ARHGEF38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chemical homeostasis within a tissue (GO:0048875)8.94703986
2negative regulation of transcription by competitive promoter binding (GO:0010944)5.12906798
3lung secretory cell differentiation (GO:0061140)5.11544436
4cilium or flagellum-dependent cell motility (GO:0001539)5.11202449
5UDP-N-acetylglucosamine metabolic process (GO:0006047)5.09252862
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.94837499
7bundle of His cell to Purkinje myocyte communication (GO:0086069)4.92386456
8pattern specification involved in kidney development (GO:0061004)4.85823653
9intestinal epithelial cell development (GO:0060576)4.63573241
10antibacterial humoral response (GO:0019731)4.59749409
11regulation of respiratory burst (GO:0060263)4.55264745
12calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.50818208
13negative regulation of epidermal cell differentiation (GO:0045605)4.40631932
14antimicrobial humoral response (GO:0019730)4.34068600
15axoneme assembly (GO:0035082)4.33361304
16hemidesmosome assembly (GO:0031581)4.25760846
17cilium movement (GO:0003341)4.21826690
18epithelial cilium movement (GO:0003351)4.15557231
19transepithelial transport (GO:0070633)4.13889050
20lung lobe morphogenesis (GO:0060463)4.09983758
21axonemal dynein complex assembly (GO:0070286)4.09608816
22intestinal absorption (GO:0050892)3.94084915
23indole-containing compound catabolic process (GO:0042436)3.92338015
24indolalkylamine catabolic process (GO:0046218)3.92338015
25tryptophan catabolic process (GO:0006569)3.92338015
26O-glycan processing (GO:0016266)3.82945050
27tight junction assembly (GO:0070830)3.80742268
28angiotensin maturation (GO:0002003)3.73439343
29response to lipoprotein particle (GO:0055094)3.72416784
30trivalent inorganic anion homeostasis (GO:0072506)3.70991710
31phosphate ion homeostasis (GO:0055062)3.70991710
32regulation of keratinocyte proliferation (GO:0010837)3.69352572
33epithelial cell differentiation involved in prostate gland development (GO:0060742)3.67446015
34regulation of hydrogen peroxide metabolic process (GO:0010310)3.59477619
35proline biosynthetic process (GO:0006561)3.56578135
36regulation of cilium movement (GO:0003352)3.53449161
37regulation of viral release from host cell (GO:1902186)3.47883581
38indolalkylamine metabolic process (GO:0006586)3.47577132
39peptide catabolic process (GO:0043171)3.45264226
40sulfate transmembrane transport (GO:1902358)3.38263065
41behavioral response to nicotine (GO:0035095)3.35375234
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.35017343
43bicarbonate transport (GO:0015701)3.33846301
44hypotonic response (GO:0006971)3.29484286
45kynurenine metabolic process (GO:0070189)3.29037670
46tryptophan metabolic process (GO:0006568)3.28285984
47benzene-containing compound metabolic process (GO:0042537)3.27257532
48regulation of viral entry into host cell (GO:0046596)3.27194855
49negative regulation of epidermis development (GO:0045683)3.26582515
50dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.19776420
51citrulline biosynthetic process (GO:0019240)3.19529419
52regulation of bile acid biosynthetic process (GO:0070857)3.17188692
53phosphate ion transmembrane transport (GO:0035435)3.13402106
54cellular response to nitric oxide (GO:0071732)3.12832307
55lung cell differentiation (GO:0060479)3.12335967
56diol metabolic process (GO:0034311)3.12070525
57positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.11951841
58multicellular organismal water homeostasis (GO:0050891)3.10375126
59photoreceptor cell maintenance (GO:0045494)3.08874072
60desmosome organization (GO:0002934)3.07094744
61sphingosine metabolic process (GO:0006670)3.06950713
62ethanol metabolic process (GO:0006067)3.03264202
63regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.01199819
64opsonization (GO:0008228)3.00634147
65sodium-independent organic anion transport (GO:0043252)3.00344210
66negative regulation of epithelial to mesenchymal transition (GO:0010719)2.99314038
67negative regulation of viral entry into host cell (GO:0046597)2.98902678
68detection of light stimulus involved in visual perception (GO:0050908)2.96314250
69detection of light stimulus involved in sensory perception (GO:0050962)2.96314250
70hormone catabolic process (GO:0042447)2.93701857
71adhesion of symbiont to host cell (GO:0044650)2.92951351
72virion attachment to host cell (GO:0019062)2.92951351
73defense response to fungus (GO:0050832)2.92024558
74establishment of apical/basal cell polarity (GO:0035089)2.90757090
75lung epithelial cell differentiation (GO:0060487)2.90499948
76embryonic foregut morphogenesis (GO:0048617)2.90427898
77sulfation (GO:0051923)2.90179162
78phosphate ion transport (GO:0006817)2.90073555
79cilium organization (GO:0044782)2.89828851
80response to pheromone (GO:0019236)2.89732052
81water-soluble vitamin biosynthetic process (GO:0042364)2.89485906
82transcytosis (GO:0045056)2.89332831
83thyroid hormone metabolic process (GO:0042403)2.87410471
84fucose metabolic process (GO:0006004)2.85024245
85left/right axis specification (GO:0070986)2.85021975
86behavioral response to ethanol (GO:0048149)2.84211603
87preassembly of GPI anchor in ER membrane (GO:0016254)2.83801733
88receptor catabolic process (GO:0032801)2.83588642
89respiratory gaseous exchange (GO:0007585)2.83435906
90ethanol oxidation (GO:0006069)2.82781863
91regulation of chemokine secretion (GO:0090196)2.82516217
92regulation of interleukin-8 secretion (GO:2000482)2.82384790
93piRNA metabolic process (GO:0034587)2.81902375
94cysteine metabolic process (GO:0006534)2.81440523
95regulation of glucokinase activity (GO:0033131)2.80924727
96regulation of hexokinase activity (GO:1903299)2.80924727
97fucose catabolic process (GO:0019317)2.79964076
98L-fucose metabolic process (GO:0042354)2.79964076
99L-fucose catabolic process (GO:0042355)2.79964076
100cellular anion homeostasis (GO:0030002)2.79783680
101branching involved in labyrinthine layer morphogenesis (GO:0060670)2.79763207
102positive regulation of fatty acid transport (GO:2000193)2.79327702
103negative regulation of keratinocyte proliferation (GO:0010839)2.78348867
