ARID5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.35451927
2regulation of gamma-delta T cell differentiation (GO:0045586)5.24083271
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.18697297
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.18697297
5regulation of gamma-delta T cell activation (GO:0046643)5.17980574
6antigen processing and presentation of endogenous antigen (GO:0019883)4.84168735
7positive thymic T cell selection (GO:0045059)4.60672136
8regulation of interleukin-12 biosynthetic process (GO:0045075)4.47712826
9response to interleukin-15 (GO:0070672)4.47470937
10interferon-gamma production (GO:0032609)4.44621723
11negative T cell selection (GO:0043383)4.42365964
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.32463247
13negative thymic T cell selection (GO:0045060)4.30601891
14tolerance induction (GO:0002507)4.30414575
15T cell migration (GO:0072678)4.29377989
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.27805880
17NIK/NF-kappaB signaling (GO:0038061)4.26534476
18positive T cell selection (GO:0043368)4.17638945
19cellular response to interleukin-15 (GO:0071350)4.15838984
20negative regulation of interleukin-12 production (GO:0032695)4.13680493
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.06256769
22response to type I interferon (GO:0034340)4.05248739
23type I interferon signaling pathway (GO:0060337)4.02947246
24cellular response to type I interferon (GO:0071357)4.02947246
25T cell selection (GO:0045058)3.96194352
26thymic T cell selection (GO:0045061)3.95112290
27response to peptidoglycan (GO:0032494)3.88419192
28regulation of B cell receptor signaling pathway (GO:0050855)3.85309327
29response to muramyl dipeptide (GO:0032495)3.82685574
30negative regulation of cell killing (GO:0031342)3.73637243
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.73637243
32leukocyte aggregation (GO:0070486)3.73144994
33regulation of T-helper 1 cell differentiation (GO:0045625)3.64781160
34regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.61952042
35myeloid dendritic cell activation (GO:0001773)3.59934396
36regulation of dendritic cell antigen processing and presentation (GO:0002604)3.56285928
37interferon-gamma-mediated signaling pathway (GO:0060333)3.55497056
38JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.54208678
39negative regulation of erythrocyte differentiation (GO:0045647)3.53791888
40macrophage activation involved in immune response (GO:0002281)3.52840533
41myeloid dendritic cell differentiation (GO:0043011)3.45482788
42regulation of chronic inflammatory response (GO:0002676)3.42304290
43positive regulation of B cell differentiation (GO:0045579)3.36436618
44B cell receptor signaling pathway (GO:0050853)3.34549154
45regulation of alpha-beta T cell proliferation (GO:0046640)3.33017492
46negative regulation of cytokine production involved in immune response (GO:0002719)3.31975048
47positive regulation of interleukin-2 production (GO:0032743)3.30356275
48detection of other organism (GO:0098543)3.29122180
49lipopolysaccharide-mediated signaling pathway (GO:0031663)3.28707525
50detection of bacterium (GO:0016045)3.28250013
51CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.25275933
52defense response to protozoan (GO:0042832)3.23772579
53response to protozoan (GO:0001562)3.23254891
54negative regulation of T cell mediated immunity (GO:0002710)3.22453610
55regulation of interleukin-2 biosynthetic process (GO:0045076)3.21433335
56regulation of B cell differentiation (GO:0045577)3.20457901
57regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.19227952
58regulation of response to interferon-gamma (GO:0060330)3.15108885
59germinal center formation (GO:0002467)3.14477884
60T cell receptor signaling pathway (GO:0050852)3.13347833
61antigen receptor-mediated signaling pathway (GO:0050851)3.13009017
62positive regulation of isotype switching (GO:0045830)3.12807974
63negative regulation of innate immune response (GO:0045824)3.10993925
64neutrophil activation involved in immune response (GO:0002283)3.10524648
65regulation of T cell tolerance induction (GO:0002664)3.10117900
66regulation of type I interferon-mediated signaling pathway (GO:0060338)3.09980046
67positive regulation of natural killer cell differentiation (GO:0032825)3.09621003
68negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.09437892
69regulation of interferon-alpha production (GO:0032647)3.08523694
70regulation of vitamin D biosynthetic process (GO:0060556)3.07956623
71regulation of T cell receptor signaling pathway (GO:0050856)3.07570099
72immunoglobulin mediated immune response (GO:0016064)3.06531443
73regulation of interferon-beta biosynthetic process (GO:0045357)3.06303475
74regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.06189409
75regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.05347090
76natural killer cell activation (GO:0030101)3.03875911
77mature B cell differentiation (GO:0002335)3.03569273
78positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.98204862
79regulation of antigen processing and presentation (GO:0002577)2.98171704
80positive regulation of humoral immune response (GO:0002922)2.96840853
81regulation of regulatory T cell differentiation (GO:0045589)2.96184441
82lymphocyte homeostasis (GO:0002260)2.94562792
83positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.92009139
84negative regulation of lymphocyte mediated immunity (GO:0002707)2.91975700
85T cell homeostasis (GO:0043029)2.91252774
86lymphocyte migration (GO:0072676)2.90866228
87regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.90339460
88alpha-beta T cell activation (GO:0046631)2.90315984
89mast cell activation (GO:0045576)2.90290693
90negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.89378836
91CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.88599936
92T-helper cell differentiation (GO:0042093)2.88599936
93positive regulation of macrophage differentiation (GO:0045651)2.88359373
94regulation of tolerance induction (GO:0002643)2.87408055
95positive regulation of interferon-alpha production (GO:0032727)2.86487493
96positive regulation of DNA recombination (GO:0045911)2.86426399
97T-helper 1 type immune response (GO:0042088)2.85686381
98positive regulation by symbiont of host defense response (GO:0052509)2.84960848
99modulation by symbiont of host defense response (GO:0052031)2.84960848
100modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.84960848
101modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.84960848
102positive regulation by organism of defense response of other organism involved in symbiotic interact2.84960848
103modulation by symbiont of host immune response (GO:0052553)2.84960848
104positive regulation of B cell activation (GO:0050871)2.84355663
105dendritic cell differentiation (GO:0097028)2.82676709
106B cell mediated immunity (GO:0019724)2.81919601
107mature B cell differentiation involved in immune response (GO:0002313)2.81262742
108neutrophil activation (GO:0042119)2.81234442
109tyrosine phosphorylation of STAT protein (GO:0007260)2.81057179
110cellular response to interferon-beta (GO:0035458)2.80953980
111regulation of isotype switching to IgG isotypes (GO:0048302)2.80880948
112T cell lineage commitment (GO:0002360)2.80736917
113positive regulation of B cell mediated immunity (GO:0002714)2.80686420
114positive regulation of immunoglobulin mediated immune response (GO:0002891)2.80686420
115natural killer cell differentiation (GO:0001779)2.79990856
116positive regulation of alpha-beta T cell proliferation (GO:0046641)2.79443134
117negative regulation of leukocyte mediated immunity (GO:0002704)2.78942420
118B cell homeostasis (GO:0001782)2.78550136
119regulation of interleukin-2 production (GO:0032663)2.78481036
120alpha-beta T cell differentiation (GO:0046632)2.78306207
121regulation of natural killer cell mediated immunity (GO:0002715)2.78290379
122regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.78290379
123positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.77816371
124lymphocyte chemotaxis (GO:0048247)2.77715315
125positive regulation of type 2 immune response (GO:0002830)2.75865677
126detection of external biotic stimulus (GO:0098581)2.75645085
127leukocyte cell-cell adhesion (GO:0007159)2.75040026
128T cell costimulation (GO:0031295)2.74599253
129positive regulation of antigen processing and presentation (GO:0002579)2.73854345
130myeloid cell activation involved in immune response (GO:0002275)2.73611744
131regulation of interleukin-12 production (GO:0032655)2.72601376
132T cell differentiation (GO:0030217)2.72538043
133T cell differentiation involved in immune response (GO:0002292)2.72517507
134alpha-beta T cell activation involved in immune response (GO:0002287)2.72517507
135regulation of RIG-I signaling pathway (GO:0039535)2.72239490
136JAK-STAT cascade (GO:0007259)2.70627647
137lymphocyte costimulation (GO:0031294)2.69769391
138positive regulation of B cell proliferation (GO:0030890)2.69420400
139cellular extravasation (GO:0045123)2.64524482
140regulation of alpha-beta T cell activation (GO:0046634)2.62159841
141lymph node development (GO:0048535)2.61775142

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.91804727
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.52665818
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.51969364
