ARHGEF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.29910133
2desmosome organization (GO:0002934)6.16142409
3bundle of His cell to Purkinje myocyte communication (GO:0086069)5.60778506
4regulation of water loss via skin (GO:0033561)4.08859999
5establishment of skin barrier (GO:0061436)4.00441852
6intestinal cholesterol absorption (GO:0030299)3.63563712
7hormone catabolic process (GO:0042447)3.60849511
8COPI coating of Golgi vesicle (GO:0048205)3.55012495
9Golgi transport vesicle coating (GO:0048200)3.55012495
10positive regulation of epidermal cell differentiation (GO:0045606)3.54272324
11urea cycle (GO:0000050)3.48926177
12branching involved in mammary gland duct morphogenesis (GO:0060444)3.48247836
13intestinal absorption (GO:0050892)3.41904228
14surfactant homeostasis (GO:0043129)3.38427238
15urea metabolic process (GO:0019627)3.36799909
16mesodermal cell differentiation (GO:0048333)3.35902621
17cytoskeletal anchoring at plasma membrane (GO:0007016)3.34876696
18positive regulation of keratinocyte differentiation (GO:0045618)3.22731192
19cell-substrate junction assembly (GO:0007044)3.18899432
20peptide catabolic process (GO:0043171)3.18331611
21regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.18314571
22lung vasculature development (GO:0060426)3.16973659
23trophectodermal cell differentiation (GO:0001829)3.14586854
24epithelial cell-cell adhesion (GO:0090136)3.13615793
25positive regulation of Cdc42 GTPase activity (GO:0043089)3.13591067
26negative regulation of keratinocyte proliferation (GO:0010839)3.12347901
27activation of Rac GTPase activity (GO:0032863)3.11095664
28regulation of keratinocyte differentiation (GO:0045616)3.11055005
29regulation of endothelial cell chemotaxis (GO:2001026)3.10439361
30epidermal cell differentiation (GO:0009913)3.09600724
31regulation of keratinocyte proliferation (GO:0010837)3.08727327
32multicellular organismal water homeostasis (GO:0050891)3.08308810
33atrioventricular valve morphogenesis (GO:0003181)3.06936141
34endothelial cell chemotaxis (GO:0035767)3.06029711
35regulation of cholesterol homeostasis (GO:2000188)3.02403679
36cell adhesion mediated by integrin (GO:0033627)3.00624952
37regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.99800493
38planar cell polarity pathway involved in neural tube closure (GO:0090179)2.98775132
39hypotonic response (GO:0006971)2.95009370
40skin morphogenesis (GO:0043589)2.91803883
41epithelial cell differentiation involved in prostate gland development (GO:0060742)2.88339416
42intestinal epithelial cell development (GO:0060576)2.87570202
43adherens junction assembly (GO:0034333)2.86141387
44O-glycan processing (GO:0016266)2.82954920
45nitrogen cycle metabolic process (GO:0071941)2.82586131
46transcytosis (GO:0045056)2.81962857
47sulfur amino acid catabolic process (GO:0000098)2.81250765
48regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.81136928
49maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.81093145
50cell-cell junction assembly (GO:0007043)2.79430212
51cell-substrate adherens junction assembly (GO:0007045)2.77474639
52focal adhesion assembly (GO:0048041)2.77474639
53renal absorption (GO:0070293)2.73803979
54epidermis development (GO:0008544)2.73566646
55positive regulation of epidermis development (GO:0045684)2.73250312
56homocysteine metabolic process (GO:0050667)2.72738269
57water homeostasis (GO:0030104)2.70825564
58gastrulation with mouth forming second (GO:0001702)2.70767777
59regulation of transforming growth factor beta2 production (GO:0032909)2.70464634
60chemical homeostasis within a tissue (GO:0048875)2.69766380
61negative regulation of cell fate specification (GO:0009996)2.67471258
62receptor catabolic process (GO:0032801)2.66603501
63tight junction assembly (GO:0070830)2.66076266
64keratinocyte proliferation (GO:0043616)2.65444602
65basement membrane organization (GO:0071711)2.64237437
66keratinocyte differentiation (GO:0030216)2.63900869
67xenobiotic catabolic process (GO:0042178)2.63230462
68protein retention in ER lumen (GO:0006621)2.63146863
69response to nitrosative stress (GO:0051409)2.62811346
70vascular endothelial growth factor signaling pathway (GO:0038084)2.62501224
71embryonic process involved in female pregnancy (GO:0060136)2.61212465
72regulation of cardioblast differentiation (GO:0051890)2.60287366
73drug transmembrane transport (GO:0006855)2.59984458
74establishment of apical/basal cell polarity (GO:0035089)2.59021291
75nucleotide-sugar biosynthetic process (GO:0009226)2.58255200
76polarized epithelial cell differentiation (GO:0030859)2.58243106
77regulation of apoptotic process involved in morphogenesis (GO:1902337)2.56943044
78regulation of glucose import in response to insulin stimulus (GO:2001273)2.56427427
79growth hormone receptor signaling pathway (GO:0060396)2.54396849
80cellular response to epidermal growth factor stimulus (GO:0071364)2.54058126
81keratinization (GO:0031424)2.54000266
82negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.53416898
83phospholipid efflux (GO:0033700)2.53000929
84interferon-gamma secretion (GO:0072643)2.52378859
85wound healing, spreading of epidermal cells (GO:0035313)2.52243222
86negative regulation of fatty acid transport (GO:2000192)2.51416675
