ARID3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)5.60827364
2regulation of gene silencing by miRNA (GO:0060964)5.60827364
3regulation of gene silencing by RNA (GO:0060966)5.60827364
4behavioral response to nicotine (GO:0035095)4.75506564
5cell proliferation in forebrain (GO:0021846)4.61129181
6viral transcription (GO:0019083)4.46002001
7leukocyte aggregation (GO:0070486)4.13379282
8neutrophil activation involved in immune response (GO:0002283)4.07702597
9translational termination (GO:0006415)4.04966627
10regulation of activation of Janus kinase activity (GO:0010533)3.90186750
11cellular response to ATP (GO:0071318)3.89663880
12ribosomal small subunit biogenesis (GO:0042274)3.85813147
13nuclear pore complex assembly (GO:0051292)3.75020139
14lung morphogenesis (GO:0060425)3.74198749
15neutrophil activation (GO:0042119)3.65536801
16sulfation (GO:0051923)3.59863097
17water-soluble vitamin biosynthetic process (GO:0042364)3.59393673
18cellular anion homeostasis (GO:0030002)3.55971227
19respiratory burst (GO:0045730)3.55960312
20response to peptidoglycan (GO:0032494)3.53562726
21negative regulation of phagocytosis (GO:0050765)3.43052465
22negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.38561913
23tooth mineralization (GO:0034505)3.38331251
24nuclear pore organization (GO:0006999)3.34882707
25granulocyte activation (GO:0036230)3.34662442
26negative regulation of gene silencing (GO:0060969)3.30039437
27regulation of glomerulus development (GO:0090192)3.27938150
28somite development (GO:0061053)3.27477938
29regulation of cholesterol storage (GO:0010885)3.26258859
30hepatocyte apoptotic process (GO:0097284)3.25676346
31cellular extravasation (GO:0045123)3.24793117
32Arp2/3 complex-mediated actin nucleation (GO:0034314)3.23147137
33translational elongation (GO:0006414)3.22566280
34endoderm formation (GO:0001706)3.22211059
35basic amino acid transport (GO:0015802)3.21967959
36regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.20646946
37pre-miRNA processing (GO:0031054)3.20189063
38DNA deamination (GO:0045006)3.18574714
39regulation of B cell receptor signaling pathway (GO:0050855)3.18121800
40protein localization to kinetochore (GO:0034501)3.18016513
41maturation of SSU-rRNA (GO:0030490)3.16681055
42erythrocyte maturation (GO:0043249)3.11898833
433-UTR-mediated mRNA stabilization (GO:0070935)3.10858254
44heterochromatin organization (GO:0070828)3.10490453
45regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.08515126
46positive regulation of gamma-delta T cell activation (GO:0046645)3.07933934
47B cell receptor signaling pathway (GO:0050853)3.04501041
48pore complex assembly (GO:0046931)3.04320021
49regulation of mesoderm development (GO:2000380)3.03598839
50positive regulation of megakaryocyte differentiation (GO:0045654)3.00624493
51positive regulation by symbiont of host defense response (GO:0052509)2.99667281
52modulation by symbiont of host defense response (GO:0052031)2.99667281
53modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.99667281
54modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.99667281
55positive regulation by organism of defense response of other organism involved in symbiotic interact2.99667281
56modulation by symbiont of host immune response (GO:0052553)2.99667281
57positive regulation of T cell apoptotic process (GO:0070234)2.99205516
58RNA stabilization (GO:0043489)2.98715044
59mRNA stabilization (GO:0048255)2.98715044
60DNA unwinding involved in DNA replication (GO:0006268)2.98575034
61positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.98521279
62viral life cycle (GO:0019058)2.94394692
63response to fungus (GO:0009620)2.94318488
64SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.93777406
65plasma lipoprotein particle clearance (GO:0034381)2.93638561
66nephron tubule morphogenesis (GO:0072078)2.92667903
67nephron epithelium morphogenesis (GO:0072088)2.92667903
68positive regulation of lymphocyte apoptotic process (GO:0070230)2.92474859
69negative regulation of astrocyte differentiation (GO:0048712)2.91141840
70protein targeting to ER (GO:0045047)2.90826665
71regulation of interferon-gamma biosynthetic process (GO:0045072)2.87048774
72cotranslational protein targeting to membrane (GO:0006613)2.86768153
73negative regulation of transcription regulatory region DNA binding (GO:2000678)2.84989006
74negative regulation of DNA-templated transcription, elongation (GO:0032785)2.84981176
75protein localization to chromosome, centromeric region (GO:0071459)2.84827624
76leukocyte migration involved in inflammatory response (GO:0002523)2.81720383
77regulation of non-canonical Wnt signaling pathway (GO:2000050)2.79762712
78nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.79490464
79response to muramyl dipeptide (GO:0032495)2.75205658
80cellular response to zinc ion (GO:0071294)2.74993443
81cellular protein complex disassembly (GO:0043624)2.73806732
82pituitary gland development (GO:0021983)2.73543522
83positive regulation of fatty acid beta-oxidation (GO:0032000)2.73191959
84regulation of transcription regulatory region DNA binding (GO:2000677)2.73160713
85plasma lipoprotein particle assembly (GO:0034377)2.72590563
86negative regulation of fibrinolysis (GO:0051918)2.72347544
87chromatin assembly (GO:0031497)2.71362441
88trivalent inorganic anion homeostasis (GO:0072506)2.69729965
89phosphate ion homeostasis (GO:0055062)2.69729965
90establishment of protein localization to endoplasmic reticulum (GO:0072599)2.69614218
91neutrophil mediated immunity (GO:0002446)2.69534398
92low-density lipoprotein particle remodeling (GO:0034374)2.68991578
93regulation of chromatin binding (GO:0035561)2.68698342
94negative regulation of response to food (GO:0032096)2.68164268
95negative regulation of appetite (GO:0032099)2.68164268
96interferon-gamma secretion (GO:0072643)2.67949450
97indole-containing compound catabolic process (GO:0042436)2.67918041
98indolalkylamine catabolic process (GO:0046218)2.67918041
99tryptophan catabolic process (GO:0006569)2.67918041
100sequestering of metal ion (GO:0051238)2.67917909
101genetic imprinting (GO:0071514)2.67601742
102protein localization to endoplasmic reticulum (GO:0070972)2.67436525
103positive regulation of B cell differentiation (GO:0045579)2.66664716
104regulation of B cell differentiation (GO:0045577)2.65159978
105intestinal cholesterol absorption (GO:0030299)2.64896191
106sister chromatid segregation (GO:0000819)2.63986914