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.17613763
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.93280334
6* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.80966726
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.76740545
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.74178914
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.53826068
10* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.29955384
11RUNX_20019798_ChIP-Seq_JUKART_Human3.18092422
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.13438490
13* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.12388233
14E2F7_22180533_ChIP-Seq_HELA_Human2.99552725
15* MYB_26560356_Chip-Seq_TH2_Human2.86732765
16* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.86648768
17* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.84486790
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.80174432
19MYC_22102868_ChIP-Seq_BL_Human2.76986701
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76238596
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.68031129
22MAF_26560356_Chip-Seq_TH1_Human2.59236661
23* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55136861
24MYB_26560356_Chip-Seq_TH1_Human2.48035627
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40868780
26SCL_19346495_ChIP-Seq_HPC-7_Human2.40589390
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.34670595
28VDR_21846776_ChIP-Seq_THP-1_Human2.31628499
29* UTX_26944678_Chip-Seq_JUKART_Human2.04435474
30VDR_24763502_ChIP-Seq_THP-1_Human2.04291725
31* TCF7_22412390_ChIP-Seq_EML_Mouse1.92312405
32* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90752894
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.89928763
34* RUNX1_22412390_ChIP-Seq_EML_Mouse1.89620655
35* SPI1_23547873_ChIP-Seq_NB4_Human1.85168288
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83120160
37* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80342539
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.75872686
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69159416
40* LXR_22292898_ChIP-Seq_THP-1_Human1.68968070
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.68075516
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.67587394
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63879091
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62274953
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62037173
46MAF_26560356_Chip-Seq_TH2_Human1.57154994
47* GATA3_27048872_Chip-Seq_THYMUS_Human1.55840493
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52608622
49* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50820993
50* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44546859
51* PU_27001747_Chip-Seq_BMDM_Mouse1.39099514
52SPI1_23127762_ChIP-Seq_K562_Human1.35759180
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34134027
54* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33701416
55* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33627811
56* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30484252
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29530811
58* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28062207
59* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27341021
60PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24299509
61* KDM2B_26808549_Chip-Seq_DND41_Human1.22440454
62* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21071437
63VDR_24787735_ChIP-Seq_THP-1_Human1.16975957
64* ELK3_25401928_ChIP-Seq_HUVEC_Human1.16709320
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16704156
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15893871
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15863917
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15109458
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14433035
70GATA1_19941826_ChIP-Seq_K562_Human1.14070131
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13848131
72BCL6_27268052_Chip-Seq_Bcells_Human1.11874006
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09358694
74BCOR_27268052_Chip-Seq_Bcells_Human1.07700209
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07574813
76GATA3_26560356_Chip-Seq_TH2_Human1.06894276
77GATA1_22025678_ChIP-Seq_K562_Human1.06846813
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.04320790
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03022371
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.03009805
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02763846
82RACK7_27058665_Chip-Seq_MCF-7_Human1.02360164
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02079104
84* SA1_27219007_Chip-Seq_ERYTHROID_Human1.00328337