87cellular glucuronidation (GO:0052695)2.50564897
88hippo signaling (GO:0035329)2.50189293
89renal filtration (GO:0097205)2.49554224
90UDP-N-acetylglucosamine metabolic process (GO:0006047)2.49126112
91regulation of viral release from host cell (GO:1902186)2.47085420
92cellular response to vitamin D (GO:0071305)2.46931066
93retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.45696776
94cysteine metabolic process (GO:0006534)2.45001620
95positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.44738789
96dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.44363424
97lipoprotein metabolic process (GO:0042157)2.44325065
98regulation of transforming growth factor beta production (GO:0071634)2.42256037
99regulation of hippo signaling (GO:0035330)2.41293134
100maintenance of gastrointestinal epithelium (GO:0030277)2.40745842
101regulation of triglyceride catabolic process (GO:0010896)2.39880305
102semaphorin-plexin signaling pathway (GO:0071526)2.39701025
103ectoderm development (GO:0007398)2.38605559
104positive regulation of endothelial cell apoptotic process (GO:2000353)2.38571267
105regulation of epidermal cell differentiation (GO:0045604)2.37722135
106regulation of fatty acid beta-oxidation (GO:0031998)2.36801743
107drug catabolic process (GO:0042737)2.36789632
108COPII vesicle coating (GO:0048208)2.36704220
109regulation of bile acid biosynthetic process (GO:0070857)2.36337302
110apoptotic process involved in morphogenesis (GO:0060561)2.35995884
111calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.35000859
112morphogenesis of embryonic epithelium (GO:0016331)2.34382611
113cell junction assembly (GO:0034329)2.34360959
114positive regulation of p38MAPK cascade (GO:1900745)2.34121836
1154-hydroxyproline metabolic process (GO:0019471)2.33418837
116negative regulation of viral release from host cell (GO:1902187)2.33263114
117regulation of epidermis development (GO:0045682)2.32504685
118endocardial cushion development (GO:0003197)2.32426114
119ventricular cardiac muscle cell action potential (GO:0086005)2.31638451
120protein autoprocessing (GO:0016540)2.31326778
121keratinocyte development (GO:0003334)2.30845530
122regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.30586055
123phospholipid scrambling (GO:0017121)2.30001083
124gap junction assembly (GO:0016264)2.29964730
125sphingomyelin metabolic process (GO:0006684)2.29537882
126renal system development (GO:0072001)2.29266596
127hepatocyte apoptotic process (GO:0097284)2.28649236
128cell migration involved in sprouting angiogenesis (GO:0002042)2.28451527
129endodermal cell differentiation (GO:0035987)2.28220783
130peptide cross-linking (GO:0018149)2.27204135
131high-density lipoprotein particle remodeling (GO:0034375)2.26790276
132NADH metabolic process (GO:0006734)2.25915164
133blood vessel endothelial cell migration (GO:0043534)2.25624533
134urate metabolic process (GO:0046415)2.25059770
135gland morphogenesis (GO:0022612)2.25011412
136proline biosynthetic process (GO:0006561)2.24909360
137endothelial cell morphogenesis (GO:0001886)2.24839407
138cell junction organization (GO:0034330)2.24763460
139uronic acid metabolic process (GO:0006063)2.24322131
140glucuronate metabolic process (GO:0019585)2.24322131
141reverse cholesterol transport (GO:0043691)2.23696006
142branching involved in salivary gland morphogenesis (GO:0060445)2.23010748
143regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.22545524
144regulation of interleukin-8 secretion (GO:2000482)2.22406932
145cellular response to vitamin (GO:0071295)2.22135693
146regulation of transforming growth factor beta1 production (GO:0032908)2.21919422
147lymphangiogenesis (GO:0001946)2.21353724
148amino-acid betaine metabolic process (GO:0006577)2.21124084
149regulation of cell fate specification (GO:0042659)2.20895512
150flavonoid metabolic process (GO:0009812)2.20304612
151cellular response to growth hormone stimulus (GO:0071378)2.20151435
152drug transport (GO:0015893)2.20023001
153fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.19061391
154chondrocyte proliferation (GO:0035988)2.18485284
155fibrinolysis (GO:0042730)2.18165201
156lung alveolus development (GO:0048286)2.17861889
157lysine metabolic process (GO:0006553)2.17859607
158lysine catabolic process (GO:0006554)2.17859607
159lung epithelium development (GO:0060428)2.17605721
160epoxygenase P450 pathway (GO:0019373)2.17072767
161wound healing, spreading of cells (GO:0044319)2.16716700
162regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.16531490

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.45959346
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.27381738
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.79213970
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.16332531
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.99417297
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.94708871
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.82773740
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.82043493
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.80564969
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.67677787