107kynurenine metabolic process (GO:0070189)2.62627897
108lung-associated mesenchyme development (GO:0060484)2.62396946
109immunoglobulin mediated immune response (GO:0016064)2.62005069
110dosage compensation (GO:0007549)2.61913818
111negative regulation of histone methylation (GO:0031061)2.60162122
112positive regulation of cAMP-mediated signaling (GO:0043950)2.58939107
113defense response to fungus (GO:0050832)2.58785953
114DNA replication checkpoint (GO:0000076)2.56874724
115kidney morphogenesis (GO:0060993)2.56408796
116mitotic sister chromatid segregation (GO:0000070)2.56131650
117negative regulation of B cell proliferation (GO:0030889)2.54263148
118regulation of cell proliferation involved in kidney development (GO:1901722)2.54104347
119negative regulation of telomere maintenance (GO:0032205)2.53082493
120regulation of interferon-beta biosynthetic process (GO:0045357)2.53002276
121indolalkylamine metabolic process (GO:0006586)2.52354378
122regulation of histone H3-K9 methylation (GO:0051570)2.51746465
1233-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.51248601
124purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.51248601
125negative regulation of RNA splicing (GO:0033119)2.50227605
126macrophage activation involved in immune response (GO:0002281)2.47329825
127kinetochore organization (GO:0051383)2.46815477
128regulation of mast cell degranulation (GO:0043304)2.46257105
129negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.45968883
130negative regulation of cell killing (GO:0031342)2.45968883
131protein complex disassembly (GO:0043241)2.44779527
132cell migration involved in gastrulation (GO:0042074)2.43552692
133trophectodermal cell differentiation (GO:0001829)2.43491594
134otic vesicle formation (GO:0030916)2.43315804
135mitotic sister chromatid cohesion (GO:0007064)2.43126692
136mitotic chromosome condensation (GO:0007076)2.41787472
137tolerance induction (GO:0002507)2.41127954
138establishment of protein localization to mitochondrial membrane (GO:0090151)2.40185624
139regulation of interferon-alpha production (GO:0032647)2.39923319
140NAD biosynthetic process (GO:0009435)2.39515891
141membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.38977681
142mitotic nuclear envelope disassembly (GO:0007077)2.38443725
143actin nucleation (GO:0045010)2.37900456
144defense response to protozoan (GO:0042832)2.36629387
145positive regulation of fatty acid oxidation (GO:0046321)2.36384012
146regulation of gene expression by genetic imprinting (GO:0006349)2.35076825
147antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.34963877
148positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.34930832
149positive regulation of triglyceride biosynthetic process (GO:0010867)2.34612711
150negative regulation of myeloid cell apoptotic process (GO:0033033)2.34243145
151positive regulation of defense response to virus by host (GO:0002230)2.33971696
152cytoplasmic mRNA processing body assembly (GO:0033962)2.31838286
153regulation of mast cell activation involved in immune response (GO:0033006)2.29806822
154negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.27748575
155B cell mediated immunity (GO:0019724)2.27486010
156leukocyte cell-cell adhesion (GO:0007159)2.27468242
157response to protozoan (GO:0001562)2.26252590
158DNA replication-dependent nucleosome organization (GO:0034723)2.25702895
159DNA replication-dependent nucleosome assembly (GO:0006335)2.25702895
160superoxide anion generation (GO:0042554)2.25590835
161protein-DNA complex disassembly (GO:0032986)2.25091930
162nucleosome disassembly (GO:0006337)2.25091930
163antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.25011940
164antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.25011940
165regulation of DNA endoreduplication (GO:0032875)2.23610072
166regulation of leukocyte degranulation (GO:0043300)2.23310946
167positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.22839747
168positive regulation of mast cell degranulation (GO:0043306)2.22812200
169positive regulation of mast cell activation involved in immune response (GO:0033008)2.22812200
170regulation of mRNA stability (GO:0043488)2.22658882
171DNA replication initiation (GO:0006270)2.22561482
172positive regulation of mast cell activation (GO:0033005)2.22331884
173antigen processing and presentation of endogenous antigen (GO:0019883)2.21629700
174DNA duplex unwinding (GO:0032508)2.20167305
175DNA geometric change (GO:0032392)2.20018241
176regulation of stem cell maintenance (GO:2000036)2.19073680
177regulation of myeloid leukocyte mediated immunity (GO:0002886)2.19030060
178positive regulation of interferon-alpha production (GO:0032727)2.18581545
179membrane disassembly (GO:0030397)2.18360898
180nuclear envelope disassembly (GO:0051081)2.18360898
181negative regulation of granulocyte differentiation (GO:0030853)2.17742241
182regulation of mast cell activation (GO:0033003)2.17104689
183ribosomal small subunit assembly (GO:0000028)2.16552533
184positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.16508899
185regulation of gene silencing (GO:0060968)2.15851185
186alternative mRNA splicing, via spliceosome (GO:0000380)2.15259805
187pinocytosis (GO:0006907)2.15023185
188regulation of RNA stability (GO:0043487)2.14753211

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.91786969
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.50069350
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.94693651
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.94516532
5EZH2_22144423_ChIP-Seq_EOC_Human3.39205812
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.34850355
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.29191147
8* MYC_22102868_ChIP-Seq_BL_Human3.17547794
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.15118211
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.11039684
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.92848496
12* VDR_21846776_ChIP-Seq_THP-1_Human2.75821628
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.74996492
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.66705741
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.65350829
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60867969
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.55882879
18IRF1_19129219_ChIP-ChIP_H3396_Human2.55387284
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40049617
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.36330734
