ARHGEF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.94427509
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.45879254
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.36291147
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.36291147
5antigen processing and presentation of endogenous antigen (GO:0019883)5.17030385
6regulation of B cell receptor signaling pathway (GO:0050855)4.97239088
7negative regulation of cell killing (GO:0031342)4.78248793
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.78248793
9negative regulation of erythrocyte differentiation (GO:0045647)4.57667178
10regulation of gamma-delta T cell differentiation (GO:0045586)4.49449544
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.48260822
12positive regulation of granulocyte differentiation (GO:0030854)4.43769062
13positive regulation of B cell differentiation (GO:0045579)4.39875720
14response to interleukin-15 (GO:0070672)4.35771041
15definitive hemopoiesis (GO:0060216)4.16602849
16regulation of gamma-delta T cell activation (GO:0046643)4.16542869
17megakaryocyte development (GO:0035855)4.09335141
18regulation of B cell differentiation (GO:0045577)3.97833944
19negative thymic T cell selection (GO:0045060)3.95423206
20negative T cell selection (GO:0043383)3.93631203
21B cell receptor signaling pathway (GO:0050853)3.91761186
22detection of other organism (GO:0098543)3.90633263
23leukocyte aggregation (GO:0070486)3.90350960
24negative regulation of T cell mediated immunity (GO:0002710)3.87445737
25negative regulation of phagocytosis (GO:0050765)3.86029741
26positive thymic T cell selection (GO:0045059)3.80600425
27angiogenesis involved in wound healing (GO:0060055)3.78065306
28activated T cell proliferation (GO:0050798)3.76445939
29detection of bacterium (GO:0016045)3.73117450
30negative regulation of lymphocyte mediated immunity (GO:0002707)3.66853391
31regulation of granulocyte differentiation (GO:0030852)3.54330565
32myeloid dendritic cell activation (GO:0001773)3.48580367
33regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.47539913
34regulation of interleukin-12 biosynthetic process (GO:0045075)3.42205685
35microglial cell activation (GO:0001774)3.41078205
36Arp2/3 complex-mediated actin nucleation (GO:0034314)3.39523920
37cellular response to interleukin-15 (GO:0071350)3.39210901
38NIK/NF-kappaB signaling (GO:0038061)3.39073662
39pinocytosis (GO:0006907)3.38954475
40negative regulation of leukocyte mediated immunity (GO:0002704)3.37604067
41regulation of T cell tolerance induction (GO:0002664)3.36564752
42regulation of interferon-beta biosynthetic process (GO:0045357)3.35843015
43macrophage activation involved in immune response (GO:0002281)3.35775313
44positive regulation by symbiont of host defense response (GO:0052509)3.33878617
45modulation by symbiont of host defense response (GO:0052031)3.33878617
46modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.33878617
47modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.33878617
48positive regulation by organism of defense response of other organism involved in symbiotic interact3.33878617
49modulation by symbiont of host immune response (GO:0052553)3.33878617
50T cell migration (GO:0072678)3.32900008
51interferon-gamma production (GO:0032609)3.31016205
52mature B cell differentiation (GO:0002335)3.30458636
53neutrophil activation involved in immune response (GO:0002283)3.30004805
54antigen processing and presentation via MHC class Ib (GO:0002475)3.29445842
55immunoglobulin mediated immune response (GO:0016064)3.28593158
56T cell homeostasis (GO:0043029)3.27939332
57detection of external biotic stimulus (GO:0098581)3.27466131
58mast cell activation (GO:0045576)3.25132919
59regulation of alpha-beta T cell proliferation (GO:0046640)3.24977817
60Peyers patch development (GO:0048541)3.19043952
61mucosal-associated lymphoid tissue development (GO:0048537)3.19043952
62thymic T cell selection (GO:0045061)3.17538989
63response to muramyl dipeptide (GO:0032495)3.15384759
64response to host immune response (GO:0052572)3.13242567
65response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.13242567
66regulation of response to interferon-gamma (GO:0060330)3.12552749
67regulation of necroptotic process (GO:0060544)3.12277726
68regulation of mast cell degranulation (GO:0043304)3.11448235
69negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.10386272
70cellular response to zinc ion (GO:0071294)3.10364704
71T cell selection (GO:0045058)3.09091734
72neutrophil activation (GO:0042119)3.08923726
73lymphocyte homeostasis (GO:0002260)3.08865387
