ARHGEF40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein similar to guanosine nucleotide exchange factors for Rho GTPases. The encoded protein contains in its C-terminus a GEF domain involved in exchange activity and a pleckstrin homology domain. Alternatively spliced transcripts that encode different proteins have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)9.41612483
2post-embryonic morphogenesis (GO:0009886)5.57261395
3detection of molecule of bacterial origin (GO:0032490)5.46321109
4lateral ventricle development (GO:0021670)5.19842829
5paraxial mesoderm development (GO:0048339)5.10025390
6negative regulation of macroautophagy (GO:0016242)4.91136803
7positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.70651244
8auditory receptor cell stereocilium organization (GO:0060088)4.45832216
9energy homeostasis (GO:0097009)3.85886029
10epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.75427591
11negative regulation of meiosis (GO:0045835)3.72139377
12inner ear receptor stereocilium organization (GO:0060122)3.71397004
13ganglion development (GO:0061548)3.56547877
14phosphate ion homeostasis (GO:0055062)3.55520989
15trivalent inorganic anion homeostasis (GO:0072506)3.55520989
16sulfate transmembrane transport (GO:1902358)3.55332529
17cellular anion homeostasis (GO:0030002)3.53760557
18cell proliferation involved in metanephros development (GO:0072203)3.50975992
19bone trabecula formation (GO:0060346)3.49606677
20regulation of apoptotic cell clearance (GO:2000425)3.44169346
21sulfate transport (GO:0008272)3.41403671
22mesonephros development (GO:0001823)3.30312646
23lateral sprouting from an epithelium (GO:0060601)3.27360021
24basement membrane organization (GO:0071711)3.24417325
25metanephric mesenchyme development (GO:0072075)3.22778527
26extracellular regulation of signal transduction (GO:1900115)3.22032263
27extracellular negative regulation of signal transduction (GO:1900116)3.22032263
28fat-soluble vitamin catabolic process (GO:0042363)3.21811640
29vitamin catabolic process (GO:0009111)3.21811640
30positive regulation of neurological system process (GO:0031646)3.20880294
31regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.17738313
32low-density lipoprotein particle clearance (GO:0034383)3.17393873
33regulation of mesoderm development (GO:2000380)3.16640642
34detection of external biotic stimulus (GO:0098581)3.12127059
35kidney mesenchyme development (GO:0072074)3.10680690
36chondrocyte proliferation (GO:0035988)3.09647950
37trophoblast giant cell differentiation (GO:0060707)3.09484187
38head development (GO:0060322)3.05117825
39negative regulation of embryonic development (GO:0045992)2.96100662
40phagocytosis, recognition (GO:0006910)2.96015542
41apoptotic cell clearance (GO:0043277)2.93235356
42endodermal cell differentiation (GO:0035987)2.92945857
43neuron projection extension involved in neuron projection guidance (GO:1902284)2.90315287
44axon extension involved in axon guidance (GO:0048846)2.90315287
45planar cell polarity pathway involved in neural tube closure (GO:0090179)2.89529291
46cell-cell junction maintenance (GO:0045217)2.89500246
47cell proliferation involved in kidney development (GO:0072111)2.89343187
48craniofacial suture morphogenesis (GO:0097094)2.85188846
49barbed-end actin filament capping (GO:0051016)2.85134474
50regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.81267614
51mesenchyme morphogenesis (GO:0072132)2.80382155
52detection of biotic stimulus (GO:0009595)2.75584910
53mesenchyme development (GO:0060485)2.74724482
54regulation of extracellular matrix disassembly (GO:0010715)2.74603390
55negative regulation of smooth muscle cell migration (GO:0014912)2.74472538
56negative regulation of fatty acid transport (GO:2000192)2.74049969
57somatic stem cell division (GO:0048103)2.72793212
58mannose metabolic process (GO:0006013)2.71235000
59wound healing, spreading of epidermal cells (GO:0035313)2.70799966
60stress fiber assembly (GO:0043149)2.69330791
61mesenchymal cell differentiation involved in renal system development (GO:2001012)2.69041519
62mesenchymal cell differentiation involved in kidney development (GO:0072161)2.69041519
63collagen fibril organization (GO:0030199)2.68261689
64dermatan sulfate metabolic process (GO:0030205)2.68047720
65positive regulation of extracellular matrix organization (GO:1903055)2.68007522
66regulation of interleukin-6 biosynthetic process (GO:0045408)2.67678437
67negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.66951040
68positive regulation by symbiont of host defense response (GO:0052509)2.66030213
69modulation by symbiont of host defense response (GO:0052031)2.66030213
70modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.66030213
71modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.66030213
72positive regulation by organism of defense response of other organism involved in symbiotic interact2.66030213
73modulation by symbiont of host immune response (GO:0052553)2.66030213
74glomerulus development (GO:0032835)2.65926705
75positive regulation of cholesterol efflux (GO:0010875)2.65347435
76complement activation, alternative pathway (GO:0006957)2.62741537
77notochord development (GO:0030903)2.61787214
78protein heterotrimerization (GO:0070208)2.61404753
79regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.60561244
80cranial suture morphogenesis (GO:0060363)2.60333504
81dermatan sulfate biosynthetic process (GO:0030208)2.59989835
82outer ear morphogenesis (GO:0042473)2.59847097
83DNA catabolic process, exonucleolytic (GO:0000738)2.59190334
84negative regulation of granulocyte differentiation (GO:0030853)2.58903122
85cell migration involved in heart development (GO:0060973)2.56424336
86cell surface receptor signaling pathway involved in heart development (GO:0061311)2.56293623
87G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.56276202
88face development (GO:0060324)2.54670026
89collagen metabolic process (GO:0032963)2.54414945
90embryonic skeletal joint morphogenesis (GO:0060272)2.53033603
91leukocyte migration involved in inflammatory response (GO:0002523)2.51839031
92negative regulation of fibrinolysis (GO:0051918)2.49180965
93bicarbonate transport (GO:0015701)2.48169504
94chondroitin sulfate biosynthetic process (GO:0030206)2.48162607