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.36228302
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.27656589
23* IRF8_27001747_Chip-Seq_BMDM_Mouse2.25302818
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.22983301
25* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20272756
26BMI1_23680149_ChIP-Seq_NPCS_Mouse2.18371851
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.18346015
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.16515512
29SPI1_23547873_ChIP-Seq_NB4_Human2.14843870
30* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.05476348
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05131337
32SCL_19346495_ChIP-Seq_HPC-7_Human2.05028778
33* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04576536
34KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.03385822
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.03385822
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.03385822
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02743286
38* VDR_24763502_ChIP-Seq_THP-1_Human1.90564111
39MAF_26560356_Chip-Seq_TH1_Human1.89603539
40* TCF7_22412390_ChIP-Seq_EML_Mouse1.88862776
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87987704
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.85695613
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.82109305
44MYB_26560356_Chip-Seq_TH2_Human1.78948505
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78579923
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.75827675
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.74055088
48* UTX_26944678_Chip-Seq_JUKART_Human1.73434245
49* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.72585183
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.72086814
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69971020
52ZNF274_21170338_ChIP-Seq_K562_Hela1.68367776
53MYB_26560356_Chip-Seq_TH1_Human1.68099096
54YY1_22570637_ChIP-Seq_MALME-3M_Human1.65834251
55TDRD3_21172665_ChIP-Seq_MCF-7_Human1.62158776
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.59030704
57* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58109025
58EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.56892886
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54568421
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.51318691
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50153793
62CIITA_25753668_ChIP-Seq_RAJI_Human1.48177135
63BCL6_27268052_Chip-Seq_Bcells_Human1.46827312
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.46294636
65* P68_20966046_ChIP-Seq_HELA_Human1.46170826
66FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44306082
67* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44053740
68SPI1_23127762_ChIP-Seq_K562_Human1.41877122
69MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40217157
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.39909650
71STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.39409888
72ERA_21632823_ChIP-Seq_H3396_Human1.39382966
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38803553
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38263246
75RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.38074045
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.36966007
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35239942
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34794217
79MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34368421
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33679121
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.31933432
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.31420291
83E2F1_20622854_ChIP-Seq_HELA_Human1.30919811
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30773907
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30512482
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30460239
87SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30333355
88* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30195262
89ELK3_25401928_ChIP-Seq_HUVEC_Human1.29521579
90* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29130235
91PHF8_20622854_ChIP-Seq_HELA_Human1.28872596
92ELK1_19687146_ChIP-ChIP_HELA_Human1.28679846
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28175815
94TFEB_21752829_ChIP-Seq_HELA_Human1.27836728
95* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27590308
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.25134032
97TAF2_19829295_ChIP-Seq_ESCs_Human1.24422249
98KDM2B_26808549_Chip-Seq_DND41_Human1.24101968
99LXR_22292898_ChIP-Seq_THP-1_Human1.22439916
100RAC3_21632823_ChIP-Seq_H3396_Human1.22426809
101NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22268849
102* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22199937
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18881716
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18656163
105SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18560804
106XRN2_22483619_ChIP-Seq_HELA_Human1.18090695
107GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17100907
108GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17065803
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17042870
110* PU_27001747_Chip-Seq_BMDM_Mouse1.16581428
111RUNX_20019798_ChIP-Seq_JUKART_Human1.16389049
112ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.16249546
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14970570
114EZH2_27294783_Chip-Seq_ESCs_Mouse1.13306589
115MAF_26560356_Chip-Seq_TH2_Human1.13004258
116ELF1_20517297_ChIP-Seq_JURKAT_Human1.12282099
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12090112
118MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12011947
119GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11558539
120MYC_18940864_ChIP-ChIP_HL60_Human1.10884269
121NANOG_20526341_ChIP-Seq_ESCs_Human1.10571728
122KDM5A_27292631_Chip-Seq_BREAST_Human1.10045958
123BCOR_27268052_Chip-Seq_Bcells_Human1.08973893
124AR_21909140_ChIP-Seq_LNCAP_Human1.08769786
125* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06382085
126OCT4_19829295_ChIP-Seq_ESCs_Human1.05889046
127P300_27268052_Chip-Seq_Bcells_Human1.05338927
128NANOG_16153702_ChIP-ChIP_HESCs_Human1.05296447
129CTCF_20526341_ChIP-Seq_ESCs_Human1.05107013
130GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04734455
131* FOXP3_21729870_ChIP-Seq_TREG_Human1.04340142
132RNF2_27304074_Chip-Seq_NSC_Mouse1.04205403
