ARID3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)9.13456085
2polyketide metabolic process (GO:0030638)9.13456085
3doxorubicin metabolic process (GO:0044598)9.13456085
4protein localization to kinetochore (GO:0034501)6.27748628
5somite rostral/caudal axis specification (GO:0032525)6.11129073
6maintenance of protein location in nucleus (GO:0051457)5.99293961
7regulation of telomere maintenance via telomerase (GO:0032210)5.85041705
8regulation of nuclear cell cycle DNA replication (GO:0033262)5.80740197
9aminoglycoside antibiotic metabolic process (GO:0030647)5.79882446
10negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.68859462
11histone H4-K12 acetylation (GO:0043983)5.46640274
12negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.45981569
13histone H4-K5 acetylation (GO:0043981)5.38534067
14histone H4-K8 acetylation (GO:0043982)5.38534067
15negative regulation of epidermis development (GO:0045683)5.37657221
16regulation of mammary gland epithelial cell proliferation (GO:0033599)5.30148809
17negative regulation of telomerase activity (GO:0051974)5.25832373
18mitotic sister chromatid segregation (GO:0000070)5.18753372
19negative regulation of cell cycle G2/M phase transition (GO:1902750)5.10979337
20heterochromatin organization (GO:0070828)5.02278139
21regulation of response to osmotic stress (GO:0047484)4.98344098
22rRNA transcription (GO:0009303)4.86903136
23pre-miRNA processing (GO:0031054)4.83090814
24protein localization to chromosome, centromeric region (GO:0071459)4.81610880
25regulation of histone H3-K9 methylation (GO:0051570)4.78254978
26nuclear pore complex assembly (GO:0051292)4.74069437
27DNA replication-dependent nucleosome organization (GO:0034723)4.65043773
28DNA replication-dependent nucleosome assembly (GO:0006335)4.65043773
29regulation of MHC class I biosynthetic process (GO:0045343)4.61363391
30primitive streak formation (GO:0090009)4.56525244
31negative regulation of histone methylation (GO:0031061)4.51541084
32notochord development (GO:0030903)4.46077846
33muscle organ morphogenesis (GO:0048644)4.45483860
34sister chromatid segregation (GO:0000819)4.41468314
35positive regulation of DNA-dependent DNA replication (GO:2000105)4.38413472
36nuclear pore organization (GO:0006999)4.34133926
37DNA replication checkpoint (GO:0000076)4.30657932
38negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.28264453
39negative regulation of translation, ncRNA-mediated (GO:0040033)4.28264453
40regulation of translation, ncRNA-mediated (GO:0045974)4.28264453
41chromatin assembly (GO:0031497)4.27423334
42negative regulation of telomere maintenance (GO:0032205)4.25747546
43regulation of cilium movement (GO:0003352)4.24561332
44regulation of gene silencing by RNA (GO:0060966)4.21576618
45regulation of posttranscriptional gene silencing (GO:0060147)4.21576618
46regulation of gene silencing by miRNA (GO:0060964)4.21576618
47negative regulation of epidermal cell differentiation (GO:0045605)4.20454138
48positive regulation of SMAD protein import into nucleus (GO:0060391)4.13789092
49rRNA methylation (GO:0031167)4.12993610
50regulation of translation in response to stress (GO:0043555)4.11243250
51cytidine metabolic process (GO:0046087)4.11169110
52cytidine catabolic process (GO:0006216)4.11169110
53cytidine deamination (GO:0009972)4.11169110
54histone H4-K16 acetylation (GO:0043984)4.10091715
55paraxial mesoderm development (GO:0048339)4.02318758
56interferon-gamma production (GO:0032609)3.97409828
57L-serine metabolic process (GO:0006563)3.90120836
58rRNA modification (GO:0000154)3.86418171
59cell fate commitment involved in formation of primary germ layer (GO:0060795)3.84535327
60regulation of chromatin silencing (GO:0031935)3.74992859
61regulation of apoptotic process involved in morphogenesis (GO:1902337)3.71235247
62establishment of integrated proviral latency (GO:0075713)3.67731412
63DNA strand elongation involved in DNA replication (GO:0006271)3.66509659
64nucleosome disassembly (GO:0006337)3.65944915
65protein-DNA complex disassembly (GO:0032986)3.65944915
66chromatin remodeling at centromere (GO:0031055)3.65483986
67regulation of stem cell maintenance (GO:2000036)3.64751982
68branching involved in mammary gland duct morphogenesis (GO:0060444)3.57316228
69somatic diversification of immune receptors via somatic mutation (GO:0002566)3.56879952
70somatic hypermutation of immunoglobulin genes (GO:0016446)3.56879952
71intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.55208856
72mitotic chromosome condensation (GO:0007076)3.54707045
73pore complex assembly (GO:0046931)3.53897043
74regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.50400485
75nucleoside transmembrane transport (GO:1901642)3.50323567
76histone H3-K36 demethylation (GO:0070544)3.49858640
77regulation of DNA methylation (GO:0044030)3.48919904
78RNA stabilization (GO:0043489)3.48866852
79mRNA stabilization (GO:0048255)3.48866852
80trophectodermal cell differentiation (GO:0001829)3.48320077
81ncRNA catabolic process (GO:0034661)3.48098213
82DNA duplex unwinding (GO:0032508)3.47649644
83regulation of telomere maintenance (GO:0032204)3.47211461
84protein complex localization (GO:0031503)3.46308610
85DNA strand elongation (GO:0022616)3.44879480
86DNA geometric change (GO:0032392)3.44441538
87cullin deneddylation (GO:0010388)3.43592738
88phenol-containing compound catabolic process (GO:0019336)3.42734735
89formation of translation preinitiation complex (GO:0001731)3.39437747
90intestinal epithelial cell development (GO:0060576)3.39421679
91IMP biosynthetic process (GO:0006188)3.38829517
92DNA replication-independent nucleosome organization (GO:0034724)3.38716205
93DNA replication-independent nucleosome assembly (GO:0006336)3.38716205
94hormone catabolic process (GO:0042447)3.37887182
95histone arginine methylation (GO:0034969)3.36666343
96CENP-A containing nucleosome assembly (GO:0034080)3.36325640
97DNA replication initiation (GO:0006270)3.33967151
98DNA unwinding involved in DNA replication (GO:0006268)3.30580278
99regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.30437930
100ATP-dependent chromatin remodeling (GO:0043044)3.29138293
101signal transduction involved in regulation of gene expression (GO:0023019)3.27275496
102retinoic acid receptor signaling pathway (GO:0048384)3.25850098
103response to dietary excess (GO:0002021)3.25701668
104ribosome biogenesis (GO:0042254)3.25139240
105maintenance of protein localization in organelle (GO:0072595)3.24643243
106negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.22844274
107DNA damage response, detection of DNA damage (GO:0042769)3.22382309
108quinone metabolic process (GO:1901661)3.21172916
109regulation of telomerase activity (GO:0051972)3.20669287
110cell migration involved in gastrulation (GO:0042074)3.20317301
111regulation of cell fate specification (GO:0042659)3.19694661
112positive regulation of protein deacetylation (GO:0090312)3.19281278
113negative regulation of gene silencing (GO:0060969)3.18327292
114regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.17543979
115regulation of mitotic spindle checkpoint (GO:1903504)3.17543979
116positive regulation of gene expression, epigenetic (GO:0045815)3.13878674
117regulation of helicase activity (GO:0051095)3.11323578
118histone exchange (GO:0043486)3.09754010
119intracellular estrogen receptor signaling pathway (GO:0030520)3.07429297
120chromatin silencing (GO:0006342)3.06437713
121anterior/posterior axis specification (GO:0009948)3.04859982
122regulation of double-strand break repair (GO:2000779)3.03955965
123chromatin assembly or disassembly (GO:0006333)3.03151050
124transcription from mitochondrial promoter (GO:0006390)3.00988553
125protein deneddylation (GO:0000338)2.99355170
126protein polyglutamylation (GO:0018095)2.97732428
127microtubule severing (GO:0051013)2.97468617
128cardiovascular system development (GO:0072358)2.95590890
129IMP metabolic process (GO:0046040)2.95575665
130negative regulation of RNA splicing (GO:0033119)2.94889313
131telomere maintenance via semi-conservative replication (GO:0032201)2.93750137
132single strand break repair (GO:0000012)2.92889335
133negative regulation of chromosome segregation (GO:0051985)2.92800159
134regulation of DNA-dependent DNA replication (GO:0090329)2.92532232
135histone H3-K4 methylation (GO:0051568)2.90020601
136positive regulation of histone deacetylation (GO:0031065)2.89549531
137mitotic sister chromatid cohesion (GO:0007064)2.89280624
138apoptotic DNA fragmentation (GO:0006309)2.88603789
139negative regulation of mRNA processing (GO:0050686)2.88257176
140maternal placenta development (GO:0001893)2.87081922
141NLS-bearing protein import into nucleus (GO:0006607)2.85931513
142negative regulation of mitotic sister chromatid separation (GO:2000816)2.85492883
143negative regulation of sister chromatid segregation (GO:0033046)2.85492883
144negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85492883
145negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.85492883
146negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85492883
147regulation of gene silencing (GO:0060968)2.85463786
148DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.85129291
149spindle assembly (GO:0051225)2.84938720
150negative regulation of mRNA metabolic process (GO:1903312)2.84150931
151mitochondrion distribution (GO:0048311)2.84103451
152DNA strand renaturation (GO:0000733)2.83739524
153L-alpha-amino acid transmembrane transport (GO:1902475)2.83286315
154regulation of SMAD protein import into nucleus (GO:0060390)2.82365385
155positive regulation of histone H3-K4 methylation (GO:0051571)2.80183461
156negative regulation of DNA-dependent DNA replication (GO:2000104)2.80147322
157nucleobase biosynthetic process (GO:0046112)2.79565213
158lung-associated mesenchyme development (GO:0060484)2.79090993
159DNA methylation (GO:0006306)2.76191485
160DNA alkylation (GO:0006305)2.76191485
161positive regulation of histone methylation (GO:0031062)2.70968417
162establishment of viral latency (GO:0019043)2.70036277
163mitotic metaphase plate congression (GO:0007080)2.69116547
164purine nucleobase biosynthetic process (GO:0009113)2.68801948
165peptidyl-arginine omega-N-methylation (GO:0035247)2.68183896
166regulation of chromatin binding (GO:0035561)2.67321657
167mitotic nuclear envelope disassembly (GO:0007077)2.65509438
168positive regulation of chromosome segregation (GO:0051984)2.63800390
169ribosomal small subunit assembly (GO:0000028)2.61892422
170regulation of histone H3-K4 methylation (GO:0051569)2.60726189
171mitotic spindle checkpoint (GO:0071174)2.60161655
172mitotic G2/M transition checkpoint (GO:0044818)2.59894510
173spindle checkpoint (GO:0031577)2.59679560

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.92178226
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.92178226
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.92178226
4E2F7_22180533_ChIP-Seq_HELA_Human5.56713624
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.96503949
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.70426245
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.27933245
8NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.94753226
