ARID1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes an AT-rich DNA interacting domain-containing protein. The encoded protein is a component of the SWI/SNF chromatin remodeling complex and may play a role in cell-cycle activation. The protein encoded by this locus is similar to AT-rich interactive domain-containing protein 1A. These two proteins function as alternative, mutually exclusive ARID-subunits of the SWI/SNF complex. The associated complexes play opposing roles. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interkinetic nuclear migration (GO:0022027)4.30438063
2regulation of pigment cell differentiation (GO:0050932)3.96902089
3monoubiquitinated protein deubiquitination (GO:0035520)3.90509928
4positive regulation of gamma-delta T cell activation (GO:0046645)3.88363171
5positive regulation of developmental pigmentation (GO:0048087)3.85081568
6definitive hemopoiesis (GO:0060216)3.66109027
7histone H3-K4 trimethylation (GO:0080182)3.63090253
8cardiac ventricle formation (GO:0003211)3.56192782
9establishment of protein localization to Golgi (GO:0072600)3.43395112
10histone H3-K9 methylation (GO:0051567)3.42989890
11negative regulation of erythrocyte differentiation (GO:0045647)3.41529731
12behavioral response to nicotine (GO:0035095)3.41184785
13phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.39954835
14peptidyl-lysine methylation (GO:0018022)3.27660579
15megakaryocyte development (GO:0035855)3.18454107
16cardiac chamber formation (GO:0003207)3.17813809
17nucleus localization (GO:0051647)3.14936289
18kidney morphogenesis (GO:0060993)3.12592926
19positive regulation of B cell differentiation (GO:0045579)3.11840369
20protein-DNA complex disassembly (GO:0032986)3.11785750
21nucleosome disassembly (GO:0006337)3.11785750
22negative regulation of cell killing (GO:0031342)3.10541312
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.10541312
24positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.09661426
25regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.09661426
26B cell receptor signaling pathway (GO:0050853)3.02552252
27histone lysine methylation (GO:0034968)2.98669918
28histone H3-K9 modification (GO:0061647)2.95944084
29microtubule anchoring (GO:0034453)2.95424301
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.92413809
31phospholipid translocation (GO:0045332)2.89336691
32lipid translocation (GO:0034204)2.89336691
33cytoplasmic mRNA processing body assembly (GO:0033962)2.85703211
34embryonic hemopoiesis (GO:0035162)2.84232963
35regulation of establishment of cell polarity (GO:2000114)2.79358084
36cerebellar Purkinje cell differentiation (GO:0021702)2.79188820
37regulation of hippo signaling (GO:0035330)2.76680703
38regulation of gamma-delta T cell differentiation (GO:0045586)2.74746905
39negative regulation of phagocytosis (GO:0050765)2.73904381
40retrograde transport, vesicle recycling within Golgi (GO:0000301)2.72845190
41negative regulation of cytosolic calcium ion concentration (GO:0051481)2.72653667
42pyrimidine nucleobase catabolic process (GO:0006208)2.69830394
43protein K11-linked deubiquitination (GO:0035871)2.69087596
44regulation of gamma-delta T cell activation (GO:0046643)2.66903724
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.64244241
46cardiovascular system development (GO:0072358)2.63724826
47protein targeting to Golgi (GO:0000042)2.63388481
48limb bud formation (GO:0060174)2.62037660
49negative regulation of T-helper cell differentiation (GO:0045623)2.60780148
50negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.60780148
51sympathetic nervous system development (GO:0048485)2.60646766
52protein K48-linked deubiquitination (GO:0071108)2.59873572
53T cell homeostasis (GO:0043029)2.59277150
54central nervous system projection neuron axonogenesis (GO:0021952)2.59097953
55regulation of B cell differentiation (GO:0045577)2.58782573
56cellular response to ethanol (GO:0071361)2.58722514
57central nervous system neuron axonogenesis (GO:0021955)2.58124449
58fucose catabolic process (GO:0019317)2.56708446
59L-fucose metabolic process (GO:0042354)2.56708446
60L-fucose catabolic process (GO:0042355)2.56708446
61spinal cord motor neuron differentiation (GO:0021522)2.55419232
62regulation of mRNA catabolic process (GO:0061013)2.54318415
63snRNA transcription (GO:0009301)2.54043920
64regulation of telomere maintenance (GO:0032204)2.52388836
65presynaptic membrane organization (GO:0097090)2.51978432
66establishment of nucleus localization (GO:0040023)2.51113509
67pericardium development (GO:0060039)2.50617462
68indolalkylamine metabolic process (GO:0006586)2.50336040
69cAMP catabolic process (GO:0006198)2.50070895
70Golgi to endosome transport (GO:0006895)2.48927346
71spinal cord development (GO:0021510)2.47722761
72secondary heart field specification (GO:0003139)2.45897675
73heart field specification (GO:0003128)2.45897675
74myeloid dendritic cell activation (GO:0001773)2.45767457
75T cell selection (GO:0045058)2.45256379
76retina layer formation (GO:0010842)2.44808576
77histone H3-K4 methylation (GO:0051568)2.44781526
78regulation of establishment or maintenance of cell polarity (GO:0032878)2.42969552
79cyclic nucleotide catabolic process (GO:0009214)2.42336090
80indole-containing compound catabolic process (GO:0042436)2.41971970
81indolalkylamine catabolic process (GO:0046218)2.41971970
82tryptophan catabolic process (GO:0006569)2.41971970
83regulation of erythrocyte differentiation (GO:0045646)2.41062259
84regulation of nuclear cell cycle DNA replication (GO:0033262)2.40938390
85regulation of gene silencing by miRNA (GO:0060964)2.40480880
86regulation of gene silencing by RNA (GO:0060966)2.40480880
87regulation of posttranscriptional gene silencing (GO:0060147)2.40480880
88renal tubule morphogenesis (GO:0061333)2.39846134
89B cell homeostasis (GO:0001782)2.39557827
90regulation of developmental pigmentation (GO:0048070)2.37886093
91regulation of B cell receptor signaling pathway (GO:0050855)2.37296857
92response to muramyl dipeptide (GO:0032495)2.36605009
93mature B cell differentiation (GO:0002335)2.36278579