133SPI1_20517297_ChIP-Seq_HL60_Human1.04124003
134TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04039659
135GATA1_26923725_Chip-Seq_HPCs_Mouse1.03911749
136* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03859807
137ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03743410
138SOX2_16153702_ChIP-ChIP_HESCs_Human1.03486761
139LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03466997
140NCOR1_26117541_ChIP-Seq_K562_Human1.03019661
141SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02993837
142EST1_17652178_ChIP-ChIP_JURKAT_Human1.02447852
143* FOXH1_21741376_ChIP-Seq_ESCs_Human1.02175854
144* RING1B_27294783_Chip-Seq_ESCs_Mouse1.01973722
145VDR_23849224_ChIP-Seq_CD4+_Human1.01925800
146VDR_22108803_ChIP-Seq_LS180_Human1.01892700
147MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01044437
148FOXP1_21924763_ChIP-Seq_HESCs_Human0.99549700
149POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98492854
150FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98422440
151* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97815010
152* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96853039
153HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96801927
154RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96405744
155RARA_24833708_ChIP-Seq_LIVER_Mouse0.95919447
156Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95514703
157PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95333330
158* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94710846
159RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94615935
160SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94578636
161BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.94265179
162E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93976836
163POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93602983
164MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92974023
165IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92613833
166REST_21632747_ChIP-Seq_MESCs_Mouse0.91888535
167ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91682169
168ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91348270
169RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90866017
170SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90136929
171GATA3_21878914_ChIP-Seq_MCF-7_Human0.89930061
172MYCN_18555785_ChIP-Seq_MESCs_Mouse0.89488913
173TTF2_22483619_ChIP-Seq_HELA_Human0.89484033
174KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89143537
175LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88463032
176SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88417942
177PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88207227
178* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85252080
179GATA3_27048872_Chip-Seq_THYMUS_Human0.84256947
180NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82766628

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.39773179
2MP0003303_peritoneal_inflammation3.70902195
3MP0003646_muscle_fatigue3.06645393
4MP0001835_abnormal_antigen_presentation2.81945881
5MP0003195_calcinosis2.58180010
6MP0005377_hearing/vestibular/ear_phenot2.57849106
7MP0003878_abnormal_ear_physiology2.57849106
8MP0003436_decreased_susceptibility_to2.49169690
9MP0003693_abnormal_embryo_hatching2.35474710
10MP0002396_abnormal_hematopoietic_system2.33293604
11MP0001800_abnormal_humoral_immune2.22128320
12MP0003111_abnormal_nucleus_morphology2.21281377
13MP0005076_abnormal_cell_differentiation2.18729366
14MP0003123_paternal_imprinting2.13308392
15MP0002163_abnormal_gland_morphology2.12427680
16MP0002138_abnormal_hepatobiliary_system2.12169430
17MP0003121_genomic_imprinting2.10884483
18MP0010094_abnormal_chromosome_stability2.10095373
19MP0003077_abnormal_cell_cycle2.09757035
20MP0002452_abnormal_antigen_presenting2.09335377
21MP0002160_abnormal_reproductive_system2.07726733
22MP0005646_abnormal_pituitary_gland2.05215908
23MP0010352_gastrointestinal_tract_polyps2.03961087
24MP0004133_heterotaxia2.03936945
25MP0005387_immune_system_phenotype1.99603545
26MP0001790_abnormal_immune_system1.99603545
27MP0000569_abnormal_digit_pigmentation1.99105279
28MP0010307_abnormal_tumor_latency1.95971889
29MP0005000_abnormal_immune_tolerance1.90209969
30MP0002419_abnormal_innate_immunity1.90159302
31MP0008057_abnormal_DNA_replication1.89133558
32MP0000049_abnormal_middle_ear1.88817791
33MP0002398_abnormal_bone_marrow1.88211567
34MP0002089_abnormal_postnatal_growth/wei1.87489631
35MP0002139_abnormal_hepatobiliary_system1.87425299
36MP0002420_abnormal_adaptive_immunity1.85754251
37MP0004808_abnormal_hematopoietic_stem1.85701738
38MP0009785_altered_susceptibility_to1.85082003
39MP0001819_abnormal_immune_cell1.83356960
40MP0005389_reproductive_system_phenotype1.83353807
41MP0009379_abnormal_foot_pigmentation1.82073814
42MP0003890_abnormal_embryonic-extraembry1.79276735
43MP0009278_abnormal_bone_marrow1.78694888
44MP0004264_abnormal_extraembryonic_tissu1.77350339
45MP0005671_abnormal_response_to1.76600524
46MP0000465_gastrointestinal_hemorrhage1.74852431
47MP0003938_abnormal_ear_development1.74764242
48MP0002723_abnormal_immune_serum1.74329006
49MP0002837_dystrophic_cardiac_calcinosis1.71837080
50MP0005360_urolithiasis1.71832050
51MP0002405_respiratory_system_inflammati1.71102389
52MP0005025_abnormal_response_to1.69952611
53MP0003566_abnormal_cell_adhesion1.66823745
54MP0000685_abnormal_immune_system1.65274358
55MP0004957_abnormal_blastocyst_morpholog1.63633667
56MP0005464_abnormal_platelet_physiology1.62427235
57MP0000678_abnormal_parathyroid_gland1.60263504
58MP0005379_endocrine/exocrine_gland_phen1.59551225
59MP0000490_abnormal_crypts_of1.59011805
60MP0000716_abnormal_immune_system1.58592193
61MP0003119_abnormal_digestive_system1.56725450
62MP0002148_abnormal_hypersensitivity_rea1.56222442
63MP0002254_reproductive_system_inflammat1.55013786
64MP0001293_anophthalmia1.52273502
65MP0000631_abnormal_neuroendocrine_gland1.51566310
66MP0002722_abnormal_immune_system1.51539781
67MP0000689_abnormal_spleen_morphology1.50883791
68MP0002429_abnormal_blood_cell1.47567319
69MP0008007_abnormal_cellular_replicative1.47096791
70MP0003011_delayed_dark_adaptation1.46696856
71MP0009333_abnormal_splenocyte_physiolog1.45786275
72MP0005084_abnormal_gallbladder_morpholo1.45215119
73MP0003122_maternal_imprinting1.44553793
74MP0002653_abnormal_ependyma_morphology1.44308904
75MP0003942_abnormal_urinary_system1.43925073