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.80376947
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.79883520
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.74268649
12* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.73437864
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.58546350
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43244525
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.36363432
16TCF3_18692474_ChIP-Seq_MESCs_Mouse2.36004336
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.32540756
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.32437216
19TCF3_18692474_ChIP-Seq_MEFs_Mouse2.29866560
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.22668531
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21139465
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.03565685
23MYC_19079543_ChIP-ChIP_MESCs_Mouse1.93768414
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.88448736
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.87217201
26NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.86887320
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86313615
28* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.86295928
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84822326
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83960460
31MYC_22102868_ChIP-Seq_BL_Human1.83954175
32ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.82651806
33POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.80511899
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76969465
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76523568
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.73854524
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68489281
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65182873
39POU5F1_16518401_ChIP-PET_MESCs_Mouse1.63982663
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.63903859
41NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.63557020
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59481992
43* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57963406
44* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57902554
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.56694655
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.56204793
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53026767
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51640777
49* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50997934
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.50500604
51IRF1_19129219_ChIP-ChIP_H3396_Human1.49656753
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49583581
53SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.49499652
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49242924
55SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.46829724
56* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.44378595
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.38583798
58* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.37470502
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36306790
60GATA1_26923725_Chip-Seq_HPCs_Mouse1.34673492
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33046074
62* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.32781467
63CREB1_15753290_ChIP-ChIP_HEK293T_Human1.32477654
64* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32091167
65VDR_23849224_ChIP-Seq_CD4+_Human1.30473959
66CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29237386
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28326432
68MYC_18940864_ChIP-ChIP_HL60_Human1.27543382
69* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.26897118
70* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25162825
71PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.23924686
72* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.22318926
73RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22302087
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.22065738
75* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.21845804
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20176726
77* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19606662
78EST1_17652178_ChIP-ChIP_JURKAT_Human1.19462626
79KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19415930
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16835584
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16710538
82EGR1_19374776_ChIP-ChIP_THP-1_Human1.14469782
83* NANOG_21062744_ChIP-ChIP_HESCs_Human1.13075375
84ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12381429
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11264028
86* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.10089615
87* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07676488
88FOXP3_21729870_ChIP-Seq_TREG_Human1.05724453
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05566665
90NANOG_16153702_ChIP-ChIP_HESCs_Human1.03284606
91XRN2_22483619_ChIP-Seq_HELA_Human1.03136064
92ZNF274_21170338_ChIP-Seq_K562_Hela1.02744565
93* NANOG_16518401_ChIP-PET_MESCs_Mouse1.02363998
94DCP1A_22483619_ChIP-Seq_HELA_Human1.01096311
95E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00592583
96* TCF7_22412390_ChIP-Seq_EML_Mouse0.97467980
97KDM5A_27292631_Chip-Seq_BREAST_Human0.97370440
98NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97190092
99KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96885860
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96851180
101* NCOR1_26117541_ChIP-Seq_K562_Human0.94165920