94nephron tubule morphogenesis (GO:0072078)2.35291053
95nephron epithelium morphogenesis (GO:0072088)2.35291053
96regulation of sarcomere organization (GO:0060297)2.34550963
97cellular response to sterol (GO:0036315)2.33289016
98hindbrain development (GO:0030902)2.31130936
99histone methylation (GO:0016571)2.29950251
100negative regulation of DNA-dependent DNA replication (GO:2000104)2.29702935
101response to interleukin-15 (GO:0070672)2.29497478
102regulation of ARF protein signal transduction (GO:0032012)2.29239479
103response to pheromone (GO:0019236)2.29001437
104behavioral response to ethanol (GO:0048149)2.28926337
105dentate gyrus development (GO:0021542)2.28019314
106corticosteroid receptor signaling pathway (GO:0031958)2.27943389
107neutrophil activation (GO:0042119)2.27526114
108mast cell degranulation (GO:0043303)2.26984074
109mast cell activation involved in immune response (GO:0002279)2.26984074
110limb development (GO:0060173)2.26074715
111appendage development (GO:0048736)2.26074715
112neuronal stem cell maintenance (GO:0097150)2.25911110
113cell proliferation in forebrain (GO:0021846)2.25867241
114neuron maturation (GO:0042551)2.24472524
115prenylation (GO:0097354)2.23249954
116protein prenylation (GO:0018342)2.23249954
117histone H3-K36 demethylation (GO:0070544)2.22904909
118neural tube formation (GO:0001841)2.22727725
119somite development (GO:0061053)2.21572168
120growth hormone receptor signaling pathway (GO:0060396)2.21348982
121tryptophan metabolic process (GO:0006568)2.21139402
122germinal center formation (GO:0002467)2.21013573
123negative thymic T cell selection (GO:0045060)2.20918895
124protein K63-linked deubiquitination (GO:0070536)2.20798806
125membrane depolarization during action potential (GO:0086010)2.20537260
126mast cell activation (GO:0045576)2.20343036
127replication fork processing (GO:0031297)2.20305537
128negative regulation of translation, ncRNA-mediated (GO:0040033)2.20250524
129regulation of translation, ncRNA-mediated (GO:0045974)2.20250524
130negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.20250524
131nucleobase catabolic process (GO:0046113)2.19753242
132lymphocyte homeostasis (GO:0002260)2.19604682
133regulation of platelet aggregation (GO:0090330)2.19057357
134activated T cell proliferation (GO:0050798)2.18728179
135cilium or flagellum-dependent cell motility (GO:0001539)2.18476058
136lymphoid progenitor cell differentiation (GO:0002320)2.18298781
137regulation of NFAT protein import into nucleus (GO:0051532)2.18169249
138negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.17900607
139positive regulation of granulocyte differentiation (GO:0030854)2.17884118
140positive regulation of histone deacetylation (GO:0031065)2.17819895
141regulation of interleukin-12 biosynthetic process (GO:0045075)2.17461673
142cellular response to thyroid hormone stimulus (GO:0097067)2.16255280
143positive T cell selection (GO:0043368)2.16207840
144positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.16108661
145peptidyl-lysine trimethylation (GO:0018023)2.15777595
146germ cell migration (GO:0008354)2.14524103
147negative T cell selection (GO:0043383)2.13719904
148regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.13678900
149positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.13678900
150myeloid dendritic cell differentiation (GO:0043011)2.12947710
151presynaptic membrane assembly (GO:0097105)2.10508694
152CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.10429760
153NIK/NF-kappaB signaling (GO:0038061)2.10179929
154hepatocyte apoptotic process (GO:0097284)2.09859035
155positive regulation of mRNA catabolic process (GO:0061014)2.09597907
156natural killer cell differentiation (GO:0001779)2.08365933
157G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.07636263
158regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.07231589
159positive thymic T cell selection (GO:0045059)2.06396652
160regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.06109093
161JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.05973239
162positive regulation of CREB transcription factor activity (GO:0032793)2.05448120
163T cell lineage commitment (GO:0002360)2.05406874
164thymic T cell selection (GO:0045061)2.04582163
165granulocyte activation (GO:0036230)2.04365630
166cellular response to zinc ion (GO:0071294)2.03809134
167B cell differentiation (GO:0030183)2.03675325
168regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.03398319
169monocyte differentiation (GO:0030224)2.02940113
170mucosal-associated lymphoid tissue development (GO:0048537)2.02868135
171Peyers patch development (GO:0048541)2.02868135
172dendritic cell chemotaxis (GO:0002407)2.02093379
173antigen processing and presentation of endogenous antigen (GO:0019883)2.01789374
174regulation of DNA endoreduplication (GO:0032875)2.01354570
175CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.00624959
176mitotic sister chromatid cohesion (GO:0007064)2.00435093
177positive regulation of response to oxidative stress (GO:1902884)2.00289647
178positive regulation of cellular response to oxidative stress (GO:1900409)2.00289647
179negative regulation of granulocyte differentiation (GO:0030853)1.99252908
180glucocorticoid receptor signaling pathway (GO:0042921)1.98387355
181specification of organ identity (GO:0010092)1.96984570
182regulation of histone H3-K4 methylation (GO:0051569)1.95497591
183angiogenesis involved in wound healing (GO:0060055)1.93844139
184lymph node development (GO:0048535)1.93685390
185interferon-gamma-mediated signaling pathway (GO:0060333)1.93318832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.82347265
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.38520596
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.79975928
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.78295667
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.76698313
6EZH2_22144423_ChIP-Seq_EOC_Human2.71567870
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69770194
8SCL_19346495_ChIP-Seq_HPC-7_Human2.50184235
9ZNF274_21170338_ChIP-Seq_K562_Hela2.41528886
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40757491