104cilium assembly (GO:0042384)2.78107059
105proline metabolic process (GO:0006560)2.78055442
106positive regulation of glycolytic process (GO:0045821)2.78041552
107actin filament depolymerization (GO:0030042)2.77880288
108membrane repolarization during action potential (GO:0086011)2.77564335
109cellular biogenic amine catabolic process (GO:0042402)2.77200203
110amine catabolic process (GO:0009310)2.77200203
111embryonic digestive tract morphogenesis (GO:0048557)2.76474903
112hepatocyte apoptotic process (GO:0097284)2.75395106
113retinal cone cell development (GO:0046549)2.72888180
114drug catabolic process (GO:0042737)2.72212594
115innate immune response in mucosa (GO:0002227)2.72185671
116auditory receptor cell differentiation (GO:0042491)2.70993944
117regulation of keratinocyte differentiation (GO:0045616)2.70873836
118negative regulation of systemic arterial blood pressure (GO:0003085)2.70783585
119reflex (GO:0060004)2.70749264
120flavonoid metabolic process (GO:0009812)2.70267166
121aromatic amino acid family catabolic process (GO:0009074)2.70208345
122protein localization to cilium (GO:0061512)2.70016110
123columnar/cuboidal epithelial cell development (GO:0002066)2.69052896
124cilium morphogenesis (GO:0060271)2.68199158
125DNA methylation involved in gamete generation (GO:0043046)2.67405322
126establishment of epithelial cell polarity (GO:0090162)2.67352342
127iron ion import (GO:0097286)2.66345183
128motile cilium assembly (GO:0044458)2.64817320
129sulfate transport (GO:0008272)2.64593793
130regulation of hippo signaling (GO:0035330)2.63991419
131positive regulation of icosanoid secretion (GO:0032305)2.63642957
132nephron epithelium morphogenesis (GO:0072088)2.63213557
133nephron tubule morphogenesis (GO:0072078)2.63213557
134lung alveolus development (GO:0048286)2.62643132
135sphingoid metabolic process (GO:0046519)2.62276726
136regulation of endothelial cell differentiation (GO:0045601)2.61934154
137membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.61464820
138positive regulation of endothelial cell differentiation (GO:0045603)2.61071325
139cellular ketone body metabolic process (GO:0046950)2.61002004
140prostate gland growth (GO:0060736)2.60989132
141establishment or maintenance of monopolar cell polarity (GO:0061339)2.60493227
142establishment of monopolar cell polarity (GO:0061162)2.60493227
143intestinal cholesterol absorption (GO:0030299)2.59734490
144sodium ion homeostasis (GO:0055078)2.59041870
145digestive system process (GO:0022600)2.58176248
146cellular response to reactive nitrogen species (GO:1902170)2.57808573
147regulation of cholesterol homeostasis (GO:2000188)2.57312639
148protein O-linked glycosylation (GO:0006493)2.56892799
149ventricular cardiac muscle cell action potential (GO:0086005)2.56610047
150nephron tubule formation (GO:0072079)2.56327918
151kidney morphogenesis (GO:0060993)2.55201632
152striated muscle atrophy (GO:0014891)2.54722403
153protein polyglutamylation (GO:0018095)2.54142678
154renal absorption (GO:0070293)2.54063380
155indole-containing compound metabolic process (GO:0042430)2.52289214
156organic cation transport (GO:0015695)2.52200762
157exocrine pancreas development (GO:0031017)2.51690193
158GPI anchor metabolic process (GO:0006505)2.49668444
159thyroid hormone generation (GO:0006590)2.48438527
160intraciliary transport (GO:0042073)2.47273312
161cornea development in camera-type eye (GO:0061303)2.47059025
162exogenous drug catabolic process (GO:0042738)2.47009802
163phosphatidylserine acyl-chain remodeling (GO:0036150)2.46373879
164epithelial cell maturation (GO:0002070)2.46081465
165neuronal action potential (GO:0019228)2.45619131
166positive regulation of digestive system process (GO:0060456)2.45297188
167regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.45019806
168negative regulation of cytosolic calcium ion concentration (GO:0051481)2.44704305
169protein K11-linked deubiquitination (GO:0035871)2.44650026
170positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.44462818
171positive regulation of steroid hormone secretion (GO:2000833)2.43548158
172multicellular organism reproduction (GO:0032504)2.42981911
173signal peptide processing (GO:0006465)2.41255514
174inositol phosphate-mediated signaling (GO:0048016)2.41124588
175positive regulation of prostaglandin secretion (GO:0032308)2.40700944
176branching involved in prostate gland morphogenesis (GO:0060442)2.38482495
177negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.38296856
1783-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.37639577
179purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.37639577
180ketone body metabolic process (GO:1902224)2.37034932
181regulation of microtubule-based movement (GO:0060632)2.36998645
182establishment of protein localization to Golgi (GO:0072600)2.36623223
183neural tube formation (GO:0001841)2.36344542
184nonmotile primary cilium assembly (GO:0035058)2.34937134
185prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.34900405
186diterpenoid biosynthetic process (GO:0016102)2.34900160
187mannosylation (GO:0097502)2.34687010
188retinal metabolic process (GO:0042574)2.34328847
189photoreceptor cell development (GO:0042461)2.33644041
190dopamine transport (GO:0015872)2.32666610
191surfactant homeostasis (GO:0043129)10.4471311

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.38613664
2SOX2_27498859_Chip-Seq_STOMACH_Mouse3.45572822
3CDX2_20551321_ChIP-Seq_CACO-2_Human3.45038765
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.42220121
5VDR_22108803_ChIP-Seq_LS180_Human3.23927979
6ZNF274_21170338_ChIP-Seq_K562_Hela3.22493726
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.97765839
8SOX2_20726797_ChIP-Seq_SW620_Human2.95566572
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.83905788
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.75289849
11FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.74576193
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.68662351
13GATA4_25053715_ChIP-Seq_YYC3_Human2.59152637
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.56374575
15GBX2_23144817_ChIP-Seq_PC3_Human2.55922549
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.54389439
17* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.43692921
18ZNF217_24962896_ChIP-Seq_MCF-7_Human2.41229645
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.39293843
20AHR_22903824_ChIP-Seq_MCF-7_Human2.29994527
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.29339573
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27526516
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.26086149
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.24156765
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23253083
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.22429303
27GATA6_25053715_ChIP-Seq_YYC3_Human2.20216154
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.16509715
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14787067
30POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14251821
31IGF1R_20145208_ChIP-Seq_DFB_Human2.09712836
32RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03872053
33PPAR_26484153_Chip-Seq_NCI-H1993_Human2.00542267
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98613260
35ER_23166858_ChIP-Seq_MCF-7_Human1.95953507
36RUNX1_27514584_Chip-Seq_MCF-7_Human1.94227166
37ARNT_22903824_ChIP-Seq_MCF-7_Human1.91431566
38GATA1_22025678_ChIP-Seq_K562_Human1.87913474
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87168373
40FUS_26573619_Chip-Seq_HEK293_Human1.83766508
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.83458663
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.83180052
43P300_19829295_ChIP-Seq_ESCs_Human1.78947610
44AR_21572438_ChIP-Seq_LNCaP_Human1.77262956
45ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.77095469
46LXR_22158963_ChIP-Seq_LIVER_Mouse1.73460601
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.73127543
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.71896416
49TAF15_26573619_Chip-Seq_HEK293_Human1.70917808
50EWS_26573619_Chip-Seq_HEK293_Human1.70259305
51* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.70070186
52KLF5_25053715_ChIP-Seq_YYC3_Human1.69221158
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68412964
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66927144
55SMAD4_21799915_ChIP-Seq_A2780_Human1.64822305
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.63760526
57STAT3_23295773_ChIP-Seq_U87_Human1.61404219
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60066171
59SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59940912
60AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.59647657
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58452429
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.56337241
63* AR_25329375_ChIP-Seq_VCAP_Human1.54750000
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.53592747
65* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50270016
66* CBP_20019798_ChIP-Seq_JUKART_Human1.50270016
67RACK7_27058665_Chip-Seq_MCF-7_Human1.49921737
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47402948
69TCF4_23295773_ChIP-Seq_U87_Human1.45953914
70GATA3_24758297_ChIP-Seq_MCF-7_Human1.45551592
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45488083
72FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.43114752
73TCF4_18268006_ChIP-ChIP_LS174T_Human1.43052531
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43008391
75TCF4_22108803_ChIP-Seq_LS180_Human1.42059290
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.38823949
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.38823949
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37508797
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.37264038
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36531857
81ZNF263_19887448_ChIP-Seq_K562_Human1.36365002
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.32045146
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31604886
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31292565
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30821649
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30252132
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29935813
88RUNX2_22187159_ChIP-Seq_PCA_Human1.28859341
89FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.28199116
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28137244
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27436896
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26475281
93ISL1_27105846_Chip-Seq_CPCs_Mouse1.26408970
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25970160
95SMAD4_21741376_ChIP-Seq_EPCs_Human1.25664778
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25572655
97EP300_21415370_ChIP-Seq_HL-1_Mouse1.25444682
98PPARA_22158963_ChIP-Seq_LIVER_Mouse1.25443063
99FOXA2_19822575_ChIP-Seq_HepG2_Human1.25435857
100NFE2_27457419_Chip-Seq_LIVER_Mouse1.24542220
101STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24259483
102* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24108366
103FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23344446
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.22629251
105CJUN_26792858_Chip-Seq_BT549_Human1.22455038
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.22016156
107HOXB7_26014856_ChIP-Seq_BT474_Human1.21104774
108SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20512489
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20018004
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20018004
111RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19754220
112NANOG_18555785_Chip-Seq_ESCs_Mouse1.18637865
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18505263
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18389615
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16797467
116ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16230931
117ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15390253
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15009520
119IRF1_19129219_ChIP-ChIP_H3396_Human1.14130508
120CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14048112
121FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13524415
122FOXA1_25329375_ChIP-Seq_VCAP_Human1.13524415
123RXR_22158963_ChIP-Seq_LIVER_Mouse1.13479584