95neuron remodeling (GO:0016322)2.47703589
96sequestering of extracellular ligand from receptor (GO:0035581)2.47539079
97chondroitin sulfate catabolic process (GO:0030207)2.47526728
98cell proliferation in forebrain (GO:0021846)2.47438043
99embryonic camera-type eye development (GO:0031076)2.46671269
100negative regulation of cell fate specification (GO:0009996)2.45997522
101convergent extension (GO:0060026)2.45543609
102response to pheromone (GO:0019236)2.44614507
103DNA damage response, detection of DNA damage (GO:0042769)2.44256353
104lung-associated mesenchyme development (GO:0060484)2.44108080
105regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.44103252
106semaphorin-plexin signaling pathway (GO:0071526)2.44091863
107diaphragm development (GO:0060539)2.43710457
108mesenchymal cell proliferation (GO:0010463)2.43435175
109replicative senescence (GO:0090399)2.43123300
110positive regulation of vascular permeability (GO:0043117)2.42715477
111positive regulation of gastrulation (GO:2000543)2.42659594
112smooth muscle tissue development (GO:0048745)2.42470941
113bone remodeling (GO:0046849)2.42392043
114collagen catabolic process (GO:0030574)2.42332047
115cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.41763448
116negative regulation of response to extracellular stimulus (GO:0032105)2.41509027
117negative regulation of response to nutrient levels (GO:0032108)2.41509027
118triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.39523883
119specification of organ identity (GO:0010092)2.39342974
120middle ear morphogenesis (GO:0042474)2.39221825
121response to laminar fluid shear stress (GO:0034616)2.38537454
122negative regulation of catenin import into nucleus (GO:0035414)2.38237987
123positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.38174964
124pattern specification involved in kidney development (GO:0061004)2.37889837
125peptidyl-glutamic acid carboxylation (GO:0017187)2.37768174
126protein carboxylation (GO:0018214)2.37768174
127negative regulation of glial cell proliferation (GO:0060253)2.37749660
128negative regulation of stem cell proliferation (GO:2000647)2.37432899
129plasma lipoprotein particle clearance (GO:0034381)2.37257970
130tooth mineralization (GO:0034505)2.36595545
131positive regulation of hormone biosynthetic process (GO:0046886)2.35919395
132establishment of planar polarity (GO:0001736)2.35481104
133establishment of tissue polarity (GO:0007164)2.35481104
134regulation of macrophage cytokine production (GO:0010935)2.35445846
135cardiac epithelial to mesenchymal transition (GO:0060317)2.35320272
136Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.34655985
137positive regulation of uterine smooth muscle contraction (GO:0070474)2.33301129
138negative regulation of axon guidance (GO:1902668)2.32955541
139ribosome assembly (GO:0042255)2.32877290
140negative regulation of leukocyte chemotaxis (GO:0002689)2.32562572
141anatomical structure regression (GO:0060033)2.32151983
142multicellular organismal macromolecule metabolic process (GO:0044259)2.32080198
143embryonic forelimb morphogenesis (GO:0035115)2.32065432
144camera-type eye morphogenesis (GO:0048593)2.30801941
145regulation of non-canonical Wnt signaling pathway (GO:2000050)2.30759722
146signal transduction involved in regulation of gene expression (GO:0023019)2.30493089
147regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.30434568
148cellular extravasation (GO:0045123)2.29907878
149glial cell migration (GO:0008347)2.29819146
150negative regulation of erythrocyte differentiation (GO:0045647)2.28430783
151positive regulation of cellular amide metabolic process (GO:0034250)2.27673919
152cortical actin cytoskeleton organization (GO:0030866)2.27200678
153skin morphogenesis (GO:0043589)2.26968097
154substrate-dependent cell migration (GO:0006929)2.26907096
155regulation of extracellular matrix organization (GO:1903053)2.26487066
156regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.26202856
157insulin-like growth factor receptor signaling pathway (GO:0048009)2.25190637
158extracellular matrix disassembly (GO:0022617)2.24493660
159cochlea morphogenesis (GO:0090103)2.24053683
160diacylglycerol metabolic process (GO:0046339)2.22928345
161cellular response to epinephrine stimulus (GO:0071872)2.22778231
162extracellular fibril organization (GO:0043206)2.20457803
163non-canonical Wnt signaling pathway (GO:0035567)2.20409443
164negative regulation of cartilage development (GO:0061037)2.20308796
165alpha-linolenic acid metabolic process (GO:0036109)2.19884705
166regulation of plasminogen activation (GO:0010755)2.19524569
167regulation of establishment of planar polarity (GO:0090175)2.19473074
168cellular response to monoamine stimulus (GO:0071868)2.18652107
169cellular response to catecholamine stimulus (GO:0071870)2.18652107
170cell junction maintenance (GO:0034331)2.17646054
171positive regulation of cholesterol transport (GO:0032376)2.17515603
172positive regulation of sterol transport (GO:0032373)2.17515603
173multicellular organismal catabolic process (GO:0044243)2.15687859
174multicellular organismal metabolic process (GO:0044236)2.15657044
175fibril organization (GO:0097435)2.15483917
176cortical cytoskeleton organization (GO:0030865)2.14311867
177axon extension (GO:0048675)2.13437766
178cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.13412727
179positive regulation of phagocytosis (GO:0050766)2.13063053
180endothelial cell morphogenesis (GO:0001886)2.13038747
181venous blood vessel morphogenesis (GO:0048845)2.11724559
182positive regulation of receptor recycling (GO:0001921)2.10568154
183polyketide metabolic process (GO:0030638)14.8697301
184doxorubicin metabolic process (GO:0044598)14.8697301
185daunorubicin metabolic process (GO:0044597)14.8697301

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.45246657
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.42215355
3EED_16625203_ChIP-ChIP_MESCs_Mouse3.35330326
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.20082064
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.10604091
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.94539405
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.94254159
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.94254159
