GO:0010872)3.81811621
61positive regulation of lipid catabolic process (GO:0050996)3.81183433
62sodium ion export (GO:0071436)3.80233048
63negative regulation of cholesterol transport (GO:0032375)3.80137275
64negative regulation of sterol transport (GO:0032372)3.80137275
65cofactor catabolic process (GO:0051187)3.71345241
66drug catabolic process (GO:0042737)3.64323357
67cellular ketone body metabolic process (GO:0046950)3.64116778
68bile acid and bile salt transport (GO:0015721)3.61211613
69positive regulation of fatty acid beta-oxidation (GO:0032000)3.60788854
70cellular potassium ion homeostasis (GO:0030007)3.57564043
71glutamate metabolic process (GO:0006536)3.55104104
72intestinal cholesterol absorption (GO:0030299)3.53879152
73indolalkylamine metabolic process (GO:0006586)3.53553815
74ethanol oxidation (GO:0006069)3.53476951
75short-chain fatty acid metabolic process (GO:0046459)3.53413928
76cholesterol efflux (GO:0033344)3.53393532
77water homeostasis (GO:0030104)3.52149836
78dicarboxylic acid biosynthetic process (GO:0043650)3.50277174
79positive regulation of lipoprotein lipase activity (GO:0051006)3.46367780
80positive regulation of triglyceride lipase activity (GO:0061365)3.46367780
81phospholipid homeostasis (GO:0055091)3.44502923
82keratinocyte proliferation (GO:0043616)3.44306094
83acetyl-CoA metabolic process (GO:0006084)3.42902198
84cellular glucuronidation (GO:0052695)3.41851622
85negative regulation of lipase activity (GO:0060192)3.41623540
86fibrinolysis (GO:0042730)3.40776272
87imidazole-containing compound metabolic process (GO:0052803)3.38464191
88carboxylic acid catabolic process (GO:0046395)3.38122393
89organic acid catabolic process (GO:0016054)3.38122393
90drug metabolic process (GO:0017144)3.37067464
91flavonoid metabolic process (GO:0009812)3.36718950
92cholesterol homeostasis (GO:0042632)3.36526490
93fatty acid beta-oxidation (GO:0006635)3.34179459
94ketone body metabolic process (GO:1902224)3.33815132
95biotin metabolic process (GO:0006768)3.33785329
96linoleic acid metabolic process (GO:0043651)3.32841494
97valine metabolic process (GO:0006573)3.32777423
98hormone catabolic process (GO:0042447)3.32342111
99arginine metabolic process (GO:0006525)3.31643952
100primary alcohol catabolic process (GO:0034310)3.31520405
101sterol homeostasis (GO:0055092)3.31117505
102glycine metabolic process (GO:0006544)3.30854952
103cell communication involved in cardiac conduction (GO:0086065)3.30513039
104fatty acid oxidation (GO:0019395)3.28718587
105amine catabolic process (GO:0009310)3.27629574
106cellular biogenic amine catabolic process (GO:0042402)3.27629574
107exogenous drug catabolic process (GO:0042738)3.27133654
108regulation of bile acid biosynthetic process (GO:0070857)3.26616139
109benzene-containing compound metabolic process (GO:0042537)3.26211702
110plasma lipoprotein particle assembly (GO:0034377)3.25369891
111lipid oxidation (GO:0034440)3.23316456
112low-density lipoprotein particle clearance (GO:0034383)3.23227366
113complement activation (GO:0006956)3.22326934
114cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.20847068
115positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.03790635
116ventricular cardiac muscle cell action potential (GO:0086005)2.96278319
117skeletal muscle adaptation (GO:0043501)2.95384893
118myelin maintenance (GO:0043217)2.93986330
119macroautophagy (GO:0016236)2.89362076
120long-chain fatty acid biosynthetic process (GO:0042759)2.85263783
121peptide cross-linking (GO:0018149)2.83317430
122one-carbon compound transport (GO:0019755)2.79556705
123regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.74747048
124intermediate filament organization (GO:0045109)2.72514819
125synaptic vesicle docking involved in exocytosis (GO:0016081)2.71378966
126cell communication by electrical coupling (GO:0010644)2.71276534
127cell-substrate junction assembly (GO:0007044)2.68886644
128molting cycle (GO:0042303)2.68343530
129hair cycle (GO:0042633)2.68343530
130potassium ion homeostasis (GO:0055075)2.68324995
131sexual reproduction (GO:0019953)2.67032766
132creatine metabolic process (GO:0006600)2.60061914
133neuronal ion channel clustering (GO:0045161)2.58336582
134central nervous system myelination (GO:0022010)2.54824839
135axon ensheathment in central nervous system (GO:0032291)2.54824839
136epidermis development (GO:0008544)2.52951102
137glomerular basement membrane development (GO:0032836)2.51175105
138keratinocyte differentiation (GO:0030216)2.51084025
139regulation of p38MAPK cascade (GO:1900744)2.50534165
140cellular sodium ion homeostasis (GO:0006883)2.48653450
141cardiac muscle contraction (GO:0060048)2.48033555
142plasma membrane repair (GO:0001778)2.47753191
143cell volume homeostasis (GO:0006884)2.44942174
144cardiac conduction (GO:0061337)2.43223540
145muscle filament sliding (GO:0030049)2.41015690
146actin-myosin filament sliding (GO:0033275)2.41015690
147negative regulation of protein localization to cell surface (GO:2000009)2.39888571
148apical protein localization (GO:0045176)2.37910862
149regulation of cell communication by electrical coupling (GO:0010649)2.37483501
150regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.33969283
151peptidyl-tyrosine autophosphorylation (GO:0038083)2.33796003
152regulation of actin filament-based movement (GO:1903115)2.32693750
153negative regulation of inclusion body assembly (GO:0090084)2.32065765
154regulation of protein localization to cell surface (GO:2000008)2.31843203
155potassium ion import (GO:0010107)2.31746894
156sodium ion homeostasis (GO:0055078)2.31600964
157chemical homeostasis within a tissue (GO:0048875)2.29999760
158NADH metabolic process (GO:0006734)2.29932354