124AR_20517297_ChIP-Seq_VCAP_Human1.13265139
125PIAS1_25552417_ChIP-Seq_VCAP_Human1.12956531
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12904753
127* SOX2_19829295_ChIP-Seq_ESCs_Human1.12467725
128* NANOG_19829295_ChIP-Seq_ESCs_Human1.12467725
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.10105810
130P53_22387025_ChIP-Seq_ESCs_Mouse1.10100327
131TP53_18474530_ChIP-ChIP_U2OS_Human1.09898536
132PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09806994
133PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09739461
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09543586
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08294658
136OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07938533
137RXR_22108803_ChIP-Seq_LS180_Human1.07417556
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07254870
139TP53_22573176_ChIP-Seq_HFKS_Human1.07122464
140TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05988187
141NCOR_22424771_ChIP-Seq_293T_Human1.05927663
142CLOCK_20551151_ChIP-Seq_293T_Human1.05790757
143STAT3_18555785_Chip-Seq_ESCs_Mouse1.05770230
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05168849
145SMAD3_21741376_ChIP-Seq_HESCs_Human1.04765274
146CRX_20693478_ChIP-Seq_RETINA_Mouse1.04237899
147MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04047649
148FOXA1_25552417_ChIP-Seq_VCAP_Human1.03904557
149POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02892723
150E2F1_18555785_Chip-Seq_ESCs_Mouse1.02445471
151BCAT_22108803_ChIP-Seq_LS180_Human1.01944576
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01773250
153SALL1_21062744_ChIP-ChIP_HESCs_Human0.97895740
154TBX20_22080862_ChIP-Seq_HEART_Mouse0.96215096
155TBX20_22328084_ChIP-Seq_HEART_Mouse0.96215096
156CDX2_22108803_ChIP-Seq_LS180_Human0.96038324
157SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.93549251
158TP53_16413492_ChIP-PET_HCT116_Human0.90310175
159P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88104007
160SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86631702
161STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86439127
162JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86419847
163FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.84898467
164TP63_23658742_ChIP-Seq_EP156T_Human0.82451925
165ATF3_27146783_Chip-Seq_COLON_Human0.82063337
166TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.80884090
167AR_21909140_ChIP-Seq_LNCAP_Human0.78938085
168TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78055629
169PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.76779407
170DROSHA_22980978_ChIP-Seq_HELA_Human0.75888554
171HNF4A_19822575_ChIP-Seq_HepG2_Human0.75577973
172WT1_25993318_ChIP-Seq_PODOCYTE_Human0.75369760
173ELF5_23300383_ChIP-Seq_T47D_Human0.74673942
174SMAD4_21741376_ChIP-Seq_HESCs_Human0.73925660
175CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73349688
176NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.72321126
177CREB1_26743006_Chip-Seq_LNCaP_Human0.72309734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog5.73424189
2MP0010234_abnormal_vibrissa_follicle5.06642647
3MP0000462_abnormal_digestive_system3.84283653
4MP0003195_calcinosis3.53968509
5MP0001958_emphysema3.37151021
6MP0009840_abnormal_foam_cell3.33982117
7MP0008995_early_reproductive_senescence3.29506130
8MP0008004_abnormal_stomach_pH3.18491521
9MP0000537_abnormal_urethra_morphology2.98497471
10MP0002102_abnormal_ear_morphology2.86948018
11MP0001666_abnormal_nutrient_absorption2.79484143
12MP0002876_abnormal_thyroid_physiology2.77851264
13MP0004264_abnormal_extraembryonic_tissu2.67985071
14MP0000566_synostosis2.66666077
15MP0003300_gastrointestinal_ulcer2.64608119
16MP0005360_urolithiasis2.63701659
17MP0005646_abnormal_pituitary_gland2.61650356
18MP0005551_abnormal_eye_electrophysiolog2.27343963
19MP0005083_abnormal_biliary_tract2.16366225
20MP0001177_atelectasis2.14245398
21MP0008872_abnormal_physiological_respon2.13312240
22MP0005085_abnormal_gallbladder_physiolo1.97530743
23MP0002277_abnormal_respiratory_mucosa1.87936859
24MP0004147_increased_porphyrin_level1.87075615
25MP0002132_abnormal_respiratory_system1.83660329
26MP0005645_abnormal_hypothalamus_physiol1.82247974
27MP0002736_abnormal_nociception_after1.81523750
28MP0002138_abnormal_hepatobiliary_system1.80708411
29MP0004043_abnormal_pH_regulation1.79967815
30MP0005174_abnormal_tail_pigmentation1.79904484
31MP0001664_abnormal_digestion1.76570054
32MP0001968_abnormal_touch/_nociception1.75874039
33MP0001501_abnormal_sleep_pattern1.73778422
34MP0005381_digestive/alimentary_phenotyp1.72519080
35MP0000427_abnormal_hair_cycle1.71921253
36MP0002909_abnormal_adrenal_gland1.70819225
37MP0002133_abnormal_respiratory_system1.70794867
38MP0005388_respiratory_system_phenotype1.70794867
39MP0005377_hearing/vestibular/ear_phenot1.67521171
40MP0003878_abnormal_ear_physiology1.67521171
41MP0002735_abnormal_chemical_nociception1.66230223
42MP0010678_abnormal_skin_adnexa1.65151232
43MP0002160_abnormal_reproductive_system1.64909871
44MP0005379_endocrine/exocrine_gland_phen1.64010288
45MP0008875_abnormal_xenobiotic_pharmacok1.61780734
46MP0002163_abnormal_gland_morphology1.60142665
47MP0005253_abnormal_eye_physiology1.59456396
48MP0003866_abnormal_defecation1.59387631
49MP0002928_abnormal_bile_duct1.58490634
50MP0002796_impaired_skin_barrier1.52925955
51MP0005408_hypopigmentation1.52149185
52MP0004885_abnormal_endolymph1.48973658
53MP0002098_abnormal_vibrissa_morphology1.47464598
54MP0010352_gastrointestinal_tract_polyps1.46210203
55MP0000631_abnormal_neuroendocrine_gland1.45983910
56MP0001765_abnormal_ion_homeostasis1.44392713
57MP0006054_spinal_hemorrhage1.44237453
58MP0002295_abnormal_pulmonary_circulatio1.43915841
59MP0004019_abnormal_vitamin_homeostasis1.43225379
60MP0005167_abnormal_blood-brain_barrier1.41487404
61MP0009379_abnormal_foot_pigmentation1.40916787
62MP0005310_abnormal_salivary_gland1.39719304
63MP0006072_abnormal_retinal_apoptosis1.39578601
64MP0001873_stomach_inflammation1.35795721
65MP0005389_reproductive_system_phenotype1.35754607
66MP0001663_abnormal_digestive_system1.34398520
67MP0004272_abnormal_basement_membrane1.33034067