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.94254159
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.82326377
11POU5F1_16153702_ChIP-ChIP_HESCs_Human2.74420593
12PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.71451422
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.68096494
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54214704
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54214704
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.48321012
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.37771030
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.28031782
19RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.26772798
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24484664
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20731462
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.19371580
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17673508
24BMI1_23680149_ChIP-Seq_NPCS_Mouse2.08387963
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.06555081
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06468114
27LXR_22292898_ChIP-Seq_THP-1_Human2.01483909
28TP53_20018659_ChIP-ChIP_R1E_Mouse1.99200266
29KDM2B_26808549_Chip-Seq_K562_Human1.97464911
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.96124689
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.95207395
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91653655
33GBX2_23144817_ChIP-Seq_PC3_Human1.90786024
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.88953011
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.88762294
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.82546592
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.81904070
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81272777
39CLOCK_20551151_ChIP-Seq_293T_Human1.80411570
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.75532434
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75390682
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74374352
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73844029
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70356648
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69842020
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.67266405
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66674666
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66349885
49ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.65699711
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.63946639
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.62332323
52KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.61842788
53KDM2B_26808549_Chip-Seq_DND41_Human1.60537255
54NFIB_24661679_ChIP-Seq_LUNG_Mouse1.59414125
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.57387243
56SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.57048298
57NANOG_16153702_ChIP-ChIP_HESCs_Human1.55999888
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52907637
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51550854
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.49303443
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.47604187
62VDR_21846776_ChIP-Seq_THP-1_Human1.47448324
63CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.46712986
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46680564
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45569670
66EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42235348
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42055083
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41955105
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41808286
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40171394
71TCF3_18692474_ChIP-Seq_MEFs_Mouse1.40048180
72E2F7_22180533_ChIP-Seq_HELA_Human1.38019122
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.37093567
74SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36862680
75TCF7_22412390_ChIP-Seq_EML_Mouse1.36742967
76EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36346693
77CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35727098
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34760006
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33975696
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.33121824
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32456431
82TCF3_18692474_ChIP-Seq_MESCs_Mouse1.31032444
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30647970
84FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.30104392
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30047873
86VDR_22108803_ChIP-Seq_LS180_Human1.29620097
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.29493033
88E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29444369
89NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.28426687
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27943161
91RXR_22158963_ChIP-Seq_LIVER_Mouse1.26246348
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25879502
93DROSHA_22980978_ChIP-Seq_HELA_Human1.25423402
94MYC_19079543_ChIP-ChIP_MESCs_Mouse1.24355185
95SMC1_22415368_ChIP-Seq_MEFs_Mouse1.24124678
96* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23671463
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23499430
98OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22854320
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.22626862
100* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22335892
101NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21256794
102VDR_24763502_ChIP-Seq_THP-1_Human1.18816074
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16744758
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.16708095
105FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15118490
106LXR_22158963_ChIP-Seq_LIVER_Mouse1.15106722
107RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14486255
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14363045
109ISL1_27105846_Chip-Seq_CPCs_Mouse1.14360497
110RACK7_27058665_Chip-Seq_MCF-7_Human1.13390031
111P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12843188
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12437444
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11573003
114HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09580279
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09375754
116MYC_18555785_ChIP-Seq_MESCs_Mouse1.09288699
117RNF2_27304074_Chip-Seq_NSC_Mouse1.09192428
118SMC3_22415368_ChIP-Seq_MEFs_Mouse1.09123718
119BP1_19119308_ChIP-ChIP_Hs578T_Human1.08763460
120GATA1_26923725_Chip-Seq_HPCs_Mouse1.08232719
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06017770
122SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04709380
123TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04065163
124CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03820869
125STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03716166
126ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03380144
127TBX20_22080862_ChIP-Seq_HEART_Mouse1.03319079
128TBX20_22328084_ChIP-Seq_HEART_Mouse1.03319079
129SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03268570
130SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01978792
131TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00426239
132CTCF_27219007_Chip-Seq_Bcells_Human0.99358259
133NOTCH1_21737748_ChIP-Seq_TLL_Human0.98833896
134PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98744574
135TP53_23651856_ChIP-Seq_MEFs_Mouse0.98549801
136MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97960189
137ERG_21242973_ChIP-ChIP_JURKAT_Human0.97930965
138RXR_22108803_ChIP-Seq_LS180_Human0.97775884
139FOXA2_19822575_ChIP-Seq_HepG2_Human0.96898688
140SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96887806
141TP53_18474530_ChIP-ChIP_U2OS_Human0.96683513
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95598875
143SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94654414
144Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94617394
145ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94437100
146KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94384514
147ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93711303
148EP300_21415370_ChIP-Seq_HL-1_Mouse0.92345739
149PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91804058
150E2F1_18555785_Chip-Seq_ESCs_Mouse0.89857085
151FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89064421
152TP53_22127205_ChIP-Seq_IMR90_Human0.87736563
153TP53_16413492_ChIP-PET_HCT116_Human0.86975462
154EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85630212
155CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84885451
156EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84770404
157MYC_19829295_ChIP-Seq_ESCs_Human0.84453920
158POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84399268
159TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84399268
160MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.83357234
161FLI1_27457419_Chip-Seq_LIVER_Mouse0.81975362

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.50803130
2MP0003878_abnormal_ear_physiology5.50803130
3MP0003705_abnormal_hypodermis_morpholog4.11899428
4MP0008004_abnormal_stomach_pH3.89637675
5MP0003941_abnormal_skin_development3.71247888
6MP0000566_synostosis3.62959872
7MP0008438_abnormal_cutaneous_collagen3.22251297
8MP0005503_abnormal_tendon_morphology3.03194490
9MP0010030_abnormal_orbit_morphology2.67374822
10MP0000678_abnormal_parathyroid_gland2.56123633
11MP0006292_abnormal_olfactory_placode2.48988806
12MP0002938_white_spotting2.13631947
13MP0002249_abnormal_larynx_morphology2.04613852
14MP0003385_abnormal_body_wall2.00350566
15MP0009384_cardiac_valve_regurgitation1.98971450
16MP0000049_abnormal_middle_ear1.90898054
17MP0001485_abnormal_pinna_reflex1.87621130
18MP0005058_abnormal_lysosome_morphology1.85176422
19MP0005275_abnormal_skin_tensile1.83664015
20MP0000751_myopathy1.82397725
21MP0005171_absent_coat_pigmentation1.82099796
22MP0003937_abnormal_limbs/digits/tail_de1.77656337
23MP0003300_gastrointestinal_ulcer1.77350888
24MP0002277_abnormal_respiratory_mucosa1.76370741
25MP0001849_ear_inflammation1.74069895
26MP0005645_abnormal_hypothalamus_physiol1.72221461
27MP0009250_abnormal_appendicular_skeleto1.72212346
28MP0009278_abnormal_bone_marrow1.69550355
29MP0003879_abnormal_hair_cell1.69501384
30MP0005508_abnormal_skeleton_morphology1.68714492
31MP0003690_abnormal_glial_cell1.67382794
32MP0005423_abnormal_somatic_nervous1.67227184
33MP0003191_abnormal_cellular_cholesterol1.64148146
34MP0003172_abnormal_lysosome_physiology1.62363286
35MP0005257_abnormal_intraocular_pressure1.61784088
36MP0003828_pulmonary_edema1.60973140
37MP0005409_darkened_coat_color1.58907742
38MP0004130_abnormal_muscle_cell1.57959119
39MP0003091_abnormal_cell_migration1.56239098
40MP0003724_increased_susceptibility_to1.54922022
41MP0003279_aneurysm1.53228679
42MP0001346_abnormal_lacrimal_gland1.52005081
43MP0003122_maternal_imprinting1.47601571
44MP0005623_abnormal_meninges_morphology1.45161286
45MP0001533_abnormal_skeleton_physiology1.44767153
46MP0003942_abnormal_urinary_system1.44176202
47MP0004272_abnormal_basement_membrane1.43970541
48MP0003436_decreased_susceptibility_to1.43787301
49MP0002998_abnormal_bone_remodeling1.42452961
50MP0002932_abnormal_joint_morphology1.40895233
51MP0003755_abnormal_palate_morphology1.40570449
52MP0000762_abnormal_tongue_morphology1.36552264
53MP0010368_abnormal_lymphatic_system1.35664338
54MP0002896_abnormal_bone_mineralization1.35400195
55MP0004742_abnormal_vestibular_system1.35237383
56MP0003938_abnormal_ear_development1.33974004
57MP0001293_anophthalmia1.33607946
58MP0009053_abnormal_anal_canal1.33570635
59MP0002102_abnormal_ear_morphology1.31587121
60MP0004883_abnormal_blood_vessel1.31507105
61MP0009840_abnormal_foam_cell1.29585049
62MP0005595_abnormal_vascular_smooth1.29152707
63MP0000428_abnormal_craniofacial_morphol1.28853547
64MP0006054_spinal_hemorrhage1.28565699
65MP0001542_abnormal_bone_strength1.26961253
66MP0003329_amyloid_beta_deposits1.26595737
67MP0003935_abnormal_craniofacial_develop1.24761589
68MP0001986_abnormal_taste_sensitivity1.24376425
69MP0002971_abnormal_brown_adipose1.23878225
70MP0000733_abnormal_muscle_development1.21602342
71MP0000534_abnormal_ureter_morphology1.20972276
72MP0005023_abnormal_wound_healing1.19949967
73MP0009697_abnormal_copulation1.19154323
74MP0001915_intracranial_hemorrhage1.19001155
75MP0002233_abnormal_nose_morphology1.18558012