159response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.29165713
160endothelial cell chemotaxis (GO:0035767)2.28559813
161peripheral nervous system axon ensheathment (GO:0032292)2.27494700
162myelination in peripheral nervous system (GO:0022011)2.27494700
163sarcoplasmic reticulum calcium ion transport (GO:0070296)2.25363595
164striated muscle contraction (GO:0006941)2.25320940
165positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.24916526
166regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.24880739
167cardiac muscle cell action potential (GO:0086001)2.23722381
168epithelial cell differentiation involved in prostate gland development (GO:0060742)2.23421362
169carnitine transmembrane transport (GO:1902603)2.23149849
170insulin-like growth factor receptor signaling pathway (GO:0048009)2.23020019
171relaxation of cardiac muscle (GO:0055119)2.22887614
172ethanol metabolic process (GO:0006067)2.22708513
173glutamate secretion (GO:0014047)2.22194024
174import into cell (GO:0098657)2.21717839
175regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.19967465
176iron ion import (GO:0097286)2.19321569
177peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.18793339
178regulation of heart rate by cardiac conduction (GO:0086091)2.18559835
179cardiac muscle cell action potential involved in contraction (GO:0086002)2.17685509
180gap junction assembly (GO:0016264)2.16009380
181carnitine transport (GO:0015879)2.15804802
182amino-acid betaine transport (GO:0015838)2.15804802
183membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.15126304
184metanephric nephron epithelium development (GO:0072243)2.14485481
185regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.14403434
186myofibril assembly (GO:0030239)2.14262891
187diterpenoid biosynthetic process (GO:0016102)2.14179963
188carnitine metabolic process (GO:0009437)2.13141051
189regulation of sodium ion transmembrane transport (GO:1902305)2.12006036
190surfactant homeostasis (GO:0043129)2.11865962
191carnitine shuttle (GO:0006853)2.11852017
192cerebellar granule cell differentiation (GO:0021707)2.11725778
193striated muscle hypertrophy (GO:0014897)2.11262773
194sarcomere organization (GO:0045214)2.09061254
195regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.08297788
196epidermal cell differentiation (GO:0009913)2.07204963
197metanephric nephron tubule development (GO:0072234)2.07166090

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.78306236
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.48734183
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.68878577
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.29911935
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.87935954
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.82192945
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.48156676
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.66321020
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.21303364
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.67237149
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.49681506
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.39626815
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80702816
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71331926
15ESR2_21235772_ChIP-Seq_MCF-7_Human1.64875044
16DROSHA_22980978_ChIP-Seq_HELA_Human1.63691276
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58832545
18AHR_22903824_ChIP-Seq_MCF-7_Human1.56764259
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53856117
20FOXA2_19822575_ChIP-Seq_HepG2_Human1.53099731
21GATA1_22025678_ChIP-Seq_K562_Human1.50805811
22ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45605782
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45451429
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44321017
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44148295
26CLOCK_20551151_ChIP-Seq_293T_Human1.41323267
27TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.40490440
28EP300_21415370_ChIP-Seq_HL-1_Mouse1.39691786
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38099293
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.36800723
31CTNNB1_20460455_ChIP-Seq_HCT116_Human1.32282246
32CDX2_20551321_ChIP-Seq_CACO-2_Human1.32161659
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29325210
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.29192748
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28360435
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.25518611
37ARNT_22903824_ChIP-Seq_MCF-7_Human1.25383434
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24609188
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24609188
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24609188
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.24306816
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.22639867
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21071041
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.21028932
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20877008
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18586480
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17757552
48* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16848719
49HNF4A_19822575_ChIP-Seq_HepG2_Human1.16307512
50* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14783081
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14679021
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.14170835
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.14170835
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12840676
55SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12840676
56* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11264257
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.11196998
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10697953
59CTCF_27219007_Chip-Seq_Bcells_Human1.09988327
60RARB_27405468_Chip-Seq_BRAIN_Mouse1.09900264
61GATA4_25053715_ChIP-Seq_YYC3_Human1.07813315
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07348119
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07122277
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06624288
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05648333
66LXR_22292898_ChIP-Seq_THP-1_Human1.05281023
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04863443
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.04432464
69AR_21572438_ChIP-Seq_LNCaP_Human1.03334550
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02907144
71KLF5_25053715_ChIP-Seq_YYC3_Human1.02647619
72EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02575379
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02175219
74RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01274013
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01138973
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00765032
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98551766
78TET1_21490601_ChIP-Seq_MESCs_Mouse0.98416472
79RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98135222
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97724921
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96173492
82CREB1_26743006_Chip-Seq_LNCaP_Human0.96067392
83SMAD3_21741376_ChIP-Seq_HESCs_Human0.94904801
84P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93775988
85HTT_18923047_ChIP-ChIP_STHdh_Human0.92469228
86STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91911114
87ESR1_20079471_ChIP-ChIP_T-47D_Human0.90739162
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89836546
89FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89730202
90KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89009745
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88975635
92BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88727487
93HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88658604
94EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88494037
95P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88273096
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87634404
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87431602
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86192201
99FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85861044
100SOX9_24532713_ChIP-Seq_HFSC_Mouse0.83913860
101ERG_21242973_ChIP-ChIP_JURKAT_Human0.81846523
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81589650
103* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81462974
104* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80573413
105RACK7_27058665_Chip-Seq_MCF-7_Human0.80175680
106TRIM28_21343339_ChIP-Seq_HEK293_Human0.79563683
107PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79374181
108GATA2_21666600_ChIP-Seq_HMVEC_Human0.79201901
109ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79045347
110GATA6_25053715_ChIP-Seq_YYC3_Human0.78044791
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.73660146
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73591425
113* GATA3_24758297_ChIP-Seq_MCF-7_Human0.72259104
114SOX2_20726797_ChIP-Seq_SW620_Human0.71428573
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.71228920
116EGR1_19032775_ChIP-ChIP_M12_Human0.71010559
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.70269012
118ZNF217_24962896_ChIP-Seq_MCF-7_Human0.69137261
119* TP63_22573176_ChIP-Seq_HFKS_Human0.68400096
120TBX20_22328084_ChIP-Seq_HEART_Mouse0.68025464
121TBX20_22080862_ChIP-Seq_HEART_Mouse0.68025464
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.66648369
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66140294
124NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66140294
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.65922845
126ESET_19884257_ChIP-Seq_ESCs_Mouse0.65877800
127BCOR_27268052_Chip-Seq_Bcells_Human0.65074422
128PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.63134297
129NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.62911437
130* TP63_23658742_ChIP-Seq_EP156T_Human0.61429009
131PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.61208235
132KDM2B_26808549_Chip-Seq_K562_Human0.61061006
133GATA2_19941826_ChIP-Seq_K562_Human0.60630898
134SALL4_18804426_ChIP-ChIP_XEN_Mouse0.60472499
135AUTS2_25519132_ChIP-Seq_293T-REX_Human0.60415925
136CSB_26484114_Chip-Seq_FIBROBLAST_Human0.60396927
137GATA1_19941826_ChIP-Seq_K562_Human0.59459362
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.58633495
139PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.57885284
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.57479417
141* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.57250891
142TCF3_18692474_ChIP-Seq_MESCs_Mouse0.56741262
143* CEBPB_22108803_ChIP-Seq_LS180_Human0.56535950
144* FOXA1_25552417_ChIP-Seq_VCAP_Human0.55807095
145TCF3_18692474_ChIP-Seq_MEFs_Mouse0.55000203
146SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.54870139
147* SMC4_20622854_ChIP-Seq_HELA_Human0.54762957
148RUNX1_27514584_Chip-Seq_MCF-7_Human0.54743624
149ZNF263_19887448_ChIP-Seq_K562_Human0.54514111

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.06953647
2MP0005360_urolithiasis6.55413280
3MP0005365_abnormal_bile_salt5.53695954
4MP0005085_abnormal_gallbladder_physiolo5.36738438
5MP0008875_abnormal_xenobiotic_pharmacok4.38494417
6MP0009780_abnormal_chondrocyte_physiolo3.39854830
7MP0005083_abnormal_biliary_tract3.36127026