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.54166532
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.41029795
13CLOCK_20551151_ChIP-Seq_293T_Human2.26161744
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.21458725
15SOX2_27498859_Chip-Seq_STOMACH_Mouse2.20300113
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.07278587
17ZNF217_24962896_ChIP-Seq_MCF-7_Human2.06005075
18* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.05075161
19* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.05075161
20* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.02875468
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.01845220
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.99364623
23SOX2_20726797_ChIP-Seq_SW620_Human1.97274894
24GATA4_25053715_ChIP-Seq_YYC3_Human1.96855662
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.94535407
26* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.88789470
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81320802
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.81260217
29FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.81162007
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.78939765
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.68739455
32GATA6_25053715_ChIP-Seq_YYC3_Human1.67434735
33CJUN_26792858_Chip-Seq_BT549_Human1.66937881
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66680675
35LXR_22292898_ChIP-Seq_THP-1_Human1.61734821
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59570463
37SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.57041516
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56346392
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.54362070
40SALL4_18804426_ChIP-ChIP_XEN_Mouse1.52345053
41FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.47208676
42P63_26484246_Chip-Seq_KERATINOCYTES_Human1.46576597
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46310567
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41325456
45TCF4_18268006_ChIP-ChIP_LS174T_Human1.41165723
46ZNF263_19887448_ChIP-Seq_K562_Human1.39095290
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38929718
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36075908
49TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35098502
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33070925
51TCF7_22412390_ChIP-Seq_EML_Mouse1.32929601
52KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32773405
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.32626103
54RUNX1_27514584_Chip-Seq_MCF-7_Human1.32564220
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31403662
56ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29652565
57RACK7_27058665_Chip-Seq_MCF-7_Human1.29271029
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28736243
59KLF5_25053715_ChIP-Seq_YYC3_Human1.28696699
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28482160
61EP300_21415370_ChIP-Seq_HL-1_Mouse1.28473740
62CHD1_26751641_Chip-Seq_LNCaP_Human1.26943171
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26795191
64FOXA2_19822575_ChIP-Seq_HepG2_Human1.26520443
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25760481
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24821183
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23444919
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22358740
69GATA3_24758297_ChIP-Seq_MCF-7_Human1.22194323
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22061836
71GATA1_22025678_ChIP-Seq_K562_Human1.21879285
72ATF3_27146783_Chip-Seq_COLON_Human1.21832811
73CREB1_26743006_Chip-Seq_LNCaP_Human1.21395787
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19901976
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19901976
76AHR_22903824_ChIP-Seq_MCF-7_Human1.17571943
77KDM2B_26808549_Chip-Seq_K562_Human1.16898590
78TP63_23658742_ChIP-Seq_EP156T_Human1.16145724
79AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15865823
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14846596
81TBX20_22328084_ChIP-Seq_HEART_Mouse1.12634932
82TBX20_22080862_ChIP-Seq_HEART_Mouse1.12634932
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.12351083
84* TP63_22573176_ChIP-Seq_HFKS_Human1.11817049
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11502399
86ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10375940
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09221674
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08005643
89EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06447730
90TP53_18474530_ChIP-ChIP_U2OS_Human1.05933996
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05551336
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04975417
93JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04856155
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04087847
95STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03481145
96THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03391368
97FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03314524
98* UBF1/2_26484160_Chip-Seq_HMECs_Human1.03292312
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01449337
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01079387