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94107842
103CIITA_25753668_ChIP-Seq_RAJI_Human0.93924387
104MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93917469
105EZH2_22144423_ChIP-Seq_EOC_Human0.93686404
106POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91531904
107ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91226937
108SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88048099
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87992278
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87992278
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87852547
112ETS1_20019798_ChIP-Seq_JURKAT_Human0.86779987
113JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.86623675
114CDX2_20551321_ChIP-Seq_CACO-2_Human0.83339512
115TTF2_22483619_ChIP-Seq_HELA_Human0.81328834
116AR_21909140_ChIP-Seq_LNCAP_Human0.79071318
117* TP53_22127205_ChIP-Seq_IMR90_Human0.78560408
118* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77741934
119YY1_22570637_ChIP-Seq_MALME-3M_Human0.76972273
120SCL_19346495_ChIP-Seq_HPC-7_Human0.76064744
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75885350
122ELK3_25401928_ChIP-Seq_HUVEC_Human0.75863360
123* KAP1_27257070_Chip-Seq_ESCs_Mouse0.75816825
124* GABP_19822575_ChIP-Seq_HepG2_Human0.75426546
125POU5F1_16153702_ChIP-ChIP_HESCs_Human0.74837706
126TBX3_20139965_ChIP-Seq_ESCs_Mouse0.74795395
127TBX3_20139965_ChIP-Seq_MESCs_Mouse0.73439590
128SOX2_16153702_ChIP-ChIP_HESCs_Human0.73228553
129* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.72409055
130* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.72069856
131PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71162215
132TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.70490885
133TFEB_21752829_ChIP-Seq_HELA_Human0.70384341

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu4.09729736
2MP0006292_abnormal_olfactory_placode4.01397096
3MP0003890_abnormal_embryonic-extraembry3.99403679
4MP0003011_delayed_dark_adaptation3.93246227
5MP0008877_abnormal_DNA_methylation3.89852106
6MP0008057_abnormal_DNA_replication3.57485891
7MP0002254_reproductive_system_inflammat3.56428378
8MP0004957_abnormal_blastocyst_morpholog3.18085991
9MP0005499_abnormal_olfactory_system2.91264242
10MP0005394_taste/olfaction_phenotype2.91264242
11MP0002653_abnormal_ependyma_morphology2.90026131
12MP0003122_maternal_imprinting2.87725082
13MP0005075_abnormal_melanosome_morpholog2.62113598
14MP0003121_genomic_imprinting2.56339195
15MP0002332_abnormal_exercise_endurance2.39656144
16MP0009672_abnormal_birth_weight2.37937140
17MP0010352_gastrointestinal_tract_polyps2.28577163
18MP0004858_abnormal_nervous_system2.27864346
19MP0003567_abnormal_fetal_cardiomyocyte2.27669800
20MP0003077_abnormal_cell_cycle2.10808906
21* MP0001672_abnormal_embryogenesis/_devel2.04172879
22* MP0005380_embryogenesis_phenotype2.04172879
23MP0010030_abnormal_orbit_morphology2.02970477
24MP0003718_maternal_effect1.98875673
25MP0005257_abnormal_intraocular_pressure1.97642994
26MP0005377_hearing/vestibular/ear_phenot1.91359853
27MP0003878_abnormal_ear_physiology1.91359853
28MP0003123_paternal_imprinting1.90092585
29MP0000678_abnormal_parathyroid_gland1.87711277
30MP0003705_abnormal_hypodermis_morpholog1.87035165
31MP0003111_abnormal_nucleus_morphology1.87032343
32MP0010094_abnormal_chromosome_stability1.86405553
33* MP0002088_abnormal_embryonic_growth/wei1.85752178
34* MP0003984_embryonic_growth_retardation1.84921830
35MP0000350_abnormal_cell_proliferation1.79687012
36MP0006035_abnormal_mitochondrial_morpho1.78619569
37MP0001293_anophthalmia1.77549719
38MP0003136_yellow_coat_color1.72538239
39MP0000566_synostosis1.72285788
40MP0002127_abnormal_cardiovascular_syste1.67447141
41MP0001188_hyperpigmentation1.62360549
42MP0004133_heterotaxia1.61707770
43MP0003119_abnormal_digestive_system1.57165099
44* MP0002085_abnormal_embryonic_tissue1.54595358
45MP0002086_abnormal_extraembryonic_tissu1.54246257
46MP0003941_abnormal_skin_development1.53572502
47MP0003938_abnormal_ear_development1.53524939
48MP0002084_abnormal_developmental_patter1.52484732
49MP0003693_abnormal_embryo_hatching1.46291303
50MP0001730_embryonic_growth_arrest1.45780672
51MP0008961_abnormal_basal_metabolism1.45645767
52MP0003183_abnormal_peptide_metabolism1.43011666
53MP0001849_ear_inflammation1.42219169
54MP0002932_abnormal_joint_morphology1.39979618
55MP0002092_abnormal_eye_morphology1.38670531
56MP0002163_abnormal_gland_morphology1.37910097
57MP0008789_abnormal_olfactory_epithelium1.37168463
58MP0002277_abnormal_respiratory_mucosa1.36931406
59MP0008932_abnormal_embryonic_tissue1.34815369
60MP0002396_abnormal_hematopoietic_system1.32955075
61MP0004197_abnormal_fetal_growth/weight/1.30037336
62MP0000049_abnormal_middle_ear1.28297418
63MP0001697_abnormal_embryo_size1.26930530
64MP0002210_abnormal_sex_determination1.25793590
65MP0009278_abnormal_bone_marrow1.23284951
66MP0008007_abnormal_cellular_replicative1.22225380
67MP0008995_early_reproductive_senescence1.18095193
68MP0000537_abnormal_urethra_morphology1.15541949
69MP0006082_CNS_inflammation1.13616976
70MP0000428_abnormal_craniofacial_morphol1.11162764
71MP0005266_abnormal_metabolism1.10496094
72MP0008058_abnormal_DNA_repair1.08079173
73MP0003283_abnormal_digestive_organ1.06707641
74* MP0002080_prenatal_lethality1.06660475
75MP0005391_vision/eye_phenotype1.06191007
76MP0000490_abnormal_crypts_of1.05635162
77MP0000762_abnormal_tongue_morphology1.05466420
78MP0000703_abnormal_thymus_morphology1.05440724
79MP0002114_abnormal_axial_skeleton1.04062224
80MP0001929_abnormal_gametogenesis1.03784112
81MP0000631_abnormal_neuroendocrine_gland1.03455546
