ARHGEF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The protein encoded by this gene may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of some variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.50074936
2synaptic vesicle maturation (GO:0016188)6.28176667
3locomotory exploration behavior (GO:0035641)6.10481060
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.91629067
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.53968548
6synaptic vesicle exocytosis (GO:0016079)5.49644563
7vocalization behavior (GO:0071625)5.48053521
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.39842900
9glutamate secretion (GO:0014047)5.33474116
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.22703627
11regulation of glutamate receptor signaling pathway (GO:1900449)5.21417948
12regulation of synaptic vesicle exocytosis (GO:2000300)5.09113250
13axon ensheathment in central nervous system (GO:0032291)4.96179787
14central nervous system myelination (GO:0022010)4.96179787
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.93155731
16neuronal action potential propagation (GO:0019227)4.90286226
17regulation of neuronal synaptic plasticity (GO:0048168)4.89024065
18protein localization to synapse (GO:0035418)4.77442578
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.76098277
20exploration behavior (GO:0035640)4.68410759
21neurotransmitter secretion (GO:0007269)4.68090017
22regulation of synaptic vesicle transport (GO:1902803)4.63063500
23regulation of synapse structural plasticity (GO:0051823)4.43648001
24synaptic transmission, glutamatergic (GO:0035249)4.40528548
25neuron cell-cell adhesion (GO:0007158)4.36154441
26neurotransmitter-gated ion channel clustering (GO:0072578)4.34296243
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.29637829
28long-term memory (GO:0007616)4.28641728
29glutamate receptor signaling pathway (GO:0007215)4.24505184
30cellular potassium ion homeostasis (GO:0030007)4.23341078
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.20115965
32dendritic spine morphogenesis (GO:0060997)4.18914431
33cerebellar granule cell differentiation (GO:0021707)4.18540267
34gamma-aminobutyric acid transport (GO:0015812)4.17329452
35neuron-neuron synaptic transmission (GO:0007270)4.08093180
36layer formation in cerebral cortex (GO:0021819)4.07128708
37potassium ion homeostasis (GO:0055075)4.01953926
38positive regulation of membrane potential (GO:0045838)3.98310445
39sodium ion export (GO:0071436)3.98154997
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.88745082
41L-amino acid import (GO:0043092)3.85155355
42regulation of synaptic plasticity (GO:0048167)3.81945088
43neurotransmitter transport (GO:0006836)3.81204132
44proline transport (GO:0015824)3.80074864
45regulation of postsynaptic membrane potential (GO:0060078)3.68411392
46positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.64805605
47neuromuscular process controlling posture (GO:0050884)3.64110273
48long-term synaptic potentiation (GO:0060291)3.63368692
49neuromuscular process controlling balance (GO:0050885)3.61925260
50regulation of dendritic spine morphogenesis (GO:0061001)3.60984834
51transmission of nerve impulse (GO:0019226)3.60813844
52positive regulation of synaptic transmission, GABAergic (GO:0032230)3.58998064
53regulation of voltage-gated calcium channel activity (GO:1901385)3.58523187
54response to auditory stimulus (GO:0010996)3.54847252
55regulation of neurotransmitter levels (GO:0001505)3.54509417
56regulation of vesicle fusion (GO:0031338)3.51651600
57activation of protein kinase A activity (GO:0034199)3.51598058
58glycine transport (GO:0015816)3.50392857
59regulation of neurotransmitter secretion (GO:0046928)3.50004425
60positive regulation of synapse maturation (GO:0090129)3.47432301
61synaptic vesicle endocytosis (GO:0048488)3.47367919
62auditory behavior (GO:0031223)3.46680440
63positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.44585023
64regulation of synapse maturation (GO:0090128)3.44531080
65negative regulation of synaptic transmission, GABAergic (GO:0032229)3.43833279
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.40768187
67postsynaptic membrane organization (GO:0001941)3.40109308
68cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.39446385
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.39228131
70neuron recognition (GO:0008038)3.38480481
71neurotransmitter uptake (GO:0001504)3.35179521