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97588737
86* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97381149
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96143894
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91606921
89RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91266157
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89616913
91TP63_19390658_ChIP-ChIP_HaCaT_Human0.89225747
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87357540
93SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87334048
94P68_20966046_ChIP-Seq_HELA_Human0.87157033
95* KDM2B_26808549_Chip-Seq_K562_Human0.86127102
96* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85698358
97* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85698358
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84873140
99CIITA_25753668_ChIP-Seq_RAJI_Human0.84327128
100CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82920151
101* KDM2B_26808549_Chip-Seq_JURKAT_Human0.81801790
102FOXM1_23109430_ChIP-Seq_U2OS_Human0.78769548
103ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78599720
104PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77640674
105GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75425415
106* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.75417798
107CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73723798
108SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73284738
109NCOR1_26117541_ChIP-Seq_K562_Human0.72566198
110* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.72545886
111* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71748786
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71353317
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.70797003
114HIF1A_21447827_ChIP-Seq_MCF-7_Human0.67930985
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.67374151
116EGR1_19032775_ChIP-ChIP_M12_Human0.67314016
117SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.63819742

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.69116191
2MP0001835_abnormal_antigen_presentation3.65256298
3MP0000685_abnormal_immune_system3.35487019
4MP0001790_abnormal_immune_system3.22668981
5MP0005387_immune_system_phenotype3.22668981
6MP0001800_abnormal_humoral_immune3.10746724
7MP0005671_abnormal_response_to3.01698968
8MP0003436_decreased_susceptibility_to2.95240585
9MP0009785_altered_susceptibility_to2.93468890
10MP0005000_abnormal_immune_tolerance2.87080939
11MP0003724_increased_susceptibility_to2.77080253
12MP0002452_abnormal_antigen_presenting2.69397715
13MP0004510_myositis2.69146320
14MP0002723_abnormal_immune_serum2.65914032
15MP0002420_abnormal_adaptive_immunity2.53748932
16MP0001819_abnormal_immune_cell2.51696849
17MP0002148_abnormal_hypersensitivity_rea2.49168173
18MP0005025_abnormal_response_to2.44808839
19MP0002166_altered_tumor_susceptibility2.37708131
20MP0002396_abnormal_hematopoietic_system2.36822241
21MP0002405_respiratory_system_inflammati2.35287776
22MP0002398_abnormal_bone_marrow2.30226875
23MP0001853_heart_inflammation2.28038032
24MP0003303_peritoneal_inflammation2.24483500
25MP0002419_abnormal_innate_immunity2.18805550
26MP0010155_abnormal_intestine_physiology2.17506922
27MP0000716_abnormal_immune_system2.09541080
28MP0002006_tumorigenesis2.06208649
29MP0004947_skin_inflammation2.03952364
30MP0004808_abnormal_hematopoietic_stem2.02525955
31MP0005058_abnormal_lysosome_morphology2.02472918
32MP0003300_gastrointestinal_ulcer1.97890769
33MP0009278_abnormal_bone_marrow1.89798015
34MP0000689_abnormal_spleen_morphology1.86548521
35MP0000703_abnormal_thymus_morphology1.86186425
36MP0001873_stomach_inflammation1.85781582
37MP0009333_abnormal_splenocyte_physiolog1.85537091
38MP0002722_abnormal_immune_system1.84593283
39MP0006082_CNS_inflammation1.83634221
40MP0009840_abnormal_foam_cell1.82392237
41MP0003866_abnormal_defecation1.78542483
42MP0002254_reproductive_system_inflammat1.75087043
43MP0005451_abnormal_body_composition1.72715980
44MP0003172_abnormal_lysosome_physiology1.69702048
45MP0002429_abnormal_blood_cell1.68469544
46MP0002933_joint_inflammation1.65578694
47MP0001845_abnormal_inflammatory_respons1.65321347
48MP0005397_hematopoietic_system_phenotyp1.61891482
49MP0001545_abnormal_hematopoietic_system1.61891482
50MP0004381_abnormal_hair_follicle1.47314378
51MP0005464_abnormal_platelet_physiology1.46164767
52MP0001533_abnormal_skeleton_physiology1.44508123
53MP0001851_eye_inflammation1.41515982
54MP0003828_pulmonary_edema1.40935396
55MP0003075_altered_response_to1.40087124
56MP0008007_abnormal_cellular_replicative1.36077290
57MP0003191_abnormal_cellular_cholesterol1.34438241
58MP0005310_abnormal_salivary_gland1.33229024
