ARHGEF7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.79140613
2vocalization behavior (GO:0071625)4.70472600
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.61161056
4locomotory exploration behavior (GO:0035641)4.59681568
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.41588461
6heart field specification (GO:0003128)4.35547485
7secondary heart field specification (GO:0003139)4.35547485
8layer formation in cerebral cortex (GO:0021819)4.17909144
9ionotropic glutamate receptor signaling pathway (GO:0035235)4.13846874
10regulation of glutamate receptor signaling pathway (GO:1900449)4.12490120
11synaptic vesicle maturation (GO:0016188)4.01549810
12cardiac ventricle formation (GO:0003211)3.96053962
13protein localization to synapse (GO:0035418)3.95545585
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.91342600
15positive regulation of synapse maturation (GO:0090129)3.87299163
16cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.81352602
17synaptic vesicle exocytosis (GO:0016079)3.80576738
18glutamate receptor signaling pathway (GO:0007215)3.77520985
19cell communication by electrical coupling (GO:0010644)3.68479162
20presynaptic membrane assembly (GO:0097105)3.68272507
21regulation of synapse structural plasticity (GO:0051823)3.64182112
22glutamate secretion (GO:0014047)3.62695557
23exploration behavior (GO:0035640)3.61579216
24cardiac chamber formation (GO:0003207)3.59666866
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.58850287
26presynaptic membrane organization (GO:0097090)3.55883018
27dendrite morphogenesis (GO:0048813)3.51477423
28synaptic vesicle docking involved in exocytosis (GO:0016081)3.49186808
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.46659291
30neuron cell-cell adhesion (GO:0007158)3.45647545
31synaptic transmission, glutamatergic (GO:0035249)3.45259544
32synaptic vesicle endocytosis (GO:0048488)3.43646133
33cerebellar Purkinje cell differentiation (GO:0021702)3.40743358
34dendritic spine morphogenesis (GO:0060997)3.40478967
35neurotransmitter-gated ion channel clustering (GO:0072578)3.39351955
36specification of organ identity (GO:0010092)3.37113880
37establishment of nucleus localization (GO:0040023)3.36770454
38regulation of synapse maturation (GO:0090128)3.36664635
39cerebellar granule cell differentiation (GO:0021707)3.35922374
40neuron recognition (GO:0008038)3.34878988
41L-amino acid import (GO:0043092)3.29131110
42activation of protein kinase A activity (GO:0034199)3.28433414
43cell migration in hindbrain (GO:0021535)3.28375363
44G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.26775613
45regulation of synaptic vesicle exocytosis (GO:2000300)3.26011453
46cell migration involved in heart development (GO:0060973)3.21979789
47regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.19644675
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.17847610
49axonal fasciculation (GO:0007413)3.17183388
50amino acid import (GO:0043090)3.16732627
51central nervous system projection neuron axonogenesis (GO:0021952)3.15426555
52establishment of mitochondrion localization (GO:0051654)3.14537560
53neurotransmitter secretion (GO:0007269)3.13818940
54regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.12521247
55regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.12074449
56mechanosensory behavior (GO:0007638)3.11611509
57sodium ion export (GO:0071436)3.11537131
58endothelial cell differentiation (GO:0045446)3.08002502
59cardiac myofibril assembly (GO:0055003)3.07889250
60clathrin coat assembly (GO:0048268)3.07651737
61membrane depolarization during action potential (GO:0086010)3.05413198
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.03844779
63regulation of long-term neuronal synaptic plasticity (GO:0048169)3.02624077
64neuron-neuron synaptic transmission (GO:0007270)3.02577087
65regulation of postsynaptic membrane potential (GO:0060078)3.00245090
66response to pheromone (GO:0019236)2.99175769
67axon extension (GO:0048675)2.97764219
68regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.97273399
69gamma-aminobutyric acid transport (GO:0015812)2.96301284
70cell communication involved in cardiac conduction (GO:0086065)2.95866020
71plasma membrane repair (GO:0001778)2.92648522
72regulation of synaptic vesicle transport (GO:1902803)2.92311542
73positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90893405
74regulation of neuronal synaptic plasticity (GO:0048168)2.89775547
75regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88924576
76cellular potassium ion homeostasis (GO:0030007)2.88703016
77establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.86852473
78mitochondrion transport along microtubule (GO:0047497)2.86852473