72G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.35097781
73positive regulation of neurotransmitter transport (GO:0051590)3.34334652
74cell communication by electrical coupling (GO:0010644)3.34100749
75negative regulation of dendrite morphogenesis (GO:0050774)3.33719777
76presynaptic membrane organization (GO:0097090)3.33262297
77neuronal ion channel clustering (GO:0045161)3.32692834
78regulation of neurotransmitter transport (GO:0051588)3.32074887
79acidic amino acid transport (GO:0015800)3.31252291
80cerebellar Purkinje cell differentiation (GO:0021702)3.31158692
81regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.30134396
82prepulse inhibition (GO:0060134)3.30068905
83positive regulation of neurotransmitter secretion (GO:0001956)3.29589947
84cellular sodium ion homeostasis (GO:0006883)3.28213376
85innervation (GO:0060384)3.26037282
86positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.25535140
87gamma-aminobutyric acid signaling pathway (GO:0007214)3.23369614
88membrane hyperpolarization (GO:0060081)3.21095656
89dendrite morphogenesis (GO:0048813)3.20157385
90positive regulation of synaptic transmission (GO:0050806)3.18440018
91membrane depolarization (GO:0051899)3.18136909
92amino acid import (GO:0043090)3.17497041
93cell communication involved in cardiac conduction (GO:0086065)3.16895204
94membrane depolarization during action potential (GO:0086010)3.15831842
95learning (GO:0007612)3.14817268
96axonal fasciculation (GO:0007413)3.14565144
97positive regulation of dendritic spine morphogenesis (GO:0061003)3.12217310
98cytoskeletal anchoring at plasma membrane (GO:0007016)3.11883920
99regulation of synaptic transmission (GO:0050804)3.11873966
100neuromuscular synaptic transmission (GO:0007274)3.10851549
101positive regulation of dendritic spine development (GO:0060999)3.10219473
102dendritic spine organization (GO:0097061)3.09937970
103chemosensory behavior (GO:0007635)3.08600673
104behavioral defense response (GO:0002209)3.06765507
105behavioral fear response (GO:0001662)3.06765507
106regulation of dendritic spine development (GO:0060998)3.05384172
107regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04346910
108synaptic transmission (GO:0007268)3.04302332
109potassium ion import (GO:0010107)3.03520086
110neuromuscular process (GO:0050905)3.02684054
111cell migration in hindbrain (GO:0021535)2.99876009
112G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.97634410
113social behavior (GO:0035176)2.97082920
114intraspecies interaction between organisms (GO:0051703)2.97082920
115regulation of ARF protein signal transduction (GO:0032012)2.97022236
116vesicle transport along microtubule (GO:0047496)2.96828163
117presynaptic membrane assembly (GO:0097105)2.95457577
118L-glutamate transport (GO:0015813)2.94528621
119positive regulation of dendrite development (GO:1900006)2.87359650
120establishment of mitochondrion localization (GO:0051654)2.78727548

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.21340639
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.23817287
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21422285
4GBX2_23144817_ChIP-Seq_PC3_Human3.17974342
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12941643
6REST_21632747_ChIP-Seq_MESCs_Mouse2.86662410
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.85807937
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.83863012
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.83863012
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.82545932
11* RARB_27405468_Chip-Seq_BRAIN_Mouse2.81049827
12DROSHA_22980978_ChIP-Seq_HELA_Human2.71138494
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69983116
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.66334702
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.62042890
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.61504318
17* EZH2_27304074_Chip-Seq_ESCs_Mouse2.55051344
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51618677
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40748387
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.38610255
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.37045696
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.35708110
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.34227934
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.29131955
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.27999544