76MP0005164_abnormal_response_to1.18491090
77MP0002116_abnormal_craniofacial_bone1.16757147
78MP0005367_renal/urinary_system_phenotyp1.16486774
79MP0000516_abnormal_urinary_system1.16486774
80MP0006276_abnormal_autonomic_nervous1.15294558
81MP0004134_abnormal_chest_morphology1.14739221
82MP0004133_heterotaxia1.14587082
83MP0003115_abnormal_respiratory_system1.14480001
84MP0002933_joint_inflammation1.14433044
85MP0000432_abnormal_head_morphology1.12593156
86MP0005248_abnormal_Harderian_gland1.11987042
87MP0003936_abnormal_reproductive_system1.11510533
88MP0000604_amyloidosis1.11083742
89MP0000613_abnormal_salivary_gland1.10389799
90MP0005666_abnormal_adipose_tissue1.07775561
91MP0002111_abnormal_tail_morphology1.07551276
92MP0008007_abnormal_cellular_replicative1.07312668
93MP0003283_abnormal_digestive_organ1.05743842
94MP0005388_respiratory_system_phenotype1.05395229
95MP0002133_abnormal_respiratory_system1.05395229
96MP0003315_abnormal_perineum_morphology1.04895941
97MP0003111_abnormal_nucleus_morphology1.03234730
98MP0003566_abnormal_cell_adhesion1.02422432
99MP0001286_abnormal_eye_development1.00879751
100MP0005076_abnormal_cell_differentiation1.00325743
101MP0002160_abnormal_reproductive_system1.00278518
102MP0002089_abnormal_postnatal_growth/wei0.96200532
103MP0005375_adipose_tissue_phenotype0.95638300
104MP0002295_abnormal_pulmonary_circulatio0.94643130
105MP0005389_reproductive_system_phenotype0.94524320
106MP0003136_yellow_coat_color0.94294509
107MP0002419_abnormal_innate_immunity0.90943495
108MP0002109_abnormal_limb_morphology0.90582297
109MP0002751_abnormal_autonomic_nervous0.90430299
110MP0002060_abnormal_skin_morphology0.90106779
111MP0003303_peritoneal_inflammation0.89545199
112MP0000343_altered_response_to0.89298928
113MP0008260_abnormal_autophagy0.89163823
114MP0008932_abnormal_embryonic_tissue0.89078139
115MP0003119_abnormal_digestive_system0.87612367
116MP0010329_abnormal_lipoprotein_level0.87508430
117MP0002177_abnormal_outer_ear0.86440716
118MP0001614_abnormal_blood_vessel0.86378804
119MP0002114_abnormal_axial_skeleton0.86282764
120MP0000858_altered_metastatic_potential0.85371077
121MP0002113_abnormal_skeleton_development0.85356536
122MP0003075_altered_response_to0.84975990
123MP0002098_abnormal_vibrissa_morphology0.84626415
124MP0002254_reproductive_system_inflammat0.83912922
125MP0001175_abnormal_lung_morphology0.83826031
126MP0002092_abnormal_eye_morphology0.82888578
127MP0002163_abnormal_gland_morphology0.82193123
128MP0003077_abnormal_cell_cycle0.80591592
129MP0000681_abnormal_thyroid_gland0.80250279
130MP0000026_abnormal_inner_ear0.80176649
131MP0000163_abnormal_cartilage_morphology0.79865115
132MP0003634_abnormal_glial_cell0.79295857
133MP0000470_abnormal_stomach_morphology0.78644337
134MP0000627_abnormal_mammary_gland0.78067117
135MP0006138_congestive_heart_failure0.77794727
136MP0001958_emphysema0.77450011
137MP0000249_abnormal_blood_vessel0.75918954
138MP0002282_abnormal_trachea_morphology0.75493950
139MP0001299_abnormal_eye_distance/0.74424680
140MP0002697_abnormal_eye_size0.73418409
141MP0003693_abnormal_embryo_hatching0.73067617
142MP0000750_abnormal_muscle_regeneration0.72756916
143MP0003718_maternal_effect0.71782097
144MP0005360_urolithiasis0.70283420
145MP0000767_abnormal_smooth_muscle0.70155180
146MP0002128_abnormal_blood_circulation0.70142482
147MP0002108_abnormal_muscle_morphology0.70106093
148MP0001919_abnormal_reproductive_system0.69097725
149MP0002132_abnormal_respiratory_system0.68747842
150MP0002085_abnormal_embryonic_tissue0.68617620
151MP0005390_skeleton_phenotype0.68614800
152MP0002168_other_aberrant_phenotype0.67091353
153MP0000537_abnormal_urethra_morphology0.66694538
154MP0002115_abnormal_skeleton_extremities0.66133785
155MP0003890_abnormal_embryonic-extraembry0.65009422
156MP0005670_abnormal_white_adipose0.64109982
157MP0004858_abnormal_nervous_system0.62338380
158MP0001188_hyperpigmentation0.62180018
159MP0003045_fibrosis0.62149288
160MP0001270_distended_abdomen0.59822547

Predicted human phenotypes

RankGene SetZ-score
1Follicular hyperkeratosis (HP:0007502)6.55047811
2Parakeratosis (HP:0001036)6.48098533
3Alopecia of scalp (HP:0002293)6.05315397
4Unilateral renal agenesis (HP:0000122)6.00404912
5Bilateral sensorineural hearing impairment (HP:0008619)4.38864005
6Absent eyelashes (HP:0000561)4.37078059
7Absent eyebrow (HP:0002223)4.27749283
8Abnormality of dental color (HP:0011073)3.97246835
9Peritonitis (HP:0002586)3.91528481
10Recurrent corneal erosions (HP:0000495)3.79349503
11Cheilitis (HP:0100825)3.66611047
12Aortic aneurysm (HP:0004942)3.50718597
13Premature rupture of membranes (HP:0001788)3.49161952
14Vascular tortuosity (HP:0004948)3.33078956
15Cerebral aneurysm (HP:0004944)3.26534123
16Renal dysplasia (HP:0000110)3.20767010
17Arterial tortuosity (HP:0005116)3.15462782
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.11636555
19Absent/shortened dynein arms (HP:0200106)3.11636555
20Turricephaly (HP:0000262)2.84465375
21Protrusio acetabuli (HP:0003179)2.83797660
22Cervical subluxation (HP:0003308)2.83025736
23Increased variability in muscle fiber diameter (HP:0003557)2.80868624
24Mitral valve prolapse (HP:0001634)2.80162410
25Progressive external ophthalmoplegia (HP:0000590)2.79158848
26Complement deficiency (HP:0004431)2.77184128
27Genu recurvatum (HP:0002816)2.76776081
28Systemic lupus erythematosus (HP:0002725)2.72015768
29Blue sclerae (HP:0000592)2.71468682
30Biconcave vertebral bodies (HP:0004586)2.70475903
31Abnormality of complement system (HP:0005339)2.68954184
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.67747050
33Septo-optic dysplasia (HP:0100842)2.65023101
34Dilatation of the ascending aorta (HP:0005111)2.64631712
35Vertebral compression fractures (HP:0002953)2.63025899
36Deep venous thrombosis (HP:0002625)2.60685633
37Atrophic scars (HP:0001075)2.60297405
38Mitral regurgitation (HP:0001653)2.56491460
39Absent hair (HP:0002298)2.54554152
40Shallow orbits (HP:0000586)2.49250642
41Duplicated collecting system (HP:0000081)2.48972785
42Wide anterior fontanel (HP:0000260)2.46680250
43Obstructive sleep apnea (HP:0002870)2.45388348
44Abnormality of the renal collecting system (HP:0004742)2.40246266
45Mitral stenosis (HP:0001718)2.39867325