79proline transport (GO:0015824)2.86316155
80positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.86205222
81regulation of vesicle fusion (GO:0031338)2.85961251
82postsynaptic membrane organization (GO:0001941)2.85181666
83neuromuscular process controlling balance (GO:0050885)2.84025192
84response to auditory stimulus (GO:0010996)2.83215553
85dendritic spine organization (GO:0097061)2.82346515
86G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.78994440
87regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.78884719
88regulation of NFAT protein import into nucleus (GO:0051532)2.78670022
89regulation of dendritic spine morphogenesis (GO:0061001)2.78454741
90gamma-aminobutyric acid signaling pathway (GO:0007214)2.78307175
91positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.76245040
92positive regulation of potassium ion transmembrane transport (GO:1901381)2.75486778
93membrane depolarization (GO:0051899)2.75445495
94axon ensheathment in central nervous system (GO:0032291)2.75027179
95central nervous system myelination (GO:0022010)2.75027179
96long-term memory (GO:0007616)2.74237904
97cell differentiation in hindbrain (GO:0021533)2.73673999
98regulation of membrane repolarization (GO:0060306)2.72020746
99positive regulation of endothelial cell apoptotic process (GO:2000353)2.69735243
100neuron projection extension (GO:1990138)2.69381008
101positive regulation of membrane potential (GO:0045838)2.67427441
102neuromuscular synaptic transmission (GO:0007274)2.66793924
103pyrimidine nucleobase catabolic process (GO:0006208)2.66722063
104regulation of cell communication by electrical coupling (GO:0010649)2.66134899
105neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.65279573
106negative regulation of inclusion body assembly (GO:0090084)2.64602413
107dendrite development (GO:0016358)2.63617401
108positive regulation of dendritic spine morphogenesis (GO:0061003)2.63571767
109cellular anion homeostasis (GO:0030002)2.63395580
110regulation of ARF protein signal transduction (GO:0032012)2.61812238
111neuronal action potential propagation (GO:0019227)2.61789785
112response to nerve growth factor (GO:1990089)2.61556900
113cellular response to nerve growth factor stimulus (GO:1990090)2.61556900
114regulation of sarcomere organization (GO:0060297)2.60814057
115dopamine receptor signaling pathway (GO:0007212)2.60737009
116regulation of synaptic transmission, glutamatergic (GO:0051966)2.60177365
117regulation of neurotransmitter secretion (GO:0046928)2.57815302
118positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.57802902
119auditory behavior (GO:0031223)2.57378162
120neuronal ion channel clustering (GO:0045161)2.57158730
121regulation of dendritic spine development (GO:0060998)2.56752374
122transmission of nerve impulse (GO:0019226)2.55903661
123regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.55177481
124regulation of synaptic plasticity (GO:0048167)2.54940402
125positive regulation of dendritic spine development (GO:0060999)2.54492551
126myofibril assembly (GO:0030239)2.53421049
127insulin-like growth factor receptor signaling pathway (GO:0048009)2.53087253
128regulation of calcium ion transmembrane transport (GO:1903169)2.52771917
129regulation of calcium ion transmembrane transporter activity (GO:1901019)2.52771917
130negative regulation of cytosolic calcium ion concentration (GO:0051481)2.52514739
131respiratory system process (GO:0003016)2.52455982
132long term synaptic depression (GO:0060292)2.52405547
133nucleus localization (GO:0051647)2.51691129
134regulation of voltage-gated calcium channel activity (GO:1901385)2.51573445
135nucleobase catabolic process (GO:0046113)2.51502664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.11752205
2GBX2_23144817_ChIP-Seq_PC3_Human3.13834449
3DROSHA_22980978_ChIP-Seq_HELA_Human2.72447908
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.70807814
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.63747586
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61372550
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53911949
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53911949
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.26360431
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25262380
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25103969
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.24145592
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22025676
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17205564
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16452884
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14552213
17REST_21632747_ChIP-Seq_MESCs_Mouse2.09902726