82MP0003315_abnormal_perineum_morphology1.03027878
83* MP0000313_abnormal_cell_death1.02408484
84MP0002233_abnormal_nose_morphology1.00360637
85MP0003787_abnormal_imprinting1.00102025
86MP0001529_abnormal_vocalization0.97308641
87MP0003646_muscle_fatigue0.94576973
88* MP0000432_abnormal_head_morphology0.93680085
89* MP0003935_abnormal_craniofacial_develop0.91468454
90* MP0002925_abnormal_cardiovascular_devel0.90458868
91MP0000653_abnormal_sex_gland0.90412650
92MP0009703_decreased_birth_body0.89943019
93MP0003755_abnormal_palate_morphology0.89576335
94MP0003698_abnormal_male_reproductive0.89199090
95MP0008770_decreased_survivor_rate0.86283799
96MP0003937_abnormal_limbs/digits/tail_de0.85510926
97MP0001286_abnormal_eye_development0.85117051
98MP0002938_white_spotting0.84274400
99MP0005248_abnormal_Harderian_gland0.83247541
100MP0001348_abnormal_lacrimal_gland0.81212653
101MP0002970_abnormal_white_adipose0.81045023
102MP0002102_abnormal_ear_morphology0.80330799
103MP0001119_abnormal_female_reproductive0.80276472
104MP0010307_abnormal_tumor_latency0.80008792
105MP0001485_abnormal_pinna_reflex0.78599427
106MP0005253_abnormal_eye_physiology0.77456695
107MP0001919_abnormal_reproductive_system0.76729371
108MP0002116_abnormal_craniofacial_bone0.75430407
109MP0002089_abnormal_postnatal_growth/wei0.75388645
110MP0002751_abnormal_autonomic_nervous0.74938402
111MP0002398_abnormal_bone_marrow0.74816345
112MP0002111_abnormal_tail_morphology0.74435966
113MP0003786_premature_aging0.74091170
114MP0005076_abnormal_cell_differentiation0.71021111
115MP0005023_abnormal_wound_healing0.70248956
116MP0000689_abnormal_spleen_morphology0.69870475
117MP0002161_abnormal_fertility/fecundity0.69651869
118MP0002132_abnormal_respiratory_system0.69182292
119MP0002019_abnormal_tumor_incidence0.69142609
120MP0001346_abnormal_lacrimal_gland0.68190797
121MP0003699_abnormal_female_reproductive0.67379865
122MP0003137_abnormal_impulse_conducting0.67194453
123MP0002822_catalepsy0.67011775
124MP0002249_abnormal_larynx_morphology0.66460845
125MP0002152_abnormal_brain_morphology0.66302713
126MP0002269_muscular_atrophy0.65982776
127* MP0003861_abnormal_nervous_system0.65589496
128MP0002722_abnormal_immune_system0.65316716
129MP0002697_abnormal_eye_size0.65314060
130MP0000358_abnormal_cell_content/0.65186090
131MP0005384_cellular_phenotype0.65077852
132MP0003943_abnormal_hepatobiliary_system0.64164778
133MP0005508_abnormal_skeleton_morphology0.63019890
134MP0000750_abnormal_muscle_regeneration0.62409370
135MP0000778_abnormal_nervous_system0.62253588
136MP0004381_abnormal_hair_follicle0.61517071
137MP0004043_abnormal_pH_regulation0.61012987
138MP0002081_perinatal_lethality0.60279057
139MP0009333_abnormal_splenocyte_physiolog0.58739302
140MP0002098_abnormal_vibrissa_morphology0.56976678
141MP0001145_abnormal_male_reproductive0.56212480

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.90800212
2Hypochromic microcytic anemia (HP:0004840)5.49761730
3Rib fusion (HP:0000902)5.08135299
4Hepatoblastoma (HP:0002884)5.04157107
5Multiple enchondromatosis (HP:0005701)4.68623559
6Ependymoma (HP:0002888)4.68375871
7Abnormality of the lower motor neuron (HP:0002366)4.48776576
8Neoplasm of striated muscle (HP:0009728)3.95571161
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.92718048
10Abnormality of the labia minora (HP:0012880)3.84316283
11Colon cancer (HP:0003003)3.78105151
12Rhabdomyosarcoma (HP:0002859)3.77494093
13Nephroblastoma (Wilms tumor) (HP:0002667)3.71214881
14Rectal fistula (HP:0100590)3.45808070
15Rectovaginal fistula (HP:0000143)3.45808070
16Chromsome breakage (HP:0040012)3.44555565
17Embryonal renal neoplasm (HP:0011794)3.43028550
18Septo-optic dysplasia (HP:0100842)3.42242024
19Intestinal fistula (HP:0100819)3.34746759
20Birth length less than 3rd percentile (HP:0003561)3.32438520
21Abnormality of the astrocytes (HP:0100707)3.29271471
22Astrocytoma (HP:0009592)3.29271471
23Aplasia/Hypoplasia of the fovea (HP:0008060)3.24187066
24Hypoplasia of the fovea (HP:0007750)3.24187066
25Fused cervical vertebrae (HP:0002949)3.12533649
26Aplasia/hypoplasia of the humerus (HP:0006507)3.11973732
27Abnormal lung lobation (HP:0002101)3.10649384
28Bifid tongue (HP:0010297)3.07415037
29Ectopic kidney (HP:0000086)3.06741959
30Short humerus (HP:0005792)3.06579968
31Partial duplication of thumb phalanx (HP:0009944)2.96440605
32Vaginal fistula (HP:0004320)2.92766298
33Abnormality of the salivary glands (HP:0010286)2.90956268
34Testicular atrophy (HP:0000029)2.87629235
35Reticulocytopenia (HP:0001896)2.85513183
36Preauricular skin tag (HP:0000384)2.78570716
37Supernumerary spleens (HP:0009799)2.77913864
38Trismus (HP:0000211)2.74832723
39Meckel diverticulum (HP:0002245)2.72241936
40Amyotrophic lateral sclerosis (HP:0007354)2.71663010
41Anomalous pulmonary venous return (HP:0010772)2.70307843
42Cortical dysplasia (HP:0002539)2.67398833
43Impulsivity (HP:0100710)2.67051525
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.63763018
45Partial duplication of the phalanx of hand (HP:0009999)2.62450514
46Shawl scrotum (HP:0000049)2.61304902
47Ragged-red muscle fibers (HP:0003200)2.60716958
48Abnormality of the ileum (HP:0001549)2.59120530
49High anterior hairline (HP:0009890)2.58593620
50Neoplasm of the adrenal cortex (HP:0100641)2.56374198
51Hyperinsulinemic hypoglycemia (HP:0000825)2.55544027
52Skin tags (HP:0010609)2.55299196
53Homocystinuria (HP:0002156)2.51052365
54Abnormality of homocysteine metabolism (HP:0010919)2.51052365
55Glioma (HP:0009733)2.47629010
56Pendular nystagmus (HP:0012043)2.47380685
57Medulloblastoma (HP:0002885)2.46852641