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.29035291
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.28832026
13FUS_26573619_Chip-Seq_HEK293_Human2.18288416
14RUNX_20019798_ChIP-Seq_JUKART_Human2.18282656
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.12828114
16VDR_22108803_ChIP-Seq_LS180_Human2.12775757
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03792437
18EWS_26573619_Chip-Seq_HEK293_Human2.01063102
19* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00966289
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00243476
21GBX2_23144817_ChIP-Seq_PC3_Human1.97929826
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.97887175
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.94817998
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.94493533
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.92557354
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92257267
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88029721
28* P300_19829295_ChIP-Seq_ESCs_Human1.87946040
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87832083
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.86887891
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83499862
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82566683
33* STAT3_23295773_ChIP-Seq_U87_Human1.82179420
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.81933199
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.79782420
36TCF7_22412390_ChIP-Seq_EML_Mouse1.75578356
37IGF1R_20145208_ChIP-Seq_DFB_Human1.69636883
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66397974
39* TCF4_23295773_ChIP-Seq_U87_Human1.66158310
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64078782
41ER_23166858_ChIP-Seq_MCF-7_Human1.63897716
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62341278
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61304037
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60214247
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59309929
46MYC_22102868_ChIP-Seq_BL_Human1.55151178
47VDR_21846776_ChIP-Seq_THP-1_Human1.54386556
48* SMAD3_21741376_ChIP-Seq_EPCs_Human1.53658634
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53075405
50* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.51451275
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.50358562
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49303605
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49040020
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49040020
55AHR_22903824_ChIP-Seq_MCF-7_Human1.47070965
56AR_21572438_ChIP-Seq_LNCaP_Human1.45329621
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44941223
58DROSHA_22980978_ChIP-Seq_HELA_Human1.44422239
59* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44297398
60* KDM2B_26808549_Chip-Seq_DND41_Human1.44263674
61SPI1_23127762_ChIP-Seq_K562_Human1.44140683
62* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43847618
63* KDM2B_26808549_Chip-Seq_JURKAT_Human1.43732569
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.43329680
65AR_25329375_ChIP-Seq_VCAP_Human1.42541116
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.42478935
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41816317
68* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40752377
69BCAT_22108803_ChIP-Seq_LS180_Human1.40540538
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39700005
71* IRF8_27001747_Chip-Seq_BMDM_Mouse1.39460795
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39226315
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38833759
74* VDR_24787735_ChIP-Seq_THP-1_Human1.38724184
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.37997638
76* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37537712
77VDR_24763502_ChIP-Seq_THP-1_Human1.37425249
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37228681
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36461459
80CBP_20019798_ChIP-Seq_JUKART_Human1.36461459
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.36246518
82* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34543258
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.33582052
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33012783
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32082427
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31601555
87* FLI1_21867929_ChIP-Seq_TH2_Mouse1.31073426
88MYB_26560356_Chip-Seq_TH2_Human1.29233925
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28500229
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.27400828
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.27211478
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26402781
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25645173
94* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25025074
95* REST_21632747_ChIP-Seq_MESCs_Mouse1.24993856
96* RUNX2_22187159_ChIP-Seq_PCA_Human1.23893435
97MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23605991
98IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23201450
99* SOX2_21211035_ChIP-Seq_LN229_Gbm1.22831998
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21949983
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.21647789
102EZH2_27304074_Chip-Seq_ESCs_Mouse1.21146390
103JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20894326
104TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20150465
105RNF2_27304074_Chip-Seq_NSC_Mouse1.19740835
106SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19725687
107* TCF4_22108803_ChIP-Seq_LS180_Human1.19723409
108* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19717827
109CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19663243
110TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.18290298
111RXR_22108803_ChIP-Seq_LS180_Human1.18196847
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17786158
113MAF_26560356_Chip-Seq_TH1_Human1.17691213
114BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17381099
115NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16682602
116* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16398227
117IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16385125
118* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15264411
119* KDM2B_26808549_Chip-Seq_K562_Human1.14824324
120NFE2_27457419_Chip-Seq_LIVER_Mouse1.12973991
121* KDM2B_26808549_Chip-Seq_REH_Human1.12864459
122RARB_27405468_Chip-Seq_BRAIN_Mouse1.12263439
123RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12249642
124ESR1_20079471_ChIP-ChIP_T-47D_Human1.11925140
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11219794
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11219794
127* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11199130
128SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10580966
129MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10428354
130CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10177827
131TP53_16413492_ChIP-PET_HCT116_Human1.09565292
132* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07817235
133* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07073191
134P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06522184
135* SMAD4_21799915_ChIP-Seq_A2780_Human1.06098392
136E2F1_18555785_Chip-Seq_ESCs_Mouse1.06013475
137AR_19668381_ChIP-Seq_PC3_Human1.05270365
138P53_22387025_ChIP-Seq_ESCs_Mouse1.05039868
139MYB_26560356_Chip-Seq_TH1_Human1.04724920
140POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04023199
141CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03689762
142* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03668055
143SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03550646
144UTX_26944678_Chip-Seq_JUKART_Human1.03475083
145FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02939660
146HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02454270
147MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01539960
148* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01162765
149EZH2_27294783_Chip-Seq_ESCs_Mouse1.00362747
150* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99562787
151* SMAD3_21741376_ChIP-Seq_ESCs_Human0.99187350
152TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99025305
153RING1B_27294783_Chip-Seq_NPCs_Mouse0.98899980
154SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98559292
155SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97708552
156* SMAD3_21741376_ChIP-Seq_HESCs_Human0.97490842
157* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97247573
158SMAD4_21741376_ChIP-Seq_EPCs_Human0.96891075
159BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96557123
160GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95474516
161TP63_17297297_ChIP-ChIP_HaCaT_Human0.95210755
162TAF15_26573619_Chip-Seq_HEK293_Human0.95190146
163* ISL1_27105846_Chip-Seq_CPCs_Mouse0.94878225
164CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94305287
165SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94170831
166RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93673880
167TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92686463
168EED_16625203_ChIP-ChIP_MESCs_Mouse0.92554257
169* PRDM14_20953172_ChIP-Seq_ESCs_Human0.92314324

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia4.04206672
2MP0000569_abnormal_digit_pigmentation3.35178137
3MP0002166_altered_tumor_susceptibility3.10429307
4MP0003787_abnormal_imprinting2.75052557
5MP0001835_abnormal_antigen_presentation2.68908410
6MP0002396_abnormal_hematopoietic_system2.58945900
7MP0008877_abnormal_DNA_methylation2.42869770
8MP0004510_myositis2.41212955
9MP0003890_abnormal_embryonic-extraembry2.35068156
10MP0002006_tumorigenesis2.33413928
11MP0001790_abnormal_immune_system2.30162187
12MP0005387_immune_system_phenotype2.30162187
13MP0004808_abnormal_hematopoietic_stem2.30024114
14MP0001800_abnormal_humoral_immune2.18751981
15MP0004145_abnormal_muscle_electrophysio2.18251797
16MP0005174_abnormal_tail_pigmentation2.16113023
17MP0000685_abnormal_immune_system1.97533869
18MP0000631_abnormal_neuroendocrine_gland1.96002575
19MP0003303_peritoneal_inflammation1.95633402
20MP0003646_muscle_fatigue1.94520888
21MP0000383_abnormal_hair_follicle1.94213687
22MP0002452_abnormal_antigen_presenting1.90538955
23MP0005409_darkened_coat_color1.76704051
24MP0002398_abnormal_bone_marrow1.76525731
25MP0003136_yellow_coat_color1.74388171
26MP0002420_abnormal_adaptive_immunity1.71729324
27MP0004859_abnormal_synaptic_plasticity1.71692872
28MP0001819_abnormal_immune_cell1.71094370
29MP0009278_abnormal_bone_marrow1.69993144
30MP0001986_abnormal_taste_sensitivity1.67552936
31MP0009046_muscle_twitch1.66992588
32MP0000465_gastrointestinal_hemorrhage1.66247391
33MP0001485_abnormal_pinna_reflex1.64936904
34MP0005423_abnormal_somatic_nervous1.63857225
35MP0002723_abnormal_immune_serum1.62851358
36MP0000427_abnormal_hair_cycle1.60914151
37MP0000372_irregular_coat_pigmentation1.56476705
38MP0000015_abnormal_ear_pigmentation1.56279991
39MP0005551_abnormal_eye_electrophysiolog1.53796474
40MP0005000_abnormal_immune_tolerance1.51939083
41MP0005671_abnormal_response_to1.50472179
42MP0003283_abnormal_digestive_organ1.47937491
43MP0000716_abnormal_immune_system1.47337869
44MP0000703_abnormal_thymus_morphology1.46265259
45MP0003763_abnormal_thymus_physiology1.45848219
46MP0004043_abnormal_pH_regulation1.39625965
47MP0002095_abnormal_skin_pigmentation1.39181304
48MP0002638_abnormal_pupillary_reflex1.36623681
49MP0001501_abnormal_sleep_pattern1.35951080
50MP0005310_abnormal_salivary_gland1.35331535
51MP0002933_joint_inflammation1.30132551
52MP0003300_gastrointestinal_ulcer1.29757304
53MP0005220_abnormal_exocrine_pancreas1.27212996
54MP0005076_abnormal_cell_differentiation1.26521352
55MP0005464_abnormal_platelet_physiology1.25259305
56MP0002148_abnormal_hypersensitivity_rea1.23340071
57MP0002877_abnormal_melanocyte_morpholog1.22875983
58MP0005397_hematopoietic_system_phenotyp1.22697023
59MP0001545_abnormal_hematopoietic_system1.22697023
60MP0004133_heterotaxia1.22114162
61MP0000689_abnormal_spleen_morphology1.21868253
62MP0008995_early_reproductive_senescence1.21693519
63MP0004142_abnormal_muscle_tone1.21389836
64MP0002876_abnormal_thyroid_physiology1.20896193