8MP0010329_abnormal_lipoprotein_level3.32005466
9MP0003252_abnormal_bile_duct3.29161358
10MP0003806_abnormal_nucleotide_metabolis3.14311703
11MP0009840_abnormal_foam_cell2.89233132
12MP0001666_abnormal_nutrient_absorption2.59561094
13MP0003195_calcinosis2.54636048
14MP0003705_abnormal_hypodermis_morpholog2.54533167
15MP0003191_abnormal_cellular_cholesterol2.52484979
16MP0003011_delayed_dark_adaptation2.50279747
17MP0002254_reproductive_system_inflammat2.45500776
18MP0000566_synostosis2.39753471
19MP0005332_abnormal_amino_acid2.35371580
20MP0005377_hearing/vestibular/ear_phenot2.26712195
21MP0003878_abnormal_ear_physiology2.26712195
22MP0000751_myopathy2.25418405
23MP0005409_darkened_coat_color2.19690757
24MP0000609_abnormal_liver_physiology2.08468657
25MP0002118_abnormal_lipid_homeostasis2.07582473
26MP0004019_abnormal_vitamin_homeostasis1.93095621
27MP0003879_abnormal_hair_cell1.91537886
28MP0004885_abnormal_endolymph1.86140860
29MP0004270_analgesia1.84769040
30MP0004036_abnormal_muscle_relaxation1.84325698
31MP0005319_abnormal_enzyme/_coenzyme1.79365875
32MP0005670_abnormal_white_adipose1.76187959
33MP0002796_impaired_skin_barrier1.69628816
34MP0000467_abnormal_esophagus_morphology1.61206700
35MP0000749_muscle_degeneration1.59424007
36MP0005451_abnormal_body_composition1.57432202
37MP0004145_abnormal_muscle_electrophysio1.56607336
38MP0003868_abnormal_feces_composition1.55262643
39MP0000762_abnormal_tongue_morphology1.48708657
40MP0004084_abnormal_cardiac_muscle1.43733722
41MP0005584_abnormal_enzyme/coenzyme_acti1.42743934
42MP0003566_abnormal_cell_adhesion1.42446135
43MP0004264_abnormal_extraembryonic_tissu1.40378658
44MP0000013_abnormal_adipose_tissue1.40135847
45MP0003941_abnormal_skin_development1.36801009
46MP0010386_abnormal_urinary_bladder1.32727010
47MP0000747_muscle_weakness1.30682767
48MP0010771_integument_phenotype1.30423711
49MP0004381_abnormal_hair_follicle1.29132512
50MP0005330_cardiomyopathy1.27390904
51MP0004087_abnormal_muscle_fiber1.25435257
52MP0009379_abnormal_foot_pigmentation1.21364812
53MP0004215_abnormal_myocardial_fiber1.20891495
54MP0000003_abnormal_adipose_tissue1.20724405
55MP0004859_abnormal_synaptic_plasticity1.20015947
56MP0005620_abnormal_muscle_contractility1.18859102
57MP0009643_abnormal_urine_homeostasis1.16495771
58MP0002138_abnormal_hepatobiliary_system1.16244403
59MP0009764_decreased_sensitivity_to1.15569249
60MP0004272_abnormal_basement_membrane1.14050848
61MP0004130_abnormal_muscle_cell1.13796847
62MP0002971_abnormal_brown_adipose1.12576016
63MP0003045_fibrosis1.11705148
64MP0000604_amyloidosis1.11439375
65MP0008569_lethality_at_weaning1.10362267
66MP0002972_abnormal_cardiac_muscle1.09121225
67MP0003186_abnormal_redox_activity1.08495856
68MP0001502_abnormal_circadian_rhythm1.08157689
69MP0006138_congestive_heart_failure1.07010271
70MP0005248_abnormal_Harderian_gland1.06935232
71MP0008961_abnormal_basal_metabolism1.05592090
72MP0009697_abnormal_copulation1.05383140
73MP0010234_abnormal_vibrissa_follicle1.04803494
74MP0002909_abnormal_adrenal_gland1.04607229
75MP0002332_abnormal_exercise_endurance1.00067634
76MP0005666_abnormal_adipose_tissue0.99507722
77MP0003690_abnormal_glial_cell0.97302784
78MP0001984_abnormal_olfaction0.96851053
79MP0002108_abnormal_muscle_morphology0.95951645
80MP0003656_abnormal_erythrocyte_physiolo0.95595700
81MP0000678_abnormal_parathyroid_gland0.95515444
82MP0000598_abnormal_liver_morphology0.95179254
83MP0004484_altered_response_of0.93872735
84MP0001764_abnormal_homeostasis0.93481836
85MP0000579_abnormal_nail_morphology0.92800775
86MP0004858_abnormal_nervous_system0.91447100
87MP0009763_increased_sensitivity_to0.90045543
88MP0003453_abnormal_keratinocyte_physiol0.89249885
89MP0005423_abnormal_somatic_nervous0.88349741
90MP0005535_abnormal_body_temperature0.87664195
91MP0001765_abnormal_ion_homeostasis0.86717257
92MP0004043_abnormal_pH_regulation0.86670444
93MP0000462_abnormal_digestive_system0.86645530
94MP0002896_abnormal_bone_mineralization0.86073905
95MP0000920_abnormal_myelination0.85644973
96MP0003329_amyloid_beta_deposits0.84722462
97MP0002078_abnormal_glucose_homeostasis0.83387588
98MP0005408_hypopigmentation0.83369545
99MP0000759_abnormal_skeletal_muscle0.83115911
100MP0006035_abnormal_mitochondrial_morpho0.82688864
101MP0003950_abnormal_plasma_membrane0.82562410
102MP0005334_abnormal_fat_pad0.80405562
103MP0005275_abnormal_skin_tensile0.79415649
104MP0002060_abnormal_skin_morphology0.78755723
105MP0005647_abnormal_sex_gland0.78387774
106MP0006082_CNS_inflammation0.77913720
107MP0008469_abnormal_protein_level0.77691279
108MP0010630_abnormal_cardiac_muscle0.77414374
109MP0005266_abnormal_metabolism0.77325884
110MP0002837_dystrophic_cardiac_calcinosis0.76605635
111MP0004782_abnormal_surfactant_physiolog0.76321211
112MP0004233_abnormal_muscle_weight0.75077807
113MP0001501_abnormal_sleep_pattern0.74833089
114MP0005448_abnormal_energy_balance0.74404819
115MP0004185_abnormal_adipocyte_glucose0.73034825
116MP0004947_skin_inflammation0.72553951
117MP0006036_abnormal_mitochondrial_physio0.72491548
118MP0002876_abnormal_thyroid_physiology0.71398089
119MP0009642_abnormal_blood_homeostasis0.70610736
120MP0010368_abnormal_lymphatic_system0.70529978
121MP0004085_abnormal_heartbeat0.69010948
122MP0003075_altered_response_to0.68133218
123MP0001664_abnormal_digestion0.68016353
124MP0003634_abnormal_glial_cell0.67389219
125MP0005376_homeostasis/metabolism_phenot0.66878794
126MP0002734_abnormal_mechanical_nocicepti0.66117244
127MP0009115_abnormal_fat_cell0.65632056
128MP0005257_abnormal_intraocular_pressure0.65423780
129MP0000427_abnormal_hair_cycle0.65060245
130MP0002970_abnormal_white_adipose0.64898327
131MP0005369_muscle_phenotype0.64376528