58Abnormality of the fovea (HP:0000493)2.42260639
59Large earlobe (HP:0009748)2.41715966
60Renal duplication (HP:0000075)2.41438495
61Periauricular skin pits (HP:0100277)2.40044801
62Preauricular pit (HP:0004467)2.40044801
63Short 5th finger (HP:0009237)2.38950139
64Absent radius (HP:0003974)2.38331682
65Abnormality of chromosome segregation (HP:0002916)2.35614127
66Horseshoe kidney (HP:0000085)2.35015834
67Hypochromic anemia (HP:0001931)2.31886145
68Stenosis of the external auditory canal (HP:0000402)2.30281357
69Broad thumb (HP:0011304)2.29979801
70Abdominal situs inversus (HP:0003363)2.29489964
71Abnormality of abdominal situs (HP:0011620)2.29489964
72Abnormality of the pulmonary veins (HP:0011718)2.29412030
73Abnormality of the phalanges of the hallux (HP:0010057)2.28875862
74Generalized hypotonia (HP:0001290)2.28065114
75Aplasia/Hypoplasia of the sternum (HP:0006714)2.27020431
76Horizontal nystagmus (HP:0000666)2.26735932
77Absent forearm bone (HP:0003953)2.26247978
78Aplasia involving forearm bones (HP:0009822)2.26247978
79Vertebral fusion (HP:0002948)2.25680847
80Aplasia/Hypoplasia of the macula (HP:0008059)2.23674607
81Carpal bone hypoplasia (HP:0001498)2.22541947
82Trigonocephaly (HP:0000243)2.21744010
83Partial agenesis of the corpus callosum (HP:0001338)2.17651816
84Neoplasm of the heart (HP:0100544)2.17167705
85Abnormal cartilage morphology (HP:0002763)2.17112580
86Diastasis recti (HP:0001540)2.16372548
87Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.15695760
88Aqueductal stenosis (HP:0002410)2.15162688
89Patellar aplasia (HP:0006443)2.14140767
90Abnormality of the distal phalanx of the thumb (HP:0009617)2.14038343
91Small intestinal stenosis (HP:0012848)2.13771122
92Duodenal stenosis (HP:0100867)2.13771122
93Esophageal atresia (HP:0002032)2.13587434
94Abnormality of DNA repair (HP:0003254)2.13346315
95Abnormality of the septum pellucidum (HP:0007375)2.11356922
96Maternal diabetes (HP:0009800)2.11232840
97Hyperglycinemia (HP:0002154)2.10459067
98Abnormal hair whorl (HP:0010721)2.09296422
99Skull defect (HP:0001362)2.09205450
100Pseudobulbar signs (HP:0002200)2.08948768
101Combined immunodeficiency (HP:0005387)2.07856061
102Abnormality of the musculature of the hand (HP:0001421)2.07228195
103Hypopigmentation of the fundus (HP:0007894)2.06422363
104Chronic bronchitis (HP:0004469)2.05350916
105Absent septum pellucidum (HP:0001331)2.04487469
106Abnormal number of incisors (HP:0011064)2.04414668
107Choanal stenosis (HP:0000452)2.04315694
108Upper motor neuron abnormality (HP:0002127)2.04038336
109Anal stenosis (HP:0002025)2.03429357
110Abnormal pancreas size (HP:0012094)2.03026993
111Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02459310
112Gastrointestinal carcinoma (HP:0002672)2.02385518
113Malignant gastrointestinal tract tumors (HP:0006749)2.02385518
114Supernumerary ribs (HP:0005815)2.01864564
115Malignant neoplasm of the central nervous system (HP:0100836)2.01587156
116Abnormality of cochlea (HP:0000375)2.01577358
117Optic nerve coloboma (HP:0000588)2.01296390
118Reduced antithrombin III activity (HP:0001976)2.01146891
119Abnormality of small intestinal villus morphology (HP:0011472)1.99951000
120Villous atrophy (HP:0011473)1.99951000
121Abnormality of chromosome stability (HP:0003220)1.99674194
122Absent thumb (HP:0009777)1.99516722
123Tongue fasciculations (HP:0001308)1.98567564
124Facial cleft (HP:0002006)1.98175627
125Hypoplasia of the pons (HP:0012110)1.97937025
126Skin pits (HP:0100276)1.97594222
127Aplasia/Hypoplasia affecting the retina (HP:0008061)1.97060267
128Anophthalmia (HP:0000528)1.95099617
129Atrophy/Degeneration involving motor neurons (HP:0007373)1.94264262
130Triphalangeal thumb (HP:0001199)1.93601932
131Neoplasm of the oral cavity (HP:0100649)1.93481729
132Premature ovarian failure (HP:0008209)1.92094674
133Atresia of the external auditory canal (HP:0000413)1.90898928
134Breast aplasia (HP:0100783)1.90591085
135Progressive muscle weakness (HP:0003323)1.89779960
136Abnormality of the pubic bones (HP:0003172)1.88931140
137Duplication of thumb phalanx (HP:0009942)1.87070551
138Missing ribs (HP:0000921)1.85470155
139Supernumerary bones of the axial skeleton (HP:0009144)1.85181013
140Prominent occiput (HP:0000269)1.84662611
141Hand muscle atrophy (HP:0009130)1.84368118
142Sensory axonal neuropathy (HP:0003390)1.83822735
143Abnormality of the duodenum (HP:0002246)1.83573603
144Broad phalanges of the hand (HP:0009768)1.81913274
145Dyschromatopsia (HP:0007641)1.81705764
146Pancreatic islet-cell hyperplasia (HP:0004510)1.81660772
147Cleft eyelid (HP:0000625)1.81490572
148Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.80833316
149Aplasia/Hypoplasia of the patella (HP:0006498)1.80717597
150Abnormality of the fingertips (HP:0001211)1.80697051
151Abnormality of the preputium (HP:0100587)1.78708943
152Neonatal hypoglycemia (HP:0001998)1.78093407
153Tetraplegia (HP:0002445)1.77966713
154Abnormality of the pons (HP:0007361)1.77836376
155Glossoptosis (HP:0000162)1.77793145
156Embryonal neoplasm (HP:0002898)1.77722164
157Basal cell carcinoma (HP:0002671)1.77644656
158Intestinal atresia (HP:0011100)1.76007546
159Absent eyebrow (HP:0002223)1.74810578
160Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.74705958
161Abnormality of cells of the erythroid lineage (HP:0012130)1.72497312
162Preaxial foot polydactyly (HP:0001841)1.71260637
163Abnormality of the aortic arch (HP:0012303)1.68644036
164Broad finger (HP:0001500)1.67991135
165Gastrointestinal atresia (HP:0002589)1.67749762
166Cellular immunodeficiency (HP:0005374)1.66419939