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09305421
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.08925671
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05924184
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.05133024
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.03291903
23* RARB_27405468_Chip-Seq_BRAIN_Mouse1.96975522
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.91602446
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75715831
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75561354
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74048262
28AR_21572438_ChIP-Seq_LNCaP_Human1.66935359
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64334340
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.61462822
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59232530
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.56935624
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54295557
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47637257
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47286227
36SMAD4_21799915_ChIP-Seq_A2780_Human1.46340454
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42108072
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40702268
39AHR_22903824_ChIP-Seq_MCF-7_Human1.40411270
40KDM2B_26808549_Chip-Seq_K562_Human1.38486749
41* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36054521
42WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35044667
43SOX2_21211035_ChIP-Seq_LN229_Gbm1.33360322
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32665283
45AR_19668381_ChIP-Seq_PC3_Human1.32554921
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.32465305
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31755241
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31372129
49RNF2_27304074_Chip-Seq_NSC_Mouse1.30219795
50KDM2B_26808549_Chip-Seq_JURKAT_Human1.29672255
51EP300_21415370_ChIP-Seq_HL-1_Mouse1.28809827
52* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28582087
53* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27339951
54KDM2B_26808549_Chip-Seq_DND41_Human1.27097062
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.25744999
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23056400
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.21629436
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21307231
59STAT3_23295773_ChIP-Seq_U87_Human1.20295806
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.20207680
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18728900
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18661849
63* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18311844
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17453571
65MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16859901
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15556261
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14587389
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14587389
69ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13838435
70AR_25329375_ChIP-Seq_VCAP_Human1.13641480
71* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12889532
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11926383
73NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11858185
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.11671915
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.10517239
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10273383
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10089351
78ZNF274_21170338_ChIP-Seq_K562_Hela1.09854698
79DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09836319
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09118390
81CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08715251
82SMAD3_21741376_ChIP-Seq_HESCs_Human1.08483623
83* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08027866
84SMAD4_21741376_ChIP-Seq_HESCs_Human1.07894622
85* TCF4_23295773_ChIP-Seq_U87_Human1.06975414
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06884892
87TP53_16413492_ChIP-PET_HCT116_Human1.06826861
88* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06774039
89TP53_20018659_ChIP-ChIP_R1E_Mouse1.05623967
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.04512414
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03744872
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03072657
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02605310
94RXR_22108803_ChIP-Seq_LS180_Human1.01374101
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01041141
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00482441
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99802058
98* P300_19829295_ChIP-Seq_ESCs_Human0.98216929