132MP0001849_ear_inflammation0.64339064
133MP0009765_abnormal_xenobiotic_induced0.64220954
134MP0009931_abnormal_skin_appearance0.64097640
135MP0005501_abnormal_skin_physiology0.64052940
136MP0005636_abnormal_mineral_homeostasis0.63361362
137MP0000627_abnormal_mammary_gland0.62990259
138MP0002822_catalepsy0.62672591
139MP0000537_abnormal_urethra_morphology0.62566146
140MP0000647_abnormal_sebaceous_gland0.61780338
141MP0003183_abnormal_peptide_metabolism0.61708372
142MP0005075_abnormal_melanosome_morpholog0.61078191
143MP0001756_abnormal_urination0.60342775
144MP0003436_decreased_susceptibility_to0.57405241
145MP0001216_abnormal_epidermal_layer0.57235152
146MP0005375_adipose_tissue_phenotype0.56206180
147MP0002098_abnormal_vibrissa_morphology0.52798069
148MP0000383_abnormal_hair_follicle0.51434347
149MP0000377_abnormal_hair_follicle0.51123671
150MP0002269_muscular_atrophy0.50845516
151MP0010678_abnormal_skin_adnexa0.49683076
152MP0001324_abnormal_eye_pigmentation0.44536854
153MP0008874_decreased_physiological_sensi0.43691838
154MP0001243_abnormal_dermal_layer0.43536423
155MP0002136_abnormal_kidney_physiology0.43498923
156MP0000639_abnormal_adrenal_gland0.42801786
157MP0003890_abnormal_embryonic-extraembry0.42405515
158MP0001661_extended_life_span0.42172949
159MP0002090_abnormal_vision0.40695116
160MP0005023_abnormal_wound_healing0.39768317
161MP0005220_abnormal_exocrine_pancreas0.39758547

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.40648422
2Intrahepatic cholestasis (HP:0001406)6.36343261
3Xanthomatosis (HP:0000991)6.19948958
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.94739382
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.49731024
6Prolonged partial thromboplastin time (HP:0003645)5.28009894
7Hypobetalipoproteinemia (HP:0003563)4.86253094
8Hyperlipoproteinemia (HP:0010980)4.84299896
9Complement deficiency (HP:0004431)4.81349168
10Epidermoid cyst (HP:0200040)4.71051092
11Abnormality of nail color (HP:0100643)4.52829542
12Hyperammonemia (HP:0001987)4.26995387
13Ketosis (HP:0001946)4.14579853
14Hyporeflexia of lower limbs (HP:0002600)4.07862426
15Hypolipoproteinemia (HP:0010981)4.07393092
16Joint hemorrhage (HP:0005261)4.05791575
17Hyperglycinuria (HP:0003108)4.00866969
18Hypoalphalipoproteinemia (HP:0003233)3.99144505
19Abnormality of the intrinsic pathway (HP:0010989)3.87166174
20Abnormality of serine family amino acid metabolism (HP:0010894)3.84491796
21Abnormality of glycine metabolism (HP:0010895)3.84491796
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.81132992
23Hypochromic microcytic anemia (HP:0004840)3.80866765
24Exercise-induced myalgia (HP:0003738)3.79441363
25Hypoglycemic coma (HP:0001325)3.79431697
26Hyperglycinemia (HP:0002154)3.79322098
27Abnormality of the common coagulation pathway (HP:0010990)3.79068353
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.72108450
29Onycholysis (HP:0001806)3.68665567
30Abnormality of complement system (HP:0005339)3.67435202
31Skin nodule (HP:0200036)3.65025972
32Abnormality of glutamine family amino acid metabolism (HP:0010902)3.61977176
33Fat malabsorption (HP:0002630)3.60639596
34Plantar hyperkeratosis (HP:0007556)3.52689179
35Palmoplantar hyperkeratosis (HP:0000972)3.49418087
36Ketoacidosis (HP:0001993)3.41264664
37Hyperkalemia (HP:0002153)3.39267953
38Hypercholesterolemia (HP:0003124)3.37086324
39Abnormality of aspartate family amino acid metabolism (HP:0010899)3.35425309
40Abnormality of methionine metabolism (HP:0010901)3.33099712
41Muscle fiber splitting (HP:0003555)3.28176175
42Palmar hyperkeratosis (HP:0010765)3.21118191
43Hyperinsulinemic hypoglycemia (HP:0000825)3.15149109
44Bundle branch block (HP:0011710)3.09845846
45Conjugated hyperbilirubinemia (HP:0002908)3.09681155
46Myocardial infarction (HP:0001658)3.09274251
47Ventricular tachycardia (HP:0004756)3.05201168
48Sudden death (HP:0001699)3.04936987
49Hypotrichosis (HP:0001006)3.03502825
50Distal lower limb muscle weakness (HP:0009053)3.02591687
51Pili torti (HP:0003777)2.95348446
52Abnormality of secondary sexual hair (HP:0009888)2.92536777
53Abnormality of the axillary hair (HP:0100134)2.92536777
54Abnormality of the salivary glands (HP:0010286)2.89657458
55Alopecia of scalp (HP:0002293)2.88374007
56Systemic lupus erythematosus (HP:0002725)2.87121277
57Abnormality of fatty-acid metabolism (HP:0004359)2.86983418
58Milia (HP:0001056)2.82629973
59Muscle fiber inclusion bodies (HP:0100299)2.82498438
60Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.78983856
61Amyloidosis (HP:0011034)2.78253349
62Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.72130053
63Nemaline bodies (HP:0003798)2.71527569
64Steatorrhea (HP:0002570)2.71034114
65Hyperbilirubinemia (HP:0002904)2.69812186
66Abnormality of purine metabolism (HP:0004352)2.68483436
67Corneal erosion (HP:0200020)2.68089121
68Type 1 muscle fiber predominance (HP:0003803)2.63563175
69Abnormality of nucleobase metabolism (HP:0010932)2.63467838
70Malnutrition (HP:0004395)2.62541108
71Obstructive sleep apnea (HP:0002870)2.62018985
72Exercise-induced muscle cramps (HP:0003710)2.58924904
73Woolly hair (HP:0002224)2.55396260
74Abnormal gallbladder morphology (HP:0012437)2.54618946
75Increased IgE level (HP:0003212)2.53915464
76Lip pit (HP:0100267)2.53854381
77Abnormality of pyrimidine metabolism (HP:0004353)2.53436642
78Gout (HP:0001997)2.52903630
79Abnormal cartilage morphology (HP:0002763)2.51622308
80Metabolic acidosis (HP:0001942)2.51480076
81Syncope (HP:0001279)2.51002395
82Cholelithiasis (HP:0001081)2.49997035
83Aplasia involving bones of the upper limbs (HP:0009823)2.49996186
84Aplasia of the phalanges of the hand (HP:0009802)2.49996186
85Aplasia involving bones of the extremities (HP:0009825)2.49996186
