ARID5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. This gene also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.51881131
2regulation of integrin activation (GO:0033623)3.49794978
3smooth muscle tissue development (GO:0048745)3.46057736
4regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.42900159
5wound healing, spreading of epidermal cells (GO:0035313)3.42136583
6cell migration involved in heart development (GO:0060973)3.38798125
7pericardium development (GO:0060039)3.37835504
8response to pheromone (GO:0019236)3.35540993
9positive regulation of protein autophosphorylation (GO:0031954)3.33471780
10negative regulation of axon extension involved in axon guidance (GO:0048843)3.32888788
11chondrocyte proliferation (GO:0035988)3.25787768
12basement membrane organization (GO:0071711)3.25659652
13regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.22097625
14regulation of integrin-mediated signaling pathway (GO:2001044)3.19627895
15desmosome organization (GO:0002934)3.19122132
16paraxial mesoderm development (GO:0048339)3.17562254
17regulation of type B pancreatic cell apoptotic process (GO:2000674)3.12980416
18negative regulation of axon guidance (GO:1902668)3.11987433
19hemidesmosome assembly (GO:0031581)3.11608406
20nuclear pore complex assembly (GO:0051292)3.11570950
21regulation of SMAD protein import into nucleus (GO:0060390)3.11228937
22positive regulation of endothelial cell apoptotic process (GO:2000353)3.06898985
23positive regulation of natural killer cell differentiation (GO:0032825)3.06246305
24notochord development (GO:0030903)3.05675016
25positive regulation of fibroblast migration (GO:0010763)3.05150186
26cell adhesion mediated by integrin (GO:0033627)3.04253596
27embryonic placenta development (GO:0001892)3.03775200
28regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.01535234
29positive regulation of SMAD protein import into nucleus (GO:0060391)3.00315009
30platelet dense granule organization (GO:0060155)2.98531447
31positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.98212433
32wound healing, spreading of cells (GO:0044319)2.95279203
33response to redox state (GO:0051775)2.94100215
34ovulation cycle (GO:0042698)2.90018659
35endodermal cell differentiation (GO:0035987)2.86139257
36collagen fibril organization (GO:0030199)2.85982739
37regulation of posttranscriptional gene silencing (GO:0060147)2.85277421
38regulation of gene silencing by miRNA (GO:0060964)2.85277421
39regulation of gene silencing by RNA (GO:0060966)2.85277421
40cellular response to interferon-alpha (GO:0035457)2.85033969
41skin morphogenesis (GO:0043589)2.82412199
42sequestering of extracellular ligand from receptor (GO:0035581)2.81872412
43negative regulation of nitric-oxide synthase activity (GO:0051001)2.78243712
44regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.77908089
45peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.74494509
46hippo signaling (GO:0035329)2.74075668
47positive regulation of cardiac muscle hypertrophy (GO:0010613)2.73815183
48positive regulation of muscle hypertrophy (GO:0014742)2.73815183
49regulation of organ formation (GO:0003156)2.71358658
50positive regulation of actin filament depolymerization (GO:0030836)2.69116973
51regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.67085770
52apoptotic cell clearance (GO:0043277)2.66183700
53craniofacial suture morphogenesis (GO:0097094)2.65984625
54nuclear pore organization (GO:0006999)2.64625714
55positive regulation of macrophage activation (GO:0043032)2.62774149
56protein K11-linked deubiquitination (GO:0035871)2.61564833
57positive regulation of p38MAPK cascade (GO:1900745)2.61409963
58regulation of tight junction assembly (GO:2000810)2.60177628
59negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.59651955
60regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.59420375
61regulation of mononuclear cell migration (GO:0071675)2.59339855
62positive regulation vascular endothelial growth factor production (GO:0010575)2.58319349
63peptidyl-glutamic acid carboxylation (GO:0017187)2.57458582
64protein carboxylation (GO:0018214)2.57458582
65regulation of muscle hypertrophy (GO:0014743)2.56381546
66embryonic forelimb morphogenesis (GO:0035115)2.56278853
67prostate gland growth (GO:0060736)2.55712971
68regulation of cardiac muscle hypertrophy (GO:0010611)2.55583554
69artery development (GO:0060840)2.54882280
70embryonic process involved in female pregnancy (GO:0060136)2.54376586
71dermatan sulfate biosynthetic process (GO:0030208)2.53344834
72embryonic cranial skeleton morphogenesis (GO:0048701)2.51468591
73negative regulation of fibrinolysis (GO:0051918)2.50968083
74response to laminar fluid shear stress (GO:0034616)2.50621161
75regulation of protein autophosphorylation (GO:0031952)2.50571157
76positive regulation of T cell chemotaxis (GO:0010820)2.50295841
77regulation of T cell chemotaxis (GO:0010819)2.50295841
78negative regulation of stress fiber assembly (GO:0051497)2.49827354
79negative regulation of chondrocyte differentiation (GO:0032331)2.49267366
80cytoplasmic mRNA processing body assembly (GO:0033962)2.48753754
81radial glial cell differentiation (GO:0060019)2.47175395
82cyclic nucleotide catabolic process (GO:0009214)2.46669631
83cell migration involved in sprouting angiogenesis (GO:0002042)2.45634724
84mesenchymal-epithelial cell signaling (GO:0060638)2.45598567
85regulation of transforming growth factor beta2 production (GO:0032909)2.45450636
86embryonic camera-type eye development (GO:0031076)2.45172317
87parental behavior (GO:0060746)2.45059185
88negative regulation of systemic arterial blood pressure (GO:0003085)2.43843825
89negative regulation of keratinocyte proliferation (GO:0010839)2.43509450
90keratan sulfate catabolic process (GO:0042340)2.43290311
91substrate adhesion-dependent cell spreading (GO:0034446)2.43236774
92mammary gland development (GO:0030879)2.42459389
93regulation of cytokine secretion involved in immune response (GO:0002739)2.41989990
94anterior/posterior axis specification, embryo (GO:0008595)2.41961392
95DNA deamination (GO:0045006)2.40700327
96atrioventricular valve morphogenesis (GO:0003181)2.40335571
97histone H2A monoubiquitination (GO:0035518)2.39510216
98intestinal epithelial cell development (GO:0060576)2.39171125
99arginine catabolic process (GO:0006527)2.39108868
100regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.38641887
101endocardial cushion development (GO:0003197)2.37676966
102positive regulation of interleukin-1 beta production (GO:0032731)2.37355118
103positive regulation of epithelial to mesenchymal transition (GO:0010718)2.37228779
104epoxygenase P450 pathway (GO:0019373)2.36569839
105cranial suture morphogenesis (GO:0060363)2.35028179
106interleukin-6-mediated signaling pathway (GO:0070102)2.33925494
107negative regulation of mast cell activation (GO:0033004)2.33542854
108blood vessel maturation (GO:0001955)2.33432978
109negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.33263963
110cytidine deamination (GO:0009972)2.32115393
111cytidine metabolic process (GO:0046087)2.32115393
112cytidine catabolic process (GO:0006216)2.32115393
113axon extension involved in axon guidance (GO:0048846)2.32034025
114neuron projection extension involved in neuron projection guidance (GO:1902284)2.32034025
115branching involved in prostate gland morphogenesis (GO:0060442)2.31499672
116retinal cone cell development (GO:0046549)2.31000599
117cell-substrate junction assembly (GO:0007044)2.30712172
118establishment of protein localization to Golgi (GO:0072600)2.30439614
119metanephros development (GO:0001656)2.30064919
120pore complex assembly (GO:0046931)2.29663677
121negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.28683439
122organ induction (GO:0001759)2.28483837
123regulation of secondary heart field cardioblast proliferation (GO:0003266)2.27697992
124regulation of cardioblast proliferation (GO:0003264)2.27697992
125regulation of T cell receptor signaling pathway (GO:0050856)2.27416277
126regulation of membrane protein ectodomain proteolysis (GO:0051043)2.27046786
127lymphangiogenesis (GO:0001946)2.26612886
128keratinocyte proliferation (GO:0043616)2.25850258
129negative regulation of T cell receptor signaling pathway (GO:0050860)2.25602414
130type B pancreatic cell proliferation (GO:0044342)2.25438467
131vagina development (GO:0060068)2.25033048
132vascular endothelial growth factor signaling pathway (GO:0038084)2.24575901
133endocrine hormone secretion (GO:0060986)2.24442860
134response to interferon-alpha (GO:0035455)2.24210168
135regulation of mitotic spindle organization (GO:0060236)2.24086739
136regulation of hippo signaling (GO:0035330)2.23665936
137* face morphogenesis (GO:0060325)2.22893229
138regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.22872514
139regulation of interleukin-8 secretion (GO:2000482)2.22640697
140regulation of vascular endothelial growth factor production (GO:0010574)2.22281360
141regulation of protein glycosylation (GO:0060049)2.21742820
142regulation of protein polyubiquitination (GO:1902914)2.21567652
143pyrimidine ribonucleoside catabolic process (GO:0046133)2.21497345
144protein targeting to Golgi (GO:0000042)2.21402211
145positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.21238617
146forelimb morphogenesis (GO:0035136)2.21039891
147dermatan sulfate metabolic process (GO:0030205)2.19531903
148positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.19181973
149positive regulation of meiosis (GO:0045836)2.19052863
150extracellular regulation of signal transduction (GO:1900115)2.18949210
151extracellular negative regulation of signal transduction (GO:1900116)2.18949210
152regulation of phospholipase A2 activity (GO:0032429)2.18733314
153positive regulation of transforming growth factor beta production (GO:0071636)2.17403500
154ovulation from ovarian follicle (GO:0001542)2.16691102
155keratinocyte development (GO:0003334)2.15985610
156regulation of heterotypic cell-cell adhesion (GO:0034114)2.14902341
157cilium morphogenesis (GO:0060271)2.14822985
158metanephric mesenchyme development (GO:0072075)2.14392776
159positive regulation of interleukin-1 beta secretion (GO:0050718)2.14365696
160regulation of fibrinolysis (GO:0051917)2.14000790
161protein heterotrimerization (GO:0070208)2.12580254
162negative regulation of complement activation (GO:0045916)2.12263122
163gland morphogenesis (GO:0022612)2.12254120
164negative chemotaxis (GO:0050919)2.12180378
165negative regulation of protein autophosphorylation (GO:0031953)2.12114227
166regulation of keratinocyte proliferation (GO:0010837)2.11553367
167retrograde transport, vesicle recycling within Golgi (GO:0000301)2.11279223
168negative regulation of signal transduction by p53 class mediator (GO:1901797)2.11259880
169positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.10909662
170membrane raft organization (GO:0031579)2.10733941
171regulation of protein activation cascade (GO:2000257)2.10213791
172establishment of apical/basal cell polarity (GO:0035089)2.10114371
173dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.09656258
174positive regulation of meiotic cell cycle (GO:0051446)2.09130572
175positive regulation of cardiac muscle cell differentiation (GO:2000727)2.08854692
176morphogenesis of an epithelial fold (GO:0060571)2.08646705
177regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.08080548
178glycosphingolipid biosynthetic process (GO:0006688)2.07404351
179bone remodeling (GO:0046849)2.07327132
180kidney mesenchyme development (GO:0072074)2.07286748
181regulation of complement activation (GO:0030449)2.06775202
182anterograde synaptic vesicle transport (GO:0048490)2.06714644
183regulation of chemokine-mediated signaling pathway (GO:0070099)2.06591242
184middle ear morphogenesis (GO:0042474)2.06513015
185fibrinolysis (GO:0042730)2.06230291
186pathway-restricted SMAD protein phosphorylation (GO:0060389)2.04930958
187apoptotic process involved in morphogenesis (GO:0060561)2.04521255
188positive regulation of hemostasis (GO:1900048)2.04506529
189positive regulation of blood coagulation (GO:0030194)2.04506529

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.86972825
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.87807583
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.49979733
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.49979733
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.49979733
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.30785815
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.88291151
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.87939118
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.75167318
10* TRIM28_21343339_ChIP-Seq_HEK293_Human2.74514763
11* GBX2_23144817_ChIP-Seq_PC3_Human2.73304570
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.73186634
13* SALL1_21062744_ChIP-ChIP_HESCs_Human2.72547525
14* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.71203479
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.48279181
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.47729343
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.32139452
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.25896764
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25875240
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25485960
21ESR1_21235772_ChIP-Seq_MCF-7_Human2.22250056
22ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.18134253
23* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.18080096
24PIAS1_25552417_ChIP-Seq_VCAP_Human2.16934172
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.13927467
26* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.09309226
27CJUN_26792858_Chip-Seq_BT549_Human2.06645508
28RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06064934
29HIF1A_21447827_ChIP-Seq_MCF-7_Human2.05484881
30FLI1_27457419_Chip-Seq_LIVER_Mouse2.04149639
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.01151235
32CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.00157278
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.94713747
34* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.91128709
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.89793398
36* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.87803093
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.87512538
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84733654
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.82400252
40* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.82261963
41* BRD4_25478319_ChIP-Seq_HGPS_Human1.81588628
42SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.80794346
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.80794346
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80551669
45SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.80250340
46VDR_22108803_ChIP-Seq_LS180_Human1.77728857
47* TP53_18474530_ChIP-ChIP_U2OS_Human1.77252331
48SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.76175373
49* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.74889165
50NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.74553766
51ZNF274_21170338_ChIP-Seq_K562_Hela1.74033495
52P300_19829295_ChIP-Seq_ESCs_Human1.73749392
53* SMAD4_21799915_ChIP-Seq_A2780_Human1.72359869
54* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.72141635
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.71849510
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.71570609
57ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.71499910
58CLOCK_20551151_ChIP-Seq_293T_Human1.71066201
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70261138
60* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.69295045
61* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.68212852
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67326604
63* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66864430
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.66099526
65* EZH2_27294783_Chip-Seq_NPCs_Mouse1.65587448
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.64678717
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64531144
68* LXR_22158963_ChIP-Seq_LIVER_Mouse1.62470967
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61826203
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59034617
71* FUS_26573619_Chip-Seq_HEK293_Human1.57483918
72* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.57357404
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57252543
74PPARA_22158963_ChIP-Seq_LIVER_Mouse1.55072721
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54985251
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.53835609
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53171707
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.50321510
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.50174237
80FOXM1_23109430_ChIP-Seq_U2OS_Human1.49302503
81* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45803811
82BCAT_22108803_ChIP-Seq_LS180_Human1.45070737
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44754414
84ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.44409899
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42947414
86* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.42656435
87* STAT3_23295773_ChIP-Seq_U87_Human1.42342078
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.39503376
89TP53_16413492_ChIP-PET_HCT116_Human1.38396755
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37844130
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37844130
92ER_23166858_ChIP-Seq_MCF-7_Human1.35627311
93* EWS_26573619_Chip-Seq_HEK293_Human1.35529728
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.34962832
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34502739
96STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34001335
97* CRX_20693478_ChIP-Seq_RETINA_Mouse1.33870282
98AR_25329375_ChIP-Seq_VCAP_Human1.33504586
99* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33422242
100* IRF8_22096565_ChIP-ChIP_GC-B_Human1.32648091
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32327244
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31301372
103IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30870527
104CBP_20019798_ChIP-Seq_JUKART_Human1.30870527
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29125478
106TAF15_26573619_Chip-Seq_HEK293_Human1.28204153
107PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27730766
108SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27655990
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27492988
110* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.26160821
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.23179291
112* CDX2_22108803_ChIP-Seq_LS180_Human1.22908612
113RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22239671
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22048085
115GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21880659
116P53_22387025_ChIP-Seq_ESCs_Mouse1.21567583
117* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17405189
118GATA2_21666600_ChIP-Seq_HMVEC_Human1.15720520
119* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.15219606
120* TCF4_23295773_ChIP-Seq_U87_Human1.15020181
121CDX2_20551321_ChIP-Seq_CACO-2_Human1.13921707
122* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13807523
123* FLI1_21867929_ChIP-Seq_TH2_Mouse1.12949572
124* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11763427
125HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11744940
126CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11141615
127E2F1_18555785_Chip-Seq_ESCs_Mouse1.11091304
128TCF4_22108803_ChIP-Seq_LS180_Human1.10436678
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09777467
130JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09031424
131MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08368339
132CMYC_18555785_Chip-Seq_ESCs_Mouse1.07149983
133* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06525776
134ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04510284
135IGF1R_20145208_ChIP-Seq_DFB_Human1.04224926
136STAT3_18555785_Chip-Seq_ESCs_Mouse1.02816762
137* PRDM14_20953172_ChIP-Seq_ESCs_Human1.02303524
138KDM2B_26808549_Chip-Seq_REH_Human1.02167352
139* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02124407
140* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02018145
141NANOG_19829295_ChIP-Seq_ESCs_Human1.01711333
142SOX2_19829295_ChIP-Seq_ESCs_Human1.01711333
143* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.01669246
144* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.01197111
145FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00734088
146* UBF1/2_26484160_Chip-Seq_HMECs_Human1.00549824
147* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00476881
148NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00379601
149SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99768854
150* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99713563
151FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99587779
152* SOX2_20726797_ChIP-Seq_SW620_Human0.99555882
153* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.99387700
154* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99091946
155AR_21572438_ChIP-Seq_LNCaP_Human0.98839743
156* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97975501
157EP300_21415370_ChIP-Seq_HL-1_Mouse0.97738648
158SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97649913
159STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97544451
160ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97415018
161* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97166768
162AHR_22903824_ChIP-Seq_MCF-7_Human0.96742584
163* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96694009
164BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95987080
165* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95028471
166SMAD4_21741376_ChIP-Seq_EPCs_Human0.94919002
167* NANOG_16518401_ChIP-PET_MESCs_Mouse0.94916484
168WT1_19549856_ChIP-ChIP_CCG9911_Human0.93428184
169IRF8_21731497_ChIP-ChIP_J774_Mouse0.93284495
170TCF4_18268006_ChIP-ChIP_LS174T_Human0.92125154
171* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91652205
172* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89711948
173ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89343109
174TP63_23658742_ChIP-Seq_EP156T_Human0.88364493
175* ISL1_27105846_Chip-Seq_CPCs_Mouse0.87394494
176CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87301363
177E2F7_22180533_ChIP-Seq_HELA_Human0.86284721

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.19411533
2MP0003705_abnormal_hypodermis_morpholog3.75860756
3MP0009780_abnormal_chondrocyte_physiolo3.60726010
4MP0005275_abnormal_skin_tensile3.36065646
5MP0000372_irregular_coat_pigmentation2.97150395
6MP0010352_gastrointestinal_tract_polyps2.92062423
7MP0010386_abnormal_urinary_bladder2.80417489
8MP0006054_spinal_hemorrhage2.79786001
9MP0005503_abnormal_tendon_morphology2.65680462
10MP0005171_absent_coat_pigmentation2.51684379
11MP0003941_abnormal_skin_development2.47723012
12MP0003566_abnormal_cell_adhesion2.46833032
13MP0005023_abnormal_wound_healing2.43271252
14MP0003195_calcinosis2.30901559
15MP0002060_abnormal_skin_morphology2.20894093
16MP0002876_abnormal_thyroid_physiology2.18644222
17MP0004272_abnormal_basement_membrane2.14671388
18MP0002102_abnormal_ear_morphology2.11471424
19MP0003279_aneurysm2.05875100
20MP0002254_reproductive_system_inflammat2.02139538
21MP0005076_abnormal_cell_differentiation2.01156671
22MP0000569_abnormal_digit_pigmentation1.90229686
23MP0003453_abnormal_keratinocyte_physiol1.88588660
24* MP0003091_abnormal_cell_migration1.78094186
25MP0009384_cardiac_valve_regurgitation1.77089042
26MP0000013_abnormal_adipose_tissue1.76538190
27MP0005623_abnormal_meninges_morphology1.75938935
28MP0010368_abnormal_lymphatic_system1.69458473
29MP0005174_abnormal_tail_pigmentation1.67446279
30MP0000538_abnormal_urinary_bladder1.61149968
31MP0000015_abnormal_ear_pigmentation1.58846963
32MP0003724_increased_susceptibility_to1.56620188
33MP0002295_abnormal_pulmonary_circulatio1.55847008
34MP0000427_abnormal_hair_cycle1.53038611
35* MP0005508_abnormal_skeleton_morphology1.49180119
36MP0010030_abnormal_orbit_morphology1.47816699
37MP0003045_fibrosis1.44920107
38MP0009053_abnormal_anal_canal1.44663736
39MP0001299_abnormal_eye_distance/1.43910079
40MP0005084_abnormal_gallbladder_morpholo1.43379545
41MP0004134_abnormal_chest_morphology1.38176414
42MP0001958_emphysema1.37633337
43MP0005595_abnormal_vascular_smooth1.35704227
44MP0003828_pulmonary_edema1.32832155
45MP0005248_abnormal_Harderian_gland1.32204910
46* MP0000767_abnormal_smooth_muscle1.31869922
47MP0000733_abnormal_muscle_development1.30797502
48MP0005367_renal/urinary_system_phenotyp1.29896672
49MP0000516_abnormal_urinary_system1.29896672
50MP0003448_altered_tumor_morphology1.29698944
51MP0005257_abnormal_intraocular_pressure1.28052800
52MP0002928_abnormal_bile_duct1.27619668
53MP0001243_abnormal_dermal_layer1.27220624
54MP0003950_abnormal_plasma_membrane1.25084204
55MP0003436_decreased_susceptibility_to1.24476998
56MP0002168_other_aberrant_phenotype1.23206822
57MP0003252_abnormal_bile_duct1.20551587
58MP0002938_white_spotting1.20337717
59MP0005551_abnormal_eye_electrophysiolog1.16746531
60MP0002796_impaired_skin_barrier1.15019465
61MP0000749_muscle_degeneration1.13929515
62* MP0005390_skeleton_phenotype1.10964288
63MP0004883_abnormal_blood_vessel1.10796103
64MP0002282_abnormal_trachea_morphology1.09383507
65MP0002006_tumorigenesis1.07828299
66MP0003385_abnormal_body_wall1.07382450
67MP0001756_abnormal_urination1.06627786
68MP0002249_abnormal_larynx_morphology1.06377572
69MP0000230_abnormal_systemic_arterial1.05723735