68MP0002139_abnormal_hepatobiliary_system1.31259717
69MP0005410_abnormal_fertilization1.30239990
70MP0000613_abnormal_salivary_gland1.29757305
71MP0005084_abnormal_gallbladder_morpholo1.28132373
72MP0002060_abnormal_skin_morphology1.27391490
73MP0001919_abnormal_reproductive_system1.26228779
74MP0009046_muscle_twitch1.24979586
75MP0009643_abnormal_urine_homeostasis1.24383779
76MP0000538_abnormal_urinary_bladder1.23092487
77MP0005365_abnormal_bile_salt1.20560365
78MP0003646_muscle_fatigue1.20387594
79MP0001485_abnormal_pinna_reflex1.19862106
80MP0003950_abnormal_plasma_membrane1.18878729
81MP0003119_abnormal_digestive_system1.17769849
82MP0010155_abnormal_intestine_physiology1.16859975
83MP0006276_abnormal_autonomic_nervous1.16769369
84MP0000490_abnormal_crypts_of1.15137818
85MP0002653_abnormal_ependyma_morphology1.14556279
86MP0010368_abnormal_lymphatic_system1.14285438
87MP0008877_abnormal_DNA_methylation1.13853261
88MP0000477_abnormal_intestine_morphology1.11644527
89MP0005636_abnormal_mineral_homeostasis1.10637341
90MP0000230_abnormal_systemic_arterial1.10010375
91MP0002272_abnormal_nervous_system1.09066120
92MP0001270_distended_abdomen1.08934303
93MP0003191_abnormal_cellular_cholesterol1.06074662
94MP0005332_abnormal_amino_acid1.05954044
95MP0005670_abnormal_white_adipose1.05468853
96MP0002557_abnormal_social/conspecific_i1.05077318
97MP0000377_abnormal_hair_follicle1.04988658
98MP0003724_increased_susceptibility_to1.04806014
99MP0003315_abnormal_perineum_morphology1.03653300
100MP0001986_abnormal_taste_sensitivity1.02307257
101MP0001502_abnormal_circadian_rhythm1.01970069
102MP0001756_abnormal_urination1.00547912
103MP0001486_abnormal_startle_reflex1.00449013
104MP0010386_abnormal_urinary_bladder1.00268345
105MP0003941_abnormal_skin_development0.98772299
106MP0002733_abnormal_thermal_nociception0.97912259
107MP0003566_abnormal_cell_adhesion0.96618497
108MP0000534_abnormal_ureter_morphology0.95868700
109MP0001984_abnormal_olfaction0.94733844
110MP0003045_fibrosis0.94310086
111MP0001881_abnormal_mammary_gland0.94237408
112MP0003252_abnormal_bile_duct0.92368595
113MP0001764_abnormal_homeostasis0.91980845
114MP0004133_heterotaxia0.91879025
115MP0002136_abnormal_kidney_physiology0.91182520
116MP0002638_abnormal_pupillary_reflex0.90647802
117MP0002693_abnormal_pancreas_physiology0.90562794
118MP0001970_abnormal_pain_threshold0.89856945
119MP0005220_abnormal_exocrine_pancreas0.89128182
120MP0009745_abnormal_behavioral_response0.88969706
121MP0001944_abnormal_pancreas_morphology0.88569921
122MP0001849_ear_inflammation0.87561802
123MP0001346_abnormal_lacrimal_gland0.87047492
124MP0000647_abnormal_sebaceous_gland0.87006980
125MP0003705_abnormal_hypodermis_morpholog0.86629604
126MP0003283_abnormal_digestive_organ0.86406979
127MP0003115_abnormal_respiratory_system0.86351779
128MP0002168_other_aberrant_phenotype0.86090910
129MP0003453_abnormal_keratinocyte_physiol0.86055945
130MP0003787_abnormal_imprinting0.83189417
131MP0003183_abnormal_peptide_metabolism0.82544773
132MP0005058_abnormal_lysosome_morphology0.82194611
133MP0003698_abnormal_male_reproductive0.82034089
134MP0003953_abnormal_hormone_level0.82030253
135MP0000470_abnormal_stomach_morphology0.80732874
136MP0000627_abnormal_mammary_gland0.80337973
137MP0002837_dystrophic_cardiac_calcinosis0.80267164
138MP0002234_abnormal_pharynx_morphology0.79549988
139MP0000371_diluted_coat_color0.79428615
140MP0003943_abnormal_hepatobiliary_system0.78886143
141MP0000762_abnormal_tongue_morphology0.78818461
142MP0008057_abnormal_DNA_replication0.77893555
143MP0004145_abnormal_muscle_electrophysio0.75791525
144MP0005367_renal/urinary_system_phenotyp0.72773076
145MP0000516_abnormal_urinary_system0.72773076
146MP0008961_abnormal_basal_metabolism0.72612271
147MP0002009_preneoplasia0.72518240
148MP0004381_abnormal_hair_follicle0.72486233
149MP0001216_abnormal_epidermal_layer0.72258158
150MP0005248_abnormal_Harderian_gland0.72243282
151MP0000383_abnormal_hair_follicle0.71960845
152MP0004858_abnormal_nervous_system0.71602159
153MP0000579_abnormal_nail_morphology0.71555209
154MP0005166_decreased_susceptibility_to0.70685452
155MP0009780_abnormal_chondrocyte_physiolo0.70588867
156MP0010329_abnormal_lipoprotein_level0.69578405
157MP0004185_abnormal_adipocyte_glucose0.68752827
158MP0001175_abnormal_lung_morphology0.65231240
159MP0010771_integument_phenotype0.63343380
160MP0005501_abnormal_skin_physiology0.62383034
161MP0005275_abnormal_skin_tensile0.61567138
162MP0001879_abnormal_lymphatic_vessel0.60488881

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)7.78458534
2Hyperactive renin-angiotensin system (HP:0000841)7.63753481
3Ileus (HP:0002595)5.85750352
4Abnormality of chloride homeostasis (HP:0011422)5.45173562
5Renal salt wasting (HP:0000127)4.86449696
6Tubulointerstitial fibrosis (HP:0005576)4.85597873
7Rectal prolapse (HP:0002035)4.71675976
8Right ventricular cardiomyopathy (HP:0011663)4.69814975
9Pancreatic cysts (HP:0001737)4.47401590
10Chronic bronchitis (HP:0004469)4.26635449
11Gout (HP:0001997)4.03909621
12Hyperaldosteronism (HP:0000859)4.03777489
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.96743288
14Absent/shortened dynein arms (HP:0200106)3.96743288
15Pancreatic fibrosis (HP:0100732)3.95414998
16True hermaphroditism (HP:0010459)3.91850354
17Abnormality of midbrain morphology (HP:0002418)3.75670951
18Molar tooth sign on MRI (HP:0002419)3.75670951
19Abnormality of the renal cortex (HP:0011035)3.74513233
20Onycholysis (HP:0001806)3.70366269
21Hypokalemic alkalosis (HP:0001949)3.69571420
22Tachypnea (HP:0002789)3.57884713
23Abnormality of the renal medulla (HP:0100957)3.56323604
24Abnormal respiratory epithelium morphology (HP:0012253)3.54897466
25Abnormal respiratory motile cilium morphology (HP:0005938)3.54897466
26Abnormality of renin-angiotensin system (HP:0000847)3.51992983
27Metabolic alkalosis (HP:0200114)3.48744082
28Nephronophthisis (HP:0000090)3.45016306
29Milia (HP:0001056)3.42924691
30Abnormal ciliary motility (HP:0012262)3.29672565
31Hyperventilation (HP:0002883)3.28001905
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.17199669
33Cystic liver disease (HP:0006706)3.16105552
34Respiratory distress (HP:0002098)3.12063733