86Abnormality of the lower motor neuron (HP:0002366)2.49459509
87Dicarboxylic aciduria (HP:0003215)2.49199286
88Abnormality of dicarboxylic acid metabolism (HP:0010995)2.49199286
89Hyperactive renin-angiotensin system (HP:0000841)2.48299372
90Abnormality of the Achilles tendon (HP:0005109)2.47052644
91Hepatocellular carcinoma (HP:0001402)2.45729549
92Fragile nails (HP:0001808)2.41552482
93Delayed CNS myelination (HP:0002188)2.40642335
94Thick nail (HP:0001805)2.40584952
95EMG: myopathic abnormalities (HP:0003458)2.38212632
96Hypoglycemic seizures (HP:0002173)2.38133910
97Erythema (HP:0010783)2.37986382
98Abnormal hair laboratory examination (HP:0003328)2.31027975
99Abnormality of the calf musculature (HP:0001430)2.30957658
100Right ventricular cardiomyopathy (HP:0011663)2.30025831
101Spastic diplegia (HP:0001264)2.29343936
102Recurrent gram-negative bacterial infections (HP:0005420)2.29271149
103Neurofibrillary tangles (HP:0002185)2.29127635
104Increased connective tissue (HP:0009025)2.28113578
105Abnormality of serum amino acid levels (HP:0003112)2.28105998
106Asymmetric septal hypertrophy (HP:0001670)2.27265540
107Cholecystitis (HP:0001082)2.26661430
108Abnormal gallbladder physiology (HP:0012438)2.26661430
109Palmoplantar keratoderma (HP:0000982)2.26511429
110Abnormality of permanent molar morphology (HP:0011071)2.25975127
111Abnormality of the dental root (HP:0006486)2.25975127
112Taurodontia (HP:0000679)2.25975127
113Glomerulonephritis (HP:0000099)2.25589489
114Alacrima (HP:0000522)2.24583161
115Hemorrhage of the eye (HP:0011885)2.24056050
116Ventricular fibrillation (HP:0001663)2.22483677
117Difficulty running (HP:0009046)2.20944568
118Muscle hypertrophy of the lower extremities (HP:0008968)2.19915685
119Advanced eruption of teeth (HP:0006288)2.19631371
120Irritability (HP:0000737)2.19202755
121Esophageal varix (HP:0002040)2.18220132
122Ankle clonus (HP:0011448)2.17708726
123Vascular calcification (HP:0004934)2.17179682
124Cerebral inclusion bodies (HP:0100314)2.16051297
125Myopathic facies (HP:0002058)2.14340695
126Congenital ichthyosiform erythroderma (HP:0007431)2.13529552
127Abnormal atrioventricular conduction (HP:0005150)2.13468831
128Calf muscle hypertrophy (HP:0008981)2.11963780
129Heart block (HP:0012722)2.11618432
130Mitral stenosis (HP:0001718)2.09990850
131Abnormality of molar morphology (HP:0011070)2.09422331
132Abnormality of molar (HP:0011077)2.09422331
133Tetraplegia (HP:0002445)2.05094038
134Neonatal onset (HP:0003623)2.04274837
135Hepatoblastoma (HP:0002884)2.04223517
136Conjunctival hamartoma (HP:0100780)2.03559688
137Ventricular arrhythmia (HP:0004308)2.03516271
138Pancreatitis (HP:0001733)2.03469731
139EMG: neuropathic changes (HP:0003445)2.02123869
140Myoglobinuria (HP:0002913)2.01721523
141Lethargy (HP:0001254)2.01018286
142Multiple enchondromatosis (HP:0005701)1.97497513
143Centrally nucleated skeletal muscle fibers (HP:0003687)1.96979289
144Neoplasm of the heart (HP:0100544)1.96963298
145Abnormality of the dental pulp (HP:0006479)1.96919370
146Bronchomalacia (HP:0002780)1.96836648
147Status epilepticus (HP:0002133)1.96558646
148Laryngomalacia (HP:0001601)1.95835505
149Hypoplasia of dental enamel (HP:0006297)1.95110733
150Foot dorsiflexor weakness (HP:0009027)1.94556181
151Popliteal pterygium (HP:0009756)1.92950536
152Abnormality of the gallbladder (HP:0005264)1.92512552
153Cardiovascular calcification (HP:0011915)1.92260063
154Upper motor neuron abnormality (HP:0002127)1.91918976
155Neck muscle weakness (HP:0000467)1.91333899
156Atrophic scars (HP:0001075)1.91321221
157Gingival bleeding (HP:0000225)1.90724100
158Hyperglycemia (HP:0003074)1.90516753
159Dysmetric saccades (HP:0000641)1.89811548
160Abnormal blistering of the skin (HP:0008066)1.87821428
161Polar cataract (HP:0010696)1.87808792
162Mildly elevated creatine phosphokinase (HP:0008180)1.87749795
163Nail dystrophy (HP:0008404)1.87686800
164Achilles tendon contracture (HP:0001771)1.87149803
165Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87074580
166Pseudobulbar signs (HP:0002200)1.86766247
167Vomiting (HP:0002013)1.86383656
168Late onset (HP:0003584)1.85887993
169Decreased lacrimation (HP:0000633)1.84931272
170Peritonitis (HP:0002586)1.84344446
171Menorrhagia (HP:0000132)1.83740880
172Atrioventricular block (HP:0001678)1.83367021
173Abnormality of proline metabolism (HP:0010907)1.82911679
174Hydroxyprolinuria (HP:0003080)1.82911679
175Spontaneous abortion (HP:0005268)1.81701461
176Abnormality of the foot musculature (HP:0001436)1.80433106
177Acanthocytosis (HP:0001927)1.79417731
178Abnormal enzyme/coenzyme activity (HP:0012379)1.79397869
179Abnormality of transition element cation homeostasis (HP:0011030)1.78001550
180Nephritis (HP:0000123)1.77202075
181Rickets (HP:0002748)1.76725732
182Sensorimotor neuropathy (HP:0007141)1.76638304
183Abnormality of iron homeostasis (HP:0011031)1.76442627
184Hamartoma of the eye (HP:0010568)1.75738831
185Ragged-red muscle fibers (HP:0003200)1.75690534
186Ridged nail (HP:0001807)1.75249727
187Abnormality of sodium homeostasis (HP:0010931)1.74793411
188Rhabdomyolysis (HP:0003201)1.71528499
189Increased variability in muscle fiber diameter (HP:0003557)1.70244960
190Acanthosis nigricans (HP:0000956)1.69377470
191Erythroderma (HP:0001019)1.69043374
192Scapular winging (HP:0003691)1.66131025
193Stridor (HP:0010307)1.65770408
194Myokymia (HP:0002411)1.64713599
195Aortic aneurysm (HP:0004942)1.64418012
196Hyperparathyroidism (HP:0000843)1.63495689
197Subaortic stenosis (HP:0001682)1.62950770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.55500095
2BCKDK3.85217484
3MST1R3.33059588
4SIK13.25934511
5CDK122.99391330
6FGFR42.72463885
7GRK52.63189387
8PRKD32.39353095