99P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97801258
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97305305
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97004440
102TCF7_22412390_ChIP-Seq_EML_Mouse0.96680189
103* SMAD3_21741376_ChIP-Seq_ESCs_Human0.96296771
104CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95672224
105ISL1_27105846_Chip-Seq_CPCs_Mouse0.95004252
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94885384
107DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94233862
108ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94210364
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94111743
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91147965
111CTCF_27219007_Chip-Seq_Bcells_Human0.90953313
112NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90581895
113RUNX2_22187159_ChIP-Seq_PCA_Human0.88998144
114RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88725655
115NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88562235
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86436911
117STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85889164
118* KDM2B_26808549_Chip-Seq_REH_Human0.84669897
119* TET1_21490601_ChIP-Seq_MESCs_Mouse0.80320617

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.03151597
2MP0000569_abnormal_digit_pigmentation4.08577889
3MP0003635_abnormal_synaptic_transmissio3.51097269
4MP0003880_abnormal_central_pattern3.06285181
5MP0009046_muscle_twitch2.92634219
6MP0002063_abnormal_learning/memory/cond2.80215697
7MP0009745_abnormal_behavioral_response2.70970534
8MP0000751_myopathy2.68951946
9MP0004270_analgesia2.54429218
10MP0002064_seizures2.43100823
11MP0005423_abnormal_somatic_nervous2.26937729
12MP0000778_abnormal_nervous_system2.25780470
13MP0002572_abnormal_emotion/affect_behav2.22251486
14MP0004215_abnormal_myocardial_fiber2.13536116
15MP0001968_abnormal_touch/_nociception2.07647457
16MP0004084_abnormal_cardiac_muscle2.07455825
17MP0002837_dystrophic_cardiac_calcinosis2.04172272
18MP0002735_abnormal_chemical_nociception2.02214986
19MP0009780_abnormal_chondrocyte_physiolo2.01777069
20MP0002734_abnormal_mechanical_nocicepti1.99860994
21MP0001440_abnormal_grooming_behavior1.96358748
22MP0004858_abnormal_nervous_system1.96249127
23MP0004145_abnormal_muscle_electrophysio1.94922081
24MP0001486_abnormal_startle_reflex1.93995156
25MP0004510_myositis1.92205654
26MP0002067_abnormal_sensory_capabilities1.81772619
27MP0002184_abnormal_innervation1.80264231
28MP0008569_lethality_at_weaning1.79562370
29MP0002272_abnormal_nervous_system1.67781843
30MP0003646_muscle_fatigue1.65234636
31MP0004811_abnormal_neuron_physiology1.65150442
32MP0003787_abnormal_imprinting1.64312923
33MP0002736_abnormal_nociception_after1.58149051
34MP0002733_abnormal_thermal_nociception1.55233534
35MP0001879_abnormal_lymphatic_vessel1.53190652
36MP0003137_abnormal_impulse_conducting1.49161574
37MP0004085_abnormal_heartbeat1.47792129
38MP0004924_abnormal_behavior1.44843979
39MP0005386_behavior/neurological_phenoty1.44843979
40MP0004484_altered_response_of1.44153855
41MP0002909_abnormal_adrenal_gland1.44026663
42MP0002557_abnormal_social/conspecific_i1.44009658
43MP0001970_abnormal_pain_threshold1.42369999
44MP0000955_abnormal_spinal_cord1.41737697
45MP0004885_abnormal_endolymph1.40501741
46MP0004036_abnormal_muscle_relaxation1.39846879
47MP0001348_abnormal_lacrimal_gland1.38548719
48MP0005666_abnormal_adipose_tissue1.38126935
49MP0005167_abnormal_blood-brain_barrier1.29257100
50MP0001501_abnormal_sleep_pattern1.28814519
51MP0002882_abnormal_neuron_morphology1.26900061
52MP0002972_abnormal_cardiac_muscle1.25644322
53MP0003690_abnormal_glial_cell1.23893681
54MP0008961_abnormal_basal_metabolism1.22490947
55MP0002638_abnormal_pupillary_reflex1.20094883
56MP0005623_abnormal_meninges_morphology1.17389455
57MP0004130_abnormal_muscle_cell1.16640253
58MP0002152_abnormal_brain_morphology1.15480076
59MP0003879_abnormal_hair_cell1.14920080
60MP0002066_abnormal_motor_capabilities/c1.14742878
61MP0004087_abnormal_muscle_fiber1.12513196
62MP0005620_abnormal_muscle_contractility1.12371585
63MP0005187_abnormal_penis_morphology1.10430126
64MP0003121_genomic_imprinting1.09926957
65MP0004233_abnormal_muscle_weight1.08223584
66MP0003122_maternal_imprinting1.07789139
67MP0001984_abnormal_olfaction1.06172304
68MP0008775_abnormal_heart_ventricle1.05882898
69MP0003123_paternal_imprinting1.05099426
70MP0001177_atelectasis1.04448663
71MP0006276_abnormal_autonomic_nervous1.04305617
72MP0001502_abnormal_circadian_rhythm1.02793734
73MP0002009_preneoplasia1.01832942
74MP0006138_congestive_heart_failure1.01616884
75MP0003329_amyloid_beta_deposits1.01006514