76MP0001919_abnormal_reproductive_system1.42284161
77MP0006054_spinal_hemorrhage1.37074011
78MP0003283_abnormal_digestive_organ1.36112315
79MP0005645_abnormal_hypothalamus_physiol1.36033757
80MP0000350_abnormal_cell_proliferation1.34702244
81MP0000703_abnormal_thymus_morphology1.32053674
82MP0003300_gastrointestinal_ulcer1.31426022
83MP0001485_abnormal_pinna_reflex1.29820740
84MP0000858_altered_metastatic_potential1.28669273
85MP0005174_abnormal_tail_pigmentation1.27794091
86MP0003567_abnormal_fetal_cardiomyocyte1.25895667
87MP0001730_embryonic_growth_arrest1.23300342
88MP0005397_hematopoietic_system_phenotyp1.23172334
89MP0001545_abnormal_hematopoietic_system1.23172334
90MP0010155_abnormal_intestine_physiology1.22049910
91MP0004197_abnormal_fetal_growth/weight/1.20782400
92MP0003448_altered_tumor_morphology1.19769267
93MP0002086_abnormal_extraembryonic_tissu1.19464399
94MP0008995_early_reproductive_senescence1.19158651
95MP0005167_abnormal_blood-brain_barrier1.18985479
96MP0003984_embryonic_growth_retardation1.18291689
97MP0002088_abnormal_embryonic_growth/wei1.16819494
98MP0001845_abnormal_inflammatory_respons1.16738334
99MP0005380_embryogenesis_phenotype1.16549025
100MP0001672_abnormal_embryogenesis/_devel1.16549025
101MP0004145_abnormal_muscle_electrophysio1.15528945
102MP0004130_abnormal_muscle_cell1.14863265
103MP0003724_increased_susceptibility_to1.13089222
104MP0008058_abnormal_DNA_repair1.11434674
105MP0002019_abnormal_tumor_incidence1.10957678
106MP0001915_intracranial_hemorrhage1.07603090
107MP0004947_skin_inflammation1.06672600
108MP0003937_abnormal_limbs/digits/tail_de1.05481055
109MP0001697_abnormal_embryo_size1.04992410
110MP0010329_abnormal_lipoprotein_level1.04902326
111MP0003705_abnormal_hypodermis_morpholog1.03756932
112MP0002938_white_spotting1.03295884
113MP0008872_abnormal_physiological_respon1.02449425
114MP0003183_abnormal_peptide_metabolism1.02136914
115MP0001533_abnormal_skeleton_physiology1.01811299
116MP0000313_abnormal_cell_death1.00643906
117MP0003879_abnormal_hair_cell1.00325308
118MP0004510_myositis0.99338334
119MP0004742_abnormal_vestibular_system0.99125216
120MP0003172_abnormal_lysosome_physiology0.96935067
121MP0005023_abnormal_wound_healing0.96577680
122MP0001873_stomach_inflammation0.95870622
123MP0005410_abnormal_fertilization0.94801449
124MP0004885_abnormal_endolymph0.94011982
125MP0006082_CNS_inflammation0.94004818
126MP0005058_abnormal_lysosome_morphology0.94004137
127MP0008932_abnormal_embryonic_tissue0.93691481
128MP0002933_joint_inflammation0.93472312
129MP0003763_abnormal_thymus_physiology0.93000710
130MP0000566_synostosis0.91137162
131MP0004185_abnormal_adipocyte_glucose0.90476775
132MP0004142_abnormal_muscle_tone0.90418484
133MP0002080_prenatal_lethality0.88895980
134MP0000015_abnormal_ear_pigmentation0.87781172
135MP0002166_altered_tumor_susceptibility0.87424782
136MP0002084_abnormal_developmental_patter0.87341156
137MP0002085_abnormal_embryonic_tissue0.85969754
138MP0002277_abnormal_respiratory_mucosa0.84458225
139MP0001348_abnormal_lacrimal_gland0.84088965
140MP0001851_eye_inflammation0.82780262
141MP0002249_abnormal_larynx_morphology0.81516206
142MP0000767_abnormal_smooth_muscle0.81343824
143MP0002925_abnormal_cardiovascular_devel0.81232538
144MP0008877_abnormal_DNA_methylation0.81116398
145MP0002132_abnormal_respiratory_system0.81029106
146MP0001853_heart_inflammation0.80992389
147MP0005551_abnormal_eye_electrophysiolog0.80207504
148MP0000639_abnormal_adrenal_gland0.79987802
149MP0005647_abnormal_sex_gland0.79967966
150MP0003638_abnormal_response/metabolism_0.79696261
151MP0000343_altered_response_to0.78342241
152MP0002876_abnormal_thyroid_physiology0.77653077
153MP0009053_abnormal_anal_canal0.77428574
154MP0002693_abnormal_pancreas_physiology0.75643996
155MP0004134_abnormal_chest_morphology0.75571962
156MP0003787_abnormal_imprinting0.73135185
157MP0004019_abnormal_vitamin_homeostasis0.73010987
158MP0003091_abnormal_cell_migration0.72780323
159MP0005332_abnormal_amino_acid0.72717891
160MP0001286_abnormal_eye_development0.72358799
161MP0002928_abnormal_bile_duct0.71672027
162MP0001666_abnormal_nutrient_absorption0.70156888
163MP0002006_tumorigenesis0.69121684
164MP0001663_abnormal_digestive_system0.68628044
165MP0001440_abnormal_grooming_behavior0.68162006
166MP0003828_pulmonary_edema0.67890791
167MP0005636_abnormal_mineral_homeostasis0.66781071

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.44707933
2Eczematoid dermatitis (HP:0000976)5.10226583
3Recurrent bacterial skin infections (HP:0005406)4.75256587
4Cellulitis (HP:0100658)3.95642209
5Pendular nystagmus (HP:0012043)3.83865722
6Obstructive lung disease (HP:0006536)3.82923110
7Chronic obstructive pulmonary disease (HP:0006510)3.82923110
8Mediastinal lymphadenopathy (HP:0100721)3.78857910
9Recurrent gram-negative bacterial infections (HP:0005420)3.49831403
10Abnormality of cells of the erythroid lineage (HP:0012130)3.48850280
11Abnormal number of erythroid precursors (HP:0012131)3.48341561
12Recurrent fungal infections (HP:0002841)3.42172186
13Recurrent viral infections (HP:0004429)3.36118391
14Meningitis (HP:0001287)3.23552831
15Abnormality of the nasal septum (HP:0000419)3.16003943
16IgM deficiency (HP:0002850)3.05765289
17Abnormality of macrophages (HP:0004311)2.83401550
18Recurrent skin infections (HP:0001581)2.83348302
19Pallor (HP:0000980)2.82949197
20Chromsome breakage (HP:0040012)2.82530126
21Osteomyelitis (HP:0002754)2.82103688
22Abnormality of B cell number (HP:0010975)2.76197465
23B lymphocytopenia (HP:0010976)2.76197465
24Abnormality of the middle phalanges of the toes (HP:0010183)2.71095040
25Absent rod-and cone-mediated responses on ERG (HP:0007688)2.70746563
26Abnormality of DNA repair (HP:0003254)2.66980734
27Short femoral neck (HP:0100864)2.62831995
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62317529
29Abolished electroretinogram (ERG) (HP:0000550)2.60317640
30Agammaglobulinemia (HP:0004432)2.59091707
31Abnormality of cochlea (HP:0000375)2.56620590
32Gingivitis (HP:0000230)2.56584486
33Inflammation of the large intestine (HP:0002037)2.55724236
34Asplenia (HP:0001746)2.53388985
35Aplasia/Hypoplasia of the spleen (HP:0010451)2.52768912
36Gastrointestinal inflammation (HP:0004386)2.52518447
37Bilateral microphthalmos (HP:0007633)2.51336602
38Reticulocytopenia (HP:0001896)2.51024840
39Spontaneous hematomas (HP:0007420)2.50283890
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.49610129