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00556022
102SMC4_20622854_ChIP-Seq_HELA_Human1.00060925
103FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96316635
104ERG_21242973_ChIP-ChIP_JURKAT_Human0.95814006
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95740668
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95235576
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94931510
108FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94668207
109ARNT_22903824_ChIP-Seq_MCF-7_Human0.94656124
110TP53_16413492_ChIP-PET_HCT116_Human0.93325277
111ELK3_25401928_ChIP-Seq_HUVEC_Human0.92578632
112MYC_22102868_ChIP-Seq_BL_Human0.92460545
113RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92038183
114CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91371023
115CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90551010
116ISL1_27105846_Chip-Seq_CPCs_Mouse0.90510307
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88836238
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88046474
119Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87733141
120RXR_22108803_ChIP-Seq_LS180_Human0.85790145
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85516831
122BRD4_25478319_ChIP-Seq_HGPS_Human0.85112062
123ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84927254
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83798678
125EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83058849
126KDM2B_26808549_Chip-Seq_DND41_Human0.82733452
127GATA2_19941826_ChIP-Seq_K562_Human0.82558422
128P300_27058665_Chip-Seq_ZR-75-30cells_Human0.79070924
129HNF4A_19822575_ChIP-Seq_HepG2_Human0.76907653
130FOXA1_25552417_ChIP-Seq_VCAP_Human0.76341611
131AR_21909140_ChIP-Seq_LNCAP_Human0.76124220

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.49070806
2MP0002796_impaired_skin_barrier3.36102656
3MP0005360_urolithiasis3.30351500
4MP0005275_abnormal_skin_tensile2.82241828
5MP0003705_abnormal_hypodermis_morpholog2.55871738
6MP0002139_abnormal_hepatobiliary_system2.48579027
7MP0002254_reproductive_system_inflammat2.48223858
8MP0005085_abnormal_gallbladder_physiolo2.47673894
9MP0004264_abnormal_extraembryonic_tissu2.46999194
10MP0001666_abnormal_nutrient_absorption2.29157425
11MP0003252_abnormal_bile_duct2.27197528
12MP0003941_abnormal_skin_development2.26689861
13MP0002060_abnormal_skin_morphology2.22556398
14MP0005365_abnormal_bile_salt2.19471502
15MP0005501_abnormal_skin_physiology2.12710123
16MP0010678_abnormal_skin_adnexa2.07354654
17MP0005409_darkened_coat_color2.01004651
18MP0000537_abnormal_urethra_morphology2.00409782
19MP0002098_abnormal_vibrissa_morphology1.99749468
20MP0008875_abnormal_xenobiotic_pharmacok1.98164470
21MP0003566_abnormal_cell_adhesion1.97488614
22MP0004272_abnormal_basement_membrane1.94236751
23MP0004019_abnormal_vitamin_homeostasis1.91703080
24MP0005076_abnormal_cell_differentiation1.84704481
25MP0003453_abnormal_keratinocyte_physiol1.75008614
26MP0003300_gastrointestinal_ulcer1.74864494
27MP0000383_abnormal_hair_follicle1.71630577
28MP0001216_abnormal_epidermal_layer1.71613241
29MP0010352_gastrointestinal_tract_polyps1.70932751
30MP0006054_spinal_hemorrhage1.63232295
31MP0000579_abnormal_nail_morphology1.62648337
32MP0010368_abnormal_lymphatic_system1.53399395
33MP0009053_abnormal_anal_canal1.52745565
34MP0009384_cardiac_valve_regurgitation1.48672310
35MP0000566_synostosis1.45237808
36MP0000762_abnormal_tongue_morphology1.45177100
37MP0004185_abnormal_adipocyte_glucose1.43561529
38MP0005257_abnormal_intraocular_pressure1.39685308
39MP0002877_abnormal_melanocyte_morpholog1.39129911
40MP0002138_abnormal_hepatobiliary_system1.38594176
41MP0009840_abnormal_foam_cell1.37153275
42MP0010771_integument_phenotype1.33752547
43MP0004947_skin_inflammation1.33588168
44MP0005083_abnormal_biliary_tract1.32896462
45MP0010329_abnormal_lipoprotein_level1.32012856
46MP0005023_abnormal_wound_healing1.31203347
47MP0000467_abnormal_esophagus_morphology1.26854779
48MP0000377_abnormal_hair_follicle1.23359640
49MP0009780_abnormal_chondrocyte_physiolo1.22407115
50MP0005248_abnormal_Harderian_gland1.22149313
51MP0004858_abnormal_nervous_system1.20938502
52MP0009643_abnormal_urine_homeostasis1.19916349
53MP0000462_abnormal_digestive_system1.17861186
54MP0004782_abnormal_surfactant_physiolog1.17821094
55MP0008004_abnormal_stomach_pH1.15937938
56MP0004381_abnormal_hair_follicle1.14867494
57MP0001346_abnormal_lacrimal_gland1.14833470
58MP0005084_abnormal_gallbladder_morpholo1.14490563
59MP0005367_renal/urinary_system_phenotyp1.13790267
60MP0000516_abnormal_urinary_system1.13790267
61MP0000538_abnormal_urinary_bladder1.13635185
62MP0010030_abnormal_orbit_morphology1.13614032
63MP0001765_abnormal_ion_homeostasis1.08335749
64MP0002896_abnormal_bone_mineralization1.06845126
65MP0002166_altered_tumor_susceptibility1.05207473
66MP0000427_abnormal_hair_cycle1.04260068
67MP0002234_abnormal_pharynx_morphology1.04065732
68MP0003191_abnormal_cellular_cholesterol1.03515367
69MP0001191_abnormal_skin_condition1.01592944
70MP0008438_abnormal_cutaneous_collagen1.01099968
71MP0001879_abnormal_lymphatic_vessel1.00440097
72MP0005451_abnormal_body_composition0.99586923
73MP0005666_abnormal_adipose_tissue0.99121399