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.18570757
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07422499
28AR_21572438_ChIP-Seq_LNCaP_Human2.06887401
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00302579
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.96627452
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87985049
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.75597356
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71169359
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58191197
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55517313
36SMAD4_21799915_ChIP-Seq_A2780_Human1.53174546
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49250826
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.45898663
39RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41083868
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38218542
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.35885759
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31556553
43TAF15_26573619_Chip-Seq_HEK293_Human1.30653733
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29249494
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28856851
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28174041
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27154094
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.26696841
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25398725
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22738741
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.22379100
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.21688302
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21080738
54OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20186339
55AR_25329375_ChIP-Seq_VCAP_Human1.20146993
56AR_19668381_ChIP-Seq_PC3_Human1.19095859
57ZNF274_21170338_ChIP-Seq_K562_Hela1.17848055
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17641276
59P300_19829295_ChIP-Seq_ESCs_Human1.17336417
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15810220
61KDM2B_26808549_Chip-Seq_K562_Human1.14471852
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.13815488
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13148330
64* CBX2_27304074_Chip-Seq_ESCs_Mouse1.12099483
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10875819
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10198813
67* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09939884
68* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09405815
69STAT3_23295773_ChIP-Seq_U87_Human1.09067390
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06606561
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04592810
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04203249
73RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04118182
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03911528
75LXR_22292898_ChIP-Seq_THP-1_Human1.03715167
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03610193
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03166860
78SMC4_20622854_ChIP-Seq_HELA_Human1.02710466
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01743324
80BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99472400
81YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98368748
82SMAD3_21741376_ChIP-Seq_ESCs_Human0.98358556
83ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97792641
84RNF2_27304074_Chip-Seq_NSC_Mouse0.97627155
85PIAS1_25552417_ChIP-Seq_VCAP_Human0.97284168
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96566753
87CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95842379
88ARNT_22903824_ChIP-Seq_MCF-7_Human0.95676664
89* TCF4_23295773_ChIP-Seq_U87_Human0.95348640
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94687043
91AHR_22903824_ChIP-Seq_MCF-7_Human0.93886762
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93783576
93OCT4_19829295_ChIP-Seq_ESCs_Human0.93474473
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93362678
95* SMAD3_21741376_ChIP-Seq_HESCs_Human0.93347743
96RXR_22108803_ChIP-Seq_LS180_Human0.92989063
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92789295
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.92029910
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91386579
100TP53_16413492_ChIP-PET_HCT116_Human0.91258043
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91125490