41Myositis (HP:0100614)2.48708038
42Absent thumb (HP:0009777)2.47023290
43Hyperglycinemia (HP:0002154)2.45054873
44Abnormality of the proximal phalanges of the hand (HP:0009834)2.42112727
45Osteomalacia (HP:0002749)2.41328960
46Recurrent pneumonia (HP:0006532)2.38763980
47Morphological abnormality of the middle ear (HP:0008609)2.38153577
48Humeroradial synostosis (HP:0003041)2.37697345
49Synostosis involving the elbow (HP:0003938)2.37697345
50Abnormality of the renal collecting system (HP:0004742)2.37446757
51Enlarged kidneys (HP:0000105)2.35530290
52Colitis (HP:0002583)2.34144520
53Abnormality of the phalanges of the 5th finger (HP:0004213)2.33980388
54Septo-optic dysplasia (HP:0100842)2.33869812
55Thyroiditis (HP:0100646)2.31945107
56Spinal cord lesions (HP:0100561)2.30970441
57Syringomyelia (HP:0003396)2.30970441
58Congenital stationary night blindness (HP:0007642)2.30338996
59Agitation (HP:0000713)2.30273202
60Thrombocytosis (HP:0001894)2.29829028
61Agnosia (HP:0010524)2.28773334
62Ectopic kidney (HP:0000086)2.27653092
63Sepsis (HP:0100806)2.26374693
64Verrucae (HP:0200043)2.26370405
65Papilloma (HP:0012740)2.26370405
66Diastasis recti (HP:0001540)2.26269249
67Vitreoretinal degeneration (HP:0000655)2.25327951
68Asymmetry of the thorax (HP:0001555)2.23928141
69Methylmalonic acidemia (HP:0002912)2.23579346
70Chronic mucocutaneous candidiasis (HP:0002728)2.23293298
71Recurrent cutaneous fungal infections (HP:0011370)2.23293298
72Abnormality of the fingertips (HP:0001211)2.22724540
73Porencephaly (HP:0002132)2.22123075
74Irregular epiphyses (HP:0010582)2.19294324
75Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.18829398
76Petechiae (HP:0000967)2.18753637
77Homocystinuria (HP:0002156)2.17712186
78Abnormality of homocysteine metabolism (HP:0010919)2.17712186
79Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.16296158
80Genetic anticipation (HP:0003743)2.15764315
81Vaginal fistula (HP:0004320)2.14621517
82Recurrent sinusitis (HP:0011108)2.13190139
83Recurrent bronchitis (HP:0002837)2.12524113
84Recurrent lower respiratory tract infections (HP:0002783)2.09158291
85Abnormal rod and cone electroretinograms (HP:0008323)2.09097902
86Cleft eyelid (HP:0000625)2.06180045
87Methylmalonic aciduria (HP:0012120)2.05844799
88Confusion (HP:0001289)2.05592965
89Aplasia/Hypoplasia of the patella (HP:0006498)2.05535080
90Urticaria (HP:0001025)2.04797602
91Abnormality of the phalanges of the 2nd finger (HP:0009541)2.03367784
92Abnormal platelet volume (HP:0011876)2.03051502
93Chest pain (HP:0100749)2.03041627
94Myelodysplasia (HP:0002863)2.02013263
95Rectovaginal fistula (HP:0000143)2.01989224
96Rectal fistula (HP:0100590)2.01989224
97Volvulus (HP:0002580)2.01841496
98Pancreatic cysts (HP:0001737)1.99775928
99Vasculitis (HP:0002633)1.99612850
100Prolonged bleeding time (HP:0003010)1.99269619
101IgG deficiency (HP:0004315)1.98960550
102Decreased central vision (HP:0007663)1.97446769
103Retrobulbar optic neuritis (HP:0100654)1.97332524
104Optic neuritis (HP:0100653)1.97332524
105Epiphyseal dysplasia (HP:0002656)1.97256106
106Deviation of the thumb (HP:0009603)1.96995389
107Macrocytic anemia (HP:0001972)1.96502064
108Amaurosis fugax (HP:0100576)1.95980144
109Hyperthyroidism (HP:0000836)1.95844900
110Broad alveolar ridges (HP:0000187)1.95446978
111Anophthalmia (HP:0000528)1.94711940
112Short 4th metacarpal (HP:0010044)1.93881126
113Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93881126
114Rib fusion (HP:0000902)1.91390479
115Stenosis of the external auditory canal (HP:0000402)1.90879063
116Abnormality of cells of the lymphoid lineage (HP:0012140)1.89395756
117Synostosis of carpal bones (HP:0005048)1.89055497
118Lymphopenia (HP:0001888)1.88609816
119Abnormality of chromosome stability (HP:0003220)1.88260243
120Intestinal fistula (HP:0100819)1.87838613
121Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87112651
122Panhypogammaglobulinemia (HP:0003139)1.86437318
123Short hallux (HP:0010109)1.86350209
124Leukocytosis (HP:0001974)1.85732909
125Persistence of primary teeth (HP:0006335)1.84879989
126Pancreatic fibrosis (HP:0100732)1.84082749
127Skin ulcer (HP:0200042)1.83639742
128Eosinophilia (HP:0001880)1.83574520
129Chronic otitis media (HP:0000389)1.83245341
130Abnormality of T cell physiology (HP:0011840)1.81767861
131Patellar aplasia (HP:0006443)1.81513757
132Delayed epiphyseal ossification (HP:0002663)1.79703857
133Hypoplastic pelvis (HP:0008839)1.79626099
134Hypochromic anemia (HP:0001931)1.79373093
135Disinhibition (HP:0000734)1.77173665
136Hypoplasia of the uterus (HP:0000013)1.77024599
137Morphological abnormality of the inner ear (HP:0011390)1.76865913
138Meckel diverticulum (HP:0002245)1.75995966
139Proximal placement of thumb (HP:0009623)1.75223151
140Abnormality of reticulocytes (HP:0004312)1.74902056
141Abnormal pancreas size (HP:0012094)1.74874023
142Medulloblastoma (HP:0002885)1.74108625
143High pitched voice (HP:0001620)1.73974852
144Long eyelashes (HP:0000527)1.72390360
145Deep venous thrombosis (HP:0002625)1.72238013
146IgA deficiency (HP:0002720)1.71983736
147Increased density of long bones (HP:0006392)1.71679119
148Absent frontal sinuses (HP:0002688)1.71357079
149Restlessness (HP:0000711)1.70936759
150Aplasia/Hypoplasia of the hallux (HP:0008362)1.70539190
151Lymphoma (HP:0002665)1.70317458
152Elevated erythrocyte sedimentation rate (HP:0003565)1.70316469
153Horseshoe kidney (HP:0000085)1.70256697
154Abnormality of T cells (HP:0002843)1.69874797
155Aplasia/Hypoplasia of the sternum (HP:0006714)1.69121657
156Hypoplasia of the radius (HP:0002984)1.68739403
157Hepatoblastoma (HP:0002884)1.68594248
158Severe visual impairment (HP:0001141)1.68151546
159Orchitis (HP:0100796)1.67125644
160Periodontitis (HP:0000704)1.67000372
161Hyperacusis (HP:0010780)1.66862538
162Selective tooth agenesis (HP:0001592)1.65697801
163Bicornuate uterus (HP:0000813)1.64971181
164Abnormality of the ileum (HP:0001549)1.64726136
165Clubbing of toes (HP:0100760)1.64508164
166Hypoplasia of the ulna (HP:0003022)1.64360058
167Abnormality of the lacrimal duct (HP:0011481)1.63968039
168Clumsiness (HP:0002312)1.63801069
169Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.63760770
170Tracheoesophageal fistula (HP:0002575)1.63706631
171Deep philtrum (HP:0002002)1.63328360
172Bicuspid aortic valve (HP:0001647)1.63316811
173Abnormal number of incisors (HP:0011064)1.63110318
174Aplasia/hypoplasia of the femur (HP:0005613)1.61761823