70MP0005365_abnormal_bile_salt1.05122739
71MP0002837_dystrophic_cardiac_calcinosis1.04844263
72MP0009278_abnormal_bone_marrow1.04330627
73MP0001216_abnormal_epidermal_layer1.04228647
74MP0002108_abnormal_muscle_morphology1.04059912
75MP0001348_abnormal_lacrimal_gland1.03465019
76MP0004947_skin_inflammation1.03222188
77MP0002166_altered_tumor_susceptibility1.02929412
78MP0005360_urolithiasis1.02326639
79MP0000383_abnormal_hair_follicle1.01134757
80MP0005670_abnormal_white_adipose1.00405186
81MP0005395_other_phenotype1.00127876
82MP0001879_abnormal_lymphatic_vessel0.99989237
83MP0001849_ear_inflammation0.99717855
84MP0006072_abnormal_retinal_apoptosis0.99079732
85MP0003300_gastrointestinal_ulcer0.98515418
86MP0005085_abnormal_gallbladder_physiolo0.98418649
87* MP0003755_abnormal_palate_morphology0.98387201
88MP0000762_abnormal_tongue_morphology0.98364331
89MP0005164_abnormal_response_to0.98271020
90MP0002177_abnormal_outer_ear0.97935804
91MP0001533_abnormal_skeleton_physiology0.96743809
92MP0000534_abnormal_ureter_morphology0.96686522
93MP0010307_abnormal_tumor_latency0.95701765
94MP0002160_abnormal_reproductive_system0.94195397
95MP0002115_abnormal_skeleton_extremities0.93502209
96MP0000371_diluted_coat_color0.92373620
97MP0002925_abnormal_cardiovascular_devel0.90924533
98MP0002086_abnormal_extraembryonic_tissu0.90864987
99MP0000627_abnormal_mammary_gland0.90622631
100MP0005389_reproductive_system_phenotype0.88503332
101MP0000163_abnormal_cartilage_morphology0.88045969
102MP0002638_abnormal_pupillary_reflex0.88021538
103MP0001270_distended_abdomen0.88005076
104MP0005253_abnormal_eye_physiology0.86904669
105* MP0000432_abnormal_head_morphology0.85264766
106MP0003283_abnormal_digestive_organ0.84417898
107MP0001501_abnormal_sleep_pattern0.84094236
108MP0004264_abnormal_extraembryonic_tissu0.83689619
109MP0002163_abnormal_gland_morphology0.83274926
110MP0000566_synostosis0.83068827
111MP0004484_altered_response_of0.82930917
112MP0004142_abnormal_muscle_tone0.82633164
113MP0000858_altered_metastatic_potential0.81741994
114MP0008775_abnormal_heart_ventricle0.81658626
115MP0002697_abnormal_eye_size0.81488339
116MP0005620_abnormal_muscle_contractility0.81362814
117MP0002933_joint_inflammation0.81084085
118MP0002277_abnormal_respiratory_mucosa0.80986975
119MP0009250_abnormal_appendicular_skeleto0.80933649
120MP0001915_intracranial_hemorrhage0.79597117
121MP0009764_decreased_sensitivity_to0.79342169
122MP0005501_abnormal_skin_physiology0.78155774
123MP0000613_abnormal_salivary_gland0.77914104
124MP0002009_preneoplasia0.77573626
125MP0005408_hypopigmentation0.77458215
126MP0001614_abnormal_blood_vessel0.77410012
127MP0001542_abnormal_bone_strength0.77323650
128MP0003935_abnormal_craniofacial_develop0.77062034
129MP0003115_abnormal_respiratory_system0.75610748
130MP0000579_abnormal_nail_morphology0.75567903
131MP0002095_abnormal_skin_pigmentation0.75414774
132MP0003303_peritoneal_inflammation0.74815732
133MP0003890_abnormal_embryonic-extraembry0.74383304
134MP0006082_CNS_inflammation0.74179517
135MP0010678_abnormal_skin_adnexa0.73594337
136MP0002896_abnormal_bone_mineralization0.72932729
137MP0001851_eye_inflammation0.72651893
138MP0002998_abnormal_bone_remodeling0.72436416
139MP0002332_abnormal_exercise_endurance0.71995979
140MP0005646_abnormal_pituitary_gland0.71911184
141MP0002128_abnormal_blood_circulation0.71240617
142MP0005380_embryogenesis_phenotype0.70740401
143MP0001672_abnormal_embryogenesis/_devel0.70740401
144MP0002088_abnormal_embryonic_growth/wei0.70505459
145MP0000467_abnormal_esophagus_morphology0.70432180
146MP0002098_abnormal_vibrissa_morphology0.70357034
147MP0001175_abnormal_lung_morphology0.70239264
148MP0001191_abnormal_skin_condition0.69647575
149MP0002084_abnormal_developmental_patter0.69627191
150MP0003942_abnormal_urinary_system0.69388093
151MP0001984_abnormal_olfaction0.69034491
152MP0003984_embryonic_growth_retardation0.68999374
153* MP0002135_abnormal_kidney_morphology0.67472493
154MP0004381_abnormal_hair_follicle0.66642125
155MP0003937_abnormal_limbs/digits/tail_de0.63063649
156MP0002109_abnormal_limb_morphology0.62736582
157MP0002090_abnormal_vision0.60242375
158MP0004215_abnormal_myocardial_fiber0.59989223
159MP0005379_endocrine/exocrine_gland_phen0.59389190
160MP0000685_abnormal_immune_system0.57943165
161MP0002751_abnormal_autonomic_nervous0.57383296
162MP0005332_abnormal_amino_acid0.57182947
163MP0003011_delayed_dark_adaptation0.56186194
164MP0003936_abnormal_reproductive_system0.55762705
165MP0004885_abnormal_endolymph0.55393467

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.03909365
2Premature rupture of membranes (HP:0001788)4.25202296
3Follicular hyperkeratosis (HP:0007502)4.12121681
4Shallow orbits (HP:0000586)3.59778268
5Peritonitis (HP:0002586)3.51070592
6Keratoconus (HP:0000563)3.43084185
7Increased corneal curvature (HP:0100692)3.43084185
8Albinism (HP:0001022)3.42174092
9Atrophic scars (HP:0001075)3.29113980
10Aortic dissection (HP:0002647)3.16289412
11Aortic aneurysm (HP:0004942)3.12432034
12Myocardial infarction (HP:0001658)3.12118795
13Thyroiditis (HP:0100646)3.07583716
14Mesomelia (HP:0003027)3.04618941
15Ankle contracture (HP:0006466)2.89381025
16Metaphyseal dysplasia (HP:0100255)2.89160164
17Congenital sensorineural hearing impairment (HP:0008527)2.88391298
18Lip pit (HP:0100267)2.82988587
19Cerebral aneurysm (HP:0004944)2.77727949
20Increased connective tissue (HP:0009025)2.73498117
21Delayed gross motor development (HP:0002194)2.71893347
22Hypoplastic ischia (HP:0003175)2.69117056
23Pancreatic cysts (HP:0001737)2.68581380
24Abnormality of midbrain morphology (HP:0002418)2.68322050
25Molar tooth sign on MRI (HP:0002419)2.68322050
26Abnormality of the phalanges of the 2nd finger (HP:0009541)2.66777617
27Hypothermia (HP:0002045)2.65008061
28Alopecia of scalp (HP:0002293)2.61508903
29Cutaneous melanoma (HP:0012056)2.60440642
30Right ventricular cardiomyopathy (HP:0011663)2.58965765
31Medial flaring of the eyebrow (HP:0010747)2.57839622
32Dilatation of the ascending aorta (HP:0005111)2.54698584
33Pancreatic fibrosis (HP:0100732)2.49562280
34Abnormality of the nasal septum (HP:0000419)2.48972932
35Vascular tortuosity (HP:0004948)2.47084283
36Mitral valve prolapse (HP:0001634)2.45232005
37Camptodactyly of toe (HP:0001836)2.39946647
38Abnormality of the ischium (HP:0003174)2.39686243
39Prostate neoplasm (HP:0100787)2.35764332
40Broad metatarsal (HP:0001783)2.35534915
41Soft skin (HP:0000977)2.35296804
42Hamartoma of the eye (HP:0010568)2.35022154
43Vertebral compression fractures (HP:0002953)2.30306256
44Hypoplasia of the iris (HP:0007676)2.29590223
45Autoimmune hemolytic anemia (HP:0001890)2.29122723
46True hermaphroditism (HP:0010459)2.27998800
47Genu recurvatum (HP:0002816)2.26244499
48Wrist flexion contracture (HP:0001239)2.25827832
49Fused cervical vertebrae (HP:0002949)2.23635856
50Aneurysm (HP:0002617)2.22992596
51Congenital stationary night blindness (HP:0007642)2.21706890
52Blue sclerae (HP:0000592)2.17908720
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.16954522
54Absent phalangeal crease (HP:0006109)2.16744824
55Urethral obstruction (HP:0000796)2.16548754
56Hypoplasia of the odontoid process (HP:0003311)2.16262172
57Distal lower limb amyotrophy (HP:0008944)2.15195084
58Abnormality of the renal cortex (HP:0011035)2.14749667
59Chronic hepatic failure (HP:0100626)2.12251820
60Striae distensae (HP:0001065)2.11837342
61Spondylolisthesis (HP:0003302)2.11383037
62Oligodontia (HP:0000677)2.11217034
63Bell-shaped thorax (HP:0001591)2.10884443
64Fragile skin (HP:0001030)2.10687201
65Osteolytic defects of the phalanges of the hand (HP:0009771)2.08876015
66Osteolytic defects of the hand bones (HP:0009699)2.08876015
67Arterial tortuosity (HP:0005116)2.08131807
68Abnormality of proline metabolism (HP:0010907)2.07197246
69Hydroxyprolinuria (HP:0003080)2.07197246
70Abnormal finger flexion creases (HP:0006143)2.06883041
71Cervical subluxation (HP:0003308)2.05976938
72Bulbous nose (HP:0000414)2.02855626
73Wormian bones (HP:0002645)2.02227288
74Hypochromic microcytic anemia (HP:0004840)2.01546636
75Hypoplastic iliac wings (HP:0002866)2.00948081
76Aplasia of the musculature (HP:0100854)2.00817561
77Abnormality of the wing of the ilium (HP:0011867)2.00455685
78Shawl scrotum (HP:0000049)2.00106738
79Joint contractures involving the joints of the feet (HP:0100492)1.97972594
80Flexion contracture of toe (HP:0005830)1.97972594
81Disproportionate short-trunk short stature (HP:0003521)1.97170447
82Gaze-evoked nystagmus (HP:0000640)1.97053375
83Tubular atrophy (HP:0000092)1.96991142
84Congenital primary aphakia (HP:0007707)1.96355419
85Genetic anticipation (HP:0003743)1.95998771
86Hypoalbuminemia (HP:0003073)1.94578235
87Abnormal albumin level (HP:0012116)1.94578235
88Intrahepatic cholestasis (HP:0001406)1.93404756
89Abnormal hemoglobin (HP:0011902)1.93060498
90Corneal dystrophy (HP:0001131)1.92981960
91Cortical dysplasia (HP:0002539)1.92833037
92Patchy hypopigmentation of hair (HP:0011365)1.91973453
93Increased number of teeth (HP:0011069)1.91414464
94Spinal cord lesions (HP:0100561)1.91245526
95Syringomyelia (HP:0003396)1.91245526
96Nephronophthisis (HP:0000090)1.91104163
97Aortic regurgitation (HP:0001659)1.90692460
98Coronal craniosynostosis (HP:0004440)1.89554378
99Hyperventilation (HP:0002883)1.88962120
100Gait imbalance (HP:0002141)1.88956504
101Aplasia/Hypoplasia of the tibia (HP:0005772)1.88662532
102Hypoproteinemia (HP:0003075)1.88239618
103Distal lower limb muscle weakness (HP:0009053)1.87936198
104Neonatal short-limb short stature (HP:0008921)1.86407964
105Large for gestational age (HP:0001520)1.86114863
106Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.85112974
107Short 1st metacarpal (HP:0010034)1.85112974
108Abnormality of the renal medulla (HP:0100957)1.84444407
109Abnormal delivery (HP:0001787)1.84369365
110Abnormality of T cell number (HP:0011839)1.83980839
111Ulnar bowing (HP:0003031)1.83679718
112Abnormality of the costochondral junction (HP:0000919)1.83544051
113Narrow palate (HP:0000189)1.83260086
114Febrile seizures (HP:0002373)1.83227924
115Aplasia/Hypoplasia of the lens (HP:0008063)1.83010013
116Spinal rigidity (HP:0003306)1.80467486
117Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.80213447
118Deep venous thrombosis (HP:0002625)1.79936440
119Chorioretinal atrophy (HP:0000533)1.78308641
120Abnormality of the frontal sinuses (HP:0002687)1.77756837
121Esophageal varix (HP:0002040)1.77536598
122Aplasia/Hypoplasia of the fovea (HP:0008060)1.76676825
123Hypoplasia of the fovea (HP:0007750)1.76676825
124Abnormality of the 2nd finger (HP:0004100)1.75633777
125White forelock (HP:0002211)1.75426841
126Abnormal delayed hypersensitivity skin test (HP:0002963)1.75354841
127Genital tract atresia (HP:0001827)1.75165174
128Biconcave vertebral bodies (HP:0004586)1.75052848
129Hyperextensible skin (HP:0000974)1.74880745
130Wide anterior fontanel (HP:0000260)1.74805430
131Short tibia (HP:0005736)1.74282280
132Hypoplastic labia majora (HP:0000059)1.73232294
133Short foot (HP:0001773)1.73015315
134Orchitis (HP:0100796)1.72294304
135Abnormality of the odontoid process (HP:0003310)1.69321140
136Abnormality of the axillary hair (HP:0100134)1.68671383
137Abnormality of secondary sexual hair (HP:0009888)1.68671383
138Cardiovascular calcification (HP:0011915)1.68067423
139Abnormality of the peritoneum (HP:0002585)1.67922910
140Bifid tongue (HP:0010297)1.67353534
141Abnormality of monocarboxylic acid metabolism (HP:0010996)1.67171097
142Periodontitis (HP:0000704)1.66929783
143Abnormality of the labia minora (HP:0012880)1.66853093
144Nephrogenic diabetes insipidus (HP:0009806)1.66617821
145Rib fusion (HP:0000902)1.65947043
146Short nail (HP:0001799)1.65923108
147Flared iliac wings (HP:0002869)1.65912315
148Pulmonary infiltrates (HP:0002113)1.65561314
149Bladder diverticulum (HP:0000015)1.65521030
150Portal hypertension (HP:0001409)1.65488145
151Chromsome breakage (HP:0040012)1.64964437
152Type II lissencephaly (HP:0007260)1.64733367
153Thick nail (HP:0001805)1.64727759
154Abnormality of the hepatic vasculature (HP:0006707)1.64292742
155Hypoalphalipoproteinemia (HP:0003233)1.64138993
156Vaginal atresia (HP:0000148)1.64101857
157Morphological abnormality of the middle ear (HP:0008609)1.63754999
158Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.63615207
159Milia (HP:0001056)1.63598285
160Eczematoid dermatitis (HP:0000976)1.62378218
161Pulmonary artery stenosis (HP:0004415)1.62138404
162Recurrent gram-negative bacterial infections (HP:0005420)1.61183131
163Short humerus (HP:0005792)1.58756380
164Ectopia lentis (HP:0001083)1.58234725
165Absent frontal sinuses (HP:0002688)1.57805816
166Abnormality of the labia majora (HP:0012881)1.57780389
167Persistence of primary teeth (HP:0006335)1.57726827
168Autoimmune thrombocytopenia (HP:0001973)1.57027672
169Broad hallux (HP:0010055)1.56539629
170Abnormality of the salivary glands (HP:0010286)1.56451179