59MP0003448_altered_tumor_morphology1.31410408
60MP0000858_altered_metastatic_potential1.22962273
61MP0000490_abnormal_crypts_of1.18459323
62MP0008260_abnormal_autophagy1.17660881
63MP0008004_abnormal_stomach_pH1.13900550
64MP0010352_gastrointestinal_tract_polyps1.12421533
65MP0005174_abnormal_tail_pigmentation1.10294851
66MP0000465_gastrointestinal_hemorrhage1.09028980
67MP0000604_amyloidosis1.08435973
68MP0002998_abnormal_bone_remodeling1.08004260
69MP0008469_abnormal_protein_level1.02059535
70MP0000015_abnormal_ear_pigmentation1.01351161
71MP0008058_abnormal_DNA_repair1.00085023
72MP0008057_abnormal_DNA_replication0.93319051
73MP0009764_decreased_sensitivity_to0.93285433
74MP0002009_preneoplasia0.91931870
75MP0005390_skeleton_phenotype0.91103674
76MP0002019_abnormal_tumor_incidence0.89990548
77MP0001663_abnormal_digestive_system0.88056692
78MP0005075_abnormal_melanosome_morpholog0.86939688
79MP0003045_fibrosis0.86822287
80MP0003453_abnormal_keratinocyte_physiol0.85874898
81MP0002277_abnormal_respiratory_mucosa0.85370101
82MP0003656_abnormal_erythrocyte_physiolo0.83849203
83MP0005167_abnormal_blood-brain_barrier0.82867526
84MP0002132_abnormal_respiratory_system0.82630754
85MP0002138_abnormal_hepatobiliary_system0.82535782
86MP0005023_abnormal_wound_healing0.80254057
87MP0003786_premature_aging0.78764082
88MP0004883_abnormal_blood_vessel0.77862952
89MP0005076_abnormal_cell_differentiation0.76380735
90MP0005164_abnormal_response_to0.74638140
91MP0002332_abnormal_exercise_endurance0.72861934
92MP0000343_altered_response_to0.71681489
93MP0002095_abnormal_skin_pigmentation0.70841017
94MP0001216_abnormal_epidermal_layer0.70132308
95MP0003690_abnormal_glial_cell0.70076208
96MP0003091_abnormal_cell_migration0.69079517
97MP0009765_abnormal_xenobiotic_induced0.68311040
98MP0003279_aneurysm0.68239778
99MP0008961_abnormal_basal_metabolism0.66866214
100MP0002139_abnormal_hepatobiliary_system0.66005034
101MP0010307_abnormal_tumor_latency0.65906819
102MP0001191_abnormal_skin_condition0.64621124
103MP0003943_abnormal_hepatobiliary_system0.64436883
104MP0003183_abnormal_peptide_metabolism0.63887883
105MP0008874_decreased_physiological_sensi0.63738955
106MP0002877_abnormal_melanocyte_morpholog0.63383000
107MP0000249_abnormal_blood_vessel0.63084600
108MP0003795_abnormal_bone_structure0.61260009
109MP0001348_abnormal_lacrimal_gland0.60777518
110MP0009763_increased_sensitivity_to0.59909669
111MP0003566_abnormal_cell_adhesion0.59625069
112MP0000569_abnormal_digit_pigmentation0.59571163
113MP0003077_abnormal_cell_cycle0.59416737
114MP0001542_abnormal_bone_strength0.58364677
115MP0002060_abnormal_skin_morphology0.58292907
116MP0010094_abnormal_chromosome_stability0.58228315
117MP0008995_early_reproductive_senescence0.57224087
118MP0000609_abnormal_liver_physiology0.56172662
119MP0005666_abnormal_adipose_tissue0.55358868
120MP0001879_abnormal_lymphatic_vessel0.54519696
121MP0000767_abnormal_smooth_muscle0.53609255
122MP0005535_abnormal_body_temperature0.52404385
123MP0001243_abnormal_dermal_layer0.52057254
124MP0005381_digestive/alimentary_phenotyp0.51070487
125MP0000383_abnormal_hair_follicle0.50374015
126MP0005166_decreased_susceptibility_to0.49549771

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.15347351
2Myositis (HP:0100614)4.65994343
3Eczematoid dermatitis (HP:0000976)4.42037998
4Recurrent fungal infections (HP:0002841)4.32986069
5Recurrent bronchitis (HP:0002837)4.32724960
6Stomatitis (HP:0010280)4.20963551
7T lymphocytopenia (HP:0005403)4.11330788
8Recurrent viral infections (HP:0004429)4.09894524
9Abnormality of T cell number (HP:0011839)4.09859243
10Chronic otitis media (HP:0000389)4.04431074
11IgM deficiency (HP:0002850)4.00506188
12Retrobulbar optic neuritis (HP:0100654)3.85824450
13Optic neuritis (HP:0100653)3.85824450
14Orchitis (HP:0100796)3.83404472
15Recurrent abscess formation (HP:0002722)3.77365204
16Recurrent cutaneous fungal infections (HP:0011370)3.76546506
17Chronic mucocutaneous candidiasis (HP:0002728)3.76546506
18Agammaglobulinemia (HP:0004432)3.73666258
19Panhypogammaglobulinemia (HP:0003139)3.68237080
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.66939373
21Abnormality of glycolipid metabolism (HP:0010969)3.62353977
22Abnormality of liposaccharide metabolism (HP:0010968)3.62353977
23Abnormality of glycosphingolipid metabolism (HP:0004343)3.62353977
24Abnormality of T cells (HP:0002843)3.55003744
25Mediastinal lymphadenopathy (HP:0100721)3.46578515
26Abnormality of the fingertips (HP:0001211)3.45912843
27Meningitis (HP:0001287)3.39760950
28B lymphocytopenia (HP:0010976)3.37753058
29Abnormality of B cell number (HP:0010975)3.37753058
30Cellulitis (HP:0100658)3.36999619