65MP0001879_abnormal_lymphatic_vessel1.20623620
66MP0004924_abnormal_behavior1.20130656
67MP0005386_behavior/neurological_phenoty1.20130656
68MP0003436_decreased_susceptibility_to1.19246977
69MP0002822_catalepsy1.18539387
70MP0002751_abnormal_autonomic_nervous1.18124967
71MP0006292_abnormal_olfactory_placode1.16848736
72MP0003635_abnormal_synaptic_transmissio1.15806491
73MP0002722_abnormal_immune_system1.15355393
74MP0005646_abnormal_pituitary_gland1.14858624
75MP0002272_abnormal_nervous_system1.14495133
76MP0004381_abnormal_hair_follicle1.13197039
77MP0002067_abnormal_sensory_capabilities1.12721077
78MP0002419_abnormal_innate_immunity1.12072616
79MP0006072_abnormal_retinal_apoptosis1.11254460
80MP0003567_abnormal_fetal_cardiomyocyte1.10925751
81MP0003195_calcinosis1.10379494
82MP0004885_abnormal_endolymph1.10252344
83MP0005253_abnormal_eye_physiology1.08596255
84MP0001188_hyperpigmentation1.08576112
85MP0003880_abnormal_central_pattern1.07499893
86MP0000778_abnormal_nervous_system1.07466311
87MP0005025_abnormal_response_to1.07219368
88MP0010678_abnormal_skin_adnexa1.05758262
89MP0002429_abnormal_blood_cell1.04935122
90MP0003121_genomic_imprinting1.04623871
91MP0005645_abnormal_hypothalamus_physiol1.04150323
92MP0002405_respiratory_system_inflammati1.03325777
93MP0010155_abnormal_intestine_physiology1.03014271
94MP0001984_abnormal_olfaction1.02679548
95MP0002102_abnormal_ear_morphology1.02008450
96MP0002064_seizures1.01747646
97MP0002063_abnormal_learning/memory/cond1.01050115
98MP0006276_abnormal_autonomic_nervous1.00561816
99MP0002998_abnormal_bone_remodeling0.99166195
100MP0001348_abnormal_lacrimal_gland0.98800965
101MP0002938_white_spotting0.98582847
102MP0002168_other_aberrant_phenotype0.97491585
103MP0001851_eye_inflammation0.95988967
104MP0003937_abnormal_limbs/digits/tail_de0.94797902
105MP0003866_abnormal_defecation0.93683495
106MP0004130_abnormal_muscle_cell0.92131511
107MP0004742_abnormal_vestibular_system0.92031943
108MP0000955_abnormal_spinal_cord0.91636372
109MP0003943_abnormal_hepatobiliary_system0.89847280
110MP0002572_abnormal_emotion/affect_behav0.89338991
111MP0002734_abnormal_mechanical_nocicepti0.89182597
112MP0009745_abnormal_behavioral_response0.88630814
113MP0001873_stomach_inflammation0.88526741
114MP0003045_fibrosis0.86834201
115MP0008569_lethality_at_weaning0.86523992
116MP0008872_abnormal_physiological_respon0.86066807
117MP0003091_abnormal_cell_migration0.84426127
118MP0008961_abnormal_basal_metabolism0.83259075
119MP0002160_abnormal_reproductive_system0.83184650
120MP0003861_abnormal_nervous_system0.82532198
121MP0001502_abnormal_circadian_rhythm0.82188525
122MP0002752_abnormal_somatic_nervous0.81316555
123MP0002928_abnormal_bile_duct0.80652342
124MP0001944_abnormal_pancreas_morphology0.80156378
125MP0002882_abnormal_neuron_morphology0.79933182
126MP0002152_abnormal_brain_morphology0.78966397
127MP0004270_analgesia0.78636324
128MP0005171_absent_coat_pigmentation0.78443351
129MP0009115_abnormal_fat_cell0.78355505
130MP0003724_increased_susceptibility_to0.78216973
131MP0003935_abnormal_craniofacial_develop0.77971433
132MP0001286_abnormal_eye_development0.77547179
133MP0000470_abnormal_stomach_morphology0.75882570
134MP0002837_dystrophic_cardiac_calcinosis0.75536789
135MP0010386_abnormal_urinary_bladder0.75214674
136MP0004215_abnormal_myocardial_fiber0.74855334
137MP0002108_abnormal_muscle_morphology0.74484357
138MP0009703_decreased_birth_body0.74455089
139MP0001486_abnormal_startle_reflex0.73750014
140MP0002138_abnormal_hepatobiliary_system0.72633948
141MP0001324_abnormal_eye_pigmentation0.71772661
142MP0002249_abnormal_larynx_morphology0.71698449
143MP0005195_abnormal_posterior_eye0.71427571
144MP0003385_abnormal_body_wall0.70820008
145MP0003828_pulmonary_edema0.70105074
146MP0005075_abnormal_melanosome_morpholog0.69383998
147MP0004947_skin_inflammation0.68897064
148MP0000767_abnormal_smooth_muscle0.67317445
149MP0002557_abnormal_social/conspecific_i0.65909337
150MP0003122_maternal_imprinting0.63509900
151MP0001968_abnormal_touch/_nociception0.62262136
152MP0009785_altered_susceptibility_to0.60376714
153MP0002735_abnormal_chemical_nociception0.57591520
154MP0000733_abnormal_muscle_development0.57033584
155MP0004134_abnormal_chest_morphology0.55661393
156MP0004811_abnormal_neuron_physiology0.54666377
157MP0002163_abnormal_gland_morphology0.53344185
158MP0002925_abnormal_cardiovascular_devel0.53119916
159MP0002909_abnormal_adrenal_gland0.52886213
160MP0001533_abnormal_skeleton_physiology0.52100959
161MP0002184_abnormal_innervation0.51174759
162MP0009250_abnormal_appendicular_skeleto0.50435376
163MP0002075_abnormal_coat/hair_pigmentati0.49874271
164MP0008057_abnormal_DNA_replication0.49574187
165MP0002177_abnormal_outer_ear0.49038597

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.32295666
2Abnormality of the fingertips (HP:0001211)4.07868045
3Agammaglobulinemia (HP:0004432)3.98575496
4Progressive cerebellar ataxia (HP:0002073)3.57559839
5Cellulitis (HP:0100658)3.55626446
6Pancreatic cysts (HP:0001737)3.29139519
7Gaze-evoked nystagmus (HP:0000640)3.25247266
8Volvulus (HP:0002580)3.18427880
9Nephronophthisis (HP:0000090)3.13354236
10Absent frontal sinuses (HP:0002688)3.13005576
11Chronic hepatic failure (HP:0100626)3.11870679
12Thyroiditis (HP:0100646)2.98956890
13Abnormality of the renal medulla (HP:0100957)2.95071013
14Pancreatic fibrosis (HP:0100732)2.90826173
15True hermaphroditism (HP:0010459)2.80762286
16Syringomyelia (HP:0003396)2.78518929
17Spinal cord lesions (HP:0100561)2.78518929
18Aqueductal stenosis (HP:0002410)2.73670776
19Panhypogammaglobulinemia (HP:0003139)2.71296294
20Abnormality of midbrain morphology (HP:0002418)2.70317469
21Molar tooth sign on MRI (HP:0002419)2.70317469
22Meningitis (HP:0001287)2.66307804
23Verrucae (HP:0200043)2.64616836
24Papilloma (HP:0012740)2.64616836
25Abnormality of the renal cortex (HP:0011035)2.64589894
26Recurrent viral infections (HP:0004429)2.62344526
27Lip pit (HP:0100267)2.56702302
28Abnormal delayed hypersensitivity skin test (HP:0002963)2.53796878
29Recurrent fungal infections (HP:0002841)2.53634391