175Renal duplication (HP:0000075)1.61699847
176Prominent nose (HP:0000448)1.61196856
177Aplasia/Hypoplasia of the thymus (HP:0010515)1.60532255
178Aplasia/Hypoplasia of the uvula (HP:0010293)1.60530766
179Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60128966
180Stomatitis (HP:0010280)1.60055886
181Symphalangism affecting the phalanges of the hand (HP:0009773)1.60011375
182Viral hepatitis (HP:0006562)1.59894796
183Pustule (HP:0200039)1.59887929
184Combined immunodeficiency (HP:0005387)1.59484006
185Progressive cerebellar ataxia (HP:0002073)1.59467013
186Increased nuchal translucency (HP:0010880)1.59267631
187Sclerocornea (HP:0000647)1.58353702
188Cutaneous melanoma (HP:0012056)1.58247008
189True hermaphroditism (HP:0010459)1.57085897
190Concave nail (HP:0001598)1.56257347
191Bony spicule pigmentary retinopathy (HP:0007737)1.56134191
192Congenital, generalized hypertrichosis (HP:0004540)1.55543692

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.34751730
2BLK3.06032343
3CDK122.92251247
4MAP4K12.89577612
5WNK42.87718993
6IRAK42.60287922
7EEF2K2.59539084
8STK102.43267457
9ADRBK22.42709867
10CDC72.33333023
11GRK62.25010613
12CLK12.20542546
13TYRO32.20046131
14GRK12.11215758
15BTK2.01346286
16FGFR41.97002874
17PKN21.95180426
18PLK41.91234038
19ERN11.88078866
20FRK1.77302972
21RPS6KB21.74941168
22NME11.72799604
23CSF1R1.66058938
24NEK21.65896448
25MAP3K141.56615477
26RIPK41.55024182
27PRKD21.52889652
28TRIB31.52187211
29PIM11.44189460
30STK41.43326698
31FGFR21.43183475
32MAP3K91.40012208
33LRRK21.33384268
34ALK1.29735455
35DYRK21.29649069
36TIE11.29598895
37TRPM71.24248602
38BCKDK1.24205863
39PINK11.23206896
40STK31.23175870
41CSK1.23143150
42TLK11.18749241
43SYK1.16789254
44HCK1.16223725
45MARK31.15213495
46TAF11.14702605
47TAOK31.12325694
48TESK21.12295864
49PTK61.11246949
50PAK41.10006580
51CDK41.09686115
52MAP3K111.08821557
53MAP3K81.07165576
54SMG11.06546563
55TBK11.05981970
56CDK71.05699801
57SRPK11.04981618
58FES1.03815302
59MAP2K21.03532599
60BMPR1B1.02807515
61BRD41.02803997
62TEC1.02160704
63JAK31.02054547
64KIT1.01560571
65MAP2K31.00680372
66EPHB11.00042334
67MKNK10.99581547
68FGFR30.99348248
69MKNK20.98373191
70KDR0.97822988
71SCYL20.96325532
72TESK10.96003923
73ATR0.94912050
74ZAP700.93980899
75LYN0.91359034
76TYK20.91267521
77RPS6KA40.91140771
78BRSK20.90371632
79PRKCQ0.88052118
80STK240.86939387
81TTK0.86607711
82CDK60.85595502
83DAPK20.85470504
84LCK0.84987318
85SGK2230.82872601
86SGK4940.82872601
87DYRK1B0.81515536
88WEE10.81038807
89BMX0.79356473
90YES10.77920787
91DYRK30.75503313
92IRAK30.74729084
93CHEK10.74654220
94STK160.74557197
95FLT30.73673500
96IKBKB0.73251071
97FGR0.73005923
98PASK0.71381295
99IKBKE0.70778233
100ITK0.70247858
101EIF2AK30.69637755
102ERBB20.68905916
103PRKCZ0.67299560
104AURKB0.66242387
105CDK90.64999622
106MAP4K20.64908180
107MAPKAPK20.64691236
108INSRR0.64004616
109LATS10.63853389
110CHEK20.63544740
111SIK20.62675079
112OXSR10.62514849
113SGK10.62422971
114VRK20.61712923
115CDK190.61710414
116ACVR1B0.60980936
117TXK0.60621743
118SGK20.60439469
119ATM0.60130341
120PRKAA20.59336461
121PLK10.59268679
122TNK20.58242180
123TTN0.57938280
124CHUK0.57582283
125MAP3K70.56802992
126HIPK20.56402072
127MAP2K60.56254951
128ICK0.56146632
129NUAK10.55424371
130BRAF0.55166267
131WNK10.54752051
132GRK70.54633629
133RPS6KA20.53452000
134PRKCG0.53204999
135RPS6KA10.53172709
136MATK0.52964923
137EIF2AK10.52292155
138RPS6KL10.51891667
139RPS6KC10.51891667
140PRKG20.50812727
141RPS6KA60.50367620
142AKT10.48969148
143PLK30.48788411
144ZAK0.47846057
145TGFBR20.47794184
146CDK20.47393415
147MTOR0.46807571
148CAMK1D0.46761236
149STK110.46467242
150ABL10.44777554
151FGFR10.44497233
152BUB10.43842486
153DDR20.42872975
154VRK10.42554045
155RPS6KA50.40053454
156AURKA0.38164854

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.47637396
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.38775722
3Leishmaniasis_Homo sapiens_hsa051402.36125208
4DNA replication_Homo sapiens_hsa030302.17736179
5Vitamin digestion and absorption_Homo sapiens_hsa049772.11049107
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.10624997
7B cell receptor signaling pathway_Homo sapiens_hsa046622.06593738
8Autoimmune thyroid disease_Homo sapiens_hsa053201.91825404
9Oxidative phosphorylation_Homo sapiens_hsa001901.89434879
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.80548168
11Osteoclast differentiation_Homo sapiens_hsa043801.76091994
12Antigen processing and presentation_Homo sapiens_hsa046121.74893820
13Sulfur relay system_Homo sapiens_hsa041221.67536910
14Primary immunodeficiency_Homo sapiens_hsa053401.67446518
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.66406767
16Cell cycle_Homo sapiens_hsa041101.65263399
17Mismatch repair_Homo sapiens_hsa034301.63148654
18Base excision repair_Homo sapiens_hsa034101.60338645
19Spliceosome_Homo sapiens_hsa030401.58445067
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57508858
21Type I diabetes mellitus_Homo sapiens_hsa049401.57353390
22Phototransduction_Homo sapiens_hsa047441.55957709
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.53321433
24Fat digestion and absorption_Homo sapiens_hsa049751.50960263
25Herpes simplex infection_Homo sapiens_hsa051681.48702980
26Homologous recombination_Homo sapiens_hsa034401.43677890
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43511265
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40433238
29Basal cell carcinoma_Homo sapiens_hsa052171.39867270
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39105973
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.38998832
32Hematopoietic cell lineage_Homo sapiens_hsa046401.38571783
33Measles_Homo sapiens_hsa051621.36494142
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.35080467
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34899537
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34529024
37Non-homologous end-joining_Homo sapiens_hsa034501.34400988
38Steroid biosynthesis_Homo sapiens_hsa001001.33852091
39RNA transport_Homo sapiens_hsa030131.33790284
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33421593
41Chronic myeloid leukemia_Homo sapiens_hsa052201.32938566
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.31329062
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30926083
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30740562
45Tuberculosis_Homo sapiens_hsa051521.30297637
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29616460