76MP0003172_abnormal_lysosome_physiology0.99762707
77MP0003633_abnormal_nervous_system0.99445095
78MP0002106_abnormal_muscle_physiology0.98529237
79MP0003828_pulmonary_edema0.96367269
80MP0005645_abnormal_hypothalamus_physiol0.94683706
81MP0005375_adipose_tissue_phenotype0.94643788
82MP0005646_abnormal_pituitary_gland0.94210552
83MP0000749_muscle_degeneration0.94092207
84MP0000920_abnormal_myelination0.92722527
85MP0003631_nervous_system_phenotype0.92539834
86MP0002822_catalepsy0.91744494
87MP0000631_abnormal_neuroendocrine_gland0.88506776
88MP0002234_abnormal_pharynx_morphology0.88155766
89MP0002752_abnormal_somatic_nervous0.88088750
90MP0003632_abnormal_nervous_system0.87848022
91MP0010630_abnormal_cardiac_muscle0.86633984
92MP0000015_abnormal_ear_pigmentation0.86058872
93MP0001188_hyperpigmentation0.86034124
94MP0001544_abnormal_cardiovascular_syste0.85335858
95MP0005385_cardiovascular_system_phenoty0.85335858
96MP0005670_abnormal_white_adipose0.84784758
97MP0002249_abnormal_larynx_morphology0.83097544
98MP0003948_abnormal_gas_homeostasis0.82695983
99MP0001943_abnormal_respiration0.82614462
100MP0003283_abnormal_digestive_organ0.81919437
101MP0001529_abnormal_vocalization0.81884075
102MP0005394_taste/olfaction_phenotype0.81451181
103MP0005499_abnormal_olfactory_system0.81451181
104MP0003861_abnormal_nervous_system0.81034134
105MP0001299_abnormal_eye_distance/0.80734749
106MP0005369_muscle_phenotype0.80716866
107MP0000537_abnormal_urethra_morphology0.80589962
108MP0002089_abnormal_postnatal_growth/wei0.80282537
109MP0005330_cardiomyopathy0.79987761
110MP0002081_perinatal_lethality0.79652825
111MP0010368_abnormal_lymphatic_system0.77463954
112MP0000759_abnormal_skeletal_muscle0.75911483
113MP0008877_abnormal_DNA_methylation0.75830865
114MP0000534_abnormal_ureter_morphology0.75566763
115MP0004142_abnormal_muscle_tone0.74717041
116MP0004742_abnormal_vestibular_system0.74552050
117MP0010768_mortality/aging0.71950828
118MP0002332_abnormal_exercise_endurance0.69984989
119MP0002069_abnormal_eating/drinking_beha0.69561733
120MP0003634_abnormal_glial_cell0.68302875
121MP0003045_fibrosis0.68129611
122MP0003303_peritoneal_inflammation0.67857423
123MP0009278_abnormal_bone_marrow0.67661400
124MP0010769_abnormal_survival0.67146219
125MP0005409_darkened_coat_color0.66978683
126MP0000747_muscle_weakness0.65449832
127MP0003385_abnormal_body_wall0.65247549
128MP0009115_abnormal_fat_cell0.65072471
129MP0010770_preweaning_lethality0.64900175
130MP0002082_postnatal_lethality0.64900175
131MP0003091_abnormal_cell_migration0.63244896
132MP0001963_abnormal_hearing_physiology0.63117483

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.49791132
2Focal seizures (HP:0007359)4.11724781
3Progressive cerebellar ataxia (HP:0002073)4.10223723
4Neonatal hypoglycemia (HP:0001998)3.88380058
5Visual hallucinations (HP:0002367)3.75834329
6Febrile seizures (HP:0002373)3.73225303
7Genetic anticipation (HP:0003743)3.66517130
8Myokymia (HP:0002411)3.64293450
9Chin dimple (HP:0010751)3.47792512
10Sudden death (HP:0001699)3.43333558
11Epileptic encephalopathy (HP:0200134)3.40795506
12Dysmetric saccades (HP:0000641)3.27491906
13Autoimmune thrombocytopenia (HP:0001973)3.11894118
14Abnormality of the fingertips (HP:0001211)3.11070833
15Action tremor (HP:0002345)3.06882353
16Broad-based gait (HP:0002136)3.02718242
17Atrial fibrillation (HP:0005110)2.99159057
18Gaze-evoked nystagmus (HP:0000640)2.96508289
19Atonic seizures (HP:0010819)2.91847732
20Lower limb amyotrophy (HP:0007210)2.91674388
21Primary atrial arrhythmia (HP:0001692)2.90150917
22Anterior segment dysgenesis (HP:0007700)2.83239693
23Prolonged QT interval (HP:0001657)2.82922494
24Excessive salivation (HP:0003781)2.76749801
25Drooling (HP:0002307)2.76749801
26Bundle branch block (HP:0011710)2.75819742
27Spastic gait (HP:0002064)2.75700134
28Hypoplasia of the iris (HP:0007676)2.71398428
29Supranuclear gaze palsy (HP:0000605)2.70285660
30Hemiplegia (HP:0002301)2.68620870
31Supraventricular tachycardia (HP:0004755)2.67257332
32Ventricular fibrillation (HP:0001663)2.66837479
33Urinary bladder sphincter dysfunction (HP:0002839)2.66354476
34Supraventricular arrhythmia (HP:0005115)2.66206712
35Mutism (HP:0002300)2.59986961
36Abnormality of the lower motor neuron (HP:0002366)2.55094027
37Syncope (HP:0001279)2.53692912
38Generalized tonic-clonic seizures (HP:0002069)2.52094680
39Abnormality of the columella (HP:0009929)2.46157461
40Dysdiadochokinesis (HP:0002075)2.45405578
41Peripheral hypomyelination (HP:0007182)2.41897672
42Papilledema (HP:0001085)2.41875526
43Poor eye contact (HP:0000817)2.41717761
44Hemiparesis (HP:0001269)2.41388978
45Exercise-induced myalgia (HP:0003738)2.40779711
46Impaired vibration sensation in the lower limbs (HP:0002166)2.40153463