46Disproportionate tall stature (HP:0001519)2.38305224
47Amyloidosis (HP:0011034)2.34060065
48Chromsome breakage (HP:0040012)2.33562388
49Wormian bones (HP:0002645)2.32751125
50Ulnar bowing (HP:0003031)2.31481004
51Aneurysm (HP:0002617)2.31392205
52Vitreoretinal degeneration (HP:0000655)2.30677722
53Coronal craniosynostosis (HP:0004440)2.28846774
54Erythroderma (HP:0001019)2.26249457
55Abnormality of the parietal bone (HP:0002696)2.25822136
56Spondylolisthesis (HP:0003302)2.25716008
57Recurrent gram-negative bacterial infections (HP:0005420)2.25114344
58Spinal rigidity (HP:0003306)2.24413314
59Ectopic kidney (HP:0000086)2.22813446
60Abnormality of skeletal muscle fiber size (HP:0012084)2.22071474
61Hyperphosphatemia (HP:0002905)2.21729255
62Joint laxity (HP:0001388)2.20328605
63Convex nasal ridge (HP:0000444)2.20014250
64Ectopia lentis (HP:0001083)2.17168457
65Thin bony cortex (HP:0002753)2.15867559
66Hyperextensible skin (HP:0000974)2.14640334
67Blepharitis (HP:0000498)2.14382206
68Glomerulonephritis (HP:0000099)2.13894815
69Aortic dissection (HP:0002647)2.13058776
70Joint stiffness (HP:0001387)2.12093403
71Conical tooth (HP:0000698)2.11540383
72Neoplasm of the lung (HP:0100526)2.11165282
73Hemorrhage of the eye (HP:0011885)2.09311083
74Increased connective tissue (HP:0009025)2.08223643
75Bowel diverticulosis (HP:0005222)2.07932257
76Soft skin (HP:0000977)2.07807214
77Slender build (HP:0001533)2.05925924
78Arnold-Chiari malformation (HP:0002308)2.02080511
79Fragile skin (HP:0001030)2.01736809
80Aplasia cutis congenita (HP:0001057)2.01717848
81Camptodactyly of toe (HP:0001836)2.01643557
82Morphological abnormality of the middle ear (HP:0008609)1.99959807
83Hyperacusis (HP:0010780)1.98882784
84Ankle contracture (HP:0006466)1.98110033
85Patellar aplasia (HP:0006443)1.97910995
86Aplasia of the musculature (HP:0100854)1.97906805
87Renal agenesis (HP:0000104)1.96866300
88Hypoventilation (HP:0002791)1.96711604
89Abnormality of incisor morphology (HP:0011063)1.96285908
90Overgrowth (HP:0001548)1.95488051
91Bronchomalacia (HP:0002780)1.94692776
92Abolished electroretinogram (ERG) (HP:0000550)1.94230917
93Aplasia/Hypoplasia of the patella (HP:0006498)1.94079572
94Abnormality of dentin (HP:0010299)1.93924681
95Spinal cord lesions (HP:0100561)1.93159907
96Syringomyelia (HP:0003396)1.93159907
97Myocardial infarction (HP:0001658)1.92351212
98Absent radius (HP:0003974)1.91748796
99Bladder diverticulum (HP:0000015)1.91439846
100Ectropion (HP:0000656)1.91331794
101Absent forearm bone (HP:0003953)1.90629519
102Aplasia involving forearm bones (HP:0009822)1.90629519
103Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.90504046
104Short 4th metacarpal (HP:0010044)1.90504046
105Aplasia/Hypoplasia involving the musculature (HP:0001460)1.90116026
106Chronic otitis media (HP:0000389)1.90010595
107Neonatal short-limb short stature (HP:0008921)1.89427780
108Neoplasm of the respiratory system (HP:0100606)1.89372687
109Aortic regurgitation (HP:0001659)1.89351654
110Pulmonary artery stenosis (HP:0004415)1.88802907
111Xanthomatosis (HP:0000991)1.88311238
112Wrist flexion contracture (HP:0001239)1.86298147
113Abnormal respiratory epithelium morphology (HP:0012253)1.85897473
114Abnormal respiratory motile cilium morphology (HP:0005938)1.85897473
115Cutaneous finger syndactyly (HP:0010554)1.85557077
116Broad metatarsal (HP:0001783)1.84910526
117Ulnar claw (HP:0001178)1.84828111
118Skin nodule (HP:0200036)1.84622926
119Lymphangioma (HP:0100764)1.84013076
120Aortic valve stenosis (HP:0001650)1.82947531
121Thin ribs (HP:0000883)1.82200429
122Breast hypoplasia (HP:0003187)1.82151066
123Round ear (HP:0100830)1.81946437
124Supernumerary ribs (HP:0005815)1.81851090
125Neoplasm of the heart (HP:0100544)1.81642509
126Renal duplication (HP:0000075)1.80101604
127Broad long bones (HP:0005622)1.78751099
128Sparse eyelashes (HP:0000653)1.77969930
129Supernumerary bones of the axial skeleton (HP:0009144)1.77914760
130Mesomelia (HP:0003027)1.77905889
131Metaphyseal cupping (HP:0003021)1.75018023
132Joint hemorrhage (HP:0005261)1.74684217
133Abnormal ciliary motility (HP:0012262)1.74675247
134Neurofibrillary tangles (HP:0002185)1.74542666
135Abnormality of skull ossification (HP:0002703)1.73641967
136Flexion contracture of toe (HP:0005830)1.73157536
137Joint contractures involving the joints of the feet (HP:0100492)1.73157536
138Midline defect of the nose (HP:0004122)1.72497389
139Meckel diverticulum (HP:0002245)1.70786586
140Fibular aplasia (HP:0002990)1.70710855
141Dysostosis multiplex (HP:0000943)1.70633987
142Flared iliac wings (HP:0002869)1.70189526
143Tetany (HP:0001281)1.70165837
144Occipital encephalocele (HP:0002085)1.69598861
145Osteoarthritis (HP:0002758)1.69491394
146Partial duplication of the phalanx of hand (HP:0009999)1.69028271
147Asymmetric septal hypertrophy (HP:0001670)1.67939725
148Dislocated radial head (HP:0003083)1.67689937
149Broad face (HP:0000283)1.66692959
150Orchitis (HP:0100796)1.66689827
151Cutaneous syndactyly (HP:0012725)1.66370098
152Abnormality of the 4th metacarpal (HP:0010012)1.66212843
153Osteomalacia (HP:0002749)1.65997113
154Infantile muscular hypotonia (HP:0008947)1.65842401
155Abnormality of the peritoneum (HP:0002585)1.64993624
156Selective tooth agenesis (HP:0001592)1.64743229
157Gingivitis (HP:0000230)1.64547629
158Broad palm (HP:0001169)1.64057814
159Long toe (HP:0010511)1.63268018
160Bell-shaped thorax (HP:0001591)1.61227487
161Rectal prolapse (HP:0002035)1.60619663
162Triphalangeal thumb (HP:0001199)1.58526455
163Limited hip movement (HP:0008800)1.56957650
164Flat cornea (HP:0007720)1.54613278
165Myelomeningocele (HP:0002475)1.52208051
166Abnormality of the ileum (HP:0001549)1.51965228
167Abnormality of the incisor (HP:0000676)1.51393027
168Increased number of teeth (HP:0011069)1.51036121
169Reticulocytopenia (HP:0001896)1.50569569
170Fetal akinesia sequence (HP:0001989)1.49428432
171Synostosis of carpal bones (HP:0005048)1.49353812
172Type 1 muscle fiber predominance (HP:0003803)1.49171446
173Abnormality of the nasolacrimal system (HP:0000614)1.49112377
174Abnormality of calcium-phosphate metabolism (HP:0100530)1.49089722
175Hypoparathyroidism (HP:0000829)1.48183948
176Small epiphyses (HP:0010585)1.47199560
177Abnormality of the nasal septum (HP:0000419)1.47041339