9GRK62.34367655
10INSRR2.34206405
11TRIB32.31887146
12PHKG12.29908566
13PHKG22.29908566
14LMTK22.25487897
15EEF2K2.25448113
16RIPK12.19048112
17MYLK2.15122292
18MAP2K41.98906507
19TGFBR21.77530117
20GRK11.75606002
21DMPK1.66726494
22LATS11.63559668
23TAOK31.58271248
24TRPM71.50736081
25PIK3CG1.47958306
26PTK61.45398741
27PKN21.39969707
28MET1.38291249
29FGFR31.37231192
30TYK21.30025113
31CSF1R1.28587402
32MATK1.27481693
33TESK11.26679507
34CAMK1D1.25868563
35CSK1.18525807
36SGK2231.15675226
37SGK4941.15675226
38MAP3K71.12201700
39ERBB41.11858354
40FGFR21.11667466
41TYRO31.11328360
42ADRBK21.10176798
43JAK11.08547853
44NEK61.08457861
45EPHA41.06651988
46MAPK71.06506763
47DAPK21.05928388
48NTRK11.04930195
49GRK71.04923548
50BMX1.03584218
51MAPK111.02497253
52JAK21.02406842
53EPHB11.02396652
54NTRK30.98789550
55SGK20.97273133
56FRK0.96684887
57WNK10.96640060
58MARK10.95912319
59UHMK10.95714818
60PRKAA20.94649734
61CAMK2G0.92737208
62MAPK120.91980770
63ARAF0.91901250
64CAMK40.89798145
65MOS0.88656616
66MAPKAPK30.88003734
67PDK20.85966847
68MAP3K100.85652500
69ERBB20.85551923
70STK100.85466336
71STK390.84676150
72CAMK2B0.82948864
73ROCK10.81652665
74PTK20.80901513
75PRKD20.80752091
76PRPF4B0.78625219
77KSR20.78493689
78MAP2K60.78261346
79PIK3CA0.77744101
80RPS6KA20.76882226
81FLT30.74527080
82STK240.73511553
83TAOK10.72645520
84FER0.70438669
85TIE10.70094922
86MAP3K30.69824310
87PRKG20.68473542
88PRKAA10.68402795
89ROCK20.67118216
90MAPKAPK50.66866591
91CDC42BPA0.66808976
92CAMK1G0.66268328
93PDGFRA0.65458564
94TNK20.64866859
95DDR20.64113589
96CAMK10.63936229
97MAP3K10.62428201
98GSK3A0.62187839
99EPHA20.62132746
100TBK10.61847385
101MAP2K10.61744874
102PINK10.61054628
103TTN0.60930508
104MAP3K120.60882967
105PRKACG0.60097574
106MAP3K20.57748069
107EPHA30.56872945
108MTOR0.56378813
109ABL20.54743362
110PAK60.54044039
111ADRBK10.53461073
112NEK90.53346782
113IGF1R0.52356792
114CAMK2D0.52350137
115SGK10.50976321
116ILK0.50273135
117AKT20.49396938
118MAP3K130.49216778
119PRKCH0.48984370
120CDK50.48560375
121ITK0.48066642
122MARK20.47820296
123PRKCZ0.47742918
124MAPK40.47645609
125RET0.46848434
126MAP3K90.46740997
127MAPK150.46387402
128MAPK100.46280397
129STK380.44779818
130STK38L0.43420017
131AKT30.43022327
132MAP2K30.42630390
133IRAK30.41896890
134DYRK1B0.39706730
135PDPK10.39401621
136HIPK20.39118217
137MAP3K140.38617342
138PRKD10.38521660
139PAK30.36957547
140LATS20.36697556
141SGK30.34748909
142PDK10.34520643
143CAMKK10.33791355
144FGFR10.30739271
145EPHB20.29500757
146MAP3K60.29017597
147ICK0.28643714
148OBSCN0.28112484

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.08154339
2Nitrogen metabolism_Homo sapiens_hsa009103.66656095
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.05088282
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.91181270
5Arginine biosynthesis_Homo sapiens_hsa002202.90635941
6Complement and coagulation cascades_Homo sapiens_hsa046102.60245714
7Tryptophan metabolism_Homo sapiens_hsa003802.58421478
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.52685632
9Fatty acid degradation_Homo sapiens_hsa000712.51603158
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.32772587
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.27717148
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.20125992
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.17542530
14PPAR signaling pathway_Homo sapiens_hsa033202.12676080
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.00029669
16Propanoate metabolism_Homo sapiens_hsa006401.99512844
17Staphylococcus aureus infection_Homo sapiens_hsa051501.92779623
18Butanoate metabolism_Homo sapiens_hsa006501.92477120
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.90705852
20Peroxisome_Homo sapiens_hsa041461.89957626
21Fatty acid metabolism_Homo sapiens_hsa012121.87152461
22Caffeine metabolism_Homo sapiens_hsa002321.86809422
23Chemical carcinogenesis_Homo sapiens_hsa052041.84659878
24Histidine metabolism_Homo sapiens_hsa003401.76832498
25Circadian rhythm_Homo sapiens_hsa047101.66967126
26beta-Alanine metabolism_Homo sapiens_hsa004101.63949470
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.63607265
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63568440
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.62972993
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61074153
31Bile secretion_Homo sapiens_hsa049761.57432697
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.56769845
33Retinol metabolism_Homo sapiens_hsa008301.55856981
34Vitamin B6 metabolism_Homo sapiens_hsa007501.51451463
35Phenylalanine metabolism_Homo sapiens_hsa003601.45034057
36Dilated cardiomyopathy_Homo sapiens_hsa054141.44758065
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43186148
38Tyrosine metabolism_Homo sapiens_hsa003501.41733916
39Sulfur metabolism_Homo sapiens_hsa009201.39312148
40Fat digestion and absorption_Homo sapiens_hsa049751.36969408
41ABC transporters_Homo sapiens_hsa020101.36238745
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.33441190
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33071597
44Starch and sucrose metabolism_Homo sapiens_hsa005001.32103804
45Gastric acid secretion_Homo sapiens_hsa049711.28325203
46Renin secretion_Homo sapiens_hsa049241.27895272
47Fatty acid elongation_Homo sapiens_hsa000621.27533312
48ECM-receptor interaction_Homo sapiens_hsa045121.24127773
49Selenocompound metabolism_Homo sapiens_hsa004501.23009671
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20851517
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20738990
52Pyruvate metabolism_Homo sapiens_hsa006201.18990979
53Insulin secretion_Homo sapiens_hsa049111.17720827
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15163146