102RUNX2_22187159_ChIP-Seq_PCA_Human0.90890468
103GATA1_26923725_Chip-Seq_HPCs_Mouse0.90611324
104CTCF_27219007_Chip-Seq_Bcells_Human0.89386787
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89374287
106KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89155199
107CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87950515
108TET1_21490601_ChIP-Seq_MESCs_Mouse0.87632457
109* SMAD4_21741376_ChIP-Seq_HESCs_Human0.86610473
110EGR1_19032775_ChIP-ChIP_M12_Human0.86274445
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86225881
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85002893
113SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84415990
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84042018
115* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83531286
116TRIM28_21343339_ChIP-Seq_HEK293_Human0.83453673
117KLF4_19829295_ChIP-Seq_ESCs_Human0.83348004
118EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83205082
119* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82868720
120SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82557117
121TP53_23651856_ChIP-Seq_MEFs_Mouse0.82279347
122P68_20966046_ChIP-Seq_HELA_Human0.81991389
123CREB1_26743006_Chip-Seq_LNCaP_Human0.81896776
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80867442
125TP53_20018659_ChIP-ChIP_R1E_Mouse0.79491966
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79249555
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79203201
128SMAD4_21741376_ChIP-Seq_ESCs_Human0.78924238
129* TP63_22573176_ChIP-Seq_HFKS_Human0.78575718
130SRY_22984422_ChIP-ChIP_TESTIS_Rat0.73629472
131* DPY_21335234_ChIP-Seq_ESCs_Mouse0.72072112
132RUNX1_26923725_Chip-Seq_HPCs_Mouse0.72025215

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.03641530
2MP0003880_abnormal_central_pattern5.05861138
3MP0003635_abnormal_synaptic_transmissio4.27538272
4MP0004270_analgesia3.55444916
5MP0009745_abnormal_behavioral_response3.54636557
6MP0002063_abnormal_learning/memory/cond3.39331477
7MP0002064_seizures3.29192988
8MP0000579_abnormal_nail_morphology3.12683257
9MP0009046_muscle_twitch3.11571771
10MP0002822_catalepsy3.10773168
11MP0001968_abnormal_touch/_nociception3.04766552
12MP0005423_abnormal_somatic_nervous3.03784720
13MP0002572_abnormal_emotion/affect_behav2.80309078
14MP0001486_abnormal_startle_reflex2.76717890
15MP0002272_abnormal_nervous_system2.66054354
16MP0002734_abnormal_mechanical_nocicepti2.53600608
17MP0001501_abnormal_sleep_pattern2.36350871
18MP0002736_abnormal_nociception_after2.25777575
19MP0002735_abnormal_chemical_nociception2.11069240
20MP0001440_abnormal_grooming_behavior2.09141791
21MP0008569_lethality_at_weaning2.01297941
22MP0002733_abnormal_thermal_nociception1.97873371
23MP0004858_abnormal_nervous_system1.96234663
24MP0001970_abnormal_pain_threshold1.95836918
25MP0002067_abnormal_sensory_capabilities1.94632248
26MP0009780_abnormal_chondrocyte_physiolo1.93088546
27MP0005646_abnormal_pituitary_gland1.79052547
28MP0002557_abnormal_social/conspecific_i1.78146831
29MP0004811_abnormal_neuron_physiology1.77555773
30MP0000778_abnormal_nervous_system1.70537485
31MP0003329_amyloid_beta_deposits1.69657065
32MP0002184_abnormal_innervation1.66751064
33MP0002909_abnormal_adrenal_gland1.65871263
34MP0004885_abnormal_endolymph1.63998901
35MP0004924_abnormal_behavior1.63135312
36MP0005386_behavior/neurological_phenoty1.63135312
37MP0000955_abnormal_spinal_cord1.60903521
38MP0000566_synostosis1.60239585
39MP0003787_abnormal_imprinting1.58789885
40MP0005645_abnormal_hypothalamus_physiol1.55488703
41MP0003879_abnormal_hair_cell1.53426879
42MP0006276_abnormal_autonomic_nervous1.49226850
43MP0002882_abnormal_neuron_morphology1.42835129
44MP0001984_abnormal_olfaction1.42544954
45MP0004142_abnormal_muscle_tone1.40123537
46MP0002066_abnormal_motor_capabilities/c1.39946747
47MP0003633_abnormal_nervous_system1.38323555
48MP0001502_abnormal_circadian_rhythm1.34622476
49MP0001905_abnormal_dopamine_level1.25512906
50MP0001529_abnormal_vocalization1.24568868
51MP0001188_hyperpigmentation1.17794890
52MP0003122_maternal_imprinting1.15862931
53MP0003690_abnormal_glial_cell1.15567136
54MP0003631_nervous_system_phenotype1.14041243
55MP0002152_abnormal_brain_morphology1.10125772
56MP0003123_paternal_imprinting1.06692707
57MP0001177_atelectasis1.00543892
58MP0003075_altered_response_to0.98844958
59MP0008872_abnormal_physiological_respon0.96607819
60MP0000569_abnormal_digit_pigmentation0.95422253