47Abnormal EKG (HP:0003115)2.39684117
48Absence seizures (HP:0002121)2.38494202
49Abnormality of binocular vision (HP:0011514)2.38035845
50Diplopia (HP:0000651)2.38035845
51Impaired social interactions (HP:0000735)2.36865940
52Abnormal social behavior (HP:0012433)2.36865940
53Pointed chin (HP:0000307)2.36187991
54Impaired smooth pursuit (HP:0007772)2.35917838
55Neurofibrillary tangles (HP:0002185)2.34244840
56Elfin facies (HP:0004428)2.31626848
57Inappropriate behavior (HP:0000719)2.30459457
58Absent speech (HP:0001344)2.30308535
59Dialeptic seizures (HP:0011146)2.30173573
60Hyperacusis (HP:0010780)2.29274663
61Truncal ataxia (HP:0002078)2.21745939
62Abnormality of ocular smooth pursuit (HP:0000617)2.19762888
63Dysmetria (HP:0001310)2.19334299
64Distal lower limb amyotrophy (HP:0008944)2.18229060
65Long eyelashes (HP:0000527)2.17782009
66Sleep apnea (HP:0010535)2.17153923
67Annular pancreas (HP:0001734)2.16628446
68Lip pit (HP:0100267)2.15683334
69Hepatoblastoma (HP:0002884)2.15398240
70Sparse lateral eyebrow (HP:0005338)2.15330375
71Scanning speech (HP:0002168)2.15171331
72Obstructive sleep apnea (HP:0002870)2.11187807
73Myotonia (HP:0002486)2.11010677
74Hyperventilation (HP:0002883)2.10889043
75Turricephaly (HP:0000262)2.10509634
76Postural instability (HP:0002172)2.10489737
77Abnormal eating behavior (HP:0100738)2.09220551
78Depression (HP:0000716)2.08128219
79Urinary urgency (HP:0000012)2.07747783
80Ankle clonus (HP:0011448)2.07427549
81Long palpebral fissure (HP:0000637)2.06774990
82Overgrowth (HP:0001548)2.03630552
83Depressed nasal tip (HP:0000437)2.03365558
84Abnormality of the calf musculature (HP:0001430)2.02479905
85Abnormal delayed hypersensitivity skin test (HP:0002963)2.01242096
86Stereotypic behavior (HP:0000733)2.01197808
87Insomnia (HP:0100785)2.01038942
88Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.98425398
89Shallow orbits (HP:0000586)1.96967932
90Premature skin wrinkling (HP:0100678)1.96887277
91Deeply set eye (HP:0000490)1.96526507
92Limb dystonia (HP:0002451)1.96081510
93Ventricular arrhythmia (HP:0004308)1.95837231
94Pachygyria (HP:0001302)1.95182414
95Megalocornea (HP:0000485)1.94495554
96Autoimmune hemolytic anemia (HP:0001890)1.94365561
97Abnormality of the left ventricular outflow tract (HP:0011103)1.93580871
98Subaortic stenosis (HP:0001682)1.93580871
99Amblyopia (HP:0000646)1.93496567
100Difficulty running (HP:0009046)1.93153413
101Narrow palate (HP:0000189)1.91211243
102Enlarged epiphyses (HP:0010580)1.90912912
103Lower limb asymmetry (HP:0100559)1.88351846
104Lymphangioma (HP:0100764)1.87625471
105Fetal akinesia sequence (HP:0001989)1.87117537
106Birth length less than 3rd percentile (HP:0003561)1.86557867
107Agammaglobulinemia (HP:0004432)1.85655254
108Precocious puberty (HP:0000826)1.84555022
109Mask-like facies (HP:0000298)1.84166793
110Exotropia (HP:0000577)1.83342982
111Lower limb muscle weakness (HP:0007340)1.82899940
112Hammertoe (HP:0001765)1.82608654
113Thickened helices (HP:0000391)1.81467452
114Cerebral inclusion bodies (HP:0100314)1.81290566
115Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81011108
116Ventricular tachycardia (HP:0004756)1.80721468
117Heterotopia (HP:0002282)1.80563486
118Incomplete penetrance (HP:0003829)1.79776244
119Renovascular hypertension (HP:0100817)1.78275193
120Aqueductal stenosis (HP:0002410)1.77125921
121Ulnar claw (HP:0001178)1.76741289
122Epileptiform EEG discharges (HP:0011182)1.75909074
123Torticollis (HP:0000473)1.74902868
124Short 4th metacarpal (HP:0010044)1.74818224
125Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.74818224
126Abnormality of the corticospinal tract (HP:0002492)1.74207422
127Vertebral arch anomaly (HP:0008438)1.73798084
128Open mouth (HP:0000194)1.73157221
129Protruding tongue (HP:0010808)1.73026460
130Status epilepticus (HP:0002133)1.72941778
131Deep palmar crease (HP:0006191)1.72669473
132Macroorchidism (HP:0000053)1.70615162
133Heart block (HP:0012722)1.70482545
134Increased IgM level (HP:0003496)1.70481229
135Polyphagia (HP:0002591)1.69475787
136Hyporeflexia of lower limbs (HP:0002600)1.68722340
137Sacral dimple (HP:0000960)1.68682185
138Abnormality of the anterior chamber (HP:0000593)1.68642710
139Bronchomalacia (HP:0002780)1.68173405
140Hypoplasia of the brainstem (HP:0002365)1.68138605
141Aplasia/Hypoplasia of the brainstem (HP:0007362)1.68138605
142Anxiety (HP:0000739)1.67912911
143Hypsarrhythmia (HP:0002521)1.67813469
144Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.67520020
145Neoplasm of the heart (HP:0100544)1.67512579
146Amyotrophic lateral sclerosis (HP:0007354)1.67487187
147Megalencephaly (HP:0001355)1.67248833
148EEG with generalized epileptiform discharges (HP:0011198)1.66899752