35Medial flaring of the eyebrow (HP:0010747)3.10342433
36Abnormal respiratory motile cilium physiology (HP:0012261)3.10316596
37Pili torti (HP:0003777)3.07977605
38Chronic hepatic failure (HP:0100626)3.07963510
39Congenital stationary night blindness (HP:0007642)3.04241279
40Dehydration (HP:0001944)3.02616650
41Ulnar bowing (HP:0003031)2.97297615
42Tubulointerstitial abnormality (HP:0001969)2.94982302
43Gaze-evoked nystagmus (HP:0000640)2.90856604
44Atrophic scars (HP:0001075)2.87556253
45Rhinitis (HP:0012384)2.79033319
46Abnormal drinking behavior (HP:0030082)2.77871237
47Polydipsia (HP:0001959)2.77871237
48Tubulointerstitial nephritis (HP:0001970)2.74810306
49Hypothermia (HP:0002045)2.68481696
50Hyperkalemia (HP:0002153)2.66387669
51Malnutrition (HP:0004395)2.64793785
52Potter facies (HP:0002009)2.63130624
53Facial shape deformation (HP:0011334)2.63130624
54Decreased circulating renin level (HP:0003351)2.62125306
55Esophageal varix (HP:0002040)2.61071473
56Hypotension (HP:0002615)2.60220751
57Abnormality of renal excretion (HP:0011036)2.59748410
58Widely patent fontanelles and sutures (HP:0004492)2.57251820
59Progressive hearing impairment (HP:0001730)2.54739435
60Wide cranial sutures (HP:0010537)2.53454708
61Abolished electroretinogram (ERG) (HP:0000550)2.52758430
62Type II lissencephaly (HP:0007260)2.52629973
63Hyponatremia (HP:0002902)2.41325576
64Gait imbalance (HP:0002141)2.39800235
65Glomerulosclerosis (HP:0000096)2.38222628
66Abnormal biliary tract morphology (HP:0012440)2.36893513
67Micronodular cirrhosis (HP:0001413)2.36657625
68Increased purine levels (HP:0004368)2.36216314
69Hyperuricemia (HP:0002149)2.36216314
70Congenital primary aphakia (HP:0007707)2.35477209
71Abnormality of purine metabolism (HP:0004352)2.35450503
72Conjugated hyperbilirubinemia (HP:0002908)2.35400445
73Azoospermia (HP:0000027)2.34506290
74Polyuria (HP:0000103)2.33960263
75Hypoplasia of the uterus (HP:0000013)2.32810095
76Alkalosis (HP:0001948)2.32123092
77Congenital hepatic fibrosis (HP:0002612)2.29884189
78Male pseudohermaphroditism (HP:0000037)2.29607640
79Renal cortical cysts (HP:0000803)2.28911625
80Aplasia/Hypoplasia of the tongue (HP:0010295)2.27107953
81Tubular atrophy (HP:0000092)2.27002248
82Biliary tract neoplasm (HP:0100574)2.26262880
83Congenital sensorineural hearing impairment (HP:0008527)2.25893629
84Broad-based gait (HP:0002136)2.25638523
85Absent speech (HP:0001344)2.23290787
86Nephrogenic diabetes insipidus (HP:0009806)2.22890680
87Hypoplasia of dental enamel (HP:0006297)2.20975125
88Subacute progressive viral hepatitis (HP:0006572)2.20018006
89Abdominal distention (HP:0003270)2.19835149
90Congenital, generalized hypertrichosis (HP:0004540)2.17647725
91Abnormality of the gastric mucosa (HP:0004295)2.17571729
92Abnormal rod and cone electroretinograms (HP:0008323)2.17076694
93Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16499007
94Abnormal hemoglobin (HP:0011902)2.14898584
95Attenuation of retinal blood vessels (HP:0007843)2.13575212
96Aplasia/hypoplasia of the uterus (HP:0008684)2.13033316
97Large for gestational age (HP:0001520)2.12855238
98Vascular calcification (HP:0004934)2.12564389
99Hematochezia (HP:0002573)2.12333760
100Genetic anticipation (HP:0003743)2.12058640
101Tetany (HP:0001281)2.11782927
102Visceral angiomatosis (HP:0100761)2.10398151
103Hypoplastic labia majora (HP:0000059)2.10294537
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10167330
105Abnormality of alanine metabolism (HP:0010916)2.10167330
106Hyperalaninemia (HP:0003348)2.10167330
107Decreased central vision (HP:0007663)2.09498539
108Amelogenesis imperfecta (HP:0000705)2.09109972
109Gastrointestinal dysmotility (HP:0002579)2.09045025
110Abnormality of sodium homeostasis (HP:0010931)2.08470859
111Pustule (HP:0200039)2.08466774
112Xerostomia (HP:0000217)2.07849819
113Abnormal pancreas size (HP:0012094)2.07789569
114Pendular nystagmus (HP:0012043)2.07104675
115Hypokalemia (HP:0002900)2.05870551
116Progressive cerebellar ataxia (HP:0002073)2.05442173
117Postaxial foot polydactyly (HP:0001830)2.04421843
118Partial duplication of thumb phalanx (HP:0009944)2.01994966
119Furrowed tongue (HP:0000221)2.01748363
120Ureteral obstruction (HP:0006000)2.00554811
121Mildly elevated creatine phosphokinase (HP:0008180)2.00347641
122Long toe (HP:0010511)2.00180080
123Adrenal overactivity (HP:0002717)1.99534566
124Woolly hair (HP:0002224)1.99091877
125Abnormality of potassium homeostasis (HP:0011042)1.97931324
126Polycythemia (HP:0001901)1.97921857
127Abnormal hair laboratory examination (HP:0003328)1.96690604
128Ventricular fibrillation (HP:0001663)1.95960867
129Genital tract atresia (HP:0001827)1.95372263
130Abnormality of glutamine family amino acid metabolism (HP:0010902)1.95142427
131Shawl scrotum (HP:0000049)1.95026587
132Aplasia/Hypoplasia of the tibia (HP:0005772)1.95011038
133Aortic aneurysm (HP:0004942)1.94001001
134Plantar hyperkeratosis (HP:0007556)1.93269581
135Abnormal urine output (HP:0012590)1.93213524
136Keratoconus (HP:0000563)1.93051998
137Increased corneal curvature (HP:0100692)1.93051998
138Stomach cancer (HP:0012126)1.93042482
139Cardiovascular calcification (HP:0011915)1.92910285
140Febrile seizures (HP:0002373)1.92443447
141Ureteral stenosis (HP:0000071)1.91739097
142Fragile nails (HP:0001808)1.91111385
143Bronchiectasis (HP:0002110)1.90182343
144Abnormality of the 2nd finger (HP:0004100)1.89543076
145Bowing of the arm (HP:0006488)1.89185792
146Bowed forearm bones (HP:0003956)1.89185792
147Hypomagnesemia (HP:0002917)1.88633386
148Widely spaced teeth (HP:0000687)1.88406982
149Abnormality of the labia majora (HP:0012881)1.87042239
150Sclerocornea (HP:0000647)1.86455326
151Hemangiomatosis (HP:0007461)1.86063345
152Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.85418275
153Germ cell neoplasia (HP:0100728)1.83448641
154Vaginal atresia (HP:0000148)1.83416992
155Male infertility (HP:0003251)1.83288650
156Thyroid-stimulating hormone excess (HP:0002925)1.80884466
157Abnormality of the right ventricle (HP:0001707)1.80384198
158Clumsiness (HP:0002312)1.79090975
159Femoral bowing (HP:0002980)1.79060630
160Progressive sensorineural hearing impairment (HP:0000408)1.79016980