167Myelomeningocele (HP:0002475)1.66389781
168Spastic diplegia (HP:0001264)1.65661642
169Hemivertebrae (HP:0002937)1.65229077
170Increased nuchal translucency (HP:0010880)1.64940601
171Abnormality of the clitoris (HP:0000056)1.64825824
172Protruding tongue (HP:0010808)1.63617764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.76928817
2GRK54.51056293
3ERN14.25291832
4GRK64.04789612
5GRK12.98542899
6CDK192.96515817
7TTK2.85604869
8CSF1R2.82927006
9SMG12.59031209
10ADRBK22.56520793
11TYRO32.53708200
12STK102.52461105
13TGFBR22.48672265
14PASK2.44422413
15TAF12.33903335
16ZAK2.25125211
17MAPK72.23046261
18TNIK2.16788550
19PLK42.16260865
20GRK72.06971772
21MATK1.95135068
22VRK21.90451388
23EEF2K1.88790211
24CDK71.84564113
25WNK11.79116577
26MOS1.78321051
27MAP3K101.77344869
28CAMK1D1.73297139
29STK241.62634396
30CAMK1G1.61409287
31PLK31.52956144
32FGFR21.52189702
33CHEK21.50610393
34TSSK61.50575478
35PAK41.39124323
36CDC71.37970046
37PLK11.34917901
38EPHA21.31854792
39CAMK41.29619740
40NEK21.24074236
41PRKG21.18794953
42MARK21.17179133
43NUAK11.16897794
44WNK31.13751850
45AKT31.13363812
46NME11.13023418
47HIPK21.11699866
48TRIM281.05660214
49CHEK11.05381520
50LATS21.04640040
51STK31.03977370
52STK160.99994837
53BUB10.99904243
54FGFR30.93789256
55FGFR10.93699631
56NLK0.89300182
57NTRK10.88417990
58ALK0.88229874
59FGR0.88123126
60ADRBK10.87562343
61AKT20.79949983
62FGFR40.79912432
63BRD40.77438757
64MTOR0.77353474
65BRAF0.77352027
66ACVR1B0.76627512
67VRK10.74675130
68MAP3K40.74578613
69CSNK1G10.74495578
70CSK0.74261289
71RPS6KB20.73844700
72STK38L0.73754699
73ICK0.73688769
74MARK30.73522940
75WEE10.73485712
76STK110.72897295
77KDR0.72783315
78BRSK20.66892580
79MAP2K60.66365655
80CDK20.66130708
81CDK40.64986941
82SRPK10.63847645
83MAP2K40.63202805
84BTK0.61285763
85CSNK1G20.59589552
86IRAK40.58782393
87AURKA0.57355971
88ATM0.57125086
89CSNK1G30.56112181
90EIF2AK20.55415524
91AURKB0.53575872
92ITK0.53345050
93MAP3K70.52394864
94PRKCI0.51025376
95RPS6KA10.50436066
96OXSR10.48591041
97YES10.47922311
98BCR0.47002373
99DYRK30.46417309
100CSNK1A1L0.46090633
101CLK10.45049042
102MAPK120.44951387
103ATR0.44915653
104TESK20.44874735
105PRKDC0.43798617
106TEC0.43530863
107BMPR1B0.42503191
108FES0.41618434
109PNCK0.40547964
110CDK10.40217956
111PAK10.40100870
112CSNK1E0.38154765
113EGFR0.38011216
114PTK20.37596818
115NEK10.37444412
116RPS6KA60.36859141
117IRAK20.36134847
118MELK0.34093618
119RPS6KL10.33570543
120RPS6KC10.33570543
121TXK0.33394340
122STK40.32470953
123PRKCQ0.32359626
124CSNK2A20.32341339
125RIPK40.31876424
126PRKD20.30942257
127MAPK100.30620119
128ERBB20.29698130
129IKBKB0.29681602
130IGF1R0.29418129
131DYRK20.29283234
132MAP4K10.29138241
133MAP3K80.29018125
134MAPK140.28211075
135RIPK10.27940726
136GSK3B0.27607081
137TAOK20.27592211
138MAPK10.27439655
139PDGFRA0.23769039
140MAP3K90.22379537
141PRKCD0.22335809
142CHUK0.22047254
143INSR0.21617762
144DYRK1A0.21602327
145SIK20.19455503
146PIM10.19378026
147DYRK1B0.17962647
148MKNK20.17700479
149AKT10.17196293
150STK380.17049623
151PRPF4B0.16401664
152PRKAA10.16293170
153BMX0.16251316
154CDK80.12397601
155CDK11A0.11189919
156LATS10.10888683
157CDK150.10218775
158PRKACB0.09987428
159MKNK10.09895695

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.00231894
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.82793218
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.34753821
4Fructose and mannose metabolism_Homo sapiens_hsa000513.27383347
5RNA transport_Homo sapiens_hsa030132.66159956
6DNA replication_Homo sapiens_hsa030302.45025242
7Mismatch repair_Homo sapiens_hsa034302.34233025
8mRNA surveillance pathway_Homo sapiens_hsa030152.18730117
9Galactose metabolism_Homo sapiens_hsa000522.16337350
10Fanconi anemia pathway_Homo sapiens_hsa034602.05609203
11Spliceosome_Homo sapiens_hsa030402.00117585
12Cell cycle_Homo sapiens_hsa041101.99179034
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.92795785
14Arachidonic acid metabolism_Homo sapiens_hsa005901.87569120
15Cysteine and methionine metabolism_Homo sapiens_hsa002701.82102269
16One carbon pool by folate_Homo sapiens_hsa006701.79560999
17Homologous recombination_Homo sapiens_hsa034401.79247161
18Base excision repair_Homo sapiens_hsa034101.75609880
19RNA degradation_Homo sapiens_hsa030181.64430722
20mTOR signaling pathway_Homo sapiens_hsa041501.62631341
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.60347257
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.53109503
23Linoleic acid metabolism_Homo sapiens_hsa005911.49587762
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.48159986
25Thyroid cancer_Homo sapiens_hsa052161.47809254
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41471161
27Ribosome_Homo sapiens_hsa030101.39194148
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.35550875
29Basal cell carcinoma_Homo sapiens_hsa052171.35094384
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32804230
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.32267181
32Steroid biosynthesis_Homo sapiens_hsa001001.30893530
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26146305
34p53 signaling pathway_Homo sapiens_hsa041151.14591332
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13695290
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13687578
37RNA polymerase_Homo sapiens_hsa030201.11434925
38Hedgehog signaling pathway_Homo sapiens_hsa043401.11314157
39Basal transcription factors_Homo sapiens_hsa030221.11081946
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10499889
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10485944
42MicroRNAs in cancer_Homo sapiens_hsa052061.02548712