47Legionellosis_Homo sapiens_hsa051341.29297475
48Fanconi anemia pathway_Homo sapiens_hsa034601.27591936
49RNA polymerase_Homo sapiens_hsa030201.27143559
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25563307
51Systemic lupus erythematosus_Homo sapiens_hsa053221.24014307
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23379452
53Asthma_Homo sapiens_hsa053101.22891964
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21810992
55Viral carcinogenesis_Homo sapiens_hsa052031.20958286
56Parkinsons disease_Homo sapiens_hsa050121.20640511
57MicroRNAs in cancer_Homo sapiens_hsa052061.20598957
58Apoptosis_Homo sapiens_hsa042101.20548459
59Acute myeloid leukemia_Homo sapiens_hsa052211.18520538
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18362325
61Epstein-Barr virus infection_Homo sapiens_hsa051691.17511166
62Shigellosis_Homo sapiens_hsa051311.17051145
63mRNA surveillance pathway_Homo sapiens_hsa030151.16165331
64Toxoplasmosis_Homo sapiens_hsa051451.13769738
65Ribosome_Homo sapiens_hsa030101.11964349
66Hepatitis B_Homo sapiens_hsa051611.11813401
67p53 signaling pathway_Homo sapiens_hsa041151.08930981
68African trypanosomiasis_Homo sapiens_hsa051431.07049124
69Allograft rejection_Homo sapiens_hsa053301.06456127
70Chemokine signaling pathway_Homo sapiens_hsa040621.05564384
71Influenza A_Homo sapiens_hsa051641.05359826
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03823229
73Type II diabetes mellitus_Homo sapiens_hsa049301.02121968
74Rheumatoid arthritis_Homo sapiens_hsa053231.01720231
75HTLV-I infection_Homo sapiens_hsa051661.01390024
76Pertussis_Homo sapiens_hsa051331.00704905
77Jak-STAT signaling pathway_Homo sapiens_hsa046301.00159845
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99466627
79Non-small cell lung cancer_Homo sapiens_hsa052230.98405097
80One carbon pool by folate_Homo sapiens_hsa006700.98281212
81Small cell lung cancer_Homo sapiens_hsa052220.98182152
82Selenocompound metabolism_Homo sapiens_hsa004500.97958588
83Salmonella infection_Homo sapiens_hsa051320.97894429
84Nucleotide excision repair_Homo sapiens_hsa034200.96641694
85Graft-versus-host disease_Homo sapiens_hsa053320.96219112
86RNA degradation_Homo sapiens_hsa030180.96140952
87T cell receptor signaling pathway_Homo sapiens_hsa046600.95916184
88Complement and coagulation cascades_Homo sapiens_hsa046100.95114980
89Pancreatic cancer_Homo sapiens_hsa052120.94945723
90Viral myocarditis_Homo sapiens_hsa054160.93791128
91Hedgehog signaling pathway_Homo sapiens_hsa043400.93442852
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93303588
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92347433
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.90851994
95Fatty acid biosynthesis_Homo sapiens_hsa000610.90535066
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90074665
97Notch signaling pathway_Homo sapiens_hsa043300.90016834
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.89695377
99Staphylococcus aureus infection_Homo sapiens_hsa051500.88519089
100Malaria_Homo sapiens_hsa051440.87880129
101Other glycan degradation_Homo sapiens_hsa005110.87655331
102Platelet activation_Homo sapiens_hsa046110.85742088
103Adherens junction_Homo sapiens_hsa045200.84907026
104TNF signaling pathway_Homo sapiens_hsa046680.81461547
105Glycerolipid metabolism_Homo sapiens_hsa005610.76713215
106Proteoglycans in cancer_Homo sapiens_hsa052050.76626441
107Renin-angiotensin system_Homo sapiens_hsa046140.76415139
108Ether lipid metabolism_Homo sapiens_hsa005650.75479369
109HIF-1 signaling pathway_Homo sapiens_hsa040660.75352564
110Phagosome_Homo sapiens_hsa041450.75050381
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74061319
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73229030
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72221692
114Prostate cancer_Homo sapiens_hsa052150.72069558
115Nitrogen metabolism_Homo sapiens_hsa009100.71831067
116Colorectal cancer_Homo sapiens_hsa052100.69673807
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69227302
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.68702696
119Huntingtons disease_Homo sapiens_hsa050160.68284148
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67068989
121Linoleic acid metabolism_Homo sapiens_hsa005910.66630023
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64490782
123Pathways in cancer_Homo sapiens_hsa052000.63364767
124VEGF signaling pathway_Homo sapiens_hsa043700.62641189
125Alzheimers disease_Homo sapiens_hsa050100.61769865
126Endometrial cancer_Homo sapiens_hsa052130.61284118
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60686223
128Nicotine addiction_Homo sapiens_hsa050330.59947088
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59157524
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57457833
131MAPK signaling pathway_Homo sapiens_hsa040100.57399182
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57325578
133Basal transcription factors_Homo sapiens_hsa030220.57154150
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57114198
135Hepatitis C_Homo sapiens_hsa051600.56528660
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55868872
137Lysosome_Homo sapiens_hsa041420.55729580
138Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54933696
139Renal cell carcinoma_Homo sapiens_hsa052110.54786732
140Cardiac muscle contraction_Homo sapiens_hsa042600.54595979
141Tryptophan metabolism_Homo sapiens_hsa003800.54548237
142mTOR signaling pathway_Homo sapiens_hsa041500.54327466
143Sulfur metabolism_Homo sapiens_hsa009200.53737696
144FoxO signaling pathway_Homo sapiens_hsa040680.52762085
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.49247754
146TGF-beta signaling pathway_Homo sapiens_hsa043500.47427013
147Thyroid cancer_Homo sapiens_hsa052160.47218892
148Melanoma_Homo sapiens_hsa052180.46789262
149Olfactory transduction_Homo sapiens_hsa047400.45050425
150Collecting duct acid secretion_Homo sapiens_hsa049660.43584576
151Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42176934
152Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35989959
153Rap1 signaling pathway_Homo sapiens_hsa040150.35756968
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.31256415
155Morphine addiction_Homo sapiens_hsa050320.29019168
156Cyanoamino acid metabolism_Homo sapiens_hsa004600.27649816
157Wnt signaling pathway_Homo sapiens_hsa043100.27285865

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