161Pigmentary retinal degeneration (HP:0001146)1.78406915
162Hypoplastic nipples (HP:0002557)1.78096810
163Ketosis (HP:0001946)1.77095831
164Hypercalciuria (HP:0002150)1.76762736
165Focal segmental glomerulosclerosis (HP:0000097)1.76548027
166Occipital encephalocele (HP:0002085)1.75699262
167Ketoacidosis (HP:0001993)1.75579327
168Flat acetabular roof (HP:0003180)1.75416509
169Hyperglycinuria (HP:0003108)1.73891383
170Stage 5 chronic kidney disease (HP:0003774)1.73271221
171Postaxial hand polydactyly (HP:0001162)1.72659520
172Chronic sinusitis (HP:0011109)1.72030384
173Anencephaly (HP:0002323)1.71287583
174Chorioretinal atrophy (HP:0000533)1.71257751
175Aplasia cutis congenita (HP:0001057)1.71051130
176Fragile skin (HP:0001030)1.70976610

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK26.27018221
2EIF2AK14.51157553
3MST44.03641761
4FRK3.99591551
5BMPR1B3.11530184
6EPHA23.06919456
7STK392.93639762
8MST1R2.82553583
9PINK12.75045757
10MAP3K92.50082467
11ACVR1B2.41498492
12AKT32.38358129
13ADRBK22.25458998
14FGFR22.08072560
15LATS12.01474742
16MAP4K21.97223376
17TAOK31.87029552
18STK241.86262048
19WNK41.85687025
20MAP3K21.76826569
21MAP2K61.70170248
22FER1.65530552
23PTK61.65099497
24BRSK21.60828762
25PRKG21.60284214
26EPHB21.59385141
27OXSR11.56772257
28LRRK21.55379984
29TLK11.51417242
30CASK1.50909897
31RIPK11.49475902
32MET1.45062131
33ZAK1.36794540
34MAPK131.35719554
35MAPK151.34972304
36WNK31.34530700
37FGFR41.31264006
38MYLK1.30516518
39EPHB11.29683295
40MAP2K21.28844044
41TESK11.20709103
42TGFBR21.19348196
43PAK31.15819141
44DAPK21.13471871
45STK38L1.13075357
46NLK1.12669251
47PDK21.12070117
48DDR21.11507505
49SIK11.10840155
50TNK21.02260918
51STK101.01794711
52PRKCE1.00597804
53ERBB20.98599565
54NUAK10.98597681
55EEF2K0.97648778
56MAP3K40.92625261
57TAF10.92407706
58ZAP700.91599805
59MAP3K30.91122980
60TNIK0.88167604
61IRAK10.87509886
62PTK20.86026572
63MAP3K70.84240709
64PAK40.84130793
65ERN10.83668878
66CAMK1D0.83559831
67BCR0.83499922
68PDGFRB0.82374646
69CAMKK20.81909080
70RPS6KB20.81834359
71MUSK0.79935431
72TIE10.79116100
73TBK10.78190514
74CSNK1G10.76128307
75PRKAA20.75885184
76BCKDK0.73737750
77EIF2AK30.72533473
78MAPKAPK50.71945885
79EPHA30.71299945
80GRK10.69224983
81IKBKB0.65740903
82ADRBK10.65698096
83PRKAA10.62560796
84PKN20.61551035
85TRIB30.61451908
86PNCK0.61175425
87CSNK1A10.60817573
88PIK3CA0.60207072
89ERBB30.60185602
90CDK60.59543792
91STK30.59192202
92CSNK1A1L0.59170384
93ARAF0.58493783
94MAP2K70.58066739
95PHKG20.57463066
96PHKG10.57463066
97TRPM70.56112524
98PDPK10.55343917
99PRKCQ0.54327964
100TEC0.52097502
101TXK0.50845455
102KSR20.49749163
103CSNK1G30.49370445
104PTK2B0.49279519
105PRKCI0.47915441
106VRK10.47750657
107MKNK20.47684096
108GSK3A0.47578352
109NME10.47423251
110IRAK30.46123835
111IKBKE0.45342807
112NTRK30.44803868
113DMPK0.44786776
114PIK3CG0.44403268
115PDGFRA0.44280056
116GRK60.43531287
117SCYL20.41149698
118ROCK10.41056469
119MAP3K100.40906858
120INSRR0.40025653
121CSNK1G20.39977049
122PRKCG0.38631362
123FGFR30.37810032
124STK380.37434353
125PDK30.36541192
126PDK40.36541192
127PRKACA0.36528217
128PRKG10.35156844
129CAMK10.35023149
130IGF1R0.34644200
131MAP2K10.34621656
132CDK30.34043928
133KIT0.34030888
134SGK10.33882428
135STK110.33846581
136PRKCA0.33683459
137MAP3K80.32926558
138BMX0.30929495
139PRKD10.30909963
140RPS6KA20.30524313
141SGK30.30363852
142PRKCZ0.29719682
143MAP3K10.28414091
144CAMK1G0.27207964
145CHUK0.25980123
146TTN0.23538481
147DYRK1B0.22380347
148MATK0.22051862
149ILK0.21663451
150SGK2230.21586576
151SGK4940.21586576
152SGK20.20567656
153EGFR0.20017061
154MAPKAPK30.19808178
155FGFR10.19467388
156HIPK20.19290528

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049784.23795620
2Sulfur metabolism_Homo sapiens_hsa009203.53374564
3Linoleic acid metabolism_Homo sapiens_hsa005912.46115455
4Renin-angiotensin system_Homo sapiens_hsa046142.38543385
5Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.33310071
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.28998173
7Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.24724548
8Butanoate metabolism_Homo sapiens_hsa006502.18015990
9Caffeine metabolism_Homo sapiens_hsa002322.08689526
10Histidine metabolism_Homo sapiens_hsa003402.06347050
11Fat digestion and absorption_Homo sapiens_hsa049752.04189473
12Tight junction_Homo sapiens_hsa045302.03462290
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.98064266
14Protein digestion and absorption_Homo sapiens_hsa049741.96926465
15Phototransduction_Homo sapiens_hsa047441.95218438
16Fatty acid biosynthesis_Homo sapiens_hsa000611.90551251
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.86937490
18Adherens junction_Homo sapiens_hsa045201.81476964
19Fatty acid degradation_Homo sapiens_hsa000711.66250127
20Pancreatic secretion_Homo sapiens_hsa049721.64295720
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64019723
22Bile secretion_Homo sapiens_hsa049761.63042804
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57617922
24Vibrio cholerae infection_Homo sapiens_hsa051101.55360052
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54168624
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.51163755
27ECM-receptor interaction_Homo sapiens_hsa045121.50681322
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50566980
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48927662
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48453646
31Gastric acid secretion_Homo sapiens_hsa049711.45432345
32Thyroid hormone synthesis_Homo sapiens_hsa049181.44200048
33Other glycan degradation_Homo sapiens_hsa005111.43844182
34Vitamin digestion and absorption_Homo sapiens_hsa049771.43743355
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.43437611
36ABC transporters_Homo sapiens_hsa020101.41288994
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39869211
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.36740979
39Selenocompound metabolism_Homo sapiens_hsa004501.35301224
40Glutathione metabolism_Homo sapiens_hsa004801.30610986
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28256347
42Hepatitis C_Homo sapiens_hsa051601.24805253
43beta-Alanine metabolism_Homo sapiens_hsa004101.24448647