31Inflammation of the large intestine (HP:0002037)3.32757943
32Vasculitis (HP:0002633)3.31325556
33Recurrent bacterial skin infections (HP:0005406)3.27838568
34Eosinophilia (HP:0001880)3.27038092
35Chronic diarrhea (HP:0002028)3.20453674
36Nasal polyposis (HP:0100582)3.17711859
37Severe combined immunodeficiency (HP:0004430)3.15393357
38Thyroiditis (HP:0100646)3.14628013
39Gastrointestinal inflammation (HP:0004386)3.14162479
40Systemic lupus erythematosus (HP:0002725)3.10523945
41Dysostosis multiplex (HP:0000943)3.09226635
42Increased IgE level (HP:0003212)3.05485432
43IgG deficiency (HP:0004315)3.03115117
44Chronic sinusitis (HP:0011109)3.01294836
45Abnormality of T cell physiology (HP:0011840)3.00411966
46Pulmonary infiltrates (HP:0002113)2.99090604
47Autoimmune thrombocytopenia (HP:0001973)2.98201909
48Abnormality of eosinophils (HP:0001879)2.97958748
49Spontaneous hematomas (HP:0007420)2.96079962
50Gastrointestinal infarctions (HP:0005244)2.95715679
51Abnormality of the nasal mucosa (HP:0000433)2.91144078
52Pustule (HP:0200039)2.88340180
53IgA deficiency (HP:0002720)2.86747118
54Increased cerebral lipofuscin (HP:0011813)2.84719463
55Leukocytosis (HP:0001974)2.84569128
56Recurrent skin infections (HP:0001581)2.84342799
57Colitis (HP:0002583)2.84006274
58Loss of speech (HP:0002371)2.83336958
59Granulocytopenia (HP:0001913)2.81349036
60Hemoptysis (HP:0002105)2.77833086
61Combined immunodeficiency (HP:0005387)2.73311852
62Lymphopenia (HP:0001888)2.68176026
63Keratoconjunctivitis sicca (HP:0001097)2.63805357
64Abnormality of cells of the lymphoid lineage (HP:0012140)2.61961057
65Increased IgM level (HP:0003496)2.61274189
66Recurrent sinusitis (HP:0011108)2.59039470
67Vacuolated lymphocytes (HP:0001922)2.57147778
68Obstructive lung disease (HP:0006536)2.48915191
69Chronic obstructive pulmonary disease (HP:0006510)2.48915191
70Keratoconjunctivitis (HP:0001096)2.48256685
71Thrombocytosis (HP:0001894)2.45969014
72Arterial thrombosis (HP:0004420)2.44352538
73Lymphoma (HP:0002665)2.42145829
74Urticaria (HP:0001025)2.41874740
75Increased neuronal autofluorescent lipopigment (HP:0002074)2.41648023
76Hypergammaglobulinemia (HP:0010702)2.41119329
77Osteomyelitis (HP:0002754)2.37918972
78Bronchitis (HP:0012387)2.33704475
79Cheilitis (HP:0100825)2.33053314
80Gangrene (HP:0100758)2.31954576
81Interstitial pulmonary disease (HP:0006530)2.30165235
82Encephalitis (HP:0002383)2.29566018
83Autoimmune hemolytic anemia (HP:0001890)2.28831333
84Gingivitis (HP:0000230)2.28281956
85Abnormality of macrophages (HP:0004311)2.26974728
86Gastrointestinal stroma tumor (HP:0100723)2.26307229
87Restrictive lung disease (HP:0002091)2.26148515
88Abnormality of the pleura (HP:0002103)2.25907936
89Recurrent pneumonia (HP:0006532)2.25891221
90Abnormality of mucopolysaccharide metabolism (HP:0011020)2.25089397
91Abnormality of polysaccharide metabolism (HP:0011012)2.25089397
92Abnormality of glycosaminoglycan metabolism (HP:0004371)2.25089397
93Abnormality of the prostate (HP:0008775)2.24742125
94Hematochezia (HP:0002573)2.22836563
95Emphysema (HP:0002097)2.21943471
96Pulmonary embolism (HP:0002204)2.21262805
97Lip pit (HP:0100267)2.20639081
98Increased serum ferritin (HP:0003281)2.19809573
99Purpura (HP:0000979)2.18877623
100Prolonged bleeding time (HP:0003010)2.18396024
101Premature loss of primary teeth (HP:0006323)2.18364660
102Papilloma (HP:0012740)2.17654295
103Verrucae (HP:0200043)2.17654295
104Periodontitis (HP:0000704)2.14813759
105Skin ulcer (HP:0200042)2.13625035
106Segmental peripheral demyelination/remyelination (HP:0003481)2.11088444
107Mucopolysacchariduria (HP:0008155)2.08995460
108Urinary glycosaminoglycan excretion (HP:0003541)2.08995460
109Anorexia (HP:0002039)2.08887607
110Prostate neoplasm (HP:0100787)2.08192997
111Glomerulopathy (HP:0100820)2.06446889
112Persistence of primary teeth (HP:0006335)2.05502476
113Sepsis (HP:0100806)2.04359685
114Stomach cancer (HP:0012126)2.03870985
115Hepatosplenomegaly (HP:0001433)2.02293683
116Recurrent lower respiratory tract infections (HP:0002783)2.02085015
117Joint swelling (HP:0001386)2.01880463
118Recurrent gram-negative bacterial infections (HP:0005420)1.93547204
119Epistaxis (HP:0000421)1.91570456
120Petechiae (HP:0000967)1.88209061
121Chest pain (HP:0100749)1.86189148
122Increased density of long bones (HP:0006392)1.84775801
123Gingival bleeding (HP:0000225)1.83350857
124Keratitis (HP:0000491)1.82810745
125Acute myeloid leukemia (HP:0004808)1.80910960
126Leukopenia (HP:0001882)1.78762100
127Arthralgia (HP:0002829)1.77506118

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.43379118
2TXK3.88382445
3PRPF4B3.46439293
4MAP3K143.37446302