55Vascular smooth muscle contraction_Homo sapiens_hsa042701.14766138
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14764361
57Carbon metabolism_Homo sapiens_hsa012001.11702670
58Salivary secretion_Homo sapiens_hsa049701.07872151
59Long-term potentiation_Homo sapiens_hsa047201.06686601
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04504250
61Tight junction_Homo sapiens_hsa045301.03949195
62GnRH signaling pathway_Homo sapiens_hsa049121.02498238
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00255821
64Biosynthesis of amino acids_Homo sapiens_hsa012301.00192395
65Pancreatic secretion_Homo sapiens_hsa049720.99722008
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.98756748
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.98399189
68Synaptic vesicle cycle_Homo sapiens_hsa047210.98100264
69Steroid biosynthesis_Homo sapiens_hsa001000.96803349
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96402860
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93857088
72Circadian entrainment_Homo sapiens_hsa047130.92505211
73Glycerolipid metabolism_Homo sapiens_hsa005610.92070299
74Folate biosynthesis_Homo sapiens_hsa007900.91557310
75Focal adhesion_Homo sapiens_hsa045100.91279837
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90822514
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90519270
78Fatty acid biosynthesis_Homo sapiens_hsa000610.88668908
79Amphetamine addiction_Homo sapiens_hsa050310.88066765
80Sphingolipid metabolism_Homo sapiens_hsa006000.86692774
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.85181839
82Oxytocin signaling pathway_Homo sapiens_hsa049210.85158139
83Lysine degradation_Homo sapiens_hsa003100.83976628
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83941981
85Estrogen signaling pathway_Homo sapiens_hsa049150.83503761
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82522369
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82480232
88Fructose and mannose metabolism_Homo sapiens_hsa000510.81313599
89Linoleic acid metabolism_Homo sapiens_hsa005910.78661736
90Vitamin digestion and absorption_Homo sapiens_hsa049770.78563067
91Glutamatergic synapse_Homo sapiens_hsa047240.77709824
92Inositol phosphate metabolism_Homo sapiens_hsa005620.77189020
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75986213
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73979750
95Arginine and proline metabolism_Homo sapiens_hsa003300.73687940
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73245583
97Choline metabolism in cancer_Homo sapiens_hsa052310.69319202
98Adherens junction_Homo sapiens_hsa045200.69110149
99VEGF signaling pathway_Homo sapiens_hsa043700.68802104
100Calcium signaling pathway_Homo sapiens_hsa040200.68498850
101cAMP signaling pathway_Homo sapiens_hsa040240.67226025
102Glioma_Homo sapiens_hsa052140.61387915
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.59385555
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58825376
105Dopaminergic synapse_Homo sapiens_hsa047280.58524241
106Sulfur relay system_Homo sapiens_hsa041220.58217841
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.58041785
108Melanogenesis_Homo sapiens_hsa049160.57834701
109Serotonergic synapse_Homo sapiens_hsa047260.57262242
110Cardiac muscle contraction_Homo sapiens_hsa042600.56974841
111Pentose phosphate pathway_Homo sapiens_hsa000300.56346353
112Galactose metabolism_Homo sapiens_hsa000520.55949081
113GABAergic synapse_Homo sapiens_hsa047270.55519150
114Long-term depression_Homo sapiens_hsa047300.54863106
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54327128
116Renal cell carcinoma_Homo sapiens_hsa052110.54149822
117Cocaine addiction_Homo sapiens_hsa050300.54039259
118ErbB signaling pathway_Homo sapiens_hsa040120.53764992
119Insulin resistance_Homo sapiens_hsa049310.51616194
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47576318
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45527151
122Glutathione metabolism_Homo sapiens_hsa004800.38134280
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.37851165
124Metabolic pathways_Homo sapiens_hsa011000.34338421
125Prion diseases_Homo sapiens_hsa050200.34036842
126Arachidonic acid metabolism_Homo sapiens_hsa005900.33247452
127AMPK signaling pathway_Homo sapiens_hsa041520.25450974
128Ovarian steroidogenesis_Homo sapiens_hsa049130.22897352
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21878423
130Glucagon signaling pathway_Homo sapiens_hsa049220.17878420
131One carbon pool by folate_Homo sapiens_hsa006700.15652637
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.12905142
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12499789
134Ether lipid metabolism_Homo sapiens_hsa005650.08858648
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.04762111
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.04627697
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.03249975
138Mineral absorption_Homo sapiens_hsa049780.02819536
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.02255110
140Insulin signaling pathway_Homo sapiens_hsa049100.01602638
141Hepatitis C_Homo sapiens_hsa051600.01327002
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00681658
143Renin-angiotensin system_Homo sapiens_hsa04614-0.0731617
144Lysosome_Homo sapiens_hsa04142-0.0590588
145Pertussis_Homo sapiens_hsa05133-0.0553672
146Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0294246
147Type II diabetes mellitus_Homo sapiens_hsa04930-0.0169689
148African trypanosomiasis_Homo sapiens_hsa05143-0.0157385
149Protein digestion and absorption_Homo sapiens_hsa04974-0.0131577
150Amoebiasis_Homo sapiens_hsa05146-0.0013892

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