74MP0000647_abnormal_sebaceous_gland0.97356342
75MP0009931_abnormal_skin_appearance0.96957859
76MP0001881_abnormal_mammary_gland0.96294464
77MP0000627_abnormal_mammary_gland0.94723332
78MP0001849_ear_inflammation0.93214752
79MP0000613_abnormal_salivary_gland0.92647926
80MP0005332_abnormal_amino_acid0.91339688
81MP0009379_abnormal_foot_pigmentation0.90844543
82MP0006138_congestive_heart_failure0.90296703
83MP0004043_abnormal_pH_regulation0.90255643
84MP0000003_abnormal_adipose_tissue0.89281363
85MP0003693_abnormal_embryo_hatching0.89267965
86MP0005220_abnormal_exocrine_pancreas0.86503269
87MP0002136_abnormal_kidney_physiology0.86209477
88MP0005375_adipose_tissue_phenotype0.86000602
89MP0003045_fibrosis0.85930161
90MP0003183_abnormal_peptide_metabolism0.84823458
91MP0003806_abnormal_nucleotide_metabolis0.83347684
92MP0001873_stomach_inflammation0.82911699
93MP0005167_abnormal_blood-brain_barrier0.81697669
94MP0002006_tumorigenesis0.79722550
95MP0001756_abnormal_urination0.78658380
96MP0001958_emphysema0.78641659
97MP0000367_abnormal_coat/_hair0.78013726
98MP0000477_abnormal_intestine_morphology0.77377123
99MP0005623_abnormal_meninges_morphology0.77198964
100MP0003943_abnormal_hepatobiliary_system0.76718906
101MP0003315_abnormal_perineum_morphology0.76249414
102MP0000534_abnormal_ureter_morphology0.75762847
103MP0001730_embryonic_growth_arrest0.75694242
104MP0003091_abnormal_cell_migration0.75449386
105MP0005670_abnormal_white_adipose0.74561149
106MP0000470_abnormal_stomach_morphology0.74234887
107MP0001243_abnormal_dermal_layer0.73597539
108MP0002249_abnormal_larynx_morphology0.72649684
109MP0010155_abnormal_intestine_physiology0.72577260
110MP0004233_abnormal_muscle_weight0.71373726
111MP0001664_abnormal_digestion0.71155106
112MP0002086_abnormal_extraembryonic_tissu0.70924482
113MP0000609_abnormal_liver_physiology0.69613237
114MP0004957_abnormal_blastocyst_morpholog0.69433272
115MP0002009_preneoplasia0.69062949
116MP0000490_abnormal_crypts_of0.68140955
117MP0003878_abnormal_ear_physiology0.67731293
118MP0005377_hearing/vestibular/ear_phenot0.67731293
119MP0000678_abnormal_parathyroid_gland0.67087046
120MP0002089_abnormal_postnatal_growth/wei0.66723995
121MP0002168_other_aberrant_phenotype0.65486244
122MP0002118_abnormal_lipid_homeostasis0.65327708
123MP0000163_abnormal_cartilage_morphology0.64846689
124MP0000767_abnormal_smooth_muscle0.64504716
125MP0003115_abnormal_respiratory_system0.63775238
126MP0009672_abnormal_birth_weight0.63663447
127MP0002282_abnormal_trachea_morphology0.63480569
128MP0003868_abnormal_feces_composition0.62999783
129MP0000858_altered_metastatic_potential0.62847277
130MP0002111_abnormal_tail_morphology0.62721258
131MP0005636_abnormal_mineral_homeostasis0.62424856
132MP0001851_eye_inflammation0.62148828
133MP0003866_abnormal_defecation0.59765574
134MP0000465_gastrointestinal_hemorrhage0.59537095
135MP0005621_abnormal_cell_physiology0.59321231
136MP0001661_extended_life_span0.58786540
137MP0000432_abnormal_head_morphology0.57902397

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.83446681
2Onycholysis (HP:0001806)4.50698779
3Abnormal pancreas size (HP:0012094)4.48879616
4Atrophic scars (HP:0001075)4.20299799
5Milia (HP:0001056)4.18960040
6Hepatoblastoma (HP:0002884)4.11149931
7Abnormality of nail color (HP:0100643)3.91580498
8Long foot (HP:0001833)3.46601570
9Neoplasm of the adrenal cortex (HP:0100641)3.41847633
10Advanced eruption of teeth (HP:0006288)3.28682260
11Plantar hyperkeratosis (HP:0007556)3.24293807
12Distal lower limb muscle weakness (HP:0009053)3.22281685
13Neonatal hypoglycemia (HP:0001998)3.18867689
14Fragile nails (HP:0001808)3.02400986
15Flat acetabular roof (HP:0003180)2.99175993
16Abnormality of the salivary glands (HP:0010286)2.88078246
17Germ cell neoplasia (HP:0100728)2.80479698
18Abnormality of glutamine family amino acid metabolism (HP:0010902)2.75082446
19Abnormal glucose tolerance (HP:0001952)2.75008206
20Alopecia of scalp (HP:0002293)2.72534591
21Woolly hair (HP:0002224)2.71731512
22Enlarged kidneys (HP:0000105)2.71465861
23Overgrowth (HP:0001548)2.69090142
24Selective tooth agenesis (HP:0001592)2.67429706
25Intrahepatic cholestasis (HP:0001406)2.63940094
26Hyperactive renin-angiotensin system (HP:0000841)2.61190196
27Esophageal varix (HP:0002040)2.60750492
28Fragile skin (HP:0001030)2.56895286
29Ridged nail (HP:0001807)2.56300821
30Pili torti (HP:0003777)2.54756159
31Diastasis recti (HP:0001540)2.52482987
32Pterygium (HP:0001059)2.48545398
33Short nail (HP:0001799)2.47206295
34Broad face (HP:0000283)2.47142566
35Vascular calcification (HP:0004934)2.46474592
36Abnormality of the distal phalanx of the thumb (HP:0009617)2.45743184
37Ventricular tachycardia (HP:0004756)2.45326064
38Focal segmental glomerulosclerosis (HP:0000097)2.43339175
39Abnormality of monocarboxylic acid metabolism (HP:0010996)2.43088915
40Cardiovascular calcification (HP:0011915)2.41963392
41Congenital ichthyosiform erythroderma (HP:0007431)2.41361422
42Sparse eyelashes (HP:0000653)2.40348026
43Abnormality of the distal phalanges of the toes (HP:0010182)2.36712808
44Abnormality of proline metabolism (HP:0010907)2.33692554
45Hydroxyprolinuria (HP:0003080)2.33692554