61MP0000751_myopathy0.94805847
62MP0001346_abnormal_lacrimal_gland0.92290410
63MP0002069_abnormal_eating/drinking_beha0.92031575
64MP0002229_neurodegeneration0.91861446
65MP0003634_abnormal_glial_cell0.91696366
66MP0008874_decreased_physiological_sensi0.88946798
67MP0008961_abnormal_basal_metabolism0.88379510
68MP0004742_abnormal_vestibular_system0.87321592
69MP0005551_abnormal_eye_electrophysiolog0.86361075
70MP0000920_abnormal_myelination0.86064200
71MP0005167_abnormal_blood-brain_barrier0.85778279
72MP0005394_taste/olfaction_phenotype0.83926672
73MP0005499_abnormal_olfactory_system0.83926672
74MP0003283_abnormal_digestive_organ0.83222829
75MP0001963_abnormal_hearing_physiology0.82556566
76MP0002653_abnormal_ependyma_morphology0.82438784
77MP0005409_darkened_coat_color0.81777900
78MP0002234_abnormal_pharynx_morphology0.79969129
79MP0000383_abnormal_hair_follicle0.79496255
80MP0010386_abnormal_urinary_bladder0.78876974
81MP0002638_abnormal_pupillary_reflex0.78071369
82MP0003632_abnormal_nervous_system0.77731135
83MP0001485_abnormal_pinna_reflex0.77375816
84MP0005377_hearing/vestibular/ear_phenot0.76373717
85MP0003878_abnormal_ear_physiology0.76373717
86MP0000013_abnormal_adipose_tissue0.75513720
87MP0000762_abnormal_tongue_morphology0.75279019
88MP0002796_impaired_skin_barrier0.74920477
89MP0000631_abnormal_neuroendocrine_gland0.74173044
90MP0002752_abnormal_somatic_nervous0.73522822
91MP0010678_abnormal_skin_adnexa0.72800296
92MP0004145_abnormal_muscle_electrophysio0.70221441
93MP0000604_amyloidosis0.68516421
94MP0005535_abnormal_body_temperature0.68232865
95MP0004085_abnormal_heartbeat0.67061300
96MP0009379_abnormal_foot_pigmentation0.65613497
97MP0001986_abnormal_taste_sensitivity0.65330326
98MP0005623_abnormal_meninges_morphology0.65088918
99MP0001348_abnormal_lacrimal_gland0.64671950
100MP0002090_abnormal_vision0.64070089
101MP0010771_integument_phenotype0.62663333
102MP0000467_abnormal_esophagus_morphology0.61485279
103MP0002249_abnormal_larynx_morphology0.59144386
104MP0001664_abnormal_digestion0.59023252
105MP0003137_abnormal_impulse_conducting0.58584244
106MP0000427_abnormal_hair_cycle0.57266277
107MP0001943_abnormal_respiration0.56062982
108MP0004215_abnormal_myocardial_fiber0.55229151
109MP0003861_abnormal_nervous_system0.54858254
110MP0010769_abnormal_survival0.53907525
111MP0004133_heterotaxia0.53529939
112MP0004130_abnormal_muscle_cell0.53473215
113MP0010234_abnormal_vibrissa_follicle0.53443978
114MP0010768_mortality/aging0.50997695
115MP0010770_preweaning_lethality0.50287301
116MP0002082_postnatal_lethality0.50287301
117MP0001299_abnormal_eye_distance/0.49775868
118MP0004233_abnormal_muscle_weight0.49509584
119MP0003172_abnormal_lysosome_physiology0.49351439
120MP0003956_abnormal_body_size0.49018299
121MP0000026_abnormal_inner_ear0.48711938

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.24922223
2Myokymia (HP:0002411)7.73677213
3Focal seizures (HP:0007359)5.98395292
4Visual hallucinations (HP:0002367)5.27877740
5Epileptic encephalopathy (HP:0200134)4.74482038
6Febrile seizures (HP:0002373)4.69490954
7Atonic seizures (HP:0010819)4.52613683
8Progressive cerebellar ataxia (HP:0002073)4.47100808
9Absence seizures (HP:0002121)4.18878628
10Action tremor (HP:0002345)4.04833613
11Generalized tonic-clonic seizures (HP:0002069)4.00728369
12Dialeptic seizures (HP:0011146)3.86778090
13Supranuclear gaze palsy (HP:0000605)3.78101774
14Ankle clonus (HP:0011448)3.67316481
15Impaired vibration sensation in the lower limbs (HP:0002166)3.44490109
16Depression (HP:0000716)3.38638342
17Poor eye contact (HP:0000817)3.35460024
18Broad-based gait (HP:0002136)3.34919858
19Abnormal eating behavior (HP:0100738)3.30598412
20Dysdiadochokinesis (HP:0002075)3.24169386
21Gaze-evoked nystagmus (HP:0000640)3.23635764
22Abnormality of nail color (HP:0100643)3.21899434
23Split foot (HP:0001839)3.16159632
24Urinary bladder sphincter dysfunction (HP:0002839)3.15042620
25Postural instability (HP:0002172)3.14928772
26Megalencephaly (HP:0001355)3.12988071
27Dysmetria (HP:0001310)3.11279240
28Anxiety (HP:0000739)3.04747703
29Abnormal social behavior (HP:0012433)3.02725141
30Impaired social interactions (HP:0000735)3.02725141
31Truncal ataxia (HP:0002078)2.92553839
32Mutism (HP:0002300)2.89883190
33Urinary urgency (HP:0000012)2.81489863
34Hemiplegia (HP:0002301)2.81011307
35Genetic anticipation (HP:0003743)2.79226937
36Amblyopia (HP:0000646)2.78070870