5TYK22.94853026
6IKBKE2.75936489
7JAK32.71718658
8NLK2.65947397
9ITK2.35966216
10TEC2.26900159
11TBK12.23143053
12IRAK42.18382972
13JAK12.11515509
14EPHA32.10588593
15ZAP702.08810346
16IKBKB2.04361223
17FGFR42.03693901
18IRAK31.97849084
19MAP3K101.94944833
20STK101.90062730
21BTK1.86696068
22TAOK21.75737679
23EPHB11.70666446
24CHUK1.62431872
25SIK11.61206234
26MAP3K111.60632160
27EEF2K1.57452424
28GRK61.56884713
29FGFR31.52657178
30HCK1.52333502
31BLK1.48639593
32CDK121.48474520
33PIM11.48432311
34KIT1.42479812
35CLK11.41835776
36ERN11.41606455
37SYK1.40377372
38PIM21.40235065
39LCK1.39650340
40MST41.37670504
41TGFBR21.31356361
42TAOK11.30035194
43RPS6KA41.25231867
44TRIB31.22978015
45MAP2K31.20681510
46MATK1.18489881
47SIK31.17554246
48CSK1.16637599
49MARK31.11100558
50IRAK11.11074006
51MAP3K131.10914260
52SMG11.10761144
53GRK71.10429521
54MAP3K11.08123789
55CDC42BPA1.05915815
56FGR0.95632344
57HIPK20.95617019
58TGFBR10.95282682
59IRAK20.93651616
60TESK20.91628501
61CSF1R0.89684621
62MARK20.87549993
63ZAK0.85353099
64CAMKK10.83711174
65MAP2K20.83701731
66PASK0.83491653
67MAP3K30.82058015
68BRD40.81598655
69LYN0.81120636
70FES0.80392631
71RPS6KA50.79884894
72JAK20.74517020
73SIK20.74004022
74RIPK10.73847502
75CDK90.72032075
76RIPK40.71594052
77TAOK30.69653165
78STK40.69584892
79BMPR20.69463986
80TSSK60.67114694
81MOS0.66237111
82EIF2AK20.61376665
83RPS6KL10.61107201
84RPS6KC10.61107201
85TRPM70.60738905
86DDR20.60053409
87NME20.59477042
88PRKCQ0.59068299
89CAMKK20.55919664
90LRRK20.54710917
91PDK10.53778633
92NEK90.53344279
93FLT30.51607070
94MAPK70.51500057
95TYRO30.49100931
96MAPKAPK20.47688020
97MKNK20.46612868
98RPS6KB20.46127836
99KDR0.45925859
100STK240.45171737
101MAP2K60.44269368
102PTK60.42523091
103SGK30.42341133
104RPS6KA60.40783095
105MAPK40.39332905
106DYRK1B0.38389445
107ABL10.38382912
108CDK40.37261720
109TNK20.36649784
110MELK0.36154543
111SGK20.36062238
112PRKCH0.35693243
113RPS6KA20.35654098
114FYN0.35358862
115MAP3K50.35213256
116TLK10.34477309
117ICK0.33667828
118BMPR1B0.33351080
119RPS6KA10.33199462
120BMX0.32870942
121CDK60.32605851
122MAPK30.32352964
123MAP3K70.30203414
124EIF2AK30.29283301
125NUAK10.28855601
126MAPK150.27134559
127MAPK120.24853496
128ATR0.24378058
129CDK80.24311756
130MAPK110.23980847
131PDGFRB0.23000344
132PRKD20.22634116
133PKN10.22540292

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.76485560
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.01461088
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.96170340
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.65407787
5Measles_Homo sapiens_hsa051622.61184866
6Osteoclast differentiation_Homo sapiens_hsa043802.37507382
7Leishmaniasis_Homo sapiens_hsa051402.27006939
8T cell receptor signaling pathway_Homo sapiens_hsa046602.21483415
9Allograft rejection_Homo sapiens_hsa053302.09159643
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.07165409
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.04873388
12B cell receptor signaling pathway_Homo sapiens_hsa046622.04605554
13Graft-versus-host disease_Homo sapiens_hsa053322.00939924
14Jak-STAT signaling pathway_Homo sapiens_hsa046302.00003503
15Hematopoietic cell lineage_Homo sapiens_hsa046401.87933103
16Herpes simplex infection_Homo sapiens_hsa051681.86971724
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.84967117
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.82550872
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81847882
20Antigen processing and presentation_Homo sapiens_hsa046121.79319912
21TNF signaling pathway_Homo sapiens_hsa046681.77312047
22Influenza A_Homo sapiens_hsa051641.68938258
23Toxoplasmosis_Homo sapiens_hsa051451.64518394
24Malaria_Homo sapiens_hsa051441.63565999
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.50622622
26Hepatitis B_Homo sapiens_hsa051611.42353954
27Autoimmune thyroid disease_Homo sapiens_hsa053201.39546146
28Asthma_Homo sapiens_hsa053101.38763522
29Acute myeloid leukemia_Homo sapiens_hsa052211.36124332
30Apoptosis_Homo sapiens_hsa042101.33901819
31Legionellosis_Homo sapiens_hsa051341.31902659
32Viral myocarditis_Homo sapiens_hsa054161.30879879
33Chemokine signaling pathway_Homo sapiens_hsa040621.25007027
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24294383
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22799418
36Hepatitis C_Homo sapiens_hsa051601.19740050
37Pertussis_Homo sapiens_hsa051331.18260021
38Lysosome_Homo sapiens_hsa041421.16370793
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.15606255
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14775015
41Tuberculosis_Homo sapiens_hsa051521.13458059
42HTLV-I infection_Homo sapiens_hsa051661.10783146