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99113104
44Notch signaling pathway_Homo sapiens_hsa043300.98866977
45Nucleotide excision repair_Homo sapiens_hsa034200.97892208
46Non-homologous end-joining_Homo sapiens_hsa034500.96355515
47Hippo signaling pathway_Homo sapiens_hsa043900.93160504
48Herpes simplex infection_Homo sapiens_hsa051680.93008732
49Purine metabolism_Homo sapiens_hsa002300.92429535
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88064656
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.87180169
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86310797
53Proteasome_Homo sapiens_hsa030500.85599779
54Epstein-Barr virus infection_Homo sapiens_hsa051690.84911399
55Pathways in cancer_Homo sapiens_hsa052000.84650975
56Primary immunodeficiency_Homo sapiens_hsa053400.82621083
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82309738
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82003543
59Acute myeloid leukemia_Homo sapiens_hsa052210.79321882
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79191722
61Inositol phosphate metabolism_Homo sapiens_hsa005620.77292028
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.76888169
63Endometrial cancer_Homo sapiens_hsa052130.76754414
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74272763
65Other glycan degradation_Homo sapiens_hsa005110.73232913
66Prostate cancer_Homo sapiens_hsa052150.73163889
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73046695
68Pentose phosphate pathway_Homo sapiens_hsa000300.71576845
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.66629451
70HTLV-I infection_Homo sapiens_hsa051660.65202218
71Pyrimidine metabolism_Homo sapiens_hsa002400.64597563
72Wnt signaling pathway_Homo sapiens_hsa043100.63750295
73Adherens junction_Homo sapiens_hsa045200.61394996
74Non-small cell lung cancer_Homo sapiens_hsa052230.59397667
75Biosynthesis of amino acids_Homo sapiens_hsa012300.58112787
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57257594
77Rap1 signaling pathway_Homo sapiens_hsa040150.56731923
78Lysine degradation_Homo sapiens_hsa003100.54193620
79Vitamin digestion and absorption_Homo sapiens_hsa049770.52109582
80Bladder cancer_Homo sapiens_hsa052190.52103215
81Phototransduction_Homo sapiens_hsa047440.51579241
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.49193209
83Colorectal cancer_Homo sapiens_hsa052100.48838575
84Apoptosis_Homo sapiens_hsa042100.48039946
85Choline metabolism in cancer_Homo sapiens_hsa052310.47617476
86Viral carcinogenesis_Homo sapiens_hsa052030.45940818
87Folate biosynthesis_Homo sapiens_hsa007900.44509439
88Proteoglycans in cancer_Homo sapiens_hsa052050.44063436
89Ether lipid metabolism_Homo sapiens_hsa005650.44043443
90Oocyte meiosis_Homo sapiens_hsa041140.43096123
91Sulfur relay system_Homo sapiens_hsa041220.43071688
92Huntingtons disease_Homo sapiens_hsa050160.42948991
93Ovarian steroidogenesis_Homo sapiens_hsa049130.42534271
94B cell receptor signaling pathway_Homo sapiens_hsa046620.42306783
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.41646342
96Chronic myeloid leukemia_Homo sapiens_hsa052200.41238288
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40947884
98Long-term depression_Homo sapiens_hsa047300.40020292
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39953485
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39802137
101AMPK signaling pathway_Homo sapiens_hsa041520.38408653
102T cell receptor signaling pathway_Homo sapiens_hsa046600.36941526
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36407309
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.34978786
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34347113
106Pancreatic cancer_Homo sapiens_hsa052120.34029581
107Selenocompound metabolism_Homo sapiens_hsa004500.33942902
108Tight junction_Homo sapiens_hsa045300.33744764
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33182430
110TGF-beta signaling pathway_Homo sapiens_hsa043500.32781443
111Small cell lung cancer_Homo sapiens_hsa052220.32137249
112Regulation of autophagy_Homo sapiens_hsa041400.30835283
113VEGF signaling pathway_Homo sapiens_hsa043700.30433650
114Axon guidance_Homo sapiens_hsa043600.30391738
115Carbon metabolism_Homo sapiens_hsa012000.30381439
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29862714
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29513395
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.28786396
119Chemokine signaling pathway_Homo sapiens_hsa040620.27704501
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.26658961
121Chemical carcinogenesis_Homo sapiens_hsa052040.25797139
122Measles_Homo sapiens_hsa051620.24315099
123Antigen processing and presentation_Homo sapiens_hsa046120.24216375
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23985560
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23938633
126ErbB signaling pathway_Homo sapiens_hsa040120.22633391
127FoxO signaling pathway_Homo sapiens_hsa040680.22132859
128MAPK signaling pathway_Homo sapiens_hsa040100.22000891
129Hepatitis B_Homo sapiens_hsa051610.21094192
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20281240
131Melanogenesis_Homo sapiens_hsa049160.18498659
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16959534
133Alcoholism_Homo sapiens_hsa050340.16019624
134Ras signaling pathway_Homo sapiens_hsa040140.15764205
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.14426447
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14264054
137Melanoma_Homo sapiens_hsa052180.13178565

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