46Osteolytic defects of the phalanges of the hand (HP:0009771)2.33644259
47Osteolytic defects of the hand bones (HP:0009699)2.33644259
48Hypoplasia of dental enamel (HP:0006297)2.30710716
49Ankyloglossia (HP:0010296)2.27752592
50Nail dystrophy (HP:0008404)2.25896128
51Abnormality of the fingertips (HP:0001211)2.25635197
52Bronchomalacia (HP:0002780)2.23820483
53Popliteal pterygium (HP:0009756)2.22941135
54Abnormality of the dental root (HP:0006486)2.21686406
55Taurodontia (HP:0000679)2.21686406
56Abnormality of permanent molar morphology (HP:0011071)2.21686406
57Hypotrichosis (HP:0001006)2.20861040
58Hyperacusis (HP:0010780)2.20723332
59Thin bony cortex (HP:0002753)2.20365050
60Palmoplantar hyperkeratosis (HP:0000972)2.20164155
61Ileus (HP:0002595)2.19988653
62Palmar hyperkeratosis (HP:0010765)2.18251985
63Increased connective tissue (HP:0009025)2.16712763
64Trismus (HP:0000211)2.14926877
65Abnormality of chloride homeostasis (HP:0011422)2.13808490
66Erythema (HP:0010783)2.13676858
67Glomerulosclerosis (HP:0000096)2.13492599
68Abnormality of molar morphology (HP:0011070)2.10863358
69Abnormality of molar (HP:0011077)2.10863358
70Absent eyelashes (HP:0000561)2.10822534
71Abnormality of purine metabolism (HP:0004352)2.09744378
72Sparse scalp hair (HP:0002209)2.08035145
73Abnormal vertebral ossification (HP:0100569)2.07965776
74Xanthomatosis (HP:0000991)2.06547013
75Malnutrition (HP:0004395)2.05880672
76Abnormality of the dental pulp (HP:0006479)2.04642264
77Hyporeflexia of lower limbs (HP:0002600)2.01920534
78Abdominal distention (HP:0003270)2.01162969
79Micronodular cirrhosis (HP:0001413)1.99755957
80Septate vagina (HP:0001153)1.99704207
81Dehydration (HP:0001944)1.99463505
82Deep venous thrombosis (HP:0002625)1.98566021
83Oligodontia (HP:0000677)1.97948159
84Fat malabsorption (HP:0002630)1.97066877
85Gout (HP:0001997)1.97039387
86Aortic aneurysm (HP:0004942)1.96801529
87Sparse lateral eyebrow (HP:0005338)1.95649838
88Abnormality of the gastric mucosa (HP:0004295)1.95207583
89Abnormality of the nasal septum (HP:0000419)1.94987400
90Hypoglycemic coma (HP:0001325)1.94939581
91Distal lower limb amyotrophy (HP:0008944)1.93419666
92Amelogenesis imperfecta (HP:0000705)1.89924073
93Villous atrophy (HP:0011473)1.89051824
94Abnormality of small intestinal villus morphology (HP:0011472)1.89051824
95Aplasia cutis congenita (HP:0001057)1.87437991
96Increased IgE level (HP:0003212)1.86811334
97Abnormality of oral frenula (HP:0000190)1.85921796
98Rectal prolapse (HP:0002035)1.85401642
99Lip pit (HP:0100267)1.85373026
100Cervical subluxation (HP:0003308)1.84288682
101Curly hair (HP:0002212)1.84275587
102Hyperkalemia (HP:0002153)1.83784447
103Nasolacrimal duct obstruction (HP:0000579)1.83493178
104Mildly elevated creatine phosphokinase (HP:0008180)1.81518416
105Abnormal blistering of the skin (HP:0008066)1.80876399
106Abnormality of the labia majora (HP:0012881)1.79558219
107Ureteral duplication (HP:0000073)1.79509122
108Abnormality of carpal bone ossification (HP:0006257)1.78852325
109Interstitial pulmonary disease (HP:0006530)1.78366864
110Broad metatarsal (HP:0001783)1.77514727
111Hemorrhage of the eye (HP:0011885)1.75379103
112Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.75168077
113Abnormal hemoglobin (HP:0011902)1.72866119
114Shallow orbits (HP:0000586)1.72595171
115Premature rupture of membranes (HP:0001788)1.72540828
116Abnormal foot bone ossification (HP:0010675)1.72308567
117Hypoplastic labia majora (HP:0000059)1.72046980
118Aortic dissection (HP:0002647)1.70506601
119Neonatal short-limb short stature (HP:0008921)1.69980700
120Conjugated hyperbilirubinemia (HP:0002908)1.69741397
121Deviation of the thumb (HP:0009603)1.69638588
122Ectropion (HP:0000656)1.69222351
123Abnormal tarsal ossification (HP:0008369)1.68594304
124Hypobetalipoproteinemia (HP:0003563)1.67190967
125Muscle fiber splitting (HP:0003555)1.67096200
126Decreased circulating renin level (HP:0003351)1.66617461
127Epidermoid cyst (HP:0200040)1.65680254
128Neonatal death (HP:0003811)1.64369436
129Axonal loss (HP:0003447)1.64288118
130Natal tooth (HP:0000695)1.64270837
131Abnormal hair laboratory examination (HP:0003328)1.64062359
132Abnormality of the intrinsic pathway (HP:0010989)1.63534074
133Depressed nasal tip (HP:0000437)1.63360194
134Distal upper limb amyotrophy (HP:0007149)1.62078360
135Upper limb amyotrophy (HP:0009129)1.62078360
136Potter facies (HP:0002009)1.61917972
137Facial shape deformation (HP:0011334)1.61917972
138Thick nail (HP:0001805)1.61817704
139Abnormality of nucleobase metabolism (HP:0010932)1.61636614
140Abnormality of the lacrimal duct (HP:0011481)1.61142633
141Protrusio acetabuli (HP:0003179)1.60437626
142Abnormal ossification of hand bones (HP:0005921)1.60116477
143Aneurysm (HP:0002617)1.60032564
144Lymphangioma (HP:0100764)1.59883150
145Ureteral stenosis (HP:0000071)1.59733022
146Abnormality of the 2nd finger (HP:0004100)1.59613012
147Hyperuricemia (HP:0002149)1.59073381
148Increased purine levels (HP:0004368)1.59073381
149Acanthosis nigricans (HP:0000956)1.58260882
150Myocardial infarction (HP:0001658)1.57740435
151Abnormality of the middle phalanges of the toes (HP:0010183)1.57646262
152Corneal erosion (HP:0200020)1.56935095
153Hypolipoproteinemia (HP:0010981)1.56651104

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.72755488
2TIE13.84880079
3LATS13.50602455
4RIPK13.25114242
5FRK3.13523043
6SMG12.89370651
7PRKG22.81898799
8MST42.79442594
9MST1R2.55636441
10MAP3K32.29147892
11SIK12.26600161
12ERN12.16385404
13FER2.13891869
14EPHB21.95861365
15PTK61.94782267
16TTN1.94642089
17INSRR1.66699020
18ICK1.65524649
19MYLK1.65048274
20LMTK21.60193988
21STK38L1.55092499
22MAP2K21.54857961
23PIK3CA1.54105276
24PTK21.53420442
25MAPKAPK31.52182978
26RPS6KB21.47021404
27EPHA31.35354899
28TRPM71.33865588
29MET1.33408052
30TGFBR21.31802636
31TRIB31.26798937
32FGFR41.24987983
33LATS21.21927502
34AKT31.21490423
35STK101.21366677
36STK241.20935837
37LRRK21.20560152
38NUAK11.19639866
39EPHB11.17808490
40PKN21.17065545
41MAP3K21.15466937
42TAOK31.12750220
43DDR21.09116652
44BMX1.08999875
45PRPF4B1.08324495
46WNK41.07634946
47PDGFRA1.06467779
48MAP3K90.99706308
49GRK10.93133206
50NME10.91063100
51PAK40.90506401
52PBK0.88980482
53NEK90.88266974
54PIK3CG0.87838173
55PRKCI0.86866816
56CAMK1D0.85621408
57STK30.85442687
58TGFBR10.82392252
59DMPK0.82387078
60EEF2K0.82062931
61MAP2K10.81773079
62MAP3K120.81052839
63MAP2K30.77552336
64NME20.76150128
65STK380.74786540
66SCYL20.73702690
67MAP3K70.71507516
68CDC42BPA0.70553335
69KDR0.69889171
70MAP3K60.69567783
71PRKD20.68906852
72SIK30.67534469
73RPS6KA20.67482060
74CAMK1G0.67107093
75FGFR10.66775481
76PDGFRB0.66034858
77NEK60.65468537
78STK160.64929075
79FGFR30.64239304
80ERBB40.64151102
81PAK20.61954480
82ERBB20.60277893
83FGFR20.60065102
84MELK0.59396590
85CDK60.59297494
86NTRK10.56992631
87CDK120.55434476
88BCKDK0.53631704
89CHUK0.53163190
90PDK20.52692307
91PRKAA20.52505358
92MTOR0.52319635
93NLK0.51881212
94CAMK2D0.51815878
95TESK10.51306329
96IRAK30.51155354
97MAP3K130.50545164
98RPS6KA40.50028972
99FLT30.49947909
100CDK70.49586439
101CAMK2G0.48807915
102ROCK10.48511255
103STK390.48339444
104TAOK10.47703839
105DYRK1B0.46468861
106MAPK150.45798992
107PAK30.44953016
108CAMK2B0.42614533
109TEC0.42411045
110ZAK0.42051625
111MAP3K10.40662504
112SGK30.39913276
113GSK3A0.39486430
114BRD40.39237524
115TTK0.38198449
116MARK20.37234054
117JAK10.36369115
118CDK90.35959865
119MAP3K140.35656097
120HIPK20.34457622
121PDPK10.34207295
122MAP3K80.34206788
123MKNK20.33726986
124OXSR10.33504482
125ERBB30.32035270
126BRSK20.31780487
127MAPK110.31608223
128JAK30.31126660
129PRKD10.30928268
130MAPKAPK20.30881988
131WNK10.30753890
132PRKCE0.30149420
133MAP2K60.29997249
134MAP3K100.29564823
135AKT20.29111191
136PRKD30.27321958
137RET0.26360949
138EIF2AK30.26133268
139RPS6KC10.25440812
140RPS6KL10.25440812

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.68315361
2Caffeine metabolism_Homo sapiens_hsa002322.27869880
3Sulfur metabolism_Homo sapiens_hsa009202.21311220
4ECM-receptor interaction_Homo sapiens_hsa045122.13113470
5Fat digestion and absorption_Homo sapiens_hsa049752.08176837
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06578404
7Vitamin digestion and absorption_Homo sapiens_hsa049772.02481829
8Tryptophan metabolism_Homo sapiens_hsa003801.95759766
9Fatty acid degradation_Homo sapiens_hsa000711.95594183
10Pentose and glucuronate interconversions_Homo sapiens_hsa000401.92776998
11Maturity onset diabetes of the young_Homo sapiens_hsa049501.87309235
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.78311539
13Chemical carcinogenesis_Homo sapiens_hsa052041.74811256
14Histidine metabolism_Homo sapiens_hsa003401.73268445
15Protein digestion and absorption_Homo sapiens_hsa049741.72720952
16Mineral absorption_Homo sapiens_hsa049781.69402797
17Bile secretion_Homo sapiens_hsa049761.67941988
18Adherens junction_Homo sapiens_hsa045201.65917482
19PPAR signaling pathway_Homo sapiens_hsa033201.64030158
20Starch and sucrose metabolism_Homo sapiens_hsa005001.62871617
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.58667826
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53318875
23Lysine degradation_Homo sapiens_hsa003101.48378155
24Arginine biosynthesis_Homo sapiens_hsa002201.44498662
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42737597
26Selenocompound metabolism_Homo sapiens_hsa004501.42697096
27Notch signaling pathway_Homo sapiens_hsa043301.36912132
28Small cell lung cancer_Homo sapiens_hsa052221.35466530
29ABC transporters_Homo sapiens_hsa020101.34742215
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.33165237
31Amoebiasis_Homo sapiens_hsa051461.30574450
32Phenylalanine metabolism_Homo sapiens_hsa003601.27679988
33Complement and coagulation cascades_Homo sapiens_hsa046101.27401720
34Retinol metabolism_Homo sapiens_hsa008301.25829387
35Focal adhesion_Homo sapiens_hsa045101.25411428
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.24388273
37Tight junction_Homo sapiens_hsa045301.23512173
38Nitrogen metabolism_Homo sapiens_hsa009101.23239846
39beta-Alanine metabolism_Homo sapiens_hsa004101.21880416
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.21758438
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20511312
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.19405327
43Bladder cancer_Homo sapiens_hsa052191.16218585
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14663837
45Renin-angiotensin system_Homo sapiens_hsa046141.13524657
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.11828382
47Peroxisome_Homo sapiens_hsa041461.10698519
48Glutathione metabolism_Homo sapiens_hsa004801.10550065
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.08349789
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03043732
51Fatty acid metabolism_Homo sapiens_hsa012121.01793074
52Galactose metabolism_Homo sapiens_hsa000521.00570603
53Proteoglycans in cancer_Homo sapiens_hsa052050.97266628
54Chronic myeloid leukemia_Homo sapiens_hsa052200.96256343
55Propanoate metabolism_Homo sapiens_hsa006400.94295468
56Pentose phosphate pathway_Homo sapiens_hsa000300.94288239
57Endometrial cancer_Homo sapiens_hsa052130.92260930
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89509361
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89236178
60Hippo signaling pathway_Homo sapiens_hsa043900.88886634
61Thyroid hormone synthesis_Homo sapiens_hsa049180.84325265
62Biosynthesis of amino acids_Homo sapiens_hsa012300.83233178
63Renal cell carcinoma_Homo sapiens_hsa052110.82798843
64Acute myeloid leukemia_Homo sapiens_hsa052210.82063087
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80014719
66Insulin resistance_Homo sapiens_hsa049310.78294271
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77708173
68Inositol phosphate metabolism_Homo sapiens_hsa005620.77424890
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76667807
70Insulin signaling pathway_Homo sapiens_hsa049100.75865037
71Butanoate metabolism_Homo sapiens_hsa006500.75785063
72Other glycan degradation_Homo sapiens_hsa005110.75695002
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74718330
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72891614
75Basal cell carcinoma_Homo sapiens_hsa052170.72637010
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.70982137
77Tyrosine metabolism_Homo sapiens_hsa003500.70224292
78ErbB signaling pathway_Homo sapiens_hsa040120.68749270
79Hepatitis C_Homo sapiens_hsa051600.68695298
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68329713
81Linoleic acid metabolism_Homo sapiens_hsa005910.68020555
82AMPK signaling pathway_Homo sapiens_hsa041520.67341700
83Pancreatic secretion_Homo sapiens_hsa049720.66737871
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66479021
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66105935
86African trypanosomiasis_Homo sapiens_hsa051430.65519087
87Fructose and mannose metabolism_Homo sapiens_hsa000510.65221507
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64390733
89Pancreatic cancer_Homo sapiens_hsa052120.64338125
90Arginine and proline metabolism_Homo sapiens_hsa003300.64098212
91Glycerolipid metabolism_Homo sapiens_hsa005610.62606722
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62025081
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61307158
94Toxoplasmosis_Homo sapiens_hsa051450.60738422
95Choline metabolism in cancer_Homo sapiens_hsa052310.60447589
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59523180
97Vitamin B6 metabolism_Homo sapiens_hsa007500.59307559
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58868672
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58482670
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57428493
101Folate biosynthesis_Homo sapiens_hsa007900.56809165
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.56263555
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56191785
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55594632
105VEGF signaling pathway_Homo sapiens_hsa043700.54850962
106TGF-beta signaling pathway_Homo sapiens_hsa043500.54115441
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52169841
108Dilated cardiomyopathy_Homo sapiens_hsa054140.50993270
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50838251
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49785611
111Sphingolipid metabolism_Homo sapiens_hsa006000.49675893
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49213277
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47746227
114Vibrio cholerae infection_Homo sapiens_hsa051100.47432739
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47384043
116Circadian rhythm_Homo sapiens_hsa047100.46690124
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46668250
118Pyruvate metabolism_Homo sapiens_hsa006200.45315929
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44926776
120Carbon metabolism_Homo sapiens_hsa012000.44911564
121Prostate cancer_Homo sapiens_hsa052150.44778534
122Gastric acid secretion_Homo sapiens_hsa049710.43003002
123Thyroid cancer_Homo sapiens_hsa052160.42686953
124N-Glycan biosynthesis_Homo sapiens_hsa005100.41544486
125MicroRNAs in cancer_Homo sapiens_hsa052060.41030381
126Platelet activation_Homo sapiens_hsa046110.39549229
127Pathways in cancer_Homo sapiens_hsa052000.37817763
128Arachidonic acid metabolism_Homo sapiens_hsa005900.37517115
129Glucagon signaling pathway_Homo sapiens_hsa049220.36164547
130Fatty acid biosynthesis_Homo sapiens_hsa000610.35800683
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.34696024

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