171Sparse scalp hair (HP:0002209)1.55997968
172Long eyelashes (HP:0000527)1.55818646
173Deep philtrum (HP:0002002)1.54799446
174Knee flexion contracture (HP:0006380)1.54419981
175Turricephaly (HP:0000262)1.53896765
176Hip contracture (HP:0003273)1.53832114
177Short 4th metacarpal (HP:0010044)1.53082064
178Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.53082064
179Sparse lateral eyebrow (HP:0005338)1.52403564
180Abnormality of complement system (HP:0005339)1.50386260
181Infantile muscular hypotonia (HP:0008947)1.50329620
182Abnormality of the common coagulation pathway (HP:0010990)1.50289588
183Elbow flexion contracture (HP:0002987)1.48379307
184Hematochezia (HP:0002573)1.47348628
185Depressed nasal tip (HP:0000437)1.46983026

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.28115162
2CDK124.04706505
3MYLK3.32856527
4EPHA32.66259328
5EPHA22.58942295
6FGFR42.58435233
7LATS22.52814576
8EIF2AK32.33576197
9ERBB42.22271350
10ADRBK22.16346365
11DDR22.14611743
12RIPK12.13949938
13ERN12.12119400
14LIMK12.01992584
15PDGFRA1.97966705
16NUAK11.94800042
17GRK11.93794827
18PLK21.90395975
19DMPK1.82834964
20STK38L1.78339045
21AKT31.75639182
22MST41.74030639
23GRK71.72842698
24CHUK1.69005994
25MAP3K61.67056547
26BMPR1B1.66594524
27ACVR1B1.66292821
28MAP3K121.64657365
29TRPM71.64307669
30STK101.63746568
31MAP3K141.61279202
32MAP4K21.59140527
33FER1.55124252
34FGFR31.53651112
35TTN1.50550272
36TRIM281.49761765
37MAP3K31.49174576
38MUSK1.49111726
39SIK11.46688828
40STK31.44955900
41TGFBR21.39307997
42TNIK1.35367860
43STK391.35279309
44BMX1.33574387
45SIK31.32995227
46FGFR21.31592484
47MTOR1.29875069
48TYRO31.25363717
49PTK21.20109116
50MAPKAPK31.19585801
51ADRBK11.19023286
52PRKCE1.18509220
53IKBKB1.17570590
54MAPK131.10906158
55RPS6KA41.09855260
56PIK3CA1.09527970
57CASK1.08631102
58CSK1.06479832
59BRD41.05734853
60PRKD31.04197040
61JAK11.04145388
62PDGFRB1.01843956
63RPS6KB21.01668794
64MOS1.01460931
65PINK10.99669701
66MET0.99647445
67PRKD20.97221903
68PTK2B0.95058103
69TTK0.94843115
70CDK60.94814836
71PIM10.94570826
72FRK0.93800271
73IKBKE0.92651393
74PDK20.92494069
75BMPR20.91629393
76WNK30.91060867
77MAPK150.88272957
78CAMK1D0.87080944
79NLK0.85406028
80FGFR10.82645926
81MAP3K100.82465889
82ZAK0.81485290
83TYK20.81116082
84GRK50.80368878
85INSRR0.78393204
86NEK90.77915400
87EPHB20.77464127
88ABL10.75449175
89PAK20.75388160
90EEF2K0.75068301
91CDK80.74882586
92PIM20.74034504
93WNK40.72401968
94SGK20.71621013
95BCR0.70787583
96MELK0.70730489
97TBK10.70467037
98CDK70.70464133
99MST1R0.70410761
100EPHB10.69365101
101OXSR10.65667670
102JAK30.65209213
103CHEK20.65083758
104EIF2AK20.64811978
105KIT0.63061445
106MAP3K50.61625418
107MAPK10.60943071
108PAK60.59430718
109INSR0.57248981
110EGFR0.57152316
111ERBB20.54111793
112EIF2AK10.53721805
113CAMKK20.53150285
114PRKD10.52872924
115MAPK70.52768240
116OBSCN0.52419881
117MAP2K10.52069145
118ABL20.51300338
119CDK90.50308793
120GSK3A0.50258338
121IRAK30.50099561
122CAMK40.48399231
123CAMK2D0.47330661
124BRSK20.45857084
125CAMK2A0.45818614
126TEC0.44764396
127PBK0.44584898
128SGK30.44468158
129TXK0.43837150
130HCK0.43255743
131PRKAA20.42141548
132ATM0.41934559
133ITK0.41909646
134ERBB30.41362912
135AURKB0.41291516
136PAK30.39822489
137STK380.37106813
138TAOK30.37081393
139STK40.37065143
140PTK60.36487429
141PIK3CG0.36423681
142IGF1R0.36147798
143MARK20.35545429
144IRAK10.35420876
145CSNK1G10.34852480
146TGFBR10.34648390
147CDK40.34422307
148ROCK10.34210915
149PRKCQ0.33971637
150PRKG10.33860897
151PRKCI0.33289740
152CAMK10.32175264
153MARK10.32084891
154PRKCH0.31690582
155HIPK20.31214895
156MAPKAPK50.31078757
157PKN10.29853378

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.76579348
2Adherens junction_Homo sapiens_hsa045202.47010780
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.40290231
4Complement and coagulation cascades_Homo sapiens_hsa046102.19996162
5Circadian rhythm_Homo sapiens_hsa047102.13853627
6Staphylococcus aureus infection_Homo sapiens_hsa051502.12360228
7TGF-beta signaling pathway_Homo sapiens_hsa043502.10005381
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.09850424
9Malaria_Homo sapiens_hsa051442.01457548
10ECM-receptor interaction_Homo sapiens_hsa045122.01362306
11Phototransduction_Homo sapiens_hsa047441.80859444
12MicroRNAs in cancer_Homo sapiens_hsa052061.78407453
13Caffeine metabolism_Homo sapiens_hsa002321.76496774
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70905049
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.67287810
16Amoebiasis_Homo sapiens_hsa051461.62799208
17Lysine degradation_Homo sapiens_hsa003101.61403559
18TNF signaling pathway_Homo sapiens_hsa046681.57067776
19Graft-versus-host disease_Homo sapiens_hsa053321.54883820
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.54649169
21Leishmaniasis_Homo sapiens_hsa051401.54430353
22Sulfur metabolism_Homo sapiens_hsa009201.51156658
23Hippo signaling pathway_Homo sapiens_hsa043901.50393166
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.50027962
25p53 signaling pathway_Homo sapiens_hsa041151.49996537
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.49931400
27Focal adhesion_Homo sapiens_hsa045101.48156460
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48097782
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.45906568
30Proteoglycans in cancer_Homo sapiens_hsa052051.45088338
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41339861
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39421846
33Small cell lung cancer_Homo sapiens_hsa052221.39393184
34Arginine biosynthesis_Homo sapiens_hsa002201.38599727
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37878557
36Nitrogen metabolism_Homo sapiens_hsa009101.37066209
37Vascular smooth muscle contraction_Homo sapiens_hsa042701.36494145
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36457350
39Chemical carcinogenesis_Homo sapiens_hsa052041.33571502
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29270913
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25776527
42Notch signaling pathway_Homo sapiens_hsa043301.23891379
43Regulation of autophagy_Homo sapiens_hsa041401.23786344
44African trypanosomiasis_Homo sapiens_hsa051431.23038151
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21215168
46Renin secretion_Homo sapiens_hsa049241.20504445
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19738772
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19261859