30Macroorchidism (HP:0000053)2.52451258
31Asymmetry of the thorax (HP:0001555)2.41167905
32Fair hair (HP:0002286)2.39182170
33Cystic liver disease (HP:0006706)2.38260834
34Congenital stationary night blindness (HP:0007642)2.38006809
35Neoplasm of the adrenal cortex (HP:0100641)2.35064968
36Stomach cancer (HP:0012126)2.34678739
37Hypoplastic ischia (HP:0003175)2.34205657
38Abnormal hair whorl (HP:0010721)2.27427118
39Tubular atrophy (HP:0000092)2.27365480
40Long eyelashes (HP:0000527)2.26325967
41Clumsiness (HP:0002312)2.26135543
42Hypoplastic labia majora (HP:0000059)2.25023671
43Widely spaced teeth (HP:0000687)2.21070727
44Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.18080593
45Tapered finger (HP:0001182)2.17628533
46Abnormality of the ischium (HP:0003174)2.16884193
47Inappropriate behavior (HP:0000719)2.15299701
48Intestinal atresia (HP:0011100)2.14452722
49Chronic mucocutaneous candidiasis (HP:0002728)2.13366314
50Recurrent cutaneous fungal infections (HP:0011370)2.13366314
51Abnormality of the labia majora (HP:0012881)2.12766838
52Tented upper lip vermilion (HP:0010804)2.11634598
53Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.10523286
54Recurrent abscess formation (HP:0002722)2.10344677
55Prolonged bleeding time (HP:0003010)2.09755635
56Absent speech (HP:0001344)2.09723735
57Hypoplastic iliac wings (HP:0002866)2.08919972
58Abnormality of the frontal sinuses (HP:0002687)2.07813020
59Abnormality of the nasal septum (HP:0000419)2.07005893
60Abnormality of the labia minora (HP:0012880)2.04465556
61Acute lymphatic leukemia (HP:0006721)2.02693075
62Febrile seizures (HP:0002373)2.00426177
63Attenuation of retinal blood vessels (HP:0007843)1.98596920
64Genetic anticipation (HP:0003743)1.98015636
65* Abnormality of the intervertebral disk (HP:0005108)1.97562144
66Cupped ear (HP:0000378)1.96478838
67Recurrent bacterial skin infections (HP:0005406)1.96119206
68Narrow palate (HP:0000189)1.94000913
69* Thick eyebrow (HP:0000574)1.93908732
70Chronic otitis media (HP:0000389)1.93042964
71Acute myeloid leukemia (HP:0004808)1.92248997
72Mediastinal lymphadenopathy (HP:0100721)1.90622308
73Abnormality of incisor morphology (HP:0011063)1.89431678
74Ectopic kidney (HP:0000086)1.88494137
75Medial flaring of the eyebrow (HP:0010747)1.88096422
76Vertebral arch anomaly (HP:0008438)1.87676921
77Abnormality of the pubic bones (HP:0003172)1.86916388
78Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.85242236
79Lower limb amyotrophy (HP:0007210)1.83757486
80Focal seizures (HP:0007359)1.83744380
81Generalized hypopigmentation of hair (HP:0011358)1.83638263
82Hyperkalemia (HP:0002153)1.83135619
83Type II lissencephaly (HP:0007260)1.82701841
84Colitis (HP:0002583)1.82342930
85Protruding tongue (HP:0010808)1.81997373
86Impaired smooth pursuit (HP:0007772)1.81339735
87Poor coordination (HP:0002370)1.80920949
88* Highly arched eyebrow (HP:0002553)1.79881853
89Sepsis (HP:0100806)1.79509525
90Keratoconus (HP:0000563)1.79323578
91Increased corneal curvature (HP:0100692)1.79323578
92Decreased circulating renin level (HP:0003351)1.79233108
93Neoplasm of the oral cavity (HP:0100649)1.79225258
94Osteomyelitis (HP:0002754)1.78061150
95Congenital hepatic fibrosis (HP:0002612)1.77826755
96Broad-based gait (HP:0002136)1.77645376
97Genital tract atresia (HP:0001827)1.77614883
98Truncal obesity (HP:0001956)1.77418989
99B lymphocytopenia (HP:0010976)1.77096766
100Abnormality of B cell number (HP:0010975)1.77096766
101Blue irides (HP:0000635)1.76939029
102* Patellar aplasia (HP:0006443)1.76717236
103Obstructive lung disease (HP:0006536)1.75317597
104Chronic obstructive pulmonary disease (HP:0006510)1.75317597
105Urinary bladder sphincter dysfunction (HP:0002839)1.74838407
106Myositis (HP:0100614)1.74403956
107Distal lower limb amyotrophy (HP:0008944)1.73807925
108Short chin (HP:0000331)1.73750117
109Colon cancer (HP:0003003)1.73532975
110Facial diplegia (HP:0001349)1.73432217
111Glioma (HP:0009733)1.72690169
112Abnormality of the renal collecting system (HP:0004742)1.72261527
113Eosinophilia (HP:0001880)1.71905341
114Hyperacusis (HP:0010780)1.71032846
115Astrocytoma (HP:0009592)1.71029790
116Abnormality of the astrocytes (HP:0100707)1.71029790
117Oligodactyly (hands) (HP:0001180)1.70828695
118Bony spicule pigmentary retinopathy (HP:0007737)1.70747823
119Hepatoblastoma (HP:0002884)1.70686549
120Inability to walk (HP:0002540)1.70292383
121Chronic sinusitis (HP:0011109)1.70070860
122Abnormality of the columella (HP:0009929)1.69923242
123Vaginal atresia (HP:0000148)1.69796241
124Prostate neoplasm (HP:0100787)1.69731257
125Duplicated collecting system (HP:0000081)1.69363547
126Obstructive sleep apnea (HP:0002870)1.69283270
127Midline defect of the nose (HP:0004122)1.69051929
128Aplasia/Hypoplasia of the tibia (HP:0005772)1.69046936
129Abnormality of the axillary hair (HP:0100134)1.68058389
130Abnormality of secondary sexual hair (HP:0009888)1.68058389
131Viral hepatitis (HP:0006562)1.67805548
132Tubulointerstitial nephritis (HP:0001970)1.67441629
133Chest pain (HP:0100749)1.66980847
134Cutaneous finger syndactyly (HP:0010554)1.64844974
135Deeply set eye (HP:0000490)1.64636969
136Abnormal drinking behavior (HP:0030082)1.64536263
137Polydipsia (HP:0001959)1.64536263
138Furrowed tongue (HP:0000221)1.64352712
139Papillary thyroid carcinoma (HP:0002895)1.63767328
140Dialeptic seizures (HP:0011146)1.63551332
141Epileptic encephalopathy (HP:0200134)1.63463930
142Abnormality of eosinophils (HP:0001879)1.63209209
143Lissencephaly (HP:0001339)1.62636307
144Inflammation of the large intestine (HP:0002037)1.62629548
145Stereotypic behavior (HP:0000733)1.62617475
146Cerebellar dysplasia (HP:0007033)1.62002346
147Excessive salivation (HP:0003781)1.61824806
148Drooling (HP:0002307)1.61824806
149Gastrointestinal stroma tumor (HP:0100723)1.60919906
150Fatigue (HP:0012378)1.60787425
151Anencephaly (HP:0002323)1.60752515
152Short foot (HP:0001773)1.60491103
153Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.60286674
154Short 4th metacarpal (HP:0010044)1.60286674
155Tracheomalacia (HP:0002779)1.59874564
156Gait imbalance (HP:0002141)1.59629926
157Periodontitis (HP:0000704)1.59377973
158Sparse scalp hair (HP:0002209)1.57476840
159Oligodontia (HP:0000677)1.57155068
1602-3 toe syndactyly (HP:0004691)1.55651178
161Chin dimple (HP:0010751)1.55197392
162Hematochezia (HP:0002573)1.54329398
163Leukocytosis (HP:0001974)1.54175138
164Optic neuritis (HP:0100653)1.54073360
165Retrobulbar optic neuritis (HP:0100654)1.54073360
166Vasculitis (HP:0002633)1.53076054
167Hypoplasia of the maxilla (HP:0000327)1.52373707
168Submucous cleft hard palate (HP:0000176)1.52028129
169Increased number of teeth (HP:0011069)1.51958163
170Recurrent bronchitis (HP:0002837)1.49906340
171Gastrointestinal inflammation (HP:0004386)1.49558396
172Dislocated radial head (HP:0003083)1.48340522
173Obsessive-compulsive behavior (HP:0000722)1.48173913
174Large earlobe (HP:0009748)1.47937029
175Arterial thrombosis (HP:0004420)1.47757471
176Disinhibition (HP:0000734)1.46581408
177Trigonocephaly (HP:0000243)1.46338410
178Abnormality of the prostate (HP:0008775)1.45560045

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.03166144
2TNIK2.85968312
3ACVR1B2.76275097
4EEF2K2.45173677
5SIK22.31858953
6AKT32.19331181
7BMPR22.13192585
8MAP4K12.09959785
9RIPK41.97574143
10PNCK1.81932316
11DMPK1.81525109
12FGFR31.75738392
13FES1.74226613
14MAP3K141.71693994
15NLK1.69789604
16SGK21.65462065
17JAK31.63509705
18HIPK21.62704455
19CASK1.60507456
20MKNK21.55874539
21CAMK1G1.55715842
22MAPK131.55006442
23SGK31.50282039
24PRKD21.48624340
25CDK91.45700422
26INSRR1.44461648
27KIT1.44450227
28SYK1.42030750
29TAOK31.38634730
30CLK11.38233893
31MAP3K41.36140523
32WNK31.35756960
33SIK31.35600446
34WNK11.35430427
35CHUK1.33773677
36IKBKB1.32358993
37GRK11.26466660
38MAP4K21.25733181
39MARK11.24128552
40CDK121.18845580
41MAP3K61.15782258
42MARK21.14902059
43LATS11.14051888
44IKBKE1.13210599
45BTK1.11348776
46GRK61.09854226
47RPS6KA21.09332751
48ADRBK21.08977618
49HCK1.08407336
50FRK1.06352764
51CSF1R1.05911902
52TAF11.05385459
53TNK21.02392867
54MKNK11.01863794
55BMPR1B1.01278298
56IRAK41.01209669
57STK240.98299111
58DAPK20.97889077
59RPS6KA60.97337440
60STK390.96833033
61PRPF4B0.96293055
62JAK10.94541391
63NTRK20.90147236
64PIM10.89250184
65RPS6KL10.86207194
66RPS6KC10.86207194
67TRPM70.84697012
68STK40.83005527
69MUSK0.82940875
70MAP3K120.82857833
71YES10.82040569
72PKN10.81316001
73STK38L0.81071687
74NTRK30.80583716
75MELK0.80197588
76SGK4940.79768218
77SGK2230.79768218
78TYK20.79537813
79OBSCN0.79373702
80PINK10.79022593
81OXSR10.78890820
82MAPK40.77963470
83TEC0.77607031
84BRD40.77581547
85MATK0.77571799
86PAK30.76628165
87SGK10.73800944
88STK30.72276436
89MAPK150.71923356
90PRKCH0.71778032
91TXK0.70798942
92PRKAA10.70160370
93MAP3K70.69469950
94LCK0.69095962
95RPS6KB10.66862199
96CDK30.66754122
97STK110.65994486
98ZAK0.65687424
99EPHA30.65196757
100FGFR20.64319898
101CAMK40.64181060
102WNK40.63257945
103ERBB30.61241078
104UHMK10.60892367
105TRIB30.59975264
106NUAK10.59529602
107IRAK10.57532266
108TAOK10.57227588
109PDGFRB0.56558406
110CAMK1D0.56499452
111MAP3K130.56321339
112ALK0.55842466
113ITK0.55607924
114CAMK10.54188999
115LYN0.54185539
116MAP2K70.53377348
117TGFBR10.52231428
118RET0.51542670
119ATM0.50686613
120PRKCE0.49475344
121ERBB20.48993411
122PIK3CG0.48436511
123ADRBK10.46931493
124TLK10.46539336
125MAPK30.45938405
126VRK10.45391824
127ZAP700.43935114
128CDK60.43334576
129FGR0.42859051
130DYRK1A0.42850673
131PRKAA20.42265989
132BRSK20.41681434
133MTOR0.41675819
134DYRK20.41330419
135PLK40.41038977
136ATR0.40868507
137MAPK80.40104821
138PTK2B0.39730884
139ABL10.39655477
140JAK20.39647478
141CDK50.39409872
142PIK3CA0.39012076
143GSK3B0.38058912
144TYRO30.37951777
145MAPK70.37706512
146PRKG10.34925689
147CSNK1D0.34190983
148CDC42BPA0.33752371
149PRKCQ0.33609879
150MAPK10.33388319
151PRKCG0.33367363
152AKT10.32771176
153RPS6KA30.32741941

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.07429756
2B cell receptor signaling pathway_Homo sapiens_hsa046622.05859119
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.05254581
4Phototransduction_Homo sapiens_hsa047441.82633846
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74105304
6Linoleic acid metabolism_Homo sapiens_hsa005911.67926354
7Primary immunodeficiency_Homo sapiens_hsa053401.62939030
8ABC transporters_Homo sapiens_hsa020101.59725527
9Osteoclast differentiation_Homo sapiens_hsa043801.53838869
10Ether lipid metabolism_Homo sapiens_hsa005651.50984528
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47697617
12Olfactory transduction_Homo sapiens_hsa047401.47081099
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46026893
14Insulin secretion_Homo sapiens_hsa049111.42637242
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40986520
16Chronic myeloid leukemia_Homo sapiens_hsa052201.31805473
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.28337760
18Fanconi anemia pathway_Homo sapiens_hsa034601.28058494
19Acute myeloid leukemia_Homo sapiens_hsa052211.27970998
20Neurotrophin signaling pathway_Homo sapiens_hsa047221.26739387
21Non-small cell lung cancer_Homo sapiens_hsa052231.26219526
22Glioma_Homo sapiens_hsa052141.25460257
23Circadian rhythm_Homo sapiens_hsa047101.24465481
24Chemokine signaling pathway_Homo sapiens_hsa040621.24343919
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24067665
26T cell receptor signaling pathway_Homo sapiens_hsa046601.23125402
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22345887
28Nitrogen metabolism_Homo sapiens_hsa009101.22342645
29Platelet activation_Homo sapiens_hsa046111.21900018
30Butanoate metabolism_Homo sapiens_hsa006501.21527911
31Leishmaniasis_Homo sapiens_hsa051401.20338555
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20000647
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.19771194
34Prolactin signaling pathway_Homo sapiens_hsa049171.17783536
35Measles_Homo sapiens_hsa051621.16142984
36Endometrial cancer_Homo sapiens_hsa052131.15567916
37Circadian entrainment_Homo sapiens_hsa047131.15513449
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15092730
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14096059
40ErbB signaling pathway_Homo sapiens_hsa040121.13502068