37Ventricular fibrillation (HP:0001663)2.76037579
38Hemiparesis (HP:0001269)2.75539175
39Torticollis (HP:0000473)2.75309450
40Papilledema (HP:0001085)2.74703751
41Scanning speech (HP:0002168)2.70246430
42Akinesia (HP:0002304)2.68206039
43Intention tremor (HP:0002080)2.60638767
44Focal dystonia (HP:0004373)2.59213501
45Diplopia (HP:0000651)2.58944004
46Abnormality of binocular vision (HP:0011514)2.58944004
47Hyperventilation (HP:0002883)2.58046116
48Impaired smooth pursuit (HP:0007772)2.57647153
49Annular pancreas (HP:0001734)2.57374583
50Spastic gait (HP:0002064)2.57034024
51Tetraplegia (HP:0002445)2.55482831
52Plantar hyperkeratosis (HP:0007556)2.53198039
53Cerebral hypomyelination (HP:0006808)2.52944909
54Bradykinesia (HP:0002067)2.52313076
55Stereotypic behavior (HP:0000733)2.51652863
56Onycholysis (HP:0001806)2.47725806
57Milia (HP:0001056)2.47657860
58Abnormality of the lower motor neuron (HP:0002366)2.46945426
59Fetal akinesia sequence (HP:0001989)2.44093128
60Abnormality of the corticospinal tract (HP:0002492)2.41679806
61Peripheral hypomyelination (HP:0007182)2.41609158
62Drooling (HP:0002307)2.39132150
63Excessive salivation (HP:0003781)2.39132150
64Fragile nails (HP:0001808)2.38721310
65Progressive inability to walk (HP:0002505)2.38253851
66Aplasia involving bones of the extremities (HP:0009825)2.36265848
67Aplasia involving bones of the upper limbs (HP:0009823)2.36265848
68Aplasia of the phalanges of the hand (HP:0009802)2.36265848
69Impaired vibratory sensation (HP:0002495)2.32326054
70Pointed chin (HP:0000307)2.30919787
71Polyphagia (HP:0002591)2.27475639
72Craniofacial dystonia (HP:0012179)2.26362318
73Abnormality of ocular smooth pursuit (HP:0000617)2.24966946
74Obstructive sleep apnea (HP:0002870)2.24584837
75Status epilepticus (HP:0002133)2.23700492
76Neurofibrillary tangles (HP:0002185)2.22726148
77Insomnia (HP:0100785)2.22195505
78Bronchomalacia (HP:0002780)2.21385938
79Spastic tetraparesis (HP:0001285)2.18735230
80Palmoplantar hyperkeratosis (HP:0000972)2.17053031
81Lower limb muscle weakness (HP:0007340)2.14826126
82Epileptiform EEG discharges (HP:0011182)2.12637832
83Apathy (HP:0000741)2.09543729
84Bundle branch block (HP:0011710)2.05851538
85Cerebral inclusion bodies (HP:0100314)2.04933281
86EEG with generalized epileptiform discharges (HP:0011198)2.04208651
87Palmar hyperkeratosis (HP:0010765)2.03698185
88Increased circulating renin level (HP:0000848)2.00527081
89Incomplete penetrance (HP:0003829)1.98364352
90Limb dystonia (HP:0002451)1.97585029
91Absent speech (HP:0001344)1.97259070
92Turricephaly (HP:0000262)1.96722928
93Dysmetric saccades (HP:0000641)1.96485154
94Hypsarrhythmia (HP:0002521)1.95603176
95Generalized myoclonic seizures (HP:0002123)1.95021633
96Abnormal EKG (HP:0003115)1.92918858
97Sleep apnea (HP:0010535)1.89894442
98Delusions (HP:0000746)1.89774538
99Gait ataxia (HP:0002066)1.88470838
100Clonus (HP:0002169)1.87788647
101Thick nail (HP:0001805)1.85020688
102Inability to walk (HP:0002540)1.84992728
103Pili torti (HP:0003777)1.84268656
104Abnormality of the salivary glands (HP:0010286)1.83782853
105Lower limb amyotrophy (HP:0007210)1.83399799
106Diminished motivation (HP:0000745)1.82327141
107Abnormality of saccadic eye movements (HP:0000570)1.81953226
108Neuronal loss in central nervous system (HP:0002529)1.81619439
109Morphological abnormality of the pyramidal tract (HP:0002062)1.78786624
110Rigidity (HP:0002063)1.78600914
111Alopecia of scalp (HP:0002293)1.77019633
112Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.75398179
113Degeneration of the lateral corticospinal tracts (HP:0002314)1.75398179
114Psychosis (HP:0000709)1.75135371
115Lower limb asymmetry (HP:0100559)1.74964090
116Hypotrichosis (HP:0001006)1.73674753
117CNS hypomyelination (HP:0003429)1.71786826
118Thickened helices (HP:0000391)1.71277127
119Termporal pattern (HP:0011008)1.70316283
120Insidious onset (HP:0003587)1.70316283
121Agitation (HP:0000713)1.70087466
122Ankyloglossia (HP:0010296)1.69315882
123Failure to thrive in infancy (HP:0001531)1.68383460
124Abnormality of salivation (HP:0100755)1.66805904
125Specific learning disability (HP:0001328)1.65862307
126Pheochromocytoma (HP:0002666)1.65751604
127Rapidly progressive (HP:0003678)1.65499285
128Spinal canal stenosis (HP:0003416)1.65048050
129Anosmia (HP:0000458)1.64067539

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.76812305
2NTRK34.71159225
3MAP3K93.87000200