149Exercise-induced muscle cramps (HP:0003710)1.66822139

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.37822453
2NTRK33.06656239
3MAP3K92.72240409
4SIK22.61318536
5MAP3K42.53518731
6DAPK22.43401052
7EPHA42.19413950
8MAP2K72.19299314
9TLK12.18861836
10PAK62.01572317
11MINK12.00321479
12CDK191.99795729
13NTRK21.98170105
14RIPK11.98073225
15PHKG11.89576599
16PHKG21.89576599
17MAPK131.71724983
18CAMKK11.59631941
19CAMK1G1.58798153
20TNIK1.51284431
21DMPK1.50830444
22STK381.45491214
23SGK21.45221557
24LATS21.38270383
25MAP2K41.37719389
26PLK21.35918646
27CASK1.30707771
28TTN1.26024665
29KSR11.25915080
30MARK21.24708448
31CDK51.23596461
32SGK31.21093711
33PRPF4B1.17947712
34TIE11.15994601
35SGK2231.14462020
36SGK4941.14462020
37PRKD31.12939454
38PKN21.10168651
39PDGFRB1.09829210
40ICK1.07364583
41CAMKK21.03715050
42TRIB31.01905325
43FES1.00227839
44CAMK40.99355027
45DAPK10.99113615
46MAPK150.99090586
47LMTK20.97077628
48TAOK10.96924417
49CDC42BPA0.96672743
50RIPK40.96213998
51SGK10.94597829
52PTK2B0.92807980
53PRKCH0.92634397
54MAPK120.91917026
55STK110.90954406
56CAMK10.89815673
57KSR20.88649941
58CAMK1D0.86087255
59OXSR10.85223179
60MAP3K100.85038433
61RPS6KA20.83530626
62ERBB30.83267070
63TYRO30.79063468
64CAMK2A0.76178334
65PKN10.75590856
66EPHB20.74950845
67PTK60.74707065
68BRD40.72485785
69PAK30.71575457
70EPHA30.70579406
71RET0.69924143
72MAP3K60.67932839
73DYRK1A0.67549633
74PNCK0.66986878
75ALK0.66867427
76UHMK10.66188055
77CSNK1G20.64935956
78EEF2K0.64916611
79* PRKCG0.64769471
80FGFR20.63987467
81WNK10.61083807
82MAP3K130.60749973
83MAPK70.60343792
84MAP3K70.60329233
85SIK30.59358982
86TAOK20.59100871
87GRK50.58975784
88TNK20.55750011
89ROCK10.55520631
90DYRK1B0.55491994
91RPS6KA30.55376369
92PRKCE0.55252078
93MTOR0.54701682
94PDGFRA0.53761355
95PRKAA10.52466268
96FYN0.51221779
97CDK140.50650275
98CDK120.50564716
99NTRK10.49989813
100AKT30.49677600
101PRKCZ0.49312930
102OBSCN0.49137609
103FGFR30.48567301
104CAMK2B0.46032023
105MAPK80.45569493
106PRKD10.45339154
107CDK150.42508524
108MAPK100.42082190
109CDK180.42006591
110GSK3B0.41427702
111MOS0.40373164
112PIK3CA0.40197672
113PDK10.39746849
114DYRK20.39338018
115ERBB20.39280022
116MAPK40.39189051
117* PRKG10.38897377
118MAP2K60.38514719
119CDK11A0.36191057
120MAPK90.35986587
121PINK10.35794400
122PDPK10.35671759
123DDR20.35664649
124SRC0.35434058

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.99131611
2Synaptic vesicle cycle_Homo sapiens_hsa047212.36706091
3Circadian entrainment_Homo sapiens_hsa047132.34907794
4Glutamatergic synapse_Homo sapiens_hsa047242.22158768
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19758478
6Morphine addiction_Homo sapiens_hsa050322.11882457
7GABAergic synapse_Homo sapiens_hsa047272.04209355
8Long-term potentiation_Homo sapiens_hsa047202.01565683
9Olfactory transduction_Homo sapiens_hsa047401.97371951
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77479960
11Cholinergic synapse_Homo sapiens_hsa047251.74143710
12Dilated cardiomyopathy_Homo sapiens_hsa054141.73800970
13Salivary secretion_Homo sapiens_hsa049701.68363416
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67868542
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67192307
16Dopaminergic synapse_Homo sapiens_hsa047281.64471043
17Oxytocin signaling pathway_Homo sapiens_hsa049211.60710408
18Amphetamine addiction_Homo sapiens_hsa050311.59976031
19Type II diabetes mellitus_Homo sapiens_hsa049301.58284235
20Gastric acid secretion_Homo sapiens_hsa049711.52133503
21Renin secretion_Homo sapiens_hsa049241.50516388
22Insulin secretion_Homo sapiens_hsa049111.46239811
23Taste transduction_Homo sapiens_hsa047421.45505230
24Long-term depression_Homo sapiens_hsa047301.44645670
25Axon guidance_Homo sapiens_hsa043601.42704739
26Calcium signaling pathway_Homo sapiens_hsa040201.42124987
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.35648700
28GnRH signaling pathway_Homo sapiens_hsa049121.31664761
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29487523
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26369337
31cAMP signaling pathway_Homo sapiens_hsa040241.26310305
32Gap junction_Homo sapiens_hsa045401.24636262
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23116100
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.22214108
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.20740256
36Estrogen signaling pathway_Homo sapiens_hsa049151.18620044
37Notch signaling pathway_Homo sapiens_hsa043301.18572852
38Serotonergic synapse_Homo sapiens_hsa047261.17973609
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14153171
40Glioma_Homo sapiens_hsa052141.13417374
41Cardiac muscle contraction_Homo sapiens_hsa042601.11984193