178Corneal dystrophy (HP:0001131)1.46376781
179Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.46172446
180Vesicoureteral reflux (HP:0000076)1.46044018

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.52758546
2IRAK34.35740852
3SIK14.31805397
4EPHA24.30762762
5PLK43.82895843
6SIK23.68679349
7LATS13.45905015
8TRIB33.13439006
9ZAK3.08574080
10LATS23.04736420
11PAK42.95707465
12ERN12.95450759
13IRAK22.82991552
14STK38L2.81747838
15RIPK12.81367292
16MARK12.24768500
17SRPK12.21477213
18EPHB12.17452698
19IRAK12.16603355
20IRAK42.16217514
21BUB12.07466163
22FGFR42.06942849
23BLK1.82316616
24MAP2K31.80748373
25MARK31.73446726
26PRKD21.70099445
27NTRK11.67487509
28DDR21.63610491
29DYRK1B1.51833418
30EPHB21.47648450
31TLK11.46675741
32MAP3K71.46565909
33ICK1.42269847
34TYRO31.39825793
35MAP3K61.34573590
36TTK1.33275045
37PTK61.27815716
38CDK81.26014776
39TYK21.24960142
40CAMK1D1.23251376
41PDGFRB1.20025973
42MOS1.19292061
43CSK1.18839448
44RPS6KA21.16624423
45PKN21.13372329
46VRK11.08059500
47KIT1.04955809
48ZAP701.04584314
49MAP3K31.04468825
50DMPK1.03015909
51BRD41.02365199
52FGR0.98416283
53CAMK1G0.97600434
54SMG10.96426837
55RET0.94183688
56CDK70.94062962
57NEK90.93421893
58FES0.92973436
59MKNK10.92428768
60RPS6KC10.87567046
61RPS6KL10.87567046
62STK160.86692841
63MKNK20.86030287
64TTN0.85106344
65KSR20.84712920
66MARK20.83674824
67MAP2K40.82701191
68MTOR0.81558441
69EIF2AK20.80963591
70FGFR20.80764998
71ADRBK20.79313274
72CHEK20.79183840
73RIPK40.77409059
74FGFR30.77402881
75PAK60.75954008
76PDPK10.75295625
77RPS6KA60.74005880
78STK380.73511087
79STK30.72989902
80WEE10.72966551
81TNK20.72287285
82SGK30.72108153
83NTRK20.71903368
84MAPK120.69990186
85RPS6KA40.68863701
86SGK2230.68737804
87SGK4940.68737804
88PLK30.67304339
89BMPR1B0.66079111
90PRPF4B0.64957838
91EIF2AK10.64390201
92ATR0.63762361
93MAPK150.63567005
94CDC42BPA0.62752634
95PDGFRA0.62740754
96MAPK130.61850497
97JAK30.59517298
98HCK0.59407014
99ROCK20.59192140
100SGK20.58509727
101WNK10.56648154
102CSF1R0.56384034
103PLK10.55609361
104GSK3A0.54941682
105HIPK20.54642106
106CDK30.54573761
107PRKD30.54334592
108MAP3K10.53295332
109EPHA30.50818717
110PRKD10.50804420
111JAK20.50676799
112CDK60.49186770
113MAPK40.48495539
114MAP3K100.48273589
115TAOK10.47906984
116DYRK20.46777316
117LMTK20.46709713
118TSSK60.46151028
119FER0.45441503
120CASK0.44212180
121PNCK0.43356890
122TAOK20.43294025
123EEF2K0.43109539
124PKN10.43031239
125RPS6KB20.42598697
126ROCK10.41800549
127BMX0.41772577
128FYN0.41766586
129CHEK10.41319887
130IKBKB0.40744550
131STK40.39476445
132YES10.39238421
133RPS6KA50.37209140
134CSNK1A1L0.35716266
135CLK10.32255719
136CSNK1D0.31755999
137KDR0.31726291
138CAMK40.31199913
139AKT10.30901499
140TNIK0.30777429
141CHUK0.30586208
142ADRBK10.29685200
143MAP3K110.29550319
144CAMK10.27962315
145DYRK30.27937387
146TGFBR20.27590009
147PINK10.27216998
148AURKB0.26982032
149MAPK70.26407190
150FGFR10.26066060
151PLK20.25258744
152PRKCE0.25206642
153CSNK2A10.24595114
154TGFBR10.24506211
155PAK20.23540745
156NEK20.23310026
157ATM0.23188914
158PRKCI0.22733790
159INSRR0.22436339
160ABL20.20292046
161ERBB20.19924264
162PRKAA20.18302341
163PRKDC0.18100052
164GRK70.17605125
165AKT30.17353702
166CDC70.16653334
167PTK20.16218499
168MAP2K20.15528096
169MYLK0.15265781

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.60283020
2Spliceosome_Homo sapiens_hsa030402.50459194
3DNA replication_Homo sapiens_hsa030302.49528439
4Basal cell carcinoma_Homo sapiens_hsa052172.44486273
5RNA polymerase_Homo sapiens_hsa030202.42673995
6Ribosome_Homo sapiens_hsa030102.40545161
7Complement and coagulation cascades_Homo sapiens_hsa046102.32096822
8ECM-receptor interaction_Homo sapiens_hsa045122.29752255
9Other glycan degradation_Homo sapiens_hsa005112.28136937
10Hedgehog signaling pathway_Homo sapiens_hsa043402.17513104
11Homologous recombination_Homo sapiens_hsa034402.07861913
12Staphylococcus aureus infection_Homo sapiens_hsa051502.04660757
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.04598481
14Axon guidance_Homo sapiens_hsa043601.85568949
15Notch signaling pathway_Homo sapiens_hsa043301.81861985
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.81567106
17Hippo signaling pathway_Homo sapiens_hsa043901.80879606
18p53 signaling pathway_Homo sapiens_hsa041151.79220163
19Melanoma_Homo sapiens_hsa052181.77967107
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.76948074
21Cell cycle_Homo sapiens_hsa041101.72702972
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.72607133
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.63904929
24MicroRNAs in cancer_Homo sapiens_hsa052061.59338557
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59139773
26Osteoclast differentiation_Homo sapiens_hsa043801.56460437
27PPAR signaling pathway_Homo sapiens_hsa033201.56092537
28Mismatch repair_Homo sapiens_hsa034301.54142645
29Wnt signaling pathway_Homo sapiens_hsa043101.52915252
30Small cell lung cancer_Homo sapiens_hsa052221.44127965
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.41855599
32Pyrimidine metabolism_Homo sapiens_hsa002401.41454217
33Proteasome_Homo sapiens_hsa030501.41021749
34Adherens junction_Homo sapiens_hsa045201.38651125
35Basal transcription factors_Homo sapiens_hsa030221.35423690
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.33978414
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.33778316
38HTLV-I infection_Homo sapiens_hsa051661.31699745
39One carbon pool by folate_Homo sapiens_hsa006701.28774815
40Prion diseases_Homo sapiens_hsa050201.28298956
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.26774008
42TGF-beta signaling pathway_Homo sapiens_hsa043501.26194427
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20627892
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18576139
45Focal adhesion_Homo sapiens_hsa045101.17550639
46RNA transport_Homo sapiens_hsa030131.17496967
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16444117
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16057054
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15864636
50Pathways in cancer_Homo sapiens_hsa052001.13267647
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.11782657
52Dilated cardiomyopathy_Homo sapiens_hsa054141.11311509