4MARK12.88161892
5MAP3K42.75823188
6MINK12.75735548
7PRKD32.54845592
8DAPK22.45433795
9MAP2K72.37836278
10PAK62.37653198
11NTRK22.35283407
12KSR22.19175820
13MAP3K122.17592199
14TNIK2.08757445
15CAMKK11.96547856
16RIPK41.87534603
17MAP2K41.76233644
18NTRK11.72666655
19STK381.65941871
20KSR11.62401735
21RIPK11.58488738
22CDK51.56115518
23PRPF4B1.55606868
24CASK1.52632312
25MAP3K131.48381560
26ARAF1.45046019
27DAPK11.43595695
28FES1.40947700
29TYRO31.36817310
30LMTK21.32006296
31GRK51.30097897
32SIK21.29148398
33PLK21.25422604
34MAPK131.24422780
35PRKCG1.19464943
36CDK191.18656952
37MAP3K21.17604352
38PNCK1.13574052
39TNK21.07961142
40PHKG21.07952665
41PHKG11.07952665
42UHMK11.07702571
43TAOK11.04279484
44CAMK11.03656315
45FGFR21.03148810
46PKN10.98908813
47SGK2230.97361012
48SGK4940.97361012
49PRKCH0.95782822
50PINK10.95481678
51STK110.91044475
52CAMK2A0.90341940
53SGK20.86242903
54CAMKK20.85323013
55RAF10.85159605
56LATS20.84942583
57CDK180.84797289
58CDK150.84128267
59MAPK120.78564127
60CDK140.78453346
61ALK0.78083980
62CAMK2B0.77477707
63SGK30.74798289
64NEK60.74317465
65CDK11A0.73604185
66BMPR20.71243904
67SGK10.68248289
68MAP3K10.67667854
69PAK30.66559943
70RET0.65900822
71DYRK1A0.64005696
72ERBB20.63262153
73PDK10.62661592
74MARK20.60897015
75CDC42BPA0.59734845
76BRSK10.58547936
77PTK2B0.58358734
78PDPK10.57428072
79NME10.54215516
80CAMK2G0.52950918
81OXSR10.52324771
82CAMK1D0.49712479
83FER0.49489106
84RPS6KA30.48619302
85PRKCZ0.47867627
86MET0.47810776
87MAPK100.47746999
88MAP3K70.46511291
89ROCK10.45492227
90MAPKAPK50.45458776
91WNK10.45208954
92PIM20.44721174
93LIMK10.44656715
94CAMK40.43993024
95CAMK2D0.43967478
96MAP3K60.42876155
97NEK10.42374416
98ROCK20.40632047
99MAP2K60.40336680
100PRKCE0.39972059
101CSNK1G20.39824318
102FGR0.39763986
103CAMK1G0.39035228
104FYN0.38800786
105BRAF0.38721167
106DAPK30.35409948
107MAP2K10.34346421
108DMPK0.33551934
109MAPK80.33035491
110PTK20.32875134
111MUSK0.32238808
112BMX0.30879312
113RPS6KA20.29904575
114CSNK1D0.29842855
115PRKD20.29733295
116PRKCB0.29621906
117PRKCA0.29056439
118STK390.27663952
119RPS6KB10.27312774

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.69076212
2Synaptic vesicle cycle_Homo sapiens_hsa047213.32853415
3Olfactory transduction_Homo sapiens_hsa047402.92803164
4GABAergic synapse_Homo sapiens_hsa047272.73964621
5Circadian entrainment_Homo sapiens_hsa047132.68660451
6Long-term potentiation_Homo sapiens_hsa047202.66845599
7Glutamatergic synapse_Homo sapiens_hsa047242.61276708
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57534994
9Morphine addiction_Homo sapiens_hsa050322.47210408
10Amphetamine addiction_Homo sapiens_hsa050312.43445835
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26380951
12Salivary secretion_Homo sapiens_hsa049702.21372122
13Dopaminergic synapse_Homo sapiens_hsa047282.09048606
14Gastric acid secretion_Homo sapiens_hsa049712.07924870
15Insulin secretion_Homo sapiens_hsa049112.05853253
16Cholinergic synapse_Homo sapiens_hsa047251.92337591
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.86855157
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68400818
19Oxytocin signaling pathway_Homo sapiens_hsa049211.67272376
20Vitamin B6 metabolism_Homo sapiens_hsa007501.66918491
21Taste transduction_Homo sapiens_hsa047421.66545601
22Calcium signaling pathway_Homo sapiens_hsa040201.65281612
23Long-term depression_Homo sapiens_hsa047301.64182095
24Renin secretion_Homo sapiens_hsa049241.60301121
25Cocaine addiction_Homo sapiens_hsa050301.58873570
26GnRH signaling pathway_Homo sapiens_hsa049121.56748497
27Serotonergic synapse_Homo sapiens_hsa047261.54874276
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54772629
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43249473
30Nitrogen metabolism_Homo sapiens_hsa009101.37979433
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35568801
32cAMP signaling pathway_Homo sapiens_hsa040241.34628748
33Collecting duct acid secretion_Homo sapiens_hsa049661.33252314
34Gap junction_Homo sapiens_hsa045401.31532954
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29256836
36Glioma_Homo sapiens_hsa052141.21706278
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19794341
38Melanogenesis_Homo sapiens_hsa049161.15379906
39Estrogen signaling pathway_Homo sapiens_hsa049151.11653674
40ErbB signaling pathway_Homo sapiens_hsa040121.09294249
41Type II diabetes mellitus_Homo sapiens_hsa049301.06631483
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04195185
43Axon guidance_Homo sapiens_hsa043601.03795259
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02404960
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96682957
46Dorso-ventral axis formation_Homo sapiens_hsa043200.95574964
47Oocyte meiosis_Homo sapiens_hsa041140.94373578
48Cardiac muscle contraction_Homo sapiens_hsa042600.92912129
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.92347236
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.91631401
51Pancreatic secretion_Homo sapiens_hsa049720.89392214
52Vibrio cholerae infection_Homo sapiens_hsa051100.83063884
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79575815
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79543057
55Choline metabolism in cancer_Homo sapiens_hsa052310.78882094
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77552804
57Phototransduction_Homo sapiens_hsa047440.75978338
58Thyroid hormone synthesis_Homo sapiens_hsa049180.75292389
59MAPK signaling pathway_Homo sapiens_hsa040100.72812471
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71798134
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.69965657
62Dilated cardiomyopathy_Homo sapiens_hsa054140.68901446
63Histidine metabolism_Homo sapiens_hsa003400.68490202
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66342831
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65856218
66VEGF signaling pathway_Homo sapiens_hsa043700.65485801
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65346889
68Arginine and proline metabolism_Homo sapiens_hsa003300.64471573
69Hippo signaling pathway_Homo sapiens_hsa043900.62343960
70Ras signaling pathway_Homo sapiens_hsa040140.61723484
71Type I diabetes mellitus_Homo sapiens_hsa049400.61425034
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.60516315
73Rap1 signaling pathway_Homo sapiens_hsa040150.60010399
74Inositol phosphate metabolism_Homo sapiens_hsa005620.54216954
75Endocytosis_Homo sapiens_hsa041440.53318287
76beta-Alanine metabolism_Homo sapiens_hsa004100.53084883
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51859022
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51153898
79Alcoholism_Homo sapiens_hsa050340.50814310
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50608004
81Wnt signaling pathway_Homo sapiens_hsa043100.50577234
82Glucagon signaling pathway_Homo sapiens_hsa049220.50497073
83Non-small cell lung cancer_Homo sapiens_hsa052230.49659007
84Circadian rhythm_Homo sapiens_hsa047100.48472566
85mTOR signaling pathway_Homo sapiens_hsa041500.46829846
86Endometrial cancer_Homo sapiens_hsa052130.46057571
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45520373
88Arginine biosynthesis_Homo sapiens_hsa002200.45076682
89Bile secretion_Homo sapiens_hsa049760.44107579
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43126158
91Tight junction_Homo sapiens_hsa045300.42374425
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42363464
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42357436
94Ether lipid metabolism_Homo sapiens_hsa005650.41316667
95Prion diseases_Homo sapiens_hsa050200.37367272
96Chemokine signaling pathway_Homo sapiens_hsa040620.37194913
97Insulin signaling pathway_Homo sapiens_hsa049100.35994549
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35647903
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35605294
100Renal cell carcinoma_Homo sapiens_hsa052110.35365277
101Ovarian steroidogenesis_Homo sapiens_hsa049130.34817063
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34498029
103ECM-receptor interaction_Homo sapiens_hsa045120.34479837
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34287616
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33459866
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33233913
107Notch signaling pathway_Homo sapiens_hsa043300.33146886
108Hedgehog signaling pathway_Homo sapiens_hsa043400.32216653
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32155356
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.30677343
111AMPK signaling pathway_Homo sapiens_hsa041520.29817718
112African trypanosomiasis_Homo sapiens_hsa051430.29807539
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29090950
114Fatty acid biosynthesis_Homo sapiens_hsa000610.23663999

Most similar genes based on co-expression Upload to Enrichr

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