42B cell receptor signaling pathway_Homo sapiens_hsa046621.11929482
43Cocaine addiction_Homo sapiens_hsa050301.08246699
44Prolactin signaling pathway_Homo sapiens_hsa049171.08218400
45Prion diseases_Homo sapiens_hsa050201.06014042
46Dorso-ventral axis formation_Homo sapiens_hsa043201.05519658
47African trypanosomiasis_Homo sapiens_hsa051431.01578987
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01282213
49ErbB signaling pathway_Homo sapiens_hsa040121.01007203
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95530544
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.95297253
52Melanogenesis_Homo sapiens_hsa049160.92535892
53Collecting duct acid secretion_Homo sapiens_hsa049660.92308731
54Endometrial cancer_Homo sapiens_hsa052130.88044872
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87805773
56FoxO signaling pathway_Homo sapiens_hsa040680.87358883
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86564125
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.85625688
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.84748752
60mTOR signaling pathway_Homo sapiens_hsa041500.84425444
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84200608
62Acute myeloid leukemia_Homo sapiens_hsa052210.84140164
63Choline metabolism in cancer_Homo sapiens_hsa052310.81896903
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81106430
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80283397
66Vitamin B6 metabolism_Homo sapiens_hsa007500.79454405
67MAPK signaling pathway_Homo sapiens_hsa040100.78157209
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76707385
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75654105
70Pancreatic cancer_Homo sapiens_hsa052120.75210080
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74879929
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73303613
73Rap1 signaling pathway_Homo sapiens_hsa040150.72061019
74Renal cell carcinoma_Homo sapiens_hsa052110.70695908
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70198190
76VEGF signaling pathway_Homo sapiens_hsa043700.69360335
77Glucagon signaling pathway_Homo sapiens_hsa049220.69159689
78Inositol phosphate metabolism_Homo sapiens_hsa005620.68744065
79Colorectal cancer_Homo sapiens_hsa052100.68030594
80Prostate cancer_Homo sapiens_hsa052150.67772826
81Focal adhesion_Homo sapiens_hsa045100.66966993
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66721320
83Viral myocarditis_Homo sapiens_hsa054160.66530043
84Insulin signaling pathway_Homo sapiens_hsa049100.65663936
85Adherens junction_Homo sapiens_hsa045200.64298326
86MicroRNAs in cancer_Homo sapiens_hsa052060.63491825
87Ovarian steroidogenesis_Homo sapiens_hsa049130.60418378
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60400161
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60316901
90Fatty acid biosynthesis_Homo sapiens_hsa000610.60243493
91Pancreatic secretion_Homo sapiens_hsa049720.59773695
92Ras signaling pathway_Homo sapiens_hsa040140.58199490
93Oocyte meiosis_Homo sapiens_hsa041140.57929557
94T cell receptor signaling pathway_Homo sapiens_hsa046600.57819297
95Platelet activation_Homo sapiens_hsa046110.57273558
96Proteoglycans in cancer_Homo sapiens_hsa052050.56302174
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55384716
98Thyroid hormone synthesis_Homo sapiens_hsa049180.55286965
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54792171
100Non-small cell lung cancer_Homo sapiens_hsa052230.53963912
101* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53181499
102Chronic myeloid leukemia_Homo sapiens_hsa052200.51983592
103Hepatitis B_Homo sapiens_hsa051610.51953667
104Chemokine signaling pathway_Homo sapiens_hsa040620.51071362
105Insulin resistance_Homo sapiens_hsa049310.49991891
106Bile secretion_Homo sapiens_hsa049760.49732919
107Lysine degradation_Homo sapiens_hsa003100.49698946
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49526975
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.49382650
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48368346
111Melanoma_Homo sapiens_hsa052180.48332536
112Circadian rhythm_Homo sapiens_hsa047100.47981545
113Wnt signaling pathway_Homo sapiens_hsa043100.47467889
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47184006
115HIF-1 signaling pathway_Homo sapiens_hsa040660.47129496
116AMPK signaling pathway_Homo sapiens_hsa041520.46386650
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46251027
118Endocytosis_Homo sapiens_hsa041440.45892157
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45342006
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.44792820
121Amoebiasis_Homo sapiens_hsa051460.44612762

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