41Homologous recombination_Homo sapiens_hsa034401.13336157
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10616297
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.10566946
44Dorso-ventral axis formation_Homo sapiens_hsa043201.10435499
45Morphine addiction_Homo sapiens_hsa050321.09495151
46Long-term potentiation_Homo sapiens_hsa047201.08446022
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08392021
48Non-homologous end-joining_Homo sapiens_hsa034501.07484488
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.06536546
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05933032
51Pancreatic cancer_Homo sapiens_hsa052121.04654043
52Glutamatergic synapse_Homo sapiens_hsa047241.04271657
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03218259
54Toxoplasmosis_Homo sapiens_hsa051451.02764595
55Cholinergic synapse_Homo sapiens_hsa047251.02687986
56Ovarian steroidogenesis_Homo sapiens_hsa049131.02015197
57GnRH signaling pathway_Homo sapiens_hsa049121.01965665
58MAPK signaling pathway_Homo sapiens_hsa040101.01600736
59Hepatitis B_Homo sapiens_hsa051611.00176110
60Renin secretion_Homo sapiens_hsa049241.00080003
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99159612
62Colorectal cancer_Homo sapiens_hsa052100.98886083
63Oxytocin signaling pathway_Homo sapiens_hsa049210.96309645
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96250293
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96149270
66Type II diabetes mellitus_Homo sapiens_hsa049300.95993087
67Selenocompound metabolism_Homo sapiens_hsa004500.95764912
68MicroRNAs in cancer_Homo sapiens_hsa052060.95418388
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94003643
70Nicotine addiction_Homo sapiens_hsa050330.93998952
71TNF signaling pathway_Homo sapiens_hsa046680.93487993
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93108196
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93000348
74Choline metabolism in cancer_Homo sapiens_hsa052310.92899688
75Estrogen signaling pathway_Homo sapiens_hsa049150.91306888
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91102404
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.90352433
78Basal cell carcinoma_Homo sapiens_hsa052170.90050306
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89769681
80Renal cell carcinoma_Homo sapiens_hsa052110.88777089
81Long-term depression_Homo sapiens_hsa047300.88656587
82Hematopoietic cell lineage_Homo sapiens_hsa046400.88180238
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86922845
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86273827
85Viral myocarditis_Homo sapiens_hsa054160.86093464
86Basal transcription factors_Homo sapiens_hsa030220.86060541
87Prostate cancer_Homo sapiens_hsa052150.85712922
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85606968
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84750270
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84240363
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83683211
92cAMP signaling pathway_Homo sapiens_hsa040240.83610519
93Dopaminergic synapse_Homo sapiens_hsa047280.83472866
94Gastric acid secretion_Homo sapiens_hsa049710.83243035
95FoxO signaling pathway_Homo sapiens_hsa040680.82616598
96Salivary secretion_Homo sapiens_hsa049700.81469262
97RNA degradation_Homo sapiens_hsa030180.80409156
98Influenza A_Homo sapiens_hsa051640.79768007
99Axon guidance_Homo sapiens_hsa043600.79764744
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79727729
101Notch signaling pathway_Homo sapiens_hsa043300.79341488
102Small cell lung cancer_Homo sapiens_hsa052220.79332999
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79256396
104Pancreatic secretion_Homo sapiens_hsa049720.78555780
105Taste transduction_Homo sapiens_hsa047420.78188832
106Herpes simplex infection_Homo sapiens_hsa051680.77983548
107Tryptophan metabolism_Homo sapiens_hsa003800.77505275
108Inositol phosphate metabolism_Homo sapiens_hsa005620.75293893
109TGF-beta signaling pathway_Homo sapiens_hsa043500.74382196
110Dilated cardiomyopathy_Homo sapiens_hsa054140.74377173
111Asthma_Homo sapiens_hsa053100.74322269
112Amphetamine addiction_Homo sapiens_hsa050310.74311362
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73337677
114Serotonergic synapse_Homo sapiens_hsa047260.72198977
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71627764
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71514617
117Hedgehog signaling pathway_Homo sapiens_hsa043400.71452349
118Tuberculosis_Homo sapiens_hsa051520.71333310
119Focal adhesion_Homo sapiens_hsa045100.70577661
120VEGF signaling pathway_Homo sapiens_hsa043700.70307561
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.68573511
122Melanogenesis_Homo sapiens_hsa049160.68046079
123Apoptosis_Homo sapiens_hsa042100.67999788
124mTOR signaling pathway_Homo sapiens_hsa041500.67364854
125Cocaine addiction_Homo sapiens_hsa050300.66976802
126Pathways in cancer_Homo sapiens_hsa052000.66880242
127Wnt signaling pathway_Homo sapiens_hsa043100.65906727
128Shigellosis_Homo sapiens_hsa051310.64862209
129Hepatitis C_Homo sapiens_hsa051600.64270160
130Melanoma_Homo sapiens_hsa052180.64074589
131GABAergic synapse_Homo sapiens_hsa047270.64000543
132Calcium signaling pathway_Homo sapiens_hsa040200.63996910
133Ras signaling pathway_Homo sapiens_hsa040140.63537989
134Glycerolipid metabolism_Homo sapiens_hsa005610.63512072
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.63495074
136Proteoglycans in cancer_Homo sapiens_hsa052050.63214080
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.62708563
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62264692
139Hippo signaling pathway_Homo sapiens_hsa043900.59167455
140Insulin resistance_Homo sapiens_hsa049310.59135262
141mRNA surveillance pathway_Homo sapiens_hsa030150.59128892
142Glucagon signaling pathway_Homo sapiens_hsa049220.57015962
143Type I diabetes mellitus_Homo sapiens_hsa049400.54146121
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.54018067
145Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53771385

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