53Mineral absorption_Homo sapiens_hsa049781.10752720
54Protein digestion and absorption_Homo sapiens_hsa049741.08461021
55Pertussis_Homo sapiens_hsa051331.08270833
56PI3K-Akt signaling pathway_Homo sapiens_hsa041511.08178356
57Nucleotide excision repair_Homo sapiens_hsa034201.06454566
58Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05031954
59Leishmaniasis_Homo sapiens_hsa051401.03644825
60Base excision repair_Homo sapiens_hsa034101.03247203
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00479903
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.98584208
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97495339
64Acute myeloid leukemia_Homo sapiens_hsa052210.97307650
65Epstein-Barr virus infection_Homo sapiens_hsa051690.97184867
66GnRH signaling pathway_Homo sapiens_hsa049120.96942806
67Lysosome_Homo sapiens_hsa041420.94183333
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93643750
69Graft-versus-host disease_Homo sapiens_hsa053320.93303499
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.92532024
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.92384752
72Estrogen signaling pathway_Homo sapiens_hsa049150.91027462
73RNA degradation_Homo sapiens_hsa030180.90388775
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87043857
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87037919
76Phagosome_Homo sapiens_hsa041450.86373544
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86114120
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85167738
79Bile secretion_Homo sapiens_hsa049760.84117344
80Gap junction_Homo sapiens_hsa045400.82310789
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81536843
82Platelet activation_Homo sapiens_hsa046110.81162634
83Endometrial cancer_Homo sapiens_hsa052130.80759784
84Dorso-ventral axis formation_Homo sapiens_hsa043200.78539429
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78051213
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77857912
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77598457
88Purine metabolism_Homo sapiens_hsa002300.77534586
89Renal cell carcinoma_Homo sapiens_hsa052110.76894816
90Ras signaling pathway_Homo sapiens_hsa040140.76636972
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76437466
92Proteoglycans in cancer_Homo sapiens_hsa052050.76217191
93Chemokine signaling pathway_Homo sapiens_hsa040620.73775669
94Lysine degradation_Homo sapiens_hsa003100.73479400
95VEGF signaling pathway_Homo sapiens_hsa043700.73362708
96Choline metabolism in cancer_Homo sapiens_hsa052310.73287776
97Non-small cell lung cancer_Homo sapiens_hsa052230.72820797
98Prolactin signaling pathway_Homo sapiens_hsa049170.72667725
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72431820
100Tuberculosis_Homo sapiens_hsa051520.72277932
101Bladder cancer_Homo sapiens_hsa052190.72153280
102Insulin signaling pathway_Homo sapiens_hsa049100.71345208
103Colorectal cancer_Homo sapiens_hsa052100.71286679
104Glycerolipid metabolism_Homo sapiens_hsa005610.70675115
105Rap1 signaling pathway_Homo sapiens_hsa040150.69882104
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69852817
107Ovarian steroidogenesis_Homo sapiens_hsa049130.69472745
108Nicotine addiction_Homo sapiens_hsa050330.69349498
109Pancreatic cancer_Homo sapiens_hsa052120.68959022
110AMPK signaling pathway_Homo sapiens_hsa041520.68727836
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68430698
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66595732
113Tight junction_Homo sapiens_hsa045300.66524471
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.66332858
115Measles_Homo sapiens_hsa051620.65850259
116MAPK signaling pathway_Homo sapiens_hsa040100.65561919
117Glioma_Homo sapiens_hsa052140.64867797
118Histidine metabolism_Homo sapiens_hsa003400.63421777
119Arachidonic acid metabolism_Homo sapiens_hsa005900.63247092
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62937218
121Prostate cancer_Homo sapiens_hsa052150.62784100
122Thyroid hormone synthesis_Homo sapiens_hsa049180.61653166
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.61025253
124Insulin resistance_Homo sapiens_hsa049310.60591198
125Autoimmune thyroid disease_Homo sapiens_hsa053200.59686551
126FoxO signaling pathway_Homo sapiens_hsa040680.59684323
127Amoebiasis_Homo sapiens_hsa051460.59623396
128Salmonella infection_Homo sapiens_hsa051320.58142690
129TNF signaling pathway_Homo sapiens_hsa046680.57679074
130Endocytosis_Homo sapiens_hsa041440.57216748
131Fatty acid degradation_Homo sapiens_hsa000710.56191614
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56136502
133Galactose metabolism_Homo sapiens_hsa000520.55651611
134Renin secretion_Homo sapiens_hsa049240.55385820
135Hematopoietic cell lineage_Homo sapiens_hsa046400.53669033
136Viral myocarditis_Homo sapiens_hsa054160.52934956
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51507468
138Taste transduction_Homo sapiens_hsa047420.50334969
139Sphingolipid metabolism_Homo sapiens_hsa006000.49692418
140Non-homologous end-joining_Homo sapiens_hsa034500.49366051
141Herpes simplex infection_Homo sapiens_hsa051680.49014414
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48989862
143Melanogenesis_Homo sapiens_hsa049160.48887016
144Systemic lupus erythematosus_Homo sapiens_hsa053220.48005304
145cAMP signaling pathway_Homo sapiens_hsa040240.47615825
146Calcium signaling pathway_Homo sapiens_hsa040200.47303183
147Malaria_Homo sapiens_hsa051440.47221845
148Huntingtons disease_Homo sapiens_hsa050160.44355758
149Apoptosis_Homo sapiens_hsa042100.43543930
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.43254313
151Toxoplasmosis_Homo sapiens_hsa051450.43196022
152Intestinal immune network for IgA production_Homo sapiens_hsa046720.41772679
153Viral carcinogenesis_Homo sapiens_hsa052030.40192896
154Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39970245
155Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39565386
156HIF-1 signaling pathway_Homo sapiens_hsa040660.39524225
157Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39162488
158ErbB signaling pathway_Homo sapiens_hsa040120.39096200
159Chronic myeloid leukemia_Homo sapiens_hsa052200.38775301
160Shigellosis_Homo sapiens_hsa051310.38132898

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