44Peroxisome_Homo sapiens_hsa041461.23912708
45Nicotine addiction_Homo sapiens_hsa050331.17680276
46Protein export_Homo sapiens_hsa030601.16784991
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13103241
48Tryptophan metabolism_Homo sapiens_hsa003801.05325561
49Arginine and proline metabolism_Homo sapiens_hsa003301.04780091
50Olfactory transduction_Homo sapiens_hsa047401.04583110
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.03543468
52Hippo signaling pathway_Homo sapiens_hsa043901.02536653
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02248012
54Ovarian steroidogenesis_Homo sapiens_hsa049131.02128490
55Glycerolipid metabolism_Homo sapiens_hsa005611.01920396
56Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00649914
57Insulin secretion_Homo sapiens_hsa049110.96873190
58Circadian rhythm_Homo sapiens_hsa047100.96229558
59Bladder cancer_Homo sapiens_hsa052190.92727021
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92458815
61Oxidative phosphorylation_Homo sapiens_hsa001900.89946105
62Taste transduction_Homo sapiens_hsa047420.89591113
63Pertussis_Homo sapiens_hsa051330.87010587
64Regulation of autophagy_Homo sapiens_hsa041400.86677232
65Chemical carcinogenesis_Homo sapiens_hsa052040.86217448
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86017693
67Basal transcription factors_Homo sapiens_hsa030220.85309649
68Salivary secretion_Homo sapiens_hsa049700.84609533
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83723569
70Pyruvate metabolism_Homo sapiens_hsa006200.80953699
71Fructose and mannose metabolism_Homo sapiens_hsa000510.80484615
72Nitrogen metabolism_Homo sapiens_hsa009100.80244219
73Serotonergic synapse_Homo sapiens_hsa047260.79228158
74Sphingolipid metabolism_Homo sapiens_hsa006000.79028692
75N-Glycan biosynthesis_Homo sapiens_hsa005100.77850695
76Retinol metabolism_Homo sapiens_hsa008300.76128396
77Tyrosine metabolism_Homo sapiens_hsa003500.75212432
78Asthma_Homo sapiens_hsa053100.74047056
79Lysosome_Homo sapiens_hsa041420.73693086
80Fanconi anemia pathway_Homo sapiens_hsa034600.73302344
81Amoebiasis_Homo sapiens_hsa051460.72822475
82Arachidonic acid metabolism_Homo sapiens_hsa005900.72396772
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72306140
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71778991
85Focal adhesion_Homo sapiens_hsa045100.70532062
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69686989
87Starch and sucrose metabolism_Homo sapiens_hsa005000.69494353
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68373418
89RNA polymerase_Homo sapiens_hsa030200.67990624
90Dorso-ventral axis formation_Homo sapiens_hsa043200.67612861
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.67131469
92Influenza A_Homo sapiens_hsa051640.65988245
93Endometrial cancer_Homo sapiens_hsa052130.63989281
94Propanoate metabolism_Homo sapiens_hsa006400.63273393
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63046503
96Huntingtons disease_Homo sapiens_hsa050160.62845067
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62088612
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60909410
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60753620
100Toxoplasmosis_Homo sapiens_hsa051450.60744427
101Galactose metabolism_Homo sapiens_hsa000520.60090981
102Small cell lung cancer_Homo sapiens_hsa052220.59954016
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59579469
104Homologous recombination_Homo sapiens_hsa034400.58918228
105Morphine addiction_Homo sapiens_hsa050320.58067487
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57641019
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.54999410
108Rap1 signaling pathway_Homo sapiens_hsa040150.53904377
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53877879
110Ether lipid metabolism_Homo sapiens_hsa005650.53085550
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53027163
112Glutamatergic synapse_Homo sapiens_hsa047240.53025275
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52536696
114Salmonella infection_Homo sapiens_hsa051320.52375018
115Circadian entrainment_Homo sapiens_hsa047130.52310046
116Metabolic pathways_Homo sapiens_hsa011000.51063996
117Thyroid cancer_Homo sapiens_hsa052160.49650112
118Fatty acid metabolism_Homo sapiens_hsa012120.48587152
119Proteoglycans in cancer_Homo sapiens_hsa052050.48042782
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.47194306
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45556786
122Cocaine addiction_Homo sapiens_hsa050300.44989095
123PPAR signaling pathway_Homo sapiens_hsa033200.44748771
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43786584
125Calcium signaling pathway_Homo sapiens_hsa040200.43571966
126Inositol phosphate metabolism_Homo sapiens_hsa005620.41736985
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41397188
128Folate biosynthesis_Homo sapiens_hsa007900.41121029
129Pancreatic cancer_Homo sapiens_hsa052120.40844468
130Prolactin signaling pathway_Homo sapiens_hsa049170.40803628
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40781006
132Long-term depression_Homo sapiens_hsa047300.39286574
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.36256095
134Phenylalanine metabolism_Homo sapiens_hsa003600.35506389
135Amphetamine addiction_Homo sapiens_hsa050310.35182979
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35126932
137Rheumatoid arthritis_Homo sapiens_hsa053230.34123710
138Melanoma_Homo sapiens_hsa052180.33737711
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33164578
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32699386
141Renin secretion_Homo sapiens_hsa049240.31580362
142Platelet activation_Homo sapiens_hsa046110.31560018
143Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31318169
144Collecting duct acid secretion_Homo sapiens_hsa049660.31223295
145Insulin resistance_Homo sapiens_hsa049310.30261732
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29512449
147NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29348677
148Prostate cancer_Homo sapiens_hsa052150.28388114
149FoxO signaling pathway_Homo sapiens_hsa040680.27767751

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