49Linoleic acid metabolism_Homo sapiens_hsa005911.15677055
50Insulin secretion_Homo sapiens_hsa049111.12856113
51Basal cell carcinoma_Homo sapiens_hsa052171.12133520
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10939392
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09880109
54Butanoate metabolism_Homo sapiens_hsa006501.08804138
55Basal transcription factors_Homo sapiens_hsa030221.08274972
56Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07553863
57Calcium signaling pathway_Homo sapiens_hsa040201.05264414
58Influenza A_Homo sapiens_hsa051641.05143313
59Bladder cancer_Homo sapiens_hsa052191.04590372
60Shigellosis_Homo sapiens_hsa051311.04452328
61One carbon pool by folate_Homo sapiens_hsa006701.04427567
62Viral myocarditis_Homo sapiens_hsa054161.04297627
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03545323
64Toxoplasmosis_Homo sapiens_hsa051451.01066288
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00820227
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98310210
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98196229
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98011322
69Propanoate metabolism_Homo sapiens_hsa006400.97904089
70Tryptophan metabolism_Homo sapiens_hsa003800.97338402
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97303624
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96109244
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96049928
74Herpes simplex infection_Homo sapiens_hsa051680.94756818
75Legionellosis_Homo sapiens_hsa051340.94348023
76Mineral absorption_Homo sapiens_hsa049780.93708687
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93641835
78Osteoclast differentiation_Homo sapiens_hsa043800.93404484
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.93339654
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.93227155
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92667255
82Protein digestion and absorption_Homo sapiens_hsa049740.89619315
83Allograft rejection_Homo sapiens_hsa053300.88999270
84Measles_Homo sapiens_hsa051620.87027782
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85461759
86Salmonella infection_Homo sapiens_hsa051320.84909975
87Pathways in cancer_Homo sapiens_hsa052000.84665464
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.84454973
89Pertussis_Homo sapiens_hsa051330.83909969
90Hepatitis B_Homo sapiens_hsa051610.83618854
91Pancreatic cancer_Homo sapiens_hsa052120.82544967
92Sphingolipid metabolism_Homo sapiens_hsa006000.82317565
93HTLV-I infection_Homo sapiens_hsa051660.82308825
94Prostate cancer_Homo sapiens_hsa052150.81043351
95Type I diabetes mellitus_Homo sapiens_hsa049400.78950462
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77966611
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77960652
98Primary immunodeficiency_Homo sapiens_hsa053400.77814633
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.77375206
100Amphetamine addiction_Homo sapiens_hsa050310.77319268
101Ovarian steroidogenesis_Homo sapiens_hsa049130.77003313
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76885390
103Chronic myeloid leukemia_Homo sapiens_hsa052200.76762282
104cAMP signaling pathway_Homo sapiens_hsa040240.76746709
105Cocaine addiction_Homo sapiens_hsa050300.76097788
106Histidine metabolism_Homo sapiens_hsa003400.74392087
107Hematopoietic cell lineage_Homo sapiens_hsa046400.72710141
108Collecting duct acid secretion_Homo sapiens_hsa049660.72262777
109Retinol metabolism_Homo sapiens_hsa008300.71300016
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71126933
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70848883
112Hepatitis C_Homo sapiens_hsa051600.69730328
113Apoptosis_Homo sapiens_hsa042100.69573761
114Morphine addiction_Homo sapiens_hsa050320.69473175
115Selenocompound metabolism_Homo sapiens_hsa004500.68969789
116Salivary secretion_Homo sapiens_hsa049700.68287893
117Dorso-ventral axis formation_Homo sapiens_hsa043200.68147700
118Serotonergic synapse_Homo sapiens_hsa047260.68091770
119Ether lipid metabolism_Homo sapiens_hsa005650.67654940
120Glutamatergic synapse_Homo sapiens_hsa047240.67637707
121Ras signaling pathway_Homo sapiens_hsa040140.65049264
122Tuberculosis_Homo sapiens_hsa051520.64870975
123FoxO signaling pathway_Homo sapiens_hsa040680.62671178
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62610902
125Melanoma_Homo sapiens_hsa052180.61571882
126Circadian entrainment_Homo sapiens_hsa047130.61339857
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.60603175
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60442624
129Rap1 signaling pathway_Homo sapiens_hsa040150.59970744
130Rheumatoid arthritis_Homo sapiens_hsa053230.59962912
131Taste transduction_Homo sapiens_hsa047420.59961442
132Oxytocin signaling pathway_Homo sapiens_hsa049210.59923402
133Dilated cardiomyopathy_Homo sapiens_hsa054140.59807355
134GABAergic synapse_Homo sapiens_hsa047270.59619369
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59597548
136MAPK signaling pathway_Homo sapiens_hsa040100.59458081
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58061901
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57681655
139Prion diseases_Homo sapiens_hsa050200.57047623
140Insulin resistance_Homo sapiens_hsa049310.56911335
141ABC transporters_Homo sapiens_hsa020100.56627168
142Hedgehog signaling pathway_Homo sapiens_hsa043400.55970523
143Autoimmune thyroid disease_Homo sapiens_hsa053200.55885153
144Dopaminergic synapse_Homo sapiens_hsa047280.55516872
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55097900
146T cell receptor signaling pathway_Homo sapiens_hsa046600.54808850
147Cyanoamino acid metabolism_Homo sapiens_hsa004600.54646640
148Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54041924
149Intestinal immune network for IgA production_Homo sapiens_hsa046720.51804916
150Viral carcinogenesis_Homo sapiens_hsa052030.51038429
151Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48892626
152Cell cycle_Homo sapiens_hsa041100.48803381
153Acute myeloid leukemia_Homo sapiens_hsa052210.46813530
154Phenylalanine metabolism_Homo sapiens_hsa003600.45964111
155mTOR signaling pathway_Homo sapiens_hsa041500.44732206
156HIF-1 signaling pathway_Homo sapiens_hsa040660.44538507
157Wnt signaling pathway_Homo sapiens_hsa043100.44388799
158PPAR signaling pathway_Homo sapiens_hsa033200.42994126
159Tight junction_Homo sapiens_hsa045300.42931481

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