74positive T cell selection (GO:0043368)3.07454961
75regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.06609418
76T cell costimulation (GO:0031295)3.04640205
77negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.04449295
78regulation of T cell receptor signaling pathway (GO:0050856)3.04003498
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.02896904
80detection of molecule of bacterial origin (GO:0032490)3.01399974
81lymphocyte costimulation (GO:0031294)3.00246325
82B cell homeostasis (GO:0001782)2.98787265
83regulation of tolerance induction (GO:0002643)2.98490531
84regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.98041839
85hepatocyte apoptotic process (GO:0097284)2.97952610
86positive regulation of alpha-beta T cell proliferation (GO:0046641)2.97415865
87dendritic cell chemotaxis (GO:0002407)2.97021415
88response to type I interferon (GO:0034340)2.96082813
89positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.96080735
90dendritic cell migration (GO:0036336)2.94963260
91regulation of myeloid leukocyte mediated immunity (GO:0002886)2.94571758
92positive regulation of interferon-alpha production (GO:0032727)2.94475113
93mature B cell differentiation involved in immune response (GO:0002313)2.94416027
94antigen receptor-mediated signaling pathway (GO:0050851)2.94231833
95detection of biotic stimulus (GO:0009595)2.93537839
96negative regulation of interleukin-12 production (GO:0032695)2.93452102
97interferon-gamma-mediated signaling pathway (GO:0060333)2.93197308
98cellular response to type I interferon (GO:0071357)2.93008229
99type I interferon signaling pathway (GO:0060337)2.93008229
100tolerance induction (GO:0002507)2.92444239
101positive regulation of mast cell activation (GO:0033005)2.92045927
102negative regulation of granulocyte differentiation (GO:0030853)2.91184773
103myeloid cell activation involved in immune response (GO:0002275)2.90946112
104cellular extravasation (GO:0045123)2.90492616
105response to host (GO:0075136)2.90400205
106response to host defenses (GO:0052200)2.90400205
107response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.90400205
108myeloid dendritic cell differentiation (GO:0043011)2.90333957
109regulation of interleukin-2 biosynthetic process (GO:0045076)2.89345729
110positive regulation of natural killer cell differentiation (GO:0032825)2.87896998
111negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.87300826
112regulation of mast cell activation involved in immune response (GO:0033006)2.86541991
113T cell receptor signaling pathway (GO:0050852)2.84736450
114regulation of interferon-alpha production (GO:0032647)2.84178900
115regulation of regulatory T cell differentiation (GO:0045589)2.83185623
116positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.83063164
117leukocyte degranulation (GO:0043299)2.82398849
118leukocyte homeostasis (GO:0001776)2.82203227
119T cell proliferation (GO:0042098)2.81571101
120negative regulation of necroptotic process (GO:0060546)2.81539581
121granulocyte activation (GO:0036230)2.81182843
122JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.81069786
123necroptotic process (GO:0070266)2.80971047
124negative regulation of B cell proliferation (GO:0030889)2.80406041
125positive regulation of isotype switching (GO:0045830)2.80325403
126negative regulation of T-helper cell differentiation (GO:0045623)2.80099503
127negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.80099503
128response to protozoan (GO:0001562)2.79997030
129regulation of leukocyte degranulation (GO:0043300)2.79610985
130positive regulation of interleukin-2 production (GO:0032743)2.79233883
131macrophage activation (GO:0042116)2.78857338
132embryonic hemopoiesis (GO:0035162)2.77278758
133positive regulation of antigen processing and presentation (GO:0002579)2.75401413
134positive regulation of tolerance induction (GO:0002645)2.74474650
135response to peptidoglycan (GO:0032494)2.73969208
136regulation of mast cell activation (GO:0033003)2.73698222
137natural killer cell differentiation (GO:0001779)2.72760702
138regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.72055258
139lymph node development (GO:0048535)2.70539203
140defense response to protozoan (GO:0042832)2.68403454
141germinal center formation (GO:0002467)2.66624295
142natural killer cell activation (GO:0030101)2.65662788

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.96317709
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.86272121
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.85915215
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.33227015
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.98480344
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.85208214
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.73491134
8SCL_19346495_ChIP-Seq_HPC-7_Human3.57017961
9E2F7_22180533_ChIP-Seq_HELA_Human3.52308816
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.18918762
11RUNX_20019798_ChIP-Seq_JUKART_Human3.13159056
12* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.10770603
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.08562369
14MYB_21317192_ChIP-Seq_ERMYB_Mouse3.03012195
15* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.02921253
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.92965839
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.90985819
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.90080270
19* MYB_26560356_Chip-Seq_TH2_Human2.72023244
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.67577137
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.67252522
22MAF_26560356_Chip-Seq_TH1_Human2.52132420
23VDR_21846776_ChIP-Seq_THP-1_Human2.46126767
24SPI1_23547873_ChIP-Seq_NB4_Human2.44769497
25MYC_22102868_ChIP-Seq_BL_Human2.41178317
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.40166968
27MYB_26560356_Chip-Seq_TH1_Human2.34895127
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.32561334
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28966066
30RUNX1_22412390_ChIP-Seq_EML_Mouse2.16113113
31VDR_24763502_ChIP-Seq_THP-1_Human2.09379451
32BRD4_27068464_Chip-Seq_AML-cells_Mouse2.07736723
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.06928559
34* SPI1_23127762_ChIP-Seq_K562_Human2.04874933
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.04694410
36SMAD_19615063_ChIP-ChIP_OVARY_Human2.01906667
37UTX_26944678_Chip-Seq_JUKART_Human1.96757676
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.90109185
39TCF7_22412390_ChIP-Seq_EML_Mouse1.88174019
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.80124922
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79737259
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.72930272
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71605499
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69652874
45* GATA3_27048872_Chip-Seq_THYMUS_Human1.63244268
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61408126
47PU_27001747_Chip-Seq_BMDM_Mouse1.59612779
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59107441
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57646101
50PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55413324
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.53016737
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.50996920
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50386750
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49019664
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44242444
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43510041
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42363380
58MAF_26560356_Chip-Seq_TH2_Human1.39494930
59RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.38873240
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36484819
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36084042
62GATA1_22025678_ChIP-Seq_K562_Human1.34857280
63CIITA_25753668_ChIP-Seq_RAJI_Human1.33992643
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32998423
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32887928
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.28252131
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25808860
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24487536
69KDM2B_26808549_Chip-Seq_DND41_Human1.23971463
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.23929744
71GATA3_26560356_Chip-Seq_TH2_Human1.21755164
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18030625
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17903342
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14632656
75VDR_24787735_ChIP-Seq_THP-1_Human1.13869910
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10617957
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10074100
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05578800
79FOXM1_23109430_ChIP-Seq_U2OS_Human1.04090357
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04045950
81E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02302930
82KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02273416
83TFEB_21752829_ChIP-Seq_HELA_Human0.96220291
84ELK3_25401928_ChIP-Seq_HUVEC_Human0.96166421
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93221461
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91551639
87CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90685988
88* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89770704
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89409747
90GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88084052
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87737862
92GATA2_19941826_ChIP-Seq_K562_Human0.85529076
93ETS1_22383799_ChIP-Seq_G1ME_Mouse0.84816006
94VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82074566
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81702629
96PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79635640
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76582564
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75548262
99KDM2B_26808549_Chip-Seq_JURKAT_Human0.75508246
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.74827087
101NCOR1_26117541_ChIP-Seq_K562_Human0.74473728
102GATA1_19941826_ChIP-Seq_K562_Human0.73895955
103SPI1_20517297_ChIP-Seq_HL60_Human0.72001042
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.71649126
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71385542
106SMRT_27268052_Chip-Seq_Bcells_Human0.70920558
107IKZF1_21737484_ChIP-ChIP_HCT116_Human0.70863767
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70815643
109RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69582723
110TBX20_22328084_ChIP-Seq_HEART_Mouse0.63039617

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.47194896
2MP0000685_abnormal_immune_system3.39105174
3* MP0001800_abnormal_humoral_immune3.15714393
4MP0005671_abnormal_response_to3.13851895
5MP0002396_abnormal_hematopoietic_system3.02895208
6MP0001790_abnormal_immune_system2.92974445
7MP0005387_immune_system_phenotype2.92974445
8* MP0002452_abnormal_antigen_presenting2.83327895
9MP0005000_abnormal_immune_tolerance2.67792850
10* MP0002723_abnormal_immune_serum2.63890784
11* MP0002420_abnormal_adaptive_immunity2.62486761
12* MP0001819_abnormal_immune_cell2.60910225
13MP0003763_abnormal_thymus_physiology2.56659120
14MP0002166_altered_tumor_susceptibility2.54301586
15MP0002419_abnormal_innate_immunity2.53733600
16MP0009785_altered_susceptibility_to2.53727989
17MP0005025_abnormal_response_to2.51579474
18* MP0002398_abnormal_bone_marrow2.46416233
19MP0003436_decreased_susceptibility_to2.44695619
20MP0002148_abnormal_hypersensitivity_rea2.39989647
21MP0003303_peritoneal_inflammation2.38809118
22MP0005464_abnormal_platelet_physiology2.35746015
23* MP0000716_abnormal_immune_system2.22234422
24MP0004808_abnormal_hematopoietic_stem2.18896898
25MP0004510_myositis2.16095532
26MP0000689_abnormal_spleen_morphology2.01778844
27MP0002405_respiratory_system_inflammati2.01040544
28MP0006082_CNS_inflammation1.98586692
29MP0003724_increased_susceptibility_to1.97458576
30MP0002722_abnormal_immune_system1.97254911
31MP0002006_tumorigenesis1.95691592
32* MP0002429_abnormal_blood_cell1.88641486
33MP0001853_heart_inflammation1.87909314
34MP0010155_abnormal_intestine_physiology1.86802286
35MP0000703_abnormal_thymus_morphology1.78503266
36MP0003300_gastrointestinal_ulcer1.77982825
37MP0001873_stomach_inflammation1.74554821
38MP0001845_abnormal_inflammatory_respons1.65241000
39MP0001545_abnormal_hematopoietic_system1.64859956
40MP0005397_hematopoietic_system_phenotyp1.64859956
41MP0004947_skin_inflammation1.64464413
42MP0000465_gastrointestinal_hemorrhage1.59398774
43MP0005174_abnormal_tail_pigmentation1.59008140
44MP0009333_abnormal_splenocyte_physiolog1.55959479
45MP0005310_abnormal_salivary_gland1.45216828
46MP0003183_abnormal_peptide_metabolism1.44612085
47MP0005058_abnormal_lysosome_morphology1.42851219
48MP0005451_abnormal_body_composition1.41019061
49MP0009278_abnormal_bone_marrow1.38460505
50MP0001851_eye_inflammation1.32924401
51MP0003690_abnormal_glial_cell1.30413831
52MP0003172_abnormal_lysosome_physiology1.30360781
53MP0001533_abnormal_skeleton_physiology1.28978055
54MP0003866_abnormal_defecation1.24432503
55MP0002933_joint_inflammation1.23880021
56MP0000858_altered_metastatic_potential1.23424787
57MP0008469_abnormal_protein_level1.19085759
58MP0000490_abnormal_crypts_of1.18346918
59MP0004381_abnormal_hair_follicle1.17811737
60MP0004883_abnormal_blood_vessel1.16125415
61MP0000569_abnormal_digit_pigmentation1.15902689
62MP0006054_spinal_hemorrhage1.13989723
63MP0008260_abnormal_autophagy1.13610648
64MP0000343_altered_response_to1.12427710
65MP0004036_abnormal_muscle_relaxation1.12198372
66MP0010352_gastrointestinal_tract_polyps1.11823267
67MP0003646_muscle_fatigue1.08499237
68MP0003448_altered_tumor_morphology1.04128665
69MP0005670_abnormal_white_adipose1.04107260
70MP0005075_abnormal_melanosome_morpholog1.02090497
71MP0003828_pulmonary_edema1.01157317
72MP0003566_abnormal_cell_adhesion0.99674434
73MP0004484_altered_response_of0.98548167
74MP0004084_abnormal_cardiac_muscle0.97336854
75MP0003045_fibrosis0.97209872
76MP0005166_decreased_susceptibility_to0.96183279
77MP0003075_altered_response_to0.95894605
78MP0000015_abnormal_ear_pigmentation0.93982464
79MP0001986_abnormal_taste_sensitivity0.92814243
80MP0010307_abnormal_tumor_latency0.92519780
81MP0002132_abnormal_respiratory_system0.89915388
82MP0002998_abnormal_bone_remodeling0.89296843
83MP0003191_abnormal_cellular_cholesterol0.86172057
84MP0002019_abnormal_tumor_incidence0.85857219
85MP0002009_preneoplasia0.85399448
86MP0003279_aneurysm0.84794974
87MP0009115_abnormal_fat_cell0.83226878
88MP0004130_abnormal_muscle_cell0.82331717
89MP0008057_abnormal_DNA_replication0.81938001
90MP0001879_abnormal_lymphatic_vessel0.79545464
91MP0000604_amyloidosis0.79488012
92MP0000371_diluted_coat_color0.79159562
93MP0009764_decreased_sensitivity_to0.79083231
94MP0002095_abnormal_skin_pigmentation0.78870988
95MP0005164_abnormal_response_to0.78749598
96MP0005076_abnormal_cell_differentiation0.78723405
97MP0002971_abnormal_brown_adipose0.76430486
98MP0002332_abnormal_exercise_endurance0.75395861
99MP0008007_abnormal_cellular_replicative0.75382694
100MP0003943_abnormal_hepatobiliary_system0.74720034
101MP0004185_abnormal_adipocyte_glucose0.74282468
102MP0000249_abnormal_blood_vessel0.73547358
103MP0000749_muscle_degeneration0.71544308
104MP0003656_abnormal_erythrocyte_physiolo0.71337106
105MP0004145_abnormal_muscle_electrophysio0.70460779
106MP0004087_abnormal_muscle_fiber0.69103876
107MP0005535_abnormal_body_temperature0.69030993
108MP0005390_skeleton_phenotype0.67908451
109MP0003221_abnormal_cardiomyocyte_apopto0.67076953
110MP0009765_abnormal_xenobiotic_induced0.66282339
111MP0000767_abnormal_smooth_muscle0.65860525
112MP0000759_abnormal_skeletal_muscle0.64772897
113MP0005375_adipose_tissue_phenotype0.64235406
114MP0008961_abnormal_basal_metabolism0.63287697
115MP0004264_abnormal_extraembryonic_tissu0.61829894
116MP0003795_abnormal_bone_structure0.58443606
117MP0001663_abnormal_digestive_system0.57922036
118MP0003077_abnormal_cell_cycle0.57424663
119MP0010094_abnormal_chromosome_stability0.57319440
120MP0010630_abnormal_cardiac_muscle0.56821342
121MP0002877_abnormal_melanocyte_morpholog0.55872178
122MP0009763_increased_sensitivity_to0.55792314
123MP0003091_abnormal_cell_migration0.53798756
124MP0003693_abnormal_embryo_hatching0.52282805
125MP0005666_abnormal_adipose_tissue0.51709162

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.87256061
2Myositis (HP:0100614)4.77806074
3Recurrent bacterial skin infections (HP:0005406)4.63676805
4Elevated erythrocyte sedimentation rate (HP:0003565)4.50202460
5Recurrent viral infections (HP:0004429)4.40770518
6Eczematoid dermatitis (HP:0000976)4.36596403
7Recurrent fungal infections (HP:0002841)4.18911533
8IgM deficiency (HP:0002850)4.11950064
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.94882551
10Stomatitis (HP:0010280)3.88931177
11Thrombocytosis (HP:0001894)3.87062662
12Agammaglobulinemia (HP:0004432)3.76743555
13Chronic otitis media (HP:0000389)3.70303381
14Panhypogammaglobulinemia (HP:0003139)3.58593425
15Cellulitis (HP:0100658)3.46976793
16Meningitis (HP:0001287)3.43474718
17Colitis (HP:0002583)3.38659707
18Recurrent skin infections (HP:0001581)3.37748792
19Recurrent bronchitis (HP:0002837)3.37577179
20Nasal polyposis (HP:0100582)3.35091290
21Orchitis (HP:0100796)3.33382720
22Recurrent cutaneous fungal infections (HP:0011370)3.30878877
23Chronic mucocutaneous candidiasis (HP:0002728)3.30878877
24Inflammation of the large intestine (HP:0002037)3.27915535
25Spontaneous hematomas (HP:0007420)3.27571841
26B lymphocytopenia (HP:0010976)3.25622903
27Abnormality of B cell number (HP:0010975)3.25622903
28Retrobulbar optic neuritis (HP:0100654)3.22926634
29Optic neuritis (HP:0100653)3.22926634
30Thyroiditis (HP:0100646)3.20406865
31Abnormality of T cells (HP:0002843)3.13137086
32Abnormality of the nasal mucosa (HP:0000433)3.11977734
33Gastrointestinal inflammation (HP:0004386)3.11014575
34Mediastinal lymphadenopathy (HP:0100721)3.08751062
35T lymphocytopenia (HP:0005403)3.06979712
36Abnormality of T cell number (HP:0011839)3.03945742
37Vasculitis (HP:0002633)3.03540502
38Arterial thrombosis (HP:0004420)3.01568378
39Abnormality of T cell physiology (HP:0011840)3.01465979
40Nemaline bodies (HP:0003798)2.98662787
41Exercise-induced myalgia (HP:0003738)2.90649485
42Muscle fiber inclusion bodies (HP:0100299)2.90487738
43Abnormality of the fingertips (HP:0001211)2.88536703
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.88303564
45Chronic obstructive pulmonary disease (HP:0006510)2.87866600
46Obstructive lung disease (HP:0006536)2.87866600
47Increased cerebral lipofuscin (HP:0011813)2.87442299
48Gastrointestinal stroma tumor (HP:0100723)2.86433692
49Papilledema (HP:0001085)2.84927578
50Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.83465875
51Autoimmune hemolytic anemia (HP:0001890)2.83461380
52Eosinophilia (HP:0001880)2.80639667
53Abnormality of macrophages (HP:0004311)2.76631776
54Leukocytosis (HP:0001974)2.69284676
55Prolonged bleeding time (HP:0003010)2.69226785
56Hematochezia (HP:0002573)2.66723431
57Chest pain (HP:0100749)2.65866279
58Chronic diarrhea (HP:0002028)2.63929877
59Lymphopenia (HP:0001888)2.61673666
60Osteomyelitis (HP:0002754)2.60207240
61Recurrent gram-negative bacterial infections (HP:0005420)2.59790705
62Abnormality of eosinophils (HP:0001879)2.56678471
63Disinhibition (HP:0000734)2.52099748
64Abnormality of cells of the lymphoid lineage (HP:0012140)2.52092369
65Granulocytopenia (HP:0001913)2.51575047
66Keratoconjunctivitis sicca (HP:0001097)2.50678413
67Papilloma (HP:0012740)2.50080145
68Verrucae (HP:0200043)2.50080145
69Autoimmune thrombocytopenia (HP:0001973)2.49411609
70Recurrent sinusitis (HP:0011108)2.47109075
71Pulmonary infiltrates (HP:0002113)2.46676623
72IgG deficiency (HP:0004315)2.45723278
73Epistaxis (HP:0000421)2.44359415
74Pulmonary embolism (HP:0002204)2.44116127
75Periodontitis (HP:0000704)2.43607725
76Encephalitis (HP:0002383)2.41186786
77Muscle fiber splitting (HP:0003555)2.39302280
78Easy fatigability (HP:0003388)2.36319707
79Petechiae (HP:0000967)2.35952935
80Urticaria (HP:0001025)2.35421048
81Pustule (HP:0200039)2.35123608
82Acute myeloid leukemia (HP:0004808)2.31955974
83IgA deficiency (HP:0002720)2.30750583
84Abnormality of skeletal muscle fiber size (HP:0012084)2.29765220
85Interstitial pulmonary disease (HP:0006530)2.29356135
86Increased IgE level (HP:0003212)2.28786054
87Subaortic stenosis (HP:0001682)2.26240782
88Abnormality of the left ventricular outflow tract (HP:0011103)2.26240782
89Acute hepatic failure (HP:0006554)2.25011842
90Increased IgM level (HP:0003496)2.24216247
91Keratoconjunctivitis (HP:0001096)2.23572953
92Hypoplasia of the thymus (HP:0000778)2.19587862
93Centrally nucleated skeletal muscle fibers (HP:0003687)2.18312801
94Hemoptysis (HP:0002105)2.17873545
95Difficulty running (HP:0009046)2.17269906
96Viral hepatitis (HP:0006562)2.17039307
97Hemiplegia (HP:0002301)2.15090787
98Amaurosis fugax (HP:0100576)2.14988147
99Gingival bleeding (HP:0000225)2.14357690
100Abnormal platelet function (HP:0011869)2.13999726
101Impaired platelet aggregation (HP:0003540)2.13999726
102Abnormality of the prostate (HP:0008775)2.13187836
103Toxemia of pregnancy (HP:0100603)2.12958000
104Gingivitis (HP:0000230)2.12477364
105Severe combined immunodeficiency (HP:0004430)2.09966939
106Volvulus (HP:0002580)2.09016175
107Vertigo (HP:0002321)2.08699232
108Recurrent pneumonia (HP:0006532)2.05805198
109Recurrent lower respiratory tract infections (HP:0002783)2.05025175
110Asymmetric septal hypertrophy (HP:0001670)2.04889739
111Hyporeflexia of lower limbs (HP:0002600)2.03518721
112Increased variability in muscle fiber diameter (HP:0003557)2.00711723
113Facial diplegia (HP:0001349)1.98288191
114Spondylolisthesis (HP:0003302)1.98257608
115Chronic sinusitis (HP:0011109)1.97345719
116Abnormality of the pleura (HP:0002103)1.97295115
117Vacuolated lymphocytes (HP:0001922)1.96645346
118Fatigue (HP:0012378)1.95460123
119Hypergammaglobulinemia (HP:0010702)1.93159947
120Sepsis (HP:0100806)1.92883616
121EMG: myopathic abnormalities (HP:0003458)1.91625436
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91238199
123Gastrointestinal infarctions (HP:0005244)1.90854347
124Amyloidosis (HP:0011034)1.90764767
125Lymphoma (HP:0002665)1.90050282
126Basal ganglia calcification (HP:0002135)1.88427089
127Combined immunodeficiency (HP:0005387)1.87004451
128Absent frontal sinuses (HP:0002688)1.85234823

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.40433057
2BMPR23.08588706
3TXK2.88171584
4BLK2.86676403
5PRPF4B2.73596698
6JAK32.67795117
7KIT2.52223374
8IRAK42.50361614
9TYK22.43316181
10MAP3K142.21120912
11ZAP702.16884585
12STK102.11978132
13ITK2.08146753
14IKBKB2.07450041
15BTK2.04339877
16TBK12.02708297
17TGFBR21.98247046
18TEC1.95372736
19TNK21.95327380
20DMPK1.92864946
21PIK3CG1.88951324
22CSF1R1.87119140
23IKBKE1.87048778
24SYK1.82154892
25EEF2K1.72369743
26OBSCN1.69845323
27FES1.69151668
28RIPK41.68117822
29JAK11.64814184
30MAP3K131.63770026
31FLT31.61868792
32FGFR31.56056566
33MAP2K31.50277112
34EPHB11.41215005
35TAOK31.35186454
36HCK1.34474213
37LCK1.32798674
38GRK61.28875358
39LRRK21.23395230
40CSK1.21262978
41TRPM71.13594427
42CHUK1.12244616
43TRIB31.08822125
44PKN21.06173577
45FGFR41.04740114
46LYN1.01765069
47ERN10.99844089
48CLK10.99440521
49MAPK70.99202448
50TTN0.94955521
51STK40.94287566
52NUAK10.92099735
53PIM10.88737040
54NLK0.87001807
55MAP3K10.86892455
56NEK90.85468019
57CAMK1D0.80971802
58STK240.80599590
59PTK60.78988821
60MATK0.78821514
61IRAK30.77916145
62KSR20.76901050
63RPS6KA40.76871347
64YES10.76273460
65CDK90.75509848
66NME20.75110060
67CAMK1G0.74441338
68EPHA30.74298217
69PRKCQ0.73511423
70FGR0.72089882
71MARK20.71359691
72IRAK10.68105653
73MAP3K30.66636705
74GRK70.66133435
75HIPK20.64735536
76JAK20.64696649
77PIK3CA0.62214581
78TGFBR10.59679715
79SIK20.59541297
80RET0.56320397
81RPS6KB20.54972206
82CAMKK10.54328100
83PDK10.54189175
84FYN0.53783860
85MARK30.53249151
86MST40.52676136
87PAK40.52641072
88MAP3K100.49211978
89SGK20.48896749
90CDK40.47690324
91MAP3K50.47465974
92RPS6KC10.46922799
93RPS6KL10.46922799
94MAPKAPK20.46914829
95CDK60.46496725
96BRSK20.45169784
97ALK0.44989890
98PDGFRB0.44953021
99PDPK10.44493008
100SGK30.43989699
101CAMKK20.43599744
102ADRBK20.41766197
103MAP3K60.41118571
104GSK3A0.40650415
105MOS0.40256436
106RAF10.39284904
107RPS6KA60.39267850
108TAOK10.38354353
109MAP3K70.37692191
110MAPK30.37493805
111PRKAA20.36008067
112PRKD20.35822395
113CDC42BPA0.35615060
114ABL10.35296525
115MAPK110.34490295
116MAPKAPK30.34374348
117ATR0.33064266
118MAP3K110.33027363
119CDK190.32906816
120TIE10.32839138
121FRK0.30485456
122MAPK120.30346437
123STK110.30137302
124TAOK20.29688412
125BRD40.29670375
126MAP3K80.29632342
127CDK120.29481621
128MAPK40.29340119
129SIK30.29318346
130PRKCH0.29090356
131WNK10.28900877
132IRAK20.28818223
133DYRK1B0.28705357

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.45667131
2B cell receptor signaling pathway_Homo sapiens_hsa046622.82568134
3Leishmaniasis_Homo sapiens_hsa051402.65042254
4Osteoclast differentiation_Homo sapiens_hsa043802.52074039
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.47371389
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.47040350
7Antigen processing and presentation_Homo sapiens_hsa046122.43901796
8Measles_Homo sapiens_hsa051622.36032003
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.34014815
10T cell receptor signaling pathway_Homo sapiens_hsa046602.20175838
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.14656196
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.10406127
13Jak-STAT signaling pathway_Homo sapiens_hsa046301.89604822
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.83624006
15Hematopoietic cell lineage_Homo sapiens_hsa046401.81231997
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.73762189
17Toxoplasmosis_Homo sapiens_hsa051451.68531670
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65111820
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.64284396
20Allograft rejection_Homo sapiens_hsa053301.62673096
21Herpes simplex infection_Homo sapiens_hsa051681.61859766
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.53821372
23Apoptosis_Homo sapiens_hsa042101.49867735
24Chemokine signaling pathway_Homo sapiens_hsa040621.47870372
25Viral myocarditis_Homo sapiens_hsa054161.47834052
26Platelet activation_Homo sapiens_hsa046111.46843745
27Graft-versus-host disease_Homo sapiens_hsa053321.46777933
28Acute myeloid leukemia_Homo sapiens_hsa052211.45176909
29Influenza A_Homo sapiens_hsa051641.40495663
30TNF signaling pathway_Homo sapiens_hsa046681.40402770
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39931421
32Tuberculosis_Homo sapiens_hsa051521.39258636
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.37569858
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37383622
35Hepatitis B_Homo sapiens_hsa051611.32032233
36Pertussis_Homo sapiens_hsa051331.25199481
37Legionellosis_Homo sapiens_hsa051341.23148797
38Shigellosis_Homo sapiens_hsa051311.22513529
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17780590
40Chronic myeloid leukemia_Homo sapiens_hsa052201.17073725
41Staphylococcus aureus infection_Homo sapiens_hsa051501.16259152
42Non-homologous end-joining_Homo sapiens_hsa034501.13887449
43Other glycan degradation_Homo sapiens_hsa005111.12102757
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06148476
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05711481
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.02743145
47Dorso-ventral axis formation_Homo sapiens_hsa043201.02195651
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01817602
49Malaria_Homo sapiens_hsa051441.01614854
50Autoimmune thyroid disease_Homo sapiens_hsa053200.94765414
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94494901
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92940259
53Viral carcinogenesis_Homo sapiens_hsa052030.92644675
54* Pancreatic cancer_Homo sapiens_hsa052120.89500714
55Asthma_Homo sapiens_hsa053100.89367283
56DNA replication_Homo sapiens_hsa030300.85655934
57Non-small cell lung cancer_Homo sapiens_hsa052230.84584876
58Hepatitis C_Homo sapiens_hsa051600.84393177
59Epstein-Barr virus infection_Homo sapiens_hsa051690.83231388
60Salmonella infection_Homo sapiens_hsa051320.82600977
61Prolactin signaling pathway_Homo sapiens_hsa049170.79538220
62Renal cell carcinoma_Homo sapiens_hsa052110.79427345
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79394365
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77595331
65Lysosome_Homo sapiens_hsa041420.75909225
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75884736
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.75502730
68African trypanosomiasis_Homo sapiens_hsa051430.74285197
69mTOR signaling pathway_Homo sapiens_hsa041500.73754503
70Base excision repair_Homo sapiens_hsa034100.73697449
71HTLV-I infection_Homo sapiens_hsa051660.73674156
72Small cell lung cancer_Homo sapiens_hsa052220.73585894
73Inositol phosphate metabolism_Homo sapiens_hsa005620.72359341
74Choline metabolism in cancer_Homo sapiens_hsa052310.69206357
75VEGF signaling pathway_Homo sapiens_hsa043700.67873825
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64517238
77Caffeine metabolism_Homo sapiens_hsa002320.62233797
78GnRH signaling pathway_Homo sapiens_hsa049120.61064832
79Long-term potentiation_Homo sapiens_hsa047200.59980610
80Insulin resistance_Homo sapiens_hsa049310.57238404
81Notch signaling pathway_Homo sapiens_hsa043300.57109629
82* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56969336
83Rheumatoid arthritis_Homo sapiens_hsa053230.56681218
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56259399
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56160191
86Glioma_Homo sapiens_hsa052140.55514963
87Endometrial cancer_Homo sapiens_hsa052130.55454855
88Renin secretion_Homo sapiens_hsa049240.54845671
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.54558279
90p53 signaling pathway_Homo sapiens_hsa041150.53555874
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.52362862
92Colorectal cancer_Homo sapiens_hsa052100.52331515
93Oxytocin signaling pathway_Homo sapiens_hsa049210.51610045
94HIF-1 signaling pathway_Homo sapiens_hsa040660.51304468
95MAPK signaling pathway_Homo sapiens_hsa040100.48593121
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47989519
97Mismatch repair_Homo sapiens_hsa034300.47915992
98FoxO signaling pathway_Homo sapiens_hsa040680.47758659
99MicroRNAs in cancer_Homo sapiens_hsa052060.47700675
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45718891
101Insulin signaling pathway_Homo sapiens_hsa049100.44909725
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.44023956
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43116918
104Phagosome_Homo sapiens_hsa041450.42573084
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.42259226
106Estrogen signaling pathway_Homo sapiens_hsa049150.41050149
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40757283
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40221679
109Focal adhesion_Homo sapiens_hsa045100.40007291
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39208466
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38232980
112Prostate cancer_Homo sapiens_hsa052150.37393326
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36339846
114Endocytosis_Homo sapiens_hsa041440.35900857
115Proteoglycans in cancer_Homo sapiens_hsa052050.35899309
116N-Glycan biosynthesis_Homo sapiens_hsa005100.35027964
117Amoebiasis_Homo sapiens_hsa051460.32705358
118Pathways in cancer_Homo sapiens_hsa052000.32153887
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31329834
120Type I diabetes mellitus_Homo sapiens_hsa049400.31025841
121Cell cycle_Homo sapiens_hsa041100.30109505
122Ribosome_Homo sapiens_hsa030100.29163700
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28604818

Most similar genes based on co-expression Upload to Enrichr

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