43Chronic myeloid leukemia_Homo sapiens_hsa052201.07409813
44Shigellosis_Homo sapiens_hsa051311.05458903
45Prolactin signaling pathway_Homo sapiens_hsa049171.04791892
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03339961
47Epstein-Barr virus infection_Homo sapiens_hsa051691.01351015
48Glycosaminoglycan degradation_Homo sapiens_hsa005310.98910278
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96585820
50African trypanosomiasis_Homo sapiens_hsa051430.90819534
51Rheumatoid arthritis_Homo sapiens_hsa053230.89590692
52Non-homologous end-joining_Homo sapiens_hsa034500.89509798
53Viral carcinogenesis_Homo sapiens_hsa052030.88668467
54Pancreatic cancer_Homo sapiens_hsa052120.87596346
55Salmonella infection_Homo sapiens_hsa051320.86425026
56Small cell lung cancer_Homo sapiens_hsa052220.85613673
57Base excision repair_Homo sapiens_hsa034100.83450366
58Type I diabetes mellitus_Homo sapiens_hsa049400.82770763
59Staphylococcus aureus infection_Homo sapiens_hsa051500.76829562
60Prion diseases_Homo sapiens_hsa050200.72256737
61Notch signaling pathway_Homo sapiens_hsa043300.72159892
62p53 signaling pathway_Homo sapiens_hsa041150.71152317
63Platelet activation_Homo sapiens_hsa046110.70450062
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69892469
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69233432
66MicroRNAs in cancer_Homo sapiens_hsa052060.64235301
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62458265
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.62267211
69Other glycan degradation_Homo sapiens_hsa005110.59317661
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58562626
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57650723
72MAPK signaling pathway_Homo sapiens_hsa040100.57464141
73FoxO signaling pathway_Homo sapiens_hsa040680.56397894
74Prostate cancer_Homo sapiens_hsa052150.55395515
75Colorectal cancer_Homo sapiens_hsa052100.54596855
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53355296
77Bladder cancer_Homo sapiens_hsa052190.50903909
78Renal cell carcinoma_Homo sapiens_hsa052110.50580117
79DNA replication_Homo sapiens_hsa030300.50380891
80Homologous recombination_Homo sapiens_hsa034400.48474057
81Type II diabetes mellitus_Homo sapiens_hsa049300.47834381
82mTOR signaling pathway_Homo sapiens_hsa041500.47061489
83Endocytosis_Homo sapiens_hsa041440.45564453
84Pathways in cancer_Homo sapiens_hsa052000.44538092
85Fanconi anemia pathway_Homo sapiens_hsa034600.44374275
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.42959881
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41444431
88Ribosome_Homo sapiens_hsa030100.41236296
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40405978
90HIF-1 signaling pathway_Homo sapiens_hsa040660.39971119
91Insulin resistance_Homo sapiens_hsa049310.38765851
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38526908
93Endometrial cancer_Homo sapiens_hsa052130.38098471
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37449455
95VEGF signaling pathway_Homo sapiens_hsa043700.37335863
96Systemic lupus erythematosus_Homo sapiens_hsa053220.36206432
97RNA degradation_Homo sapiens_hsa030180.35949222
98Inositol phosphate metabolism_Homo sapiens_hsa005620.35671460
99Proteoglycans in cancer_Homo sapiens_hsa052050.35600079
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.35469329
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35367787
102Adherens junction_Homo sapiens_hsa045200.35241068
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35195207
104Spliceosome_Homo sapiens_hsa030400.35153463
105Non-small cell lung cancer_Homo sapiens_hsa052230.34900894
106GnRH signaling pathway_Homo sapiens_hsa049120.30547850
107Choline metabolism in cancer_Homo sapiens_hsa052310.30049406
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29749488
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29268549
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28687881
111Dorso-ventral axis formation_Homo sapiens_hsa043200.28517219
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28513069
113Mismatch repair_Homo sapiens_hsa034300.26988206
114ErbB signaling pathway_Homo sapiens_hsa040120.26075600
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.25316550
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25186487
117Focal adhesion_Homo sapiens_hsa045100.23493118
118Phagosome_Homo sapiens_hsa041450.23198139
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22745321
120Amoebiasis_Homo sapiens_hsa051460.22202482
121Insulin signaling pathway_Homo sapiens_hsa049100.20753627
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20676088

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »